metformin has been researched along with Brain Neoplasms in 42 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
Excerpt | Relevance | Reference |
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"Memantine, mefloquine, and metformin can be combined safely with TMZ in patients with newly diagnosed glioblastoma." | 9.30 | Phase 1 lead-in to a phase 2 factorial study of temozolomide plus memantine, mefloquine, and metformin as postradiation adjuvant therapy for newly diagnosed glioblastoma. ( Aldape, KD; Alfred Yung, WK; Conrad, CA; de Groot, JF; Gilbert, MR; Groves, MD; Hess, KR; Loghin, ME; Mammoser, AG; Maraka, S; Melguizo-Gavilanes, I; O'Brien, BJ; Penas-Prado, M; Puduvalli, VK; Sulman, EP; Tremont-Lukats, IW, 2019) |
"New treatments are needed to improve the overall survival of patients with glioblastoma Metformin is known for anti-tumorigenic effects in cancers, including breast and pancreas cancers." | 8.31 | Metformin use is associated with longer survival in glioblastoma patients with MGMT gene silencing. ( Al-Saadi, T; Diaz, RJ; Jatana, S; Khalaf, R; Mohammad, AH; Ruiz-Barerra, MA, 2023) |
"To investigate the effects of metformin, dichloroacetate (DCA), and memantine on T98G and U87-MG human glioblastoma (GBM) cells to target tumor cell metabolism in a multi-directional manner." | 8.02 | Targeting Cancer Cell Metabolism with Metformin, Dichloroacetate and Memantine in Glioblastoma (GBM). ( Albayrak, G; Dere, UA; Emmez, H; Konac, E, 2021) |
"The purpose of the study is to investigate the efficacy of combined treatment with temozolomide (TMZ) and metformin for glioblastoma (GBM) in vitro and in vivo." | 7.88 | High-Dose Metformin Plus Temozolomide Shows Increased Anti-tumor Effects in Glioblastoma In Vitro and In Vivo Compared with Monotherapy. ( Hong, YK; Lee, JE; Lim, JH; Yang, SH, 2018) |
"It has been reported that metformin acts synergistically with temozolomide (TMZ) to inhibit proliferation of glioma cells including glioblastoma multiforme (GBM)." | 7.83 | Metformin treatment reduces temozolomide resistance of glioblastoma cells. ( Kim, DH; Li, S; Liu, Y; Lu, G; Xue, H; Yang, SH; Zhu, JJ, 2016) |
"High-grade gliomas, glioblastomas (GB), are refractory to conventional treatment combining surgery, chemotherapy, mainly temozolomide, and radiotherapy." | 7.81 | Metformin inhibits growth of human glioblastoma cells and enhances therapeutic response. ( Brem, H; Cohen-Jonathan Moyal, E; Dahan, P; Dang, VT; Lemarié, A; Saland, E; Sarry, JE; Scotland, SJ; Sesen, J; Skuli, N; Toulas, C; Tyler, BM, 2015) |
" Interestingly, our findings showed an association of metformin therapy and prolonged progression-free survival in glioblastoma patients with diabetes and therefore serve as a foundation for further preclinical and clinical investigations." | 7.81 | Metformin influences progression in diabetic glioblastoma patients. ( Adeberg, S; Ben Harrabi, S; Bernhardt, D; Bostel, T; Debus, J; Diehl, C; Koelsche, C; Mohr, A; Rieken, S, 2015) |
"Glioblastoma is the most frequent and lethal primary central nervous system tumor in adults, accounting for around 15% of intracranial neoplasms and 40-50% of all primary malignant brain tumors, with an annual incidence of 3-6 cases per 100,000 population." | 5.72 | Exploring the Mechanism of Adjuvant Treatment of Glioblastoma Using Temozolomide and Metformin. ( Chang, PC; Chen, HY; Feng, SW; Huang, SM; Hueng, DY; Li, YF, 2022) |
