metformin has been researched along with Alloxan Diabetes in 621 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
| Excerpt | Relevance | Reference |
|---|---|---|
| "It was suggested that metformin could impede the MC activation and airway resistance in the concomitant diabetic and asthmatic rats." | 8.31 | Metformin regulates the effects of IR and IGF-1R methylation on mast cell activation and airway reactivity in diabetic rats with asthma through miR-152-3p/DNMT1 axis. ( Feng, H; Fu, D; He, L; Huang, Y; Li, A; Li, J; Liu, Y; Zhao, H, 2023) |
| "Metformin can prevent hyperglycaemia-induced osteoporosis and decrease the bone fracture rate, but the mechanism has not been fully elucidated." | 8.31 | Metformin promotes osteogenic differentiation and prevents hyperglycaemia-induced osteoporosis by suppressing PPARγ expression. ( Lian, H; Shen, X; Wang, S; Xie, Y; Yan, S; Zheng, L, 2023) |
| "These findings show that metformin provides substantial protection against diabetic cardiomyopathy-induced ROS-p53 mediated fibrosis and dyslipidemia." | 8.31 | Metformin ameliorates ROS-p53-collagen axis of fibrosis and dyslipidemia in type 2 diabetes mellitus-induced left ventricular injury. ( Al-Ani, B; Al-Hashem, F; Alzamil, NM; Bin-Jaliah, I; Dawood, AF; Haidara, MA; Hewett, PW; Kamar, SS; Latif, NSA; Shatoor, AS, 2023) |
| " Don for potential anti-diabetic activity in the in vivo mouse model of alloxan-induced hyperglycemia." | 8.12 | Detailed approach toward the anti-hyperglycemic potential of Sterculia diversifolia G. Don against alloxan-induced in vivo hyperglycemia model. ( Achyut, A; Amir, Z; Amna, N; Fazle, R; Irfan, U; Shafiq Ur, R, 2022) |
| "Linagliptin and its combination with metformin successfully ameliorated diabetic osteoporosis in HFD-fed mice possibly through modulation of BMP-2 and sclerostin." | 8.12 | Linagliptin in Combination With Metformin Ameliorates Diabetic Osteoporosis Through Modulating BMP-2 and Sclerostin in the High-Fat Diet Fed C57BL/6 Mice. ( Nirwan, N; Vohora, D, 2022) |
| "To investigate the protective effects of metformin on the diabetic mice with cognitive impairment induced by the combination of streptozotocin (STZ) and isoflurane anesthesia." | 8.02 | Metformin improves cognitive impairment in diabetic mice induced by a combination of streptozotocin and isoflurane anesthesia. ( Li, P; Lv, Z; Zhang, J; Zhang, W; Zhao, L, 2021) |
| " Metformin (MET) is considered as the first-line therapy for type 2 diabetes patients, and may be especially beneficial in cases of diabetic retinopathy although the precise mechanisms of MET action are not fully elucidated." | 8.02 | Protective effect of metformin on rat diabetic retinopathy involves suppression of toll-like receptor 4/nuclear factor-k B expression and glutamate excitotoxicity. ( Alolayan, SO; Alomar, SY; Atef, H; El-Shafey, M; Elaskary, AA; Eldosoky, M; Elhawary, R; Elkazaz, AY; Gabr, AM; M Barakat, B; Mohamed, AS; Salih, MAK; Youssef, AM; Zaitone, SA, 2021) |
| "This study aimed at comparing the effects of metformin on tubulointerstitial fibrosis (TIF) in different stages of diabetic nephropathy (DN) in vivo and evaluating the mechanism in high glucose (HG)-treated renal tubular epithelial cells (RTECs) in vitro." | 8.02 | Metformin attenuates renal tubulointerstitial fibrosis via upgrading autophagy in the early stage of diabetic nephropathy. ( Shi, K; Sun, D; Sun, H; Wang, F; Zhang, C; Zhang, X; Zuo, B, 2021) |
| " We tested whether metformin can suppress aortic AGEs production and protect against aortic injuries (aortopathy) and hypertension in streptozotocin-induced type 2 diabetes mellitus (T2DM) animal model." | 7.91 | Metformin suppresses aortic ultrastrucural damage and hypertension induced by diabetes: a potential role of advanced glycation end products. ( Abdel Latif, NS; Al-Ani, B; Amin, SN; Bin-Jaliah, I; Dallak, M; Eid, RA; Haidara, MA, 2019) |
| "Metformin attenuates diabetes-induced renal medullary tissue hypoxia in an animal model of insulinopenic type 1 diabetes." | 7.91 | Metformin attenuates renal medullary hypoxia in diabetic nephropathy through inhibition uncoupling protein-2. ( Christensen, M; Gustafsson, H; Krag, SP; Nørregaard, R; Palm, F; Schiffer, TA, 2019) |
| "Metformin was found to protect against hyperglycemia-induced injury in osteoblasts, but the cellular mechanisms involved remain unclear." | 7.91 | Metformin alleviates hyperglycemia-induced apoptosis and differentiation suppression in osteoblasts through inhibiting the TLR4 signaling pathway. ( Shen, X; Xie, Y; Yan, S; Ye, J; Zheng, L, 2019) |
| "We found that metformin treatment can robustly ameliorate periodontal infection and tissue destruction and reduce blood glucose and serum IL-1β levels in mice with diabetic periodontitis." | 7.91 | Metformin ameliorates experimental diabetic periodontitis independently of mammalian target of rapamycin (mTOR) inhibition by reducing NIMA-related kinase 7 (Nek7) expression. ( Ding, Y; Ji, N; Wang, Q; Xia, S; Zhang, P; Zhou, X, 2019) |
| "We demonstrated that the potential protection of the combined use of linagliptin and metformin on VSMC remodeling through AMPK/Nox4 signal pathway, resulting in the improvement of neointima hyperplasia in diabetic rats." | 7.91 | Inhibition of neointima hyperplasia by the combined therapy of linagliptin and metformin via AMPK/Nox4 signaling in diabetic rats. ( Li, XX; Tai, GJ; Xu, M; Zhang, WX, 2019) |
| " The aim of the current work was to investigate the effect of metformin versus vitamin D (and also simultaneous administration) therapy in type 2 diabetic (T2D) rats on the state of the muscle and insulin sensitivity." | 7.88 | Synergistic actions of vitamin D and metformin on skeletal muscles and insulin resistance of type 2 diabetic rats. ( Amin, SN; Hassan, SS; Hussein, UK; Rashed, LA; Yassa, HD, 2018) |
| " The aim of present study was to investigate the therapeutic potentials of resveratrol (RSV) alone and/or in combination with vitamin-E (Vit-E) against hyperglycemia-induced modulations using experimentally alloxan-induced diabetic animal model." | 7.88 | Resveratrol regulates hyperglycemia-induced modulations in experimental diabetic animal model. ( Akash, MSH; Munawar, SM; Rehman, K; Saeed, K, 2018) |
| "The present investigation was designed to explore the effectiveness of pterostilbene (PT) on insulin resistance, metabolic syndrome and oxidative stress in fructose-fed insulin resistant rats." | 7.85 | Pterostilbene ameliorates insulin sensitivity, glycemic control and oxidative stress in fructose-fed diabetic rats. ( Kosuru, R; Singh, S, 2017) |
| " This study investigated the effects of scopoletin on hepatic steatosis and inflammation in a high-fat diet fed type 1 diabetic mice by comparison with metformin." | 7.85 | Scopoletin Supplementation Ameliorates Steatosis and Inflammation in Diabetic Mice. ( Cho, HW; Choi, MS; Choi, RY; Ham, JR; Kim, MJ; Lee, HI; Lee, J; Lee, MK; Park, SK; Seo, KI, 2017) |
| " The aim of this study is to investigate the effect of AA extract on oxidative stress and dyslipidemia in diabetic rats induced by alloxan." | 7.85 | Effect of hydroalcoholic Allium ampeloprasum extract on oxidative stress, diabetes mellitus and dyslipidemia in alloxan-induced diabetic rats. ( Heidarian, E; Kheiri, S; Rafieian-Kopaei, M; Rahimi-Madiseh, M, 2017) |
| "The purpose of this study was to determine the effects of metformin on dysfunctional retinas in obesity-induced type 2 diabetic mice." | 7.85 | The Effects of Metformin on Obesity-Induced Dysfunctional Retinas. ( Chang, JY; Chang, RC; Kim, AJ; Ko, GY; Ko, ML; Shi, L, 2017) |
| "Metformin treatment reduces cell proliferation and reduces wound healing in an animal model and affects clinical outcomes in diabetic foot ulcer patients." | 7.83 | Metformin Induces Cell Cycle Arrest, Reduced Proliferation, Wound Healing Impairment In Vivo and Is Associated to Clinical Outcomes in Diabetic Foot Ulcer Patients. ( Castañeda-Delgado, JE; Cervantes-Villagrana, AR; Enciso-Moreno, JA; Fernandez-Ruiz, JC; Hernandez-Correa, AC; Nava-Ramirez, HS; Ochoa-Gonzalez, F, 2016) |
| " The present study aimed to evaluate the comparative effects of sodium butyrate (NaB) and metformin on the glucose homeostasis, insulin-resistance, fat accumulation and dyslipidemia in type-2 diabetic rat." | 7.83 | Sodium butyrate reduces insulin-resistance, fat accumulation and dyslipidemia in type-2 diabetic rat: A comparative study with metformin. ( Jena, G; Khan, S, 2016) |
| " (MS) bark juice in diabetic gastroparesis and its effect on pharmacokinetic of metformin (MET)." | 7.83 | Influence of Musa sapientum L. on pharmacokinetic of metformin in diabetic gastroparesis. ( Darvhekar, V; Jyotishi, SG; Mazumder, PM; Shelke, PG; Tripathi, AS, 2016) |
| "This study aimed to investigate the role of MTP on lipid metabolism disorders in insulin-resistant rats and the potential mechanism through which metformin can improve lipid metabolism disorders." | 7.83 | Metformin improves lipid metabolism disorders through reducing the expression of microsomal triglyceride transfer protein in OLETF rats. ( Guo, X; Liu, J; Liu, L; Wang, N; Wu, Y; Zhang, J, 2016) |
| "Pregnant nondiabetic mice were administered metformin beginning on the first day of pregnancy." | 7.80 | Lack of metformin effect on mouse embryo AMPK activity: implications for metformin treatment during pregnancy. ( Lee, HY; Loeken, MR; Wei, D, 2014) |
| "Although lactic acidosis has been recognized as a potential hazard in biguanide therapy, this complication has been claimed to be extremely rare with dimethylbiguanide (DMBG) (metformin)." | 7.66 | Metformin-induced lactic acidosis: potentiation by ethanol. ( Dubas, TC; Johnson, WJ, 1981) |
| " Future clinical trials are necessary to study the nephroprotective effects of the combined treatment at a low dosage in patients with diabetes." | 6.44 | Dapagliflozin and metformin in combination ameliorates diabetic nephropathy by suppressing oxidative stress, inflammation, and apoptosis and activating autophagy in diabetic rats. ( Htun, KT; Jaikumkao, K; Kothan, S; Lungkaphin, A; Montha, N; Pengrattanachot, N; Phengpol, N; Promsan, S; Sriburee, S; Sutthasupha, P; Thongnak, L, 2024) |
| "Hydrogen is a novel medical gas with several properties, including anti-oxidative, anti-inflammatory, anti-apoptotic, anti-allergic, and energy metabolism stimulating properties." | 5.72 | Co-administration of hydrogen and metformin exerts cardioprotective effects by inhibiting pyroptosis and fibrosis in diabetic cardiomyopathy. ( Bai, J; Hong, X; Liu, J; Nie, C; Pan, S; Wang, B; Xi, S; Yang, W; Yu, M; Zou, R, 2022) |
| "Metformin alone reduced hyperinsulinemia and circulating c-reactive protein, but exacerbated nephropathy." | 5.72 | Rapamycin/metformin co-treatment normalizes insulin sensitivity and reduces complications of metabolic syndrome in type 2 diabetic mice. ( Calcutt, NA; Doty, R; Flurkey, K; Harrison, DE; Koza, RA; Reifsnyder, PC, 2022) |
| "Metformin was used as the standard antidiabetic drug." | 5.62 | Vanillin exerts therapeutic effects against hyperglycemia-altered glucose metabolism and purinergic activities in testicular tissues of diabetic rats. ( Erukainure, OL; Islam, MS; Olofinsan, KA; Salau, VF, 2021) |
| " We concluded that PD-CSNPs and PD ameliorate diabetic liver damage by modulating glucose transporter 2 expression, affecting the activity of carbohydrate metabolism enzymes, and suppressing oxidative stress and inflammation, PD-CSNPs being more efficient than PD, probably due to higher bioavailability and prolonged release." | 5.62 | Hepatoprotective Effects of Polydatin-Loaded Chitosan Nanoparticles in Diabetic Rats: Modulation of Glucose Metabolism, Oxidative Stress, and Inflammation Biomarkers. ( Abd El-Hameed, AM; Abd El-Twab, SM; Abdel-Moneim, A; El-Shahawy, AAG; Yousef, AI, 2021) |
| "Non-alcoholic fatty liver disease (NAFLD) is one of the primary causes of chronic liver disease and is closely linked to insulin resistance, type 2 diabetes mellitus (T2DM), and dyslipidemia." | 5.62 | Metformin in Combination with Malvidin Prevents Progression of Non-Alcoholic Fatty Liver Disease via Improving Lipid and Glucose Metabolisms, and Inhibiting Inflammation in Type 2 Diabetes Rats. ( Gu, X; Li, X; Zhang, C; Zhu, H; Zou, W, 2021) |
| "Metformin has been used to treat patients with type 2 diabetes mellitus (T2DM), and animal and clinical studies have reported therapeutic effects of metformin in Alzheimer's disease (AD)." | 5.62 | Metformin attenuates vascular pathology by increasing expression of insulin-degrading enzyme in a mixed model of cerebral amyloid angiopathy and type 2 diabetes mellitus. ( Ando, Y; Inoue, Y; Masuda, T; Misumi, Y; Ueda, M, 2021) |
| "This study evaluated the influence of type 2 diabetes mellitus on bone loss, bone repair and cytokine production in hyperglycemic rats, treated or not with metformin." | 5.56 | Impact of hyperglycemia and treatment with metformin on ligature-induced bone loss, bone repair and expression of bone metabolism transcription factors. ( Azarias, JS; Bastos, MF; Garcia, RP; Malta, FS; Miranda, TS; Ribeiro, GKDR; Shibli, JA, 2020) |
| "Comorbid type 2 diabetes poses a great challenge to the global control of tuberculosis." | 5.56 | Disparate Effects of Metformin on Mycobacterium tuberculosis Infection in Diabetic and Nondiabetic Mice. ( Govan, B; Hansen, K; Henning, L; Ketheesan, N; Kupz, A; Miranda-Hernandez, S; Rush, CM; Sathkumara, HD, 2020) |
| "Comorbid depression was induced by five inescapable foot-shocks (2mA, 2ms duration) at 10s intervals on days 1, 5, 7, and 10." | 5.46 | Metformin and ascorbic acid combination therapy ameliorates type 2 diabetes mellitus and comorbid depression in rats. ( Kumar, M; Nayak, PK; Shivavedi, N; Tej, GNVC, 2017) |
| "Thus far, the treatment of painful diabetic neuropathy remains unsatisfactory." | 5.42 | Metformin attenuates hyperalgesia and allodynia in rats with painful diabetic neuropathy induced by streptozotocin. ( Chen, Y; Liu, J; Ma, J; Wang, Q; Xiang, L; Yu, H, 2015) |
| " These results indicated that chronic administration of Met regulated pancreatic inflammation generation, ion and hormone homeostasis and improved β cell function of diabetic KKAy mice." | 5.40 | [Metformin ameliorates β-cell dysfunction by regulating inflammation production, ion and hormone homeostasis of pancreas in diabetic KKAy mice]. ( Hou, SC; Liu, Q; Liu, SN; Shen, ZF; Sun, SJ; Wang, Y, 2014) |
| "Treatment with metformin sensitized the impaired insulin actions and also prevented appearance of molecular and pathological characteristics observed in AD." | 5.37 | Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer's-like changes. ( Bisht, B; Dey, CS; Gupta, A, 2011) |
| "Of all drugs used in the treatment of Type 2 diabetes, the insulin sensitizers thiazolidinediones (e." | 5.36 | Gastroprotective effects of the insulin sensitizers rosiglitazone and metformin against indomethacin-induced gastric ulcers in Type 2 diabetic rats. ( Abdel-Gaber, SA; Ashour, OM; Fouad, AA; Morsy, MA, 2010) |
| "Metformin vs placebo treatment of diabetic pigs (twice 1." | 5.33 | Association of insulin resistance with hyperglycemia in streptozotocin-diabetic pigs: effects of metformin at isoenergetic feeding in a type 2-like diabetic pig model. ( Ackermans, M; Corbijn, H; Dekker, R; Koopmans, SJ; Mroz, Z; Sauerwein, H, 2006) |
| " Moreover, compared to diabetic untreated and metformin-treated animals, those treated with PAP1 had the lowest risk of developing the life-threatening arrhythmia Torsade de Pointes under cardiac challenge." | 4.31 | Kv1.3 Channel Blockade Improves Inflammatory Profile, Reduces Cardiac Electrical Remodeling, and Prevents Arrhythmia in Type 2 Diabetic Rats. ( Alquiza, A; Casis, O; Echeazarra, L; Fernández-López, V; Gallego, M; Rodríguez-de-Yurre, A; Zayas-Arrabal, J, 2023) |
| " The present study aimed to determine whether metformin exerts beneficial effects on metabolic and neurobehavioral outcomes in the streptozotocin (STZ)-induced T1D model and western diet (WD)-induced obesity model in male Swiss mice." | 4.31 | Metformin improves neurobehavioral impairments of streptozotocin-treated and western diet-fed mice: Beyond glucose-lowering effects. ( Barbosa, LADS; Barros, WM; Braga, SP; Bullich, S; Delanogare, E; Dos Santos, GJ; Guiard, BP; Kasprowicz, JN; Kraus, SI; Moreira, ELG, 2023) |
| "Twenty female pregnant rats were used, and they were divided into four groups of control (normal pregnancy), disease (diabetic untreated), metformin (received 200 mg/kg metformin dissolved in distilled water) and tBHQ groups (received 25 mg/kg tBHQ in 1% corn oil), respectively, with five rats in each group." | 4.31 | Tert-butylhydroquinone Mitigates Renal Dysfunction in Pregnant Diabetic Rats ( Li, J; Liu, H; Shang, L, 2023) |
| "It was suggested that metformin could impede the MC activation and airway resistance in the concomitant diabetic and asthmatic rats." | 4.31 | Metformin regulates the effects of IR and IGF-1R methylation on mast cell activation and airway reactivity in diabetic rats with asthma through miR-152-3p/DNMT1 axis. ( Feng, H; Fu, D; He, L; Huang, Y; Li, A; Li, J; Liu, Y; Zhao, H, 2023) |
| "Metformin can prevent hyperglycaemia-induced osteoporosis and decrease the bone fracture rate, but the mechanism has not been fully elucidated." | 4.31 | Metformin promotes osteogenic differentiation and prevents hyperglycaemia-induced osteoporosis by suppressing PPARγ expression. ( Lian, H; Shen, X; Wang, S; Xie, Y; Yan, S; Zheng, L, 2023) |
| "These findings show that metformin provides substantial protection against diabetic cardiomyopathy-induced ROS-p53 mediated fibrosis and dyslipidemia." | 4.31 | Metformin ameliorates ROS-p53-collagen axis of fibrosis and dyslipidemia in type 2 diabetes mellitus-induced left ventricular injury. ( Al-Ani, B; Al-Hashem, F; Alzamil, NM; Bin-Jaliah, I; Dawood, AF; Haidara, MA; Hewett, PW; Kamar, SS; Latif, NSA; Shatoor, AS, 2023) |
| " Don for potential anti-diabetic activity in the in vivo mouse model of alloxan-induced hyperglycemia." | 4.12 | Detailed approach toward the anti-hyperglycemic potential of Sterculia diversifolia G. Don against alloxan-induced in vivo hyperglycemia model. ( Achyut, A; Amir, Z; Amna, N; Fazle, R; Irfan, U; Shafiq Ur, R, 2022) |
| "Co-administration of metformin (250 mg/kg) with berberine (125 mg/kg) could not only further improve insulin sensitivity, but also demonstrate different alterations on gut microbial communities than that of their individual treatment in db/db mice." | 4.12 | Effects of combination treatment with metformin and berberine on hypoglycemic activity and gut microbiota modulation in db/db mice. ( Kong, APS; Li, D; Li, Z; Lyu, Y; Ming, X; Shaw, PC; Yuan, X; Zhang, C; Zhang, J; Zuo, Z, 2022) |
| "Linagliptin and its combination with metformin successfully ameliorated diabetic osteoporosis in HFD-fed mice possibly through modulation of BMP-2 and sclerostin." | 4.12 | Linagliptin in Combination With Metformin Ameliorates Diabetic Osteoporosis Through Modulating BMP-2 and Sclerostin in the High-Fat Diet Fed C57BL/6 Mice. ( Nirwan, N; Vohora, D, 2022) |
| " This study intends to examine the effects of sea buckthorn and metformin on body weight, water and feed intake, glycaemia, insulinemia, sorbitol accumulation and cataract development in Zucker diabetic fatty rats, which represent an animal model of type 2 Diabetes mellitus, as well as to characterize the individual content of bioactive substances and the antioxidant activity of sea buckthorn." | 4.12 | The consumption of sea buckthorn (Hippophae rhamnoides L.) effectively alleviates type 2 diabetes symptoms in spontaneous diabetic rats. ( Brindza, J; Capcarova, M; Dupak, R; Hrnkova, J; Ivanisova, E; Kalafova, A; Kovac, J; Prnova, MS; Schneidgenova, M; Simonova, N; Tokarova, K, 2022) |
| "We compared the efficacy of n3-polyunsaturated fatty acids (n3-PUFAs) and metformin in halting the progression of non-alcoholic fatty liver disease (NAFLD) developed in the milieu of insulin deficiency." | 4.12 | The hepatoprotective effects of n3-polyunsaturated fatty acids against non-alcoholic fatty liver disease in diabetic rats through the FOXO1/PPARα/GABARAPL1 signalling pathway. ( El-Mesery, A; Elmasry, K; Elsayed, HRH; Eraky, SM; Ramadan, NM, 2022) |
| "To investigate the protective effects of metformin on the diabetic mice with cognitive impairment induced by the combination of streptozotocin (STZ) and isoflurane anesthesia." | 4.02 | Metformin improves cognitive impairment in diabetic mice induced by a combination of streptozotocin and isoflurane anesthesia. ( Li, P; Lv, Z; Zhang, J; Zhang, W; Zhao, L, 2021) |
| "Treatment with the polyherbal mixture extract was more effective than the standard drugs (insulin and metformin) in the amelioration of hyperglycemia, hyperlipidemia, and histopathological changes of the pancreas, kidney and liver tissue." | 4.02 | Polyherbal mixture ameliorates hyperglycemia, hyperlipidemia and histopathological changes of pancreas, kidney and liver in a rat model of type 1 diabetes. ( Djordjević, L; Jugović, D; Jušković, M; Madić, V; Petrović, A; Stojanović, G; Vasiljević, P, 2021) |
| " Metformin (MET) is considered as the first-line therapy for type 2 diabetes patients, and may be especially beneficial in cases of diabetic retinopathy although the precise mechanisms of MET action are not fully elucidated." | 4.02 | Protective effect of metformin on rat diabetic retinopathy involves suppression of toll-like receptor 4/nuclear factor-k B expression and glutamate excitotoxicity. ( Alolayan, SO; Alomar, SY; Atef, H; El-Shafey, M; Elaskary, AA; Eldosoky, M; Elhawary, R; Elkazaz, AY; Gabr, AM; M Barakat, B; Mohamed, AS; Salih, MAK; Youssef, AM; Zaitone, SA, 2021) |
| "This study aimed at comparing the effects of metformin on tubulointerstitial fibrosis (TIF) in different stages of diabetic nephropathy (DN) in vivo and evaluating the mechanism in high glucose (HG)-treated renal tubular epithelial cells (RTECs) in vitro." | 4.02 | Metformin attenuates renal tubulointerstitial fibrosis via upgrading autophagy in the early stage of diabetic nephropathy. ( Shi, K; Sun, D; Sun, H; Wang, F; Zhang, C; Zhang, X; Zuo, B, 2021) |
| " The protective effect of metformin pretreatment against alterations to the articular cartilage ultrastructure induced by type 2 diabetes mellitus (T2DM) associated with the inhibition of oxidative stress and inflammation has not been investigated before." | 3.96 | Metformin pretreatment suppresses alterations to the articular cartilage ultrastructure and knee joint tissue damage secondary to type 2 diabetes mellitus in rats. ( Abdel Kader, DH; Al-Ani, B; Alzamil, N; Dawood, AF; Ebrahim, HA; Haidara, MA; Kamar, SS, 2020) |
| " We tested whether metformin can suppress aortic AGEs production and protect against aortic injuries (aortopathy) and hypertension in streptozotocin-induced type 2 diabetes mellitus (T2DM) animal model." | 3.91 | Metformin suppresses aortic ultrastrucural damage and hypertension induced by diabetes: a potential role of advanced glycation end products. ( Abdel Latif, NS; Al-Ani, B; Amin, SN; Bin-Jaliah, I; Dallak, M; Eid, RA; Haidara, MA, 2019) |
