metformin has been researched along with Asthma, Bronchial in 27 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin is associated with improved respiratory outcomes in asthma; however, metformin in COPD and asthma-COPD overlap (ACO) remains unexplored." | 9.41 | Metformin use and respiratory outcomes in asthma-COPD overlap. ( Bon, J; Fawzy, A; Hansel, NN; Kinney, GL; McCormack, MC; Neupane, M; Putcha, N; Tejwani, V; Wise, RA; Wu, TD, 2021) |
| "We searched the PubMed, Embase, and CENTRAL databases for articles published prior to April 2020 to find observational studies of individuals with concurrent asthma and diabetes that compared the risk of asthma exacerbation between metformin users and nonusers." | 9.05 | Association of Metformin Use with Asthma Exacerbation in Patients with Concurrent Asthma and Diabetes: A Systematic Review and Meta-Analysis of Observational Studies. ( Chai, Y; Changfu, Y; Gao, J; Guan, L; Haiyang, Y; Huaiquan, L; Qingxue, W; Wen, L; Yunzhi, C; Zhong, Q; Zhong, W, 2020) |
| "It was suggested that metformin could impede the MC activation and airway resistance in the concomitant diabetic and asthmatic rats." | 8.31 | Metformin regulates the effects of IR and IGF-1R methylation on mast cell activation and airway reactivity in diabetic rats with asthma through miR-152-3p/DNMT1 axis. ( Feng, H; Fu, D; He, L; Huang, Y; Li, A; Li, J; Liu, Y; Zhao, H, 2023) |
| "We conducted this study to compare the risks of asthma development and exacerbation between metformin users and nonusers." | 8.12 | Metformin and the Development of Asthma in Patients with Type 2 Diabetes. ( Hsu, CC; Hwu, CM; Pan, WL; Shih, YH; Wei, JC; Yen, FS, 2022) |
| " Metformin has potential effects on improving asthma airway inflammation." | 8.02 | Metformin alleviates allergic airway inflammation and increases Treg cells in obese asthma. ( Chen, M; Guo, Y; Hong, L; Jiang, S; Liu, S; Shi, J; Wang, Q; Yuan, X, 2021) |
| "To determine the association between metformin use and asthma exacerbations among patients with diabetes." | 8.02 | Metformin Use and Risk of Asthma Exacerbation Among Asthma Patients with Glycemic Dysfunction. ( Akenroye, A; Fawzy, A; Hansel, NN; Keet, C; McCormack, MC; Wu, TD, 2021) |
| "The risk of asthma-related outcomes was lower for metformin users than non-users." | 7.83 | Metformin use and asthma outcomes among patients with concurrent asthma and diabetes. ( Erickson, SR; Li, CY; Wu, CH, 2016) |
| " The AMP-activated protein kinase (AMPK) activator metformin reverses obesity-associated insulin resistance (IR) and inhibits different types of inflammatory responses." | 7.79 | Metformin attenuates the exacerbation of the allergic eosinophilic inflammation in high fat-diet-induced obesity in mice. ( André, DM; Anhê, GF; Antunes, E; Bordin, S; Calixto, MC; Ferreira, D; Landgraf, RG; Leiria, LO; Lellis-Santos, C; Lintomen, L, 2013) |
| "Metformin is associated with improved respiratory outcomes in asthma; however, metformin in COPD and asthma-COPD overlap (ACO) remains unexplored." | 5.41 | Metformin use and respiratory outcomes in asthma-COPD overlap. ( Bon, J; Fawzy, A; Hansel, NN; Kinney, GL; McCormack, MC; Neupane, M; Putcha, N; Tejwani, V; Wise, RA; Wu, TD, 2021) |