"Glioma is the most common type of brain cancer." | 5.62 | Combination of metformin and cold atmospheric plasma induces glioma cell death to associate with c-Fos. ( Ahmad, N; Meng, X; Sun, M; Yang, F; Yang, J; Yu, H; Zhao, R; Zhou, Y; Zhu, C; Zhuang, J, 2021) |
"Metformin has been linked to improve survival of patients with various cancers." | 5.56 | Use of metformin and outcome of patients with newly diagnosed glioblastoma: Pooled analysis. ( Chinot, O; Genbrugge, E; Gorlia, T; Hau, P; Nabors, B; Seliger, C; Stupp, R; Weller, M, 2020) |
"Memantine, mefloquine, and metformin can be combined safely with TMZ in patients with newly diagnosed glioblastoma." | 5.30 | Phase 1 lead-in to a phase 2 factorial study of temozolomide plus memantine, mefloquine, and metformin as postradiation adjuvant therapy for newly diagnosed glioblastoma. ( Aldape, KD; Alfred Yung, WK; Conrad, CA; de Groot, JF; Gilbert, MR; Groves, MD; Hess, KR; Loghin, ME; Mammoser, AG; Maraka, S; Melguizo-Gavilanes, I; O'Brien, BJ; Penas-Prado, M; Puduvalli, VK; Sulman, EP; Tremont-Lukats, IW, 2019) |
"New treatments are needed to improve the overall survival of patients with glioblastoma Metformin is known for anti-tumorigenic effects in cancers, including breast and pancreas cancers." | 4.31 | Metformin use is associated with longer survival in glioblastoma patients with MGMT gene silencing. ( Al-Saadi, T; Diaz, RJ; Jatana, S; Khalaf, R; Mohammad, AH; Ruiz-Barerra, MA, 2023) |
"To investigate the effects of metformin, dichloroacetate (DCA), and memantine on T98G and U87-MG human glioblastoma (GBM) cells to target tumor cell metabolism in a multi-directional manner." | 4.02 | Targeting Cancer Cell Metabolism with Metformin, Dichloroacetate and Memantine in Glioblastoma (GBM). ( Albayrak, G; Dere, UA; Emmez, H; Konac, E, 2021) |
"The purpose of the study is to investigate the efficacy of combined treatment with temozolomide (TMZ) and metformin for glioblastoma (GBM) in vitro and in vivo." | 3.88 | High-Dose Metformin Plus Temozolomide Shows Increased Anti-tumor Effects in Glioblastoma In Vitro and In Vivo Compared with Monotherapy. ( Hong, YK; Lee, JE; Lim, JH; Yang, SH, 2018) |
"It has been reported that metformin acts synergistically with temozolomide (TMZ) to inhibit proliferation of glioma cells including glioblastoma multiforme (GBM)." | 3.83 | Metformin treatment reduces temozolomide resistance of glioblastoma cells. ( Kim, DH; Li, S; Liu, Y; Lu, G; Xue, H; Yang, SH; Zhu, JJ, 2016) |
"High-grade gliomas, glioblastomas (GB), are refractory to conventional treatment combining surgery, chemotherapy, mainly temozolomide, and radiotherapy." | 3.81 | Metformin inhibits growth of human glioblastoma cells and enhances therapeutic response. ( Brem, H; Cohen-Jonathan Moyal, E; Dahan, P; Dang, VT; Lemarié, A; Saland, E; Sarry, JE; Scotland, SJ; Sesen, J; Skuli, N; Toulas, C; Tyler, BM, 2015) |
" Interestingly, our findings showed an association of metformin therapy and prolonged progression-free survival in glioblastoma patients with diabetes and therefore serve as a foundation for further preclinical and clinical investigations." | 3.81 | Metformin influences progression in diabetic glioblastoma patients. ( Adeberg, S; Ben Harrabi, S; Bernhardt, D; Bostel, T; Debus, J; Diehl, C; Koelsche, C; Mohr, A; Rieken, S, 2015) |
