metformin has been researched along with Cachexia in 7 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Cachexia: General ill health, malnutrition, and weight loss, usually associated with chronic disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin treatment not only decreases the tumour growth but also improves the protein metabolism in gastrocnemius muscle in tumour-bearing rats." | 5.43 | Metformin treatment modulates the tumour-induced wasting effects in muscle protein metabolism minimising the cachexia in tumour-bearing rats. ( Gomes-Marcondes, MC; Oliveira, AG, 2016) |
| " Metformin emerges as a choice candidate as it acts both on reducing gluconeogenesis and improving insulin sensitivity, and has demonstrated tumour suppressor properties in multiple cancer types." | 4.90 | Cancer cachexia and diabetes: similarities in metabolic alterations and possible treatment. ( Chevalier, S; Farsijani, S, 2014) |
| "Metformin treatment not only decreases the tumour growth but also improves the protein metabolism in gastrocnemius muscle in tumour-bearing rats." | 1.43 | Metformin treatment modulates the tumour-induced wasting effects in muscle protein metabolism minimising the cachexia in tumour-bearing rats. ( Gomes-Marcondes, MC; Oliveira, AG, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (71.43) | 24.3611 |
| 2020's | 2 (28.57) | 2.80 |
| Authors | Studies |
|---|---|
| Bora, VR | 1 |
| Gohel, D | 1 |
| Singh, R | 1 |
| Patel, BM | 1 |
| Knuth, CM | 1 |
| Auger, C | 1 |
| Jeschke, MG | 1 |
| de Fatima Silva, F | 1 |
| Ortiz-Silva, M | 1 |
| Galia, WBS | 1 |
| Cassolla, P | 1 |
| da Silva, FG | 1 |
| Graciano, MFR | 1 |
| Carpinelli, AR | 1 |
| de Souza, HM | 1 |
| Hall, DT | 1 |
| Griss, T | 1 |
| Ma, JF | 1 |
| Sanchez, BJ | 1 |
| Sadek, J | 1 |
| Tremblay, AMK | 1 |
| Mubaid, S | 1 |
| Omer, A | 1 |
| Ford, RJ | 1 |
| Bedard, N | 1 |
| Pause, A | 1 |
| Wing, SS | 1 |
| Di Marco, S | 1 |
| Steinberg, GR | 1 |
| Jones, RG | 1 |
| Gallouzi, IE | 1 |
| Chevalier, S | 1 |
| Farsijani, S | 1 |
| Oliveira, AG | 1 |
| Gomes-Marcondes, MC | 1 |
| Oleksyszyn, J | 1 |
2 reviews available for metformin and Cachexia
| Article | Year |
|---|---|
Burn-induced hypermetabolism and skeletal muscle dysfunction.
Topics: Burns; Cachexia; Epigenesis, Genetic; Exercise; Human Growth Hormone; Humans; Insulin; Metformin; Mu | 2021 |
Cancer cachexia and diabetes: similarities in metabolic alterations and possible treatment.
Topics: Adipose Tissue; Animals; Cachexia; Diabetes Mellitus, Type 2; Energy Metabolism; Glucose; Humans; Hy | 2014 |
5 other studies available for metformin and Cachexia
| Article | Year |
|---|---|
Evaluation of selected antidiabetics in cardiovascular complications associated with cancer cachexia.
Topics: Cachexia; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin; Neoplasms; Sodium-Gluco | 2023 |
Effects of metformin on insulin resistance and metabolic disorders in tumor-bearing rats with advanced cachexia.
Topics: Animals; Cachexia; Insulin; Insulin Resistance; Male; Metformin; Neoplasms; Proto-Oncogene Proteins | 2018 |
The AMPK agonist 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation-associated cachectic muscle wasting.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinase Kinases; Animals; Cachexia; Cell Line; Enzy | 2018 |
Metformin treatment modulates the tumour-induced wasting effects in muscle protein metabolism minimising the cachexia in tumour-bearing rats.
Topics: Animals; Body Composition; Cachexia; Carcinoma 256, Walker; Cell Line, Tumor; Cell Proliferation; Ge | 2016 |
The complete control of glucose level utilizing the composition of ketogenic diet with the gluconeogenesis inhibitor, the anti-diabetic drug metformin, as a potential anti-cancer therapy.
Topics: Blood Glucose; Cachexia; Diet, Ketogenic; Gluconeogenesis; Humans; Hypoglycemic Agents; Metformin; N | 2011 |