Page last updated: 2024-10-30

metformin and Anoxemia

metformin has been researched along with Anoxemia in 39 studies

Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.

Research Excerpts

ExcerptRelevanceReference
"This study demonstrates that HIF1α stimulates both TG2 expression and activity via ZEB2/TRPC6 axis, whereas abrogation of HIF1α by metformin prevented hypoxia-induced glomerular injury."8.31Metformin prevents hypoxia-induced podocyte injury by regulating the ZEB2/TG2 axis. ( Kavvuri, R; Kolligundla, LP; Mukhi, D; Pasupulati, AK; Singh, AK, 2023)
"Activated CD8 T cells were exposed to hypoxia and metformin and analyzed by fluorescence-activated cell sorting for cell proliferation, apoptosis and phenotype."8.31Metformin improves cancer immunotherapy by directly rescuing tumor-infiltrating CD8 T lymphocytes from hypoxia-induced immunosuppression. ( Dvorakova, T; Finisguerra, V; Formenti, M; Gallez, B; Mignion, L; Van den Eynde, BJ; Van Meerbeeck, P, 2023)
"Metformin metabolism is slowed down in T2DM patients in the hypoxic environment of the plateau; the glucose-lowering effect of the plateau is similar, and the attainment rate is low, the possibility of having serious adverse effects of lactic acidosis is higher in T2DM patients on the plateau than on the control one."8.31Effects of plateau hypoxia on population pharmacokinetics and pharmacodynamics of metformin in patients with Type 2 diabetes. ( Hu, L; Li, W; Luo, L; Luo, X; Qin, N; Shen, Y; Sun, Y; Wang, R; Wang, Z, 2023)
" In this study, we investigated the potential effects of acute systemic hypoxia itself and in combination with metformin on hepatocellular carcinoma (HCC) growth and metastasis in a mouse model of HCC."7.96Systemic hypoxia potentiates anti-tumor effects of metformin in hepatocellular carcinoma in mice. ( Huang, Y; Lin, H; Ren, M; Wang, H; Xu, F; Zhou, W, 2020)
"Metformin attenuates diabetes-induced renal medullary tissue hypoxia in an animal model of insulinopenic type 1 diabetes."7.91Metformin attenuates renal medullary hypoxia in diabetic nephropathy through inhibition uncoupling protein-2. ( Christensen, M; Gustafsson, H; Krag, SP; Nørregaard, R; Palm, F; Schiffer, TA, 2019)
" Both metformin and resveratrol effectively inhibited HIF-1α activation-induced fibrosis and inflammation in adipose tissue, although by different mechanisms."7.83The role of metformin and resveratrol in the prevention of hypoxia-inducible factor 1α accumulation and fibrosis in hypoxic adipose tissue. ( Huang, F; Kou, J; Li, A; Li, J; Li, X; Liu, B; Liu, K; Qi, LW; Qiu, Z; Wang, L, 2016)
"This study aims to investigate the effects of metformin and resveratrol on muscle insulin resistance with emphasis on the regulation of lipolysis in hypoxic adipose tissue."7.83Metformin and resveratrol ameliorate muscle insulin resistance through preventing lipolysis and inflammation in hypoxic adipose tissue. ( Feng, X; Hou, T; Li, A; Liu, B; Liu, K; Zhang, N; Zhao, W, 2016)
"To determine the respective role of metformin accumulation and tissue hypoxia in triggering metformin-associated lactic acidosis (MALA), we measured plasma (PM) and red blood cell (RM) metformin concentrations in 14 patients with MALA and in 58 diabetic patients on well-tolerated chronic metformin treatment."7.69Metformin-associated lactic acidosis in diabetic patients with acute renal failure. A critical analysis of its pathogenesis and prognosis. ( De Cagny, B; Fournier, A; Lacroix, C; Lalau, JD, 1994)
"Multiple cancers have been reported to be associated with angiogenesis and are sensitive to anti-angiogenic therapies."5.91Metformin and simvastatin synergistically suppress endothelin 1-induced hypoxia and angiogenesis in multiple cancer types. ( Chen, H; Gao, X; Li, J; Li, Y; Liu, J; Liu, P; Ren, Y; Song, S; Wang, B; Wang, H; Wang, R; Wang, Y; Zhang, M, 2023)
"Metformin treatment after hypoxia-ischaemia had no effect on microglia number and proliferation, but significantly reduced microglia activation in all regions examined, concomitant with improved behavioural outcomes in injured mice."5.72Reduced microglia activation following metformin administration or microglia ablation is sufficient to prevent functional deficits in a mouse model of neonatal stroke. ( Adams, KV; Bourget, C; Morshead, CM, 2022)
