metformin has been researched along with B-Cell Chronic Lymphocytic Leukemia in 4 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin was administered in vitro either to quiescent cells or during CLL cell activation stimuli, provided by classical co-culturing with CD40L-expressing fibroblasts." | 5.42 | Metformin inhibits cell cycle progression of B-cell chronic lymphocytic leukemia cells. ( Bruno, S; Casciaro, S; DeCensi, A; Fais, F; Ghiotto, F; Ledda, B; Marini, C; Mazzarello, AN; Orengo, AM; Pesenti, E; Racchi, O; Ravera, S; Sambuceti, G; Tenca, C, 2015) |
| " We observed that Metformin alone exhibited a dose-dependent anti-leukemic activity in both B leukemic cell lines and primary B-chronic lymphocytic leukemia (B-CLL) patients' cells and its anti-leukemic activity was enhanced when used in combination with DCA." | 1.43 | Metformin combined with sodium dichloroacetate promotes B leukemic cell death by suppressing anti-apoptotic protein Mcl-1. ( Bertolasi, V; Casciano, F; Gilli, P; Melloni, E; Rigolin, GM; Rimondi, E; Secchiero, P; Voltan, R; Zauli, G, 2016) |
| "Ritonavir and metformin have been administered in humans for the treatment of diabetes in patients with HIV, demonstrating the tolerance to this combination in humans." | 1.42 | Investigating and targeting chronic lymphocytic leukemia metabolism with the human immunodeficiency virus protease inhibitor ritonavir and metformin. ( Adekola, KU; Dalva Aydemir, S; Ma, S; Rosen, ST; Shanmugam, M; Zhou, Z, 2015) |
| "Metformin was administered in vitro either to quiescent cells or during CLL cell activation stimuli, provided by classical co-culturing with CD40L-expressing fibroblasts." | 1.42 | Metformin inhibits cell cycle progression of B-cell chronic lymphocytic leukemia cells. ( Bruno, S; Casciaro, S; DeCensi, A; Fais, F; Ghiotto, F; Ledda, B; Marini, C; Mazzarello, AN; Orengo, AM; Pesenti, E; Racchi, O; Ravera, S; Sambuceti, G; Tenca, C, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Adekola, KU | 1 |
| Dalva Aydemir, S | 1 |
| Ma, S | 1 |
| Zhou, Z | 1 |
| Rosen, ST | 1 |
| Shanmugam, M | 1 |
| Shi, R | 1 |
| Lin, J | 1 |
| Gong, Y | 1 |
| Yan, T | 1 |
| Shi, F | 1 |
| Yang, X | 1 |
| Liu, X | 1 |
| Naren, D | 1 |
| Bruno, S | 1 |
| Ledda, B | 1 |
| Tenca, C | 1 |
| Ravera, S | 1 |
| Orengo, AM | 1 |
| Mazzarello, AN | 1 |
| Pesenti, E | 1 |
| Casciaro, S | 1 |
| Racchi, O | 1 |
| Ghiotto, F | 1 |
| Marini, C | 1 |
| Sambuceti, G | 1 |
| DeCensi, A | 1 |
| Fais, F | 1 |
| Voltan, R | 1 |
| Rimondi, E | 1 |
| Melloni, E | 1 |
| Gilli, P | 1 |
| Bertolasi, V | 1 |
| Casciano, F | 1 |
| Rigolin, GM | 1 |
| Zauli, G | 1 |
| Secchiero, P | 1 |
4 other studies available for metformin and B-Cell Chronic Lymphocytic Leukemia
| Article | Year |
|---|---|
Investigating and targeting chronic lymphocytic leukemia metabolism with the human immunodeficiency virus protease inhibitor ritonavir and metformin.
Topics: Aged; Cell Survival; Cells, Cultured; Drug Synergism; Energy Metabolism; Female; Glucose; Glucose Tr | 2015 |
The antileukemia effect of metformin in the Philadelphia chromosome-positive leukemia cell line and patient primary leukemia cell.
Topics: Antineoplastic Agents; Autophagy; Benzamides; Drug Resistance, Neoplasm; Drug Synergism; Humans; Ima | 2015 |
Metformin inhibits cell cycle progression of B-cell chronic lymphocytic leukemia cells.
Topics: Cell Cycle; Cell Proliferation; Humans; Hypoglycemic Agents; Leukemia, Lymphocytic, Chronic, B-Cell; | 2015 |
Metformin combined with sodium dichloroacetate promotes B leukemic cell death by suppressing anti-apoptotic protein Mcl-1.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Death; Cell Line, Tumor; Dichloroace | 2016 |