"Metformin has in-vitro anti-cancer activity, through AMPK activation and mTOR inhibition." | 3.01 | A Phase I clinical trial of dose-escalated metabolic therapy combined with concomitant radiation therapy in high-grade glioma. ( Amit, U; Anikster, Y; Champ, CE; Cohen, ZR; Furman, O; Genssin, H; Hemi, R; Jan, E; Kanety, H; Lawrence, YR; Mardor, Y; Pechthold, RG; Plotkin, L; Porper, K; Shimoni-Sebag, A; Shpatz, Y; Symon, Z; Talianski, A; Zach, L, 2021) |
"Metformin is an antidiabetic drug currently under investigation as a potential antineoplastic agent." | 1.91 | Heterogeneity of Amino Acid Profiles of Proneural and Mesenchymal Brain-Tumor Initiating Cells. ( Ammer, LM; Dettmer, K; Hau, P; Heckscher, S; Jachnik, B; Leidgens, V; Moeckel, S; Oefner, PJ; Proescholdt, M; Rauer, L; Riemenschneider, MJ; Seliger, C; Vollmann-Zwerenz, A; Wüster, AL, 2023) |
"Glioblastoma is the most frequent and lethal primary central nervous system tumor in adults, accounting for around 15% of intracranial neoplasms and 40-50% of all primary malignant brain tumors, with an annual incidence of 3-6 cases per 100,000 population." | 1.72 | Exploring the Mechanism of Adjuvant Treatment of Glioblastoma Using Temozolomide and Metformin. ( Chang, PC; Chen, HY; Feng, SW; Huang, SM; Hueng, DY; Li, YF, 2022) |
"Glioma is the most common type of brain cancer." | 1.62 | Combination of metformin and cold atmospheric plasma induces glioma cell death to associate with c-Fos. ( Ahmad, N; Meng, X; Sun, M; Yang, F; Yang, J; Yu, H; Zhao, R; Zhou, Y; Zhu, C; Zhuang, J, 2021) |
"Patients with new-onset type 2 diabetes mellitus diagnosed from 1999 to 2005 in the nationwide database of Taiwan's national health insurance were used to enroll study subjects." | 1.62 | Metformin and Risk of Malignant Brain Tumors in Patients with Type 2 Diabetes Mellitus. ( Tseng, CH, 2021) |
"Radiation is a current standard treatment of glioma." | 1.56 | Inhibition of mitochondria NADH-Ubiquinone oxidoreductase (complex I) sensitizes the radioresistant glioma U87MG cells to radiation. ( Dong, H; Feng, B; Gao, C; Gao, X; Mao, W; Sun, C; Wang, J; Wang, Y; Yang, Y; Zhang, B; Zhang, H; Zhang, J; Zhang, L, 2020) |
"Metformin has been linked to improve survival of patients with various cancers." | 1.56 | Use of metformin and outcome of patients with newly diagnosed glioblastoma: Pooled analysis. ( Chinot, O; Genbrugge, E; Gorlia, T; Hau, P; Nabors, B; Seliger, C; Stupp, R; Weller, M, 2020) |
"Treatment with metformin reduced STAT3-phosphorylation in all investigated BTICs and TCs." | 1.46 | Stattic and metformin inhibit brain tumor initiating cells by reducing STAT3-phosphorylation. ( Bogdahn, U; Hau, P; Leidgens, V; Moeckel, S; Proescholdt, M; Proske, J; Rauer, L; Renner, K; Riemenschneider, MJ; Seliger, C; Vollmann-Zwerenz, A, 2017) |
"Metformin treatment may be useful for modulating the metastatic capacity by reducing VEGF expression and blocking epithelial-to-mesenchymal transition." | 1.42 | Clinicopathological significance of N-cadherin and VEGF in advanced gastric cancer brain metastasis and the effects of metformin in preclinical models. ( Chin, HM; Choi, HJ; Jun, KH; Jung, JH; Kim, SH; Kim, YI; Lee, JE; Yang, SH, 2015) |
