metformin has been researched along with Anxiety in 20 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Anxiety: Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study aimed at investigating the therapeutic effect and mechanism of pioglitazone metformin complex preparation (PM) in polycystic ovary syndrome (PCOS) comorbid psychological distress." | 9.34 | Pioglitazone Metformin Complex Improves Polycystic Ovary Syndrome Comorbid Psychological Distress via Inhibiting NLRP3 Inflammasome Activation: A Prospective Clinical Study. ( Guo, QJ; Hu, YY; Huang, Q; Huo, CL; Shan, J; Song, JY; Wang, CQ; Xu, YF; Yu, CQ; Zhou, H, 2020) |
| "Data on comparison of myo-inositol and metformin on mental health parameters and biomarkers of oxidative stress in subjects with polycystic ovary syndrome (PCOS) are scarce." | 9.27 | Comparison of myo-inositol and metformin on mental health parameters and biomarkers of oxidative stress in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. ( Afshar Ebrahimi, F; Asemi, Z; Bahmani, F; Foroozanfard, F; Jamilian, H; Jamilian, M, 2018) |
| "We examine the effects of metformin on insulin resistance (IR) and mood including in adolescent and adult women with polycystic ovary syndrome (PCOS)." | 7.91 | A pilot trial of metformin for insulin resistance and mood disturbances in adolescent and adult women with polycystic ovary syndrome. ( Aghamohammadzadeh, N; Erensoy, H; Ghafarzadeh, S; Nader, ND; Niafar, M, 2019) |
| "According to the data obtained, methamphetamine caused significant depression, anxiety, motor activity disturbances and cognition impairment in experimental animals." | 7.91 | Protective role of metformin against methamphetamine induced anxiety, depression, cognition impairment and neurodegeneration in rat: The role of CREB/BDNF and Akt/GSK3 signaling pathways. ( Karami, L; Kermanshahi, S; Keshavarzi, S; Motaghinejad, M; Motevalian, M; Sadr, S, 2019) |
| " Metformin, widely known as an antidiabetic drug, has been found to enhance spatial memory formation and improve anxiety-like behaviors in rodents." | 7.91 | Metformin reverses the schizophrenia-like behaviors induced by MK-801 in rats. ( Li, X; Liu, ZQ; Luo, C; Mao, XY; Wang, X; Yin, JY; Zhang, W; Zhou, HH, 2019) |
| "Metformin treatment significantly decreased depressive behaviour and malondialdehyde content in the prefrontal cortex." | 5.62 | Protective effect of metformin against ovariectomy induced depressive- and anxiety-like behaviours in rats: role of oxidative stress. ( Erdem, S; Ergenc, M; Ozacmak, VH; Sayan Özaçmak, H; Turan, I, 2021) |
| "Metformin was pretreated for 2 weeks and CC administrated half an hour before global cerebral ischemia." | 5.42 | Metformin improves anxiety-like behaviors through AMPK-dependent regulation of autophagy following transient forebrain ischemia. ( Ashabi, G; Badavi, M; Farbood, Y; Khalaj, L; Khodagholi, F; Sarkaki, A, 2015) |
| "This study aimed at investigating the therapeutic effect and mechanism of pioglitazone metformin complex preparation (PM) in polycystic ovary syndrome (PCOS) comorbid psychological distress." | 5.34 | Pioglitazone Metformin Complex Improves Polycystic Ovary Syndrome Comorbid Psychological Distress via Inhibiting NLRP3 Inflammasome Activation: A Prospective Clinical Study. ( Guo, QJ; Hu, YY; Huang, Q; Huo, CL; Shan, J; Song, JY; Wang, CQ; Xu, YF; Yu, CQ; Zhou, H, 2020) |
