metformin has been researched along with Atrial Fibrillation in 25 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Atrial Fibrillation: Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Lactic acidosis in diabetic patients undergoing metformin therapy is a widely recognized, rare but usually serious adverse event, particularly in presence of comorbidities such as cardiorespiratory disease, sepsis and renal failure." | 8.88 | Iodine-based radiographic contrast medium may precipitate metformin-associated lactic acidosis in diabetic patients. A case report, literature review and practical approach. ( Tonolini, M, 2012) |
| "To gain insights on the cardiovascular effects of metformin and sulphonylurea, the present study compares the rates of incident atrial fibrillation, stroke, cardiovascular mortality and all-cause mortality between metformin and sulphonylurea users in type 2 diabetes mellitus." | 8.12 | Metformin versus sulphonylureas for new onset atrial fibrillation and stroke in type 2 diabetes mellitus: a population-based study. ( Chang, C; Cheng, SH; Chou, OHI; Lee, S; Leung, KSK; Liu, T; Tse, G; Wai, AKC; Wong, WT; Zhang, G; Zhang, Q; Zhou, J, 2022) |
| "Increased age and the presence of congestive heart failure were associated with significantly higher risk of AF in both groups (HR: 1." | 5.72 | Association between first-line monotherapy with metformin and the risk of atrial fibrillation (AMRAF) in patients with type 2 diabetes. ( Chung, MK; Iqbal, A; Ji, X; Kashyap, SR; Kattan, MW; Milinovich, A; Pantalone, KM; Tekin, Z; Zimmerman, RS, 2022) |
| "Metformin use was associated with a decreased risk of AF in patients with type 2 DM who were not using other anti-diabetic medication, probably via attenuation of atrial cell tachycardia-induced myolysis and oxidative stress." | 5.40 | Association of metformin with lower atrial fibrillation risk among patients with type 2 diabetes mellitus: a population-based dynamic cohort and in vitro studies. ( Chang, SH; Chen, WJ; Chiou, MJ; Kuo, CF; Liu, JR; See, LC; Wen, MS; Wu, LS; Yeh, YH; Yu, KH, 2014) |
| "We sought to determine whether insulin-sensitizing therapy (thiazolidinediones or metformin) decreased the risk of developing atrial fibrillation compared with insulin-providing therapy (insulin, sulfonylurea, or a meglitinide)." | 5.27 | Thiazolidinediones and Risk of Atrial Fibrillation Among Patients with Diabetes and Coronary Disease. ( Boothroyd, DB; Brooks, MM; Chaitman, BR; Hlatky, MA; Pallisgaard, JL; Perez, M, 2018) |
| "Lactic acidosis in diabetic patients undergoing metformin therapy is a widely recognized, rare but usually serious adverse event, particularly in presence of comorbidities such as cardiorespiratory disease, sepsis and renal failure." | 4.88 | Iodine-based radiographic contrast medium may precipitate metformin-associated lactic acidosis in diabetic patients. A case report, literature review and practical approach. ( Tonolini, M, 2012) |
| "To gain insights on the cardiovascular effects of metformin and sulphonylurea, the present study compares the rates of incident atrial fibrillation, stroke, cardiovascular mortality and all-cause mortality between metformin and sulphonylurea users in type 2 diabetes mellitus." | 4.12 | Metformin versus sulphonylureas for new onset atrial fibrillation and stroke in type 2 diabetes mellitus: a population-based study. ( Chang, C; Cheng, SH; Chou, OHI; Lee, S; Leung, KSK; Liu, T; Tse, G; Wai, AKC; Wong, WT; Zhang, G; Zhang, Q; Zhou, J, 2022) |