| " Therefore, we have tested whether the previously proven blood-brain barrier protective agent, probucol, can prevent blood-brain barrier breakdown and cognitive decline in a dietary-induced murine model of diabetic insulin resistance." | 3.91 | Probucol prevents blood-brain barrier dysfunction and cognitive decline in mice maintained on pro-diabetic diet. ( Al-Salami, H; Brook, E; Fimognari, N; Lam, V; Mamo, JC; Mooranian, A; Nesbit, M; Takechi, R, 2019) |
| "Metformin attenuates diabetes-induced renal medullary tissue hypoxia in an animal model of insulinopenic type 1 diabetes." | 3.91 | Metformin attenuates renal medullary hypoxia in diabetic nephropathy through inhibition uncoupling protein-2. ( Christensen, M; Gustafsson, H; Krag, SP; Nørregaard, R; Palm, F; Schiffer, TA, 2019) |
| "Metformin was found to protect against hyperglycemia-induced injury in osteoblasts, but the cellular mechanisms involved remain unclear." | 3.91 | Metformin alleviates hyperglycemia-induced apoptosis and differentiation suppression in osteoblasts through inhibiting the TLR4 signaling pathway. ( Shen, X; Xie, Y; Yan, S; Ye, J; Zheng, L, 2019) |
| "Diabetic mice underwent surgical intervention to induce hind limb ischemia and were treated with simvastatin, metformin, or a combination orally for 28 days and compared to diabetic and nondiabetic mice." | 3.91 | Imaging the Proangiogenic Effects of Cardiovascular Drugs in a Diabetic Model of Limb Ischemia. ( Bhakoo, KK; Boominathan, R; Chan, K; Cheng, P; Goggi, JL; Haslop, A; Robins, EG; Soh, V, 2019) |
| "We found that metformin treatment can robustly ameliorate periodontal infection and tissue destruction and reduce blood glucose and serum IL-1β levels in mice with diabetic periodontitis." | 3.91 | Metformin ameliorates experimental diabetic periodontitis independently of mammalian target of rapamycin (mTOR) inhibition by reducing NIMA-related kinase 7 (Nek7) expression. ( Ding, Y; Ji, N; Wang, Q; Xia, S; Zhang, P; Zhou, X, 2019) |
| "Insulin and metformin improve the quality of the skin in rats with diabetes and insulin resistance, by restoring the content of hyaluronic acid to the healthy skin level." | 3.91 | Selected elements of extracellular matrix of the skin in diabetes and insulin resistance. ( Car, H; Knaś, M; Niczyporuk, M, 2019) |
| "We demonstrated that the potential protection of the combined use of linagliptin and metformin on VSMC remodeling through AMPK/Nox4 signal pathway, resulting in the improvement of neointima hyperplasia in diabetic rats." | 3.91 | Inhibition of neointima hyperplasia by the combined therapy of linagliptin and metformin via AMPK/Nox4 signaling in diabetic rats. ( Li, XX; Tai, GJ; Xu, M; Zhang, WX, 2019) |
| " The aim of the current work was to investigate the effect of metformin versus vitamin D (and also simultaneous administration) therapy in type 2 diabetic (T2D) rats on the state of the muscle and insulin sensitivity." | 3.88 | Synergistic actions of vitamin D and metformin on skeletal muscles and insulin resistance of type 2 diabetic rats. ( Amin, SN; Hassan, SS; Hussein, UK; Rashed, LA; Yassa, HD, 2018) |
| " The aim of present study was to investigate the therapeutic potentials of resveratrol (RSV) alone and/or in combination with vitamin-E (Vit-E) against hyperglycemia-induced modulations using experimentally alloxan-induced diabetic animal model." | 3.88 | Resveratrol regulates hyperglycemia-induced modulations in experimental diabetic animal model. ( Akash, MSH; Munawar, SM; Rehman, K; Saeed, K, 2018) |
| "The present investigation was designed to explore the effectiveness of pterostilbene (PT) on insulin resistance, metabolic syndrome and oxidative stress in fructose-fed insulin resistant rats." | 3.85 | Pterostilbene ameliorates insulin sensitivity, glycemic control and oxidative stress in fructose-fed diabetic rats. ( Kosuru, R; Singh, S, 2017) |
| "Metformin treatment increased whole-body insulin sensitivity." | 3.85 | Metformin attenuates the TLR4 inflammatory pathway in skeletal muscle of diabetic rats. ( Barbosa, LN; Caixeta, DC; de Assis de Araújo, F; Deconte, SR; Espindola, FS; Peixoto, LG; Sabino-Silva, R; Teixeira, RR; Vilela, DD, 2017) |
| " This study investigated the effects of scopoletin on hepatic steatosis and inflammation in a high-fat diet fed type 1 diabetic mice by comparison with metformin." | 3.85 | Scopoletin Supplementation Ameliorates Steatosis and Inflammation in Diabetic Mice. ( Cho, HW; Choi, MS; Choi, RY; Ham, JR; Kim, MJ; Lee, HI; Lee, J; Lee, MK; Park, SK; Seo, KI, 2017) |
| " The aim of this study is to investigate the effect of AA extract on oxidative stress and dyslipidemia in diabetic rats induced by alloxan." | 3.85 | Effect of hydroalcoholic Allium ampeloprasum extract on oxidative stress, diabetes mellitus and dyslipidemia in alloxan-induced diabetic rats. ( Heidarian, E; Kheiri, S; Rafieian-Kopaei, M; Rahimi-Madiseh, M, 2017) |
| "The purpose of this study was to determine the effects of metformin on dysfunctional retinas in obesity-induced type 2 diabetic mice." | 3.85 | The Effects of Metformin on Obesity-Induced Dysfunctional Retinas. ( Chang, JY; Chang, RC; Kim, AJ; Ko, GY; Ko, ML; Shi, L, 2017) |
| "Metformin treatment reduces cell proliferation and reduces wound healing in an animal model and affects clinical outcomes in diabetic foot ulcer patients." | 3.83 | Metformin Induces Cell Cycle Arrest, Reduced Proliferation, Wound Healing Impairment In Vivo and Is Associated to Clinical Outcomes in Diabetic Foot Ulcer Patients. ( Castañeda-Delgado, JE; Cervantes-Villagrana, AR; Enciso-Moreno, JA; Fernandez-Ruiz, JC; Hernandez-Correa, AC; Nava-Ramirez, HS; Ochoa-Gonzalez, F, 2016) |
| "The guideline for the management of new-onset diabetes after transplantation recommends metformin (MET) as a first-line drug, and addition of a second-line drug is needed to better control of hyperglycemia." | 3.83 | Effects of addition of a dipeptidyl peptidase IV inhibitor to metformin on sirolimus-induced diabetes mellitus. ( Chung, BH; Jin, J; Jin, L; Lim, SW; Yang, CW, 2016) |
| " The present study aimed to evaluate the comparative effects of sodium butyrate (NaB) and metformin on the glucose homeostasis, insulin-resistance, fat accumulation and dyslipidemia in type-2 diabetic rat." | 3.83 | Sodium butyrate reduces insulin-resistance, fat accumulation and dyslipidemia in type-2 diabetic rat: A comparative study with metformin. ( Jena, G; Khan, S, 2016) |
| " (MS) bark juice in diabetic gastroparesis and its effect on pharmacokinetic of metformin (MET)." | 3.83 | Influence of Musa sapientum L. on pharmacokinetic of metformin in diabetic gastroparesis. ( Darvhekar, V; Jyotishi, SG; Mazumder, PM; Shelke, PG; Tripathi, AS, 2016) |
| "The methanol (MECR) and aqueous (AECR) extracts (200 and 400mg/kg body weight) were administered orally to normal and diabetic rats with Metformin and solvent control as comparison groups." | 3.83 | Antidiabetic effects of Cuscuta reflexa Roxb. in streptozotocin induced diabetic rats. ( Kar, DM; Maharana, L; Panigrahi, SK; Rath, D, 2016) |
| "This study aimed to investigate the role of MTP on lipid metabolism disorders in insulin-resistant rats and the potential mechanism through which metformin can improve lipid metabolism disorders." | 3.83 | Metformin improves lipid metabolism disorders through reducing the expression of microsomal triglyceride transfer protein in OLETF rats. ( Guo, X; Liu, J; Liu, L; Wang, N; Wu, Y; Zhang, J, 2016) |
| " Metformin, which is widely used in the treatment of diabetes, ameliorates insulin sensitivity." | 3.81 | Metformin suppresses diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-+Leprdb/+Leprdb mice. ( Baba, A; Kochi, T; Kubota, M; Moriwaki, H; Ohno, T; Shimizu, M; Shirakami, Y; Tanaka, T; Tsurumi, H, 2015) |
| "Pregnant nondiabetic mice were administered metformin beginning on the first day of pregnancy." | 3.80 | Lack of metformin effect on mouse embryo AMPK activity: implications for metformin treatment during pregnancy. ( Lee, HY; Loeken, MR; Wei, D, 2014) |
| "Here, we sought to compare the efficacy of combining exercise and metformin for the treatment of type 2 diabetes and nonalcoholic fatty liver disease (NAFLD) in hyperphagic, obese, type 2 diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats." | 3.80 | Combining metformin and aerobic exercise training in the treatment of type 2 diabetes and NAFLD in OLETF rats. ( Booth, FW; Crissey, JM; Fletcher, JA; Ibdah, JA; Kearney, ML; Laughlin, MH; Linden, MA; Meers, GM; Morris, EM; Rector, RS; Sowers, JR; Thyfault, JP, 2014) |
| "Metformin is commonly used as the first line of medication for the treatment of metabolic syndromes, such as obesity and type 2 diabetes (T2D)." | 3.80 | Effect of metformin on metabolic improvement and gut microbiota. ( Ko, G; Lee, H, 2014) |
| "Chronic metformin treatment improved the glycemic homeostasis in pre-diabetic MSG-rats, glucose intolerance, tissue insulin resistance, hyperinsulinemia and decreased the fat tissue accretion." | 3.80 | Protective effect of metformin against walker 256 tumor growth is not dependent on metabolism improvement. ( Agostinho, AR; Barella, LF; Beraldi, EJ; de Castro Prado, MA; de Oliveira, JC; de Sant'Anna, JR; de Souza, CO; de Souza, HM; Franco, CC; Gravena, C; Malta, A; Mathias, PC; Miranda, RA; Prates, KV; Tófolo, LP; Torrezan, R; Trombini, AB, 2014) |
| "Telmisartan acts beneficially against diabetes-induced inflammation and improves insulin resistance in pre-diabetes OLETF rats fed with HFD." | 3.79 | Angiotensin II receptor blocker telmisartan prevents new-onset diabetes in pre-diabetes OLETF rats on a high-fat diet: evidence of anti-diabetes action. ( Li, LY; Luo, R; Sun, LT; Tian, FS; Xiong, HL; Zhao, ZQ; Zheng, XL, 2013) |
| "Gemfibrozil is a PPAR-α ligand that inhibits the progression of atherosclerosis in insulin resistance type 2 diabetes mellitus (IR type 2 DM)." | 3.79 | Gemfibrozil and its combination with metformin on pleiotropic effect on IL-10 and adiponectin and anti-atherogenic treatment in insulin resistant type 2 diabetes mellitus rats. ( Kurmi, MK; Raikwar, SK; Sharma, AK; Srinivasan, BP, 2013) |
| "Clinical and experimental investigations demonstrated that metformin, a widely used anti-diabetic drug, exhibits cardioprotective properties against myocardial infarction." | 3.79 | Chronic metformin associated cardioprotection against infarction: not just a glucose lowering phenomenon. ( Hall, AR; Hausenloy, DJ; McLaughlin, CP; Mocanu, MM; Whittington, HJ; Yellon, DM, 2013) |
| " Furthermore, the body weight, liver glycogen formation, antioxidant substance (GSH) and antioxidant enzyme (SOD and GPX) levels increased evidently in diabetic mice treated with both ASP and metformin." | 3.78 | Anti-diabetic activities of Acanthopanax senticosus polysaccharide (ASP) in combination with metformin. ( Fu, G; Fu, J; Gao, B; Tu, Y; Yuan, J; Zhang, N; Zhang, Y, 2012) |
| "Aspirin is a kind of anti-inflammatory drug and may be used to reverse hyperglycemia, hyperinsulinemia, and dyslipidemia by improving insulin resistance." | 3.77 | Effect of aspirin on the expression of hepatocyte NF-κB and serum TNF-α in streptozotocin-induced type 2 diabetic rats. ( Han, F; Han, L; Sun, X; Wang, B; Yi, J, 2011) |
| " Six weeks following streptozotocin or saline injection, gastric ulcers were induced by serosal application of acetic acid." | 3.77 | Role of activation of 5'-adenosine monophosphate-activated protein kinase in gastric ulcer healing in diabetic rats. ( Baraka, AM; Deif, MM, 2011) |
| " We followed the spontaneous evolution of liver steatosis and tested the therapeutic usefulness of metformin and fenofibrate in a model of steatosis, the Zucker diabetic fatty (ZDF) rat." | 3.75 | Nonalcoholic hepatic steatosis in Zucker diabetic rats: spontaneous evolution and effects of metformin and fenofibrate. ( Abdallah, P; Basset, A; Beylot, M; del Carmine, P; Forcheron, F; Haffar, G, 2009) |
| "Baicalin had reduced the hyperglycemia-induced mitochondrial membrane damage, as well as enhanced the effects of metformin, as was observed in the results from the metformin and baicalin treated groups." | 3.75 | Baicalin reduces mitochondrial damage in streptozotocin-induced diabetic Wistar rats. ( Hsu, A; Huang, D; Tan, BK; Waisundara, VY, 2009) |
| "Although lactic acidosis has been recognized as a potential hazard in biguanide therapy, this complication has been claimed to be extremely rare with dimethylbiguanide (DMBG) (metformin)." | 3.66 | Metformin-induced lactic acidosis: potentiation by ethanol. ( Dubas, TC; Johnson, WJ, 1981) |
| "Metformin is a first-line antihyperglycemic agent that works mainly by regulating hepatic glucose production and peripheral insulin sensitivity." | 2.58 | A preclinical overview of metformin for the treatment of type 2 diabetes. ( Du, M; Wang, J; Xu, X; Zhao, T; Zhou, T, 2018) |
| " The purpose of this review is to compile information about anti-diabetic activity of ferulic acid in in vitro and in vivo models with special emphasis on activity of ferulic acid when combined with metformin." | 2.55 | Hybrid drug combination: Combination of ferulic acid and metformin as anti-diabetic therapy. ( Doble, M; Nankar, R; Prabhakar, PK, 2017) |
| " Future clinical trials are necessary to study the nephroprotective effects of the combined treatment at a low dosage in patients with diabetes." | 2.44 | Dapagliflozin and metformin in combination ameliorates diabetic nephropathy by suppressing oxidative stress, inflammation, and apoptosis and activating autophagy in diabetic rats. ( Htun, KT; Jaikumkao, K; Kothan, S; Lungkaphin, A; Montha, N; Pengrattanachot, N; Phengpol, N; Promsan, S; Sriburee, S; Sutthasupha, P; Thongnak, L, 2024) |
| "Metformin was used as the antidiabetic drug." | 1.91 | Ferulic acid mitigates diabetic cardiomyopathy via modulation of metabolic abnormalities in cardiac tissues of diabetic rats. ( Erukainure, OL; Ijomone, OK; Islam, MS; Msomi, NZ; Olofinsan, KA; Salau, VF, 2023) |
| "Metformin or exenatide treatment could prevent the degradation of insulin receptor substrate-1 protein by reducing the effect of suppressors of cytokine signaling-1 and suppressors of cytokine signaling-3 proteins, especially in the liver tissue." | 1.91 | Effects of antidiabetics and exercise therapy on suppressors of cytokine signaling-1, suppressors of cytokine signaling-3, and insulin receptor substrate-1 molecules in diabetes and obesity. ( Akarsu, E; Balcı, SO; Bozdag, Z; Demirel, C; Korkmaz, M; Sayiner, ZA; Yılmaz, I, 2023) |
| " Repaglinide with poor water solubility has relatively low oral bioavailability (56%) and undergoes hepatic first-pass metabolism." | 1.91 | In Vivo Evaluation of Nanoemulsion Formulations for Metformin and Repaglinide Alone and Combination. ( Bayram, C; Cetin, M; Hacimuftuoglu, A; Kaplan, ABU; Taghizadehghalehjoughi, A; Yildirim, S, 2023) |
| "Gastroparesis is a well-known consequence of long-standing diabetes that presents with gastric dysmotility in the absence of gastric outlet obstruction." | 1.91 | The role of mosapride and levosulpiride in gut function and glycemic control in diabetic rats. ( Akrab, SNA; Al Gawhary, NE; Morcos, GNB; Shafik, AN; Wissa, MY, 2023) |
| "Cirsimaritin is a dimethoxy flavon that has different biological activities such as antiproliferative, antimicrobial, and antioxidant activities." | 1.91 | The Emerging Importance of Cirsimaritin in Type 2 Diabetes Treatment. ( AbuDalo, R; Al-Hashimi, N; Alqudah, A; Alqudah, M; Alshaikh, HA; Athamneh, RY; Gammoh, O; Oqal, M; Qnais, E, 2023) |
| "Metformin is a first-line drug for the clinical treatment of type 2 diabetes; however, it always leads to gastrointestinal tolerance, low bioavailability, short half-life, etc." | 1.91 | A Novel Drug Delivery System: Hyodeoxycholic Acid-Modified Metformin Liposomes for Type 2 Diabetes Treatment. ( Chen, R; Chen, Y; Gou, T; Hu, M; Liu, J; Peng, C; Xu, M; Ye, Q; Zhou, T, 2023) |
| "Oral treatment of metformin with AG and FM in STZ-injected rats could ameliorate protective pathways and can be one of the promising oral anti-diabetic herbal agents." | 1.91 | Ameliorative effect of Arabic gum Acacia and mori extracts in streptozotocin-induced diabetic rats: implications of Cas-3 and TGF-β. ( Ali, HS; El-Adl, MA; El-Shafei, RA; Nomier, Y, 2023) |
| "Metformin treatment decreased hepatic SGK1 expression levels in db/db mice." | 1.91 | Role of serum- and glucocorticoid-inducible kinase 1 in the regulation of hepatic gluconeogenesis. ( Chen, J; Liu, Q; Shao, L; Sheng, C; Tan, J; Wang, S; Wang, X; Wang, Y; Xu, Z; Zhou, L, 2023) |
| "Metformin was found to protect the brain and cerebellum of STZ-induced diabetic rats with Dunning prostate cancer from harm caused by MAT-Lylu metastatic cells." | 1.91 | Oxidative brain and cerebellum injury in diabetes and prostate cancer model: Protective effect of metformin. ( Bulan, OK; Dagsuyu, E; Gul, IB; Koroglu, P; Yanardag, R, 2023) |
| "Treatment with rutin and metformin in combination significantly reduced PE-induced contraction and increased ACh-induced and SNP-induced relaxation in diabetes when compared to rutin or metformin alone." | 1.91 | Influence of rutin and its combination with metformin on vascular functions in type 1 diabetes. ( Chakravarthi, S; Chellian, J; David, SR; Lai, PPN; Rajabalaya, R, 2023) |
| "We aimed to evaluate whether pulmonary fibrosis occurs in type 2 diabetes rat models and whether VD3 can prevent it by inhibiting pyroptosis." | 1.91 | Vitamin D3 alleviates lung fibrosis of type 2 diabetic rats via SIRT3 mediated suppression of pyroptosis. ( Chen, H; Li, M; Li, W; Li, X; Peng, Y; Song, H; Tang, L; Zhang, D; Zhang, Y, 2023) |
| "Gallic acid is a type of phenolic acid that has been shown to be a potential drug candidate to treat diabetic kidney disease, an important complication of diabetes." | 1.91 | Gallic acid improves the metformin effects on diabetic kidney disease in mice. ( Hong, Y; Sun, W; Wang, J; Xu, X; Zhang, K; Zhang, L, 2023) |
| "Then, stroke was induced by transient middle cerebral artery occlusion (tMCAO)." | 1.72 | Effects of co-administration of metformin and evogliptin on cerebral infarct volume in the diabetic rat. ( Hong, JM; Joe, EH; Lee, JS; Lee, SJ; Yoon, BS, 2022) |
| "Metformin has a more profound effect than the plant extracts; however, cinnamon has a comparable effect." | 1.72 | Mitigation of streptozotocin-induced alterations by natural agents via upregulation of PDX1 and Ins1 genes in male rats. ( Abd El Aziz, SA; Abdelgawad, HM; Abo Zeid, SM; Shehata, NI, 2022) |
| "Hydrogen is a novel medical gas with several properties, including anti-oxidative, anti-inflammatory, anti-apoptotic, anti-allergic, and energy metabolism stimulating properties." | 1.72 | Co-administration of hydrogen and metformin exerts cardioprotective effects by inhibiting pyroptosis and fibrosis in diabetic cardiomyopathy. ( Bai, J; Hong, X; Liu, J; Nie, C; Pan, S; Wang, B; Xi, S; Yang, W; Yu, M; Zou, R, 2022) |
| "When metformin was offered as a treatment for alloxan-induced diabetic animals, it caused a significant decline in Glc, TCH, TGs, LDL, and VLDL levels with significant elevation in GSH and without a significant change in HDL and MDA." | 1.72 | Evaluation of metformin performance on alloxan-induced diabetic rabbits. ( Hashim, WS; Qader, SM; Yasin, YS, 2022) |
| "Nonalcoholic fatty liver disease (NAFLD) is a common cause of clinical liver dysfunction and an important prepathological change of liver cirrhosis." | 1.72 | Efficacy of Sitagliptin on Nonalcoholic Fatty Liver Disease in High-fat-diet-fed Diabetic Mice. ( Cui, W; Kong, L; Yang, X; Zhou, ST, 2022) |
| "Alzheimer's disease is the most common cause of dementia in the elderly population." | 1.72 | Effects of antidiabetic agents on Alzheimer's disease biomarkers in experimentally induced hyperglycemic rat model by streptozocin. ( Ali, RH; Ali, SK, 2022) |
| "Metformin alone reduced hyperinsulinemia and circulating c-reactive protein, but exacerbated nephropathy." | 1.72 | Rapamycin/metformin co-treatment normalizes insulin sensitivity and reduces complications of metabolic syndrome in type 2 diabetic mice. ( Calcutt, NA; Doty, R; Flurkey, K; Harrison, DE; Koza, RA; Reifsnyder, PC, 2022) |
| "Morphine is a drug of choice for the treatment of severe and chronic pain, but tolerance to the antinociceptive effect limits its use." | 1.72 | Metformin prevents morphine-induced apoptosis in rats with diabetic neuropathy: a possible mechanism for attenuating morphine tolerance. ( Avci, O; Gursoy, S; Inan, ZDS; Ozdemir, E; Taskiran, AS, 2022) |
| "Metformin was used as the positive control." | 1.72 | Cinnamic acid is beneficial to diabetic cardiomyopathy via its cardioprotective, anti-inflammatory, anti-dyslipidemia, and antidiabetic properties. ( Nair, A; Preetha Rani, MR; Raghu, KG; Rajankutty, K; Ranjit, S; Salin Raj, P, 2022) |
| "Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2DM) commonly coexist and act synergistically to drive adverse clinical outcomes." | 1.72 | Exercise and Metformin Intervention Prevents Lipotoxicity-Induced Hepatocyte Apoptosis by Alleviating Oxidative and ER Stress and Activating the AMPK/Nrf2/HO-1 Signaling Pathway in db/db Mice. ( Cheng, S; Liu, J; Liu, X; Liu, Y; Lu, J; Tang, Q; Xiang, M; Yuan, X; Zhang, L; Zhang, Y; Zhu, S, 2022) |
| " The similar modes of action of puerarin and metformin in diabetic models suggest their positive pharmacodynamic interactions." | 1.72 | Pharmacodynamic Interactions between Puerarin and Metformin in Type-2 Diabetic Rats. ( Dai, L; Gao, P; Li, Z; Mo, Y; Wang, S; Wang, X; Zhang, S; Zhao, D, 2022) |
| "Metformin is a biguanide that exhibits antidiabetic, anticarcinogenic, and anti-inflammatory properties." | 1.72 | High Throughput Study for Molecular Mechanism of Metformin Pre-Diabetic Protection via Microarray Approach. ( Al Shhab, MA; Alrawashdeh, AY; Zihlif, MA, 2022) |
| "Metformin was administered for 14 days after diabetes and prostate cancer induced." | 1.72 | Brain Boron Level, DNA Content, and Myeloperoxidase Activity of Metformin-Treated Rats in Diabetes and Prostate Cancer Model. ( Aydın, PK; Bugan, I; Bulan, OK; Dagsuyu, E; Ozel, AB; Yanardag, R; Yarat, A, 2022) |
| "Neuropathic pain is a common complication of diabetes mellitus with poorly relieved by conventional analgesics." | 1.62 | Metformin attenuates diabetic neuropathic pain via AMPK/NF-κB signaling pathway in dorsal root ganglion of diabetic rats. ( Cao, XJ; Chen, X; Qian, HY; Sun, YZ; Wu, R; Xu, GY; Zhang, PA; Zhu, HY, 2021) |
| "Metformin was administered in the drinking water (200 mg/kg/d) for 24 weeks." | 1.62 | AMPK agonist alleviate renal tubulointerstitial fibrosis via activating mitophagy in high fat and streptozotocin induced diabetic mice. ( Han, YC; Li, AM; Liu, YT; Peng, CH; Song, N; Tang, SQ; Wu, XQ; Yang, M; Yang, S; Zhan, M; Zhang, H; Zhang, W, 2021) |