" Patients underwent screening positron emission tomography (PET) imaging with hypoxia tracer fluoroazomycin arabinoside (FAZA)."5.51A Phase II Randomized Trial of Chemoradiation with or without Metformin in Locally Advanced Cervical Cancer. ( Bruce, J; Cairns, R; Chaudary, N; Croke, J; D'Souza, D; Dhani, N; Fyles, A; Han, K; Jaffray, D; Koritzinsky, M; Lee, TY; Metser, U; Milosevic, M; Pakbaz, S; Pintilie, M; Rouzbahman, M; Shek, T; Vines, D, 2022)
"Metformin (MTF) has been reported to target NLK (Nemo-like kinase) to inhibit non-small lung cancer cells."5.48Metformin Enhances the Effect of Regorafenib and Inhibits Recurrence and Metastasis of Hepatic Carcinoma After Liver Resection via Regulating Expression of Hypoxia Inducible Factors 2α (HIF-2α) and 30 kDa HIV Tat-Interacting Protein (TIP30). ( Guo, X; Yang, L; Yang, Q, 2018)
"Metformin is a first-line drug for the management of type 2 diabetes."5.43Metformin Protects H9C2 Cardiomyocytes from High-Glucose and Hypoxia/Reoxygenation Injury via Inhibition of Reactive Oxygen Species Generation and Inflammatory Responses: Role of AMPK and JNK. ( Chen, M; Hu, M; Liao, H; Yang, F; Ye, P, 2016)
"This study demonstrates that HIF1α stimulates both TG2 expression and activity via ZEB2/TRPC6 axis, whereas abrogation of HIF1α by metformin prevented hypoxia-induced glomerular injury."4.31Metformin prevents hypoxia-induced podocyte injury by regulating the ZEB2/TG2 axis. ( Kavvuri, R; Kolligundla, LP; Mukhi, D; Pasupulati, AK; Singh, AK, 2023)
"Activated CD8 T cells were exposed to hypoxia and metformin and analyzed by fluorescence-activated cell sorting for cell proliferation, apoptosis and phenotype."4.31Metformin improves cancer immunotherapy by directly rescuing tumor-infiltrating CD8 T lymphocytes from hypoxia-induced immunosuppression. ( Dvorakova, T; Finisguerra, V; Formenti, M; Gallez, B; Mignion, L; Van den Eynde, BJ; Van Meerbeeck, P, 2023)
"Metformin metabolism is slowed down in T2DM patients in the hypoxic environment of the plateau; the glucose-lowering effect of the plateau is similar, and the attainment rate is low, the possibility of having serious adverse effects of lactic acidosis is higher in T2DM patients on the plateau than on the control one."4.31Effects of plateau hypoxia on population pharmacokinetics and pharmacodynamics of metformin in patients with Type 2 diabetes. ( Hu, L; Li, W; Luo, L; Luo, X; Qin, N; Shen, Y; Sun, Y; Wang, R; Wang, Z, 2023)
" The effect of metformin on HIF-1 activity was analyzed by quantification of HIF target gene expression and HIF-1 protein stabilization in human mesothelial cells and murine fibroblast under normoxia and hypoxia."4.12Effect of Metformin on HIF-1α Signaling and Postoperative Adhesion Formation. ( Biller, ML; Bleul, M; Dupovac, M; Harnoss, JM; Keppler, U; Probst, P; Schneider, M; Strowitzki, MJ; Tran, DT; Tuffs, C, 2022)
" In this study, we investigated the potential effects of acute systemic hypoxia itself and in combination with metformin on hepatocellular carcinoma (HCC) growth and metastasis in a mouse model of HCC."3.96Systemic hypoxia potentiates anti-tumor effects of metformin in hepatocellular carcinoma in mice. ( Huang, Y; Lin, H; Ren, M; Wang, H; Xu, F; Zhou, W, 2020)
"Metformin attenuates diabetes-induced renal medullary tissue hypoxia in an animal model of insulinopenic type 1 diabetes."3.91Metformin attenuates renal medullary hypoxia in diabetic nephropathy through inhibition uncoupling protein-2. ( Christensen, M; Gustafsson, H; Krag, SP; Nørregaard, R; Palm, F; Schiffer, TA, 2019)
"Previous studies have shown that metformin (MET) prevents experimental pulmonary arterial hypertension (PAH) and that activation of autophagy is involved in the development of pulmonary vascular remodeling."3.91Metformin Prevents Progression of Experimental Pulmonary Hypertension via Inhibition of Autophagy and Activation of Adenosine Monophosphate-Activated Protein Kinase. ( Li, H; Liu, Y; Sun, Z; Xu, Y; Yang, G; Zhang, J; Zhu, J, 2019)
" Both metformin and resveratrol effectively inhibited HIF-1α activation-induced fibrosis and inflammation in adipose tissue, although by different mechanisms."3.83The role of metformin and resveratrol in the prevention of hypoxia-inducible factor 1α accumulation and fibrosis in hypoxic adipose tissue. ( Huang, F; Kou, J; Li, A; Li, J; Li, X; Liu, B; Liu, K; Qi, LW; Qiu, Z; Wang, L, 2016)
