metformin has been researched along with Anovulation in 89 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Anovulation: Suspension or cessation of OVULATION in animals or humans with follicle-containing ovaries (OVARIAN FOLLICLE). Depending on the etiology, OVULATION may be induced with appropriate therapy.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare the effect of combined metformin and clomiphene citrate (CC) with laparoscopic ovarian diathermy (LOD) meant for ovulation induction in CC-resistant women with polycystic ovary syndrome (PCOS)." | 9.15 | Combined metformin and clomiphene citrate versus laparoscopic ovarian diathermy for ovulation induction in clomiphene-resistant women with polycystic ovary syndrome: a randomized controlled trial. ( Abu Hashim, H; El Lakany, N; Sherief, L, 2011) |
| "For women with BMI > 32 kg/m(2), clinical pregnancy and live birth rates were 22% (7/32) and 16% (5/32) with metformin, 15% (5/33) and 6% (2/33) with placebo." | 9.14 | PCOSMIC: a multi-centre randomized trial in women with PolyCystic Ovary Syndrome evaluating Metformin for Infertility with Clomiphene. ( Buckingham, KL; Falkiner, J; Farquhar, CM; Johnson, NP; Milsom, S; Okonkwo, QL; Singh, VP; Stewart, AW, 2010) |
| "Although metformin and CC are two effective first-line approaches for improving pregnancy rates in anovulatory PCOS women, CC is associated with higher rates of ovulation." | 9.14 | Comparison of metformin and clomiphene citrate therapy for induction of ovulation in the polycystic ovary syndrome. ( Api, M; Baran, S; Cetin, A; Goksedef, BP, 2010) |
| "To evaluate ovulation and pregnancy predictors in infertile polycystic ovary syndrome (PCOS) patients who received clomiphene citrate (CC) and metformin as first-line ovulation inductors." | 9.14 | Efficacy predictors for metformin and clomiphene citrate treatment in anovulatory infertile patients with polycystic ovary syndrome. ( Falbo, A; Orio, F; Palomba, S; Tolino, A; Zullo, F, 2009) |
| " To elucidate the dynamics of FSH, LH, prolactin (PRL), TSH and insulin secretion in women with polycystic ovarian syndrome (PCOS) treated with metformin (MET)." | 9.14 | Metformin administration was associated with a modification of LH, prolactin and insulin secretion dynamics in women with polycystic ovarian syndrome. ( Adamopoulos, DA; Antsaklis, A; Billa, E; Kapolla, N; Koukkou, E; Milingos, S; Nicopoulou, SC; Venaki, E, 2009) |
| "The purpose of this study was to compare the effectiveness of laparoscopic ovarian diathermy (LOD) vs clomiphene citrate (CC) plus metformin in infertile patients with CC-resistant polycystic ovary syndrome (PCOS)." | 9.14 | Laparoscopic ovarian diathermy vs clomiphene citrate plus metformin as second-line strategy for infertile anovulatory patients with polycystic ovary syndrome: a randomized controlled trial. ( Battista, L; Falbo, A; Orio, F; Palomba, S; Russo, T; Tolino, A; Venturella, R; Zullo, F, 2010) |
| "An RCT among newly diagnosed, therapy naive women with polycystic ovary syndrome (PCOS) showed no significant differences in ovulation rate, ongoing pregnancy rate or spontaneous abortion rate in favour of clomifene citrate plus metformin compared with clomifene citrate." | 9.13 | Does adding metformin to clomifene citrate lead to higher pregnancy rates in a subset of women with polycystic ovary syndrome? ( Bossuyt, PM; Korevaar, JC; Moll, E; van der Veen, F, 2008) |
| "The aim of the study was to compare in a clinical setting the efficacy of CC and metformin as first-line approaches for treating anovulation in infertile PCOS patients." | 9.12 | Clomiphene citrate versus metformin as first-line approach for the treatment of anovulation in infertile patients with polycystic ovary syndrome. ( Falbo, A; Orio, F; Palomba, S; Russo, T; Tolino, A; Zullo, F, 2007) |
| "To establish whether metformin has a significant action in reducing visceral fat and improving other metabolic parameters in women with polycystic ovary syndrome (PCOS)." | 9.12 | The effect of metformin on fat distribution and the metabolic syndrome in women with polycystic ovary syndrome--a randomised, double-blind, placebo-controlled trial. ( Acharya, U; Fox, B; Lord, J; Thomas, R; Wilkin, T, 2006) |
| "Metformin is successfully used in the treatment of cycle disorders and anovulation in women with polycystic ovary syndrome (PCOS)." | 9.12 | Early effects of metformin in women with polycystic ovary syndrome: a prospective randomized, double-blind, placebo-controlled trial. ( Eisenhardt, S; Germeyer, A; Hamann, A; Henschel, V; Schwarzmann, N; Strowitzki, T; von Wolff, M, 2006) |
| "Metformin has been shown to improve fertility in anovulatory patients with polycystic ovary syndrome (PCOS), inducing not only a high ovulation and pregnancy rate but also reducing the incidence of miscarriages." | 9.12 | Uterine effects of metformin administration in anovulatory women with polycystic ovary syndrome. ( Carmina, E; Cascella, T; Colao, A; Falbo, A; Manguso, F; Orio, F; Palomba, S; Russo, T; Tolino, A; Zullo, F, 2006) |
| "Although metformin has been shown to be effective in the treatment of anovulation in women with polycystic ovary syndrome (PCOS), clomiphene citrate (CC) is still considered to be the first-line drug to induce ovulation in these patients." | 9.11 | Prospective parallel randomized, double-blind, double-dummy controlled clinical trial comparing clomiphene citrate and metformin as the first-line treatment for ovulation induction in nonobese anovulatory women with polycystic ovary syndrome. ( Carmina, E; Cascella, T; Colao, A; Falbo, A; Manguso, F; Orio, F; Palomba, S; Russo, T; Tolino, A; Zullo, F, 2005) |
| " Although long-term treatment with metformin can increase Hcy levels in patients with type II diabetes mellitus or coronary heart disease, it is becoming an increasingly accepted and widespread medication in polycystic ovary syndrome (PCOS)." | 9.11 | Homocysteine levels in women with polycystic ovary syndrome treated with metformin versus rosiglitazone: a randomized study. ( Aslan, E; Bagis, T; Erkanli, S; Haydardedeoglu, B; Kilicdag, EB; Tarim, E; Zeyneloglu, HB, 2005) |
| " Insulin-sensitising agents such as metformin may be effective in treating PCOS-related anovulation." | 8.95 | Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility. ( Balen, AH; Morley, LC; Norman, RJ; Tang, T; Yasmin, E, 2017) |