| "Metformin could inhibit the growth of tumor under the condition of diabetes and play a role in the intestinal homeostasis in mice." | 1.62 | Metformin inhibits tumor growth and affects intestinal flora in diabetic tumor-bearing mice. ( Chen, C; Gao, X; Kang, J; Li, C; Liu, Z; Luo, D, 2021) |
| "Sorbitan monostearate is a surfactant used in the food industry." | 1.62 | An Industrial Procedure for Pharmacodynamic Improvement of Metformin HCl via Granulation with Its Paracellular Pathway Enhancer Using Factorial Experimental Design. ( Al-Shoubki, AA; Donia, AA; Mady, OY, 2021) |
| "Metformin/donepezil were used to treat streptozotocin (STZ)-induced diabetic mice models." | 1.62 | The protective effect of Metformin/Donepezil in diabetic mice brain: evidence from bioinformatics analysis and experiments. ( Hou, Y; Li, FZ, 2021) |
| " Poor absorption and less bioavailability also impede the acceptance of PHF." | 1.62 | Development and characterization of spheroidal antidiabetic polyherbal formulation from fresh vegetable juice: A novel approach. ( Gauttam, VK; Kalia, AN; Mukhija, M; Rath, G; Virk, JK, 2021) |
| "Dunning prostate cancer was induced in Copenhagen rats using high metastatic MAT-LyLu cells." | 1.62 | Metformin protects against diabetes-induced heart injury and dunning prostate cancer model. ( Bayrak, BB; Karabulut Bulan, O; Koroglu, P; Yanardag, R, 2021) |
| "Metformin treatment altered the metabolomics profiles of diabetic rats and lowered their blood sugar levels." | 1.62 | The effects of high-fat diet and metformin on urinary metabolites in diabetes and prediabetes rat models. ( Gam, LH; Greimel, P; Ibrahim, B; Ismail, MN; Lee, YF; Murugaiyah, V; Sim, XY; Teh, YH, 2021) |
| "Repaglinide and metformin were complexed with amberlite resin; later resin complexed drug was encapsulated in Ethylcellulose floating microspheres." | 1.62 | Repaglinide and Metformin-Loaded Amberlite Resin-Based Floating Microspheres for the Effective Management of Type 2 Diabetes. ( Jain, AK; Jain, SK; Mishra, K; Sahu, P, 2021) |
| "Metformin and insulin were used for therapy; the resulting changes to glycogen metabolism and embryo implantation were examined." | 1.62 | The Effects of Altered Endometrial Glucose Homeostasis on Embryo Implantation in Type 2 Diabetic Mice. ( Cui, ZH; Guo, WJ; Ma, YD; Nie, L; Wang, YC; Yuan, DZ; Yue, LM; Zhang, JH; Zhang, LX; Zhang, XQ; Zhao, D, 2021) |
| "This study was designed to investigate the efficacy and underlying mechanisms of HKC combined with metformin (MET), the first-line medication for treating type 2 diabetes, in the treatment of renal interstitial fibrosis." | 1.62 | Huangkui capsule in combination with metformin ameliorates diabetic nephropathy via the Klotho/TGF-β1/p38MAPK signaling pathway. ( Gu, LY; Tang, HT; Xu, ZX, 2021) |
| "Empagliflozin treatment was more effective than metformin alone, with a combination of the two drugs demonstrating the greatest effects." | 1.62 | SGLT2-i improves markers of islet endothelial cell function in db/db diabetic mice. ( Aplin, AC; Castillo, JJ; Esser, N; Hackney, DJ; Hogan, MF; Hull, RL; Larmore, MJ; Mundinger, TO; Zraika, S, 2021) |
| "Metformin is an AMP kinase (AMPK) activator, the widest used antidiabetic drug." | 1.62 | Metformin impairs homing ability and efficacy of mesenchymal stem cells for cardiac repair in streptozotocin-induced diabetic cardiomyopathy in rats. ( Ammar, HI; Ashour, H; Dhingra, S; Fadel, M; Kamar, SS; Rashed, LA; Shamseldeen, AM; Shoukry, HS; Srivastava, A, 2021) |
| "Berberine was used to uncover the mechanisms for the treatment of hyperinsulinemia in IR model." | 1.62 | Berberine ameliorates neuronal AD-like change via activating Pi3k/PGCε pathway. ( Bao, Y; Chen, Q; Han, Y; Liu, C; Liu, W; Liu, X; Wang, J; Wu, N; Ye, Y; Yu, Y, 2021) |
| "Metformin was used as the standard antidiabetic drug." | 1.62 | Vanillin exerts therapeutic effects against hyperglycemia-altered glucose metabolism and purinergic activities in testicular tissues of diabetic rats. ( Erukainure, OL; Islam, MS; Olofinsan, KA; Salau, VF, 2021) |
| " We concluded that PD-CSNPs and PD ameliorate diabetic liver damage by modulating glucose transporter 2 expression, affecting the activity of carbohydrate metabolism enzymes, and suppressing oxidative stress and inflammation, PD-CSNPs being more efficient than PD, probably due to higher bioavailability and prolonged release." | 1.62 | Hepatoprotective Effects of Polydatin-Loaded Chitosan Nanoparticles in Diabetic Rats: Modulation of Glucose Metabolism, Oxidative Stress, and Inflammation Biomarkers. ( Abd El-Hameed, AM; Abd El-Twab, SM; Abdel-Moneim, A; El-Shahawy, AAG; Yousef, AI, 2021) |
| "Metformin (50 mg/kg bw) was used as a standard drug." | 1.62 | Swietenine potentiates the antihyperglycemic and antioxidant activity of Metformin in Streptozotocin induced diabetic rats. ( Balijepalli, MK; Chakravarthi, S; Mak, KK; Pichika, MR; Shiming, Z, 2021) |
| " This study is designed to explore the therapeutic potential of metformin and montelukast, in combination with Lactobacillus, for modulation of intestinal flora and suppression of oxidative stress in testicular and liver damage in diabetic male rats." | 1.62 | The therapeutic role of lactobacillus and montelukast in combination with metformin in diabetes mellitus complications through modulation of gut microbiota and suppression of oxidative stress. ( El-Baz, AM; El-Sokkary, MMA; Hassan, HM; Khodir, AE; Shata, A, 2021) |
| "Metformin treatment was applied by gavage every day." | 1.62 | Histological and biochemical investigation of the renoprotective effects of metformin in diabetic and prostate cancer model. ( Bayrak, BB; Bugan, I; Karabulut-Bulan, O; Koroglu-Aydın, P; Yanardag, R, 2021) |
| "Metformin treatment of the diabetic/obese mice effectively normalized glucose levels, reconfigured the mammary tumor milieu, and decreased metastatic seeding." | 1.62 | Normalizing glucose levels reconfigures the mammary tumor immune and metabolic microenvironment and decreases metastatic seeding. ( Alsheikh, HAM; Ha, CM; Hinshaw, DC; Kammerud, SC; Lama-Sherpa, T; Metge, BJ; Mota, MSV; Samant, RS; Sharafeldin, N; Shevde, LA; Wende, AR, 2021) |
| "Non-alcoholic fatty liver disease (NAFLD) is one of the primary causes of chronic liver disease and is closely linked to insulin resistance, type 2 diabetes mellitus (T2DM), and dyslipidemia." | 1.62 | Metformin in Combination with Malvidin Prevents Progression of Non-Alcoholic Fatty Liver Disease via Improving Lipid and Glucose Metabolisms, and Inhibiting Inflammation in Type 2 Diabetes Rats. ( Gu, X; Li, X; Zhang, C; Zhu, H; Zou, W, 2021) |
| "Diabetic nephropathy is reported to occur as a result of the interactions between several pathophysiological disturbances, as well as renal oxidative stress and inflammation." | 1.62 | Malaysian Propolis and Metformin Synergistically Mitigate Kidney Oxidative Stress and Inflammation in Streptozotocin-Induced Diabetic Rats. ( Abu Bakar, AB; Jalil, NAC; Mohamed, M; Nna, VU; Othman, ZA; Zakaria, Z, 2021) |
| "Metformin is a biguanide antihyperglycemic drug used worldwide for the treatment of type 2 diabetes." | 1.62 | Metformin prevents p-tau and amyloid plaque deposition and memory impairment in diabetic mice. ( Araújo, SMR; Braga, CF; Duarte-Silva, E; França, MR; Lós, DB; Oliveira, WH; Peixoto, CA; Rocha, SWS; Rodrigues, GB, 2021) |
| "Metformin has been used to treat patients with type 2 diabetes mellitus (T2DM), and animal and clinical studies have reported therapeutic effects of metformin in Alzheimer's disease (AD)." | 1.62 | Metformin attenuates vascular pathology by increasing expression of insulin-degrading enzyme in a mixed model of cerebral amyloid angiopathy and type 2 diabetes mellitus. ( Ando, Y; Inoue, Y; Masuda, T; Misumi, Y; Ueda, M, 2021) |
| " Therefore, the present study investigated the protective effect of L-egt alone, or combined with metformin, on renal damage in a type-2 diabetic (T2D) rat model." | 1.62 | L-ergothioneine and its combination with metformin attenuates renal dysfunction in type-2 diabetic rat model by activating Nrf2 antioxidant pathway. ( Channa, ML; Dare, A; Nadar, A, 2021) |
| "Treatment with metformin improved these parameters." | 1.62 | Metformin mitigates impaired testicular lactate transport/utilisation and improves sexual behaviour in streptozotocin-induced diabetic rats. ( Abu Bakar, AB; Ahmad, A; Mohamed, M; Nna, VU, 2021) |
| "Our results indicate that painful diabetic neuropathy is associated with a serial of morphometric plasticity in the rat spinal cord including the numerical increase of the myelinated fibers in the spinothalamic tract and the oligodendrocytes in the spinal dorsal horn." | 1.56 | Stereological study on the numerical plasticity of myelinated fibers and oligodendrocytes in the rat spinal cord with painful diabetic neuropathy. ( He, YN; Lin, JY; Peng, B; Xu, BL; Zhu, N, 2020) |
| "This study investigates the fabrication, characterization and optimization of Linum usitatissimum mucilage (LSM) with sodium alginate mucoadhesive microspheres loaded metformin HCl, a sustained release dosage form prepared by ionic gelation technique." | 1.56 | Linum usitatissimum seed mucilage-alginate mucoadhesive microspheres of metformin HCl: Fabrication, characterization and evaluation. ( Ghumman, SA; Noreen, S; Tul Muntaha, S, 2020) |
| "Metformin is an anti-hyperglycemic drug which is beneficial for treating the both DM2 and DM1." | 1.56 | Effect of metformin on testicular expression and localization of leptin receptor and levels of leptin in the diabetic mice. ( Annie, L; Derkach, KV; Gurusubramanian, G; Jeremy, M; Roy, VK; Shpakov, AO, 2020) |
| "Metformin is a widely used hypoglycemic agent, while resistant starch (RS) is a novel dietary fiber that emerges as a nutritional strategy for metabolic disease." | 1.56 | A specific gut microbiota and metabolomic profiles shifts related to antidiabetic action: The similar and complementary antidiabetic properties of type 3 resistant starch from Canna edulis and metformin. ( Li, R; Luo, L; Ma, S; Qiao, S; Wang, N; Wang, X; Wu, J; Xu, W; Zhang, C; Zhang, Y; Zhao, B, 2020) |
| "Metformin (Met) was used as standard antidiabetic drug." | 1.56 | Neuromodulatory effects of green coffee bean extract against brain damage in male albino rats with experimentally induced diabetes. ( Abdel Moneim, AE; Abdel-Mohsen, DM; Akabawy, AMA; Al-Brakati, A; Albarakati, AJA; Amin, HK; Baty, RS; Daabo, HMA; Elmahallawy, EK; Habotta, OA; Kassab, RB; Salem, FEH; Taha, H, 2020) |
| "Metformin treatment led to an upregulation of clock regulatory genes such as melanopsin (Opn4) and aralkylamine N-acetyltransferase (Aanat)." | 1.56 | Metformin Corrects Abnormal Circadian Rhythm and Kir4.1 Channels in Diabetes. ( Alex, A; Bhatwadekar, AD; Di, R; Luo, Q; Mathew, D, 2020) |
| "Metformin has beneficial pharmacological effects on the preservation of peripheral nerves in diabetic rats and its effects are comparable to those of ALA." | 1.56 | Metformin Preserves Peripheral Nerve Damage with Comparable Effects to Alpha Lipoic Acid in Streptozotocin/High-Fat Diet Induced Diabetic Rats. ( Jin, HY; Kim, SH; Park, TS, 2020) |
| "This study evaluated the influence of type 2 diabetes mellitus on bone loss, bone repair and cytokine production in hyperglycemic rats, treated or not with metformin." | 1.56 | Impact of hyperglycemia and treatment with metformin on ligature-induced bone loss, bone repair and expression of bone metabolism transcription factors. ( Azarias, JS; Bastos, MF; Garcia, RP; Malta, FS; Miranda, TS; Ribeiro, GKDR; Shibli, JA, 2020) |
| "One of the complications of type 2 diabetes mellitus in men is steroidogenic and spermatogenic dysfunctions." | 1.56 | Normalization of Testicular Steroidogenesis and Spermatogenesis in Male Rats with Type 2 Diabetes Mellitus under the Conditions of Metformin Therapy. ( Bakhtyukov, AA; Bayunova, LV; Derkach, KV; Shpakov, AO; Zorina, II, 2020) |
| "Comorbid type 2 diabetes poses a great challenge to the global control of tuberculosis." | 1.56 | Disparate Effects of Metformin on Mycobacterium tuberculosis Infection in Diabetic and Nondiabetic Mice. ( Govan, B; Hansen, K; Henning, L; Ketheesan, N; Kupz, A; Miranda-Hernandez, S; Rush, CM; Sathkumara, HD, 2020) |
| "Metformin + ZY treatment significantly lowered blood glucose, water intake, urine total protein, urine albumin, urine volume, serum triglyceride, and serum cholesterol levels in the DN group." | 1.56 | Effects of HuoxueJiangtang decoction alone or in combination with metformin on renal function and renal cortical mRNA expression in diabetic nephropathy rats. ( Chu, S; Li, H; Liu, D; Liu, X; Qu, X; Shuai, Y; Zhang, X; Zhao, H, 2020) |
| "Metformin was found to have a wound healing effect through several mechanisms." | 1.51 | Stem cells and metformin synergistically promote healing in experimentally induced cutaneous wound injury in diabetic rats. ( El Bana, EA; Morsi, AA; Shawky, LM, 2019) |
| "Metformin, the first-line drug to treat type 2 diabetes (T2D), inhibits mitochondrial glycerolphosphate dehydrogenase in the liver to suppress gluconeogenesis." | 1.51 | Metformin increases glucose uptake and acts renoprotectively by reducing SHIP2 activity. ( Berg, M; Dash, SN; Dumont, V; Groop, PH; Hautala, LC; Lehtonen, S; Lindfors, S; Mirtti, T; Naams, JB; Nisen, H; Polianskyte-Prause, Z; Tienari, J; Tolvanen, TA; Van, M; Wähälä, K; Wang, H, 2019) |
| "Metformin was used as positive control." | 1.51 | Eugenol ameliorates insulin resistance, oxidative stress and inflammation in high fat-diet/streptozotocin-induced diabetic rat. ( Al-Trad, B; Al-Zoubi, M; Alkhateeb, H; Alsmadi, W, 2019) |
| "Metformin has long been used for glycemic control in diabetic state." | 1.51 | Down-regulation of steroidogenesis-related genes and its accompanying fertility decline in streptozotocin-induced diabetic male rats: ameliorative effect of metformin. ( Ahmad, A; Bakar, ABA; Mohamed, M; Nna, VU, 2019) |
| "Metformin HCl is an oral antihyperglycemic agent belonging to biguanides." | 1.51 | Metformin hydrochloride and wound healing: from nanoformulation to pharmacological evaluation. ( Abdel-Rahman, RF; El-Gamil, MA; El-Ridy, MS; Elsayed, I; Yehia, SA; Younis, MM, 2019) |
| " humilis or 2-hydroxy-destigloyl-6-deoxyswietenine acetate (mexicanolide 1) with glibenclamide resulted in a reduction of the antihyperglycemic effect while a significant increase was observed when they were dosed with metformin." | 1.51 | Multi-target antidiabetic mechanisms of mexicanolides from Swietenia humilis. ( Haddad, PS; Mata, R; Navarrete, A; Noriega, LG; Ovalle-Magallanes, B; Tovar, AR; Tovar-Palacio, C, 2019) |
| " After 6 weeks of metformin treatment, pharmacodynamic indexes were determined." | 1.51 | In vivo pharmacodynamic and pharmacokinetic effects of metformin mediated by the gut microbiota in rats. ( Chen, M; Gao, Y; Hu, J; Huang, W; Liu, M; Wu, B; Zhang, W, 2019) |
| " Based on experimental data, the combination index of the hypoglycemic drugs like metformin and gliclazide in combination with different doses of mangiferin was determined using COMPUSYN software." | 1.51 | Antidiabetic effect of mangiferin in combination with oral hypoglycemic agents metformin and gliclazide. ( Malarvizhi, R; Mani, S; Nithya, P; Sekar, V; Vasanthi, HR, 2019) |
| "A rodent model of type 2 diabetes (30 mg/kg streptozotocin and high-fat feeding in male Sprague-Dawley rats) was used to assess 12 weeks of co-treatment with a sodium-glucose cotransporter 2 inhibitor (SGLT2i) and exercise (EX; treadmill running) on glycemic control and exercise capacity." | 1.51 | The combination of exercise training and sodium-glucose cotransporter-2 inhibition improves glucose tolerance and exercise capacity in a rodent model of type 2 diabetes. ( Beebe, DA; Braun, B; Esler, WP; Gorgoglione, MF; Hamilton, KL; Linden, MA; Miller, BF; Ross, TT, 2019) |
| "The simulation of type 2 diabetes on the background of obesity in the animals has led to the development of signs of insulin's inhibition of insulin producing apparatus - some different expressions of dystrophy and degeneration of the β-cells." | 1.51 | MODERN ASPECTS OF SUGAR-REDUCING EFFECT OF THICK BEAN EXTRACT BASED ON A TYPE II DIABETES MODEL ON THE BACKGROUND OF OBESITY. ( Derkach, N; Korol, V; Rybak, V, 2019) |
| "5." | 1.48 | Changes in CYP2D enzyme activity following induction of type 2 diabetes, and administration of cinnamon and metformin: an experimental animal study. ( Ardakani, YH; Kasirzadeh, S; Lavasani, H; Rouini, MR; Sheikholeslami, B; Taheri, A, 2018) |
| "Von Frey filaments were used to assess tactile allodynia." | 1.48 | Evaluation of the neonatal streptozotocin model of diabetes in rats: Evidence for a model of neuropathic pain. ( Barragán-Iglesias, P; Delgado-Lezama, R; Granados-Soto, V; Hong, E; Loeza-Alcocer, E; Oidor-Chan, VH; Pineda-Farias, JB; Price, TJ; Salinas-Abarca, AB; Sánchez-Mendoza, A; Velazquez-Lagunas, I, 2018) |
| "Metformin functions as a stabilizer of atherosclerotic plaque to reduce acute coronary accent." | 1.48 | AMPKα inactivation destabilizes atherosclerotic plaque in streptozotocin-induced diabetic mice through AP-2α/miRNA-124 axis. ( Chen, Y; Guo, T; Liang, WJ; Shan, MR; Wang, SX; Wang, XQ; Zhang, M; Zhang, Y; Zhou, SN, 2018) |
| " Pharmacokinetic analysis was based on plasma and urine data concentrations." | 1.48 | The role of organic cation transporter 2 inhibitor cimetidine, experimental diabetes mellitus and metformin on gabapentin pharmacokinetics in rats. ( Baviera, AM; Benzi, JRL; de Moraes, NV; Stevens, JH; Yamamoto, PA, 2018) |
| "Pretreatment with liraglutide in diabetic and non-diabetic animals reduced infarct size as compared to controls, while only non-diabetic liraglutide-treated rats presented neurologic deficit decreases." | 1.48 | Neuroprotective effect of glucagon-like peptide-1 receptor agonist is independent of glycaemia normalization in type two diabetic rats. ( Chefu, S; Filchenko, I; Kolpakova, M; Simanenkova, A; Vlasov, T, 2018) |
| "In the present study, type 2 diabetes was induced in male Goto‑Kakizaki (GK) rats fed with high‑fat diet (HFD)." | 1.48 | Apelin‑13 ameliorates metabolic and cardiovascular disorders in a rat model of type 2 diabetes with a high‑fat diet. ( Fang, H; Hu, J; Li, M, 2018) |
| "Diabetic nephropathy is one of the most common and serious complications of diabetes mellitus." | 1.48 | Ameliorative effects of protodioscin on experimental diabetic nephropathy. ( Dong, Y; Guo, C; Liu, Y; Xie, G; Zhu, H, 2018) |
| "Obesity is a major cause of type 2 diabetes mellitus (T2DM) in mammals." | 1.46 | Development of a Novel Zebrafish Model for Type 2 Diabetes Mellitus. ( Nishimura, N; Shimada, Y; Zang, L, 2017) |
| "Comorbid depression was induced by five inescapable foot-shocks (2mA, 2ms duration) at 10s intervals on days 1, 5, 7, and 10." | 1.46 | Metformin and ascorbic acid combination therapy ameliorates type 2 diabetes mellitus and comorbid depression in rats. ( Kumar, M; Nayak, PK; Shivavedi, N; Tej, GNVC, 2017) |
| "Metformin was orally administered to control mice or mice with streptozotocin-induced diabetes." | 1.46 | Metformin protects against retinal cell death in diabetic mice. ( Cho, GJ; Choi, MY; Choi, WS; Kang, SS; Kim, HJ; Kim, M; Kim, SJ; Kim, YS; Lee, DH; Roh, GS; Yoo, JM, 2017) |
| "4% (400 and 800 mg dosage respectively) compared to initial diabetic values." | 1.46 | Anti-diabetic potential of Sapium ellipticum (Hochst) Pax leaf extract in Streptozotocin(STZ)-induced diabetic Wistar rats. ( Akinloye, OA; Ighodaro, OM, 2017) |
| "Metformin treatment led to maintained good glycemic control and improved neuropathy and pancreatic lesions in female SDT fatty rats." | 1.46 | Assessment of Pharmacological Responses to an Anti-diabetic Drug in a New Obese Type 2 Diabetic Rat Model. ( Fatchiyah, F; Miyajima, K; Murai, Y; Ohta, T; Shinohara, M; Tadaki, H; Yamada, T, 2017) |
| "Metformin treatment of T2DM rats produced dose-dependent significant reductions in urinary albumin and nephrin concentrations, glomerular basement membrane thickness (GBMT), and the foot process fusion rate (FPFR) compared with control T2DM model rats, whereas renal expression of nephrin protein and Nphs1 mRNA was dose-dependently increased by metformin treatment." | 1.46 | Metformin ameliorates podocyte damage by restoring renal tissue nephrin expression in type 2 diabetic rats. ( Gu, J; Hu, W; Wang, W; Yang, D; Ye, S; Zhai, L, 2017) |
| "Geniposide (GPO) was previously demonstrated to modulate glucose metabolism in diabetes." | 1.46 | Geniposide reduces development of streptozotocin-induced diabetic nephropathy via regulating nuclear factor-kappa B signaling pathways. ( Chen, F; Hu, X; Jin, G; Shi, Z; Sun, W; Zhang, X, 2017) |
| "Metformin (MET) is a first-line drug for type 2 diabetes mellitus (DM); its effect on new-onset diabetes after transplantation caused by immunosuppressant therapy is unclear." | 1.46 | Effects of metformin on hyperglycemia in an experimental model of tacrolimus- and sirolimus-induced diabetic rats. ( Chung, BH; Jin, J; Jin, L; Kim, HS; Lim, SW; Yang, CW; Yu, JH, 2017) |
| " These results suggest that metformin administration reversed the adverse effects of diabetes on orthodontic tooth movement." | 1.46 | Histological evidence that metformin reverses the adverse effects of diabetes on orthodontic tooth movement in rats. ( Amizuka, N; Du, J; Feng, W; Guo, J; Li, M; Liu, H; Lu, B; Sun, J, 2017) |
| "Metformin is an anti-diabetic agent and its potential antitumor impact has become the objective of numerous studies." | 1.46 | Metformin enhancing the antitumor efficacy of carboplatin against Ehrlich solid carcinoma grown in diabetic mice: Effect on IGF-1 and tumoral expression of IGF-1 receptors. ( Abo-Elmatty, DM; Ahmed, EA; Helmy, SA; Tawfik, MK, 2017) |
| " Chitosan cross-linked alginate provides improvement of swelling and mucoadhesive properties and might be used to design sustained release dosage forms." | 1.46 | The Influence of Chitosan Cross-linking on the Properties of Alginate Microparticles with Metformin Hydrochloride-In Vitro and In Vivo Evaluation. ( Kasacka, I; Lewandowska, A; Sosnowska, K; Szekalska, M; Winnicka, K; Zakrzeska, A, 2017) |
| "Metformin were used as reference antihyperglycemic drugs for comparison." | 1.46 | Pharmacological evaluation of aqueous extract of syzigium cumini for its antihyperglycemic and antidyslipidemic properties in diabetic rats fed a high cholesterol diet-Role of PPARγ and PPARα. ( Dua, K; Gupta, G; Mishra, A; Pathak, S; Sharma, RK; Sharma, S; Sharma, SK; Singh, L, 2017) |
| "Metformin has been used for the treatment of diabetes, whereas atorvastatin reduces the incidence of atherosclerosis and ischemic heart disease." | 1.43 | Ameliorative Effect of Adjunct Therapy of Metformin with Atorvastatin on Streptozotocin-induced Diabetes Mellitus in Rats. ( Kumar, V; Singh, A; Singh, BK, 2016) |
| "Hyperinsulinemia is thought to enhance cancer risk." | 1.43 | Metformin Protects Kidney Cells From Insulin-Mediated Genotoxicity In Vitro and in Male Zucker Diabetic Fatty Rats. ( Arias-Loza, PA; Kreissl, MC; Oli, RG; Othman, EM; Stopper, H, 2016) |