"Metformin or olanzapine have been shown independently to enhance AMPK activation." | 1.37 | Can the therapeutic effects of temozolomide be potentiated by stimulating AMP-activated protein kinase with olanzepine and metformin? ( Halatsch, ME; Karpel-Massler, G; Kast, RE, 2011) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 24 (57.14) | 24.3611 |
2020's | 18 (42.86) | 2.80 |
Authors | Studies |
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Tseng, CH | 2 |
Sanati, M | 1 |
Aminyavari, S | 1 |
Mollazadeh, H | 1 |
Motamed-Sanaye, A | 1 |
Bibak, B | 1 |
Mohtashami, E | 1 |
Teng, Y | 1 |
Afshari, AR | 1 |
Sahebkar, A | 2 |
Feng, SW | 1 |
Chang, PC | 1 |
Chen, HY | 1 |
Hueng, DY | 1 |
Li, YF | 1 |
Huang, SM | 1 |
Zhu, L | 1 |
Liu, J | 1 |
Qiu, M | 1 |
Chen, J | 2 |
Liang, Q | 1 |
Peng, G | 1 |
Zou, Z | 1 |
Seliger, C | 7 |
Meyer, AL | 1 |
Leidgens, V | 3 |
Rauer, L | 3 |
Moeckel, S | 3 |
Jachnik, B | 3 |
Proske, J | 2 |
Dettmer, K | 3 |
Rothhammer-Hampl, T | 1 |
Kaulen, LD | 1 |
Riemenschneider, MJ | 5 |
Oefner, PJ | 2 |
Kreutz, M | 2 |
Schmidt, NO | 1 |
Merrill, M | 1 |
Uhl, M | 1 |
Renner, K | 3 |
Vollmann-Zwerenz, A | 4 |
Proescholdt, M | 5 |
Hau, P | 7 |
Wüster, AL | 1 |
Ammer, LM | 1 |
Heckscher, S | 1 |
Mohammad, AH | 1 |
Jatana, S | 1 |
Ruiz-Barerra, MA | 1 |
Khalaf, R | 1 |
Al-Saadi, T | 1 |
Diaz, RJ | 1 |
Cole, AJ | 1 |
Fayomi, AP | 1 |
Anyaeche, VI | 1 |
Bai, S | 1 |
Buckanovich, RJ | 1 |
Ayoub, R | 1 |
Ruddy, RM | 1 |
Cox, E | 1 |
Oyefiade, A | 1 |
Derkach, D | 1 |
Laughlin, S | 1 |
Ades-Aron, B | 1 |
Shirzadi, Z | 1 |
Fieremans, E | 1 |
MacIntosh, BJ | 1 |
de Medeiros, CB | 1 |
Skocic, J | 1 |
Bouffet, E | 1 |
Miller, FD | 1 |
Morshead, CM | 1 |
Mabbott, DJ | 1 |
Gibson, EM | 1 |
Monje, M | 1 |
Gao, X | 1 |
Yang, Y | 2 |
Wang, J | 5 |
Zhang, L | 3 |
Sun, C | 1 |
Wang, Y | 3 |
Zhang, J | 4 |
Dong, H | 1 |
Zhang, H | 2 |
Gao, C | 2 |
Zhang, B | 1 |
Feng, B | 1 |
Mao, W | 1 |
Nguépy Keubo, FR | 1 |
Mboua, PC | 1 |
Djifack Tadongfack, T | 1 |
Fokouong Tchoffo, E | 1 |
Tasson Tatang, C | 1 |
Ide Zeuna, J | 1 |
Noupoue, EM | 1 |
Tsoplifack, CB | 1 |
Folefack, GO | 1 |
Kettani, M | 1 |
Bandelier, P | 1 |
Huo, J | 1 |
Li, H | 4 |
Yu, D | 1 |
Arulsamy, N | 1 |
AlAbbad, S | 1 |
Sardot, T | 1 |
Lekashvili, O | 1 |
Decato, D | 1 |
Lelj, F | 1 |
Alexander Ross, JB | 1 |
Rosenberg, E | 1 |
Nazir, H | 1 |
Muthuswamy, N | 1 |
Louis, C | 1 |
Jose, S | 1 |
Prakash, J | 1 |
Buan, MEM | 1 |
Flox, C | 1 |
Chavan, S | 1 |
Shi, X | 1 |
Kauranen, P | 1 |
Kallio, T | 1 |
Maia, G | 1 |
Tammeveski, K | 1 |
Lymperopoulos, N | 1 |
Carcadea, E | 1 |
Veziroglu, E | 1 |
Iranzo, A | 1 |
M Kannan, A | 1 |
Arunamata, A | 1 |
Tacy, TA | 1 |
Kache, S | 1 |
Mainwaring, RD | 1 |
Ma, M | 1 |
Maeda, K | 1 |
Punn, R | 1 |
Noguchi, S | 1 |
Hahn, S | 3 |
Iwasa, Y | 3 |
Ling, J | 2 |
Voccio, JP | 2 |
Kim, Y | 3 |
Song, J | 3 |
Bascuñán, J | 2 |
Chu, Y | 1 |
Tomita, M | 1 |
Cazorla, M | 1 |
Herrera, E | 1 |
Palomeque, E | 1 |
Saud, N | 1 |
Hoplock, LB | 1 |
Lobchuk, MM | 1 |
Lemoine, J | 1 |
Li, X | 10 |
Henson, MA | 1 |
Unsihuay, D | 1 |
Qiu, J | 1 |
Swaroop, S | 1 |
Nagornov, KO | 1 |
Kozhinov, AN | 1 |
Tsybin, YO | 1 |
Kuang, S | 1 |
Laskin, J | 1 |
