metformin has been researched along with Burns in 19 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Burns: Injuries to tissues caused by contact with heat, steam, chemicals (BURNS, CHEMICAL), electricity (BURNS, ELECTRIC), or the like.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin attenuates hyperglycemia and increases muscle protein synthesis in severely burned patients, thereby indicating a metabolic link between hyperglycemia and muscle loss following severe injury." | 9.11 | Influence of metformin on glucose intolerance and muscle catabolism following severe burn injury. ( Gore, DC; Herndon, DN; Sanford, A; Wolf, SE; Wolfe, RR, 2005) |
| "Metformin was given in a double-blind, placebo-controlled fashion to 10 patients, all with burns > 60% body surface area (age, 36 +/- 4 years; weight, 92 +/- 3 kg; mean +/- SEM)." | 9.10 | Metformin blunts stress-induced hyperglycemia after thermal injury. ( Gore, DC; Herndon, DN; Wolf, SE; Wolfe, RR, 2003) |
| "Inflammation is the first stage of this progression, becoming an appealing target of early therapeutic intervention." | 5.62 | Pharmacological activation of SIRT1 by metformin prevented trauma-induced heterotopic ossification through inhibiting macrophage mediated inflammation. ( Fan, C; He, Y; Li, J; Liu, W; Luo, G; Qian, Y; Sun, Z; Wang, F, 2021) |
| "Severely burned adult patients with burns over 20% total body surface area (TBSA) burn were prospectively randomized in this Phase II clinical trial to either metformin or insulin (standard of care) treatment." | 5.22 | Glucose Control in Severely Burned Patients Using Metformin: An Interim Safety and Efficacy Analysis of a Phase II Randomized Controlled Trial. ( Abdullahi, A; Burnett, M; Jeschke, MG; Rehou, S; Stanojcic, M, 2016) |
| "Metformin attenuates hyperglycemia and increases muscle protein synthesis in severely burned patients, thereby indicating a metabolic link between hyperglycemia and muscle loss following severe injury." | 5.11 | Influence of metformin on glucose intolerance and muscle catabolism following severe burn injury. ( Gore, DC; Herndon, DN; Sanford, A; Wolf, SE; Wolfe, RR, 2005) |
| "Metformin was given in a double-blind, placebo-controlled fashion to 10 patients, all with burns > 60% body surface area (age, 36 +/- 4 years; weight, 92 +/- 3 kg; mean +/- SEM)." | 5.10 | Metformin blunts stress-induced hyperglycemia after thermal injury. ( Gore, DC; Herndon, DN; Wolf, SE; Wolfe, RR, 2003) |
| "Data support the efficacy of testosterone, oxandrolone, human recombinant growth hormone, insulin, metformin, and propranolol in improving skeletal muscle protein net balance in patients with severe burns." | 4.91 | Effects of pharmacological interventions on muscle protein synthesis and breakdown in recovery from burns. ( Børsheim, E; Diaz, EC; Herndon, DN; Porter, C; Sidossis, LS; Suman, OE, 2015) |
| "Hyperglycemia has been associated with an increased risk of morbidity and mortality in critically ill patients." | 2.46 | The role of hyperglycemia in burned patients: evidence-based studies. ( Al-Mousawi, AM; Gauglitz, GG; Herndon, DN; Jeschke, MG; Mecott, GA, 2010) |