"This study aims to investigate the effects of metformin and resveratrol on muscle insulin resistance with emphasis on the regulation of lipolysis in hypoxic adipose tissue."3.83Metformin and resveratrol ameliorate muscle insulin resistance through preventing lipolysis and inflammation in hypoxic adipose tissue. ( Feng, X; Hou, T; Li, A; Liu, B; Liu, K; Zhang, N; Zhao, W, 2016)
"To determine the respective role of metformin accumulation and tissue hypoxia in triggering metformin-associated lactic acidosis (MALA), we measured plasma (PM) and red blood cell (RM) metformin concentrations in 14 patients with MALA and in 58 diabetic patients on well-tolerated chronic metformin treatment."3.69Metformin-associated lactic acidosis in diabetic patients with acute renal failure. A critical analysis of its pathogenesis and prognosis. ( De Cagny, B; Fournier, A; Lacroix, C; Lalau, JD, 1994)
"The primary composite end point was hypoxemia (≤93% oxygen saturation on home oximetry), emergency department visit, hospitalization, or death."3.11Randomized Trial of Metformin, Ivermectin, and Fluvoxamine for Covid-19. ( Anderson, B; Avula, N; Belani, HK; Biros, M; Boulware, DR; Bramante, CT; Buse, JB; Cohen, K; Erickson, SM; Fenno, SL; Fricton, R; Hagen, AA; Hartman, KM; Huling, JD; Ingraham, NE; Karger, AB; Klatt, NR; Lee, S; Liebovitz, DM; Lindberg, S; Luke, DG; Murray, TA; Nicklas, JM; Odde, DJ; Patel, B; Proper, JL; Pullen, MF; Puskarich, MA; Rao, V; Reddy, NV; Saveraid, HG; Sherwood, NE; Siegel, LK; Thompson, JL; Tignanelli, CJ; Tordsen, WJ; Zaman, A, 2022)
"Multiple cancers have been reported to be associated with angiogenesis and are sensitive to anti-angiogenic therapies."1.91Metformin and simvastatin synergistically suppress endothelin 1-induced hypoxia and angiogenesis in multiple cancer types. ( Chen, H; Gao, X; Li, J; Li, Y; Liu, J; Liu, P; Ren, Y; Song, S; Wang, B; Wang, H; Wang, R; Wang, Y; Zhang, M, 2023)
"Metformin is a glucose-lowering, insulin-sensitizing drug that is commonly used in the treatment of type 2 diabetes (T2D)."1.91Chronic Metformin Administration Does Not Alter Carotid Sinus Nerve Activity in Control Rats. ( Conde, SV; Melo, BF; Prieto-Lloret, J; Sacramento, JF, 2023)
"Apical periodontitis was induced in mandibular first molars of 10 Sprague-Dawley rats."1.91Metformin Reduces Bone Resorption in Apical Periodontitis Through Regulation of Osteoblast and Osteoclast Differentiation. ( Chen, MH; Cheng, SJ; Hong, CY; Kok, SH; Lai, EH; Lin, HY; Lin, SK; Shun, CT; Wang, HW; Wu, FY; Yang, CN; Yang, H, 2023)
"Metformin treatment after hypoxia-ischaemia had no effect on microglia number and proliferation, but significantly reduced microglia activation in all regions examined, concomitant with improved behavioural outcomes in injured mice."1.72Reduced microglia activation following metformin administration or microglia ablation is sufficient to prevent functional deficits in a mouse model of neonatal stroke. ( Adams, KV; Bourget, C; Morshead, CM, 2022)
"Metformin (MTF) has been reported to target NLK (Nemo-like kinase) to inhibit non-small lung cancer cells."1.48Metformin Enhances the Effect of Regorafenib and Inhibits Recurrence and Metastasis of Hepatic Carcinoma After Liver Resection via Regulating Expression of Hypoxia Inducible Factors 2α (HIF-2α) and 30 kDa HIV Tat-Interacting Protein (TIP30). ( Guo, X; Yang, L; Yang, Q, 2018)
"Metformin is a first-line drug for the management of type 2 diabetes."1.43Metformin Protects H9C2 Cardiomyocytes from High-Glucose and Hypoxia/Reoxygenation Injury via Inhibition of Reactive Oxygen Species Generation and Inflammatory Responses: Role of AMPK and JNK. ( Chen, M; Hu, M; Liao, H; Yang, F; Ye, P, 2016)
"Metformin (200 mg/kg) was administrated for up to 14 days."1.40Metformin attenuates blood-brain barrier disruption in mice following middle cerebral artery occlusion. ( Chen, X; Gu, X; Li, Y; Liu, Y; Tang, G; Wang, Y; Yang, GY; Zhang, Z, 2014)
"Wildtype C."1.37Environmental and genetic preconditioning for long-term anoxia responses requires AMPK in Caenorhabditis elegans. ( LaRue, BL; Padilla, PA, 2011)