| "An 8-year clinical follow-up study including self-reported asthma diagnoses and spirometry of women with PCOS randomized to metformin or placebo during pregnancy in the original studies (the Pilot and the PregMet-study), compared with matched controls from a population-based cohort study (The HUNT Study)." | 5.34 | Impaired Respiratory Function in Women With PCOS Compared With Matched Controls From a Population-Based Study. ( Andersen, M; Henriksen, AH; Salvesen, Ø; Underdal, MO; Vanky, E, 2020) |
| "We searched the PubMed, Embase, and CENTRAL databases for articles published prior to April 2020 to find observational studies of individuals with concurrent asthma and diabetes that compared the risk of asthma exacerbation between metformin users and nonusers." | 5.05 | Association of Metformin Use with Asthma Exacerbation in Patients with Concurrent Asthma and Diabetes: A Systematic Review and Meta-Analysis of Observational Studies. ( Chai, Y; Changfu, Y; Gao, J; Guan, L; Haiyang, Y; Huaiquan, L; Qingxue, W; Wen, L; Yunzhi, C; Zhong, Q; Zhong, W, 2020) |
| "It was suggested that metformin could impede the MC activation and airway resistance in the concomitant diabetic and asthmatic rats." | 4.31 | Metformin regulates the effects of IR and IGF-1R methylation on mast cell activation and airway reactivity in diabetic rats with asthma through miR-152-3p/DNMT1 axis. ( Feng, H; Fu, D; He, L; Huang, Y; Li, A; Li, J; Liu, Y; Zhao, H, 2023) |
| "We conducted this study to compare the risks of asthma development and exacerbation between metformin users and nonusers." | 4.12 | Metformin and the Development of Asthma in Patients with Type 2 Diabetes. ( Hsu, CC; Hwu, CM; Pan, WL; Shih, YH; Wei, JC; Yen, FS, 2022) |
| " Metformin has potential effects on improving asthma airway inflammation." | 4.02 | Metformin alleviates allergic airway inflammation and increases Treg cells in obese asthma. ( Chen, M; Guo, Y; Hong, L; Jiang, S; Liu, S; Shi, J; Wang, Q; Yuan, X, 2021) |
| "To determine the association between metformin use and asthma exacerbations among patients with diabetes." | 4.02 | Metformin Use and Risk of Asthma Exacerbation Among Asthma Patients with Glycemic Dysfunction. ( Akenroye, A; Fawzy, A; Hansel, NN; Keet, C; McCormack, MC; Wu, TD, 2021) |
| "The risk of asthma-related outcomes was lower for metformin users than non-users." | 3.83 | Metformin use and asthma outcomes among patients with concurrent asthma and diabetes. ( Erickson, SR; Li, CY; Wu, CH, 2016) |
| " The AMP-activated protein kinase (AMPK) activator metformin reverses obesity-associated insulin resistance (IR) and inhibits different types of inflammatory responses." | 3.79 | Metformin attenuates the exacerbation of the allergic eosinophilic inflammation in high fat-diet-induced obesity in mice. ( André, DM; Anhê, GF; Antunes, E; Bordin, S; Calixto, MC; Ferreira, D; Landgraf, RG; Leiria, LO; Lellis-Santos, C; Lintomen, L, 2013) |
| " These mice also have enhanced inflammatory responses to ozone, a common air pollutant that exacerbates asthma." | 3.74 | No effect of metformin on the innate airway hyperresponsiveness and increased responses to ozone observed in obese mice. ( Shore, SA; Williams, ES; Zhu, M, 2008) |
| "Metformin users were less likely to be involved in accident-related events (adjusted hazard ratio [aHR] 0." | 1.51 | Evaluation of Healthy User Effects With Metformin and Other Oral Antihyperglycemia Medication Users in Adult Patients With Type 2 Diabetes. ( Eskin, M; Eurich, DT; Simpson, SH, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.70) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (3.70) | 29.6817 |
