metformin has been researched along with Autism in 7 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Metformin has proven to be beneficial in the treatment of many syndromes, including autism spectrum disorder." | 4.12 | Metformin Alleviates Autistic-Like Behaviors Elicited by High-Fat Diet Consumption and Modulates the Crosstalk Between Serotonin and Gut Microbiota in Mice. ( Chen, Y; Deng, W; Ke, H; Li, F; Li, S; Li, Z; Lv, P; Wang, S, 2022) |
| " In this model, we also examined the medication effects of metformin (Met) which is known to ameliorate several symptoms of autism spectrum disorder (ASD)." | 4.12 | Effect of metformin in autistic BTBR T + Itpr3tf/J mice administered a high-fat diet. ( Chen, Y; Deng, W; Ke, H; Li, F; Li, Z; Lv, P; Wang, S, 2022) |
| " A 16-year-old young-boy, diagnosed with autism, developed diabetes mellitus type 1 whilst he was on treatment with olanzapine (started 4 months before), clomipramine, valproic acid and lithium." | 3.85 | Second-generation antipsychotic and diabetes mellitus in children and adolescents. ( Nurchi, AM; Pinna, AP; Podda, F; Ripoli, C; Tronci, MG; Zanni, R, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 4 (57.14) | 2.80 |
| Authors | Studies |
|---|---|
| Elnahas, EM | 1 |
| Abuelezz, SA | 1 |
| Mohamad, MI | 1 |
| Nabil, MM | 1 |
| Abdelraouf, SM | 1 |
| Bahaa, N | 1 |
| Hassan, GAM | 1 |
| Aboul-Fotouh, S | 1 |
| Deng, W | 2 |
| Ke, H | 2 |
| Wang, S | 2 |
| Li, Z | 2 |
| Li, S | 1 |
| Lv, P | 2 |
| Li, F | 2 |
| Chen, Y | 2 |
| Kopel, J | 1 |
| Grooms, A | 1 |
| Ganapathy, V | 1 |
| Clothier, J | 1 |
| Ripoli, C | 1 |
| Pinna, AP | 1 |
| Podda, F | 1 |
| Zanni, R | 1 |
| Tronci, MG | 1 |
| Nurchi, AM | 1 |
| Gantois, I | 1 |
| Popic, J | 1 |
| Khoutorsky, A | 1 |
| Sonenberg, N | 1 |
| Towbin, KE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multi-center, Prospective, Cohort Study to Elucidate the Effects of Metformin Treatment on Steroid Hormones and Social Behavior. Linking Autistic Behaviorial Symptoms to Changes in Steroid Hormone Availability[NCT04930471] | 45 participants (Anticipated) | Observational | 2021-06-30 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for metformin and Autism
| Article | Year |
|---|---|
Metformin for Treatment of Fragile X Syndrome and Other Neurological Disorders.
Topics: Animals; Autistic Disorder; Disease Models, Animal; Fragile X Mental Retardation Protein; Fragile X | 2019 |
6 other studies available for metformin and Autism
| Article | Year |
|---|---|
Novel role of peroxisome proliferator activated receptor-α in valproic acid rat model of autism: Mechanistic study of risperidone and metformin monotherapy versus combination.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Disease Models, Animal; Fema | 2022 |
Metformin Alleviates Autistic-Like Behaviors Elicited by High-Fat Diet Consumption and Modulates the Crosstalk Between Serotonin and Gut Microbiota in Mice.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Diet, High-Fat; Gastrointestinal Microbiome; M | 2022 |
Effect of metformin in autistic BTBR T + Itpr3tf/J mice administered a high-fat diet.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Diet, High-Fat; Disease Models, Animal; Metfor | 2022 |
Metformin, valproic acid, and starvation induce seizures in a patient with partial SLC13A5 deficiency: a case of pharmaco-synergistic heterozygosity.
Topics: Adult; Amino Acid Substitution; Ammonia; Animals; Anticonvulsants; Autistic Disorder; Bipolar Disord | 2021 |
Second-generation antipsychotic and diabetes mellitus in children and adolescents.
Topics: Adolescent; Antipsychotic Agents; Autistic Disorder; Benzodiazepines; Blood Glucose; Clomipramine; D | 2017 |
Gaining: pediatric patients and use of atypical antipsychotics.
Topics: Adolescent; Adult; Age Factors; Antipsychotic Agents; Autistic Disorder; Body Mass Index; Child; Dia | 2006 |