metformin has been researched along with Astrocytoma, Grade IV in 39 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Memantine, mefloquine, and metformin can be combined safely with TMZ in patients with newly diagnosed glioblastoma." | 9.30 | Phase 1 lead-in to a phase 2 factorial study of temozolomide plus memantine, mefloquine, and metformin as postradiation adjuvant therapy for newly diagnosed glioblastoma. ( Aldape, KD; Alfred Yung, WK; Conrad, CA; de Groot, JF; Gilbert, MR; Groves, MD; Hess, KR; Loghin, ME; Mammoser, AG; Maraka, S; Melguizo-Gavilanes, I; O'Brien, BJ; Penas-Prado, M; Puduvalli, VK; Sulman, EP; Tremont-Lukats, IW, 2019) |
| "An exploratory-observational-randomized retrospective glioblastoma patient cohort (n = 85), human glioblastoma/non-tumour brain human cells (cell lines/patient-derived cell cultures), mouse astrocytes progenitor cell cultures, and a preclinical xenograft glioblastoma mouse model were used to measure key functional parameters, signalling-pathways and/or antitumour progression in response to metformin and/or simvastatin." | 8.31 | Metformin and simvastatin exert additive antitumour effects in glioblastoma via senescence-state: clinical and translational evidence. ( Blanco-Acevedo, C; Castaño, JP; Doval-Rosa, C; Fuentes-Fayos, AC; G-García, ME; Gahete, MD; Jiménez-Vacas, JM; López, M; Luque, RM; Martín-Colom, J; Montero-Hidalgo, AJ; Ortega-Salas, RM; Peralbo-Santaella, E; Pérez-Gómez, JM; Sánchez-Sánchez, R; Solivera, J; Tena-Sempere, M; Toledano-Delgado, Á; Torres, E, 2023) |
| "New treatments are needed to improve the overall survival of patients with glioblastoma Metformin is known for anti-tumorigenic effects in cancers, including breast and pancreas cancers." | 8.31 | Metformin use is associated with longer survival in glioblastoma patients with MGMT gene silencing. ( Al-Saadi, T; Diaz, RJ; Jatana, S; Khalaf, R; Mohammad, AH; Ruiz-Barerra, MA, 2023) |
| "To investigate the effects of metformin, dichloroacetate (DCA), and memantine on T98G and U87-MG human glioblastoma (GBM) cells to target tumor cell metabolism in a multi-directional manner." | 8.02 | Targeting Cancer Cell Metabolism with Metformin, Dichloroacetate and Memantine in Glioblastoma (GBM). ( Albayrak, G; Dere, UA; Emmez, H; Konac, E, 2021) |
| "The purpose of the study is to investigate the efficacy of combined treatment with temozolomide (TMZ) and metformin for glioblastoma (GBM) in vitro and in vivo." | 7.88 | High-Dose Metformin Plus Temozolomide Shows Increased Anti-tumor Effects in Glioblastoma In Vitro and In Vivo Compared with Monotherapy. ( Hong, YK; Lee, JE; Lim, JH; Yang, SH, 2018) |
| "The present study was designed to evaluate the effects of irinotecan hydrochloride (IRI)- or metformin hydrochloride (MET)-loaded poly-lactic-co-glycolic acid (PLGA) nanoparticles (NPs) for the treatment of glioblastoma multiforme using in vitro neuron and U-87 MG glioblastoma cell cultures and in vivo animal model." | 7.88 | Effect of metformin/irinotecan-loaded poly-lactic-co-glycolic acid nanoparticles on glioblastoma: in vitro and in vivo studies. ( Abd El-Aty, AM; Cetin, M; Galateanu, B; Gundogdu, B; Hacimuftuoglu, A; Jeong, JH; Jung, TW; Mezhuev, Y; Mohammadzadeh, M; Nalci, KA; Okkay, U; Stivaktakis, P; Taghizadehghalehjoughi, A; Taspinar, M; Taspinar, N; Tsatsakis, A; Ugur, AB; Uyanik, A, 2018) |
