metformin has been researched along with Aortic Valve Stenosis in 3 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Aortic Valve Stenosis: A pathological constriction that can occur above (supravalvular stenosis), below (subvalvular stenosis), or at the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin treatment ameliorated AVICs calcification and apoptosis by activating the PI3K/AKT signaling pathway." | 1.62 | Metformin alleviates the calcification of aortic valve interstitial cells through activating the PI3K/AKT pathway in an AMPK dependent way. ( En, Q; Wei, W; Xu, W; Yuetang, W; Zeping, H, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (66.67) | 2.80 |
| Authors | Studies |
|---|---|
| En, Q | 1 |
| Zeping, H | 1 |
| Yuetang, W | 1 |
| Xu, W | 1 |
| Wei, W | 1 |
| Phadwal, K | 1 |
| Tan, X | 1 |
| Koo, E | 1 |
| Zhu, D | 1 |
| MacRae, VE | 1 |
| Tewari, P | 1 |
| Nath, SS | 1 |
| Mazumdar, G | 1 |
3 other studies available for metformin and Aortic Valve Stenosis
| Article | Year |
|---|---|
Metformin alleviates the calcification of aortic valve interstitial cells through activating the PI3K/AKT pathway in an AMPK dependent way.
Topics: AMP-Activated Protein Kinases; Aortic Valve; Aortic Valve Stenosis; Calcinosis; Cells, Cultured; Hum | 2021 |
Metformin ameliorates valve interstitial cell calcification by promoting autophagic flux.
Topics: Animals; Aortic Valve Stenosis; Autophagy; Cells, Cultured; Core Binding Factor Alpha 1 Subunit; Met | 2023 |
Increased prothrombin time and lactic acidosis: rofecoxib drug interaction with acenocoumarin and metformin.
Topics: Acenocoumarol; Acidosis, Lactic; Anticoagulants; Aortic Valve Stenosis; Cyclooxygenase 2 Inhibitors; | 2007 |