| "In agreement with the previous review, metformin was associated with improved clinical pregnancy but there was no evidence that metformin improves live birth rates whether it is used alone or in combination with clomiphene, or when compared with clomiphene." | 8.88 | Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility. ( Balen, AH; Lord, JM; Norman, RJ; Tang, T; Yasmin, E, 2012) |
| "There are differences in opinion as to whether metformin should play a role in the primary treatment of anovulatory infertility for women with polycystic ovary syndrome (PCOS)." | 8.87 | Metformin is a reasonable first-line treatment option for non-obese women with infertility related to anovulatory polycystic ovary syndrome--a meta-analysis of randomised trials. ( Johnson, N, 2011) |
| "In agreement with the previous review, metformin is still of benefit in improving clinical pregnancy and ovulation rates." | 8.86 | Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility. ( Balen, AH; Lord, JM; Norman, RJ; Tang, T; Yasmin, E, 2010) |
| " metformin, or the combination of both drugs as first-line therapy in anovulatory polycystic ovary syndrome (PCOS) patients seeking pregnancy." | 8.85 | Clomiphene citrate, metformin or both as first-step approach in treating anovulatory infertility in patients with polycystic ovary syndrome (PCOS): a systematic review of head-to-head randomized controlled studies and meta-analysis. ( Nestler, JE; Orio, F; Palomba, S; Pasquali, R, 2009) |
| "Metformin is an effective treatment for anovulation in women with PCOS." | 8.82 | Insulin-sensitising drugs (metformin, troglitazone, rosiglitazone, pioglitazone, D-chiro-inositol) for polycystic ovary syndrome. ( Flight, IH; Lord, JM; Norman, RJ, 2003) |
| "Metformin has become an established treatment for women with polycystic ovary syndrome, although controversy remains as to how effective it is and in which populations it should be used." | 8.82 | Metformin in polycystic ovary syndrome. ( Lord, J; Wilkin, T, 2004) |
| "To study the involvement of microribonucleic acids (miRNAs) in the pathogenesis of chronic anovulation and mechanism of metformin treatment in polycystic ovary syndrome (PCOS)." | 8.31 | The role of circulating miRNAs in mechanism of action and prediction of therapeutic responses of metformin in polycystic ovarian syndrome. ( Chen, MJ; Chen, SU; Huang, CC; Huang, YS; Yang, PK; Yang, YS, 2023) |
| "To assess pregnancy outcome in anovulatory infertility patients diagnosed with polycystic ovary syndrome (PCOS) who were treated with metformin." | 7.71 | Pregnancies following use of metformin for ovulation induction in patients with polycystic ovary syndrome. ( Buster, JE; Carson, SA; Heard, MJ; Pierce, A, 2002) |
| "Twenty-nine patients with hyperinsulinemic anovulation were treated with metformin for 12 weeks." | 7.71 | [Effects of metformin on hyperinsulinemic anovulation]. ( Li, R; Lin, J; Zhou, J, 2001) |
| "Metformin co-treatment in a group of insulin-resistant, normogonadotrophic, anovulatory patients resulted in normalization of the endocrine profile and facilitated monofollicular development during the FSH induction of ovulation." | 6.71 | Does metformin modify ovarian responsiveness during exogenous FSH ovulation induction in normogonadotrophic anovulation? A placebo-controlled double-blind assessment. ( Eijkemans, MJ; Fauser, BC; Hohmann, FP; Laven, JS; van Santbrink, EJ, 2005) |
| "Metformin is an insulin sensitizer widely used for the treatment of patients affected by type 2 diabetes mellitus." | 6.45 | Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: a comprehensive review. ( Falbo, A; Orio, F; Palomba, S; Zullo, F, 2009) |
| "Insulin resistance is an important pathophysiological feature of the polycystic ovary syndrome (PCOS)." | 6.43 | Is metformin a primary ovulatory agent in patients with polycystic ovary syndrome? ( Cheang, KI; Nestler, JE; Sharma, ST, 2006) |
| "Metformin treatment after 6 and 12 months significantly reduced weight, BMI, waist circumference, insulin and HOMA-IR (p=0." | 5.39 | Evaluation of endocrine changes in women with the polycystic ovary syndrome during metformin treatment. ( Velija-Ašimi, Z, 2013) |
| " Additionally, novel cosmetic techniques like electrolysis, laser and use of topically applied eflornithine to tackle the most distressing feature of facial hirsutism associated with PCOS, non-pharmacological therapy like acupuncture and the role of herbal medicine in PCOS management have also been discussed." | 5.22 | Polycystic ovarian syndrome-current pharmacotherapy and clinical implications. ( Ali, T; Amin, F; Ara, R; Bader, GN; Kareem, O; Malik, A; Mir, SA; Rashid, R, 2022) |
| "To compare the effect of combined metformin and clomiphene citrate (CC) with laparoscopic ovarian diathermy (LOD) meant for ovulation induction in CC-resistant women with polycystic ovary syndrome (PCOS)." | 5.15 | Combined metformin and clomiphene citrate versus laparoscopic ovarian diathermy for ovulation induction in clomiphene-resistant women with polycystic ovary syndrome: a randomized controlled trial. ( Abu Hashim, H; El Lakany, N; Sherief, L, 2011) |
| " To elucidate the dynamics of FSH, LH, prolactin (PRL), TSH and insulin secretion in women with polycystic ovarian syndrome (PCOS) treated with metformin (MET)." | 5.14 | Metformin administration was associated with a modification of LH, prolactin and insulin secretion dynamics in women with polycystic ovarian syndrome. ( Adamopoulos, DA; Antsaklis, A; Billa, E; Kapolla, N; Koukkou, E; Milingos, S; Nicopoulou, SC; Venaki, E, 2009) |
| "Although metformin and CC are two effective first-line approaches for improving pregnancy rates in anovulatory PCOS women, CC is associated with higher rates of ovulation." | 5.14 | Comparison of metformin and clomiphene citrate therapy for induction of ovulation in the polycystic ovary syndrome. ( Api, M; Baran, S; Cetin, A; Goksedef, BP, 2010) |
| "For women with BMI > 32 kg/m(2), clinical pregnancy and live birth rates were 22% (7/32) and 16% (5/32) with metformin, 15% (5/33) and 6% (2/33) with placebo." | 5.14 | PCOSMIC: a multi-centre randomized trial in women with PolyCystic Ovary Syndrome evaluating Metformin for Infertility with Clomiphene. ( Buckingham, KL; Falkiner, J; Farquhar, CM; Johnson, NP; Milsom, S; Okonkwo, QL; Singh, VP; Stewart, AW, 2010) |