| "It has been reported that metformin acts synergistically with temozolomide (TMZ) to inhibit proliferation of glioma cells including glioblastoma multiforme (GBM)." | 7.83 | Metformin treatment reduces temozolomide resistance of glioblastoma cells. ( Kim, DH; Li, S; Liu, Y; Lu, G; Xue, H; Yang, SH; Zhu, JJ, 2016) |
| "High-grade gliomas, glioblastomas (GB), are refractory to conventional treatment combining surgery, chemotherapy, mainly temozolomide, and radiotherapy." | 7.81 | Metformin inhibits growth of human glioblastoma cells and enhances therapeutic response. ( Brem, H; Cohen-Jonathan Moyal, E; Dahan, P; Dang, VT; Lemarié, A; Saland, E; Sarry, JE; Scotland, SJ; Sesen, J; Skuli, N; Toulas, C; Tyler, BM, 2015) |
| " Interestingly, our findings showed an association of metformin therapy and prolonged progression-free survival in glioblastoma patients with diabetes and therefore serve as a foundation for further preclinical and clinical investigations." | 7.81 | Metformin influences progression in diabetic glioblastoma patients. ( Adeberg, S; Ben Harrabi, S; Bernhardt, D; Bostel, T; Debus, J; Diehl, C; Koelsche, C; Mohr, A; Rieken, S, 2015) |
| "Metformin (MET) has been shown to suppress the proliferative capacity and invasion ability of GBM cells by activating AMPK and inhibiting mTOR, but the effective dose exceeded the maximum tolerated dose." | 5.91 | Lower dose of metformin combined with artesunate induced autophagy-dependent apoptosis of glioblastoma by activating ROS-AMPK-mTOR axis. ( Ding, W; Liao, L; Liao, Y; Liu, J; Tang, Q; Zhao, J, 2023) |
| "Metformin is a biguanide drug utilized as the first-line medication in treating type 2 diabetes." | 5.72 | Exploring the Mechanism of Adjuvant Treatment of Glioblastoma Using Temozolomide and Metformin. ( Chang, PC; Chen, HY; Feng, SW; Huang, SM; Hueng, DY; Li, YF, 2022) |
| "Metformin has long been an attractive therapeutic option for EwS, but hypoxia limits its efficacy." | 5.56 | Imatinib revives the therapeutic potential of metformin on ewing sarcoma by attenuating tumor hypoxic response and inhibiting convergent signaling pathways. ( Cheng, H; Lau, CC; Nan, X; Qiu, B; Sheng, J; Wang, J; Wong, STC; Yin, Z; Yustein, JT; Zhao, H, 2020) |
| "Metformin has been linked to improve survival of patients with various cancers." | 5.56 | Use of metformin and outcome of patients with newly diagnosed glioblastoma: Pooled analysis. ( Chinot, O; Genbrugge, E; Gorlia, T; Hau, P; Nabors, B; Seliger, C; Stupp, R; Weller, M, 2020) |
| "Memantine, mefloquine, and metformin can be combined safely with TMZ in patients with newly diagnosed glioblastoma." | 5.30 | Phase 1 lead-in to a phase 2 factorial study of temozolomide plus memantine, mefloquine, and metformin as postradiation adjuvant therapy for newly diagnosed glioblastoma. ( Aldape, KD; Alfred Yung, WK; Conrad, CA; de Groot, JF; Gilbert, MR; Groves, MD; Hess, KR; Loghin, ME; Mammoser, AG; Maraka, S; Melguizo-Gavilanes, I; O'Brien, BJ; Penas-Prado, M; Puduvalli, VK; Sulman, EP; Tremont-Lukats, IW, 2019) |
| "An exploratory-observational-randomized retrospective glioblastoma patient cohort (n = 85), human glioblastoma/non-tumour brain human cells (cell lines/patient-derived cell cultures), mouse astrocytes progenitor cell cultures, and a preclinical xenograft glioblastoma mouse model were used to measure key functional parameters, signalling-pathways and/or antitumour progression in response to metformin and/or simvastatin." | 4.31 | Metformin and simvastatin exert additive antitumour effects in glioblastoma via senescence-state: clinical and translational evidence. ( Blanco-Acevedo, C; Castaño, JP; Doval-Rosa, C; Fuentes-Fayos, AC; G-García, ME; Gahete, MD; Jiménez-Vacas, JM; López, M; Luque, RM; Martín-Colom, J; Montero-Hidalgo, AJ; Ortega-Salas, RM; Peralbo-Santaella, E; Pérez-Gómez, JM; Sánchez-Sánchez, R; Solivera, J; Tena-Sempere, M; Toledano-Delgado, Á; Torres, E, 2023) |