Research

Studies (39)

TimeframeStudies, this research(%)All Research%
pre-19902 (5.13)18.7374
1990's1 (2.56)18.2507
2000's2 (5.13)29.6817
2010's16 (41.03)24.3611
2020's18 (46.15)2.80

Authors

AuthorsStudies
Jankeviciute, S1
Svirskiene, N2
Svirskis, G2
Borutaite, V2
Biller, ML1
Tuffs, C1
Bleul, M1
Tran, DT1
Dupovac, M1
Keppler, U1
Harnoss, JM1
Probst, P1
Schneider, M1
Strowitzki, MJ1
Bourget, C1
Adams, KV1
Morshead, CM1
Han, K1
Fyles, A1
Shek, T1
Croke, J1
Dhani, N1
D'Souza, D1
Lee, TY1
Chaudary, N1
Bruce, J1
Pintilie, M1
Cairns, R1
Vines, D1
Pakbaz, S1
Jaffray, D1
Metser, U1
Rouzbahman, M1
Milosevic, M1
Koritzinsky, M1
Bramante, CT1
Huling, JD1
Tignanelli, CJ1
Buse, JB1
Liebovitz, DM1
Nicklas, JM1
Cohen, K1
Puskarich, MA1
Belani, HK1
Proper, JL1
Siegel, LK1
Klatt, NR1
Odde, DJ1
Luke, DG1
Anderson, B1
Karger, AB1
Ingraham, NE1
Hartman, KM1
Rao, V1
Hagen, AA1
Patel, B1
Fenno, SL1
Avula, N1
Reddy, NV1
Erickson, SM1
Lindberg, S1
Fricton, R1
Lee, S1
Zaman, A1
Saveraid, HG1
Tordsen, WJ1
Pullen, MF1
Biros, M1
Sherwood, NE1
Thompson, JL1
Boulware, DR1
Murray, TA1
Liu, J2
Wang, H2
Zhang, M1
Li, Y2
Wang, R2
Chen, H2
Wang, B1
Gao, X1
Song, S1
Wang, Y4
Ren, Y1
Li, J3
Liu, P1
Yang, Z1
Qiao, C1
Jia, Q1
Chen, Z1
Wang, X1
Liu, X1
Zhang, R1
Pu, K1
Wang, Z2
Kolligundla, LP1
Kavvuri, R1
Singh, AK1
Mukhi, D1
Pasupulati, AK1
Yamaguchi, A1
Mukai, Y1
Sakuma, T1
Narumi, K1
Furugen, A1
Yamada, Y1
Kobayashi, M1
Finisguerra, V1
Dvorakova, T1
Formenti, M1
Van Meerbeeck, P1
Mignion, L1
Gallez, B1
Van den Eynde, BJ1
Sacramento, JF1
Melo, BF1
Prieto-Lloret, J1
Conde, SV1
Shen, Y1
Luo, X1
Qin, N1
Hu, L1
Luo, L1
Sun, Y1
Li, W1
Hong, CY1
Lin, SK1
Wang, HW1
Shun, CT1
Yang, CN1
Lai, EH1
Cheng, SJ1
Chen, MH1
Yang, H1
Lin, HY1
Wu, FY1
Kok, SH1
Yang, J1
Zhang, C1
Chen, X2
Zhou, D1
Sun, Z2
Niu, R1
Zhu, Y1
Wang, L2
Chen, Y2
Fu, Y1
Ma, N1
Luo, Y1
Tsenova, L1
Singhal, A1
Lin, H1
Zhou, W1
Huang, Y1
Ren, M1
Xu, F1
Pampuscenko, K1
Roos, FJM1
Bijvelds, MJC1
Verstegen, MMA1
Roest, HP1
Metselaar, HJ1
Polak, WG1
Jonge, HR1
IJzermans, JNM1
van der Laan, LJW1
Yang, Q1
Guo, X1
Yang, L1
Christensen, M1
Schiffer, TA1
Gustafsson, H1
Krag, SP1
Nørregaard, R1
Palm, F1
Zhao, M1
Cheng, X1
Lin, X1
Han, Y1
Zhou, Y1
Zhao, T1
He, Y1
Wu, L1
Zhao, Y1
Fan, M1
Zhu, L1
Liu, Y2
Xu, Y1
Zhu, J1
Li, H1
Zhang, J1
Yang, G1
Garofalo, C1
Capristo, M1
Manara, MC1
Mancarella, C1
Landuzzi, L1
Belfiore, A1