| 2010's | 16 (59.26) | 24.3611 |
| 2020's | 9 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Calco, GN | 1 |
| Proskocil, BJ | 1 |
| Jacoby, DB | 1 |
| Fryer, AD | 1 |
| Nie, Z | 1 |
| Yen, FS | 1 |
| Hsu, CC | 1 |
| Shih, YH | 1 |
| Pan, WL | 1 |
| Wei, JC | 1 |
| Hwu, CM | 1 |
| Fu, D | 1 |
| Zhao, H | 1 |
| Huang, Y | 1 |
| Li, J | 1 |
| Feng, H | 1 |
| Li, A | 1 |
| Liu, Y | 1 |
| He, L | 1 |
| Wu, TD | 3 |
| Keet, CA | 1 |
| Fawzy, A | 3 |
| Segal, JB | 1 |
| Brigham, EP | 1 |
| McCormack, MC | 3 |
| Underdal, MO | 1 |
| Salvesen, Ø | 1 |
| Henriksen, AH | 1 |
| Andersen, M | 1 |
| Vanky, E | 1 |
| Rastogi, D | 1 |
| Wen, L | 1 |
| Zhong, W | 1 |
| Chai, Y | 1 |
| Zhong, Q | 1 |
| Gao, J | 1 |
| Guan, L | 1 |
| Huaiquan, L | 1 |
| Haiyang, Y | 1 |
| Qingxue, W | 1 |
| Changfu, Y | 1 |
| Yunzhi, C | 1 |
| Guo, Y | 1 |
| Shi, J | 1 |
| Wang, Q | 1 |
| Hong, L | 1 |
| Chen, M | 1 |
| Liu, S | 1 |
| Yuan, X | 1 |
| Jiang, S | 1 |
| Kinney, GL | 1 |
| Bon, J | 1 |
| Neupane, M | 1 |
| Tejwani, V | 1 |
| Hansel, NN | 2 |
| Wise, RA | 1 |
| Putcha, N | 1 |
| Ma, B | 1 |
| Athari, SS | 1 |
| Mehrabi Nasab, E | 1 |
| Zhao, L | 1 |
| Akenroye, A | 1 |
| Keet, C | 1 |
| Srivastava, D | 1 |
| Fatima, Z | 1 |
| Kaur, CD | 1 |
| Eskin, M | 1 |
| Simpson, SH | 1 |
| Eurich, DT | 1 |
| Rayner, LH | 1 |
| Mcgovern, A | 1 |
| Sherlock, J | 1 |
| Gatenby, P | 1 |
| Correa, A | 1 |
| Creagh-Brown, B | 1 |
| deLusignan, S | 1 |
| Calixto, MC | 1 |
| Lintomen, L | 1 |
| André, DM | 1 |
| Leiria, LO | 1 |
| Ferreira, D | 1 |
| Lellis-Santos, C | 1 |
| Anhê, GF | 1 |
| Bordin, S | 1 |
| Landgraf, RG | 1 |
| Antunes, E | 1 |
| Linderholm, AL | 1 |
| Bratt, JM | 1 |
| Schuster, GU | 1 |
| Zeki, AA | 1 |
| Kenyon, NJ | 1 |
| Agrawal, A | 1 |
| He, LR | 1 |
| Qiao, W | 1 |
| Liao, ZX | 1 |
| Komaki, R | 1 |
| Ho, L | 1 |
| Hofstetter, WL | 1 |
| Lin, SH | 1 |
| Li, CY | 3 |
| Erickson, SR | 2 |
| Wu, CH | 2 |
| Forno, E | 1 |
| Veeranki, SP | 1 |
| Chen, CZ | 1 |
| Hsu, CH | 1 |
| Hsiue, TR | 1 |
| Shore, SA | 2 |
| Williams, ES | 1 |
| Zhu, M | 2 |
| Flynt, L | 1 |
| Ghosh, S | 1 |
| Mellema, M | 1 |
| Banerjee, A | 1 |
| Williams, E | 1 |
| Panettieri, RA | 1 |
| Park, CS | 1 |
| Bang, BR | 1 |
| Kwon, HS | 1 |
| Moon, KA | 1 |
| Kim, TB | 1 |
| Lee, KY | 1 |
| Moon, HB | 1 |
| Cho, YS | 1 |
| Laursen, B | 1 |
| Gormsen, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Metformin Treatment of Pregnant Women With Polycystic Ovary Syndrome (PCOS)[NCT00159536] | Phase 3 | 257 participants (Actual) | Interventional | 2005-02-28 | Completed | ||
| Metformin Treatment of Pregnant Women With Polycystic Ovary Syndrome: a Pilot Study[NCT03259919] | Phase 2 | 40 participants (Actual) | Interventional | 2000-10-31 | Completed | ||
| Genetic Epidemiology of Chronic Obstructive Pulmonary Disease[NCT00608764] | 10,718 participants (Actual) | Observational | 2007-11-30 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for metformin and Asthma, Bronchial
| Article | Year |
|---|---|
Association of Metformin Use with Asthma Exacerbation in Patients with Concurrent Asthma and Diabetes: A Systematic Review and Meta-Analysis of Observational Studies.