| "New treatments are needed to improve the overall survival of patients with glioblastoma Metformin is known for anti-tumorigenic effects in cancers, including breast and pancreas cancers." | 4.31 | Metformin use is associated with longer survival in glioblastoma patients with MGMT gene silencing. ( Al-Saadi, T; Diaz, RJ; Jatana, S; Khalaf, R; Mohammad, AH; Ruiz-Barerra, MA, 2023) |
| "To investigate the effects of metformin, dichloroacetate (DCA), and memantine on T98G and U87-MG human glioblastoma (GBM) cells to target tumor cell metabolism in a multi-directional manner." | 4.02 | Targeting Cancer Cell Metabolism with Metformin, Dichloroacetate and Memantine in Glioblastoma (GBM). ( Albayrak, G; Dere, UA; Emmez, H; Konac, E, 2021) |
| " Thus, in the current study, we aimed to investigate the effects of metformin on the development of morphine and/or methadone-induced tolerance in human glioblastoma (T98G) cell line." | 3.91 | In vitro evaluation of effects of metformin on morphine and methadone tolerance through mammalian target of rapamycin signaling pathway. ( Dehpour, AR; Esmaeili, J; Sahebgharani, M; Shirooie, S, 2019) |
| "The purpose of the study is to investigate the efficacy of combined treatment with temozolomide (TMZ) and metformin for glioblastoma (GBM) in vitro and in vivo." | 3.88 | High-Dose Metformin Plus Temozolomide Shows Increased Anti-tumor Effects in Glioblastoma In Vitro and In Vivo Compared with Monotherapy. ( Hong, YK; Lee, JE; Lim, JH; Yang, SH, 2018) |
| "The present study was designed to evaluate the effects of irinotecan hydrochloride (IRI)- or metformin hydrochloride (MET)-loaded poly-lactic-co-glycolic acid (PLGA) nanoparticles (NPs) for the treatment of glioblastoma multiforme using in vitro neuron and U-87 MG glioblastoma cell cultures and in vivo animal model." | 3.88 | Effect of metformin/irinotecan-loaded poly-lactic-co-glycolic acid nanoparticles on glioblastoma: in vitro and in vivo studies. ( Abd El-Aty, AM; Cetin, M; Galateanu, B; Gundogdu, B; Hacimuftuoglu, A; Jeong, JH; Jung, TW; Mezhuev, Y; Mohammadzadeh, M; Nalci, KA; Okkay, U; Stivaktakis, P; Taghizadehghalehjoughi, A; Taspinar, M; Taspinar, N; Tsatsakis, A; Ugur, AB; Uyanik, A, 2018) |
| "It has been reported that metformin acts synergistically with temozolomide (TMZ) to inhibit proliferation of glioma cells including glioblastoma multiforme (GBM)." | 3.83 | Metformin treatment reduces temozolomide resistance of glioblastoma cells. ( Kim, DH; Li, S; Liu, Y; Lu, G; Xue, H; Yang, SH; Zhu, JJ, 2016) |
| "High-grade gliomas, glioblastomas (GB), are refractory to conventional treatment combining surgery, chemotherapy, mainly temozolomide, and radiotherapy." | 3.81 | Metformin inhibits growth of human glioblastoma cells and enhances therapeutic response. ( Brem, H; Cohen-Jonathan Moyal, E; Dahan, P; Dang, VT; Lemarié, A; Saland, E; Sarry, JE; Scotland, SJ; Sesen, J; Skuli, N; Toulas, C; Tyler, BM, 2015) |