Zin, NNINM | 1 |
Mohamad, MN | 1 |
Roslan, K | 1 |
Abdul Wafi, S | 1 |
Abdul Moin, NI | 1 |
Alias, A | 1 |
Zakaria, Y | 1 |
Abu-Bakar, N | 1 |
Naveed, A | 1 |
Jilani, K | 1 |
Siddique, AB | 1 |
Akbar, M | 1 |
Riaz, M | 1 |
Mushtaq, Z | 1 |
Sikandar, M | 1 |
Ilyas, S | 1 |
Bibi, I | 1 |
Asghar, A | 1 |
Rasool, G | 1 |
Irfan, M | 1 |
Li, XY | 1 |
Zhao, S | 1 |
Fan, XH | 1 |
Chen, KP | 1 |
Hua, W | 1 |
Liu, ZM | 1 |
Xue, XD | 1 |
Zhou, B | 1 |
Zhang, S | 2 |
Xing, YL | 1 |
Chen, MA | 1 |
Sun, Y | 2 |
Neradilek, MB | 1 |
Wu, XT | 1 |
Zhang, D | 2 |
Huang, W | 1 |
Cui, Y | 1 |
Yang, QQ | 1 |
Li, HW | 1 |
Zhao, XQ | 1 |
Hossein Rashidi, B | 1 |
Tarafdari, A | 1 |
Ghazimirsaeed, ST | 1 |
Shahrokh Tehraninezhad, E | 1 |
Keikha, F | 1 |
Eslami, B | 1 |
Ghazimirsaeed, SM | 1 |
Jafarabadi, M | 1 |
Silvani, Y | 1 |
Lovita, AND | 1 |
Maharani, A | 1 |
Wiyasa, IWA | 1 |
Sujuti, H | 1 |
Ratnawati, R | 1 |
Raras, TYM | 1 |
Lemin, AS | 1 |
Rahman, MM | 1 |
Pangarah, CA | 1 |
Kiyu, A | 1 |
Zeng, C | 2 |
Du, H | 1 |
Lin, D | 1 |
Jalan, D | 1 |
Rubagumya, F | 1 |
Hopman, WM | 1 |
Vanderpuye, V | 1 |
Lopes, G | 1 |
Seruga, B | 1 |
Booth, CM | 1 |
Berry, S | 1 |
Hammad, N | 1 |
Sajo, EA | 1 |
Okunade, KS | 1 |
Olorunfemi, G | 1 |
Rabiu, KA | 1 |
Anorlu, RI | 1 |
Xu, C | 2 |
Xiang, Y | 1 |
Xu, X | 1 |
Zhou, L | 2 |
Dong, X | 1 |
Tang, S | 1 |
Gao, XC | 1 |
Wei, CH | 1 |
Zhang, RG | 1 |
Cai, Q | 1 |
He, Y | 1 |
Tong, F | 1 |
Dong, JH | 1 |
Wu, G | 1 |
Dong, XR | 1 |
Tang, X | 1 |
Tao, F | 1 |
Xiang, W | 1 |
Zhao, Y | 2 |
Jin, L | 1 |
Tao, H | 1 |
Lei, Y | 1 |
Gan, H | 1 |
Huang, Y | 1 |
Chen, Y | 4 |
Chen, L | 3 |
Shan, A | 1 |
Zhao, H | 2 |
Wu, M | 2 |
Ma, Q | 1 |
Zhang, E | 1 |
Li, Y | 6 |
Xue, F | 1 |
Deng, L | 1 |
Liu, L | 2 |
Yan, Z | 2 |
Meng, J | 1 |
Chen, G | 2 |
Anastassiadou, M | 1 |
Bernasconi, G | 1 |
Brancato, A | 1 |
Carrasco Cabrera, L | 1 |
Greco, L | 1 |
Jarrah, S | 1 |
Kazocina, A | 1 |
Leuschner, R | 1 |
Magrans, JO | 1 |
Miron, I | 1 |
Nave, S | 1 |
Pedersen, R | 1 |
Reich, H | 1 |
Rojas, A | 1 |
Sacchi, A | 1 |
Santos, M | 1 |
Theobald, A | 1 |
Vagenende, B | 1 |
Verani, A | 1 |
Du, L | 1 |
Liu, X | 2 |
Ren, Y | 1 |
Li, J | 7 |
Li, P | 1 |
Jiao, Q | 1 |
Meng, P | 1 |
Wang, F | 2 |
Wang, YS | 1 |
Wang, C | 3 |
Zhou, X | 3 |
Wang, W | 1 |
Wang, S | 2 |
Hou, J | 1 |
Zhang, A | 1 |
Lv, B | 1 |
Pang, D | 1 |
Lu, K | 1 |
Ahmad, NH | 1 |
Wang, L | 1 |
Zhu, J | 2 |
Zhuang, T | 1 |
Tu, J | 1 |
Zhao, Z | 1 |
Qu, Y | 1 |
Yao, H | 1 |
Wang, X | 5 |
Lee, DF | 1 |
Shen, J | 3 |
Wen, L | 1 |
Huang, G | 2 |
Xie, X | 1 |
Zhao, Q | 1 |
Hu, W | 1 |
Zhang, Y | 4 |
Wu, X | 1 |
Lu, J | 2 |
Li, M | 1 |
Li, W | 2 |
Wu, W | 1 |
Du, F | 1 |
Ji, H | 1 |
Yang, X | 2 |
Xu, Z | 1 |
Wan, L | 1 |
Wen, Q | 1 |
Cho, CH | 1 |
Zou, C | 1 |
Xiao, Z | 1 |
Liao, J | 1 |
Su, X | 1 |
Bi, Z | 1 |
Su, Q | 1 |
Huang, H | 1 |
Wei, Y | 2 |
Gao, Y | 2 |
Na, KJ | 1 |
Choi, H | 1 |
Oh, HR | 1 |
Kim, YH | 1 |
Lee, SB | 1 |
Jung, YJ | 1 |
Koh, J | 1 |
Park, S | 1 |
Lee, HJ | 1 |
Jeon, YK | 1 |
Chung, DH | 1 |
Paeng, JC | 1 |
Park, IK | 1 |
Kang, CH | 1 |
Cheon, GJ | 1 |
Kang, KW | 1 |
Lee, DS | 1 |
Kim, YT | 1 |
Pajuelo-Lozano, N | 1 |
Alcalá, S | 1 |
Sainz, B | 1 |
Perona, R | 1 |
Sanchez-Perez, I | 1 |
Logotheti, S | 1 |
Marquardt, S | 1 |
Gupta, SK | 1 |
Richter, C | 1 |
Edelhäuser, BAH | 1 |
