metformin has been researched along with Amyotrophic Lateral Sclerosis in 3 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin is an anti-type II diabetes drug that has anti-inflammatory and anti-oxidant properties, can bring about mitochondrial biogenesis and has been shown to attenuate pathology in mouse models of Huntington's disease and multiple sclerosis." | 1.37 | Metformin treatment has no beneficial effect in a dose-response survival study in the SOD1(G93A) mouse model of ALS and is harmful in female mice. ( Kaneb, HM; Rahmani-Kondori, N; Sharp, PS; Wells, DJ, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 2 (66.67) | 2.80 |
| Authors | Studies |
|---|---|
| Hu, N | 1 |
| Ji, H | 1 |
| Rosbash, M | 1 |
| Kaneb, HM | 1 |
| Sharp, PS | 1 |
| Rahmani-Kondori, N | 1 |
| Wells, DJ | 1 |
1 review available for metformin and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Medications on hypertension, hyperlipidemia, diabetes, and risk of amyotrophic lateral sclerosis: a systematic review and meta-analysis.
Topics: Adrenergic beta-Antagonists; Amyotrophic Lateral Sclerosis; Angiotensin-Converting Enzyme Inhibitors | 2022 |
2 other studies available for metformin and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Metformin treatment of the C9orf72 ALS/FTD mouse: Almost too good for words.
Topics: Amyotrophic Lateral Sclerosis; Animals; C9orf72 Protein; DNA Repeat Expansion; Frontotemporal Dement | 2020 |
Metformin treatment has no beneficial effect in a dose-response survival study in the SOD1(G93A) mouse model of ALS and is harmful in female mice.
Topics: Aging; Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Animals; Body Weight; Cell Count; Dis | 2011 |