| "We included 2,515,468 patients with type 2 diabetes from the Korean National Insurance Service database without a history of AF who underwent health check-ups between 2009 and 2012." | 1.91 | Association between antidiabetic drugs and the incidence of atrial fibrillation in patients with type 2 diabetes: A nationwide cohort study in South Korea. ( Cho, W; Han, KD; Kim, B; Kim, JY; Kim, S; Lee, WY; Min, C; Park, SY; Rhee, EJ; Rhee, SY; Yon, DK, 2023) |
| "Increased age and the presence of congestive heart failure were associated with significantly higher risk of AF in both groups (HR: 1." | 1.72 | Association between first-line monotherapy with metformin and the risk of atrial fibrillation (AMRAF) in patients with type 2 diabetes. ( Chung, MK; Iqbal, A; Ji, X; Kashyap, SR; Kattan, MW; Milinovich, A; Pantalone, KM; Tekin, Z; Zimmerman, RS, 2022) |
| "Fibrosis was significantly less in treated mice atria." | 1.62 | Activation of AMP-Activated Protein Kinases Prevents Atrial Fibrillation. ( Dixit, G; Li, Z; Ozcan, C, 2021) |
| "Adaptation of drug dosage to kidney function is a common problem in general practice." | 1.43 | Cardiovascular Drugs and Metformin Drug Dosage According to Renal Function in Non-Institutionalized Elderly Patients. ( Al-Salameh, A; Bauduceau, B; Becquemont, L; Benattar-Zibi, L; Berrut, G; Bertin, P; Bucher, S; Corruble, E; Danchin, N; Derumeaux, G; Doucet, J; Falissard, B; Forette, F; Hanon, O; Ourabah, R; Pasquier, F; Piedvache, C; Pinget, M, 2016) |
| "Metformin use was associated with a decreased risk of AF in patients with type 2 DM who were not using other anti-diabetic medication, probably via attenuation of atrial cell tachycardia-induced myolysis and oxidative stress." | 1.40 | Association of metformin with lower atrial fibrillation risk among patients with type 2 diabetes mellitus: a population-based dynamic cohort and in vitro studies. ( Chang, SH; Chen, WJ; Chiou, MJ; Kuo, CF; Liu, JR; See, LC; Wen, MS; Wu, LS; Yeh, YH; Yu, KH, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (4.00) | 29.6817 |
| 2010's | 8 (32.00) | 24.3611 |
| 2020's | 16 (64.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhou, J | 1 |
| Zhang, G | 1 |
| Chang, C | 1 |
| Chou, OHI | 1 |
| Lee, S | 1 |
| Leung, KSK | 1 |
| Wong, WT | 1 |
| Liu, T | 1 |
| Wai, AKC | 1 |
| Cheng, SH | 1 |
| Zhang, Q | 3 |
| Tse, G | 1 |
| Iqbal, A | 1 |
| Tekin, Z | 1 |
| Kattan, MW | 1 |
| Ji, X | 1 |
| Milinovich, A | 1 |
| Pantalone, KM | 1 |
| Zimmerman, RS | 1 |
| Chung, MK | 2 |
| Kashyap, SR | 1 |
| Lal, JC | 1 |
| Mao, C | 1 |
| Zhou, Y | 1 |
| Gore-Panter, SR | 1 |
| Rennison, JH | 1 |
| Lovano, BS | 1 |
| Castel, L | 1 |
| Shin, J | 1 |
| Gillinov, AM | 1 |
| Smith, JD | 1 |
| Barnard, J | 1 |
| Van Wagoner, DR | 1 |
| Luo, Y | 1 |
| Cheng, F | 1 |
| Vinciguerra, M | 1 |
| Olier, I | 1 |
| Ortega-Martorell, S | 1 |
| Lip, GYH | 2 |
| Kim, S | 1 |
| Park, SY | 1 |
| Kim, B | 1 |
| Min, C | 1 |
| Cho, W | 1 |
| Yon, DK | 1 |
| Kim, JY | 1 |
| Han, KD | 1 |
| Rhee, EJ | 1 |
| Lee, WY | 1 |
| Rhee, SY | 1 |
| Ziyrek, M | 1 |
| Dönmez, E | 1 |
| Özcan, S | 1 |
| Duran, M | 1 |