Topics: Asthma; Diabetes Mellitus, Type 2; Disease Progression; Humans; Metformin; Observational Studies as | 2020 |
Multicomponent Pharmaceutical Cocrystals: A Novel Approach for Combination Therapy.
Topics: Asthma; Chemistry, Pharmaceutical; Crystallization; Diabetes Mellitus; Drug Therapy, Combination; Fl | 2018 |
Novel therapeutic strategies for adult obese asthmatics.
Topics: Adenylate Kinase; Adult; Airway Remodeling; Arginine; Asthma; Dietary Supplements; Humans; Hydroxyme | 2014 |
2 trials available for metformin and Asthma, Bronchial
| Article | Year |
|---|---|
Impaired Respiratory Function in Women With PCOS Compared With Matched Controls From a Population-Based Study.
Topics: Adult; Asthma; Case-Control Studies; Cohort Studies; Female; Follow-Up Studies; Humans; Metformin; P | 2020 |
Impaired Respiratory Function in Women With PCOS Compared With Matched Controls From a Population-Based Study.
Topics: Adult; Asthma; Case-Control Studies; Cohort Studies; Female; Follow-Up Studies; Humans; Metformin; P | 2020 |
Impaired Respiratory Function in Women With PCOS Compared With Matched Controls From a Population-Based Study.
Topics: Adult; Asthma; Case-Control Studies; Cohort Studies; Female; Follow-Up Studies; Humans; Metformin; P | 2020 |
Impaired Respiratory Function in Women With PCOS Compared With Matched Controls From a Population-Based Study.
Topics: Adult; Asthma; Case-Control Studies; Cohort Studies; Female; Follow-Up Studies; Humans; Metformin; P | 2020 |
Metformin use and respiratory outcomes in asthma-COPD overlap.
Topics: Adult; Aged; Asthma; Cohort Studies; Comorbidity; Cross-Sectional Studies; Female; Follow-Up Studies | 2021 |
22 other studies available for metformin and Asthma, Bronchial
| Article | Year |
|---|---|
Metformin prevents airway hyperreactivity in rats with dietary obesity.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchoconstriction; Bronchoconstrictor Agents; Diet, Hi | 2021 |
Metformin and the Development of Asthma in Patients with Type 2 Diabetes.
Topics: Asthma; Diabetes Mellitus, Type 2; Hospitalization; Humans; Hypoglycemic Agents; Incidence; Metformi | 2022 |
Metformin regulates the effects of IR and IGF-1R methylation on mast cell activation and airway reactivity in diabetic rats with asthma through miR-152-3p/DNMT1 axis.
Topics: Animals; Asthma; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Mast Cells; Metformin; | 2023 |
Association of Metformin Initiation and Risk of Asthma Exacerbation. A Claims-based Cohort Study.
Topics: Adult; Asthma; Databases, Factual; Diabetes Mellitus; Disease Progression; Emergency Service, Hospit | 2019 |
Evidence Builds for a Role of Metformin in Asthma Management.
Topics: Asthma; Cohort Studies; Diabetes Mellitus, Type 2; Humans; Metformin; Monitoring, Physiologic | 2019 |
Metformin alleviates allergic airway inflammation and increases Treg cells in obese asthma.
