metformin has been researched along with Bone Loss, Osteoclastic in 8 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study explored the mechanism by which metformin (Met) inhibits osteoclast activation and determined its effects on osteoarthritis (OA) mice." | 8.02 | Metformin attenuates osteoclast-mediated abnormal subchondral bone remodeling and alleviates osteoarthritis via AMPK/NF-κB/ERK signaling pathway. ( Ding, D; Guo, H; Jin, Q; Ma, L; Wang, L; Yan, J, 2021) |
| "This study explored the mechanism by which metformin (Met) inhibits osteoclast activation and determined its effects on osteoarthritis (OA) mice." | 4.02 | Metformin attenuates osteoclast-mediated abnormal subchondral bone remodeling and alleviates osteoarthritis via AMPK/NF-κB/ERK signaling pathway. ( Ding, D; Guo, H; Jin, Q; Ma, L; Wang, L; Yan, J, 2021) |
| "Metformin was added to the cultures to evaluate its anti-hypoxic effects." | 1.91 | Metformin Reduces Bone Resorption in Apical Periodontitis Through Regulation of Osteoblast and Osteoclast Differentiation. ( Chen, MH; Cheng, SJ; Hong, CY; Kok, SH; Lai, EH; Lin, HY; Lin, SK; Shun, CT; Wang, HW; Wu, FY; Yang, CN; Yang, H, 2023) |
| "The primary endpoint was changes in bone resorption markers after three months." | 1.46 | The Effects of Pioglitazone on Bone Formation and Resorption Markers in Type 2 Diabetes Mellitus. ( Mori, H; Okada, Y; Tanaka, Y, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 3 (37.50) | 2.80 |
| Authors | Studies |
|---|---|
| Guo, H | 1 |
| Ding, D | 1 |
| Wang, L | 1 |
| Yan, J | 1 |
| Ma, L | 1 |
| Jin, Q | 1 |
| Xie, X | 1 |
| Hu, L | 1 |
| Mi, B | 1 |
| Xue, H | 1 |
| Hu, Y | 1 |
| Panayi, AC | 1 |
| Endo, Y | 1 |
| Chen, L | 1 |
| Yan, C | 1 |
| Lin, Z | 1 |
| Li, H | 1 |
| Zhou, W | 1 |
| Liu, G | 1 |
| Hong, CY | 1 |
| Lin, SK | 1 |
| Wang, HW | 1 |
| Shun, CT | 1 |
| Yang, CN | 1 |
| Lai, EH | 1 |
| Cheng, SJ | 1 |
| Chen, MH | 1 |
| Yang, H | 1 |
| Lin, HY | 1 |
| Wu, FY | 1 |
| Kok, SH | 1 |
| Rozas-Moreno, P | 1 |
| Reyes-García, R | 1 |
| Jódar-Gimeno, E | 1 |
| Varsavsky, M | 1 |
| Luque-Fernández, I | 1 |
| Cortés-Berdonces, M | 1 |
| Muñoz-Torres, M | 1 |
| Mori, H | 1 |
| Okada, Y | 1 |
| Tanaka, Y | 1 |
| Zinman, B | 1 |
| Haffner, SM | 1 |
| Herman, WH | 1 |
| Holman, RR | 1 |
| Lachin, JM | 1 |
| Kravitz, BG | 1 |
| Paul, G | 1 |
| Jones, NP | 1 |
| Aftring, RP | 1 |
| Viberti, G | 1 |
| Kahn, SE | 1 |
| Lee, YS | 1 |
| Kim, YS | 1 |
| Lee, SY | 1 |
| Kim, GH | 1 |
| Kim, BJ | 1 |
| Lee, SH | 1 |
| Lee, KU | 1 |
| Kim, GS | 1 |
| Kim, SW | 1 |
| Koh, JM | 1 |
| Watts, NB | 1 |
| Blevins, LS | 1 |
1 trial available for metformin and Bone Loss, Osteoclastic
| Article | Year |
|---|---|
Effect of rosiglitazone, metformin, and glyburide on bone biomarkers in patients with type 2 diabetes.
Topics: Adult; Aged; Biomarkers; Bone and Bones; Bone Resorption; Diabetes Mellitus, Type 2; Double-Blind Me | 2010 |
7 other studies available for metformin and Bone Loss, Osteoclastic
| Article | Year |
|---|---|
Metformin attenuates osteoclast-mediated abnormal subchondral bone remodeling and alleviates osteoarthritis via AMPK/NF-κB/ERK signaling pathway.
Topics: AMP-Activated Protein Kinases; Animals; Bone Marrow Cells; Bone Remodeling; Bone Resorption; Extrace | 2021 |
Metformin alleviates bone loss in ovariectomized mice through inhibition of autophagy of osteoclast precursors mediated by E2F1.
Topics: Animals; Autophagy; Bone Resorption; Cell Differentiation; E2F1 Transcription Factor; Female; Humans | 2022 |
Metformin Reduces Bone Resorption in Apical Periodontitis Through Regulation of Osteoblast and Osteoclast Differentiation.
Topics: Animals; Bone Resorption; Cell Differentiation; Core Binding Factor Alpha 1 Subunit; Hypoxia; Metfor | 2023 |
Recommendations on the effect of antidiabetic drugs in bone.
Topics: Aged; Bone Remodeling; Bone Resorption; Contraindications, Drug; Diabetes Mellitus, Type 2; Dipeptid | 2017 |
The Effects of Pioglitazone on Bone Formation and Resorption Markers in Type 2 Diabetes Mellitus.
Topics: Adult; Aged; Bone Resorption; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Male; | 2017 |
AMP kinase acts as a negative regulator of RANKL in the differentiation of osteoclasts.
Topics: Adenylate Kinase; Animals; Apoptosis; Blotting, Western; Bone Resorption; Catechin; Cell Differentia | 2010 |
Endocrinology.
Topics: Bone Resorption; Endocrinology; Graves Disease; Humans; Hyperparathyroidism; Hypoglycemic Agents; Me | 1996 |