| "Data on comparison of myo-inositol and metformin on mental health parameters and biomarkers of oxidative stress in subjects with polycystic ovary syndrome (PCOS) are scarce." | 5.27 | Comparison of myo-inositol and metformin on mental health parameters and biomarkers of oxidative stress in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. ( Afshar Ebrahimi, F; Asemi, Z; Bahmani, F; Foroozanfard, F; Jamilian, H; Jamilian, M, 2018) |
| "We examine the effects of metformin on insulin resistance (IR) and mood including in adolescent and adult women with polycystic ovary syndrome (PCOS)." | 3.91 | A pilot trial of metformin for insulin resistance and mood disturbances in adolescent and adult women with polycystic ovary syndrome. ( Aghamohammadzadeh, N; Erensoy, H; Ghafarzadeh, S; Nader, ND; Niafar, M, 2019) |
| "We examined the effects of metformin on anxiety-like behaviour of rats in open field test and elevated plus maze test." | 3.91 | Metformin produces anxiolytic-like effects in rats by facilitating GABA ( Chen, HS; Chen, JG; Fan, J; Huang, JG; Li, D; Wang, F; Xu, JF; Zhu, WW, 2019) |
| "According to the data obtained, methamphetamine caused significant depression, anxiety, motor activity disturbances and cognition impairment in experimental animals." | 3.91 | Protective role of metformin against methamphetamine induced anxiety, depression, cognition impairment and neurodegeneration in rat: The role of CREB/BDNF and Akt/GSK3 signaling pathways. ( Karami, L; Kermanshahi, S; Keshavarzi, S; Motaghinejad, M; Motevalian, M; Sadr, S, 2019) |
| " Metformin, widely known as an antidiabetic drug, has been found to enhance spatial memory formation and improve anxiety-like behaviors in rodents." | 3.91 | Metformin reverses the schizophrenia-like behaviors induced by MK-801 in rats. ( Li, X; Liu, ZQ; Luo, C; Mao, XY; Wang, X; Yin, JY; Zhang, W; Zhou, HH, 2019) |
| "Metformin treatment significantly decreased depressive behaviour and malondialdehyde content in the prefrontal cortex." | 1.62 | Protective effect of metformin against ovariectomy induced depressive- and anxiety-like behaviours in rats: role of oxidative stress. ( Erdem, S; Ergenc, M; Ozacmak, VH; Sayan Özaçmak, H; Turan, I, 2021) |
| "Metformin was pretreated for 2 weeks and CC administrated half an hour before global cerebral ischemia." | 1.42 | Metformin improves anxiety-like behaviors through AMPK-dependent regulation of autophagy following transient forebrain ischemia. ( Ashabi, G; Badavi, M; Farbood, Y; Khalaj, L; Khodagholi, F; Sarkaki, A, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (10.00) | 29.6817 |
| 2010's | 12 (60.00) | 24.3611 |
| 2020's | 6 (30.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, J | 1 |
| Zhang, Z | 1 |
| Xie, Z | 1 |
| Bai, L | 1 |
| Xiong, P | 1 |
| Chen, F | 1 |
| Zhu, T | 1 |
| Peng, Q | 1 |
| Wu, H | 1 |
| Zhou, Y | 1 |
| Ma, Y | 1 |
| Zhang, Y | 1 |
| Chen, M | 1 |
| Gao, J | 1 |
| Tian, W | 1 |
| Shi, K | 1 |
| Du, Y | 1 |
| Duan, Y | 1 |
| Wang, H | 1 |
| Xu, Y | 2 |
| Kuang, YQ | 1 |
| Zhu, M | 1 |
| Yu, J | 1 |
| Wang, K | 1 |
| Gao, Z | 1 |
| Lv, H | 1 |
| Wang, Y | 1 |
| Xie, Y | 1 |
| Guan, M | 1 |
| Guo, QJ | 1 |
| Shan, J | 1 |
| Xu, YF | 1 |
| Hu, YY | 1 |
| Huo, CL | 1 |
| Song, JY | 1 |
| Wang, CQ | 1 |
| Zhou, H | 1 |
| Yu, CQ | 1 |
| Huang, Q | 1 |
| Bonea, M | 1 |
| Filip, GA | 1 |
| Toma, VA | 1 |
| Baldea, I | 1 |
| Berghian, AS | 1 |
| Decea, N | 1 |
| Olteanu, D | 1 |
| Moldovan, R | 1 |
| Crivii, C | 1 |
| Vinași, RC | 1 |
| Micluția, IV | 1 |
| Nesci, V | 1 |
| Russo, E | 1 |
| Arcidiacono, B | 1 |
| Citraro, R | 1 |
| Tallarico, M | 1 |
| Constanti, A | 1 |
| Brunetti, A | 1 |
| De Sarro, G | 1 |
| Leo, A | 1 |
| Turan, I | 1 |
| Sayan Özaçmak, H | 1 |