Lollini, PL1
Picci, P1
Scotlandi, K1
Takiyama, Y1
Haneda, M1
Tang, G1
Gu, X1
Zhang, Z1
Yang, GY1
Zhou, X1
Chen, J1
Yi, G1
Deng, M1
Liu, H1
Liang, M1
Shi, B1
Fu, X1
Chen, L1
He, Z1
Wang, J1
Houssaini, A1
Abid, S1
Derumeaux, G1
Wan, F1
Parpaleix, A1
Rideau, D1
Marcos, E1
Kebe, K1
Czibik, G1
Sawaki, D1
Treins, C1
Dubois-Randé, JL1
Li, Z1
Amsellem, V1
Lipskaia, L1
Pende, M1
Adnot, S1
Li, X1
Li, A2
Qiu, Z1
Qi, LW1
Kou, J1
Liu, K2
Liu, B2
Huang, F1
Desir, S1
Dickson, EL1
Vogel, RI1
Thayanithy, V1
Wong, P1
Teoh, D1
Geller, MA1
Steer, CJ1
Subramanian, S1
Lou, E1
Hu, M1
Ye, P1
Liao, H1
Chen, M1
Yang, F1
Zhao, W1
Feng, X1
Hou, T1
Zhang, N1
van den Nouland, DP1
Brouwers, MC1
Stassen, PM1
LaRue, BL1
Padilla, PA1
Wang, S1
Song, P1
Zou, MH1
Mielke, JG1
Taghibiglou, C1
Wang, YT1
Lalau, JD1
Lacroix, C1
De Cagny, B1
Fournier, A1
Cosić, V1
Antić, S1
Pesić, M1
Jovanović, O1
Kundalić, S1
Djordjević, VB1
Duwoos, H1
Bertrand, CM1
Husson, A1
Cramer, J1
Tayot, J1
Debry, G1
Laurent, J1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
COVID-OUT: Early Outpatient Treatment for SARS-CoV-2 Infection (COVID-19)[NCT04510194]Phase 31,323 participants (Actual)Interventional2021-01-01Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Count of Participants Who Died

(NCT04510194)
Timeframe: 14 days

InterventionParticipants (Count of Participants)
Treatment Arm - Metformin Only Group0
Treatment Arm - Placebo Group0
Treatment Arm - Ivermectin Only Group0
Treatment Arm - Fluvoxamine Only Group0
Treatment Arm - Metformin and Fluvoxamine Group0
Treatment Arm - Metformin and Ivermectin Group1

Count of Participants With ED Visit, Hospitalization or Death

(NCT04510194)
Timeframe: 14 days

InterventionParticipants (Count of Participants)
Treatment Arm - Metformin Only Group27
Treatment Arm - Placebo Group48
Treatment Arm - Ivermectin Only Group16
Treatment Arm - Fluvoxamine Only Group15
Treatment Arm - Metformin and Fluvoxamine Group18
Treatment Arm - Metformin and Ivermectin Group23

Count of Participants With Hospitalization or Death

(NCT04510194)
Timeframe: 14 days

InterventionParticipants (Count of Participants)
Treatment Arm - Metformin Only Group8
Treatment Arm - Placebo Group18
Treatment Arm - Ivermectin Only Group5
Treatment Arm - Fluvoxamine Only Group5
Treatment Arm - Metformin and Fluvoxamine Group6
Treatment Arm - Metformin and Ivermectin Group4