| " Interestingly, our findings showed an association of metformin therapy and prolonged progression-free survival in glioblastoma patients with diabetes and therefore serve as a foundation for further preclinical and clinical investigations." | 3.81 | Metformin influences progression in diabetic glioblastoma patients. ( Adeberg, S; Ben Harrabi, S; Bernhardt, D; Bostel, T; Debus, J; Diehl, C; Koelsche, C; Mohr, A; Rieken, S, 2015) |
| "Metformin treatment led to increased autophagy and strong inhibition of carbon flux from glucose to amino acids in all subtypes." | 1.91 | Heterogeneity of Amino Acid Profiles of Proneural and Mesenchymal Brain-Tumor Initiating Cells. ( Ammer, LM; Dettmer, K; Hau, P; Heckscher, S; Jachnik, B; Leidgens, V; Moeckel, S; Oefner, PJ; Proescholdt, M; Rauer, L; Riemenschneider, MJ; Seliger, C; Vollmann-Zwerenz, A; Wüster, AL, 2023) |
| "Metformin (MET) has been shown to suppress the proliferative capacity and invasion ability of GBM cells by activating AMPK and inhibiting mTOR, but the effective dose exceeded the maximum tolerated dose." | 1.91 | Lower dose of metformin combined with artesunate induced autophagy-dependent apoptosis of glioblastoma by activating ROS-AMPK-mTOR axis. ( Ding, W; Liao, L; Liao, Y; Liu, J; Tang, Q; Zhao, J, 2023) |
| "Metformin is a biguanide drug utilized as the first-line medication in treating type 2 diabetes." | 1.72 | Exploring the Mechanism of Adjuvant Treatment of Glioblastoma Using Temozolomide and Metformin. ( Chang, PC; Chen, HY; Feng, SW; Huang, SM; Hueng, DY; Li, YF, 2022) |
| "Metformin has long been an attractive therapeutic option for EwS, but hypoxia limits its efficacy." | 1.56 | Imatinib revives the therapeutic potential of metformin on ewing sarcoma by attenuating tumor hypoxic response and inhibiting convergent signaling pathways. ( Cheng, H; Lau, CC; Nan, X; Qiu, B; Sheng, J; Wang, J; Wong, STC; Yin, Z; Yustein, JT; Zhao, H, 2020) |
| "Metformin has been linked to improve survival of patients with various cancers." | 1.56 | Use of metformin and outcome of patients with newly diagnosed glioblastoma: Pooled analysis. ( Chinot, O; Genbrugge, E; Gorlia, T; Hau, P; Nabors, B; Seliger, C; Stupp, R; Weller, M, 2020) |
| "Treatment with metformin reduced STAT3-phosphorylation in all investigated BTICs and TCs." | 1.46 | Stattic and metformin inhibit brain tumor initiating cells by reducing STAT3-phosphorylation. ( Bogdahn, U; Hau, P; Leidgens, V; Moeckel, S; Proescholdt, M; Proske, J; Rauer, L; Renner, K; Riemenschneider, MJ; Seliger, C; Vollmann-Zwerenz, A, 2017) |
| "Metformin or olanzapine have been shown independently to enhance AMPK activation." | 1.37 | Can the therapeutic effects of temozolomide be potentiated by stimulating AMP-activated protein kinase with olanzepine and metformin? ( Halatsch, ME; Karpel-Massler, G; Kast, RE, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 22 (56.41) | 24.3611 |
| 2020's | 17 (43.59) | 2.80 |
| Authors | Studies |
|---|---|
| Zhan, Q | 1 |
| Yi, K | 1 |
| Cui, X | 1 |
| Li, X | 11 |
| Yang, S | 2 |
| Wang, Q | 3 |
| Fang, C | 1 |
| Tan, Y | 1 |
| Li, L | 1 |
| Xu, C | 3 |
| Yuan, X | 1 |
| Kang, C | 1 |
| Sanati, M | 1 |
| Aminyavari, S | 1 |
| Mollazadeh, H | 1 |
| Motamed-Sanaye, A | 1 |
| Bibak, B | 1 |
| Mohtashami, E | 1 |
| Teng, Y | 1 |
| Afshari, AR | 1 |
| Sahebkar, A | 2 |
| Feng, SW | 1 |
| Chang, PC | 1 |
| Chen, HY | 1 |
| Hueng, DY | 1 |
| Li, YF | 1 |
| Huang, SM | 1 |
| Zhu, L | 1 |
| Liu, J | 2 |
| Qiu, M | 1 |
| Chen, J | 2 |
| Liang, Q | 1 |
