Page last updated: 2024-10-30

metformin and Anxiety

metformin has been researched along with Anxiety in 20 studies

Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.

Anxiety: Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.

Research Excerpts

ExcerptRelevanceReference
"This study aimed at investigating the therapeutic effect and mechanism of pioglitazone metformin complex preparation (PM) in polycystic ovary syndrome (PCOS) comorbid psychological distress."9.34Pioglitazone Metformin Complex Improves Polycystic Ovary Syndrome Comorbid Psychological Distress via Inhibiting NLRP3 Inflammasome Activation: A Prospective Clinical Study. ( Guo, QJ; Hu, YY; Huang, Q; Huo, CL; Shan, J; Song, JY; Wang, CQ; Xu, YF; Yu, CQ; Zhou, H, 2020)
"Data on comparison of myo-inositol and metformin on mental health parameters and biomarkers of oxidative stress in subjects with polycystic ovary syndrome (PCOS) are scarce."9.27Comparison of myo-inositol and metformin on mental health parameters and biomarkers of oxidative stress in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. ( Afshar Ebrahimi, F; Asemi, Z; Bahmani, F; Foroozanfard, F; Jamilian, H; Jamilian, M, 2018)
"We examine the effects of metformin on insulin resistance (IR) and mood including in adolescent and adult women with polycystic ovary syndrome (PCOS)."7.91A pilot trial of metformin for insulin resistance and mood disturbances in adolescent and adult women with polycystic ovary syndrome. ( Aghamohammadzadeh, N; Erensoy, H; Ghafarzadeh, S; Nader, ND; Niafar, M, 2019)
"According to the data obtained, methamphetamine caused significant depression, anxiety, motor activity disturbances and cognition impairment in experimental animals."7.91Protective role of metformin against methamphetamine induced anxiety, depression, cognition impairment and neurodegeneration in rat: The role of CREB/BDNF and Akt/GSK3 signaling pathways. ( Karami, L; Kermanshahi, S; Keshavarzi, S; Motaghinejad, M; Motevalian, M; Sadr, S, 2019)
" Metformin, widely known as an antidiabetic drug, has been found to enhance spatial memory formation and improve anxiety-like behaviors in rodents."7.91Metformin reverses the schizophrenia-like behaviors induced by MK-801 in rats. ( Li, X; Liu, ZQ; Luo, C; Mao, XY; Wang, X; Yin, JY; Zhang, W; Zhou, HH, 2019)
"Metformin treatment significantly decreased depressive behaviour and malondialdehyde content in the prefrontal cortex."5.62Protective effect of metformin against ovariectomy induced depressive- and anxiety-like behaviours in rats: role of oxidative stress. ( Erdem, S; Ergenc, M; Ozacmak, VH; Sayan Özaçmak, H; Turan, I, 2021)
"Metformin was pretreated for 2 weeks and CC administrated half an hour before global cerebral ischemia."5.42Metformin improves anxiety-like behaviors through AMPK-dependent regulation of autophagy following transient forebrain ischemia. ( Ashabi, G; Badavi, M; Farbood, Y; Khalaj, L; Khodagholi, F; Sarkaki, A, 2015)
"This study aimed at investigating the therapeutic effect and mechanism of pioglitazone metformin complex preparation (PM) in polycystic ovary syndrome (PCOS) comorbid psychological distress."5.34Pioglitazone Metformin Complex Improves Polycystic Ovary Syndrome Comorbid Psychological Distress via Inhibiting NLRP3 Inflammasome Activation: A Prospective Clinical Study. ( Guo, QJ; Hu, YY; Huang, Q; Huo, CL; Shan, J; Song, JY; Wang, CQ; Xu, YF; Yu, CQ; Zhou, H, 2020)
"Data on comparison of myo-inositol and metformin on mental health parameters and biomarkers of oxidative stress in subjects with polycystic ovary syndrome (PCOS) are scarce."5.27Comparison of myo-inositol and metformin on mental health parameters and biomarkers of oxidative stress in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. ( Afshar Ebrahimi, F; Asemi, Z; Bahmani, F; Foroozanfard, F; Jamilian, H; Jamilian, M, 2018)
"We examine the effects of metformin on insulin resistance (IR) and mood including in adolescent and adult women with polycystic ovary syndrome (PCOS)."3.91A pilot trial of metformin for insulin resistance and mood disturbances in adolescent and adult women with polycystic ovary syndrome. ( Aghamohammadzadeh, N; Erensoy, H; Ghafarzadeh, S; Nader, ND; Niafar, M, 2019)
"We examined the effects of metformin on anxiety-like behaviour of rats in open field test and elevated plus maze test."3.91Metformin produces anxiolytic-like effects in rats by facilitating GABA ( Chen, HS; Chen, JG; Fan, J; Huang, JG; Li, D; Wang, F; Xu, JF; Zhu, WW, 2019)
"According to the data obtained, methamphetamine caused significant depression, anxiety, motor activity disturbances and cognition impairment in experimental animals."3.91Protective role of metformin against methamphetamine induced anxiety, depression, cognition impairment and neurodegeneration in rat: The role of CREB/BDNF and Akt/GSK3 signaling pathways. ( Karami, L; Kermanshahi, S; Keshavarzi, S; Motaghinejad, M; Motevalian, M; Sadr, S, 2019)
" Metformin, widely known as an antidiabetic drug, has been found to enhance spatial memory formation and improve anxiety-like behaviors in rodents."3.91Metformin reverses the schizophrenia-like behaviors induced by MK-801 in rats. ( Li, X; Liu, ZQ; Luo, C; Mao, XY; Wang, X; Yin, JY; Zhang, W; Zhou, HH, 2019)
"Metformin treatment significantly decreased depressive behaviour and malondialdehyde content in the prefrontal cortex."1.62Protective effect of metformin against ovariectomy induced depressive- and anxiety-like behaviours in rats: role of oxidative stress. ( Erdem, S; Ergenc, M; Ozacmak, VH; Sayan Özaçmak, H; Turan, I, 2021)
"Metformin was pretreated for 2 weeks and CC administrated half an hour before global cerebral ischemia."1.42Metformin improves anxiety-like behaviors through AMPK-dependent regulation of autophagy following transient forebrain ischemia. ( Ashabi, G; Badavi, M; Farbood, Y; Khalaj, L; Khodagholi, F; Sarkaki, A, 2015)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (10.00)29.6817
2010's12 (60.00)24.3611
2020's6 (30.00)2.80