| Tezcan, H | 1 |
| İnce, O | 1 |
| Özdemir, E | 1 |
| Sahin, I | 1 |
| Okuyan, E | 1 |
| Patti, G | 1 |
| Cerchiara, E | 1 |
| Bressi, E | 1 |
| Giannetti, B | 1 |
| Veneri, AD | 1 |
| Di Sciascio, G | 1 |
| Avvisati, G | 1 |
| De Caterina, R | 1 |
| Liu, Y | 7 |
| Bai, F | 4 |
| Liu, N | 3 |
| Zhang, B | 2 |
| Qin, F | 3 |
| Tu, T | 3 |
| Li, B | 7 |
| Li, J | 10 |
| Ma, Y | 5 |
| Ouyang, F | 1 |
| Liu, Q | 5 |
| Wang, Y | 3 |
| Po, SS | 1 |
| Sun, C | 1 |
| Xiao, Y | 2 |
| Zhou, S | 2 |
| Ozcan, C | 1 |
| Dixit, G | 1 |
| Li, Z | 3 |
| Nguépy Keubo, FR | 1 |
| Mboua, PC | 1 |
| Djifack Tadongfack, T | 1 |
| Fokouong Tchoffo, E | 1 |
| Tasson Tatang, C | 1 |
| Ide Zeuna, J | 1 |
| Noupoue, EM | 1 |
| Tsoplifack, CB | 1 |
| Folefack, GO | 1 |
| Kettani, M | 1 |
| Bandelier, P | 1 |
| Huo, J | 1 |
| Li, H | 4 |
| Yu, D | 1 |
| Arulsamy, N | 1 |
| AlAbbad, S | 1 |
| Sardot, T | 1 |
| Lekashvili, O | 1 |
| Decato, D | 1 |
| Lelj, F | 1 |
| Alexander Ross, JB | 1 |
| Rosenberg, E | 1 |
| Nazir, H | 1 |
| Muthuswamy, N | 1 |
| Louis, C | 1 |
| Jose, S | 1 |
| Prakash, J | 1 |
| Buan, MEM | 1 |
| Flox, C | 1 |
| Chavan, S | 1 |
| Shi, X | 1 |
| Kauranen, P | 1 |
| Kallio, T | 1 |
| Maia, G | 1 |
| Tammeveski, K | 1 |
| Lymperopoulos, N | 1 |
| Carcadea, E | 1 |
| Veziroglu, E | 1 |
| Iranzo, A | 1 |
| M Kannan, A | 1 |
| Arunamata, A | 1 |
| Tacy, TA | 1 |
| Kache, S | 1 |
| Mainwaring, RD | 1 |
| Ma, M | 1 |
| Maeda, K | 1 |
| Punn, R | 1 |
| Noguchi, S | 1 |
| Hahn, S | 3 |
| Iwasa, Y | 3 |
| Ling, J | 2 |
| Voccio, JP | 2 |
| Kim, Y | 3 |
| Song, J | 3 |
| Bascuñán, J | 2 |
| Chu, Y | 1 |
| Tomita, M | 1 |
| Cazorla, M | 1 |
| Herrera, E | 1 |
| Palomeque, E | 1 |
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| Hoplock, LB | 1 |
| Lobchuk, MM | 1 |
| Lemoine, J | 1 |
| Li, X | 10 |
| Henson, MA | 1 |
| Unsihuay, D | 1 |
| Qiu, J | 1 |
| Swaroop, S | 1 |
| Nagornov, KO | 1 |
| Kozhinov, AN | 1 |
| Tsybin, YO | 1 |
| Kuang, S | 1 |
| Laskin, J | 1 |
| Zin, NNINM | 1 |
| Mohamad, MN | 1 |
| Roslan, K | 1 |
| Abdul Wafi, S | 1 |
| Abdul Moin, NI | 1 |
| Alias, A | 1 |
| Zakaria, Y | 1 |
| Abu-Bakar, N | 1 |
| Naveed, A | 1 |
| Jilani, K | 1 |
| Siddique, AB | 1 |
| Akbar, M | 1 |
| Riaz, M | 1 |
| Mushtaq, Z | 1 |
| Sikandar, M | 1 |
| Ilyas, S | 1 |
| Bibi, I | 1 |
| Asghar, A | 1 |
| Rasool, G | 1 |
| Irfan, M | 1 |
| Li, XY | 1 |
| Zhao, S | 1 |
| Fan, XH | 1 |
| Chen, KP | 1 |
| Hua, W | 1 |
| Liu, ZM | 1 |
| Xue, XD | 1 |
| Zhou, B | 1 |
| Zhang, S | 2 |
| Xing, YL | 1 |
| Chen, MA | 1 |
| Sun, Y | 1 |
| Neradilek, MB | 1 |
| Wu, XT | 1 |
| Zhang, D | 3 |
| Huang, W | 1 |
| Cui, Y | 1 |
| Yang, QQ | 1 |
| Li, HW | 1 |
| Zhao, XQ | 1 |
| Hossein Rashidi, B | 1 |
| Tarafdari, A | 1 |
| Ghazimirsaeed, ST | 1 |
| Shahrokh Tehraninezhad, E | 1 |
| Keikha, F | 1 |
| Eslami, B | 1 |
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| Jafarabadi, M | 1 |
| Silvani, Y | 1 |
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| Lemin, AS | 1 |
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| Pangarah, CA | 1 |
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| Zeng, C | 2 |
| Du, H | 1 |
| Lin, D | 1 |
| Jalan, D | 1 |
| Rubagumya, F | 1 |
| Hopman, WM | 1 |
| Vanderpuye, V | 1 |
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| Seruga, B | 1 |