| Peng, G | 1 |
| Zou, Z | 1 |
| Felker, J | 1 |
| Agnihotri, S | 1 |
| Seliger, C | 5 |
| Meyer, AL | 2 |
| Leidgens, V | 4 |
| Rauer, L | 4 |
| Moeckel, S | 4 |
| Jachnik, B | 3 |
| Proske, J | 2 |
| Dettmer, K | 3 |
| Rothhammer-Hampl, T | 1 |
| Kaulen, LD | 1 |
| Riemenschneider, MJ | 4 |
| Oefner, PJ | 3 |
| Kreutz, M | 2 |
| Schmidt, NO | 1 |
| Merrill, M | 1 |
| Uhl, M | 2 |
| Renner, K | 3 |
| Vollmann-Zwerenz, A | 4 |
| Proescholdt, M | 4 |
| Hau, P | 5 |
| Wüster, AL | 1 |
| Ammer, LM | 1 |
| Heckscher, S | 1 |
| Fuentes-Fayos, AC | 1 |
| G-García, ME | 1 |
| Pérez-Gómez, JM | 1 |
| Montero-Hidalgo, AJ | 1 |
| Martín-Colom, J | 1 |
| Doval-Rosa, C | 1 |
| Blanco-Acevedo, C | 1 |
| Torres, E | 1 |
| Toledano-Delgado, Á | 1 |
| Sánchez-Sánchez, R | 1 |
| Peralbo-Santaella, E | 1 |
| Ortega-Salas, RM | 1 |
| Jiménez-Vacas, JM | 1 |
| Tena-Sempere, M | 1 |
| López, M | 1 |
| Castaño, JP | 1 |
| Gahete, MD | 1 |
| Solivera, J | 1 |
| Luque, RM | 1 |
| Ailuno, G | 1 |
| Baldassari, S | 1 |
| Balboni, A | 1 |
| Drava, G | 1 |
| Spalletti, C | 1 |
| Tantillo, E | 1 |
| Mazzanti, M | 2 |
| Barbieri, F | 3 |
| Thellung, S | 1 |
| Florio, T | 3 |
| Caviglioli, G | 1 |
| Ding, W | 1 |
| Liao, L | 1 |
| Zhao, J | 2 |
| Tang, Q | 1 |
| Liao, Y | 2 |
| Mohammad, AH | 1 |
| Jatana, S | 1 |
| Ruiz-Barerra, MA | 1 |
| Khalaf, R | 1 |
| Al-Saadi, T | 1 |
| Diaz, RJ | 1 |
| Nan, X | 1 |
| Wang, J | 5 |
| Cheng, H | 1 |
| Yin, Z | 1 |
| Sheng, J | 1 |
| Qiu, B | 1 |
| Lau, CC | 1 |
| Yustein, JT | 1 |
| Zhao, H | 3 |
| Wong, STC | 1 |
| Nguépy Keubo, FR | 1 |
| Mboua, PC | 1 |
| Djifack Tadongfack, T | 1 |
| Fokouong Tchoffo, E | 1 |
| Tasson Tatang, C | 1 |
| Ide Zeuna, J | 1 |
| Noupoue, EM | 1 |
| Tsoplifack, CB | 1 |
| Folefack, GO | 1 |
| Kettani, M | 1 |
| Bandelier, P | 1 |
| Huo, J | 1 |
| Li, H | 4 |
| Yu, D | 1 |
| Arulsamy, N | 1 |
| AlAbbad, S | 1 |
| Sardot, T | 1 |
| Lekashvili, O | 1 |
| Decato, D | 1 |
| Lelj, F | 1 |
| Alexander Ross, JB | 1 |
| Rosenberg, E | 1 |
| Nazir, H | 1 |
| Muthuswamy, N | 1 |
| Louis, C | 1 |
| Jose, S | 1 |
| Prakash, J | 1 |
| Buan, MEM | 1 |
| Flox, C | 1 |
| Chavan, S | 1 |
| Shi, X | 1 |
| Kauranen, P | 1 |
| Kallio, T | 1 |
| Maia, G | 1 |
| Tammeveski, K | 1 |
| Lymperopoulos, N | 1 |
| Carcadea, E | 1 |
| Veziroglu, E | 1 |
| Iranzo, A | 1 |
| M Kannan, A | 1 |
| Arunamata, A | 1 |
| Tacy, TA | 1 |
| Kache, S | 1 |
| Mainwaring, RD | 1 |
| Ma, M | 1 |
| Maeda, K | 1 |
| Punn, R | 1 |
| Noguchi, S | 1 |
| Hahn, S | 3 |
| Iwasa, Y | 3 |
| Ling, J | 2 |
| Voccio, JP | 2 |
| Kim, Y | 3 |
| Song, J | 3 |
| Bascuñán, J | 2 |
| Chu, Y | 1 |
| Tomita, M | 1 |
| Cazorla, M | 1 |
| Herrera, E | 1 |
| Palomeque, E | 1 |
| Saud, N | 1 |
| Hoplock, LB | 1 |
| Lobchuk, MM | 1 |
| Lemoine, J | 1 |
| Henson, MA | 1 |
| Unsihuay, D | 1 |
| Qiu, J | 1 |
| Swaroop, S | 1 |
| Nagornov, KO | 1 |
| Kozhinov, AN | 1 |
| Tsybin, YO | 1 |
| Kuang, S | 1 |
| Laskin, J | 1 |
| Zin, NNINM | 1 |
| Mohamad, MN | 1 |
| Roslan, K | 1 |
| Abdul Wafi, S | 1 |
| Abdul Moin, NI | 1 |
| Alias, A | 1 |
| Zakaria, Y | 1 |
| Abu-Bakar, N | 1 |
| Naveed, A | 1 |
| Jilani, K | 1 |
| Siddique, AB | 1 |
| Akbar, M | 1 |
| Riaz, M | 1 |
| Mushtaq, Z | 1 |
| Sikandar, M | 1 |
| Ilyas, S | 1 |
| Bibi, I | 1 |
| Asghar, A | 1 |
| Rasool, G | 1 |
| Irfan, M | 1 |
| Li, XY | 1 |
| Zhao, S | 1 |
| Fan, XH | 1 |
| Chen, KP | 1 |
| Hua, W | 1 |
| Liu, ZM | 1 |
| Xue, XD | 1 |
| Zhou, B | 1 |
| Zhang, S | 2 |
