metformin has been researched along with Aortic Diseases in 5 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Aortic Diseases: Pathological processes involving any part of the AORTA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin activates a conserved AMPK-ATF1-M2-like pathway in mouse and human macrophages, and results in highly suppressed atherogenesis in hyperlipidaemic mice via haematopoietic AMPK." | 8.02 | Metformin directly suppresses atherosclerosis in normoglycaemic mice via haematopoietic adenosine monophosphate-activated protein kinase. ( Boyle, JJ; Carling, D; Cave, L; Haskard, DO; Hyde, G; Mason, JC; Moestrup, SK; Seneviratne, A, 2021) |
| "Using ApoE−/− C57BL/6J mice, we found that metformin attenuates atherosclerosis and vascular senescence in mice fed a high‐fat diet and prevents the upregulation of angiotensin II type 1 receptor by a high‐fat diet in the aortas of mice." | 7.80 | Metformin beyond diabetes: pleiotropic benefits of metformin in attenuation of atherosclerosis. ( Alexander, RW; Fei, B; Forouzandeh, F; Hilenski, L; Patrushev, N; Salazar, G; Xiong, S, 2014) |
| "Metformin activates a conserved AMPK-ATF1-M2-like pathway in mouse and human macrophages, and results in highly suppressed atherogenesis in hyperlipidaemic mice via haematopoietic AMPK." | 4.02 | Metformin directly suppresses atherosclerosis in normoglycaemic mice via haematopoietic adenosine monophosphate-activated protein kinase. ( Boyle, JJ; Carling, D; Cave, L; Haskard, DO; Hyde, G; Mason, JC; Moestrup, SK; Seneviratne, A, 2021) |
| "Using ApoE−/− C57BL/6J mice, we found that metformin attenuates atherosclerosis and vascular senescence in mice fed a high‐fat diet and prevents the upregulation of angiotensin II type 1 receptor by a high‐fat diet in the aortas of mice." | 3.80 | Metformin beyond diabetes: pleiotropic benefits of metformin in attenuation of atherosclerosis. ( Alexander, RW; Fei, B; Forouzandeh, F; Hilenski, L; Patrushev, N; Salazar, G; Xiong, S, 2014) |
| "Metformin is a hypoglycaemic agent widely used in the management of type 2 diabetes." | 2.42 | Antiatherogenic properties of metformin: the experimental evidence. ( Mamputu, JC; Renier, G; Wiernsperger, NF, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Seneviratne, A | 1 |
| Cave, L | 1 |
| Hyde, G | 1 |
| Moestrup, SK | 1 |
| Carling, D | 1 |
| Mason, JC | 1 |
| Haskard, DO | 1 |
| Boyle, JJ | 1 |
| Forouzandeh, F | 1 |
| Salazar, G | 1 |
| Patrushev, N | 1 |
| Xiong, S | 1 |
| Hilenski, L | 1 |
| Fei, B | 1 |
| Alexander, RW | 1 |
| Wang, J | 1 |
| Ma, A | 1 |
| Zhao, M | 1 |
| Zhu, H | 1 |
| Mamputu, JC | 1 |
| Wiernsperger, NF | 1 |
| Renier, G | 1 |
| Marquié, G | 1 |
1 review available for metformin and Aortic Diseases
| Article | Year |
|---|---|
Antiatherogenic properties of metformin: the experimental evidence.
Topics: Animals; Aortic Diseases; Arteries; Arteriosclerosis; Diabetes Mellitus, Type 2; Disease Models, Ani | 2003 |
4 other studies available for metformin and Aortic Diseases
| Article | Year |
|---|---|
Metformin directly suppresses atherosclerosis in normoglycaemic mice via haematopoietic adenosine monophosphate-activated protein kinase.
Topics: Activating Transcription Factor 1; AMP-Activated Protein Kinases; Animals; Aorta; Aortic Diseases; A | 2021 |
Metformin beyond diabetes: pleiotropic benefits of metformin in attenuation of atherosclerosis.
Topics: Animals; Aorta; Aortic Diseases; Apolipoproteins E; Atherosclerosis; Blood Glucose; Cardiovascular A | 2014 |
AMPK activation reduces the number of atheromata macrophages in ApoE deficient mice.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Antigens, Ly; Aorta; Aortic Dise | 2017 |
Metformin action on lipid metabolism in lesions of experimental aortic atherosclerosis of rabbits.
Topics: Animals; Anticholesteremic Agents; Aorta; Aortic Diseases; Arteriosclerosis; Cholesterol; Depression | 1983 |