metformin has been researched along with Asystole in 21 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin-associated lactic acidosis (MALA) is a serious condition with high mortality." | 8.31 | Surviving cardiac arrest from severe metformin-associated lactic acidosis using extracorporeal membrane oxygenation and double continuous venovenous haemodialysis. ( Akkaoui, KK; Andersen, LV; Andreasen, JB; Nørgaard, MA, 2023) |
| " Metformin-associated lactic acidosis (MALA) is one such rare, life-threatening adverse drug effect." | 7.88 | Metformin-associated lactic acidosis precipitated by liraglutide use: adverse effects of aggressive antihyperglycaemic therapy. ( Hannallah, F; Hooda, A; Mehta, A, 2018) |
| "Metformin-associated lactic acidosis is a diagnosis by exclusion; however, a high degree of clinical suspicion supplemented by prompt multisystem organ support can significantly influence the outcome in critically ill patients." | 7.80 | Metformin-associated lactic acidosis presenting as an ischemic gut in a patient who then survived a cardiac arrest: a case report. ( Ncomanzi, D; Sicat, RM; Sundararajan, K, 2014) |
| " There was concomitant ACE inhibitor (ACEi) use and metformin toxicity with severe lactic acidosis." | 7.79 | Feeling blue with metformin-associated lactic acidosis. ( Parker, A; Plumb, B; Wong, P, 2013) |
| " We present a case of a 65-year-old Caucasian man who presented with metformin associated lactic acidosis." | 7.78 | Survival after cardiopulmonary arrest with extreme hyperkalaemia and hypothermia in a patient with metformin-associated lactic acidosis. ( Lee, IL; Tay, S, 2012) |
| "Metformin associated lactic acidosis (MALA) is a rare condition with a prevalence of 3 per 100,000 patient-years." | 7.76 | [Metformin treatment causes persisting lactic acidosis after cardiac arrest]. ( Gamst, J; Hansen, LK; Rasmussen, BS, 2010) |
| "We report 4 cases of lactic acidosis in diabetic patients usually treated with metformin." | 7.72 | [Metformin-associated lactic acidosis remains a serious complication of metformin therapy]. ( Giunti, C; Grimaud, D; Ichai, C; Levraut, J; Orban, JC, 2003) |
| "Lactic acidosis is a recognised complication of the antihyperglycaemic biguanide agent metformin, especially in patients with renal failure." | 7.72 | Unexpected survival from severe metformin-associated lactic acidosis. ( de Gooijer, A; Schure, PJ; van Zanten, AR, 2003) |
| "Metformin-associated lactic acidosis (MALA) is a serious condition with high mortality." | 4.31 | Surviving cardiac arrest from severe metformin-associated lactic acidosis using extracorporeal membrane oxygenation and double continuous venovenous haemodialysis. ( Akkaoui, KK; Andersen, LV; Andreasen, JB; Nørgaard, MA, 2023) |
| " Metformin-associated lactic acidosis (MALA) is one such rare, life-threatening adverse drug effect." | 3.88 | Metformin-associated lactic acidosis precipitated by liraglutide use: adverse effects of aggressive antihyperglycaemic therapy. ( Hannallah, F; Hooda, A; Mehta, A, 2018) |
| "Metformin-associated lactic acidosis is a diagnosis by exclusion; however, a high degree of clinical suspicion supplemented by prompt multisystem organ support can significantly influence the outcome in critically ill patients." | 3.80 | Metformin-associated lactic acidosis presenting as an ischemic gut in a patient who then survived a cardiac arrest: a case report. ( Ncomanzi, D; Sicat, RM; Sundararajan, K, 2014) |