| "Finally, when compared to untreated type 2 diabetes patients, the metformin-treated diabetic patients showed increased IGFBP-2 levels with diminished serum IGF-1 levels." | 1.43 | Metformin stimulates IGFBP-2 gene expression through PPARalpha in diabetic states. ( Cho, HC; Choi, HS; Im, SS; Kang, HS; Koo, SH; Lee, IK; Lee, JH; Oh, GT; Park, BH; Song, DK, 2016) |
| "Treatment with metformin reduced the expression of GFAP, Iba-1 (astrocyte and microglial markers) and the inflammation markers (p-IKB, IL-1 and VEGF), while enhancing p-AMPK and eNOS levels and increasing neuronal survival (Fox-1 and NeuN)." | 1.43 | Effects of metformin on inflammation and short-term memory in streptozotocin-induced diabetic mice. ( Barbosa, KP; França, ME; Lós, DB; Nunes, AK; Oliveira, WH; Peixoto, CA; Rocha, SW; Rodrigues, GB; Santos, LA, 2016) |
| " Given that lowering glucose is the first objective of diabetic patients, we also examined the effects of SAA combined with metformin (MET) on both complications." | 1.43 | Effects of the Nrf2 Protein Modulator Salvianolic Acid A Alone or Combined with Metformin on Diabetes-associated Macrovascular and Renal Injury. ( Du, GH; He, YY; Hou, BY; Ma, LL; Niu, ZR; Pang, XC; Song, JK; Wu, P; Yan, Y; Yang, XY; Zhang, L, 2016) |
| " In STZ-induced diabetic rats the long-term administration of metformin normalized reduced PON1 activity assayed toward paraoxon (+42." | 1.43 | The paraoxonase 1 (PON1), platelet-activating factor acetylohydrolase (PAF-AH) and dimethylarginine dimethylaminohydrolase (DDAH) activity in the metformin treated normal and diabetic rats. ( Bełtowski, J; Czechowska, G; Jamroz-Wiśniewska, A; Korolczuk, A; Marciniak, S; Wójcicka, G, 2016) |
| "Their anti-type 2 diabetes activity was evaluated in HepG2 cell and db/db mice." | 1.42 | Design, synthesis and biological evaluation of GY3-based derivatives for anti-type 2 diabetes activity. ( Fan, L; Li, Z; Ma, X; Tang, L; Wang, J; Wu, H; Xiao, W; Zhong, G, 2015) |
| "Hyperglycemia and hyperlipidemia directly affected the contractile function of VSMCs." | 1.42 | Diabetes and hyperlipidemia induce dysfunction of VSMCs: contribution of the metabolic inflammation/miRNA pathway. ( Chen, XY; Lan, D; Li, T; Liu, LM; Tian, KL; Wu, Y; Yang, GM; Zhu, Y, 2015) |
| "Chronic pain is a common complication of diabetes." | 1.42 | Characterisation of pain responses in the high fat diet/streptozotocin model of diabetes and the analgesic effects of antidiabetic treatments. ( Byrne, FM; Chapman, V; Cheetham, S; Vickers, S, 2015) |
| "Type 2 diabetes is a chronic disease that cannot be treated adequately using the known monotherapies, especially when the disease progresses to an advanced stage." | 1.42 | Combination therapy with oleanolic acid and metformin as a synergistic treatment for diabetes. ( Abdelkader, D; Chen, Y; Hassan, W; Liu, J; Sun, H; Wang, X, 2015) |
| "Thus far, the treatment of painful diabetic neuropathy remains unsatisfactory." | 1.42 | Metformin attenuates hyperalgesia and allodynia in rats with painful diabetic neuropathy induced by streptozotocin. ( Chen, Y; Liu, J; Ma, J; Wang, Q; Xiang, L; Yu, H, 2015) |
| "Here metformin was delivered to diabetic mice and has got significant anti-diabetic effect can be considered as a kind of patch for NIDDM just like wearing and taking off a hand watch because hypoglycaemia can be removed by just taking off the patch." | 1.42 | A therapeutic TDS patch of Metformin from a HPMC-PVA blend studied with a biological membrane of fish-swim bladder: An approach for dermal application in NIDDM. ( Ferdaus, R; Jahan, L; Shaheen, SM, 2015) |
| "Metformin and glyburide treatment decreased the levels of BG and HbA1c [(9." | 1.42 | [Protective effects of metformin on glomerular podocytes of type 2 diabetes model rats]. ( Gu, J; Hu, W; Yang, D; Ye, S; Zhai, L, 2015) |
| "Metformin treatment was similarly evaluated and found not to have adverse effects on pancreas." | 1.40 | Characterization of the exocrine pancreas in the male Zucker diabetic fatty rat model of type 2 diabetes mellitus following 3 months of treatment with sitagliptin. ( Cunningham, C; Dey, M; Forest, T; Frederick, C; Holder, D; Prahalada, S; Smith, A; Yao, X, 2014) |
| " At termination, basilar arteries were collected and cumulative dose-response curves to ET-1 (0." | 1.40 | Late dual endothelin receptor blockade with bosentan restores impaired cerebrovascular function in diabetes. ( Abdelsaid, M; Coucha, M; Ergul, A; Ma, H, 2014) |
| "Metformin treatment prevented weight gain ((315." | 1.40 | Gliquidone versus metformin: differential effects on aorta in streptozotocin induced diabetic rats. ( Gui, Q; Tan, Z; Wu, W; Xu, Z; Yang, Y, 2014) |
| "Metformin treatment was effective in lowering hyperglycemia only during the first 2 weeks of treatment." | 1.40 | Daily exercise training protects against albuminuria and angiotensin converting enzyme 2 shedding in db/db diabetic mice. ( Boivin, GP; Elased, KM; Somineni, HK, 2014) |
| "Metformin is a widely prescribed drug for the treatment of type 2 diabetes." | 1.40 | Metformin impairs mitochondrial function in skeletal muscle of both lean and diabetic rats in a dose-dependent manner. ( Ciapaite, J; Nicolay, K; Prompers, JJ; van den Broek, NM; Wessels, B, 2014) |
| "Colon cancer was induced using 1,2-dimethylhydrazine (DMH, 20 mg/kg/week, s." | 1.40 | Role of metformin in suppressing 1,2-dimethylhydrazine-induced colon cancer in diabetic and non-diabetic mice: effect on tumor angiogenesis and cell proliferation. ( Moustafa, YM; Zaafar, DK; Zaitone, SA, 2014) |
| "Treatment with metformin or Meilian Xiaoke capsule alone for 2 or 4 weeks did not produce significant improvement of blood glucose in the diabetic rats." | 1.40 | [Meilian Xiaoke capsule combined with metformin for protecting islet cells and lowering blood glucose in diabetic rats]. ( Hu, C; Jin, X; Tong, L; Zhang, S, 2014) |
| " These results indicated that chronic administration of Met regulated pancreatic inflammation generation, ion and hormone homeostasis and improved β cell function of diabetic KKAy mice." | 1.40 | [Metformin ameliorates β-cell dysfunction by regulating inflammation production, ion and hormone homeostasis of pancreas in diabetic KKAy mice]. ( Hou, SC; Liu, Q; Liu, SN; Shen, ZF; Sun, SJ; Wang, Y, 2014) |
| "Metformin was used as a standard drug." | 1.39 | Anti-diabetic effect of Murraya koenigii (L) and Olea europaea (L) leaf extracts on streptozotocin induced diabetic rats. ( Al-Olayan, EM; Almarhoon, ZM; Daghestani, MH; El-Amin, M; Elobeid, MA; Hassan, ZK; Merghani, NM; Omer, SA; Virk, P, 2013) |
| "Metformin treatment prevented the diabetes-induced alterations in bone micro-architecture and BMPC osteogenic potential." | 1.39 | Insulin-deficient diabetes-induced bone microarchitecture alterations are associated with a decrease in the osteogenic potential of bone marrow progenitor cells: preventive effects of metformin. ( Chuguransky, SR; Cortizo, AM; McCarthy, AD; Molinuevo, MS; Schurman, L; Sedlinsky, C; Tolosa, MJ, 2013) |
| "Metformin has been reported to increase the expression of the glucagon-like peptide-1 (GLP-1) receptor in pancreatic beta cells in a peroxisome proliferator-activated receptor (PPAR)-α-dependent manner." | 1.39 | Effect of the combination of metformin and fenofibrate on glucose homeostasis in diabetic Goto-Kakizaki rats. ( Cho, YM; Kang, GH; Oh, TJ; Park, KS; Shin, JY, 2013) |
| "However, in most patients with type II diabetes mellitus (T2DM), it was found that metformin alone is not enough to adequately control hyperglycemia." | 1.39 | Potential utility of sodium selenate as an adjunct to metformin in treating type II diabetes mellitus in rats: a perspective on protein tyrosine phosphatase. ( Elkoussi, AA; Khalifa, AE; Salama, RM; Schaalan, MF, 2013) |
| "Semecarpus anacardium nut milk extract at a dosage of 200 mg/kg orally significantly (p < 0." | 1.39 | Anti-inflammatory and anti-hyperlipidemic effect of Semecarpus anacardium in a high fat diet: STZ-induced type 2 diabetic rat model. ( Khan, HB; Moorthy, BT; Palanivelu, S; Panchanatham, S; Vinayagam, KS, 2013) |
| " The pharmacokinetic and pharmacodynamic evaluation of selected formulation was carried out in male Wistar diabetic rats." | 1.39 | Pharmacokinetic and pharmacodynamic evaluation of floating microspheres of metformin hydrochloride. ( Devi, K; Inamdar, MN; Pai, RS; Pandit, V; Surekha, BB; Suresh, S; Yadav, V, 2013) |
| " Diabetic rats were treated with SA orally at a dosage of 200 mg/kg body weight daily for 30 days." | 1.39 | Potential antidiabetic effect of the Semecarpus anacardium in a type 2 diabetic rat model. ( Khan, HB; Palanivelu, S; Panchanadham, S; Renny, CM; Vinayagam, KS, 2013) |
| " The bioavailability of compound 70 and its isomer varies between 27 and 29% whereas that of the more polar compound 90a is poor as determined in rat by oral and intraperitoneal administrations." | 1.38 | Flavone-based novel antidiabetic and antidyslipidemic agents. ( Dwivedi, AK; Nath, C; Pratap, R; Raghubir, R; Satyanarayana, M; Singh, AB; Singh, H; Singh, SK; Srivastava, AK; Srivastava, M; Srivastava, SP; Tiwari, P; Verma, AK, 2012) |
| "Treatment with metformin for 4 weeks attenuated the increased levels of Angptl4 mRNA." | 1.38 | Reduction of insulin signaling upregulates angiopoietin-like protein 4 through elevated free fatty acids in diabetic mice. ( Arima, H; Fukami, A; Fukuyama, T; Mizutani, N; Nagasaki, H; Oiso, Y; Ozaki, N; Sakamoto, E; Seino, Y; Sugimura, Y, 2012) |
| "Metformin treated group showed a decrease in blood glucose by 70 mg/dl, as against an increase in diabetic control group by 125 mg/dl." | 1.38 | Antihyperglycemic and antihyperlipidemic effect of Santalum album in streptozotocin induced diabetic rats. ( Arvindekar, AU; Joglekar, MM; Kulkarni, CR; Patil, SB, 2012) |
| "Diabetic nephropathy is a major cause of morbidity and mortality in diabetic patients." | 1.38 | Fenugreek attenuation of diabetic nephropathy in alloxan-diabetic rats: attenuation of diabetic nephropathy in rats. ( Abd el-Latif, FF; Khalifa, M; Sayed, AA, 2012) |
| " Three days after STZ induction, the hyperglycemic rats were treated with Semecarpus anacardium nut milk extract (SA) orally at a dosage of 200 mg/kg body weight daily for 30 days." | 1.38 | Antidiabetic and antioxidant effect of Semecarpus anacardium Linn. nut milk extract in a high-fat diet STZ-induced type 2 diabetic rat model. ( Khan, HB; Palanivelu, S; Panchanadham, S; Sekar, A; Vinayagam, KS, 2012) |
| " Diabetic rats were dosed with i." | 1.37 | Antihyperglycemic effects of baicalin on streptozotocin - nicotinamide induced diabetic rats. ( Davey, AK; Li, HT; Wang, J; Wu, XD, 2011) |
| "A dose-response study was conducted to determine optimum dose for the hypoglycemic effect of VA in STZ-induced diabetic rats." | 1.37 | Polyphenols-rich Vernonia amygdalina shows anti-diabetic effects in streptozotocin-induced diabetic rats. ( Hsu, A; Huang, D; Ong, KW; Song, L; Tan, BK, 2011) |
| "Approximately 40% of patients with type 2 diabetes may progress to nephropathy and a good metabolic control can prevent the development of diabetic renal injury." | 1.37 | Insulin and metformin may prevent renal injury in young type 2 diabetic Goto-Kakizaki rats. ( da Cunha, FX; Louro, TM; Matafome, PN; Nunes, EC; Seiça, RM, 2011) |
| "non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes are associated with dyslipidaemia, inflammation and oxidative stress." | 1.37 | Metformin and atorvastatin combination further protect the liver in type 2 diabetes with hyperlipidaemia. ( Amaral, C; Cipriano, A; Crisóstomo, J; Louro, T; Matafome, P; Monteiro, P; Nunes, E; Rodrigues, L; Seiça, R, 2011) |
| "Treatment with metformin sensitized the impaired insulin actions and also prevented appearance of molecular and pathological characteristics observed in AD." | 1.37 | Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer's-like changes. ( Bisht, B; Dey, CS; Gupta, A, 2011) |
| "05) reduced hyperglycemia, glibenclamide or metformin combined with honey produced significantly much lower blood glucose (8." | 1.37 | Glibenclamide or metformin combined with honey improves glycemic control in streptozotocin-induced diabetic rats. ( Erejuwa, OO; Gurtu, S; Salleh, MS; Sirajudeen, KN; Sulaiman, SA; Wahab, MS, 2011) |
| "On the other hand, treatment of diabetic nephropathy rats with metformin normalized all biochemical changes and the energy status in kidney tissues." | 1.37 | Metformin attenuates streptozotocin-induced diabetic nephropathy in rats through modulation of oxidative stress genes expression. ( Alhaider, AA; Kfoury, H; Korashy, HM; Mansour, MA; Mobark, M; Sayed-Ahmed, MM, 2011) |
| "Metformin was administered i." | 1.37 | The effect of metformin on the myocardial tolerance to ischemia-reperfusion injury in the rat model of diabetes mellitus type II. ( Bairamov, A; Galagudza, M; Grineva, E; Kravchuk, E; Vlasov, T, 2011) |
| "Catalpol was found to increase glycogen synthesis in STZ-diabetic rats." | 1.36 | Antihyperglycemic effect of catalpol in streptozotocin-induced diabetic rats. ( Cheng, JT; Hsu, FL; Huang, WJ; Lin, MH; Niu, HS, 2010) |
| "Of all drugs used in the treatment of Type 2 diabetes, the insulin sensitizers thiazolidinediones (e." | 1.36 | Gastroprotective effects of the insulin sensitizers rosiglitazone and metformin against indomethacin-induced gastric ulcers in Type 2 diabetic rats. ( Abdel-Gaber, SA; Ashour, OM; Fouad, AA; Morsy, MA, 2010) |
| "Metformin treatment also stimulated bone lesion regeneration in control and diabetic rats." | 1.36 | Effect of metformin on bone marrow progenitor cell differentiation: in vivo and in vitro studies. ( Arnol, V; Cortizo, AM; Gangoiti, MV; McCarthy, AD; Molinuevo, MS; Schurman, L; Sedlinsky, C; Tolosa, MJ, 2010) |
| "Metformin treatment significantly decreased the blood glucose levels from 15." | 1.36 | Metformin normalizes type 2 diabetes-induced decrease in cell proliferation and neuroblast differentiation in the rat dentate gyrus. ( Choi, JW; Hwang, IK; Joo, EJ; Kim, IY; Seong, JK; Shin, JH; Won, MH; Yoon, YS, 2010) |
| " This study investigated the hypothesis that the common antidiabetic drugs glibenclamide and metformin, in combination with tualang honey, offer additional protection for the pancreas of streptozotocin (STZ)-induced diabetic rats against oxidative stress and damage." | 1.36 | Antioxidant protective effect of glibenclamide and metformin in combination with honey in pancreas of streptozotocin-induced diabetic rats. ( Erejuwa, OO; Gurtu, S; Salam, SK; Salleh, MS; Sulaiman, SA; Wahab, MS, 2010) |
| "Metformin treatment decreased glucose concentration, glycated haemoglobin % and improved glucose tolerance." | 1.36 | Influence of metformin on GLUT1 gene and protein expression in rat streptozotocin diabetes mellitus model. ( Isajevs, S; Kalvinsh, I; Lauberte, L; Rostoka, E; Sharipova, J; Sjakste, N; Sjakste, T; Sokolovska, J; Sugoka, O; Svirina, D, 2010) |
| "The animal model of type 2 diabetes with hepatic fibrosis was successfully made." | 1.36 | [Effect of metformin on the formation of hepatic fibrosis in type 2 diabetic rats]. ( Chen, BN; Du, GH; Qiang, GF; Shi, LL; Xuan, Q; Yang, XY; Zhang, HA; Zhang, L, 2010) |
| "Treatment with metformin normalized these alterations including the renal proteins and LPO, confirming its efficacy in ameliorating dexamethasone-induced type-2 DM and also the association of two proteins with type-2 DM." | 1.36 | Effect of metformin on renal microsomal proteins, lipid peroxidation and antioxidant status in dexamethasone-induced type-2 diabetic mice. ( Jatwa, R; Kar, A, 2010) |
| "Metformin is an effective antihyperglycemic agent used in the treatment of diabetes." | 1.35 | Effects of metformin on QT and QTc interval dispersion of diabetic rats. ( Areas, MA; Costa, EC; Gonçalves, AA; Morgabel, RG, 2008) |
| "The animal models of type 2 diabetes are very complex and are as heterogeneous as the disease." | 1.35 | Metabolic effects of various antidiabetic and hypolipidaemic agents on a high-fat diet and multiple low-dose streptozocin (MLDS) mouse model of diabetes. ( Arulmozhi, DK; Bodhankar, SL; Kurian, R; Veeranjaneyulu, A, 2008) |
| " The concentrations of metformin hydrochloride in plasma were determined by HPLC method and the pharmacokinetic parameters were calculated." | 1.35 | [Effects of Yuquan pills on pharmacokinetics of metformin hydrochloride in diabetic rats]. ( Duan, HG; Li, BX; Wei, YH; Wu, XA; Zhang, DM; Zhang, JW, 2008) |
| "Treatment with metformin ameliorated these biochemical markers." | 1.35 | Assessment of genomic instability in normal and diabetic rats treated with metformin. ( Alhaider, AA; Attia, SM; Helal, GK, 2009) |
| "Metformin was metabolized via hepatic CYP2C11, 2D1, and 3A1/2 in rats." | 1.35 | Effects of diabetes mellitus induced by alloxan on the pharmacokinetics of metformin in rats: restoration of pharmacokinetic parameters to the control state by insulin treatment. ( Choi, YH; Lee, I; Lee, MG, 2008) |
| "Renal hypertrophy in rats with Type 1 diabetes was associated with reduction in AMPK phosphorylation and increased mTOR activity." | 1.34 | A role for AMP-activated protein kinase in diabetes-induced renal hypertrophy. ( Choudhury, GG; Feliers, D; Foretz, M; Kasinath, BS; Lee, MJ; Mahimainathan, L; Mariappan, MM; Musi, N; Sataranatarajan, K; Viollet, B; Weinberg, JM, 2007) |
| " In this study, the effects of an oral administration of SD at dosages of 100, 300, and 500 mg kg(-1) once a day, respectively, on the formation of insulin resistance were investigated in vivo in two models of insulin-resistant rats, HFD rats (high-fat diet-induced insulin-resistant rats) and IILI rats (induced by the intraperitoneal injections of long-acting insulin at dosage of 0." | 1.33 | Effect of Sanguis draxonis (a Chinese traditional herb) on the formation of insulin resistance in rats. ( Hou, Z; Wu, H; Zhang, Z, 2005) |
| "Metformin is a biguanide derivate used as an oral hypoglycaemic drug in diabetics." | 1.33 | Protective effects of metformin treatment on the liver injury of streptozotocin-diabetic rats. ( Bolkent, S; Karabulut-Bulan, O; Orak, H; Ozsoy-Sacan, O; Yanardag, R, 2005) |
| "Rosiglitazone or metformin were found to exhibit a hypolipidaemic effect in diabetic rats when administered alone or in combination." | 1.33 | Effect of rosiglitazone and nateglinide on serum glucose and lipid profile alone or in combination with the biguanide metformin in diabetic rats. ( Abdel-Salam, OM; Baiuomy, AR; El-Batran, SA; Nofal, SM, 2006) |
| "The metformin group was treated with 200 mg/kg/d in water and the control group was pair-fed the same volume of liquid diet." | 1.33 | Effects of insulin sensitizers on islet transplantation. ( Hsu, BR; Juang, JH; Kuo, CH, 2005) |
| "Metformin treatment reduced blood pressure without having any significant effect on blood glucose level in STZ-diabetic rats." | 1.33 | Metformin reduces blood pressure and restores endothelial function in aorta of streptozotocin-induced diabetic rats. ( Balaraman, R; Majithiya, JB, 2006) |
| "Metformin vs placebo treatment of diabetic pigs (twice 1." | 1.33 | Association of insulin resistance with hyperglycemia in streptozotocin-diabetic pigs: effects of metformin at isoenergetic feeding in a type 2-like diabetic pig model. ( Ackermans, M; Corbijn, H; Dekker, R; Koopmans, SJ; Mroz, Z; Sauerwein, H, 2006) |
| "To analyze, in acute renal failure (ARF) in diabetic rats, how moderate functional ARF would modify metformin (MET) pharmacokinetics and if plasma and renal tissue MET accumulation could aggravate renal insufficiency and/or elicit plasma lactate accumulation." | 1.32 | Mild acute renal failure potentiates metformin accumulation in the diabetic rat kidney without further impairment of renal function. ( Barthelmebs, M; Grima, M; Imbs, JI; Krieger, JP; Radziuk, J; Rapin, JR; Wiernsperger, N, 2003) |
| " The pharmacokinetics of metformin from the mucoadhesive dosage forms indicated that for metformin alone, the area under the curve (AUC) values were 125." | 1.32 | Pharmacodynamic-pharmacokinetic profiles of metformin hydrochloride from a mucoadhesive formulation of a polysaccharide with antidiabetic property in streptozotocin-induced diabetic rat models. ( Adikwu, MU; Takada, K; Yoshikawa, Y, 2004) |
| " Streptozotocin diabetic rats received metformin in crossover fashion via intraduodenal, intravenous, and intraportal routes as bolus dose or infusion regimens designed to yield similar pharmacokinetic profiles." | 1.31 | Pharmacokinetic-pharmacodynamic analysis of the glucose-lowering effect of metformin in diabetic rats reveals first-pass pharmacodynamic effect. ( Friedman, M; Hoffman, A; Raz, I; Stepensky, D, 2002) |
| "The plasma glucose-lowering action induced by tolbutamide was significantly enhanced in obese Zucker rats receiving the repeated administration of die-huang-wan at dosage of 26 mg/kg for 3 d." | 1.31 | Increase of insulin sensitivity in diabetic rats received die-huang-wan, a herbal mixture used in Chinese traditional medicine. ( Cheng, JT; Hsu, JH; Liou, SS; Liu, IM; Su, HC; Wu, YC, 2002) |
| "We examined the pharmacokinetic (PK) and pharmacodynamic (PD) rationales to develop controlled release (CR) formulations of metformin." | 1.31 | Preclinical evaluation of pharmacokinetic-pharmacodynamic rationale for oral CR metformin formulation. ( Friedman, M; Hoffman, A; Raz, I; Srour, W; Stepensky, D, 2001) |
| "Treatment with metformin led to decreased diabetes-induced TxCAD in the larger vessels." | 1.31 | Reversal of diabetes-induced rat graft transplant coronary artery disease by metformin. ( Cantin, B; Dai, X; Gwathmey, JK; Panchal, SN; Reaven, GM; Valantine, HA; Wen, P; Zhu, D, 2002) |
| "Metformin treatment of the diabetic rats did not prevent the development of these contractile changes." | 1.30 | The influence of streptozotocin diabetes and metformin on erythrocyte volume and on the membrane potential and the contractile characteristics of the extensor digitorum longus and soleus muscles in rats. ( MacDermott, M; McGuire, M, 1999) |
| "Metformin treatment did not affect the ventricular responses in control rats." | 1.29 | Metformin improves cardiac function in isolated streptozotocin-diabetic rat hearts. ( McNeill, JH; Verma, S, 1994) |
| "Metformin treatment was followed by a significant decrease in the growth rate and normalized glucose tolerance without enhancing the deficient insulin response." | 1.28 | Effect of metformin treatment on insulin action in diabetic rats: in vivo and in vitro correlations. ( Andraghetti, G; Cordera, R; DeFronzo, RA; Falzetti, G; Gherzi, R; Klein-Robbenhaar, E; Rossetti, L; Shulman, GI; Stein, P, 1990) |
| "When metformin was withdrawn after treatment for 96 h, the number of low affinity receptors decreased, approaching control values by 48 h." | 1.27 | Effect of metformin on hepatocyte insulin receptor binding in normal, streptozotocin diabetic and genetically obese diabetic (ob/ob) mice. ( Atkins, TW; Bailey, CJ; Lord, JM, 1983) |