| Xing, YL | 1 |
| Chen, MA | 1 |
| Sun, Y | 2 |
| Neradilek, MB | 1 |
| Wu, XT | 1 |
| Zhang, D | 2 |
| Huang, W | 1 |
| Cui, Y | 1 |
| Yang, QQ | 1 |
| Li, HW | 1 |
| Zhao, XQ | 1 |
| Hossein Rashidi, B | 1 |
| Tarafdari, A | 1 |
| Ghazimirsaeed, ST | 1 |
| Shahrokh Tehraninezhad, E | 1 |
| Keikha, F | 1 |
| Eslami, B | 1 |
| Ghazimirsaeed, SM | 1 |
| Jafarabadi, M | 1 |
| Silvani, Y | 1 |
| Lovita, AND | 1 |
| Maharani, A | 1 |
| Wiyasa, IWA | 1 |
| Sujuti, H | 1 |
| Ratnawati, R | 1 |
| Raras, TYM | 1 |
| Lemin, AS | 1 |
| Rahman, MM | 1 |
| Pangarah, CA | 1 |
| Kiyu, A | 1 |
| Zeng, C | 2 |
| Du, H | 1 |
| Lin, D | 1 |
| Jalan, D | 1 |
| Rubagumya, F | 1 |
| Hopman, WM | 1 |
| Vanderpuye, V | 1 |
| Lopes, G | 1 |
| Seruga, B | 1 |
| Booth, CM | 1 |
| Berry, S | 1 |
| Hammad, N | 1 |
| Sajo, EA | 1 |
| Okunade, KS | 1 |
| Olorunfemi, G | 1 |
| Rabiu, KA | 1 |
| Anorlu, RI | 1 |
| Xiang, Y | 1 |
| Xu, X | 1 |
| Zhou, L | 2 |
| Dong, X | 1 |
| Tang, S | 1 |
| Gao, XC | 1 |
| Wei, CH | 1 |
| Zhang, RG | 1 |
| Cai, Q | 1 |
| He, Y | 1 |
| Tong, F | 1 |
| Dong, JH | 1 |
| Wu, G | 1 |
| Dong, XR | 1 |
| Tang, X | 1 |
| Tao, F | 1 |
| Xiang, W | 1 |
| Zhao, Y | 2 |
| Jin, L | 1 |
| Tao, H | 1 |
| Lei, Y | 1 |
| Gan, H | 1 |
| Huang, Y | 1 |
| Chen, Y | 4 |
| Chen, L | 3 |
| Shan, A | 1 |
| Wu, M | 2 |
| Ma, Q | 1 |
| Zhang, E | 1 |
| Zhang, J | 3 |
| Li, Y | 6 |
| Xue, F | 1 |
| Deng, L | 1 |
| Liu, L | 2 |
| Yan, Z | 2 |
| Wang, Y | 2 |
| Meng, J | 1 |
| Chen, G | 2 |
| Anastassiadou, M | 1 |
| Bernasconi, G | 1 |
| Brancato, A | 1 |
| Carrasco Cabrera, L | 1 |
| Greco, L | 1 |
| Jarrah, S | 1 |
| Kazocina, A | 1 |
| Leuschner, R | 1 |
| Magrans, JO | 1 |
| Miron, I | 1 |
| Nave, S | 1 |
| Pedersen, R | 1 |
| Reich, H | 1 |
| Rojas, A | 1 |
| Sacchi, A | 1 |
| Santos, M | 1 |
| Theobald, A | 1 |
| Vagenende, B | 1 |
| Verani, A | 1 |
| Du, L | 1 |
| Liu, X | 2 |
| Ren, Y | 1 |
| Li, J | 7 |
| Li, P | 1 |
| Jiao, Q | 1 |
| Meng, P | 1 |
| Wang, F | 2 |
| Wang, YS | 1 |
| Wang, C | 3 |
| Zhou, X | 3 |
| Wang, W | 1 |
| Wang, S | 2 |
| Hou, J | 1 |
| Zhang, A | 1 |
| Lv, B | 1 |
| Gao, C | 1 |
| Pang, D | 1 |
| Lu, K | 1 |
| Ahmad, NH | 1 |
| Wang, L | 1 |
| Zhu, J | 2 |
| Zhang, L | 2 |
| Zhuang, T | 1 |
| Tu, J | 1 |
| Zhao, Z | 1 |
| Qu, Y | 1 |
| Yao, H | 1 |
| Wang, X | 5 |
| Lee, DF | 1 |
| Shen, J | 3 |
| Wen, L | 1 |
| Huang, G | 2 |
| Xie, X | 1 |
| Zhao, Q | 1 |
| Hu, W | 1 |
| Zhang, Y | 4 |
| Wu, X | 1 |
| Lu, J | 2 |
| Li, M | 1 |
| Li, W | 2 |
| Wu, W | 1 |
| Du, F | 1 |
| Ji, H | 1 |
| Yang, X | 2 |
| Xu, Z | 1 |
| Wan, L | 1 |
| Wen, Q | 1 |
| Cho, CH | 1 |
| Zou, C | 1 |
| Xiao, Z | 1 |
| Liao, J | 1 |
| Su, X | 1 |
| Bi, Z | 1 |
| Su, Q | 1 |
| Huang, H | 1 |
| Wei, Y | 2 |
| Gao, Y | 2 |
| Na, KJ | 1 |
| Choi, H | 1 |
| Oh, HR | 1 |
| Kim, YH | 1 |
| Lee, SB | 1 |
| Jung, YJ | 1 |
| Koh, J | 1 |
| Park, S | 1 |
| Lee, HJ | 1 |
| Jeon, YK | 1 |
| Chung, DH | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Metformin and Neo-adjuvant Temozolomide and Hypofractionated Accelerated Limited-margin Radiotherapy Followed by Adjuvant Temozolomide in Patients With Glioblastoma Multiforme (M-HARTT STUDY)[NCT02780024] | Phase 2 | 50 participants (Anticipated) | Interventional | 2015-03-31 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for metformin and Astrocytoma, Grade IV
| Article | Year |
|---|---|
The Potential Therapeutic Impact of Metformin in Glioblastoma Multiforme.