| "The purpose of this study was to compare the effectiveness of laparoscopic ovarian diathermy (LOD) vs clomiphene citrate (CC) plus metformin in infertile patients with CC-resistant polycystic ovary syndrome (PCOS)." | 5.14 | Laparoscopic ovarian diathermy vs clomiphene citrate plus metformin as second-line strategy for infertile anovulatory patients with polycystic ovary syndrome: a randomized controlled trial. ( Battista, L; Falbo, A; Orio, F; Palomba, S; Russo, T; Tolino, A; Venturella, R; Zullo, F, 2010) |
| "The aim of this study was to compare the effectiveness of myo-inositol (MYO) and metformin, in monotherapy or in association with recombinant follicle stimulating hormone (r-FSH), in the treatment of menstrual irregularities, chronic anovulation, and female infertility in patients with polycystic ovary syndrome (PCOS)." | 5.14 | Insulin sensitiser agents alone and in co-treatment with r-FSH for ovulation induction in PCOS women. ( Benedetto, V; Raffone, E; Rizzo, P, 2010) |
| "To evaluate ovulation and pregnancy predictors in infertile polycystic ovary syndrome (PCOS) patients who received clomiphene citrate (CC) and metformin as first-line ovulation inductors." | 5.14 | Efficacy predictors for metformin and clomiphene citrate treatment in anovulatory infertile patients with polycystic ovary syndrome. ( Falbo, A; Orio, F; Palomba, S; Tolino, A; Zullo, F, 2009) |
| "Both metformin and orlistat show a similar effect on weight loss, ovulation rates and androgen concentrations." | 5.14 | An RCT of metformin versus orlistat for the management of obese anovulatory women. ( Amer, S; Ledger, WL; Li, TC; Metwally, M, 2009) |
| "An RCT among newly diagnosed, therapy naive women with polycystic ovary syndrome (PCOS) showed no significant differences in ovulation rate, ongoing pregnancy rate or spontaneous abortion rate in favour of clomifene citrate plus metformin compared with clomifene citrate." | 5.13 | Does adding metformin to clomifene citrate lead to higher pregnancy rates in a subset of women with polycystic ovary syndrome? ( Bossuyt, PM; Korevaar, JC; Moll, E; van der Veen, F, 2008) |
| "To establish whether metformin has a significant action in reducing visceral fat and improving other metabolic parameters in women with polycystic ovary syndrome (PCOS)." | 5.12 | The effect of metformin on fat distribution and the metabolic syndrome in women with polycystic ovary syndrome--a randomised, double-blind, placebo-controlled trial. ( Acharya, U; Fox, B; Lord, J; Thomas, R; Wilkin, T, 2006) |
| "Metformin has been shown to improve fertility in anovulatory patients with polycystic ovary syndrome (PCOS), inducing not only a high ovulation and pregnancy rate but also reducing the incidence of miscarriages." | 5.12 | Uterine effects of metformin administration in anovulatory women with polycystic ovary syndrome. ( Carmina, E; Cascella, T; Colao, A; Falbo, A; Manguso, F; Orio, F; Palomba, S; Russo, T; Tolino, A; Zullo, F, 2006) |
| "The aim of the study was to compare in a clinical setting the efficacy of CC and metformin as first-line approaches for treating anovulation in infertile PCOS patients." | 5.12 | Clomiphene citrate versus metformin as first-line approach for the treatment of anovulation in infertile patients with polycystic ovary syndrome. ( Falbo, A; Orio, F; Palomba, S; Russo, T; Tolino, A; Zullo, F, 2007) |
| "Metformin is successfully used in the treatment of cycle disorders and anovulation in women with polycystic ovary syndrome (PCOS)." | 5.12 | Early effects of metformin in women with polycystic ovary syndrome: a prospective randomized, double-blind, placebo-controlled trial. ( Eisenhardt, S; Germeyer, A; Hamann, A; Henschel, V; Schwarzmann, N; Strowitzki, T; von Wolff, M, 2006) |
| " Clomiphene citrate has been standard therapy for ovulation induction in patients seeking pregnancy, but recent evidence suggests that insulin sensitizing agents such as metformin may also be effective." | 5.11 | Estimating live birth rates after ovulation induction in polycystic ovary syndrome: sample size calculations for the pregnancy in polycystic ovary syndrome trial. ( Hafley, G; Kunselman, AR; Legro, RS; Myers, ER; Nestler, JE; Silva, SG, 2005) |
| " Although long-term treatment with metformin can increase Hcy levels in patients with type II diabetes mellitus or coronary heart disease, it is becoming an increasingly accepted and widespread medication in polycystic ovary syndrome (PCOS)." | 5.11 | Homocysteine levels in women with polycystic ovary syndrome treated with metformin versus rosiglitazone: a randomized study. ( Aslan, E; Bagis, T; Erkanli, S; Haydardedeoglu, B; Kilicdag, EB; Tarim, E; Zeyneloglu, HB, 2005) |
| "Although metformin has been shown to be effective in the treatment of anovulation in women with polycystic ovary syndrome (PCOS), clomiphene citrate (CC) is still considered to be the first-line drug to induce ovulation in these patients." | 5.11 | Prospective parallel randomized, double-blind, double-dummy controlled clinical trial comparing clomiphene citrate and metformin as the first-line treatment for ovulation induction in nonobese anovulatory women with polycystic ovary syndrome. ( Carmina, E; Cascella, T; Colao, A; Falbo, A; Manguso, F; Orio, F; Palomba, S; Russo, T; Tolino, A; Zullo, F, 2005) |
| "Aim of this study was to compare the effects of metformin and a body weight reduction regimen using sibutramine on insulinemia, insulin sensitivity, and ovarian function in women with anovulatory cycles or infertility." | 5.11 | Metformin versus sibutramine in the treatment of hyperinsulinemia in chronically anovulating women. ( Dravecka, I; Kraus, V; Lazurova, I; Petrovicova, J, 2004) |
| " Insulin-sensitising agents such as metformin may be effective in treating PCOS-related anovulation." | 4.95 | Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility. ( Balen, AH; Morley, LC; Norman, RJ; Tang, T; Yasmin, E, 2017) |
| "In women with WHO group II anovulation, letrozole and the combination of clomiphene and metformin are superior to clomiphene alone in terms of pregnancy." | 4.95 | Treatment strategies for women with WHO group II anovulation: systematic review and network meta-analysis ( Bhattacharya, S; Costello, MF; Johnson, NP; Kim, BV; Legro, RS; Mol, BW; Ng, EH; Norman, RJ; van Wely, M; Wang, R; Zhang, H, 2017) |