| Booth, CM | 1 |
| Berry, S | 1 |
| Hammad, N | 1 |
| Sajo, EA | 1 |
| Okunade, KS | 1 |
| Olorunfemi, G | 1 |
| Rabiu, KA | 1 |
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| Xu, C | 2 |
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| Dong, X | 1 |
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| Dong, XR | 1 |
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| Tao, F | 1 |
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| Zhao, Y | 2 |
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| Tao, H | 1 |
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| Chen, Y | 3 |
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| Zhao, H | 2 |
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| Ma, Q | 1 |
| Wang, J | 4 |
| Zhang, E | 1 |
| Zhang, J | 3 |
| Li, Y | 5 |
| Xue, F | 1 |
| Deng, L | 1 |
| Liu, L | 2 |
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| Meng, J | 1 |
| Chen, G | 2 |
| Anastassiadou, M | 1 |
| Bernasconi, G | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Efficacy And Safety Of Metformin For The Treatment Of Atrial Fibrillation[NCT05878535] | Phase 4 | 770 participants (Anticipated) | Interventional | 2023-06-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for metformin and Atrial Fibrillation
| Article | Year |
|---|---|
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Comparison of the effect of glucose-lowering agents on the risk of atrial fibrillation: A network meta-analysis.
Topics: Atrial Fibrillation; Bayes Theorem; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformi | 2021 |
Iodine-based radiographic contrast medium may precipitate metformin-associated lactic acidosis in diabetic patients. A case report, literature review and practical approach.
Topics: Acidosis, Lactic; Aged, 80 and over; Atrial Fibrillation; Contraindications; Contrast Media; Creatin | 2012 |
2 trials available for metformin and Atrial Fibrillation
| Article | Year |
|---|---|
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Thiazolidinediones and Risk of Atrial Fibrillation Among Patients with Diabetes and Coronary Disease.
Topics: Atrial Fibrillation; Coronary Disease; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agent | 2018 |
21 other studies available for metformin and Atrial Fibrillation
| Article | Year |
|---|---|
Metformin versus sulphonylureas for new onset atrial fibrillation and stroke in type 2 diabetes mellitus: a population-based study.
Topics: Atrial Fibrillation; Cohort Studies; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Male; M | 2022 |
Association between first-line monotherapy with metformin and the risk of atrial fibrillation (AMRAF) in patients with type 2 diabetes.
Topics: Adult; Atrial Fibrillation; Diabetes Mellitus, Type 2; Heart Failure; Humans; Hypoglycemic Agents; I | 2022 |
Transcriptomics-based network medicine approach identifies metformin as a repurposable drug for atrial fibrillation.
Topics: Atrial Fibrillation; Heart Atria; Humans; Metformin; Transcriptome | 2022 |
New use for an old drug: Metformin and atrial fibrillation.
Topics: Atrial Fibrillation; Diabetes Mellitus, Type 2; Humans; Metformin | 2022 |
Association between antidiabetic drugs and the incidence of atrial fibrillation in patients with type 2 diabetes: A nationwide cohort study in South Korea.