Topics: Animals; Anti-Inflammatory Agents; Asthma; Body Weight; Bronchoalveolar Lavage Fluid; CD4 Lymphocyte | 2021 |
PI3K/AKT/mTOR and TLR4/MyD88/NF-κB Signaling Inhibitors Attenuate Pathological Mechanisms of Allergic Asthma.
Topics: Animals; Anti-Asthmatic Agents; Asthma; Chromones; Female; Metformin; Mice; Mice, Inbred BALB C; Mor | 2021 |
Metformin Use and Risk of Asthma Exacerbation Among Asthma Patients with Glycemic Dysfunction.
Topics: Adult; Asthma; Diabetes Mellitus, Type 2; Glycated Hemoglobin; Hospitalization; Humans; Metformin; R | 2021 |
Evaluation of Healthy User Effects With Metformin and Other Oral Antihyperglycemia Medication Users in Adult Patients With Type 2 Diabetes.
Topics: Administration, Oral; Adult; Asthma; Biomarkers; Blood Glucose; Diabetes Mellitus, Type 2; Drug Ther | 2019 |
The impact of therapy on the risk of asthma in type 2 diabetes.
Topics: Aged; Asthma; Case-Control Studies; Diabetes Mellitus, Type 2; England; Humans; Hypoglycemic Agents; | 2019 |
Metformin attenuates the exacerbation of the allergic eosinophilic inflammation in high fat-diet-induced obesity in mice.
Topics: AMP-Activated Protein Kinases; Animals; Asthma; Blotting, Western; Bronchoalveolar Lavage Fluid; Die | 2013 |
Urban, obese, allergic, and breathless: the shape of things to come?
Topics: Adult; Animals; Anti-Inflammatory Agents; Asthma; Child; Dyspnea; Feeding Behavior; Humans; Insulin | 2014 |
Impact of comorbidities and use of common medications on cancer and non-cancer specific survival in esophageal carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Angiotensin Receptor Antagonists; Anti-Inflammatory Agents, Non-Ster | 2015 |
Metformin use and asthma outcomes among patients with concurrent asthma and diabetes.
Topics: Adult; Aged; Asthma; Cohort Studies; Diabetes Mellitus, Type 2; Female; Hospitalization; Humans; Log | 2016 |
Asthma and diabetes: Does treatment with metformin improve asthma?
Topics: Asthma; Blood Glucose; Diabetes Mellitus, Type 2; Humans; Metformin | 2016 |
Metformin use and asthma: Further investigations.
Topics: Asthma; Humans; Metformin | 2017 |
Metformin use and asthma: Further investigations - Reply.
Topics: Asthma; Diabetes Mellitus, Type 2; Humans; Metformin | 2017 |
Insulin use increases risk of asthma but metformin use reduces the risk in patients with diabetes in a Taiwanese population cohort.
Topics: Adult; Age Distribution; Aged; Aged, 80 and over; Asthma; Case-Control Studies; Diabetes Mellitus; F | 2017 |
No effect of metformin on the innate airway hyperresponsiveness and increased responses to ozone observed in obese mice.
Topics: Administration, Oral; Animals; Asthma; Blood Glucose; Body Weight; Bronchial Hyperreactivity; Bronch | 2008 |
Anti-inflammatory effects of thiazolidinediones in human airway smooth muscle cells.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Anilides; Anti-Inflammatory Agents; Antim | 2011 |
Metformin reduces airway inflammation and remodeling via activation of AMP-activated protein kinase.
Topics: AMP-Activated Protein Kinases; Animals; Asthma; Base Sequence; Blotting, Western; Disease Models, An | 2012 |
Pharmacological enhancement and short-term stimulation of blood fibrinolytic activity.
Topics: Adolescent; Adult; Aged; Aminocaproates; Anticholesteremic Agents; Arteriosclerosis; Arthritis, Rheu | 1969 |