Count of Participants With Hypoxia Only

(NCT04510194)
Timeframe: 14 days

InterventionParticipants (Count of Participants)
Treatment Arm - Metformin Only Group147
Treatment Arm - Placebo Group158
Treatment Arm - Ivermectin Only Group88
Treatment Arm - Fluvoxamine Only Group73
Treatment Arm - Metformin and Fluvoxamine Group71
Treatment Arm - Metformin and Ivermectin Group96

Reviews

3 reviews available for metformin and Anoxemia

ArticleYear
Effects of host-directed therapies on the pathology of tuberculosis.
    The Journal of pathology, 2020, Volume: 250, Issue:5

    Topics: Host-Pathogen Interactions; Humans; Hypoxia; Metformin; Mycobacterium tuberculosis; Neutrophils; Tub

2020
Hypoxia in diabetic kidneys.
    BioMed research international, 2014, Volume: 2014

    Topics: Adenosine Triphosphate; Animals; Diabetes Mellitus; Diabetic Nephropathies; Glomerular Filtration Ra

2014
AMP-activated protein kinase, stress responses and cardiovascular diseases.
    Clinical science (London, England : 1979), 2012, Volume: 122, Issue:12

    Topics: AMP-Activated Protein Kinases; Animals; Antioxidants; Autophagy; Cardiovascular Diseases; Cell Proli

2012

Trials

2 trials available for metformin and Anoxemia

ArticleYear
A Phase II Randomized Trial of Chemoradiation with or without Metformin in Locally Advanced Cervical Cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2022, 12-15, Volume: 28, Issue:24

    Topics: COVID-19; Female; Humans; Hypoxia; Metformin; Nitroimidazoles; Pandemics; Positron Emission Tomograp

2022
Randomized Trial of Metformin, Ivermectin, and Fluvoxamine for Covid-19.
    The New England journal of medicine, 2022, 08-18, Volume: 387, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; COVID-19; COVID-19 Drug Treatment; COVID-19 Vaccines; Double-Blind M

2022

Other Studies

34 other studies available for metformin and Anoxemia

ArticleYear
Effects of Metformin on Spontaneous Ca
    International journal of molecular sciences, 2021, Aug-31, Volume: 22, Issue:17

    Topics: Animals; Caffeine; Calcium Signaling; Chromans; Cyclosporine; Electron Transport Complex I; Female;

2021
Effect of Metformin on HIF-1α Signaling and Postoperative Adhesion Formation.
    Journal of the American College of Surgeons, 2022, 06-01, Volume: 234, Issue:6

    Topics: Animals; Humans; Hypoglycemic Agents; Hypoxia; Metformin; Mice; Signal Transduction; Tissue Adhesion

2022
Reduced microglia activation following metformin administration or microglia ablation is sufficient to prevent functional deficits in a mouse model of neonatal stroke.
    Journal of neuroinflammation, 2022, Jun-15, Volume: 19, Issue:1

    Topics: Animals; Animals, Newborn; Disease Models, Animal; Hypoxia; Hypoxia-Ischemia, Brain; Metformin; Mice

2022
Metformin and simvastatin synergistically suppress endothelin 1-induced hypoxia and angiogenesis in multiple cancer types.
    Cancer science, 2023, Volume: 114, Issue:2

    Topics: Animals; Cell Line, Tumor; Endothelin-1; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Metform

2023
Redox dyshomeostasis modulation of the tumor intracellular environment through a metabolic intervention strategy for enhanced photodynamic therapy.
    Theranostics, 2022, Volume: 12, Issue:14

    Topics: Buthionine Sulfoximine; Cell Line, Tumor; Glutathione; Humans; Hypoxia; Lipids; Metal-Organic Framew

2022
Metformin prevents hypoxia-induced podocyte injury by regulating the ZEB2/TG2 axis.
    Nephrology (Carlton, Vic.), 2023, Volume: 28, Issue:1

    Topics: Animals; Hypoxia; Metformin; Mice; Podocytes; Protein Glutamine gamma Glutamyltransferase 2; Renal I

2023
Monocarboxylate transporter 4 involves in energy metabolism and drug sensitivity in hypoxia.
    Scientific reports, 2023, 01-27, Volume: 13, Issue:1