| "Inflammation is the first stage of this progression, becoming an appealing target of early therapeutic intervention." | 1.62 | Pharmacological activation of SIRT1 by metformin prevented trauma-induced heterotopic ossification through inhibiting macrophage mediated inflammation. ( Fan, C; He, Y; Li, J; Liu, W; Luo, G; Qian, Y; Sun, Z; Wang, F, 2021) |
| "Metformin treatment significantly attenuated muscle catabolism and preserved muscle CSA at the sham size." | 1.56 | Metformin alleviates muscle wasting post-thermal injury by increasing Pax7-positive muscle progenitor cells. ( Amini-Nik, S; Barnes, B; Datu, A; Jeschke, MG; Yousuf, Y, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.26) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (15.79) | 29.6817 |
| 2010's | 9 (47.37) | 24.3611 |
| 2020's | 6 (31.58) | 2.80 |
| Authors | Studies |
|---|---|
| Miricescu, D | 1 |
| Badoiu, SC | 1 |
| Stanescu-Spinu, II | 1 |
| Totan, AR | 1 |
| Stefani, C | 1 |
| Greabu, M | 1 |
| Shi, L | 1 |
| Jiang, Z | 1 |
| Li, J | 2 |
| Lin, H | 1 |
| Xu, B | 1 |
| Liao, X | 1 |
| Fu, Z | 1 |
| Ao, H | 1 |
| Guo, G | 1 |
| Liu, M | 1 |
| Auger, C | 3 |
| Knuth, CM | 2 |
| Abdullahi, A | 3 |
| Samadi, O | 1 |
| Parousis, A | 2 |
| Jeschke, MG | 8 |
| Gus, EI | 1 |
| Shahrokhi, S | 1 |
| Yousuf, Y | 1 |
| Datu, A | 1 |
| Barnes, B | 1 |
| Amini-Nik, S | 1 |
| Sun, Z | 1 |
| Luo, G | 1 |
| Liu, W | 1 |
| He, Y | 1 |
| Wang, F | 1 |
| Qian, Y | 1 |
| Fan, C | 1 |
| Campbell, JM | 1 |
| Adanichkin, N | 1 |
| Kurmis, R | 1 |
| Munn, Z | 1 |
| Rivas, E | 1 |
| Herndon, DN | 7 |
| Porter, C | 2 |
| Meyer, W | 1 |
| Suman, OE | 2 |
| Sivayoganathan, T | 1 |
| Pang, BW | 1 |
| Diaz, EC | 1 |
| Sidossis, LS | 1 |
| Børsheim, E | 1 |
| Burnett, M | 1 |
| Rehou, S | 1 |
| Stanojcic, M | 1 |
| Mecott, GA | 1 |
| Al-Mousawi, AM | 1 |
| Gauglitz, GG | 1 |
| Ballian, N | 1 |
| Rabiee, A | 1 |
| Andersen, DK | 1 |
| Elahi, D | 1 |
| Gibson, BR | 1 |
| Williams, FN | 1 |
| Branski, LK | 1 |
| Gore, DC | 3 |
| Wolf, SE | 2 |
| Wolfe, RR | 3 |
| Sanford, A | 1 |
| Frayn, KN | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Testosterone Gel to Restore Normal Serum Values of Testosterone During the Acute Phase of Critical Illness in Adult ICU Patients[NCT03678233] | Phase 2 | 30 participants (Anticipated) | Interventional | 2019-06-27 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for metformin and Burns
| Article | Year |
|---|---|
Growth Factors, Reactive Oxygen Species, and Metformin-Promoters of the Wound Healing Process in Burns?
Topics: Animals; Burns; Humans; Intercellular Signaling Peptides and Proteins; Metformin; Reactive Oxygen Sp | 2021 |
Anabolic and anticatabolic agents used in burn care: What is known and what is yet to be learned.
Topics: Anabolic Agents; Burns; Clonidine; Growth Hormone-Releasing Hormone; Hormones; Human Growth Hormone; | 2020 |
Burn-induced hypermetabolism and skeletal muscle dysfunction.
Topics: Burns; Cachexia; Epigenesis, Genetic; Exercise; Human Growth Hormone; Humans; Insulin; Metformin; Mu | 2021 |
Intensive insulin therapy, insulin sensitisers and insulin secretagogues for burns: A systematic review of effectiveness and safety.
Topics: Burns; Dipeptidyl-Peptidase IV Inhibitors; Disease Management; Exenatide; Glipizide; Humans; Hypergl | 2018 |
Effects of pharmacological interventions on muscle protein synthesis and breakdown in recovery from burns.