| "In agreement with the previous review, metformin was associated with improved clinical pregnancy but there was no evidence that metformin improves live birth rates whether it is used alone or in combination with clomiphene, or when compared with clomiphene." | 4.88 | Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility. ( Balen, AH; Lord, JM; Norman, RJ; Tang, T; Yasmin, E, 2012) |
| " Obese women suffering from polycystic ovary syndrome may be first offered metformin for 3-4 months before the addition of clomiphene." | 4.88 | [Treatment of infertility]. ( Koivunen, R; Morin-Papunen, L, 2012) |
| "There are differences in opinion as to whether metformin should play a role in the primary treatment of anovulatory infertility for women with polycystic ovary syndrome (PCOS)." | 4.87 | Metformin is a reasonable first-line treatment option for non-obese women with infertility related to anovulatory polycystic ovary syndrome--a meta-analysis of randomised trials. ( Johnson, N, 2011) |
| "In agreement with the previous review, metformin is still of benefit in improving clinical pregnancy and ovulation rates." | 4.86 | Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility. ( Balen, AH; Lord, JM; Norman, RJ; Tang, T; Yasmin, E, 2010) |
| " metformin, or the combination of both drugs as first-line therapy in anovulatory polycystic ovary syndrome (PCOS) patients seeking pregnancy." | 4.85 | Clomiphene citrate, metformin or both as first-step approach in treating anovulatory infertility in patients with polycystic ovary syndrome (PCOS): a systematic review of head-to-head randomized controlled studies and meta-analysis. ( Nestler, JE; Orio, F; Palomba, S; Pasquali, R, 2009) |
| "Metformin is a common treatment for women who have insulin resistance manifesting as type 2 diabetes or polycystic ovarian syndrome (PCOS)." | 4.82 | Metformin in obstetric and gynecologic practice: a review. ( Boyle, J; McCarthy, EA; McLachlan, K; Permezel, M; Walker, SP, 2004) |
| "Metformin is an effective treatment for anovulation in women with PCOS." | 4.82 | Insulin-sensitising drugs (metformin, troglitazone, rosiglitazone, pioglitazone, D-chiro-inositol) for polycystic ovary syndrome. ( Flight, IH; Lord, JM; Norman, RJ, 2003) |
| "Metformin has become an established treatment for women with polycystic ovary syndrome, although controversy remains as to how effective it is and in which populations it should be used." | 4.82 | Metformin in polycystic ovary syndrome. ( Lord, J; Wilkin, T, 2004) |
| " Although no clinical trials over 6 months in duration have assessed the long-term efficacy of metformin use in adolescents, short-term trials have shown promising effects in lowering insulin secretion, improving insulin sensitivity, restoring normal menstrual cycles, and correcting lipid abnormalities." | 4.81 | Polycystic ovary syndrome in adolescents. ( Kent, SC; Legro, RS, 2002) |
| "To study the involvement of microribonucleic acids (miRNAs) in the pathogenesis of chronic anovulation and mechanism of metformin treatment in polycystic ovary syndrome (PCOS)." | 4.31 | The role of circulating miRNAs in mechanism of action and prediction of therapeutic responses of metformin in polycystic ovarian syndrome. ( Chen, MJ; Chen, SU; Huang, CC; Huang, YS; Yang, PK; Yang, YS, 2023) |
| "Metformin has failed to gain wide acceptance as a first-line treatment option for women with anovulatory infertility related to polycystic ovary syndrome." | 3.77 | Analysis of factors predicting success of metformin and clomiphene treatment for women with infertility owing to PCOS-related ovulation dysfunction in a randomised controlled trial. ( Bontekoe, S; Johnson, NP; Stewart, AW, 2011) |
| "The pregnancy in polycystic ovary syndrome (PPCOS) study was a prospective, multi-center, randomized clinical trial comparing three ovulation induction regimens: clomiphene citrate (CC), metformin and the combination of the two." | 3.76 | Decision trees for identifying predictors of treatment effectiveness in clinical trials and its application to ovulation in a study of women with polycystic ovary syndrome. ( Brzyski, RG; Casson, PR; Chen, X; Christman, GM; Coutifaris, C; Diamond, MP; Eisenberg, E; Huang, H; Krawetz, SA; Legro, RS; Santoro, N; Schlaff, WD; Zhang, H; Zhang, J; Zhang, L, 2010) |
| " There is no evidence-based schema for achieving pregnancy in women with PCOS, though lifestyle modification, clomiphene citrate, and metformin are the current front line therapies." | 3.74 | Pregnancy considerations in women with polycystic ovary syndrome. ( Legro, RS, 2007) |
| "Twenty-nine patients with hyperinsulinemic anovulation were treated with metformin for 12 weeks." | 3.71 | [Effects of metformin on hyperinsulinemic anovulation]. ( Li, R; Lin, J; Zhou, J, 2001) |
| "To assess pregnancy outcome in anovulatory infertility patients diagnosed with polycystic ovary syndrome (PCOS) who were treated with metformin." | 3.71 | Pregnancies following use of metformin for ovulation induction in patients with polycystic ovary syndrome. ( Buster, JE; Carson, SA; Heard, MJ; Pierce, A, 2002) |
| "Metformin treatment was well tolerated." | 2.70 | Sensitization to insulin induces ovulation in nonobese adolescents with anovulatory hyperandrogenism. ( de Zegher, F; Ferrer, A; Ibáñez, L; Marcos, MV; Rodriguez-Hierro, F; Valls, C, 2001) |
| "We hypothesized that dyslipidemia and anovulation in nonobese women with polycystic ovary syndrome are essentially secondary to the concerted effects of hyperandrogenism and insulin resistance." | 2.70 | Additive effects of insulin-sensitizing and anti-androgen treatment in young, nonobese women with hyperinsulinism, hyperandrogenism, dyslipidemia, and anovulation. ( De Zegher, F; Dunger, DB; Ferrer, A; Ibáñez, L; Ong, K; Valls, C, 2002) |
| "Polycystic ovary syndrome is recognized as the most common hormonal and metabolic disorder likely to affect women." | 2.52 | [Evidence-based therapy of polycystic ovarian syndrome]. ( Csenteri, OK; Gődény, S, 2015) |
| "Insulin resistance is prevalent in women with polycystic ovary syndrome (PCOS), and plays a critical pathophysiologic role in both the metabolic and reproductive complications of PCOS." | 2.52 | Polycystic ovary syndrome and insulin: our understanding in the past, present and future. ( Evans, WS; Mayer, SB; Nestler, JE, 2015) |
| "Polycystic ovarian syndrome is the major cause of anovulation and is generally associated with obesity." | 2.48 | Evaluation and treatment of anovulatory and unexplained infertility. ( Bates, GW; Propst, AM, 2012) |