    Topics: Cell Hypoxia; Cell Line, Tumor; Energy Metabolism; Glycolysis; Humans; Hypoxia; Hypoxia-Inducible Fa

2023
Metformin improves cancer immunotherapy by directly rescuing tumor-infiltrating CD8 T lymphocytes from hypoxia-induced immunosuppression.
    Journal for immunotherapy of cancer, 2023, Volume: 11, Issue:5

    Topics: Animals; CD8-Positive T-Lymphocytes; Humans; Hypoxia; Immunosuppression Therapy; Immunosuppressive A

2023
Chronic Metformin Administration Does Not Alter Carotid Sinus Nerve Activity in Control Rats.
    Advances in experimental medicine and biology, 2023, Volume: 1427

    Topics: AMP-Activated Protein Kinases; Animals; Carotid Body; Carotid Sinus; Diabetes Mellitus, Type 2; Hype

2023
Effects of plateau hypoxia on population pharmacokinetics and pharmacodynamics of metformin in patients with Type 2 diabetes.
    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2023, Apr-28, Volume: 48, Issue:4

    Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Glucose; Humans; Hypoxia; Metformin; Tandem Mass Spectr

2023
Metformin Reduces Bone Resorption in Apical Periodontitis Through Regulation of Osteoblast and Osteoclast Differentiation.
    Journal of endodontics, 2023, Volume: 49, Issue:9

    Topics: Animals; Bone Resorption; Cell Differentiation; Core Binding Factor Alpha 1 Subunit; Hypoxia; Metfor

2023
Ultra-efficient radio-immunotherapy for reprogramming the hypoxic and immunosuppressive tumor microenvironment with durable innate immune memory.
    Biomaterials, 2023, Volume: 302

    Topics: Humans; Hypoxia; Immunosuppressive Agents; Immunotherapy; Manganese Compounds; Metformin; Neoplasms;

2023
Systemic hypoxia potentiates anti-tumor effects of metformin in hepatocellular carcinoma in mice.
    Acta biochimica et biophysica Sinica, 2020, Apr-20, Volume: 52, Issue:4

    Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Hypoxia; Liver Neoplasms; Male; Metformin; Mic

2020
Different effects of metformin and phenformin on hypoxia-induced Ca
    Brain research, 2021, 01-01, Volume: 1750

    Topics: Animals; Calcium; Cytosol; Hypoxia; Male; Metformin; Neurons; Phenformin; Primary Cell Culture; Rats

2021
Impact of hypoxia and AMPK on CFTR-mediated bicarbonate secretion in human cholangiocyte organoids.
    American journal of physiology. Gastrointestinal and liver physiology, 2021, 05-01, Volume: 320, Issue:5

    Topics: Adolescent; Anoctamin-1; Bicarbonates; Cell Survival; Cystic Fibrosis Transmembrane Conductance Regu

2021
Metformin Enhances the Effect of Regorafenib and Inhibits Recurrence and Metastasis of Hepatic Carcinoma After Liver Resection via Regulating Expression of Hypoxia Inducible Factors 2α (HIF-2α) and 30 kDa HIV Tat-Interacting Protein (TIP30).
    Medical science monitor : international medical journal of experimental and clinical research, 2018, Apr-14, Volume: 24

    Topics: Acetyltransferases; Animals; Apoptosis; Basic Helix-Loop-Helix Transcription Factors; Carcinoma, Hep

2018
Metformin attenuates renal medullary hypoxia in diabetic nephropathy through inhibition uncoupling protein-2.
    Diabetes/metabolism research and reviews, 2019, Volume: 35, Issue:2

    Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Hypoglycemic Agents; Hypoxia; Kidn

2019
Metformin administration prevents memory impairment induced by hypobaric hypoxia in rats.
    Behavioural brain research, 2019, 05-02, Volume: 363

    Topics: Animals; Apoptosis; Cognition; Hippocampus; Hypoxia; Male; Maze Learning; Memory Disorders; Metformi

2019
Metformin Prevents Progression of Experimental Pulmonary Hypertension via Inhibition of Autophagy and Activation of Adenosine Monophosphate-Activated Protein Kinase.
    Journal of vascular research, 2019, Volume: 56, Issue:3

    Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Autophagy-Related Proteins; Cells, Cultured; Dise

2019
Metformin as an adjuvant drug against pediatric sarcomas: hypoxia limits therapeutic effects of the drug.
    PloS one, 2013, Volume: 8, Issue:12