Engelmann, D | 1 |
Brenmoehl, J | 1 |
Söhnchen, C | 1 |
Murr, N | 1 |
Alpers, M | 1 |
Singh, KP | 1 |
Wolkenhauer, O | 1 |
Heckl, D | 1 |
Spitschak, A | 1 |
Pützer, BM | 1 |
Liao, Y | 1 |
Cheng, J | 1 |
Kong, X | 1 |
Li, S | 2 |
Zhang, M | 4 |
Yang, T | 2 |
Dong, Y | 1 |
Xu, Y | 1 |
Yuan, Z | 1 |
Cao, J | 1 |
Zheng, Y | 1 |
Luo, Z | 1 |
Mei, Z | 1 |
Yao, Y | 1 |
Liu, Z | 2 |
Liang, C | 1 |
Yang, H | 1 |
Song, Y | 1 |
Yu, K | 1 |
Zhu, C | 2 |
Huang, Z | 1 |
Qian, J | 1 |
Ge, J | 1 |
Hu, J | 2 |
Wang, H | 2 |
Liu, Y | 5 |
Mi, Y | 1 |
Kong, H | 1 |
Xi, D | 1 |
Yan, W | 1 |
Luo, X | 1 |
Ning, Q | 1 |
Chang, X | 2 |
Zhang, T | 2 |
Wang, Q | 2 |
Rathore, MG | 1 |
Reddy, K | 1 |
Chen, H | 1 |
Shin, SH | 1 |
Ma, WY | 1 |
Bode, AM | 1 |
Dong, Z | 1 |
Mu, W | 1 |
Liu, C | 3 |
Gao, F | 1 |
Qi, Y | 1 |
Lu, H | 1 |
Zhang, X | 4 |
Cai, X | 1 |
Ji, RY | 1 |
Hou, Y | 3 |
Tian, J | 2 |
Shi, Y | 1 |
Ying, S | 1 |
Tan, M | 1 |
Feng, G | 1 |
Kuang, Y | 1 |
Chen, D | 1 |
Wu, D | 3 |
Zhu, ZQ | 1 |
Tang, HX | 1 |
Shi, ZE | 1 |
Kang, J | 1 |
Liu, Q | 1 |
Qi, J | 2 |
Mu, J | 1 |
Cong, Z | 1 |
Chen, S | 2 |
Fu, D | 1 |
Li, Z | 2 |
Celestrin, CP | 1 |
Rocha, GZ | 1 |
Stein, AM | 1 |
Guadagnini, D | 1 |
Tadelle, RM | 1 |
Saad, MJA | 1 |
Oliveira, AG | 1 |
Bianconi, V | 1 |
Bronzo, P | 1 |
Banach, M | 1 |
Mannarino, MR | 1 |
Pirro, M | 1 |
Patsourakos, NG | 1 |
Kouvari, M | 1 |
Kotidis, A | 1 |
Kalantzi, KI | 1 |
Tsoumani, ME | 1 |
Anastasiadis, F | 1 |
Andronikos, P | 1 |
Aslanidou, T | 1 |
Efraimidis, P | 1 |
Georgiopoulos, A | 1 |
Gerakiou, K | 1 |
Grigoriadou-Skouta, E | 1 |
Grigoropoulos, P | 1 |
Hatzopoulos, D | 1 |
Kartalis, A | 1 |
Lyras, A | 1 |
Markatos, G | 1 |
Mikrogeorgiou, A | 1 |
Myroforou, I | 1 |
Orkopoulos, A | 1 |
Pavlidis, P | 1 |
Petras, C | 1 |
Riga, M | 1 |
Skouloudi, M | 1 |
Smyrnioudis, N | 1 |
Thomaidis, K | 1 |
Tsikouri, GE | 1 |
Tsikouris, EI | 1 |
Zisimos, K | 1 |
Vavoulis, P | 1 |
Vitali, MG | 1 |
Vitsas, G | 1 |
Vogiatzidis, C | 1 |
Chantanis, S | 1 |
Fousas, S | 1 |
Panagiotakos, DB | 1 |
Tselepis, AD | 1 |
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Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Drug Repurposing Using Metformin for Improving the Therapeutic Outcome in Multiple Sclerosis Patients[NCT05298670] | Phase 2 | 80 participants (Anticipated) | Interventional | 2022-02-01 | Recruiting | ||
Placebo Controlled Double Blind Crossover Trial of Metformin for Brain Repair in Children With Cranial-Spinal Radiation for Medulloblastoma[NCT02040376] | Phase 3 | 24 participants (Actual) | Interventional | 2014-06-13 | Completed | ||
Metformin and Neo-adjuvant Temozolomide and Hypofractionated Accelerated Limited-margin Radiotherapy Followed by Adjuvant Temozolomide in Patients With Glioblastoma Multiforme (M-HARTT STUDY)[NCT02780024] | Phase 2 | 50 participants (Anticipated) | Interventional | 2015-03-31 | Active, not recruiting | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
4 reviews available for metformin and Brain Neoplasms
Article | Year |
---|---|
The Potential Therapeutic Impact of Metformin in Glioblastoma Multiforme.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Diabetes Mellitus, Type 2; Glioblast | 2023 |
An evolving paradigm of cancer stem cell hierarchies: therapeutic implications.