| "Metformin was also associated with a significantly higher incidence of gastrointestinal disturbance, but no serious adverse effects were reported." | 2.45 | WITHDRAWN: Insulin-sensitising drugs for polycystic ovary syndrome. ( Balen, AH; Lord, JM; Norman, RJ; Tang, T; Yasmin, E, 2009) |
| "Metformin is an insulin sensitizer widely used for the treatment of patients affected by type 2 diabetes mellitus." | 2.45 | Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: a comprehensive review. ( Falbo, A; Orio, F; Palomba, S; Zullo, F, 2009) |
| "Polycystic ovarian syndrome is the commonest endocrine disorder of reproductive-age women." | 2.44 | Polycystic ovarian syndrome--prognosis and treatment outcomes. ( Hart, R, 2007) |
| "Hypogonadotropic anovulation is treated with exogenous gonadotropins, and little has changed in its management." | 2.43 | Ovulatory disorders and infertility. ( Urman, B; Yakin, K, 2006) |
| " Evidence for the long-term use of metformin to protect against adverse cardiovascular outcomes and for the use of metformin throughout pregnancy to reduce the risk of miscarriage, gestational diabetes, pre-eclampsia and fetal macrosomia is still lacking." | 2.43 | Polycystic ovarian syndrome--prognosis and outcomes. ( Hart, R; Norman, R, 2006) |
| "Insulin resistance is an important pathophysiological feature of the polycystic ovary syndrome (PCOS)." | 2.43 | Is metformin a primary ovulatory agent in patients with polycystic ovary syndrome? ( Cheang, KI; Nestler, JE; Sharma, ST, 2006) |
| "The mechanism of anovulation is uncertain but there is evidence that arrested antral follicle development is associated with the abnormal endocrine profile, in particular the interaction of insulin and LH on granulosa cell differentiation." | 2.43 | Infertility in polycystic ovary syndrome: focus on low-dose gonadotropin treatment. ( Franks, S; Gorry, A; White, DM, 2006) |
| "Insulin resistance is a central feature of polycystic ovary syndrome (PCOS)." | 2.42 | Should insulin-sensitizing drugs be used in the treatment of polycystic ovary syndrome? ( Cheang, KI; Nestler, JE, 2004) |
| " However, a significant proportion of women with PCOS fail to ovulate with the use of standard dosage of CC and are called CC-resistant PCOS." | 2.42 | Minireview: Up-date management of non responder to clomiphene citrate in polycystic ovary syndrome. ( Abd el-Aal, G; Abdel-Kareem, O; Amin, M; Maruo, T; Moriyama, T; Takekida, S, 2003) |
| "Metformin treatment after 6 and 12 months significantly reduced weight, BMI, waist circumference, insulin and HOMA-IR (p=0." | 1.39 | Evaluation of endocrine changes in women with the polycystic ovary syndrome during metformin treatment. ( Velija-Ašimi, Z, 2013) |
"Metformin treatment was accompanied by a drop in fasting insulin and serum androgens and by a less atherogenic lipid profile (all P | 1.31 | Anovulation in eumenorrheic, nonobese adolescent girls born small for gestational age: insulin sensitization induces ovulation, increases lean body mass, and reduces abdominal fat excess, dyslipidemia, and subclinical hyperandrogenism. ( De Zegher, F; Ferrer, A; Ibáñez, L; Marcos, MV; Potau, N; Rodriguez-Hierro, F, 2002) | |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (2.25) | 18.2507 |
| 2000's | 49 (55.06) | 29.6817 |
| 2010's | 35 (39.33) | 24.3611 |
| 2020's | 3 (3.37) | 2.80 |
| Authors | Studies |
|---|---|
| Rashid, R | 1 |
| Mir, SA | 1 |
| Kareem, O | 1 |
| Ali, T | 1 |
| Ara, R | 1 |
| Malik, A | 1 |
| Amin, F | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Independent and Additive Effects Of Micronutrients With Metformin In Patients With PCOS:A Double Blind Randomized Placebo Controlled Trial[NCT05653895] | 250 participants (Anticipated) | Interventional | 2022-12-07 | Recruiting | |||
| The Effects of Acetyl L--Carnitine and Myo/Chiro-Inositol on Improving Ovulation, Pregnancy Rate, Ovarian Function and Perceived Stress Response in Patients With PCOS[NCT05767515] | 120 participants (Anticipated) | Interventional | 2023-04-15 | Not yet recruiting | |||
| Pregnancy in Polycystic Ovary Syndrome: A 30 Week Double-Blind Randomized Trial of Clomiphene Citrate, Metformin XR, and Combined Clomiphene Citrate/Metformin XR For the Treatment of Infertility in Women With Polycystic Ovary Syndrome[NCT00068861] | Phase 3 | 678 participants | Interventional | 2002-11-30 | Completed | ||
| A Multicenter Randomized Trial of Personalized Acupuncture, Fixed Acupuncture, Letrozole and Placebo on Live Birth for Infertility in Women With Polycystic Ovary Syndrome[NCT03625531] | Phase 3 | 1,100 participants (Anticipated) | Interventional | 2018-08-13 | Recruiting | ||
| Follicular Synchronization in Polycystic Ovarian Syndrome Patients Undergoing Intracytoplasmatic Sperm Injection With Letrozole /Antagonist Protocol: A Randomized Controlled Trial[NCT04069117] | Phase 4 | 200 participants (Actual) | Interventional | 2019-08-01 | Completed | ||
| Effect of Myoinositol on Serum Asprosin Levels in PCOS Patients[NCT05951309] | 30 participants (Actual) | Interventional | 2021-09-01 | Completed | |||
| Effectiveness of the Combination Liraglutide and Metformin on Weight Loss, Metabolic - Endocrine Parameters and Pregnancy Rate in Women With Polycystic Ovarian Syndrome, Obesity and Infertility[NCT05952882] | Phase 3 | 188 participants (Anticipated) | Interventional | 2023-11-01 | Not yet recruiting | ||
| A Randomised Controlled Clinical Trial of Metformin Versus Orlistat for the Management of Obese Anovulatory Women.[NCT00292799] | 36 participants (Actual) | Interventional | 2006-02-28 | Completed | |||
| Is the Co-administration of Metformine and CC as Compared to Placebo and CC Superior to Induce Ovulation in PCOS Patients With a Confirmed insulin-resistant-a Double Blind Randomized Clinical Trial[NCT02523898] | Phase 2 | 388 participants (Anticipated) | Interventional | 2015-11-30 | Enrolling by invitation | ||
| [NCT01514942] | Phase 4 | 0 participants | Interventional | Completed | |||
| Multi-Centre Randomised Controlled Trial of the Effectiveness of Metformin and Clomiphene Citrate for Treating Anovulatory Infertility in Women With Polycystic Ovary Syndrome[NCT00795808] | Phase 4 | 171 participants (Actual) | Interventional | 2003-08-31 | Completed | ||
| Effects of Inositol Alone or Associated With Alpha-lipoic Acid in Polycystic Ovary Syndrome Treatment[NCT04881851] | 90 participants (Anticipated) | Interventional | 2015-05-07 | Recruiting | |||