| " There was concomitant ACE inhibitor (ACEi) use and metformin toxicity with severe lactic acidosis." | 3.79 | Feeling blue with metformin-associated lactic acidosis. ( Parker, A; Plumb, B; Wong, P, 2013) |
| " We present a case of a 65-year-old Caucasian man who presented with metformin associated lactic acidosis." | 3.78 | Survival after cardiopulmonary arrest with extreme hyperkalaemia and hypothermia in a patient with metformin-associated lactic acidosis. ( Lee, IL; Tay, S, 2012) |
| "Metformin associated lactic acidosis (MALA) is a rare condition with a prevalence of 3 per 100,000 patient-years." | 3.76 | [Metformin treatment causes persisting lactic acidosis after cardiac arrest]. ( Gamst, J; Hansen, LK; Rasmussen, BS, 2010) |
| "We report 4 cases of lactic acidosis in diabetic patients usually treated with metformin." | 3.72 | [Metformin-associated lactic acidosis remains a serious complication of metformin therapy]. ( Giunti, C; Grimaud, D; Ichai, C; Levraut, J; Orban, JC, 2003) |
| "Lactic acidosis is a recognised complication of the antihyperglycaemic biguanide agent metformin, especially in patients with renal failure." | 3.72 | Unexpected survival from severe metformin-associated lactic acidosis. ( de Gooijer, A; Schure, PJ; van Zanten, AR, 2003) |
| "Metformin has shown cardioprotective and neuroprotective effects in cardiac arrest and ischemia-reperfusion injury animal models." | 1.91 | Association between metformin and survival outcomes in in-hospital cardiac arrest patients with diabetes. ( Ahn, S; Cho, H; Jin, BY; Kim, DH; Kim, J; Kim, SJ; Moon, S; Park, JH; Song, J, 2023) |
| "Metformin pretreatment may offer cardiac and renal protection for diabetic patients during sudden cardiac arrest." | 1.72 | Metformin protects against cardiac and renal damage in diabetic cardiac arrest patients. ( Dezfulian, C; Elmer, J; Kaufman, BA; Rutledge, CA, 2022) |
| "Metformin, a first-line treatment for diabetes, has shown promising results in the treatment for other diseases and is known to interact with the mitochondria." | 1.72 | Metformin-mediated mitochondrial protection post-cardiac arrest improves EEG activity and confers neuroprotection and survival benefit. ( Becker, LB; Chillale, RK; Choudhary, RC; Frankfurt, M; Haque, S; Kim, J; Kim, N; Miyara, SJ; Molmenti, EP; Shoaib, M; Yin, T; Zanos, S, 2022) |
| "Sudden cardiac arrest (CA) often results in severe injury to the brain, and neuroprotection after CA has proved to be difficult to achieve." | 1.48 | Metformin Improves Neurologic Outcome Via AMP-Activated Protein Kinase-Mediated Autophagy Activation in a Rat Model of Cardiac Arrest and Resuscitation. ( Gu, Y; Hu, Y; Huang, K; Ji, Z; Liu, K; Pan, S; Zhu, J, 2018) |
| "Thirty (39%) patients suffered cardiac arrest before admission." | 1.43 | Prognosis of patients presenting extreme acidosis (pH <7) on admission to intensive care unit. ( Allou, N; Allyn, J; Brulliard, C; Combe, P; Galliot, R; Jabot, J; Martinet, O; Tabatchnik, X; Vandroux, D, 2016) |