Authors

AuthorsStudies
Yang, J1
Zhang, Z1
Xie, Z1
Bai, L1
Xiong, P1
Chen, F1
Zhu, T1
Peng, Q1
Wu, H1
Zhou, Y1
Ma, Y1
Zhang, Y1
Chen, M1
Gao, J1
Tian, W1
Shi, K1
Du, Y1
Duan, Y1
Wang, H1
Xu, Y2
Kuang, YQ1
Zhu, M1
Yu, J1
Wang, K1
Gao, Z1
Lv, H1
Wang, Y1
Xie, Y1
Guan, M1
Guo, QJ1
Shan, J1
Xu, YF1
Hu, YY1
Huo, CL1
Song, JY1
Wang, CQ1
Zhou, H1
Yu, CQ1
Huang, Q1
Bonea, M1
Filip, GA1
Toma, VA1
Baldea, I1
Berghian, AS1
Decea, N1
Olteanu, D1
Moldovan, R1
Crivii, C1
Vinași, RC1
Micluția, IV1
Nesci, V1
Russo, E1
Arcidiacono, B1
Citraro, R1
Tallarico, M1
Constanti, A1
Brunetti, A1
De Sarro, G1
Leo, A1
Turan, I1
Sayan Özaçmak, H1
Erdem, S1
Ergenc, M1
Ozacmak, VH1
Jamilian, H1
Jamilian, M1
Foroozanfard, F1
Afshar Ebrahimi, F1
Bahmani, F1
Asemi, Z1
Erensoy, H1
Niafar, M1
Ghafarzadeh, S1
Aghamohammadzadeh, N1
Nader, ND1
Fan, J1
Li, D1
Chen, HS1
Huang, JG1
Xu, JF1
Zhu, WW1
Chen, JG1
Wang, F1
Keshavarzi, S1
Kermanshahi, S1
Karami, L1
Motaghinejad, M1
Motevalian, M1
Sadr, S1
Wang, X1
Luo, C1
Mao, XY1
Li, X1
Yin, JY1
Zhang, W1
Zhou, HH1
Liu, ZQ1
Zemdegs, J1
Martin, H1
Pintana, H1
Bullich, S1
Manta, S1
Marqués, MA1
Moro, C1
Layé, S1
Ducrocq, F1
Chattipakorn, N1
Chattipakorn, SC1
Rampon, C1
Pénicaud, L1
Fioramonti, X1
Guiard, BP1
Zakeri, M1
Fatemi, I1
Kaeidi, A1
Zakeri, MA1
Hakimizadeh, E1
Hassanipour, M1
Rahmani, M1
Hassanshahi, J1
Ayoobi, F1
Allahtavakoli, M1
Lennox, R1
Porter, DW1
Flatt, PR1
Holscher, C1
Irwin, N1
Gault, VA1
Sarkaki, A1
Farbood, Y1
Badavi, M1
Khalaj, L1
Khodagholi, F1
Ashabi, G1
Ge, XH1
Zhu, GJ1
Geng, DQ1
Zhang, HZ1
He, JM1
Guo, AZ1
Ma, LL1
Yu, DH1
Aswar, U1
Chepurwar, S1
Shintre, S1
Aswar, M1
Benson, S1
Arck, PC1
Tan, S1
Hahn, S1
Mann, K1
Rifaie, N1
Janssen, OE1
Schedlowski, M1
Elsenbruch, S1
Moll, E1
van Wely, M1
Lambalk, CB1
Bossuyt, PM1
van der Veen, F1
Aylwin, S1
Al-Zaman, Y1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Multi-center, Prospective, Cohort Study to Elucidate the Effects of Metformin Treatment on Steroid Hormones and Social Behavior. Linking Autistic Behaviorial Symptoms to Changes in Steroid Hormone Availability[NCT04930471]45 participants (Anticipated)Observational2021-06-30Not yet recruiting
Is the Co-administration of Metformine and CC as Compared to Placebo and CC Superior to Induce Ovulation in PCOS Patients With a Confirmed insulin-resistant-a Double Blind Randomized Clinical Trial[NCT02523898]Phase 2388 participants (Anticipated)Interventional2015-11-30Enrolling by invitation
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for metformin and Anxiety