| "Treatment with metformin (250 mg/kg/day orally for 3 weeks) reduced by 39% the severity of streptozotocin-induced hyperglycaemia." | 1.27 | Effect of metformin on glucose metabolism in mouse soleus muscle. ( Bailey, CJ; Puah, JA, 1986) |
| " Metformin, administered at 200 mg/kg per os, ineffective dosage in normal mice, showed a strong hypoglycemic effect in younger mice (11--18 weeks) with a plasma IRI decrease and no blood lactate and liver glycogen alteration." | 1.26 | DBM mice as a pharmacological model of maturity onset diabetes. Studies with metformin. ( Brohon, J; Guillaume, M; Junien, JL; Sterne, J, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (2.58) | 18.7374 |
| 1990's | 25 (4.03) | 18.2507 |
| 2000's | 71 (11.43) | 29.6817 |
| 2010's | 300 (48.31) | 24.3611 |
| 2020's | 209 (33.66) | 2.80 |
| Authors | Studies |
|---|---|
| Dumić, M | 1 |
| Vinković, M | 1 |
| Filić, D | 1 |
| Jamnicky, B | 1 |
| Eskinja, M | 1 |
| Kamenar, B | 1 |
| Manickam, M | 1 |
| Ramanathan, M | 1 |
| Jahromi, MA | 1 |
| Chansouria, JP | 1 |
| Ray, AB | 1 |
| Cottineau, B | 1 |
| Toto, P | 1 |
| Marot, C | 1 |
| Pipaud, A | 1 |
| Chenault, J | 1 |
| Kumar, A | 6 |
| Pathak, SR | 1 |
| Ahmad, P | 4 |
| Ray, S | 1 |
| Tewari, P | 1 |
| Srivastava, AK | 23 |
| Shukla, P | 1 |
| Singh, AB | 12 |
| Pratap, R | 2 |
| Narender, T | 3 |
| Shweta, S | 1 |
| Tiwari, P | 2 |
| Papi Reddy, K | 2 |
| Khaliq, T | 2 |
| Prathipati, P | 1 |
| Puri, A | 2 |
| Chander, R | 1 |
| Agarwal, SC | 2 |
| Raj, K | 1 |
| Singh, FV | 2 |
| Chaurasia, S | 2 |
| Joshi, MD | 2 |
| Goel, A | 2 |
| Dwivedi, AP | 1 |
| Kumar, S | 3 |
| Varshney, V | 1 |
| Sahu, DP | 1 |
| Maurya, RA | 3 |
| Mishra, P | 1 |
| Chaturvedi, JP | 1 |
| Maurya, R | 5 |
| Saxena, AK | 2 |
| Pandey, G | 2 |
| Gupta, S | 2 |
| Parihar, A | 1 |
| Singh, SP | 1 |
| Tamrakar, AK | 6 |
| Sharma, S | 4 |
| Tripathi, VD | 1 |
| Srivastava, SP | 3 |
| Bhatia, G | 1 |
| Huang, WJ | 1 |
| Niu, HS | 1 |
| Lin, MH | 1 |
| Cheng, JT | 5 |
| Hsu, FL | 1 |
| Rahuja, N | 5 |
| Rawat, P | 1 |
| Kumar, M | 3 |
| Lal Srivastava, DS | 1 |
| Jiang, Z | 1 |
| Du, Q | 1 |
| Lam, SH | 1 |
| Ruan, CT | 1 |
| Hsieh, PH | 1 |
| Su, MJ | 1 |
| Lee, SS | 1 |
| Gupta, LP | 1 |
| Verma, AK | 1 |
| Singh, H | 1 |
| Satyanarayana, M | 1 |
| Dwivedi, AK | 1 |
| Singh, SK | 1 |
| Srivastava, M | 1 |
| Nath, C | 1 |
| Raghubir, R | 1 |
| Huang, CH | 1 |
| Chen, MF | 1 |
| Chung, HH | 1 |
| Zhang, B | 2 |
| Chen, T | 1 |
| Chen, Z | 4 |
| Wang, M | 3 |
| Zheng, D | 2 |
| Wu, J | 4 |
| Jiang, X | 3 |
| Li, X | 21 |
| Venier, O | 1 |
| Pascal, C | 1 |
| Braun, A | 1 |
| Namane, C | 1 |
| Mougenot, P | 1 |
| Crespin, O | 1 |
| Pacquet, F | 1 |
| Mougenot, C | 1 |
| Monseau, C | 1 |
| Onofri, B | 1 |
| Dadji-Faïhun, R | 1 |
| Leger, C | 1 |
| Ben-Hassine, M | 1 |
| Van-Pham, T | 1 |
| Ragot, JL | 1 |
| Philippo, C | 1 |
| Farjot, G | 1 |
| Noah, L | 1 |
| Maniani, K | 1 |
| Boutarfa, A | 1 |
| Nicolaï, E | 1 |
| Guillot, E | 1 |
| Pruniaux, MP | 1 |
| Güssregen, S | 1 |
| Engel, C | 1 |
| Coutant, AL | 1 |
| de Miguel, B | 1 |
| Castro, A | 1 |
| Park, K | 1 |
| Lee, BM | 1 |
| Hyun, KH | 1 |
| Lee, DH | 2 |
| Choi, HH | 1 |
| Kim, H | 3 |
| Chong, W | 1 |
| Kim, KB | 1 |
| Nam, SY | 1 |
| Fan, L | 1 |
| Wang, J | 13 |
| Ma, X | 3 |
| Xiao, W | 1 |
| Li, Z | 7 |
| Zhong, G | 1 |
| Tang, L | 2 |
| Wu, H | 2 |
| Bhosle, MR | 1 |
| Deshmukh, AR | 1 |
| Pal, S | 1 |
| Mane, RA | 1 |
| Patel, OP | 1 |
| Mishra, A | 3 |
| Saini, D | 1 |
| Pandey, J | 1 |
| Taneja, I | 1 |
| Raju, KS | 1 |
| Kanojiya, S | 1 |
| Shukla, SK | 1 |
| Srivastava, MN | 1 |
| Wahajuddin, M | 1 |
| Yadav, PP | 1 |
| Yang, J | 1 |
| Li, H | 7 |
| Liu, C | 7 |
| Wang, N | 4 |
| Shi, W | 1 |
| Liao, C | 1 |
| Cai, X | 2 |
| Huang, W | 3 |
| Qian, H | 1 |
| Deng, X | 1 |
| Shen, J | 4 |
| Zhu, H | 3 |
| Xiao, J | 1 |
| Sun, R | 1 |
| Xie, F | 1 |
| Lam, C | 1 |
| Qiao, Y | 1 |
| Tavallaie, MS | 1 |
| Hu, Y | 1 |
| Du, Y | 1 |
| Li, J | 18 |
| Fu, L | 1 |
| Jiang, F | 2 |
| Li, N | 1 |
| Wang, LJ | 1 |
| Jiang, B | 1 |
| Guo, SJ | 1 |
| Li, XQ | 1 |
| Chen, XC | 1 |
| Luo, J | 3 |
| Li, C | 4 |
| Wang, Y | 15 |
| Shi, DY | 1 |
| Chen, M | 2 |
| Wang, K | 5 |
| Zhang, Y | 13 |
| Zhang, M | 7 |
| Ma, Y | 3 |
| Sun, H | 5 |
| Jin, Z | 1 |
| Zheng, H | 2 |
| Jiang, H | 1 |
| Yu, P | 1 |
| Miao, GX | 1 |
| Wang, YD | 2 |
| Yan, ZW | 1 |
| Zhang, LY | 1 |
| Tang, S | 2 |
| Wang, C | 6 |
| Li, YH | 1 |
| Niu, TY | 1 |
| Zhang, YH | 1 |
| Pang, YD | 1 |
| Wang, YX | 1 |
| Kong, WJ | 1 |
| Song, DQ | 1 |
| Zhang, X | 15 |
| Chen, H | 6 |
| Lei, Y | 4 |
| Xu, L | 3 |
| Liu, W | 5 |
| Fan, Z | 1 |
| Ma, Z | 2 |
| Yin, Z | 1 |
| Li, L | 6 |
| Zhu, C | 3 |
| Ma, B | 3 |
| Wu, XD | 2 |
| Huang, S | 1 |
| Shi, Y | 2 |
| Shen, Y | 2 |
| Tu, WC | 1 |
| Leng, Y | 2 |
| Zhao, QS | 1 |
| Xu, H | 1 |
| Zahran, F | 1 |
| Mohamad, A | 1 |
| Zein, N | 1 |
| Cao, XJ | 1 |
| Wu, R | 1 |
| Qian, HY | 1 |
| Chen, X | 3 |
| Zhu, HY | 1 |
| Xu, GY | 1 |
| Sun, YZ | 1 |
| Zhang, PA | 1 |
| Dare, A | 2 |
| Channa, ML | 2 |
| Nadar, A | 2 |
| Zayas-Arrabal, J | 1 |
| Alquiza, A | 1 |
| Rodríguez-de-Yurre, A | 1 |
| Echeazarra, L | 1 |
| Fernández-López, V | 1 |
| Gallego, M | 1 |
| Casis, O | 1 |
| Figueiredo, BS | 1 |
| Ferreira, FBD | 1 |
| Barbosa, AM | 1 |
| Dos Santos, C | 1 |
| Ortsäter, H | 1 |
| Rafacho, A | 1 |
| Han, YC | 1 |
| Tang, SQ | 1 |
| Liu, YT | 1 |
| Li, AM | 1 |
| Zhan, M | 1 |
| Yang, M | 3 |
| Song, N | 1 |
| Zhang, W | 5 |
| Wu, XQ | 1 |
| Peng, CH | 1 |
| Zhang, H | 3 |
| Yang, S | 3 |
| Abdulmalek, S | 1 |
| Eldala, A | 1 |
| Awad, D | 1 |
| Balbaa, M | 2 |
| Azemi, AK | 1 |
| Mokhtar, SS | 1 |
| Sharif, SET | 1 |
| Rasool, AHG | 1 |
| Tombulturk, FK | 1 |
| Todurga-Seven, ZG | 1 |
| Huseyinbas, O | 1 |
| Ozyazgan, S | 1 |
| Ulutin, T | 1 |
| Kanigur-Sultuybek, G | 2 |
| Kang, J | 2 |
| Gao, X | 2 |
| Liu, Z | 6 |
| Chen, C | 1 |
| Luo, D | 2 |
| Mady, OY | 1 |
| Al-Shoubki, AA | 1 |
| Donia, AA | 1 |
| Lee, SJ | 1 |
| Yoon, BS | 1 |
| Hong, JM | 1 |
| Joe, EH | 1 |
| Lee, JS | 1 |
| Perumal, N | 1 |
| Nallappan, M | 1 |
| Shohaimi, S | 1 |
| Kassim, NK | 1 |
| Tee, TT | 1 |
| Cheah, YH | 1 |
| Koroglu Aydın, P | 1 |
| Karabulut-Bulan, O | 3 |
| Bugan, I | 3 |
| Turkyilmaz, IB | 2 |
| Altun, S | 1 |
| Yanardag, R | 8 |
| Zhao, L | 1 |
| Zhang, J | 8 |
| Li, P | 3 |
| Lv, Z | 1 |
| Hou, Y | 4 |
| Li, FZ | 1 |
| Hao, Q | 1 |
| Huang, Z | 2 |
| Li, Q | 3 |
| Liu, D | 3 |
| Wang, P | 1 |
| Cao, W | 1 |
| Deng, W | 1 |
| Wu, K | 2 |
| Su, R | 1 |
| Vadgama, J | 1 |
| Wu, Y | 4 |
| Yang, ML | 1 |
| Lu, C | 1 |
| Fan, ZF | 1 |
| Zhao, TR | 1 |
| Cheng, GG | 1 |
| Cao, JX | 1 |
| Liu, YP | 1 |
| Lule, KO | 1 |
| Akarsu, E | 2 |
| Sayiner, ZA | 2 |
| Lule, NO | 1 |
| Balci, SO | 2 |
| Demirel, C | 2 |
| Bozdag, Z | 2 |
| Korkmaz, M | 2 |
| Yilmaz, I | 2 |
| Yu, XJ | 1 |
| Chen, YM | 1 |
| Liu, XJ | 1 |
| Bai, XJ | 1 |
| Liu, KL | 1 |
| Fu, LY | 1 |
| Gao, HL | 1 |
| Sun, TZ | 1 |
| Shi, XL | 1 |
| Qi, J | 3 |
| Li, Y | 7 |
| Kang, YM | 1 |
| Shehata, NI | 1 |
| Abo Zeid, SM | 1 |
| Abd El Aziz, SA | 1 |
| Abdelgawad, HM | 1 |
| Derkach, KV | 6 |
| Bakhtyukov, AA | 3 |
| Morina, IY | 1 |
| Romanova, IV | 2 |
| Bayunova, LV | 3 |
| Shpakov, AO | 6 |
| Jia, RB | 1 |
| Li, ZR | 1 |
| Lin, L | 2 |
| Zheng, Q | 1 |
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| Jia, Y | 2 |
| Yang, W | 3 |
| Lin, C | 1 |
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| Deng, Z | 1 |
| Gao, P | 2 |
| Yang, Y | 7 |
| Cai, K | 1 |
| Fazle, R | 1 |
| Amir, Z | 1 |
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| Achyut, A | 1 |
| Irfan, U | 1 |
| Shafiq Ur, R | 1 |
| Kang, ZQ | 1 |
| Hu, JL | 1 |
| Chen, MY | 1 |
| Mao, Y | 1 |
| Xie, LF | 1 |
| Yang, N | 1 |
| Liu, T | 2 |
| Huang, WH | 1 |
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| Pan, S | 1 |
| Wang, B | 3 |
| Hong, X | 1 |
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| Bai, J | 1 |
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| Liu, J | 8 |
| Lei, X | 1 |
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| Haddad, M | 2 |
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| Harb, F | 2 |
| Massry, MEL | 1 |
| Azar, S | 1 |
| Sauleau, EA | 2 |
| Eid, AA | 2 |
| Naghibi, M | 1 |
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| Liu, H | 4 |
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| Rajankutty, K | 1 |
| Raghu, KG | 2 |
| Liu, Y | 11 |
| Liu, X | 8 |
| Xiang, M | 2 |
| Zhang, L | 7 |
| Zhu, S | 1 |
| Lu, J | 5 |
| Tang, Q | 1 |
| Cheng, S | 2 |
| Yin, J | 1 |
| Zhong, Q | 1 |
| Liang, M | 1 |
| Lin, Q | 1 |
| Wang, H | 4 |
| Wang, W | 6 |
| Wang, L | 6 |
| Hu, X | 4 |
| Bei, W | 1 |
| Guo, J | 4 |
| Widyawati, T | 1 |
| Yusoff, NA | 1 |
| Bello, I | 1 |
| Asmawi, MZ | 3 |
| Ahmad, M | 3 |
| Ramadan, NM | 1 |
| Elmasry, K | 1 |
| Elsayed, HRH | 1 |
| El-Mesery, A | 1 |
| Eraky, SM | 1 |
| Sun, S | 1 |
| Dawuti, A | 1 |
| Gong, D | 1 |
| Wang, R | 1 |
| Yuan, T | 1 |
| Wang, S | 6 |
| Xing, C | 1 |
| Lu, Y | 2 |
| Du, G | 1 |
| Fang, L | 2 |
| Wang, X | 12 |
| Mo, Y | 1 |
| Zhao, D | 3 |
| Dai, L | 1 |
| Chellian, J | 3 |
| Mak, KK | 3 |
| Chellappan, DK | 2 |
| Krishnappa, P | 2 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Dipeptidyl-4 Inhibitors in Reducing Stroke Severity, From the Health Insurance Review and Assessment Service Database[NCT05817097] | 22,119 participants (Anticipated) | Observational | 2023-08-31 | Not yet recruiting | |||
| Modulation of Gut Microbiota to Enhance Health and Immunity of Vulnerable Individuals During COVID-19 Pandemic[NCT04884776] | 453 participants (Actual) | Interventional | 2021-06-01 | Active, not recruiting | |||
| Efficacy and Safety of Metformin Glycinate Compared to Metformin Hydrochloride on the Progression of Type 2 Diabetes[NCT04943692] | Phase 3 | 500 participants (Anticipated) | Interventional | 2021-08-31 | Suspended (stopped due to Administrative decision of the investigation direction) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for metformin and Alloxan Diabetes
| Article | Year |
|---|---|
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Hybrid drug combination: Combination of ferulic acid and metformin as anti-diabetic therapy.
Topics: Animals; Antioxidants; Coumaric Acids; Diabetes Mellitus, Experimental; Drug Synergism; Drug Therapy | 2017 |
A preclinical overview of metformin for the treatment of type 2 diabetes.
Topics: Animals; Biomarkers; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Drug | 2018 |
Should we be concerned about thyroid cancer in patients taking glucagon-like peptide 1 receptor agonists?
Topics: Animals; Blood Glucose; Contraindications; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type | 2015 |
3 trials available for metformin and Alloxan Diabetes
| Article | Year |
|---|---|
Metformin and Bee Venom: a Comparative Detection of Histological Alteration of the Pancreas and Systemic Inflammatory Markers in Diabetic Mice.
Topics: Alloxan; Animals; Bee Venoms; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Typ | 2022 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Thymoquinone with Metformin Decreases Fasting, Post Prandial Glucose, and HbA1c in Type 2 Diabetic Patients.
Topics: Administration, Oral; Adult; Animals; Benzoquinones; Blood Glucose; Diabetes Mellitus, Experimental; | 2021 |
615 other studies available for metformin and Alloxan Diabetes
| Article | Year |
|---|---|
Antihyperglycemic N-sulfonyl-1a,2,6,6a-tetrahydro-1H,4H- [1,3]dioxepino[5,6-b]azirines: synthesis, X-ray structure analysis, conformational behavior, quantitative structure-property relationships, and quantitative structure-activity relationships.
Topics: Animals; Azirines; Computer Graphics; Diabetes Mellitus, Experimental; Female; Hypoglycemic Agents; | 1995 |
Antihyperglycemic activity of phenolics from Pterocarpus marsupium.
Topics: Animals; Benzofurans; Blood Glucose; Body Weight; Cresols; Diabetes Mellitus, Experimental; Female; | 1997 |
Synthesis and hypoglycemic evaluation of substituted pyrazole-4-carboxylic acids.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Hypoglyce | 2002 |
Novel substituted naphthalen-1-yl-methanone derivatives as anti-hyperglycemic agents.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Male; Naphthalenes; Ra | 2006 |
Chalcone based aryloxypropanolamines as potential antihyperglycemic agents.
Topics: Animals; Chalones; Diabetes Mellitus, Experimental; Hyperglycemia; Hypoglycemic Agents; Indicators a | 2007 |
Antihyperglycemic and antidyslipidemic agent from Aegle marmelos.
Topics: Adrenergic beta-3 Receptor Agonists; Adrenergic beta-Agonists; Aegle; Animals; Blood Glucose; Choles | 2007 |
Synthesis and in vivo antihyperglycemic activity of nature-mimicking furanyl-2-pyranones in STZ-S model.
Topics: Animals; Chemistry, Pharmaceutical; Diabetes Mellitus, Experimental; Drug Design; Furans; Hyperglyce | 2007 |
Synthesis and antihyperglycemic activity of novel N-acyl-2-arylethylamines and N-acyl-3-coumarylamines.
Topics: Acylation; Animals; Blood Glucose; Coumaric Acids; Diabetes Mellitus, Experimental; Ethylamines; Hyp | 2008 |
Novel 2-aryl-naphtho[1,2-d]oxazole derivatives as potential PTP-1B inhibitors showing antihyperglycemic activities.
Topics: Animals; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Hypoglycemic Agents; Lipids; Mice; Oxaz | 2009 |
Synthesis of alpha-amyrin derivatives and their in vivo antihyperglycemic activity.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Magnetic Resonance Spe | 2009 |
Coagulanolide, a withanolide from Withania coagulans fruits and antihyperglycemic activity.
Topics: Animals; Chemistry, Pharmaceutical; Diabetes Mellitus, Experimental; Hyperglycemia; Hypoglycemic Age | 2008 |
Synthesis of protein tyrosine phosphatase 1B inhibitors: model validation and docking studies.
Topics: Animals; Binding Sites; Crystallography, X-Ray; Diabetes Mellitus, Experimental; Drug Delivery Syste | 2009 |
5,6-Diarylanthranilo-1,3-dinitriles as a new class of antihyperglycemic agents.
Topics: Animals; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Male; Rats; Rats, Sprague-Dawley | 2009 |
Design and synthesis of 3,5-diarylisoxazole derivatives as novel class of anti-hyperglycemic and lipid lowering agents.
Topics: Animals; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dos | 2009 |
Synthesis of novel triterpenoid (lupeol) derivatives and their in vivo antihyperglycemic and antidyslipidemic activity.
Topics: Animals; Anti-Inflammatory Agents; Body Weight; Chemistry, Pharmaceutical; Cricetinae; Diabetes Mell | 2009 |
Design and synthesis of 2,4-disubstituted polyhydroquinolines as prospective antihyperglycemic and lipid modulating agents.
Topics: Animals; Diabetes Mellitus, Experimental; Drug Design; Dyslipidemias; Glycogen Phosphorylase; Hypogl | 2010 |
Antihyperglycemic effect of catalpol in streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucosides; Glycogen; Hepatocytes; Hypoglyc | 2010 |
Design, synthesis and docking studies on phenoxy-3-piperazin-1-yl-propan-2-ol derivatives as protein tyrosine phosphatase 1B inhibitors.
Topics: Animals; Binding Sites; Catalytic Domain; Computer Simulation; Diabetes Mellitus, Experimental; Dise | 2010 |
Synthesis and antihyperglycemic activity of phenolic C-glycosides.
Topics: Animals; Blood Glucose; Cell Line; Chalcones; Diabetes Mellitus, Experimental; Glucosides; Hypoglyce | 2011 |
Glucose-lowering activity of novel tetrasaccharide glyceroglycolipids from the fruits of Cucurbita moschata.
Topics: Animals; Blood Glucose; Cucurbita; Diabetes Mellitus, Experimental; Fruit; Glycolipids; Hypoglycemic | 2011 |
Hypoglycemic diterpenoids from Tinospora crispa.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diterpenes; Hypoglycemic Agents; Mice; Mole | 2012 |
Synthesis of propiophenone derivatives as new class of antidiabetic agents reducing body weight in db/db mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Eating; Hypoglycemic Agents; Hypolipidemic | 2012 |
Flavone-based novel antidiabetic and antidyslipidemic agents.
Topics: Animals; Biological Availability; Cholesterol; Cricetinae; Diabetes Mellitus, Experimental; Dose-Res | 2012 |
Antihyperglycemic effect of syringaldehyde in streptozotocin-induced diabetic rats.
Topics: Animals; Benzaldehydes; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Response Relationship, | 2012 |
Synthesis and anti-hyperglycemic activity of hesperidin derivatives.
Topics: Administration, Oral; alpha-Glucosidases; Animals; Blood Glucose; Diabetes Mellitus, Experimental; F | 2012 |
Discovery of SAR184841, a potent and long-lasting inhibitor of 11β-hydroxysteroid dehydrogenase type 1, active in a physiopathological animal model of T2D.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Adamantane; Animals; Diabetes Mellitus, Experimental; D | 2013 |
Discovery of 3-(4-methanesulfonylphenoxy)-N-[1-(2-methoxy-ethoxymethyl)-1H-pyrazol-3-yl]-5-(3-methylpyridin-2-yl)-benzamide as a novel glucokinase activator (GKA) for the treatment of type 2 diabetes mellitus.
Topics: Animals; Benzamides; Blood Glucose; Cell Line; Diabetes Mellitus, Experimental; Diabetes Mellitus, T | 2014 |
Design, synthesis and biological evaluation of GY3-based derivatives for anti-type 2 diabetes activity.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Drug Design; Hep G2 Cells; Huma | 2015 |
Synthesis of new thiazolylmethoxyphenyl pyrimidines and antihyperglycemic evaluation of the pyrimidines, analogues isoxazolines and pyrazolines.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Drug Design; Glucose Tolerance Test; Hypogl | 2015 |
Naturally Occurring Carbazole Alkaloids from Murraya koenigii as Potential Antidiabetic Agents.
Topics: Alkaloids; Animals; Blood Glucose; Carbazoles; Diabetes Mellitus, Experimental; Glucose; Glucose Tra | 2016 |
Design, synthesis and structure-activity relationship studies of novel free fatty acid receptor 1 agonists bearing amide linker.
Topics: Amides; Animals; Area Under Curve; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus | 2017 |
Surrogating and redirection of pyrazolo[1,5-a]pyrimidin-7(4H)-one core, a novel class of potent and selective DPP-4 inhibitors.
Topics: Animals; Binding Sites; Catalytic Domain; Cell Survival; Diabetes Mellitus, Experimental; Dipeptidyl | 2018 |
Design, synthesis and biological evaluation of novel pyrimidinedione derivatives as DPP-4 inhibitors.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Dipepti | 2018 |
New insights into the biological activities of Chrysanthemum morifolium: Natural flavonoids alleviate diabetes by targeting α-glucosidase and the PTP-1B signaling pathway.
Topics: Animals; Cell Line, Tumor; Cholesterol; Chrysanthemum; Cricetulus; Diabetes Mellitus, Experimental; | 2019 |
Synthesis, in vitro ADME profiling and in vivo pharmacological evaluation of novel glycogen phosphorylase inhibitors.
Topics: Animals; Blood Glucose; Cell Proliferation; Diabetes Mellitus, Experimental; Dose-Response Relations | 2020 |
Structure-activity relationship and hypoglycemic activity of tricyclic matrines with advantage of treating diabetic nephropathy.
Topics: Alkaloids; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Female; Hep G2 Cells; H | 2020 |
Multifunctional agents based on benzoxazolone as promising therapeutic drugs for diabetic nephropathy.
Topics: Aldehyde Reductase; Animals; Antioxidants; Benzoxazoles; Diabetes Mellitus, Experimental; Diabetic N | 2021 |
Design, synthesis and structural-activity relationship studies of phanginin A derivatives for regulating SIK1-cAMP/CREB signaling to suppress hepatic gluconeogenesis.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Gluconeogenesis; Liver; Mice; P | 2022 |
Novel Hydroxychalcone-Based Dual Inhibitors of Aldose Reductase and α-Glucosidase as Potential Therapeutic Agents against Diabetes Mellitus and Its Complications.
Topics: Aldehyde Reductase; alpha-Glucosidases; Animals; Antioxidants; Diabetes Mellitus, Experimental; Enzy | 2022 |
Bee venom ameliorates cardiac dysfunction in diabetic hyperlipidemic rats.
Topics: Animals; Atorvastatin; Bee Venoms; Diabetes Mellitus, Experimental; Diet, High-Fat; Heart; Hyperlipi | 2021 |
Metformin attenuates diabetic neuropathic pain via AMPK/NF-κB signaling pathway in dorsal root ganglion of diabetic rats.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Experimental; | 2021 |
L-ergothioneine and metformin alleviates liver injury in experimental type-2 diabetic rats via reduction of oxidative stress, inflammation, and hypertriglyceridemia.
Topics: Administration, Oral; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Drug Therapy, Combina | 2021 |
Kv1.3 Channel Blockade Improves Inflammatory Profile, Reduces Cardiac Electrical Remodeling, and Prevents Arrhythmia in Type 2 Diabetic Rats.
Topics: Animals; Arrhythmias, Cardiac; Atrial Remodeling; Cytokines; Diabetes Mellitus, Experimental; Diabet | 2023 |
Coadministration of sitagliptin or metformin has no major impact on the adverse metabolic outcomes induced by dexamethasone treatment in rats.
Topics: Animals; Blood Glucose; Body Weight; Dexamethasone; Diabetes Mellitus, Experimental; Feeding Behavio | 2021 |
AMPK agonist alleviate renal tubulointerstitial fibrosis via activating mitophagy in high fat and streptozotocin induced diabetic mice.
Topics: 8-Hydroxy-2'-Deoxyguanosine; AMP-Activated Protein Kinases; Animals; Blood Glucose; Blood Urea Nitro | 2021 |
Ameliorative effect of curcumin and zinc oxide nanoparticles on multiple mechanisms in obese rats with induced type 2 diabetes.
Topics: Animals; Antioxidants; Blood Glucose; Curcumin; Diabetes Mellitus, Experimental; Diabetes Mellitus, | 2021 |
Topics: Acanthaceae; Animals; Atherosclerosis; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; D | 2021 |
Topical application of metformin accelerates cutaneous wound healing in streptozotocin-induced diabetic rats.
Topics: Administration, Topical; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diseas | 2022 |
Metformin inhibits tumor growth and affects intestinal flora in diabetic tumor-bearing mice.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Correlation of Data; Diabetes Mellitus, Experiment | 2021 |
An Industrial Procedure for Pharmacodynamic Improvement of Metformin HCl via Granulation with Its Paracellular Pathway Enhancer Using Factorial Experimental Design.
Topics: Animals; Blood Glucose; Crystallization; Diabetes Mellitus, Experimental; Drug Compounding; Hexoses; | 2021 |
Effects of co-administration of metformin and evogliptin on cerebral infarct volume in the diabetic rat.
Topics: Animals; Brain Chemistry; Cerebral Infarction; Cerebrovascular Circulation; Diabetes Mellitus, Exper | 2022 |
Synergistic antidiabetic activity of Taraxacum officinale (L.) Weber ex F.H.Wigg and Momordica charantia L. polyherbal combination.
Topics: Animals; Blood Glucose; Cell Line; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Drug | 2022 |
The protective effect of metformin against testicular damage in diabetes and prostate cancer model.