| Erdem, S | 1 |
| Ergenc, M | 1 |
| Ozacmak, VH | 1 |
| Jamilian, H | 1 |
| Jamilian, M | 1 |
| Foroozanfard, F | 1 |
| Afshar Ebrahimi, F | 1 |
| Bahmani, F | 1 |
| Asemi, Z | 1 |
| Erensoy, H | 1 |
| Niafar, M | 1 |
| Ghafarzadeh, S | 1 |
| Aghamohammadzadeh, N | 1 |
| Nader, ND | 1 |
| Fan, J | 1 |
| Li, D | 1 |
| Chen, HS | 1 |
| Huang, JG | 1 |
| Xu, JF | 1 |
| Zhu, WW | 1 |
| Chen, JG | 1 |
| Wang, F | 1 |
| Keshavarzi, S | 1 |
| Kermanshahi, S | 1 |
| Karami, L | 1 |
| Motaghinejad, M | 1 |
| Motevalian, M | 1 |
| Sadr, S | 1 |
| Wang, X | 1 |
| Luo, C | 1 |
| Mao, XY | 1 |
| Li, X | 1 |
| Yin, JY | 1 |
| Zhang, W | 1 |
| Zhou, HH | 1 |
| Liu, ZQ | 1 |
| Zemdegs, J | 1 |
| Martin, H | 1 |
| Pintana, H | 1 |
| Bullich, S | 1 |
| Manta, S | 1 |
| Marqués, MA | 1 |
| Moro, C | 1 |
| Layé, S | 1 |
| Ducrocq, F | 1 |
| Chattipakorn, N | 1 |
| Chattipakorn, SC | 1 |
| Rampon, C | 1 |
| Pénicaud, L | 1 |
| Fioramonti, X | 1 |
| Guiard, BP | 1 |
| Zakeri, M | 1 |
| Fatemi, I | 1 |
| Kaeidi, A | 1 |
| Zakeri, MA | 1 |
| Hakimizadeh, E | 1 |
| Hassanipour, M | 1 |
| Rahmani, M | 1 |
| Hassanshahi, J | 1 |
| Ayoobi, F | 1 |
| Allahtavakoli, M | 1 |
| Lennox, R | 1 |
| Porter, DW | 1 |
| Flatt, PR | 1 |
| Holscher, C | 1 |
| Irwin, N | 1 |
| Gault, VA | 1 |
| Sarkaki, A | 1 |
| Farbood, Y | 1 |
| Badavi, M | 1 |
| Khalaj, L | 1 |
| Khodagholi, F | 1 |
| Ashabi, G | 1 |
| Ge, XH | 1 |
| Zhu, GJ | 1 |
| Geng, DQ | 1 |
| Zhang, HZ | 1 |
| He, JM | 1 |
| Guo, AZ | 1 |
| Ma, LL | 1 |
| Yu, DH | 1 |
| Aswar, U | 1 |
| Chepurwar, S | 1 |
| Shintre, S | 1 |
| Aswar, M | 1 |
| Benson, S | 1 |
| Arck, PC | 1 |
| Tan, S | 1 |
| Hahn, S | 1 |
| Mann, K | 1 |
| Rifaie, N | 1 |
| Janssen, OE | 1 |
| Schedlowski, M | 1 |
| Elsenbruch, S | 1 |
| Moll, E | 1 |
| van Wely, M | 1 |
| Lambalk, CB | 1 |
| Bossuyt, PM | 1 |
| van der Veen, F | 1 |
| Aylwin, S | 1 |
| Al-Zaman, Y | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multi-center, Prospective, Cohort Study to Elucidate the Effects of Metformin Treatment on Steroid Hormones and Social Behavior. Linking Autistic Behaviorial Symptoms to Changes in Steroid Hormone Availability[NCT04930471] | 45 participants (Anticipated) | Observational | 2021-06-30 | Not yet recruiting | |||
| Is the Co-administration of Metformine and CC as Compared to Placebo and CC Superior to Induce Ovulation in PCOS Patients With a Confirmed insulin-resistant-a Double Blind Randomized Clinical Trial[NCT02523898] | Phase 2 | 388 participants (Anticipated) | Interventional | 2015-11-30 | Enrolling by invitation | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for metformin and Anxiety
| Article | Year |
|---|---|
Emerging concepts in the medical and surgical treatment of obesity.
Topics: Adipose Tissue; Amyloid; Anticonvulsants; Antidepressive Agents; Anxiety; Appetite Regulation; Baria | 2008 |
4 trials available for metformin and Anxiety
| Article | Year |
|---|---|
Pioglitazone Metformin Complex Improves Polycystic Ovary Syndrome Comorbid Psychological Distress via Inhibiting NLRP3 Inflammasome Activation: A Prospective Clinical Study.
Topics: Adult; Anxiety; Comorbidity; Depression; Female; Humans; Inflammasomes; Metformin; NLR Family, Pyrin | 2020 |
Comparison of myo-inositol and metformin on mental health parameters and biomarkers of oxidative stress in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial.
Topics: Adult; Anxiety; Biomarkers; Depression; Double-Blind Method; Female; Humans; Hypoglycemic Agents; In | 2018 |
Disturbed stress responses in women with polycystic ovary syndrome.
