metformin has been researched along with Brain Infarction in 2 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Brain Infarction: Tissue NECROSIS in any area of the brain, including the CEREBRAL HEMISPHERES, the CEREBELLUM, and the BRAIN STEM. Brain infarction is the result of a cascade of events initiated by inadequate blood flow through the brain that is followed by HYPOXIA and HYPOGLYCEMIA in brain tissue. Damage may be temporary, permanent, selective or pan-necrosis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin (200 mg/kg) was administrated for up to 14 days." | 1.40 | Metformin attenuates blood-brain barrier disruption in mice following middle cerebral artery occlusion. ( Chen, X; Gu, X; Li, Y; Liu, Y; Tang, G; Wang, Y; Yang, GY; Zhang, Z, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Grissi, M | 1 |
| Boudot, C | 1 |
| Assem, M | 1 |
| Candellier, A | 1 |
| Lando, M | 1 |
| Poirot-Leclercq, S | 1 |
| Boullier, A | 1 |
| Bennis, Y | 1 |
| Lenglet, G | 1 |
| Avondo, C | 1 |
| Lalau, JD | 1 |
| Choukroun, G | 1 |
| Massy, ZA | 1 |
| Kamel, S | 1 |
| Chillon, JM | 1 |
| Hénaut, L | 1 |
| Liu, Y | 1 |
| Tang, G | 1 |
| Li, Y | 1 |
| Wang, Y | 2 |
| Chen, X | 1 |
| Gu, X | 1 |
| Zhang, Z | 1 |
| Yang, GY | 1 |
2 other studies available for metformin and Brain Infarction
| Article | Year |
|---|---|
Metformin prevents stroke damage in non-diabetic female mice with chronic kidney disease.
Topics: Adenylate Kinase; Animals; Apoptosis; Body Weight; Brain Infarction; Enzyme Activation; Female; Gene | 2021 |
Metformin attenuates blood-brain barrier disruption in mice following middle cerebral artery occlusion.
Topics: AMP-Activated Protein Kinases; Animals; Blood-Brain Barrier; Brain Infarction; Cells, Cultured; Cyto | 2014 |