Topics: Animals; Diabetes Mellitus, Experimental; Humans; Male; Metformin; Oxidative Stress; Prostate; Prost | 2022 |
Metformin improves cognitive impairment in diabetic mice induced by a combination of streptozotocin and isoflurane anesthesia.
Topics: Anesthesia; Animals; Cognitive Dysfunction; Diabetes Mellitus, Experimental; Disease Models, Animal; | 2021 |
The protective effect of Metformin/Donepezil in diabetic mice brain: evidence from bioinformatics analysis and experiments.
Topics: Animals; Apoptosis; Brain; Cholinesterase Inhibitors; Computational Biology; Diabetes Mellitus, Expe | 2021 |
A Novel Metabolic Reprogramming Strategy for the Treatment of Diabetes-Associated Breast Cancer.
Topics: Animals; Antineoplastic Agents, Alkylating; Breast Neoplasms; Diabetes Mellitus, Experimental; Disea | 2022 |
Hypoglycemic and hypolipidemic effects of Epigynum auritum in high fat diet and streptozotocin-induced diabetic rats.
Topics: Animals; Apocynaceae; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Die | 2022 |
The effects of metformin, pioglitazone, exenatide and exercise on fatty liver in obese diabetic rats: the role of IRS-1 and SOCS-3 molecules.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Exenatide; Insulin Receptor Sub | 2022 |
Beneficial effects of metformin supplementation in hypothalamic paraventricular nucleus and arcuate nucleus of type 2 diabetic rats.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Astrocytes; Blood Glucose; Body Weight; Diabetes Mellitus, | 2022 |
Mitigation of streptozotocin-induced alterations by natural agents via upregulation of PDX1 and Ins1 genes in male rats.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Humans; Hypoglyce | 2022 |
Comparative Study of the Restoring Effect of Metformin, Gonadotropin, and Allosteric Agonist of Luteinizing Hormone Receptor on Spermatogenesis in Male Rats with Streptozotocin-Induced Type 2 Diabetes Mellitus.
Topics: Animals; Chorionic Gonadotropin; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Male; M | 2022 |
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; | 2022 |
A pH-responsive hyaluronic acid hydrogel for regulating the inflammation and remodeling of the ECM in diabetic wounds.
Topics: Animals; Diabetes Mellitus, Experimental; Hyaluronic Acid; Hydrogels; Hydrogen-Ion Concentration; In | 2022 |
Detailed approach toward the anti-hyperglycemic potential of Sterculia diversifolia G. Don against alloxan-induced in vivo hyperglycemia model.
Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Humans; Hyperglycemia; Hypoglycemi | 2022 |
Effects of Capsaicin on the Hypoglycemic Regulation of Metformin and Gut Microbiota Profiles in Type 2 Diabetic Rats.
Topics: Animals; Blood Glucose; Capsaicin; Cytokines; Diabetes Mellitus, Experimental; Diabetes Mellitus, Ty | 2022 |
Co-administration of hydrogen and metformin exerts cardioprotective effects by inhibiting pyroptosis and fibrosis in diabetic cardiomyopathy.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Fibrosis; Hydrogen; Metformin; | 2022 |
Dendrobium nobile Lindl polysaccharides improve testicular spermatogenic function in streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Dendrobium; Diabetes Mellitus, Experimental; Male; Metformin; Polysaccharide | 2022 |
Activation of 20-HETE Synthase Triggers Oxidative Injury and Peripheral Nerve Damage in Type 2 Diabetic Mice.
Topics: AMP-Activated Protein Kinases; Animals; Cytochrome P-450 CYP4A; Diabetes Mellitus, Experimental; Dia | 2022 |
The effects of metformin and forskolin on sperm quality parameters and sexual hormones in type II diabetic male rats.
Topics: Animals; bcl-2-Associated X Protein; Blood Glucose; Colforsin; Diabetes Mellitus, Experimental; Diab | 2022 |
Effects of Combined
Topics: Animals; Aryldialkylphosphatase; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, | 2022 |
Potential Role of Mitochondria as Modulators of Blood Platelet Activation and Reactivity in Diabetes and Effect of Metformin on Blood Platelet Bioenergetics and Platelet Activation.
Topics: Animals; Blood Platelets; Diabetes Mellitus, Experimental; Energy Metabolism; Metformin; Mitochondri | 2022 |
Evaluation of metformin performance on alloxan-induced diabetic rabbits.
Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Glutathione; Hypoglycemic Agents; Metformin; Rabb | 2022 |
Efficacy of Sitagliptin on Nonalcoholic Fatty Liver Disease in High-fat-diet-fed Diabetic Mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; | 2022 |
Effects of combination treatment with metformin and berberine on hypoglycemic activity and gut microbiota modulation in db/db mice.
Topics: Animals; Berberine; Chromatography, Liquid; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type | 2022 |
Therapeutic Effect of P-Cymene on Lipid Profile, Liver Enzyme, and Akt/Mtor Pathway in Streptozotocin-Induced Diabetes Mellitus in Wistar Rats.
Topics: Animals; Antioxidants; Blood Glucose; Cholesterol; Cymenes; Diabetes Mellitus, Experimental; Hypogly | 2022 |
Anti-inflammatory, anti-oxidant and anti-apoptotic effects of olive leaf extract in cardiac tissue of diabetic rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Diabetes Mellitus, Experimental; Metformin; Olea; O | 2022 |
[Dihydromyricetin improves cardiac insufficiency by inhibiting HMGB1 in diabetic rats].
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Flavonols; Heart Failure; HMGB1 | 2022 |
[Fucoxanthin regulates Nrf2/Keap1 signaling to alleviate myocardial hypertrophy in diabetic rats].
Topics: Animals; Antioxidants; Atrial Natriuretic Factor; Cardiomegaly; Diabetes Mellitus, Experimental; Fib | 2022 |
Effects of antidiabetic agents on Alzheimer's disease biomarkers in experimentally induced hyperglycemic rat model by streptozocin.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases | 2022 |
Ferulic acid mitigates diabetic cardiomyopathy via modulation of metabolic abnormalities in cardiac tissues of diabetic rats.
Topics: Acetylcholinesterase; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Diabete | 2023 |
Metformin and Gegen Qinlian Decoction boost islet α-cell proliferation of the STZ induced diabetic rats.
Topics: Animals; Cell Proliferation; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Drugs, Chin | 2022 |
Assessment of In Vitro Tests as Predictors of the Antioxidant Effects of Insulin, Metformin, and Taurine in the Brain of Diabetic Rats.
Topics: Animals; Antioxidants; Blood Glucose; Brain; Diabetes Mellitus, Experimental; Glutathione; Hyperglyc | 2022 |
Linagliptin in Combination With Metformin Ameliorates Diabetic Osteoporosis Through Modulating BMP-2 and Sclerostin in the High-Fat Diet Fed C57BL/6 Mice.
Topics: Animals; Biomarkers; Body Weight; Calcium; Cytokines; Diabetes Mellitus, Experimental; Diet, High-Fa | 2022 |
Preferential effect of Montelukast on Dapagliflozin: Modulation of IRS-1/AKT/GLUT4 and ER stress response elements improves insulin sensitivity in soleus muscle of a type-2 diabetic rat model.
Topics: Acetates; Animals; Antioxidants; Benzhydryl Compounds; Blood Glucose; Cyclopropanes; Diabetes Mellit | 2022 |
Hypoglycemic, Hypolipidemic and Antioxidant Potentials of Ethanolic Stem Bark Extract of Anacardium occidentale in Streptozotocin-Induced Diabetic Rats.
Topics: Anacardium; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Glutathione; Hypo | 2022 |
Rapamycin/metformin co-treatment normalizes insulin sensitivity and reduces complications of metabolic syndrome in type 2 diabetic mice.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Fatty Liver; Hyperglycemia; Hyp | 2022 |
Metformin improves neurobehavioral impairments of streptozotocin-treated and western diet-fed mice: Beyond glucose-lowering effects.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitu | 2023 |
Biochemical and tissue physiopathological evaluation of the preclinical efficacy of Solanum torvum Swartz leaves for treating oxidative impairment in rats administered a β-cell-toxicant (STZ).
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Metformin; Oxidative Stress; | 2022 |
Metformin prevents morphine-induced apoptosis in rats with diabetic neuropathy: a possible mechanism for attenuating morphine tolerance.
Topics: Analgesics; Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Diabetes Mellitus, Experiment | 2022 |
The consumption of sea buckthorn (Hippophae rhamnoides L.) effectively alleviates type 2 diabetes symptoms in spontaneous diabetic rats.
Topics: Animals; Antioxidants; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Frui | 2022 |
Tert-butylhydroquinone Mitigates Renal Dysfunction in Pregnant Diabetic Rats
Topics: Animals; Antioxidants; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental; Diabetes, Gestat | 2023 |
Cinnamic acid is beneficial to diabetic cardiomyopathy via its cardioprotective, anti-inflammatory, anti-dyslipidemia, and antidiabetic properties.
Topics: Animals; Anti-Inflammatory Agents; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Hypog | 2022 |
Exercise and Metformin Intervention Prevents Lipotoxicity-Induced Hepatocyte Apoptosis by Alleviating Oxidative and ER Stress and Activating the AMPK/Nrf2/HO-1 Signaling Pathway in db/db Mice.
Topics: AMP-Activated Protein Kinases; Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Blood G | 2022 |
Fufang-zhenzhu-tiaozhi formula protects islet against injury and promotes β cell regeneration in diabetic mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Eosine Yellowish | 2023 |
Bioactivity-Guided Fractionation and Identification of Antidiabetic Compound of
Topics: Animals; Blood Glucose; Chloroform; Cholesterol; Diabetes Mellitus, Experimental; Hypoglycemic Agent | 2022 |
The hepatoprotective effects of n3-polyunsaturated fatty acids against non-alcoholic fatty liver disease in diabetic rats through the FOXO1/PPARα/GABARAPL1 signalling pathway.
Topics: Animals; Diabetes Mellitus, Experimental; Diet, High-Fat; Fatty Acids; Fatty Acids, Omega-3; Insulin | 2022 |
Puerarin-V Improve Mitochondrial Respiration and Cardiac Function in a Rat Model of Diabetic Cardiomyopathy via Inhibiting Pyroptosis Pathway through P2X7 Receptors.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Metformin; Myocardium; Pyroptos | 2022 |
Pharmacodynamic Interactions between Puerarin and Metformin in Type-2 Diabetic Rats.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Isoflavones; Metformin; Rats | 2022 |
Quercetin and metformin synergistically reverse endothelial dysfunction in the isolated aorta of streptozotocin-nicotinamide- induced diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Endothelium, Vascular; Hypoglycemic Agents; Metformin; Nia | 2022 |
Quercetin and metformin synergistically reverse endothelial dysfunction in the isolated aorta of streptozotocin-nicotinamide- induced diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Endothelium, Vascular; Hypoglycemic Agents; Metformin; Nia | 2022 |
Quercetin and metformin synergistically reverse endothelial dysfunction in the isolated aorta of streptozotocin-nicotinamide- induced diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Endothelium, Vascular; Hypoglycemic Agents; Metformin; Nia | 2022 |
Quercetin and metformin synergistically reverse endothelial dysfunction in the isolated aorta of streptozotocin-nicotinamide- induced diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Endothelium, Vascular; Hypoglycemic Agents; Metformin; Nia | 2022 |
Metformin suppresses LRG1 and TGFβ1/ALK1-induced angiogenesis and protects against ultrastructural changes in rat diabetic nephropathy.
Topics: Activins; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glycoproteins; Kidney; M | 2023 |
Metformin suppresses LRG1 and TGFβ1/ALK1-induced angiogenesis and protects against ultrastructural changes in rat diabetic nephropathy.
Topics: Activins; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glycoproteins; Kidney; M | 2023 |
Metformin suppresses LRG1 and TGFβ1/ALK1-induced angiogenesis and protects against ultrastructural changes in rat diabetic nephropathy.
Topics: Activins; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glycoproteins; Kidney; M | 2023 |
Metformin suppresses LRG1 and TGFβ1/ALK1-induced angiogenesis and protects against ultrastructural changes in rat diabetic nephropathy.
Topics: Activins; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glycoproteins; Kidney; M | 2023 |
Metformin regulates the effects of IR and IGF-1R methylation on mast cell activation and airway reactivity in diabetic rats with asthma through miR-152-3p/DNMT1 axis.
Topics: Animals; Asthma; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Mast Cells; Metformin; | 2023 |
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Fruit; Hypoglyce | 2023 |
Protective effects of cinnamon on acetylcholinesterase activity and memory dysfunction in diabetic rats.
Topics: Acetylcholinesterase; Animals; Antioxidants; Cinnamomum zeylanicum; Diabetes Mellitus, Experimental; | 2023 |
Effects of antidiabetics and exercise therapy on suppressors of cytokine signaling-1, suppressors of cytokine signaling-3, and insulin receptor substrate-1 molecules in diabetes and obesity.
Topics: Animals; Cytokines; Diabetes Mellitus, Experimental; Exenatide; Exercise Therapy; Humans; Hypoglycem | 2023 |
In Vivo Evaluation of Nanoemulsion Formulations for Metformin and Repaglinide Alone and Combination.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Hypoglycemic Age | 2023 |
Crude extract from
Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Euphorbia; Gliclazide; Glyburide; | 2023 |
New Treatment for Type 2 Diabetes Mellitus Using a Novel Bipyrazole Compound.
Topics: AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; | 2023 |
Co-administration of metformin and/or glibenclamide with losartan reverse N
Topics: Animals; Antihypertensive Agents; Blood Pressure; Diabetes Mellitus, Experimental; Esters; Glyburide | 2023 |
The effects of endurance exercise and metformin on memory impairment caused by diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Exercise Therapy; Glucose; Humans; Male; Memory Disorders; | 2023 |
Green synthesis and characterization of silver nanoparticles for reducing the damage to sperm parameters in diabetic compared to metformin.
Topics: Animals; Diabetes Mellitus, Experimental; Green Chemistry Technology; Male; Metal Nanoparticles; Met | 2023 |
The role of mosapride and levosulpiride in gut function and glycemic control in diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Gastroparesis; G | 2023 |
Therapeutic Potential of Metformin-preconditioned Mesenchymal Stem Cells for Pancreatic Regeneration.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Insulin; Mesenchymal Stem Cell | 2023 |
Discovery of the cysteine dynamics during the development and treatment of diabetic process by fluorescent imaging.
Topics: Animals; Cysteine; Diabetes Mellitus, Experimental; Fluorescent Dyes; HeLa Cells; Humans; Metformin; | 2023 |
Metformin promotes osteogenic differentiation and prevents hyperglycaemia-induced osteoporosis by suppressing PPARγ expression.
Topics: AMP-Activated Protein Kinases; Animals; Cell Differentiation; Diabetes Mellitus, Experimental; Hyper | 2023 |
The Emerging Importance of Cirsimaritin in Type 2 Diabetes Treatment.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; | 2023 |
A Novel Drug Delivery System: Hyodeoxycholic Acid-Modified Metformin Liposomes for Type 2 Diabetes Treatment.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Drug Delivery Sy | 2023 |
Potential therapeutic effect of medium chain triglyceride oil in ameliorating diabetic liver injury in a streptozotocin-induced diabetic murine model.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Hypoglycemic Agents | 2023 |
Ameliorative effect of Arabic gum Acacia and mori extracts in streptozotocin-induced diabetic rats: implications of Cas-3 and TGF-β.
Topics: Acacia; Animals; Antioxidants; Blood Glucose; Caspase 3; Diabetes Mellitus, Experimental; Gum Arabic | 2023 |
The ameliorative effect of zinc acetate with caffeic acid in the animal model of type 2 diabetes.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Hy | 2023 |
Dihydromyricetin promotes GLP-1 release and glucose uptake by STC-1 cells and enhances the effects of metformin upon STC-1 cells and diabetic mouse model.
Topics: AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Experimental; Glucagon-Like Peptide 1; Gl | 2023 |
Metformin and Canagliflozin Are Equally Renoprotective in Diabetic Kidney Disease but Have No Synergistic Effect.
Topics: Animals; Canagliflozin; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Hyperglycemia; Kidn | 2023 |
Role of serum- and glucocorticoid-inducible kinase 1 in the regulation of hepatic gluconeogenesis.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucocorticoids; Gluconeogenesi | 2023 |
Portulaca oleracea L. (purslane) improves the anti-inflammatory, antioxidant and autophagic actions of metformin in the hippocampus of diabetic demented rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cytokines; Diabetes Mellitus, Experimental; Hippoca | 2023 |
Oxidative brain and cerebellum injury in diabetes and prostate cancer model: Protective effect of metformin.
Topics: Acetylcholinesterase; Animals; Antioxidants; Brain; Cerebellum; Diabetes Mellitus, Experimental; Glu | 2023 |
Metformin regulates bone marrow stromal cells to accelerate bone healing in diabetic mice.
Topics: Animals; Bony Callus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Fractures, Bone; M | 2023 |
The Hypoglycemic and Hypolipidemic Effects of Polyphenol-Rich Strawberry Juice on Diabetic Rats.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Fragaria; Humans; Hypoglycemi | 2023 |
A polysaccharide NAP-3 from Naematelia aurantialba: Structural characterization and adjunctive hypoglycemic activity.
Topics: Adjuvants, Immunologic; Animals; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Insulins; Met | 2023 |
Influence of rutin and its combination with metformin on vascular functions in type 1 diabetes.
Topics: Acetylcholine; Animals; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental; Diabetes Mellit | 2023 |
Vitamin D3 alleviates lung fibrosis of type 2 diabetic rats via SIRT3 mediated suppression of pyroptosis.
Topics: Animals; Apoptosis; Blood Glucose; Body Weight; Cholecalciferol; Diabetes Mellitus, Experimental; Di | 2023 |
Gallic acid improves the metformin effects on diabetic kidney disease in mice.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Gallic | 2023 |
Potential molecular mechanisms underlying the ameliorative effect of Cola nitida (Vent.) Schott & Endl. on insulin resistance in rat skeletal muscles.
Topics: Animals; Cola; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucose Transporter Type | 2024 |
Dapagliflozin and metformin in combination ameliorates diabetic nephropathy by suppressing oxidative stress, inflammation, and apoptosis and activating autophagy in diabetic rats.
Topics: Animals; Apoptosis; Autophagy; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic | 2024 |
Dalbergiella welwitschia (Baker) Baker f. alkaloid-rich extracts attenuate liver damage in streptozotocin-induced diabetic rats.
Topics: Alkaloids; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Hypoglycemic Agents | 2023 |
Protective effects of metformin on pancreatic β-cell ferroptosis in type 2 diabetes in vivo.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Ferroptosis; Humans; Insulin; I | 2023 |
Synergistic effect of nano-selenium and metformin on type 2 diabetic rat model: Diabetic complications alleviation through insulin sensitivity, oxidative mediators and inflammatory markers.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Drug Synergism; H | 2019 |
Taurine Improves the Actions of Metformin and Lovastatin on Plasma Markers of Carbohydrate and Lipid Dysfunction of Diabetic Rats.
Topics: Animals; Blood Glucose; Carbohydrates; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Hypolip | 2019 |
Stem cells and metformin synergistically promote healing in experimentally induced cutaneous wound injury in diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal S | 2019 |
Metformin suppresses aortic ultrastrucural damage and hypertension induced by diabetes: a potential role of advanced glycation end products.
Topics: Animals; Antioxidants; Aorta; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High | 2019 |
Dietary Supplementation of Methyl Donor l-Methionine Alters Epigenetic Modification in Type 2 Diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dietary Supplements; DNA (Cytos | 2019 |
Effects of naringenin on vascular changes in prolonged hyperglycaemia in fructose-STZ diabetic rat model.
Topics: Animals; Diabetes Mellitus, Experimental; Drug Synergism; Flavanones; Fructose; Hyperglycemia; Lipid | 2019 |
Effects of berberine and metformin on intestinal inflammation and gut microbiome composition in db/db mice.
Topics: Animals; Berberine; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, | 2019 |
Hypoglycemic effects and biochemical mechanisms of Pea oligopeptide on high-fat diet and streptozotocin-induced diabetic mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; | 2019 |
BÜCHI nano spray dryer B-90: a promising technology for the production of metformin hydrochloride-loaded alginate-gelatin nanoparticles.
Topics: Alginates; Animals; Blood Glucose; Delayed-Action Preparations; Diabetes Mellitus, Experimental; Dia | 2019 |
Effects of metformin, acarbose, and sitagliptin monotherapy on gut microbiota in Zucker diabetic fatty rats.
Topics: Acarbose; Animals; Bacteria; Biomarkers; Blood Glucose; Diabetes Mellitus, Experimental; Feces; Gast | 2019 |
Metformin alleviates oxidative stress and enhances autophagy in diabetic kidney disease via AMPK/SIRT1-FoxO1 pathway.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Cells, Cultured; Diabetes Mellitus, Experimental; | 2020 |
Unmasking the interplay between mTOR and Nox4: novel insights into the mechanism connecting diabetes and cancer.
Topics: AMP-Activated Protein Kinases; Animals; Antibiotics, Antineoplastic; Blood Glucose; Caco-2 Cells; Di | 2019 |
Combination of honey with metformin enhances glucose metabolism and ameliorates hepatic and nephritic dysfunction in STZ-induced diabetic mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucose; Honey; | 2019 |
Preclinical and clinical results regarding the effects of a plant-based antidiabetic formulation versus well established antidiabetic molecules.
Topics: Aged; Animals; Blood Glucose; Brain; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Fem | 2019 |
Co-administration of omega-3 fatty acids and metformin showed more desirable effects than the single therapy on indices of bone mineralisation but not gluco-regulatory and antioxidant markers in diabetic rats.
Topics: Animals; Antioxidants; Biomarkers; Bone and Bones; Calcification, Physiologic; Calcium; Diabetes Mel | 2020 |
Synergistic effect of novel chitosan combined metformin drug on streptozotocin-induced diabetes mellitus rat.
Topics: alpha-Amylases; Animals; Blood Glucose; Chitosan; Diabetes Mellitus, Experimental; Drug Synergism; I | 2020 |
Aqueous extract of Digitaria exilis grains ameliorate diabetes in streptozotocin-induced diabetic male Wistar rats.
Topics: Animals; Diabetes Mellitus, Experimental; Digitaria; Dose-Response Relationship, Drug; Hexokinase; H | 2020 |
Malaysian propolis and metformin mitigate subfertility in streptozotocin-induced diabetic male rats by targeting steroidogenesis, testicular lactate transport, spermatogenesis and mating behaviour.
Topics: Animals; Diabetes Mellitus, Experimental; Fertility; Infertility, Male; Lactic Acid; Male; Metformin | 2020 |
Beneficial effects of combination therapy of phloretin and metformin in streptozotocin-induced diabetic rats and improved insulin sensitivity in vitro.
Topics: Adipose Tissue; Animals; Diabetes Mellitus, Experimental; Glucose Transporter Type 4; Insulin Recept | 2020 |
The Haematological Effects of Oleanolic Acid in Streptozotocin-Induced Diabetic Rats: Effects on Selected Markers.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Erythrocyte Count; Erythrocyte Indices; Ery | 2019 |
Blockade of high mobility group box 1 involved in the protective of curcumin on myocardial injury in diabetes in vivo and in vitro.
Topics: Animals; Cardiotonic Agents; Caspase 1; Cell Line; Cell Survival; Curcumin; Diabetes Mellitus, Exper | 2020 |
Combined effects of metformin and photobiomodulation improve the proliferation phase of wound healing in type 2 diabetic rats.
Topics: Animals; Blood Glucose; Cell Proliferation; Combined Modality Therapy; Diabetes Mellitus, Experiment | 2020 |
Fabrication of separable microneedles with phase change coating for NIR-triggered transdermal delivery of metformin on diabetic rats.
Topics: Administration, Cutaneous; Animals; Coated Materials, Biocompatible; Diabetes Mellitus, Experimental | 2020 |
HWL-088, a new potent free fatty acid receptor 1 (FFAR1) agonist, improves glucolipid metabolism and acts additively with metformin in ob/ob diabetic mice.
Topics: Animals; Diabetes Mellitus, Experimental; Fatty Acids, Nonesterified; Insulin; Insulin Secretion; Me | 2020 |
Can gallic acid potentiate the antihyperglycemic effect of acarbose and metformin? Evidence from streptozotocin-induced diabetic rat model.
Topics: Acarbose; alpha-Amylases; alpha-Glucosidases; Animals; Antioxidants; Blood Glucose; Diabetes Mellitu | 2022 |
Metformin and trimetazidine ameliorate diabetes-induced cognitive impediment in status epileptic rats.
Topics: Administration, Oral; Animals; Cognitive Dysfunction; Diabetes Mellitus, Experimental; Hippocampus; | 2020 |
Effect of superparamagnetic iron oxide nanoparticles on glucose homeostasis on type 2 diabetes experimental model.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Ferric Compounds | 2020 |
Zingiber officinale preserves testicular structure and the expression of androgen receptors and proliferating cell nuclear antigen in diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Drug Therapy, Combination; Humans; Hypoglyc | 2020 |
Stereological study on the numerical plasticity of myelinated fibers and oligodendrocytes in the rat spinal cord with painful diabetic neuropathy.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Hypoglyc | 2020 |
Combination of metformin and berberine represses the apoptosis of sebocytes in high-fat diet-induced diabetic hamsters and an insulin-treated human cell line.
Topics: Animals; Apoptosis; Berberine; Cells, Cultured; Diabetes Mellitus, Experimental; Diet, High-Fat; Dru | 2020 |
Impact of Disturbed Glucose Homeostasis Regulated by AMPK in Endometrium on Embryo Implantation in Diabetes Mice.
Topics: Adenylate Kinase; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes, Gestational; Em | 2020 |
Co-administration of Selenium Nanoparticles and Metformin Abrogate Testicular Oxidative Injury by Suppressing Redox Imbalance, Augmenting Sperm Quality and Nrf2 Protein Expression in Streptozotocin-Induced Diabetic Rats.
Topics: Animals; Diabetes Mellitus, Experimental; Male; Metformin; Nanoparticles; NF-E2-Related Factor 2; Ox | 2020 |
Metformin Reduces the Senescence of Renal Tubular Epithelial Cells in Diabetic Nephropathy via the MBNL1/miR-130a-3p/STAT3 Pathway.
Topics: Animals; Cells, Cultured; Cellular Senescence; Diabetes Mellitus, Experimental; Diabetic Nephropathi | 2020 |
Comparative effects of glibenclamide, metformin and insulin on fetal pancreatic histology and maternal blood glucose in pregnant streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetes, Gestational; Female; | 2019 |
The protective effect of metformin on mitochondrial dysfunction and endoplasmic reticulum stress in diabetic mice brain.