| "Metformin is an oral antihyperglycemic agent used in the management of type 2 diabetes mellitus." | 1.40 | Fatal metformin overdose: case report and postmortem biochemistry contribution. ( Bonsignore, A; Fraternali Orcioni, G; Palmiere, C; Pozzi, F; Ventura, F, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (14.29) | 29.6817 |
| 2010's | 12 (57.14) | 24.3611 |
| 2020's | 6 (28.57) | 2.80 |
| Authors | Studies |
|---|---|
| Rutledge, CA | 1 |
| Kaufman, BA | 1 |
| Dezfulian, C | 1 |
| Elmer, J | 1 |
| Shoaib, M | 1 |
| Choudhary, RC | 1 |
| Chillale, RK | 1 |
| Kim, N | 1 |
| Miyara, SJ | 1 |
| Haque, S | 1 |
| Yin, T | 1 |
| Frankfurt, M | 1 |
| Molmenti, EP | 1 |
| Zanos, S | 1 |
| Kim, J | 2 |
| Becker, LB | 1 |
| Jin, BY | 1 |
| Song, J | 1 |
| Park, JH | 1 |
| Kim, SJ | 1 |
| Cho, H | 1 |
| Moon, S | 1 |
| Kim, DH | 1 |
| Ahn, S | 1 |
| Honore, PM | 1 |
| Bousbiat, I | 1 |
| Perriens, E | 1 |
| Blackman, S | 1 |
| Akkaoui, KK | 1 |
| Andersen, LV | 1 |
| Nørgaard, MA | 1 |
| Andreasen, JB | 1 |
| Gonçalves, BM | 1 |
| Coelho, D | 1 |
| Do, JY | 1 |
| Kim, SW | 1 |
| Park, JW | 1 |
| Cho, KH | 1 |
| Kang, SH | 1 |
| Zhu, J | 1 |
| Liu, K | 1 |
| Huang, K | 1 |
| Gu, Y | 1 |
| Hu, Y | 1 |
| Pan, S | 1 |
| Ji, Z | 1 |
| Hooda, A | 1 |
| Mehta, A | 1 |
| Hannallah, F | 1 |
| Schuenemeyer, JW | 1 |
| Jette-Kelly, LA | 1 |
| Plumb, B | 1 |
| Parker, A | 1 |
| Wong, P | 1 |
| Bonsignore, A | 1 |
| Pozzi, F | 1 |
| Fraternali Orcioni, G | 1 |
| Ventura, F | 1 |
| Palmiere, C | 1 |
| Ncomanzi, D | 1 |
| Sicat, RM | 1 |
| Sundararajan, K | 1 |
| Allyn, J | 1 |
| Vandroux, D | 1 |
| Jabot, J | 1 |
| Brulliard, C | 1 |
| Galliot, R | 1 |
| Tabatchnik, X | 1 |
| Combe, P | 1 |
| Martinet, O | 1 |
| Allou, N | 1 |
| Ebrahim, I | 1 |
| Blockman, M | 1 |
| Gamst, J | 1 |
| Hansen, LK | 1 |
| Rasmussen, BS | 1 |
| von Eyben, FE | 1 |
| Tay, S | 1 |
| Lee, IL | 1 |
| Orban, JC | 1 |
| Giunti, C | 1 |
| Levraut, J | 1 |
| Grimaud, D | 1 |
| Ichai, C | 1 |
| Schure, PJ | 1 |
| de Gooijer, A | 1 |
| van Zanten, AR | 1 |
| Jain, V | 1 |
| Sharma, D | 1 |
| Prabhakar, H | 1 |
| Dash, HH | 1 |
21 other studies available for metformin and Asystole
| Article | Year |
|---|---|
Metformin protects against cardiac and renal damage in diabetic cardiac arrest patients.
Topics: Creatinine; Diabetes Mellitus; Heart Arrest; Humans; Hypoglycemic Agents; Kidney; Metformin; Retrosp | 2022 |
Metformin-mediated mitochondrial protection post-cardiac arrest improves EEG activity and confers neuroprotection and survival benefit.
Topics: Animals; Brain Injuries; Disease Models, Animal; Electroencephalography; Heart Arrest; Humans; Metfo | 2022 |
Association between metformin and survival outcomes in in-hospital cardiac arrest patients with diabetes.
Topics: Cardiopulmonary Resuscitation; Diabetes Mellitus, Type 2; Heart Arrest; Hospitals; Humans; Metformin | 2023 |
Letter to the Editor: "Association between metformin and survival outcomes in in-hospital cardiac arrest patients with diabetes".
Topics: Cardiopulmonary Resuscitation; Diabetes Mellitus; Heart Arrest; Hospitals; Humans; Metformin | 2023 |
Surviving cardiac arrest from severe metformin-associated lactic acidosis using extracorporeal membrane oxygenation and double continuous venovenous haemodialysis.