Topics: Aldehyde Dehydrogenase 1 Family; Animals; Antigens, CD; Antineoplastic Agents; Biomarkers, Tumor; Br | 2020 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
A Metabolic Inhibitory Cocktail for Grave Cancers: Metformin, Pioglitazone and Lithium Combination in Treatment of Pancreatic Cancer and Glioblastoma Multiforme.
Topics: Brain Neoplasms; Cell Proliferation; Drug Therapy, Combination; Gene Expression Regulation, Neoplast | 2016 |
4 trials available for metformin and Brain Neoplasms
Article | Year |
---|---|
Assessment of cognitive and neural recovery in survivors of pediatric brain tumors in a pilot clinical trial using metformin.
Topics: Adolescent; Adult; Brain; Brain Neoplasms; Cancer Survivors; Child; Child, Preschool; Cognition; Cog | 2020 |
Assessment of cognitive and neural recovery in survivors of pediatric brain tumors in a pilot clinical trial using metformin.
Topics: Adolescent; Adult; Brain; Brain Neoplasms; Cancer Survivors; Child; Child, Preschool; Cognition; Cog | 2020 |
Assessment of cognitive and neural recovery in survivors of pediatric brain tumors in a pilot clinical trial using metformin.
Topics: Adolescent; Adult; Brain; Brain Neoplasms; Cancer Survivors; Child; Child, Preschool; Cognition; Cog | 2020 |
Assessment of cognitive and neural recovery in survivors of pediatric brain tumors in a pilot clinical trial using metformin.
Topics: Adolescent; Adult; Brain; Brain Neoplasms; Cancer Survivors; Child; Child, Preschool; Cognition; Cog | 2020 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
A Phase I clinical trial of dose-escalated metabolic therapy combined with concomitant radiation therapy in high-grade glioma.
Topics: Brain Neoplasms; Combined Modality Therapy; Glioma; Humans; Ketones; Metformin; Middle Aged; Neoplas | 2021 |
Phase 1 lead-in to a phase 2 factorial study of temozolomide plus memantine, mefloquine, and metformin as postradiation adjuvant therapy for newly diagnosed glioblastoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemotherapy, Adjuvant | 2019 |
35 other studies available for metformin and Brain Neoplasms
Article | Year |
---|---|
Metformin Is Associated with a Lower Incidence of Benign Brain Tumors: A Retrospective Cohort Study in Patients with Type 2 Diabetes Mellitus.
Topics: Aged; Brain Neoplasms; Cohort Studies; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agent | 2021 |
Exploring the Mechanism of Adjuvant Treatment of Glioblastoma Using Temozolomide and Metformin.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Diabetes Mellitus, Type 2; DNA | 2022 |
Bacteria-mediated metformin-loaded peptide hydrogel reprograms the tumor immune microenvironment in glioblastoma.
Topics: Bacteria; Brain Neoplasms; Cell Line, Tumor; Glioblastoma; Humans; Hydrogels; Metformin; Peptides; T | 2022 |
Metabolic Heterogeneity of Brain Tumor Cells of Proneural and Mesenchymal Origin.
Topics: Brain; Brain Neoplasms; Cell Line, Tumor; Glioblastoma; Glucose; Humans; Metformin; Neoplastic Stem | 2022 |
Heterogeneity of Amino Acid Profiles of Proneural and Mesenchymal Brain-Tumor Initiating Cells.
Topics: Amino Acids; Brain; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Glioblastoma; Humans; Met | 2023 |
Metformin use is associated with longer survival in glioblastoma patients with MGMT gene silencing.
Topics: Brain Neoplasms; Diabetes Mellitus, Type 2; DNA Methylation; DNA Modification Methylases; DNA Repair | 2023 |
Treating cancer therapy-related cognitive impairment.
Topics: Brain Neoplasms; Child; Cognitive Dysfunction; Female; Humans; Male; Metformin; Neurons; Radiotherap | 2020 |
Inhibition of mitochondria NADH-Ubiquinone oxidoreductase (complex I) sensitizes the radioresistant glioma U87MG cells to radiation.
Topics: Brain Neoplasms; Cell Line, Tumor; Electron Transport Complex I; Enzyme Inhibitors; Glioma; Humans; | 2020 |
Combination of metformin and cold atmospheric plasma induces glioma cell death to associate with c-Fos.
Topics: Apoptosis; Brain Neoplasms; Cell Death; Cell Line, Tumor; Cell Proliferation; Glioma; Humans; Hydrog | 2021 |
Targeting Cancer Cell Metabolism with Metformin, Dichloroacetate and Memantine in Glioblastoma (GBM).