    Topics: Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosi

2013
Metformin attenuates blood-brain barrier disruption in mice following middle cerebral artery occlusion.
    Journal of neuroinflammation, 2014, Oct-15, Volume: 11

    Topics: AMP-Activated Protein Kinases; Animals; Blood-Brain Barrier; Brain Infarction; Cells, Cultured; Cyto

2014
Metformin suppresses hypoxia-induced stabilization of HIF-1α through reprogramming of oxygen metabolism in hepatocellular carcinoma.
    Oncotarget, 2016, Jan-05, Volume: 7, Issue:1

    Topics: AMP-Activated Protein Kinases; Animals; Blotting, Western; Carcinoma, Hepatocellular; Cell Hypoxia;

2016
Selective Tuberous Sclerosis Complex 1 Gene Deletion in Smooth Muscle Activates Mammalian Target of Rapamycin Signaling and Induces Pulmonary Hypertension.
    American journal of respiratory cell and molecular biology, 2016, Volume: 55, Issue:3

    Topics: Animals; Cell Proliferation; Cells, Cultured; Chronic Disease; Gene Deletion; Hyperplasia; Hypertens

2016
The role of metformin and resveratrol in the prevention of hypoxia-inducible factor 1α accumulation and fibrosis in hypoxic adipose tissue.
    British journal of pharmacology, 2016, Volume: 173, Issue:12

    Topics: 3T3-L1 Cells; Adipose Tissue; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Fibrosis;

2016
Tunneling nanotube formation is stimulated by hypoxia in ovarian cancer cells.
    Oncotarget, 2016, Jul-12, Volume: 7, Issue:28

    Topics: Antineoplastic Agents; Biological Transport; Cell Communication; Cell Line, Tumor; Cell Membrane; Co

2016
Metformin Protects H9C2 Cardiomyocytes from High-Glucose and Hypoxia/Reoxygenation Injury via Inhibition of Reactive Oxygen Species Generation and Inflammatory Responses: Role of AMPK and JNK.
    Journal of diabetes research, 2016, Volume: 2016

    Topics: AMP-Activated Protein Kinases; Animals; Anisomycin; Cell Survival; Cytokines; Electron Transport; Gl

2016
Metformin and resveratrol ameliorate muscle insulin resistance through preventing lipolysis and inflammation in hypoxic adipose tissue.
    Cellular signalling, 2016, Volume: 28, Issue:9

    Topics: 3T3-L1 Cells; Adipose Tissue; Administration, Oral; Animals; Cyclic AMP; Cyclic AMP-Dependent Protei

2016
Prognostic value of plasma lactate levels in a retrospective cohort presenting at a university hospital emergency department.
    BMJ open, 2017, 01-30, Volume: 7, Issue:1

    Topics: Aged; Aged, 80 and over; Comorbidity; Diabetes Mellitus; Emergency Service, Hospital; Female; Hospit

2017
Environmental and genetic preconditioning for long-term anoxia responses requires AMPK in Caenorhabditis elegans.
    PloS one, 2011, Feb-03, Volume: 6, Issue:2

    Topics: Adenylate Kinase; Animals; Caenorhabditis elegans; Dietary Carbohydrates; Environment; Escherichia c

2011
Endogenous insulin signaling protects cultured neurons from oxygen-glucose deprivation-induced cell death.
    Neuroscience, 2006, Nov-17, Volume: 143, Issue:1

    Topics: Animals; Blotting, Western; Cell Death; Cell Survival; Cells, Cultured; Dose-Response Relationship,

2006
Metformin-associated lactic acidosis in diabetic patients with acute renal failure. A critical analysis of its pathogenesis and prognosis.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1994, Volume: 9 Suppl 4

    Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Eryt

1994
Monotherapy with metformin: does it improve hypoxia in type 2 diabetic patients?
    Clinical chemistry and laboratory medicine, 2001, Volume: 39, Issue:9

    Topics: Antioxidants; Catalase; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Hypoxia; Mal

2001
[Reversible hyperlactatemia induced by phenformin with muscular asthenia and cardio-respiratory signs].
    La Presse medicale, 1970, Jan-03, Volume: 78, Issue:1

    Topics: Aged; Animals; Asthenia; Diabetes Complications; Diabetic Ketoacidosis; Dyspnea; Heart Diseases; Hep

1970
[Lactic acidosis and sugar diabetics].
    Helvetica medica acta, 1970, Volume: 35, Issue:5

    Topics: Alcoholism; Diabetic Ketoacidosis; Humans; Hypoxia; Lactates; Metformin; Phenformin; Starvation

1970