Topics: Animals; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Diabetes Mellitus, Type 2; Glioblast | 2023 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
A Metabolic Inhibitory Cocktail for Grave Cancers: Metformin, Pioglitazone and Lithium Combination in Treatment of Pancreatic Cancer and Glioblastoma Multiforme.
Topics: Brain Neoplasms; Cell Proliferation; Drug Therapy, Combination; Gene Expression Regulation, Neoplast | 2016 |
2 trials available for metformin and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Phase 1 lead-in to a phase 2 factorial study of temozolomide plus memantine, mefloquine, and metformin as postradiation adjuvant therapy for newly diagnosed glioblastoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemotherapy, Adjuvant | 2019 |
35 other studies available for metformin and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Blood exosomes-based targeted delivery of cPLA2 siRNA and metformin to modulate glioblastoma energy metabolism for tailoring personalized therapy.
Topics: Animals; Cell Line, Tumor; Energy Metabolism; Exosomes; Glioblastoma; Humans; Metformin; Phospholipa | 2022 |
Exploring the Mechanism of Adjuvant Treatment of Glioblastoma Using Temozolomide and Metformin.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Diabetes Mellitus, Type 2; DNA | 2022 |
Bacteria-mediated metformin-loaded peptide hydrogel reprograms the tumor immune microenvironment in glioblastoma.
Topics: Bacteria; Brain Neoplasms; Cell Line, Tumor; Glioblastoma; Humans; Hydrogels; Metformin; Peptides; T | 2022 |
Hurdling over the blood-brain barrier with exosome technology.
Topics: Blood-Brain Barrier; Energy Metabolism; Exosomes; Glioblastoma; Humans; Metformin; Phospholipases A2 | 2022 |
Metabolic Heterogeneity of Brain Tumor Cells of Proneural and Mesenchymal Origin.
Topics: Brain; Brain Neoplasms; Cell Line, Tumor; Glioblastoma; Glucose; Humans; Metformin; Neoplastic Stem | 2022 |
Heterogeneity of Amino Acid Profiles of Proneural and Mesenchymal Brain-Tumor Initiating Cells.
Topics: Amino Acids; Brain; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Glioblastoma; Humans; Met | 2023 |
Metformin and simvastatin exert additive antitumour effects in glioblastoma via senescence-state: clinical and translational evidence.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Glioblastoma; Humans; Hydroxymethylglutaryl-CoA Reduc | 2023 |
Development and validation of a GC-MS method for determination of metformin in normal brain and in glioblastoma tissues.
Topics: Animals; Brain; Gas Chromatography-Mass Spectrometry; Glioblastoma; Metformin; Mice; Tissue Distribu | 2023 |
Lower dose of metformin combined with artesunate induced autophagy-dependent apoptosis of glioblastoma by activating ROS-AMPK-mTOR axis.
Topics: AMP-Activated Protein Kinases; Apoptosis; Artesunate; Autophagy; Glioblastoma; Humans; Metformin; Re | 2023 |
Metformin use is associated with longer survival in glioblastoma patients with MGMT gene silencing.
Topics: Brain Neoplasms; Diabetes Mellitus, Type 2; DNA Methylation; DNA Modification Methylases; DNA Repair | 2023 |
Imatinib revives the therapeutic potential of metformin on ewing sarcoma by attenuating tumor hypoxic response and inhibiting convergent signaling pathways.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Bone Neoplasms; Breast Neoplasms | 2020 |
Metformin Increases Exosome Biogenesis and Secretion in U87 MG Human Glioblastoma Cells: A Possible Mechanism of Therapeutic Resistance.