Topics: Animals; Apoptosis; ATP-Dependent Proteases; Brain; Chaperonin 60; Diabetes Mellitus, Experimental; | 2020 |
Citrus fruit-derived flavonoid naringenin and the expression of hepatic organic cation transporter 1 protein in diabetic rats treated with metformin.
Topics: Animals; Blood Glucose; Citrus; Diabetes Mellitus, Experimental; Flavanones; Flavonoids; Hypoglycemi | 2020 |
Linum usitatissimum seed mucilage-alginate mucoadhesive microspheres of metformin HCl: Fabrication, characterization and evaluation.
Topics: Alginates; Alloxan; Animals; Diabetes Mellitus, Experimental; Drug Compounding; Drug Liberation; Fla | 2020 |
Effect of metformin on testicular expression and localization of leptin receptor and levels of leptin in the diabetic mice.
Topics: Animals; Cell Proliferation; Diabetes Mellitus, Experimental; Gene Expression; Leptin; Leydig Cells; | 2020 |
Hydroalcoholic extract of Achillea millefolium improved blood glucose, liver enzymes and lipid profile compared to metformin in streptozotocin-induced diabetic rats.
Topics: Achillea; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Lipids; Live | 2020 |
Glucose lowering and pancreato-protective effects of Abrus Precatorius (L.) leaf extract in normoglycemic and STZ/Nicotinamide - Induced diabetic rats.
Topics: Abrus; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Fe | 2020 |
NLRP3 inflammasome drives inflammation in high fructose fed diabetic rat liver: Effect of resveratrol and metformin.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Fructose; Hypoglycemic Agents; | 2020 |
Evaluation of hepatic CYP2D1 activity and hepatic clearance in type I and type II diabetic rat models, before and after treatment with insulin and metformin.
Topics: Animals; Cytochrome P450 Family 2; Dextromethorphan; Diabetes Mellitus, Experimental; Diabetes Melli | 2020 |
Histomorphological, VEGF and TGF-β immunoexpression changes in the diabetic rats' ovary and the potential amelioration following treatment with metformin and insulin.
Topics: Animals; Diabetes Mellitus, Experimental; Down-Regulation; Female; Hypoglycemic Agents; Immunohistoc | 2020 |
Metformin pretreatment suppresses alterations to the articular cartilage ultrastructure and knee joint tissue damage secondary to type 2 diabetes mellitus in rats.
Topics: Animals; Cartilage, Articular; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Hypoglyce | 2020 |
Design and development of polymethylmethacrylate-grafted gellan gum (PMMA-g-GG)-based pH-sensitive novel drug delivery system for antidiabetic therapy.
Topics: Administration, Oral; Animals; Diabetes Mellitus, Experimental; Drug Delivery Systems; Drug Design; | 2020 |
Positive interaction of mangiferin with selected oral hypoglycemic drugs: a therapeutic strategy to alleviate diabetic nephropathy in experimental rats.
Topics: Animals; Antioxidants; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetic Nephropathies; D | 2020 |
Restoration of β-Adrenergic Signaling and Activity of Akt-Kinase and AMP-Activated Protein Kinase with Metformin in the Myocardium of Diabetic Rats.
Topics: AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; | 2020 |
A specific gut microbiota and metabolomic profiles shifts related to antidiabetic action: The similar and complementary antidiabetic properties of type 3 resistant starch from Canna edulis and metformin.
Topics: Animals; Bacteria; Biomarkers; Blood Glucose; Chromatography, Liquid; Diabetes Mellitus, Experimenta | 2020 |
Untargeted metabolomics analysis on Cicer arietinium L.-Induced Amelioration in T2D rats by UPLC-Q-TOF-MS/MS.
Topics: Animals; Biomarkers; Blood Glucose; Chromatography, High Pressure Liquid; Cicer; Diabetes Mellitus, | 2020 |
Metformin and Berberine suppress glycogenolysis by inhibiting glycogen phosphorylase and stabilizing the molecular structure of glycogen in db/db mice.
Topics: Animals; Berberine; Diabetes Mellitus, Experimental; Drug Therapy, Combination; Glycogenolysis; Hypo | 2020 |
Neuromodulatory effects of green coffee bean extract against brain damage in male albino rats with experimentally induced diabetes.
Topics: Animals; Blood Glucose; Brain; Coffee; Diabetes Mellitus, Experimental; Dopamine; Hypoglycemic Agent | 2020 |
Metformin Corrects Abnormal Circadian Rhythm and Kir4.1 Channels in Diabetes.
Topics: Animals; Cells, Cultured; Circadian Rhythm; Diabetes Mellitus, Experimental; Diabetic Retinopathy; D | 2020 |
Metformin Preserves Peripheral Nerve Damage with Comparable Effects to Alpha Lipoic Acid in Streptozotocin/High-Fat Diet Induced Diabetic Rats.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Diet, High-Fat; Male; Metformin; Ra | 2020 |
Development and characterization of spheroidal antidiabetic polyherbal formulation from fresh vegetable juice: A novel approach.
Topics: Animals; Diabetes Mellitus, Experimental; Fruit and Vegetable Juices; Humans; Hypoglycemic Agents; M | 2021 |
Protective effects of Artemisia judaica extract compared to metformin against hepatorenal injury in high-fat diet/streptozotocine-induced diabetic rats.
Topics: Animals; Antioxidants; Artemisia; Blood Glucose; Diabetes Mellitus, Experimental; Diet, High-Fat; Li | 2020 |
Berberine Inhibits Gluconeogenesis in Skeletal Muscles and Adipose Tissues in Streptozotocin-induced Diabetic Rats via LKB1-AMPK-TORC2 Signaling Pathway.
Topics: Adipose Tissue; AMP-Activated Protein Kinases; Animals; Berberine; Diabetes Mellitus, Experimental; | 2020 |
Supercritical carbon dioxide extracts of small cardamom and yellow mustard seeds have fasting hypoglycaemic effects: diabetic rat, predictive iHOMA2 models and molecular docking study.
Topics: Animals; Carbon Dioxide; Chemical Fractionation; Diabetes Mellitus, Experimental; Elettaria; Gene Ex | 2021 |
Anti-diabetic effect of a novel oligosaccharide isolated from Rosa canina via modulation of DNA methylation in Streptozotocin-diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; DNA Methylation; DNA Modification Methylases; Epigenesis, | 2020 |
Polyherbal mixture ameliorates hyperglycemia, hyperlipidemia and histopathological changes of pancreas, kidney and liver in a rat model of type 1 diabetes.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Fe | 2021 |
Metformin protects against diabetes-induced heart injury and dunning prostate cancer model.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Antioxidants; Cell Line, Tumor; Diabetes M | 2021 |
Impact of hyperglycemia and treatment with metformin on ligature-induced bone loss, bone repair and expression of bone metabolism transcription factors.
Topics: Alveolar Bone Loss; Alveolar Process; Animals; Bone Regeneration; Cell Differentiation; Cytokines; D | 2020 |
Normalization of Testicular Steroidogenesis and Spermatogenesis in Male Rats with Type 2 Diabetes Mellitus under the Conditions of Metformin Therapy.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Hypoglycemic Ag | 2020 |
Dysfunction of CD8 + PD-1 + T cells in type 2 diabetes caused by the impairment of metabolism-immune axis.
Topics: Animals; CD8-Positive T-Lymphocytes; Diabetes Mellitus, Experimental; Diet, High-Fat; Female; Lympho | 2020 |
The effects of high-fat diet and metformin on urinary metabolites in diabetes and prediabetes rat models.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; | 2021 |
The effect of metformin treatment on the basal and gonadotropin-stimulated steroidogenesis in male rats with type 2 diabetes mellitus.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Humans; Male; Metformin; Rats; | 2020 |
The Protective Effects of L-Carnitine and Zinc Oxide Nanoparticles Against Diabetic Injury on Sex Steroid Hormones Levels, Oxidative Stress, and Ovarian Histopathological Changes in Rat.
Topics: Animals; Antioxidants; Biomarkers; Blood Glucose; Carnitine; Diabetes Mellitus, Experimental; Female | 2021 |
Protective effect of acorn (Quercus liaotungensis Koidz) on streptozotocin-damaged MIN6 cells and type 2 diabetic rats via p38 MAPK/Nrf2/HO-1 pathway.
Topics: Animals; Blood Glucose; Cell Line; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dose- | 2021 |
Disparate Effects of Metformin on Mycobacterium tuberculosis Infection in Diabetic and Nondiabetic Mice.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Hypoglycemic Agents; Metformin; | 2020 |
Metformin attenuated histopathological ocular deteriorations in a streptozotocin-induced hyperglycemic rat model.
Topics: Animals; Claudin-1; Diabetes Complications; Diabetes Mellitus, Experimental; Eye Diseases; Glutathio | 2021 |
Selenium nanoparticles and metformin ameliorate streptozotocin-instigated brain oxidative-inflammatory stress and neurobehavioral alterations in rats.
Topics: Acetylcholinesterase; Animals; Behavior, Animal; Brain; Caspase 3; Diabetes Mellitus, Experimental; | 2021 |
Repaglinide and Metformin-Loaded Amberlite Resin-Based Floating Microspheres for the Effective Management of Type 2 Diabetes.
Topics: Animals; Carbamates; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Metformin; Mice; Mi | 2021 |
Characterization and anti-diabetic nephropathic ability of mycelium polysaccharides from Coprinus comatus.
Topics: Animals; Antioxidants; Coprinus; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Hypoglycem | 2021 |
The Effects of Altered Endometrial Glucose Homeostasis on Embryo Implantation in Type 2 Diabetic Mice.
Topics: AMP-Activated Protein Kinases; Animals; Biomarkers; Blood Glucose; Diabetes Mellitus, Experimental; | 2021 |
Huangkui capsule in combination with metformin ameliorates diabetic nephropathy via the Klotho/TGF-β1/p38MAPK signaling pathway.
Topics: Animals; Cell Line; Cell Proliferation; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Die | 2021 |
Effect of Combined
Topics: Animals; Crassulaceae; Cytokines; Diabetes Mellitus, Experimental; Humans; Metformin; Muscle Fibers, | 2021 |
Effects of HuoxueJiangtang decoction alone or in combination with metformin on renal function and renal cortical mRNA expression in diabetic nephropathy rats.
Topics: Animals; Blood Glucose; Captopril; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Drug The | 2020 |
Protective effect of metformin on rat diabetic retinopathy involves suppression of toll-like receptor 4/nuclear factor-k B expression and glutamate excitotoxicity.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Glutamic Acid; Hypoglycemic Agents; | 2021 |
Autophagy blockade mechanistically links proton pump inhibitors to worsened diabetic nephropathy and aborts the renoprotection of metformin/enalapril.
Topics: Albuminuria; Animals; Autophagy; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Diet, High | 2021 |
SGLT2-i improves markers of islet endothelial cell function in db/db diabetic mice.
Topics: Animals; Benzhydryl Compounds; Blood Glucose; Diabetes Mellitus, Experimental; Drug Evaluation, Prec | 2021 |
The Anti-Diabetic Drug Metformin from the Neuropathy Perspective.
Topics: Animals; Diabetes Mellitus, Experimental; Diet, High-Fat; Metformin; Peripheral Nerves; Pharmaceutic | 2020 |
High Throughput Study for Molecular Mechanism of Metformin Pre-Diabetic Protection via Microarray Approach.
Topics: Animals; Chemoprevention; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Gene Expressio | 2022 |
Metformin ameliorates ROS-p53-collagen axis of fibrosis and dyslipidemia in type 2 diabetes mellitus-induced left ventricular injury.
Topics: Animals; Collagen; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dyslipidemias; Fibros | 2023 |
Metformin Preserves Peripheral Nerve Damage with Comparable Effects to Alpha Lipoic Acid in Streptozotocin/High-Fat Diet Induced Diabetic Rats (Diabetes Metab J 2020;44:842-53).
Topics: Animals; Diabetes Mellitus, Experimental; Diet, High-Fat; Metformin; Peripheral Nerves; Rats; Strept | 2021 |
Metformin Preserves Peripheral Nerve Damage with Comparable Effects to Alpha Lipoic Acid in Streptozotocin/High-Fat Diet Induced Diabetic Rats (Diabetes Metab J 2020;44:842-53).
Topics: Animals; Diabetes Mellitus, Experimental; Diet, High-Fat; Metformin; Peripheral Nerves; Rats; Strept | 2021 |
Metformin impairs homing ability and efficacy of mesenchymal stem cells for cardiac repair in streptozotocin-induced diabetic cardiomyopathy in rats.
Topics: AMP-Activated Protein Kinases; Animals; Blood Glucose; Cell Movement; Cell Survival; Cells, Cultured | 2021 |
Combination of bis (α-furancarboxylato) oxovanadium (IV) and metformin improves hepatic steatosis through down-regulating inflammatory pathways in high-fat diet-induced obese C57BL/6J mice.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diet, | 2021 |
The aberrant expression of CD69 on peripheral T-helper cells in diet-induced inflammation is ameliorated by low-dose aspirin and metformin treatment.
Topics: Animals; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Aspirin; Blood Glucose; Diabetes Mel | 2021 |
Exploration of SQC Formula Effect on Type 2 Diabetes Mellitus by Whole Transcriptome Profile in Rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Drugs, Chinese H | 2021 |
Berberine ameliorates neuronal AD-like change via activating Pi3k/PGCε pathway.
Topics: Amyloid beta-Peptides; Animals; Berberine; Cell Line, Tumor; Cognitive Dysfunction; Diabetes Mellitu | 2021 |
Comparative evaluation of metformin and liraglutide cardioprotective effect in rats with impaired glucose tolerance.
Topics: Animals; Biomarkers; Blood Glucose; Body Weight; Cardiotonic Agents; Diabetes Mellitus, Experimental | 2021 |
Microfluidic-based synthesized carboxymethyl chitosan nanoparticles containing metformin for diabetes therapy: In vitro and in vivo assessments.
Topics: Animals; Blood Glucose; Chitosan; Delayed-Action Preparations; Diabetes Mellitus, Experimental; Drug | 2021 |
Vanillin exerts therapeutic effects against hyperglycemia-altered glucose metabolism and purinergic activities in testicular tissues of diabetic rats.
Topics: Acetylcholinesterase; Animals; Antioxidants; Benzaldehydes; Blood Glucose; Diabetes Mellitus, Experi | 2021 |
Hepatoprotective Effects of Polydatin-Loaded Chitosan Nanoparticles in Diabetic Rats: Modulation of Glucose Metabolism, Oxidative Stress, and Inflammation Biomarkers.
Topics: Animals; Chitosan; Diabetes Mellitus, Experimental; Glucose; Glucosides; Inflammation; Lipid Peroxid | 2021 |
Antidiabetic potential of Andrographis echioides Nees. leaf extract on high fat diet-fed C57BL/6J diabetic mice.
Topics: Alanine Transaminase; Andrographis; Animals; Aspartate Aminotransferases; Biomarkers; Blood Glucose; | 2020 |
Antidiabetic effect of
Topics: Alanine Transaminase; Alkaline Phosphatase; Alkaloids; Animals; Aspartate Aminotransferases; Diabete | 2021 |
Brain Boron Level, DNA Content, and Myeloperoxidase Activity of Metformin-Treated Rats in Diabetes and Prostate Cancer Model.
Topics: Animals; Boron; Brain; Diabetes Mellitus, Experimental; Humans; Hypoglycemic Agents; Male; Metformin | 2022 |
Swietenine potentiates the antihyperglycemic and antioxidant activity of Metformin in Streptozotocin induced diabetic rats.
Topics: Animals; Antioxidants; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental; Dose-Response Re | 2021 |
Rutaecarpine enhances the anti-diabetic activity and hepatic distribution of metformin via up-regulation of Oct1 in diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Humans; Hypoglycemic Agents; Indole Alkaloids; Liver; Metf | 2021 |
DBPR108, a novel dipeptidyl peptidase-4 inhibitor with antihyperglycemic activity.
Topics: Administration, Oral; Animals; Area Under Curve; Body Weight; Butanes; Diabetes Mellitus, Experiment | 2021 |
Metformin protects against neuroinflammation through integrated mechanisms of miR-141 and the NF-ĸB-mediated inflammasome pathway in a diabetic mouse model.
Topics: Animals; Brain; Computational Biology; Diabetes Mellitus, Experimental; Inflammasomes; Inflammation; | 2021 |
Chickpea Extract Ameliorates Metabolic Syndrome Symptoms via Restoring Intestinal Ecology and Metabolic Profile in Type 2 Diabetic Rats.
Topics: Animals; Cicer; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Dysbiosi | 2021 |
The therapeutic role of lactobacillus and montelukast in combination with metformin in diabetes mellitus complications through modulation of gut microbiota and suppression of oxidative stress.
Topics: Acetates; Animals; Cyclopropanes; Cytochrome P-450 CYP1A2 Inducers; Diabetes Complications; Diabetes | 2021 |
Histological and biochemical investigation of the renoprotective effects of metformin in diabetic and prostate cancer model.
Topics: Animals; Antioxidants; Catalase; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Kidney; Lipid | 2021 |
Normalizing glucose levels reconfigures the mammary tumor immune and metabolic microenvironment and decreases metastatic seeding.
Topics: Adult; Aged; Aged, 80 and over; Animals; Breast Neoplasms; Diabetes Mellitus, Experimental; Female; | 2021 |
The Effect of Metformin in Diabetic and Non-Diabetic Rats with Experimentally-Induced Chronic Kidney Disease.
Topics: Adenine; Animals; Diabetes Mellitus, Experimental; Kidney; MAP Kinase Signaling System; Metformin; R | 2021 |
Diabetes induces macrophage dysfunction through cytoplasmic dsDNA/AIM2 associated pyroptosis.
Topics: Aging; Animals; Antigen Presentation; Chemotaxis; Cytokines; Cytoplasm; Diabetes Mellitus, Experimen | 2021 |
Comparative effects of metformin and Cistus laurifolius L. extract in streptozotocin-induced diabetic rat model: oxidative, inflammatory, apoptotic, and histopathological analyzes.
Topics: Animals; Blood Glucose; Cistus; Diabetes Mellitus, Experimental; Metformin; Oxidative Stress; Plant | 2021 |
Effects of Berberine on Diabetes and Cognitive Impairment in an Animal Model: The Mechanisms of Action.
Topics: Animals; Apoptosis; Berberine; Cognitive Dysfunction; Diabetes Mellitus, Experimental; Diet, High-Fa | 2021 |
Metformin in Combination with Malvidin Prevents Progression of Non-Alcoholic Fatty Liver Disease via Improving Lipid and Glucose Metabolisms, and Inhibiting Inflammation in Type 2 Diabetes Rats.
Topics: Animals; Anthocyanins; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Progressi | 2021 |
Effects of first-line diabetes therapy with biguanides, sulphonylurea and thiazolidinediones on the differentiation, proliferation and apoptosis of islet cell populations.
Topics: Animals; Apoptosis; Blood Glucose; Cell Differentiation; Cell Proliferation; Cell Transdifferentiati | 2022 |
Suppressor of cytokine signalling-2 controls hepatic gluconeogenesis and hyperglycemia by modulating JAK2/STAT5 signalling pathway.
Topics: Animals; Blood Glucose; Cell Line; Cell Line, Tumor; Cytokines; Diabetes Mellitus, Experimental; Dia | 2021 |
Malaysian Propolis and Metformin Synergistically Mitigate Kidney Oxidative Stress and Inflammation in Streptozotocin-Induced Diabetic Rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Creatinine; Diabetes Mellitus, Experimental; Diabet | 2021 |
Metformin Targets Foxo1 to Control Glucose Homeostasis.
Topics: Animals; Aspirin; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Female; | 2021 |
GC-MS metabolomics reveals dysregulated lipid metabolic pathways and metabolites in diabetic testicular toxicity: Therapeutic potentials of raffia palm (Raphia hookeri G. Mann & H. Wendl) wine.
Topics: Alcoholic Beverages; Animals; Columbiformes; Diabetes Mellitus, Experimental; Gas Chromatography-Mas | 2021 |
Hepatoprotective and hypolipidemic activities of Caesalpinia bonduc seed kernels and Gymnema sylvestre leaves extracts in alloxan-induced diabetic rats.
Topics: Animals; Blood Glucose; Caesalpinia; Diabetes Mellitus, Experimental; Gymnema sylvestre; Hypoglycemi | 2021 |
Metformin prevents p-tau and amyloid plaque deposition and memory impairment in diabetic mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitu | 2021 |
Metformin inhibits MAPK signaling and rescues pancreatic aquaporin 7 expression to induce insulin secretion in type 2 diabetes mellitus.
Topics: Animals; Aquaporins; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Di | 2021 |
Metformin attenuates vascular pathology by increasing expression of insulin-degrading enzyme in a mixed model of cerebral amyloid angiopathy and type 2 diabetes mellitus.
Topics: Amyloid beta-Peptides; Animals; Cerebral Amyloid Angiopathy; Cerebrovascular Circulation; Diabetes M | 2021 |
L-ergothioneine and its combination with metformin attenuates renal dysfunction in type-2 diabetic rat model by activating Nrf2 antioxidant pathway.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Nephropa | 2021 |
Metformin attenuates renal tubulointerstitial fibrosis via upgrading autophagy in the early stage of diabetic nephropathy.
Topics: Animals; Autophagy; Biomarkers; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Epithelial | 2021 |
The effects of metformin on fibroblast growth factor 19, 21 and fibroblast growth factor receptor 1 in high-fat diet and streptozotocin induced diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Diet, High-Fat; Fibroblast Growth Factors; Hypoglycemic Ag | 2017 |
Development of a Novel Zebrafish Model for Type 2 Diabetes Mellitus.
Topics: Animals; Animals, Genetically Modified; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mel | 2017 |
Metformin improves the glucose and lipid metabolism via influencing the level of serum total bile acids in rats with streptozotocin-induced type 2 diabetes mellitus.
Topics: Animals; Bile Acids and Salts; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucose; | 2017 |
Liver Kinase B1/AMP-Activated Protein Kinase Pathway Activation Attenuated the Progression of Endotoxemia in the Diabetic Mice.
Topics: AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Experimental; Disease Progression; Endoto | 2017 |
Pterostilbene ameliorates insulin sensitivity, glycemic control and oxidative stress in fructose-fed diabetic rats.
Topics: Animals; beta-Cyclodextrins; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type | 2017 |
New Biguanides as Anti-Diabetic Agents Part I: Synthesis and Evaluation of 1-Substituted Biguanide Derivatives as Anti-Diabetic Agents of Type II Diabetes Insulin Resistant.
Topics: Animals; Biguanides; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Hypoglycemic Agents | 2017 |
Antidiabetic, antioxidant and anti inflammatory properties of water and n-butanol soluble extracts from Saharian Anvillea radiata in high-fat-diet fed mice.
Topics: 1-Butanol; Animals; Anti-Inflammatory Agents; Antioxidants; Asteraceae; Cell Line; Cell Line, Tumor; | 2017 |
Immunosuppression with tacrolimus improved implantation and rescued expression of uterine progesterone receptor and its co-regulators FKBP52 and PIASy at nidation in the obese and diabetic mice: Comparative studies with metformin.
Topics: Animals; Diabetes Mellitus, Experimental; Diet, High-Fat; Embryo Implantation; Female; Granulocyte-M | 2018 |
Oxamate Enhances the Anti-Inflammatory and Insulin-Sensitizing Effects of Metformin in Diabetic Mice.
Topics: Animals; Anti-Inflammatory Agents; Blood Glucose; Cytokines; Diabetes Mellitus, Experimental; Diabet | 2017 |
Metformin attenuates the TLR4 inflammatory pathway in skeletal muscle of diabetic rats.
Topics: Animals; Chemokine CXCL1; Diabetes Mellitus, Experimental; Humans; Hypoglycemic Agents; Insulin Resi | 2017 |
Metformin and ascorbic acid combination therapy ameliorates type 2 diabetes mellitus and comorbid depression in rats.
Topics: Animals; Ascorbic Acid; Biogenic Monoamines; Blood Glucose; Comorbidity; Corticosterone; Cytokines; | 2017 |
Murraya paniculata (L.) (Orange Jasmine): Potential Nutraceuticals with Ameliorative Effect in Alloxan-Induced Diabetic Rats.
Topics: Alloxan; Animals; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental; Dietary Supplements; | 2017 |
Metformin protects against retinal cell death in diabetic mice.
Topics: Animals; Blood Glucose; Cell Death; Cells, Cultured; Diabetes Mellitus, Experimental; Humans; Hypogl | 2017 |
Scopoletin Supplementation Ameliorates Steatosis and Inflammation in Diabetic Mice.
Topics: Animals; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental; Diet, High-Fat; Dietary Supple | 2017 |
Restoration of plasma markers of liver and kidney functions/integrity in alloxan-induced diabetic rabbits by aqueous extract of Pleurotus tuberregium sclerotia.
Topics: Alloxan; Animals; Biomarkers; Blood Urea Nitrogen; Chromatography, Gas; Diabetes Mellitus, Experimen | 2017 |
Combination of Rheum ribes and Metformin Against Diabetes, Thermal Hyperalgesia, and Tactile Allodynia in a Mice Model.
Topics: Animals; Antioxidants; Biomarkers; Blood Glucose; Diabetes Mellitus, Experimental; Glyburide; Hypera | 2018 |
Metformin accelerates wound healing in type 2 diabetic db/db mice.
Topics: Animals; Biomarkers; Blood Glucose; Diabetes Complications; Diabetes Mellitus, Experimental; Diabete | 2017 |
New Biguanides as Anti-Diabetic Agents, Part II: Synthesis and Anti-Diabetic Properties Evaluation of 1-Arylamidebiguanide Derivatives as Agents of Insulin Resistant Type II Diabetes.
Topics: Administration, Oral; Animals; Biguanides; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type | 2017 |
Changes in CYP2D enzyme activity following induction of type 2 diabetes, and administration of cinnamon and metformin: an experimental animal study.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cinnamomum zeylanicum; Cytochrome P450 F | 2018 |
[Study on effect of Jiangtang decoction on AGEs-RAGE and oxidative stress in KK-Ay mice].
Topics: Animals; Catalase; Diabetes Mellitus, Experimental; Drugs, Chinese Herbal; Glycation End Products, A | 2017 |
Effect of human umbilical cord blood-derived mononuclear cells on diabetic nephropathy in rats.
Topics: Animals; Blood Glucose; Creatinine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Fetal B | 2018 |
Preliminary phytochemical screening, antioxidant and antihyperglycaemic activity of Moringa oleifera leaf extracts.