ArticleYear
Emerging concepts in the medical and surgical treatment of obesity.
    Frontiers of hormone research, 2008, Volume: 36

    Topics: Adipose Tissue; Amyloid; Anticonvulsants; Antidepressive Agents; Anxiety; Appetite Regulation; Baria

2008

Trials

4 trials available for metformin and Anxiety

ArticleYear
Pioglitazone Metformin Complex Improves Polycystic Ovary Syndrome Comorbid Psychological Distress via Inhibiting NLRP3 Inflammasome Activation: A Prospective Clinical Study.
    Mediators of inflammation, 2020, Volume: 2020

    Topics: Adult; Anxiety; Comorbidity; Depression; Female; Humans; Inflammasomes; Metformin; NLR Family, Pyrin

2020
Comparison of myo-inositol and metformin on mental health parameters and biomarkers of oxidative stress in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial.
    Journal of psychosomatic obstetrics and gynaecology, 2018, Volume: 39, Issue:4

    Topics: Adult; Anxiety; Biomarkers; Depression; Double-Blind Method; Female; Humans; Hypoglycemic Agents; In

2018
Disturbed stress responses in women with polycystic ovary syndrome.
    Psychoneuroendocrinology, 2009, Volume: 34, Issue:5

    Topics: Adult; Anxiety; Blood Pressure; Female; Heart Rate; Humans; Hypoglycemic Agents; Hypothalamo-Hypophy

2009
Health-related quality of life in women with newly diagnosed polycystic ovary syndrome randomized between clomifene citrate plus metformin or clomifene citrate plus placebo.
    Human reproduction (Oxford, England), 2012, Volume: 27, Issue:11

    Topics: Adult; Anxiety; Clomiphene; Depression; Double-Blind Method; Female; Fertility Agents, Female; Human

2012

Other Studies

15 other studies available for metformin and Anxiety

ArticleYear
Metformin modulates microbiota-derived inosine and ameliorates methamphetamine-induced anxiety and depression-like withdrawal symptoms in mice.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 149

    Topics: Amphetamine-Related Disorders; Animals; Anxiety; Depression; Inosine; Metformin; Methamphetamine; Mi

2022
TET2 deficiency promotes anxiety and depression-like behaviors by activating NLRP3/IL-1β pathway in microglia of allergic rhinitis mice.
    Molecular medicine (Cambridge, Mass.), 2023, Nov-27, Volume: 29, Issue:1