Topics: Adrenergic beta-Antagonists; Anabolic Agents; Androgens; Body Surface Area; Burns; Human Growth Horm | 2015 |
The role of hyperglycemia in burned patients: evidence-based studies.
Topics: Blood Glucose; Burns; Fenofibrate; Humans; Hyperglycemia; Hypoglycemic Agents; Insulin; Metformin | 2010 |
Glucose metabolism in burn patients: the role of insulin and other endocrine hormones.
Topics: Blood Glucose; Burns; Gluconeogenesis; Humans; Hyperglycemia; Hypoglycemic Agents; Insulin; Insulin | 2010 |
What, how, and how much should patients with burns be fed?
Topics: Animals; Blood Glucose; Burns; Catecholamines; Enteral Nutrition; Humans; Hypoglycemic Agents; Insul | 2011 |
4 trials available for metformin and Burns
| Article | Year |
|---|---|
Short-term metformin and exercise training effects on strength, aerobic capacity, glycemic control, and mitochondrial function in children with burn injury.
Topics: Adolescent; Blood Glucose; Burns; Child; Drug Administration Schedule; Energy Metabolism; Exercise; | 2018 |
Glucose Control in Severely Burned Patients Using Metformin: An Interim Safety and Efficacy Analysis of a Phase II Randomized Controlled Trial.
Topics: Blood Glucose; Burns; Fats; Female; Glucose Tolerance Test; Humans; Hypoglycemia; Insulin; Insulin R | 2016 |
Metformin blunts stress-induced hyperglycemia after thermal injury.
Topics: Adult; Blood Glucose; Burns; Diabetes Mellitus; Double-Blind Method; Glucose; Humans; Hyperglycemia; | 2003 |
Influence of metformin on glucose intolerance and muscle catabolism following severe burn injury.
Topics: Adult; Burns; Calorimetry, Indirect; Double-Blind Method; Female; Glucose Intolerance; Humans; Hyper | 2005 |
7 other studies available for metformin and Burns
| Article | Year |
|---|---|
Metformin Improves Burn Wound Healing by Modulating Microenvironmental Fibroblasts and Macrophages.
Topics: Animals; Burns; Collagen; Collagen Type I; Fibroblasts; Lipopolysaccharides; Macrophages; Metformin; | 2022 |
Metformin prevents the pathological browning of subcutaneous white adipose tissue.
Topics: Acetyl-CoA Carboxylase; Adipocytes, Beige; Adipose Tissue, White; Adult; Aminoimidazole Carboxamide; | 2019 |
Metformin alleviates muscle wasting post-thermal injury by increasing Pax7-positive muscle progenitor cells.
Topics: Animals; Burns; Hypoglycemic Agents; Male; Metformin; Mice; Muscle, Skeletal; Muscular Atrophy; PAX7 | 2020 |
Pharmacological activation of SIRT1 by metformin prevented trauma-induced heterotopic ossification through inhibiting macrophage mediated inflammation.
Topics: Animals; Burns; Disease Models, Animal; Humans; Inflammation; Macrophages; Male; Metformin; Mice; Os | 2021 |
Metformin adapts its cellular effects to bioenergetic status in a model of metabolic dysfunction.
Topics: AMP-Activated Protein Kinases; Animals; Burns; Disease Models, Animal; Energy Metabolism; Glucose; H | 2018 |
Comparison of peripheral metabolic effects of insulin and metformin following severe burn injury.
Topics: Adult; Blood Glucose; Burns; Humans; Hypoglycemic Agents; Infusions, Intra-Arterial; Insulin; Metfor | 2005 |
Effects of metformin on insulin resistance after injury in the rat.
Topics: Animals; Blood Glucose; Burns; Glucose; Insulin; Insulin Resistance; Ischemia; Lactates; Liver Glyco | 1976 |