| Clinical Metabolic and Endocrine Parameters in Response to Metformin and Lifestyle Intervention in Women With Polycystic Ovary Syndrome: A Phase 4 Randomized, Double- Blind and Placebo Control Trial[NCT00679679] | Phase 4 | 30 participants (Actual) | Interventional | 2003-01-31 | Completed | ||
| Clomiphene Citrate Versus Metformin as First-Line Approach for the Treatment of Anovulation in Infertile Patients With Polycystic Ovary Syndrome[NCT00471523] | Phase 4 | 80 participants (Actual) | Interventional | 2006-05-31 | Completed | ||
| Efficacy of Long- Versus Short-term Metformin Protocol in Infertile Anovulatory PCOS Patients[NCT00501904] | Phase 4 | 20 participants (Anticipated) | Interventional | 2012-04-30 | Recruiting | ||
| Comparison of Three Different Strategies for Treating Infertility in Anovulatory Women With Polycystic Ovary Syndrome: a Multicentre Randomized Controlled Clinical Trial[NCT00461643] | Phase 4 | 552 participants (Anticipated) | Interventional | 2007-01-31 | Recruiting | ||
| How Long Should First-line Treatment be Continued in Infertile PCOS Patients Who Ovulate Under Clomiphene Citrate? A Randomized Controlled Clinical Study.[NCT00501839] | Phase 4 | 0 participants (Actual) | Interventional | 2008-08-31 | Withdrawn | ||
| What is the Following Step to Improve Fertility in Infertile PCOS Patients Ovulating Under Clomiphene Citrate or Metformin? A Randomized Controlled Clinical Study.[NCT00502229] | Phase 4 | 0 participants (Actual) | Interventional | 2010-01-31 | Withdrawn | ||
| Laparoscopic Ovarian Diathermy or Metformin Plus Clomiphene Citrate Administration as Second-Line Treatment for Infertile Anovulatory Patients With Polycystic Ovary Syndrome: a Randomized Controlled Trial[NCT00558077] | Phase 4 | 50 participants (Actual) | Interventional | 2003-02-28 | Completed | ||
| Effects of Metformin on Fertility and Pregnancy in Women With Polycystic Ovary Syndrome: a Randomized, Prospective, Placebo-controlled Multicenter Study[NCT00994812] | Phase 3 | 326 participants (Actual) | Interventional | 2002-08-31 | Completed | ||
| Circulating Anti-mullerian Hormone as Predictor of Ovarian Response to Clomiphene Citrate in Women With Polycystic Ovary Syndrome[NCT03316469] | 40 participants (Anticipated) | Interventional | 2018-07-31 | Not yet recruiting | |||
| Clomiphene Citrate Co-treatment With Low Dose HP Urinary FSH vs. HP Urinary FSH Step-up Protocol for Clomiphene-citrate Resistant PCOS Anovulatory Infertility: Randomized Controlled Trial[NCT01212263] | 174 participants (Actual) | Interventional | 2010-01-31 | Completed | |||
| [NCT01626443] | Phase 4 | 46 participants (Actual) | Interventional | 2014-01-31 | Completed | ||
| The Effect of Acupuncture on Insulin Sensitivity of Women With Polycystic Ovary Syndrome and Insulin Resistance: a Randomized Controlled Trial[NCT02491333] | Phase 3 | 342 participants (Actual) | Interventional | 2015-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
44 reviews available for metformin and Anovulation
| Article | Year |
|---|---|
Polycystic ovarian syndrome-current pharmacotherapy and clinical implications.
Topics: Acupuncture; Anovulation; Eflornithine; Female; Herbal Medicine; Hirsutism; Humans; Hydroxymethylglu | 2022 |
Controversial association between polycystic ovary syndrome and breast cancer.
Topics: Androgens; Anovulation; Aromatase Inhibitors; Breast Neoplasms; Clomiphene; Contraceptives, Oral, Co | 2019 |
Therapeutic approach for metabolic disorders and infertility in women with PCOS.
Topics: Androgen Antagonists; Anovulation; Clomiphene; Contraceptives, Oral, Hormonal; Female; Gonadotropins | 2018 |
Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility.
Topics: Abortion, Spontaneous; Anovulation; Clomiphene; Female; Humans; Hypoglycemic Agents; Infertility, Fe | 2017 |
Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility.
Topics: Abortion, Spontaneous; Anovulation; Clomiphene; Female; Humans; Hypoglycemic Agents; Infertility, Fe | 2017 |
Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility.
Topics: Abortion, Spontaneous; Anovulation; Clomiphene; Female; Humans; Hypoglycemic Agents; Infertility, Fe | 2017 |
Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility.
Topics: Abortion, Spontaneous; Anovulation; Clomiphene; Female; Humans; Hypoglycemic Agents; Infertility, Fe | 2017 |
Polycystic ovary syndrome and insulin: our understanding in the past, present and future.
Topics: Androgens; Anovulation; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Female; Humans; Hypoglyc | 2015 |
[Polycystic ovary syndrome].
Topics: Androgen Antagonists; Anovulation; Combined Modality Therapy; Contraceptives, Oral, Hormonal; Diabet | 2015 |
[Evidence-based therapy of polycystic ovarian syndrome].
Topics: Amenorrhea; Androgen Antagonists; Anovulation; Anti-Obesity Agents; Chorionic Gonadotropin; Contrace | 2015 |
Treatment strategies for the infertile polycystic ovary syndrome patient.
Topics: Anovulation; Antineoplastic Agents; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, | 2015 |
Mono-ovulation in women with polycystic ovary syndrome: a clinical review on ovulation induction.
Topics: Adult; Anovulation; Body Weight; Clomiphene; Female; Fertility Agents, Female; Gonadotropins; Humans | 2016 |
The management of anovulatory infertility in women with polycystic ovary syndrome: an analysis of the evidence to support the development of global WHO guidance.
Topics: Anovulation; Aromatase Inhibitors; Clomiphene; Consensus; Female; Fertility Agents, Female; Fertiliz | 2016 |
Ovulation induction in polycystic ovary syndrome: Current options.
Topics: Anovulation; Anti-Obesity Agents; Aromatase Inhibitors; Bariatric Surgery; Clomiphene; Diet Therapy; | 2016 |
Treatment strategies for women with WHO group II anovulation: systematic review and network meta-analysis
Topics: Anovulation; Clomiphene; Drug Therapy, Combination; Female; Humans; Infertility, Female; Letrozole; | 2017 |
Clomiphene citrate, metformin or both as first-step approach in treating anovulatory infertility in patients with polycystic ovary syndrome (PCOS): a systematic review of head-to-head randomized controlled studies and meta-analysis.
Topics: Anovulation; Clomiphene; Drug Therapy, Combination; Female; Humans; Infertility, Female; Metformin; | 2009 |
Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: a comprehensive review.