Topics: Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Dichloroacetic A | 2021 |
The protein kinase LKB1 promotes self-renewal and blocks invasiveness in glioblastoma.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation | 2022 |
Metformin and Risk of Malignant Brain Tumors in Patients with Type 2 Diabetes Mellitus.
Topics: Aged; Brain Neoplasms; Cohort Studies; Diabetes Mellitus, Type 2; Female; Humans; Incidence; Male; M | 2021 |
Complex I inhibition augments dichloroacetate cytotoxicity through enhancing oxidative stress in VM-M3 glioblastoma cells.
Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Ce | 2017 |
High-Dose Metformin Plus Temozolomide Shows Increased Anti-tumor Effects in Glioblastoma In Vitro and In Vivo Compared with Monotherapy.
Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neopla | 2018 |
Metformin Treatment Inhibits Motility and Invasion of Glioblastoma Cancer Cells.
Topics: Antineoplastic Agents; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Pro | 2018 |
Use of metformin and survival of patients with high-grade glioma.
Topics: Adult; Aged; Aged, 80 and over; Brain Neoplasms; Disease-Free Survival; Female; Germany; Glioma; Hum | 2019 |
Combined Modulation of Tumor Metabolism by Metformin and Diclofenac in Glioma.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Prol | 2018 |
Searching for the roots of brain cancer.
Topics: Animals; Brain Neoplasms; Cell Phone; Chickenpox; Chickenpox Vaccine; Developed Countries; Diabetes | 2018 |
Influence of metformin, sodium dichloroacetate and their combination on the hematological and biochemical blood parameters of rats with gliomas C6.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Combined Modality Therapy; Dichloroacetic Acid; Female; | 2018 |
Connecting the dots between metformin and high-grade glioma.
Topics: Brain Neoplasms; Glioma; Humans; Metformin | 2019 |
Reply to Lu: Connecting the dots between metformin and high-grade glioma.
Topics: Brain Neoplasms; Glioma; Humans; Metformin | 2019 |
Use of metformin and outcome of patients with newly diagnosed glioblastoma: Pooled analysis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Antineoplastic Combin | 2020 |
Metformin inhibits glioma cell U251 invasion by downregulation of fibulin-3.
Topics: Actins; Blotting, Western; Brain Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Sur | 2013 |
Discrete mechanisms of mTOR and cell cycle regulation by AMPK agonists independent of AMPK.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Brain Neoplasms; Cell Cycle; Cell Proliferation; Cell | 2014 |
Retrospective analysis of the effects of steroid therapy and antidiabetic medication on survival in diabetic glioblastoma patients.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents; Brain Neoplasms; Cohort Studies; | 2013 |
Metformin inhibits growth of human glioblastoma cells and enhances therapeutic response.
Topics: Adenylate Kinase; Animals; Apoptosis; Autophagy; Brain Neoplasms; Cell Division; Cell Line, Tumor; D | 2015 |
Oncometabolic mutation IDH1 R132H confers a metformin-hypersensitive phenotype.
Topics: Brain Neoplasms; Cell Line, Tumor; Humans; Isocitrate Dehydrogenase; Metformin; Mutant Proteins; Mut | 2015 |
Clinicopathological significance of N-cadherin and VEGF in advanced gastric cancer brain metastasis and the effects of metformin in preclinical models.
Topics: Adult; Aged; Aged, 80 and over; Animals; Antigens, CD; Brain Neoplasms; Cadherins; Case-Control Stud | 2015 |
Metformin influences progression in diabetic glioblastoma patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Blood Glucose; Brain; | 2015 |
Metformin and temozolomide act synergistically to inhibit growth of glioma cells and glioma stem cells in vitro and in vivo.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Differentiation; Cell | 2015 |
Inhibition of glioblastoma tumorspheres by combined treatment with 2-deoxyglucose and metformin.
Topics: Animals; Antimetabolites; Apoptosis; Brain Neoplasms; Cell Proliferation; Deoxyglucose; Drug Synergi | 2017 |
Metformin treatment reduces temozolomide resistance of glioblastoma cells.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Line, Tumor; Cell Mov | 2016 |
Stattic and metformin inhibit brain tumor initiating cells by reducing STAT3-phosphorylation.
Topics: Adult; Aged; AMP-Activated Protein Kinases; Animals; Antineoplastic Combined Chemotherapy Protocols; | 2017 |
Can the therapeutic effects of temozolomide be potentiated by stimulating AMP-activated protein kinase with olanzepine and metformin?
Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents, Alkylating; Apoptosis; Benzodiazepine | 2011 |
Glioma-initiating cell elimination by metformin activation of FOXO3 via AMPK.
Topics: AMP-Activated Protein Kinases; Animals; Blood-Brain Barrier; Brain Neoplasms; Cell Differentiation; | 2012 |