Topics: Aged; Atrial Fibrillation; Cohort Studies; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic A | 2023 |
Effect of SGLT-2 inhibitors as an add-on therapy to metformin on P wave indices and atrial electromechanics in type 2 diabetes mellitus patients.
Topics: Atrial Fibrillation; Diabetes Mellitus, Type 2; Heart Atria; Humans; Metformin; Prospective Studies; | 2023 |
Endothelial Dysfunction, Fibrinolytic Activity, and Coagulation Activity in Patients With Atrial Fibrillation According to Type II Diabetes Mellitus Status.
Topics: Aged; Aged, 80 and over; Anticoagulants; Antithrombins; Atrial Fibrillation; Carboxypeptidase B2; Ca | 2020 |
Metformin improves lipid metabolism and reverses the Warburg effect in a canine model of chronic atrial fibrillation.
Topics: AMP-Activated Protein Kinases; Animals; Atrial Appendage; Atrial Fibrillation; Atrial Function, Left | 2020 |
Metformin therapy confers cardioprotection against the remodeling of gap junction in tachycardia-induced atrial fibrillation dog model.
Topics: AMP-Activated Protein Kinases; Animals; Atrial Fibrillation; Cardiac Pacing, Artificial; Cardiotonic | 2020 |
Metformin regulates adiponectin signalling in epicardial adipose tissue and reduces atrial fibrillation vulnerability.
Topics: 3T3-L1 Cells; Adipocytes; Adiponectin; Adipose Tissue; Animals; Atrial Fibrillation; Atrial Remodeli | 2020 |
Activation of AMP-Activated Protein Kinases Prevents Atrial Fibrillation.
Topics: AMP-Activated Protein Kinases; Animals; Anti-Arrhythmia Agents; Aspirin; Atrial Fibrillation; Atrial | 2021 |
Metformin Is Associated With a Lower Risk of Atrial Fibrillation and Ventricular Arrhythmias Compared With Sulfonylureas: An Observational Study.
Topics: Administration, Oral; Atrial Fibrillation; Databases, Factual; Diabetes Mellitus, Type 2; Drug Thera | 2021 |
Effect of metformin on outcomes of catheter ablation for atrial fibrillation.
Topics: Aged; Atrial Fibrillation; Catheter Ablation; Female; Humans; Metformin; Middle Aged; Recurrence; Ri | 2021 |
Glucose-lowering drug use and new-onset atrial fibrillation in patients with diabetes mellitus.
Topics: Aged; Aged, 80 and over; Atrial Fibrillation; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; | 2021 |
Antihyperglycemic drugs use and new-onset atrial fibrillation in elderly patients.
Topics: Acarbose; Aged; Aged, 80 and over; Atrial Fibrillation; Case-Control Studies; Databases, Factual; Di | 2017 |
Metformin regulates atrial SK2 and SK3 expression through inhibiting the PKC/ERK signaling pathway in type 2 diabetic rats.
Topics: Animals; Atrial Fibrillation; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Extracellu | 2018 |
Metformin regulates lipid metabolism in a canine model of atrial fibrillation through AMPK/PPAR-α/VLCAD pathway.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; AMP-Activated Protein Kinases; Animals; Atrial Fibrillation; Car | 2019 |
Association of metformin with lower atrial fibrillation risk among patients with type 2 diabetes mellitus: a population-based dynamic cohort and in vitro studies.
Topics: Adult; Aged; Atrial Fibrillation; Cohort Studies; Diabetes Mellitus, Type 2; Female; Follow-Up Studi | 2014 |
Impact of comorbidities and use of common medications on cancer and non-cancer specific survival in esophageal carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Angiotensin Receptor Antagonists; Anti-Inflammatory Agents, Non-Ster | 2015 |
Cardiovascular Drugs and Metformin Drug Dosage According to Renal Function in Non-Institutionalized Elderly Patients.
Topics: Aged; Aged, 80 and over; Atrial Fibrillation; Cardiovascular Agents; Cohort Studies; Diabetes Mellit | 2016 |
Hypoglycaemia induced by disopyramide in a patient with Type 2 diabetes mellitus.
Topics: Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Diabetes Mellitus, Type 2; Disopyramide; Drug The | 2001 |