Topics: Anovulation; Cardiovascular Diseases; Endometrial Neoplasms; Endometrium; Evidence-Based Medicine; F | 2009 |
Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: a comprehensive review.
Topics: Anovulation; Cardiovascular Diseases; Endometrial Neoplasms; Endometrium; Evidence-Based Medicine; F | 2009 |
Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: a comprehensive review.
Topics: Anovulation; Cardiovascular Diseases; Endometrial Neoplasms; Endometrium; Evidence-Based Medicine; F | 2009 |
Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: a comprehensive review.
Topics: Anovulation; Cardiovascular Diseases; Endometrial Neoplasms; Endometrium; Evidence-Based Medicine; F | 2009 |
WITHDRAWN: Insulin-sensitising drugs for polycystic ovary syndrome.
Topics: Anovulation; Chromans; Female; Humans; Hypoglycemic Agents; Inositol; Metformin; Ovulation Induction | 2009 |
The use of metformin in the management of polycystic ovary syndrome and associated anovulatory infertility: the current evidence.
Topics: Anovulation; Female; Humans; Hypoglycemic Agents; Infertility, Female; Metformin; Patient Selection; | 2009 |
Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility.
Topics: Anovulation; Clomiphene; Female; Humans; Hypoglycemic Agents; Inositol; Metformin; Ovulation Inducti | 2009 |
Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility.
Topics: Anovulation; Clomiphene; Female; Humans; Hypoglycemic Agents; Inositol; Insulin Resistance; Live Bir | 2010 |
Metformin is a reasonable first-line treatment option for non-obese women with infertility related to anovulatory polycystic ovary syndrome--a meta-analysis of randomised trials.
Topics: Anovulation; Body Mass Index; Clomiphene; Drug Therapy, Combination; Female; Humans; Infertility, Fe | 2011 |
Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility.
Topics: Anovulation; Clomiphene; Female; Humans; Hypoglycemic Agents; Infertility, Female; Inositol; Insulin | 2012 |
The treatment of infertility in polycystic ovary syndrome: a brief update.
Topics: Adult; Anovulation; Clomiphene; Evidence-Based Medicine; Female; Fertility Agents, Female; Gonadotro | 2012 |
[Treatment of infertility].
Topics: Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Female; Fertilization in Vi | 2012 |
Ovulation induction in the management of anovulatory polycystic ovary syndrome.
Topics: Anovulation; Aromatase Inhibitors; Clomiphene; Female; Gonadotropins; Humans; Hypoglycemic Agents; I | 2013 |
Evaluation and treatment of anovulatory and unexplained infertility.
Topics: Anovulation; Clomiphene; Diet; Evidence-Based Medicine; Exercise; Female; Fertility Agents, Female; | 2012 |
Advances in polycystic ovary syndrome treatment: metformin and ovarian diathermy.
Topics: Algorithms; Anovulation; Clomiphene; Combined Modality Therapy; Diathermy; Female; Humans; Hyperinsu | 2002 |
Insulin-sensitising drugs (metformin, troglitazone, rosiglitazone, pioglitazone, D-chiro-inositol) for polycystic ovary syndrome.
Topics: Anovulation; Chromans; Female; Humans; Hypoglycemic Agents; Inositol; Metformin; Ovulation Induction | 2003 |
Minireview: Up-date management of non responder to clomiphene citrate in polycystic ovary syndrome.
Topics: Anovulation; Chromans; Clomiphene; Drug Resistance; Drug Therapy, Combination; Female; Gynecologic S | 2003 |
Metformin in obstetric and gynecologic practice: a review.
Topics: Abortion, Spontaneous; Anovulation; Diabetes Mellitus, Type 2; Female; Gastrointestinal Tract; Human | 2004 |
Should insulin-sensitizing drugs be used in the treatment of polycystic ovary syndrome?
Topics: Abortion, Spontaneous; Anovulation; Clomiphene; Drug Therapy, Combination; Female; Humans; Hypoglyce | 2004 |
Review of nonsurgical and surgical treatment and the role of insulin-sensitizing agents in the management of infertile women with polycystic ovary syndrome.
Topics: Adult; Anovulation; Clomiphene; Drug Resistance; Electrocoagulation; Female; Fertility Agents, Femal | 2004 |
Metformin in polycystic ovary syndrome.
Topics: Anovulation; Body Weight; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; G | 2004 |
Patient-tailored conventional ovulation induction algorithms in anovulatory infertility.
Topics: Algorithms; Anovulation; Clomiphene; Electrocoagulation; Female; Fertilization in Vitro; Follicle St | 2005 |
Ovulatory disorders and infertility.
Topics: Anovulation; Clomiphene; Female; Fertility Agents, Female; Glucocorticoids; Gonadotropin-Releasing H | 2006 |
Polycystic ovarian syndrome--prognosis and outcomes.
Topics: Adolescent; Anovulation; Cardiovascular Diseases; Clomiphene; Contraceptives, Oral; Diabetes Mellitu | 2006 |
Is metformin a primary ovulatory agent in patients with polycystic ovary syndrome?
Topics: Anovulation; Clinical Trials as Topic; Female; Fertility Agents, Female; Humans; Infertility, Female | 2006 |
Infertility in polycystic ovary syndrome: focus on low-dose gonadotropin treatment.
Topics: Adult; Anovulation; Clomiphene; Female; Gonadotropins; Humans; Infertility, Female; Metformin; Ovula | 2006 |
Is metformin the treatment of choice for anovulation in polycystic ovary syndrome?
Topics: Anovulation; Female; Humans; Metformin; Overweight; Polycystic Ovary Syndrome; Risk Reduction Behavi | 2007 |
Managing anovulatory infertility and polycystic ovary syndrome.
Topics: Anovulation; Female; Humans; Hypoglycemic Agents; Infertility, Female; Metformin; Obesity; Ovulation | 2007 |
Polycystic ovarian syndrome--prognosis and treatment outcomes.
Topics: Anovulation; Cardiovascular Diseases; Combined Modality Therapy; Contraceptives, Oral; Diabetes Mell | 2007 |
Ovulation induction in polycystic ovary syndrome.
Topics: Adult; Anovulation; Aromatase Inhibitors; Body Mass Index; Clomiphene; Diathermy; Female; Fertility | 2008 |
Role of hyperinsulinemia in the pathogenesis of the polycystic ovary syndrome, and its clinical implications.
Topics: Adrenal Glands; Androgens; Anovulation; Chromans; Diazoxide; Female; Humans; Hyperinsulinism; Hypogl | 1997 |
Role of hyperinsulinemia in the pathogenesis of the polycystic ovary syndrome, and its clinical implications.
Topics: Adrenal Glands; Androgens; Anovulation; Chromans; Diazoxide; Female; Humans; Hyperinsulinism; Hypogl | 1997 |
Role of hyperinsulinemia in the pathogenesis of the polycystic ovary syndrome, and its clinical implications.