Topics: Acidosis, Lactic; Continuous Renal Replacement Therapy; Extracorporeal Membrane Oxygenation; Heart A | 2023 |
Metformin-associated lactic acidosis: A case reporting a serious complication in the perioperative period.
Topics: Acidosis, Lactic; Aged; Anuria; Diabetes Mellitus, Type 2; Female; Heart Arrest; Humans; Hypoglycemi | 2019 |
Is there an association between metformin use and clinical outcomes in diabetes patients with COVID-19?
Topics: Acute Kidney Injury; Adult; Aged; Cardiotonic Agents; COVID-19; Diabetes Mellitus, Type 2; Extracorp | 2021 |
Metformin Improves Neurologic Outcome Via AMP-Activated Protein Kinase-Mediated Autophagy Activation in a Rat Model of Cardiac Arrest and Resuscitation.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Autophagy; Brain Ischemia; CA1 Region, Hippocampa | 2018 |
Metformin-associated lactic acidosis precipitated by liraglutide use: adverse effects of aggressive antihyperglycaemic therapy.
Topics: Acidosis, Lactic; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Drug-Related Side Effects and Adve | 2018 |
A 35-Year-Old Woman With Shock, Pulseless Electrical Activity Arrest, and Hemodynamic Collapse.
Topics: Abdominal Pain; Acidosis, Lactic; Adult; Diabetes Mellitus, Type 2; Diagnosis, Differential; Drug-Re | 2019 |
Feeling blue with metformin-associated lactic acidosis.
Topics: Acidosis, Lactic; Aged; Cardiopulmonary Resuscitation; Enzyme Inhibitors; Female; Heart Arrest; Huma | 2013 |
Fatal metformin overdose: case report and postmortem biochemistry contribution.
Topics: Acidosis, Lactic; Aged; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 2; Drug Overdo | 2014 |
Metformin-associated lactic acidosis presenting as an ischemic gut in a patient who then survived a cardiac arrest: a case report.
Topics: Acidosis, Lactic; Aged; Diabetes Mellitus, Type 2; Female; Heart Arrest; Humans; Hypoglycemic Agents | 2014 |
Prognosis of patients presenting extreme acidosis (pH <7) on admission to intensive care unit.
Topics: Acidosis; Acidosis, Lactic; Acidosis, Respiratory; Adult; Aged; Diabetes Mellitus; Extracorporeal Me | 2016 |
Metabolic acidosis in a patient with metformin overdose.
Topics: Acidosis; Blood Gas Analysis; Cardiotonic Agents; Drug Overdose; Fatal Outcome; Female; Heart Arrest | 2017 |
[Metformin treatment causes persisting lactic acidosis after cardiac arrest].
Topics: Acidosis, Lactic; Cardiopulmonary Resuscitation; Diabetes Mellitus, Type 2; Fatal Outcome; Heart Arr | 2010 |
[Short-lasting lactic acidosis after heart arrest].
Topics: Acidosis, Lactic; Heart Arrest; Humans; Hypoglycemic Agents; Metformin | 2011 |
Survival after cardiopulmonary arrest with extreme hyperkalaemia and hypothermia in a patient with metformin-associated lactic acidosis.
Topics: Acidosis, Lactic; Aged; Cardiopulmonary Resuscitation; Heart Arrest; Humans; Hyperkalemia; Hypoglyce | 2012 |
[Metformin-associated lactic acidosis remains a serious complication of metformin therapy].
Topics: Acidosis, Lactic; Acute Kidney Injury; Adult; Aged; Diabetes Complications; Diabetes Mellitus, Type | 2003 |
Unexpected survival from severe metformin-associated lactic acidosis.
Topics: Acidosis, Lactic; Aged; Contraindications; Diabetic Nephropathies; Female; Heart Arrest; Humans; Hyp | 2003 |
Metformin-associated lactic acidosis following contrast media-induced nephrotoxicity.
Topics: Acidosis, Lactic; Angiography, Digital Subtraction; Blood Gas Analysis; Contrast Media; Diabetes Mel | 2008 |