    Topics: Animals; Anxiety; Depression; Dioxygenases; DNA-Binding Proteins; Inflammasomes; Metformin; Mice; Mi

2023
The Modulatory Effect of Metformin on Ethanol-Induced Anxiety, Redox Imbalance, and Extracellular Matrix Levels in the Brains of Wistar Rats.
    Journal of molecular neuroscience : MN, 2020, Volume: 70, Issue:12

    Topics: Animals; Antioxidants; Anxiety; Brain; Ethanol; Extracellular Matrix; Male; Maze Learning; Metformin

2020
Metabolic Alterations Predispose to Seizure Development in High-Fat Diet-Treated Mice: the Role of Metformin.
    Molecular neurobiology, 2020, Volume: 57, Issue:11

    Topics: Animals; Anxiety; Avoidance Learning; Behavior, Animal; Blood Glucose; Body Composition; Depression;

2020
Protective effect of metformin against ovariectomy induced depressive- and anxiety-like behaviours in rats: role of oxidative stress.
    Neuroreport, 2021, 05-19, Volume: 32, Issue:8

    Topics: Animals; Anxiety; Blood Glucose; Depression; Female; Glutathione; Hippocampus; Malondialdehyde; Metf

2021
A pilot trial of metformin for insulin resistance and mood disturbances in adolescent and adult women with polycystic ovary syndrome.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2019, Volume: 35, Issue:1

    Topics: Adolescent; Adult; Anxiety; Blood Glucose; Body Mass Index; Depression; Female; Humans; Hypoglycemic

2019
Metformin produces anxiolytic-like effects in rats by facilitating GABA
    British journal of pharmacology, 2019, Volume: 176, Issue:2

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Blood Glucose; Cell Membrane; Cells, Cultured; Dose-Response

2019
Protective role of metformin against methamphetamine induced anxiety, depression, cognition impairment and neurodegeneration in rat: The role of CREB/BDNF and Akt/GSK3 signaling pathways.
    Neurotoxicology, 2019, Volume: 72

    Topics: Animals; Anxiety; Brain-Derived Neurotrophic Factor; Central Nervous System Stimulants; Cognitive Dy

2019
Metformin reverses the schizophrenia-like behaviors induced by MK-801 in rats.
    Brain research, 2019, 09-15, Volume: 1719

    Topics: Animals; Antipsychotic Agents; Anxiety; Behavior, Animal; Cognition Disorders; Cognitive Dysfunction

2019
Metformin Promotes Anxiolytic and Antidepressant-Like Responses in Insulin-Resistant Mice by Decreasing Circulating Branched-Chain Amino Acids.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019, 07-24, Volume: 39, Issue:30

    Topics: Amino Acids, Branched-Chain; Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Depressio

2019
Pro-neurocognitive and anti-sarcopenic benefits of one-year metformin therapy in ovariectomized aged mice.
    Clinical and experimental pharmacology & physiology, 2019, Volume: 46, Issue:12

    Topics: Aging; Animals; Anxiety; Behavior, Animal; Brain; Cognition; Disease Models, Animal; Drug Administra

2019
Comparison of the independent and combined effects of sub-chronic therapy with metformin and a stable GLP-1 receptor agonist on cognitive function, hippocampal synaptic plasticity and metabolic control in high-fat fed mice.
    Neuropharmacology, 2014, Volume: 86

    Topics: Animals; Anxiety; Body Weight; CA1 Region, Hippocampal; Cognition; Diet, High-Fat; Drug Therapy, Com

2014
Metformin improves anxiety-like behaviors through AMPK-dependent regulation of autophagy following transient forebrain ischemia.
    Metabolic brain disease, 2015, Volume: 30, Issue:5

    Topics: AMP-Activated Protein Kinases; Animals; Anxiety; Autophagy; Brain Ischemia; Male; Metformin; Motor A

2015
Metformin protects the brain against ischemia/reperfusion injury through PI3K/Akt1/JNK3 signaling pathways in rats.
    Physiology & behavior, 2017, 03-01, Volume: 170

    Topics: Animals; Anxiety; Apoptosis; Brain Ischemia; CA1 Region, Hippocampal; Caspase 3; Cognition Disorders

2017
Telmisartan attenuates diabetes induced depression in rats.
    Pharmacological reports : PR, 2017, Volume: 69, Issue:2

    Topics: Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Benzimidazoles; Benzoates; Brain; Depress

2017