Topics: Adrenal Glands; Androgens; Anovulation; Chromans; Diazoxide; Female; Humans; Hyperinsulinism; Hypogl | 1997 |
Role of hyperinsulinemia in the pathogenesis of the polycystic ovary syndrome, and its clinical implications.
Topics: Adrenal Glands; Androgens; Anovulation; Chromans; Diazoxide; Female; Humans; Hyperinsulinism; Hypogl | 1997 |
[Diagnosis and treatment of polycystic ovary syndrome].
Topics: Anovulation; Clomiphene; Diagnosis, Differential; Female; Humans; Hyperinsulinism; Insulin Resistanc | 1999 |
Polycystic ovary syndrome in adolescents.
Topics: Adolescent; Anovulation; Diabetes Mellitus, Type 2; Diagnosis, Differential; Female; Glucose Intoler | 2002 |
Should patients with polycystic ovarian syndrome be treated with metformin? A note of cautious optimism.
Topics: Anovulation; Body Weight; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Female; Gastrointestin | 2002 |
23 trials available for metformin and Anovulation
22 other studies available for metformin and Anovulation
| Article | Year |
|---|---|
[PCOS - desire for children and pregnancy].
Topics: Anovulation; Child; Female; Humans; Hyperandrogenism; Life Style; Metformin; Polycystic Ovary Syndro | 2023 |
The role of circulating miRNAs in mechanism of action and prediction of therapeutic responses of metformin in polycystic ovarian syndrome.
Topics: Anovulation; Cohort Studies; Female; Humans; Metformin; MicroRNAs; Polycystic Ovary Syndrome | 2023 |
Re: Inositol treatment of anovulation in women with polycystic ovary syndrome: a meta-analysis of randomised trials.
Topics: Anovulation; Female; Humans; Hypoglycemic Agents; Inositol; Metformin; Polycystic Ovary Syndrome | 2018 |
Re: Inositol treatment of anovulation in women with polycystic ovary syndrome: a meta-analysis of randomised trials.
Topics: Anovulation; Clomiphene; Female; Humans; Inositol; Metformin; Polycystic Ovary Syndrome | 2018 |
Authors' reply re: Inositol treatment of anovulation in women with polycystic ovary syndrome: a meta-analysis of randomised trials.
Topics: Anovulation; Clomiphene; Female; Humans; Inositol; Metformin; Polycystic Ovary Syndrome | 2018 |
Ovarian 11β-hydroxysteroid dehydrogenase (11βHSD) activity is suppressed in women with anovulatory polycystic ovary syndrome (PCOS): apparent role for ovarian androgens.
Topics: 11-beta-Hydroxysteroid Dehydrogenases; Adult; Androgens; Anovulation; Cortisone; Dose-Response Relat | 2013 |
Evaluation of endocrine changes in women with the polycystic ovary syndrome during metformin treatment.
Topics: Adult; Anovulation; Anthropometry; Body Mass Index; Endocrine System; Estradiol; Female; Follicle St | 2013 |
AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS, AMERICAN COLLEGE OF ENDOCRINOLOGY, AND ANDROGEN EXCESS AND PCOS SOCIETY DISEASE STATE CLINICAL REVIEW: GUIDE TO THE BEST PRACTICES IN THE EVALUATION AND TREATMENT OF POLYCYSTIC OVARY SYNDROME--PART 1.
Topics: Adolescent; Alopecia; Androgen Antagonists; Androgens; Anovulation; Diagnostic Techniques, Endocrine | 2015 |
Reply: Metformin for women with hyperandrogenic anovulation.
Topics: Anovulation; Female; Hirsutism; Humans; Hypoglycemic Agents; Metformin; Polycystic Ovary Syndrome | 2016 |
Metformin for women with hyperandrogenic anovulation.
Topics: Anovulation; Female; Hirsutism; Humans; Hypoglycemic Agents; Metformin; Polycystic Ovary Syndrome | 2016 |
A reappraisal of the role of polycystic ovary syndrome in recurrent miscarriage.
Topics: Abortion, Habitual; Androgens; Anovulation; Female; Gonadotropins; Humans; Infertility, Female; Insu | 2008 |
Decision trees for identifying predictors of treatment effectiveness in clinical trials and its application to ovulation in a study of women with polycystic ovary syndrome.
Topics: Age Factors; Androgens; Anovulation; Body Mass Index; Clomiphene; Decision Trees; Drug Therapy, Comb | 2010 |
Analysis of factors predicting success of metformin and clomiphene treatment for women with infertility owing to PCOS-related ovulation dysfunction in a randomised controlled trial.
Topics: Anovulation; Body Mass Index; Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Fem | 2011 |
Anovulation in eumenorrheic, nonobese adolescent girls born small for gestational age: insulin sensitization induces ovulation, increases lean body mass, and reduces abdominal fat excess, dyslipidemia, and subclinical hyperandrogenism.
Topics: Abdomen; Adolescent; Anovulation; Body Composition; Female; Humans; Hyperandrogenism; Hyperlipidemia | 2002 |
Metformin: an advance in ovulation induction.
Topics: Adult; Anovulation; Clomiphene; Female; Fertility Agents, Female; Humans; Hypoglycemic Agents; Infer | 2005 |
Drugs for anovulatory infertility in polycystic ovary syndrome.
Topics: Anovulation; Clomiphene; Drug Resistance; Female; Fertility Agents, Female; Humans; Infertility, Fem | 2006 |
Ovulation induction in women with polycystic ovary syndrome.
Topics: Adult; Anovulation; Clomiphene; Diathermy; Drug Therapy, Combination; Female; Fertility Agents, Fema | 2006 |
Pregnancy considerations in women with polycystic ovary syndrome.
Topics: Abortion, Spontaneous; Anovulation; Aromatase Inhibitors; Clomiphene; Female; Fertility Agents, Fema | 2007 |
What is the best first-step therapeutic approach in treating anovulatory infertility in patients with polycystic ovary syndrome? Questions that are still unanswered.
Topics: Anovulation; Clomiphene; Female; Fertility Agents, Female; Humans; Hypoglycemic Agents; Infertility, | 2007 |
Ovulation disorders: Part II. Anovulation associated with normal estrogen.
Topics: Adrenal Hyperplasia, Congenital; Anovulation; Cervix Mucus; Clomiphene; Drug Therapy, Combination; E | 2007 |
[Effects of metformin on hyperinsulinemic anovulation].
Topics: Adult; Anovulation; Female; Humans; Hyperinsulinism; Hypoglycemic Agents; Metformin; Ovulation; Test | 2001 |
Pregnancies following use of metformin for ovulation induction in patients with polycystic ovary syndrome.
Topics: Adult; Anovulation; Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Female; Metfo | 2002 |