Topics: Adult; Anxiety; Blood Pressure; Female; Heart Rate; Humans; Hypoglycemic Agents; Hypothalamo-Hypophy | 2009 |
Health-related quality of life in women with newly diagnosed polycystic ovary syndrome randomized between clomifene citrate plus metformin or clomifene citrate plus placebo.
Topics: Adult; Anxiety; Clomiphene; Depression; Double-Blind Method; Female; Fertility Agents, Female; Human | 2012 |
15 other studies available for metformin and Anxiety
| Article | Year |
|---|---|
Metformin modulates microbiota-derived inosine and ameliorates methamphetamine-induced anxiety and depression-like withdrawal symptoms in mice.
Topics: Amphetamine-Related Disorders; Animals; Anxiety; Depression; Inosine; Metformin; Methamphetamine; Mi | 2022 |
TET2 deficiency promotes anxiety and depression-like behaviors by activating NLRP3/IL-1β pathway in microglia of allergic rhinitis mice.
Topics: Animals; Anxiety; Depression; Dioxygenases; DNA-Binding Proteins; Inflammasomes; Metformin; Mice; Mi | 2023 |
The Modulatory Effect of Metformin on Ethanol-Induced Anxiety, Redox Imbalance, and Extracellular Matrix Levels in the Brains of Wistar Rats.
Topics: Animals; Antioxidants; Anxiety; Brain; Ethanol; Extracellular Matrix; Male; Maze Learning; Metformin | 2020 |
Metabolic Alterations Predispose to Seizure Development in High-Fat Diet-Treated Mice: the Role of Metformin.
Topics: Animals; Anxiety; Avoidance Learning; Behavior, Animal; Blood Glucose; Body Composition; Depression; | 2020 |
Protective effect of metformin against ovariectomy induced depressive- and anxiety-like behaviours in rats: role of oxidative stress.
Topics: Animals; Anxiety; Blood Glucose; Depression; Female; Glutathione; Hippocampus; Malondialdehyde; Metf | 2021 |
A pilot trial of metformin for insulin resistance and mood disturbances in adolescent and adult women with polycystic ovary syndrome.
Topics: Adolescent; Adult; Anxiety; Blood Glucose; Body Mass Index; Depression; Female; Humans; Hypoglycemic | 2019 |
Metformin produces anxiolytic-like effects in rats by facilitating GABA
Topics: Animals; Anti-Anxiety Agents; Anxiety; Blood Glucose; Cell Membrane; Cells, Cultured; Dose-Response | 2019 |
Protective role of metformin against methamphetamine induced anxiety, depression, cognition impairment and neurodegeneration in rat: The role of CREB/BDNF and Akt/GSK3 signaling pathways.
Topics: Animals; Anxiety; Brain-Derived Neurotrophic Factor; Central Nervous System Stimulants; Cognitive Dy | 2019 |
Metformin reverses the schizophrenia-like behaviors induced by MK-801 in rats.
Topics: Animals; Antipsychotic Agents; Anxiety; Behavior, Animal; Cognition Disorders; Cognitive Dysfunction | 2019 |
Metformin Promotes Anxiolytic and Antidepressant-Like Responses in Insulin-Resistant Mice by Decreasing Circulating Branched-Chain Amino Acids.
Topics: Amino Acids, Branched-Chain; Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Depressio | 2019 |
Pro-neurocognitive and anti-sarcopenic benefits of one-year metformin therapy in ovariectomized aged mice.
Topics: Aging; Animals; Anxiety; Behavior, Animal; Brain; Cognition; Disease Models, Animal; Drug Administra | 2019 |
Comparison of the independent and combined effects of sub-chronic therapy with metformin and a stable GLP-1 receptor agonist on cognitive function, hippocampal synaptic plasticity and metabolic control in high-fat fed mice.
Topics: Animals; Anxiety; Body Weight; CA1 Region, Hippocampal; Cognition; Diet, High-Fat; Drug Therapy, Com | 2014 |
Metformin improves anxiety-like behaviors through AMPK-dependent regulation of autophagy following transient forebrain ischemia.
Topics: AMP-Activated Protein Kinases; Animals; Anxiety; Autophagy; Brain Ischemia; Male; Metformin; Motor A | 2015 |
Metformin protects the brain against ischemia/reperfusion injury through PI3K/Akt1/JNK3 signaling pathways in rats.
Topics: Animals; Anxiety; Apoptosis; Brain Ischemia; CA1 Region, Hippocampal; Caspase 3; Cognition Disorders | 2017 |
Telmisartan attenuates diabetes induced depression in rats.
Topics: Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Benzimidazoles; Benzoates; Brain; Depress | 2017 |