Topics: Exosomes; Glioblastoma; Humans; Hypoglycemic Agents; Metformin | 2021 |
Targeting Cancer Cell Metabolism with Metformin, Dichloroacetate and Memantine in Glioblastoma (GBM).
Topics: Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Dichloroacetic A | 2021 |
The protein kinase LKB1 promotes self-renewal and blocks invasiveness in glioblastoma.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation | 2022 |
Complex I inhibition augments dichloroacetate cytotoxicity through enhancing oxidative stress in VM-M3 glioblastoma cells.
Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Ce | 2017 |
High-Dose Metformin Plus Temozolomide Shows Increased Anti-tumor Effects in Glioblastoma In Vitro and In Vivo Compared with Monotherapy.
Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neopla | 2018 |
Effect of metformin/irinotecan-loaded poly-lactic-co-glycolic acid nanoparticles on glioblastoma: in vitro and in vivo studies.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Proliferation; Cell | 2018 |
Metformin Treatment Inhibits Motility and Invasion of Glioblastoma Cancer Cells.
Topics: Antineoplastic Agents; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Pro | 2018 |
In vitro evaluation of effects of metformin on morphine and methadone tolerance through mammalian target of rapamycin signaling pathway.
Topics: AMP-Activated Protein Kinase Kinases; Analgesics, Opioid; Animals; Cell Line, Tumor; Cyclic AMP; Dru | 2019 |
Unexpectedly low rates of neuropsychiatric adverse effects associated with mefloquine repurposed for the treatment of glioblastoma.
Topics: Glioblastoma; Humans; Mefloquine; Memantine; Metformin; Temozolomide | 2019 |
Reply to Unexpectedly low rates of neuropsychiatric adverse effects associated with mefloquine repurposed for the treatment of glioblastoma.
Topics: Glioblastoma; Humans; Mefloquine; Memantine; Metformin; Temozolomide | 2019 |
Use of metformin and outcome of patients with newly diagnosed glioblastoma: Pooled analysis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Antineoplastic Combin | 2020 |
Discrete mechanisms of mTOR and cell cycle regulation by AMPK agonists independent of AMPK.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Brain Neoplasms; Cell Cycle; Cell Proliferation; Cell | 2014 |
Retrospective analysis of the effects of steroid therapy and antidiabetic medication on survival in diabetic glioblastoma patients.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents; Brain Neoplasms; Cohort Studies; | 2013 |
Metformin repositioning as antitumoral agent: selective antiproliferative effects in human glioblastoma stem cells, via inhibition of CLIC1-mediated ion current.
Topics: Aged; Animals; Antineoplastic Agents; Chloride Channels; CHO Cells; Cricetulus; Drug Repositioning; | 2014 |
Metformin inhibits growth of human glioblastoma cells and enhances therapeutic response.
Topics: Adenylate Kinase; Animals; Apoptosis; Autophagy; Brain Neoplasms; Cell Division; Cell Line, Tumor; D | 2015 |
Metformin influences progression in diabetic glioblastoma patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Blood Glucose; Brain; | 2015 |
Metformin and temozolomide act synergistically to inhibit growth of glioma cells and glioma stem cells in vitro and in vivo.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Differentiation; Cell | 2015 |
Metformin inhibits proliferation and migration of glioblastoma cells independently of TGF-β2.
Topics: Cell Line, Tumor; Cell Movement; Cell Proliferation; Glioblastoma; Humans; Metformin; Models, Biolog | 2016 |
Inhibition of glioblastoma tumorspheres by combined treatment with 2-deoxyglucose and metformin.
Topics: Animals; Antimetabolites; Apoptosis; Brain Neoplasms; Cell Proliferation; Deoxyglucose; Drug Synergi | 2017 |
Metformin treatment reduces temozolomide resistance of glioblastoma cells.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Line, Tumor; Cell Mov | 2016 |
Stattic and metformin inhibit brain tumor initiating cells by reducing STAT3-phosphorylation.
Topics: Adult; Aged; AMP-Activated Protein Kinases; Animals; Antineoplastic Combined Chemotherapy Protocols; | 2017 |
Can the therapeutic effects of temozolomide be potentiated by stimulating AMP-activated protein kinase with olanzepine and metformin?
Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents, Alkylating; Apoptosis; Benzodiazepine | 2011 |
Glioma-initiating cell elimination by metformin activation of FOXO3 via AMPK.
Topics: AMP-Activated Protein Kinases; Animals; Blood-Brain Barrier; Brain Neoplasms; Cell Differentiation; | 2012 |
Metformin selectively affects human glioblastoma tumor-initiating cell viability: A role for metformin-induced inhibition of Akt.
Topics: AC133 Antigen; Aged; Animals; Antigens, CD; Antineoplastic Agents; Cell Differentiation; Cell Surviv | 2013 |