Topics: Alloxan; Animals; Antioxidants; Ascorbic Acid; Biphenyl Compounds; Blood Glucose; Diabetes Mellitus, | 2017 |
Synergistic actions of vitamin D and metformin on skeletal muscles and insulin resistance of type 2 diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Drug Synergism; | 2018 |
Anti-diabetic potential of Sapium ellipticum (Hochst) Pax leaf extract in Streptozotocin(STZ)-induced diabetic Wistar rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Liver; Male; Metformin | 2017 |
The effects of addition of coenzyme Q10 to metformin on sirolimus-induced diabetes mellitus.
Topics: Animals; Apoptosis; Diabetes Mellitus, Experimental; Drug Evaluation, Preclinical; Hypoglycemic Agen | 2019 |
Chrysin Induces Antidiabetic, Antidyslipidemic and Anti-Inflammatory Effects in Athymic Nude Diabetic Mice.
Topics: Animals; Anti-Inflammatory Agents; Blood Glucose; Cytokines; Diabetes Mellitus, Experimental; Flavon | 2017 |
Stachyose Improves Inflammation through Modulating Gut Microbiota of High-Fat Diet/Streptozotocin-Induced Type 2 Diabetes in Rats.
Topics: Animals; Diabetes Mellitus, Experimental; Diet, High-Fat; Gastrointestinal Microbiome; Inflammation; | 2018 |
Assessment of Pharmacological Responses to an Anti-diabetic Drug in a New Obese Type 2 Diabetic Rat Model.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, | 2017 |
Linalyl acetate restores endothelial dysfunction and hemodynamic alterations in diabetic rats exposed to chronic immobilization stress.
Topics: Animals; Blood Glucose; Blood Pressure; Diabetes Mellitus, Experimental; Endothelium, Vascular; Hear | 2018 |
Evaluation of the neonatal streptozotocin model of diabetes in rats: Evidence for a model of neuropathic pain.
Topics: Activating Transcription Factor 3; Amines; Animals; Animals, Newborn; Astrocytes; Cyclohexanecarboxy | 2018 |
Houttuynia cordata extract increased systemic exposure and liver concentrations of metformin through OCTs and MATEs in rats.
Topics: Animals; Antiporters; Diabetes Mellitus, Experimental; Drugs, Chinese Herbal; Houttuynia; Humans; Hy | 2018 |
AMPKα inactivation destabilizes atherosclerotic plaque in streptozotocin-induced diabetic mice through AP-2α/miRNA-124 axis.
Topics: AMP-Activated Protein Kinases; Animals; Collagen Type I; Collagen Type II; Diabetes Mellitus, Experi | 2018 |
Herb-drug interaction of Nisha Amalaki and Curcuminoids with metformin in normal and diabetic condition: A disease system approach.
Topics: Animals; Curcuma; Diabetes Mellitus, Experimental; Drug Therapy, Combination; Herb-Drug Interactions | 2018 |
Metformin impacts cecal bile acid profiles in mice.
Topics: Animals; Bile Acids and Salts; Cecum; Chromatography, High Pressure Liquid; Diabetes Mellitus, Exper | 2018 |
Resveratrol regulates hyperglycemia-induced modulations in experimental diabetic animal model.
Topics: Animals; Antioxidants; Blood Glucose; Calcium; Diabetes Mellitus, Experimental; Diabetes Mellitus, T | 2018 |
The role of organic cation transporter 2 inhibitor cimetidine, experimental diabetes mellitus and metformin on gabapentin pharmacokinetics in rats.
Topics: Amines; Animals; Cimetidine; Cyclohexanecarboxylic Acids; Diabetes Mellitus, Experimental; Gabapenti | 2018 |
Combined intervention of swimming plus metformin ameliorates the insulin resistance and impaired lipid metabolism in murine gestational diabetes mellitus.
Topics: Animals; Blood Glucose; Combined Modality Therapy; Diabetes Mellitus, Experimental; Diabetes, Gestat | 2018 |
Prebiotic Mannan-Oligosaccharides Augment the Hypoglycemic Effects of Metformin in Correlation with Modulating Gut Microbiota.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Drug Therapy, C | 2018 |
Synergistic and non-synergistic effects of salmon calcitonin and omega - 3 fatty acids on antioxidant, anti-inflammatory, and haematological indices in diabetic rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Calcitonin; Diabetes Mellitus, Experimental; Dose-R | 2018 |
Antioxidant, anti-inflammatory, and anti-apoptotic effects of zinc supplementation in testes of rats with experimentally induced diabetes.
Topics: Animals; Apoptosis; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dieta | 2018 |
Metabolomic analysis and biochemical changes in the urine and serum of streptozotocin-induced normal- and obese-diabetic rats.
Topics: Amino Acids; Animals; Blood Glucose; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Experime | 2018 |
Teucrium polium improves endothelial dysfunction by regulating eNOS and VCAM-1 genes expression and vasoreactivity in diabetic rat aorta.
Topics: Acetylcholine; Animals; Aorta; Blood Glucose; Diabetes Mellitus, Experimental; Endothelium, Vascular | 2018 |
The possible antidiabetic effects of vitamin D receptors agonist in rat model of type 2 diabetes.
Topics: Animals; Calcifediol; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Gene Expression Re | 2019 |
Facile synthesis and characterization of tailor-made pectin-gellan gum-bionanofiller composites as intragastric drug delivery shuttles.
Topics: Animals; Diabetes Mellitus, Experimental; Drug Delivery Systems; Drug Liberation; Ethanolamines; Hum | 2018 |
Neuroprotective effect of glucagon-like peptide-1 receptor agonist is independent of glycaemia normalization in type two diabetic rats.
Topics: Animals; Blood Glucose; Brain; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucagon- | 2018 |
Antioxidant, anti-inflammatory and synergistic anti-hyperglycemic effects of Malaysian propolis and metformin in streptozotocin-induced diabetic rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Blood Glucose; Caspase 3; Diabetes Mellitus, Experi | 2018 |
Metformin, sitagliptin, and liraglutide modulate serum retinol-binding protein-4 level and adipocytokine production in type 2 diabetes mellitus rat model.
Topics: Adipokines; Animals; Blood Glucose; Body Mass Index; Diabetes Mellitus, Experimental; Diabetes Melli | 2018 |
The effects of safranal, a constitute of saffron, and metformin on spatial learning and memory impairments in type-1 diabetic rats: behavioral and hippocampal histopathological and biochemical evaluations.
Topics: Animals; Behavior, Animal; Caspase 3; Cell Count; Crocus; Cyclohexenes; Diabetes Mellitus, Experimen | 2018 |
Sitagliptin attenuates myocardial apoptosis via activating LKB-1/AMPK/Akt pathway and suppressing the activity of GSK-3β and p38α/MAPK in a rat model of diabetic cardiomyopathy.
Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Animals; Apoptosis; Biomarkers; | 2018 |
The protective effect of formononetin on cognitive impairment in streptozotocin (STZ)-induced diabetic mice.
Topics: Animals; Behavior, Animal; Blood Glucose; Cell Line, Tumor; Cognition; Cognition Disorders; Diabetes | 2018 |
Probucol prevents blood-brain barrier dysfunction and cognitive decline in mice maintained on pro-diabetic diet.
Topics: Animals; Anti-Inflammatory Agents; Behavior, Animal; Blood-Brain Barrier; Cerebral Cortex; Cognition | 2019 |
Metformin Regulates the Expression of SK2 and SK3 in the Atria of Rats With Type 2 Diabetes Mellitus Through the NOX4/p38MAPK Signaling Pathway.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Gene | 2018 |
Malaysian propolis, metformin and their combination, exert hepatoprotective effect in streptozotocin-induced diabetic rats.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Diabetes Mellitus, Experimental; Drug Comb | 2018 |
Improving hepatic mitochondrial biogenesis as a postulated mechanism for the antidiabetic effect of Spirulina platensis in comparison with metformin.
Topics: Adiponectin; Animals; Biomarkers; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, | 2019 |
Metformin attenuates diabetes-induced tau hyperphosphorylation in vitro and in vivo by enhancing autophagic clearance.
Topics: Animals; Autophagy; Cell Line; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Hy | 2019 |
Antidiabetic Activity of Afobazole in Wistar Rats.
Topics: Animals; Anti-Anxiety Agents; Benzimidazoles; Blood Glucose; Body Weight; Diabetes Mellitus, Experim | 2018 |
Metformin attenuates increase of synaptic number in the rat spinal dorsal horn with painful diabetic neuropathy induced by type 2 diabetes: a stereological study.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Hypoglycemic Agents; Male; Metformi | 2018 |
Metformin increases glucose uptake and acts renoprotectively by reducing SHIP2 activity.
Topics: Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Gene Expressio | 2019 |
Metformin attenuates renal medullary hypoxia in diabetic nephropathy through inhibition uncoupling protein-2.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Hypoglycemic Agents; Hypoxia; Kidn | 2019 |
Apelin‑13 ameliorates metabolic and cardiovascular disorders in a rat model of type 2 diabetes with a high‑fat diet.
Topics: Animals; Atorvastatin; Biomarkers; Blood Glucose; Cardiovascular Diseases; Diabetes Mellitus, Experi | 2018 |
Metformin induces apoptosis in mesenchymal stromal cells and dampens their therapeutic efficacy in infarcted myocardium.
Topics: Adenylate Kinase; Animals; Apoptosis; Cardiotonic Agents; Diabetes Mellitus, Experimental; Female; H | 2018 |
Metformin alleviates hyperglycemia-induced apoptosis and differentiation suppression in osteoblasts through inhibiting the TLR4 signaling pathway.
Topics: Animals; Apoptosis; Bone Density; Bone Morphogenetic Protein 2; Cell Differentiation; Cell Line; Dia | 2019 |
Eugenol ameliorates insulin resistance, oxidative stress and inflammation in high fat-diet/streptozotocin-induced diabetic rat.
Topics: AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; | 2019 |
Ameliorative effects of protodioscin on experimental diabetic nephropathy.
Topics: Albuminuria; Animals; Blood Glucose; Blood Urea Nitrogen; Carboxymethylcellulose Sodium; Cholesterol | 2018 |
Down-regulation of steroidogenesis-related genes and its accompanying fertility decline in streptozotocin-induced diabetic male rats: ameliorative effect of metformin.
Topics: Animals; Cell Survival; Cholesterol Side-Chain Cleavage Enzyme; Diabetes Mellitus, Experimental; DNA | 2019 |
Combined synergetic potential of metformin loaded pectin-chitosan biohybrids nanoparticle for NIDDM.
Topics: Animals; Cell Line; Chemical Phenomena; Chitosan; Diabetes Mellitus, Experimental; Drug Carriers; Dr | 2019 |
Metformin hydrochloride and wound healing: from nanoformulation to pharmacological evaluation.
Topics: Administration, Cutaneous; Animals; Blood Glucose; Cholesterol; Delayed-Action Preparations; Diabete | 2019 |
Metformin regulates atrial SK2 and SK3 expression through inhibiting the PKC/ERK signaling pathway in type 2 diabetic rats.
Topics: Animals; Atrial Fibrillation; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Extracellu | 2018 |
Curcumin augments the cardioprotective effect of metformin in an experimental model of type I diabetes mellitus; Impact of Nrf2/HO-1 and JAK/STAT pathways.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cardiotonic Agents; Curcumin; Diabetes Mellitus, E | 2019 |
An HPLC method for the determination of adenosine diphosphate: An important marker of hexokinase activity in metabolic diseases.
Topics: Adenosine Diphosphate; Animals; Biomarkers; Chromatography, High Pressure Liquid; Diabetes Mellitus, | 2019 |
Comparative Biochemical and Histopathological Studies on the Efficacy of Metformin and Virgin Olive Oil against Streptozotocin-Induced Diabetes in Sprague-Dawley Rats.
Topics: Animals; Antioxidants; Blood Glucose; Combined Modality Therapy; Diabetes Mellitus, Experimental; Hy | 2018 |
Metformin alleviates hyperglycemia-induced endothelial impairment by downregulating autophagy via the Hedgehog pathway.
Topics: Animals; Autophagy; Capillary Permeability; Cells, Cultured; Diabetes Mellitus, Experimental; Diabet | 2019 |
Metformin as an add-on to insulin improves periodontal response during orthodontic tooth movement in type 1 diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Insulin; Metformin; Osteoclasts; Periodontal Ligament; Rat | 2019 |
Hypoglycemic and Hypolipidemic Effects of
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Hyperlipidemias; Hypoglycemic A | 2019 |
Imaging the Proangiogenic Effects of Cardiovascular Drugs in a Diabetic Model of Limb Ischemia.
Topics: Animals; Cardiovascular Agents; Diabetes Mellitus, Experimental; Hindlimb; Immunohistochemistry; Isc | 2019 |
Multi-target antidiabetic mechanisms of mexicanolides from Swietenia humilis.
Topics: Animals; Cell Line; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drug Synergis | 2019 |
Comparison of the Neuroprotective Effects of Aspirin, Atorvastatin, Captopril and Metformin in Diabetes Mellitus.
Topics: Animals; Aspirin; Atorvastatin; Captopril; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Mal | 2019 |
Metformin ameliorates experimental diabetic periodontitis independently of mammalian target of rapamycin (mTOR) inhibition by reducing NIMA-related kinase 7 (Nek7) expression.
Topics: Animals; Diabetes Mellitus, Experimental; Interleukin-1beta; Metformin; Mice; NIMA-Related Kinases; | 2019 |
In vivo pharmacodynamic and pharmacokinetic effects of metformin mediated by the gut microbiota in rats.
Topics: Administration, Oral; Animals; Blood Glucose; Catecholamine Plasma Membrane Transport Proteins; Chin | 2019 |
Antidiabetic effect of mangiferin in combination with oral hypoglycemic agents metformin and gliclazide.
Topics: Administration, Oral; Animals; Diabetes Mellitus, Experimental; Drug Therapy, Combination; Enzymes; | 2019 |
Metformin mitigates impaired testicular lactate transport/utilisation and improves sexual behaviour in streptozotocin-induced diabetic rats.
Topics: Animals; Biological Transport; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Glucose T | 2021 |
Asarone and metformin delays experimentally induced hepatocellular carcinoma in diabetic milieu.
Topics: Allylbenzene Derivatives; Animals; Anisoles; Carcinoma, Hepatocellular; Diabetes Mellitus, Experimen | 2019 |
The combination of exercise training and sodium-glucose cotransporter-2 inhibition improves glucose tolerance and exercise capacity in a rodent model of type 2 diabetes.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dis | 2019 |
Selected elements of extracellular matrix of the skin in diabetes and insulin resistance.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Extracellular Matrix; Insulin; Insulin Resis | 2019 |
Preventive role of metformin on peripheral neuropathy induced by diabetes.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Hyperglycemia; Hypog | 2019 |
Evaluation of Kidney Function Parameters in Diabetic Rats Following Virgin Coconut Oil Diet.
Topics: Animals; Blood Urea Nitrogen; Body Weight; Coconut Oil; Creatinine; Diabetes Mellitus, Experimental; | 2019 |
MODERN ASPECTS OF SUGAR-REDUCING EFFECT OF THICK BEAN EXTRACT BASED ON A TYPE II DIABETES MODEL ON THE BACKGROUND OF OBESITY.
Topics: Animals; Cell Size; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Hypoglycemic Agents; | 2019 |
Inhibition of neointima hyperplasia by the combined therapy of linagliptin and metformin via AMPK/Nox4 signaling in diabetic rats.
Topics: AMP-Activated Protein Kinases; Animals; Aorta, Thoracic; Carotid Arteries; Constriction, Pathologic; | 2019 |
Anti-diabetic effect of Murraya koenigii (L) and Olea europaea (L) leaf extracts on streptozotocin induced diabetic rats.
Topics: Administration, Oral; Animals; Biomarkers; Blood Glucose; Body Weight; Cholesterol; Creatinine; Diab | 2013 |
Synergistic interaction of ferulic acid with commercial hypoglycemic drugs in streptozotocin induced diabetic rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Blood Glucose; Coumaric Acids; Creatinin | 2013 |
Oral hypoglycemic activity of culinary-medicinal mushrooms Pleurotus ostreatus and P. cystidiosus (higher basidiomycetes) in normal and alloxan-induced diabetic Wistar rats.
Topics: Animal Feed; Animals; Diabetes Mellitus, Experimental; Dietary Supplements; Dose-Response Relationsh | 2012 |
Maintenance of endothelial guanosine triphosphate cyclohydrolase I ameliorates diabetic nephropathy.
Topics: Albuminuria; Animals; Biopterins; Cell Line; Diabetes Mellitus, Experimental; Diabetic Nephropathies | 2013 |
Formulation optimization and evaluation of jackfruit seed starch-alginate mucoadhesive beads of metformin HCl.
Topics: Alginates; Alloxan; Animals; Artocarpus; Calcium Chloride; Delayed-Action Preparations; Diabetes Mel | 2013 |
Hypoglycemic and anti-hyperglycemic study of Gynura procumbens leaf extracts.
Topics: Animals; Asteraceae; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Flavonoids; Glucos | 2013 |
Calcium pectinate-fenugreek seed mucilage mucoadhesive beads for controlled delivery of metformin HCl.
Topics: Adhesives; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Drug Delivery Systems; Female; G | 2013 |
Insulin-deficient diabetes-induced bone microarchitecture alterations are associated with a decrease in the osteogenic potential of bone marrow progenitor cells: preventive effects of metformin.
Topics: Animals; Bone Marrow Cells; Diabetes Mellitus, Experimental; Insulin; Male; Metformin; Osteogenesis; | 2013 |
Effect of the combination of metformin and fenofibrate on glucose homeostasis in diabetic Goto-Kakizaki rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Drug Therapy, Combination; Exe | 2013 |
Insulin restores myocardial presynaptic sympathetic neuronal integrity in insulin-resistant diabetic rats.
Topics: Animals; Contrast Media; Diabetes Mellitus, Experimental; Echocardiography; Ephedrine; Glucose Clamp | 2013 |
The combined effect of metformin and L-cysteine on inflammation, oxidative stress and insulin resistance in streptozotocin-induced type 2 diabetes in rats.
Topics: Animals; Body Weight; C-Reactive Protein; Caspase 3; Chemokine CCL2; Cysteine; Cytochromes c; Diabet | 2013 |
C-peptide activates AMPKα and prevents ROS-mediated mitochondrial fission and endothelial apoptosis in diabetes.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Apoptosis; C-Peptide; Cells, Cul | 2013 |
Lack of metformin effect on mouse embryo AMPK activity: implications for metformin treatment during pregnancy.
Topics: AMP-Activated Protein Kinases; Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetes, | 2014 |
Blends of jackfruit seed starch-pectin in the development of mucoadhesive beads containing metformin HCl.
Topics: Adhesiveness; Animals; Artocarpus; Diabetes Mellitus, Experimental; Drug Carriers; Drug Liberation; | 2013 |
Effect of kolaviron, a biflavonoid complex from Garcinia kola seeds, on the antioxidant, hormonal and spermatogenic indices of diabetic male rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Drug Evaluation, Preclinical; | 2014 |
Angiotensin II receptor blocker telmisartan prevents new-onset diabetes in pre-diabetes OLETF rats on a high-fat diet: evidence of anti-diabetes action.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Benzoates; Blood Glucose; Blood Pr | 2013 |
Potential utility of sodium selenate as an adjunct to metformin in treating type II diabetes mellitus in rats: a perspective on protein tyrosine phosphatase.
Topics: Adiponectin; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dru | 2013 |
Combining metformin and aerobic exercise training in the treatment of type 2 diabetes and NAFLD in OLETF rats.
Topics: Animals; Combined Modality Therapy; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Fatt | 2014 |
AMPK activation through mitochondrial regulation results in increased substrate oxidation and improved metabolic parameters in models of diabetes.
Topics: Amino Acids, Branched-Chain; AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Experimental | 2013 |
Endothelial cellular senescence is inhibited by liver X receptor activation with an additional mechanism for its atheroprotection in diabetes.
Topics: Administration, Oral; Animals; Aorta; Atherosclerosis; Cellular Senescence; Densitometry; Diabetes C | 2014 |
Characterization of the exocrine pancreas in the male Zucker diabetic fatty rat model of type 2 diabetes mellitus following 3 months of treatment with sitagliptin.
Topics: Administration, Oral; Animals; Blood Glucose; Body Weight; Cell Proliferation; Diabetes Mellitus, Ex | 2014 |
Late dual endothelin receptor blockade with bosentan restores impaired cerebrovascular function in diabetes.
Topics: Animals; Bosentan; Cerebrovascular Circulation; Diabetes Mellitus, Experimental; Endothelin B Recept | 2014 |
KDT501, a derivative from hops, normalizes glucose metabolism and body weight in rodent models of diabetes.
Topics: Adipocytes; Animals; Blood Glucose; Body Weight; Cells, Cultured; Diabetes Mellitus, Experimental; D | 2014 |
Tamarind seed polysaccharide-gellan mucoadhesive beads for controlled release of metformin HCl.
Topics: Administration, Oral; Alloxan; Animals; Diabetes Mellitus, Experimental; Drug Carriers; Hypoglycemic | 2014 |
Development of pectinate-ispagula mucilage mucoadhesive beads of metformin HCl by central composite design.
Topics: Adhesives; Administration, Oral; Animals; Blood Glucose; Delayed-Action Preparations; Diabetes Melli | 2014 |
Trigonella foenum-graecum L. seed mucilage-gellan mucoadhesive beads for controlled release of metformin HCl.
Topics: Adhesiveness; Animals; Capsules; Delayed-Action Preparations; Diabetes Mellitus, Experimental; Drug | 2014 |
Ispaghula mucilage-gellan mucoadhesive beads of metformin HCl: development by response surface methodology.
Topics: Adhesiveness; Animals; Computer-Aided Design; Diabetes Mellitus, Experimental; Drug Carriers; Female | 2014 |
Gliquidone versus metformin: differential effects on aorta in streptozotocin induced diabetic rats.
Topics: Animals; Aorta; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Hypoglycemic Agents; Male; M | 2014 |
Daily exercise training protects against albuminuria and angiotensin converting enzyme 2 shedding in db/db diabetic mice.
Topics: Albuminuria; Angiotensin-Converting Enzyme 2; Animals; Combined Modality Therapy; Diabetes Complicat | 2014 |
Aqueous extract of unfermented honeybush (Cyclopia maculata) attenuates STZ-induced diabetes and β-cell cytotoxicity.
Topics: Animals; Antioxidants; Blood Glucose; Cell Survival; Cyclopia Plant; Diabetes Mellitus, Experimental | 2014 |
Metformin impairs mitochondrial function in skeletal muscle of both lean and diabetic rats in a dose-dependent manner.
Topics: Animals; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Humans; Insulin; M | 2014 |
A comparative study on effect of metformin and metformin-conjugated nanotubes on blood glucose homeostasis in diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Homeostasis; Hypoglycemic Agents; Male; Met | 2015 |
Role of metformin in suppressing 1,2-dimethylhydrazine-induced colon cancer in diabetic and non-diabetic mice: effect on tumor angiogenesis and cell proliferation.
Topics: 1,2-Dimethylhydrazine; Animals; Antigens, CD34; Antineoplastic Agents; Cell Proliferation; Colon; Co | 2014 |
Diazepam potentiates the antidiabetic, antistress and anxiolytic activities of metformin in type-2 diabetes mellitus with cooccurring stress in experimental animals.
Topics: Animals; Anti-Anxiety Agents; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diazepam; | 2014 |
Effect of metformin on metabolic improvement and gut microbiota.
Topics: Animals; Biomarkers; Blood Glucose; Body Weight; Clostridium; Diabetes Mellitus, Experimental; Diabe | 2014 |
Metformin supports the antidiabetic effect of a sodium glucose cotransporter 2 inhibitor by suppressing endogenous glucose production in diabetic mice.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Drug Th | 2015 |
Metformin Restores Intermediate-Conductance Calcium-Activated K⁺ Channel- and Small-Conductance Calcium-Activated K⁺ Channel-Mediated Vasodilatation Impaired by Advanced Glycation End Products in Rat Mesenteric Artery. [Corrected].
Topics: AMP-Activated Protein Kinases; Animals; Cell Line; Diabetes Mellitus, Experimental; Down-Regulation; | 2014 |
Selective therapeutic effect of cornus officinalis fruits on the damage of different organs in STZ-induced diabetic rats.
Topics: Actins; Animals; Cornus; Diabetes Mellitus, Experimental; Fibrosis; Fruit; Hypoglycemic Agents; Insu | 2014 |
[Meilian Xiaoke capsule combined with metformin for protecting islet cells and lowering blood glucose in diabetic rats].
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Drug Synergism; | 2014 |
Phosphatase and tension homolog overexpression in insulin resistant diabetic adipose tissue.
Topics: Adipose Tissue; Animals; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Insulin Resistance; M | 2014 |
Protective effects of grape seed extract fractions with different degrees of polymerisation on blood glucose, lipids and hepatic oxidative stress in diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Grape Seed Extract; Lipids; Li | 2015 |
Diabetes and hyperlipidemia induce dysfunction of VSMCs: contribution of the metabolic inflammation/miRNA pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cells, Cultured; Connexins; Diabetes Mellitu | 2015 |
Evaluation of hypoglycemic efficacy of tangningtongluo formula, a traditional Chinese Miao medicine, in two rodent animal models.
Topics: Animals; Biomarkers; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Diabeti | 2014 |
Augmentation of diabetic wound healing and enhancement of collagen content using nanofibrous glucophage-loaded collagen/PLGA scaffold membranes.
Topics: Animals; Collagen; Diabetes Mellitus, Experimental; Drug Administration Routes; Hypoglycemic Agents; | 2015 |
Protective effect of metformin against walker 256 tumor growth is not dependent on metabolism improvement.
Topics: Animals; Blood Glucose; Carcinoma 256, Walker; Cell Proliferation; Diabetes Mellitus, Experimental; | 2014 |
[Metformin ameliorates β-cell dysfunction by regulating inflammation production, ion and hormone homeostasis of pancreas in diabetic KKAy mice].
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Down-Regulation; Female; Glucose Tolerance | 2014 |
Characterisation of pain responses in the high fat diet/streptozotocin model of diabetes and the analgesic effects of antidiabetic treatments.
Topics: Animal Feed; Animals; Behavior, Animal; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Neu | 2015 |
Combination therapy with oleanolic acid and metformin as a synergistic treatment for diabetes.
Topics: Animals; Biomarkers; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diseas | 2015 |
Taurine can enhance the protective actions of metformin against diabetes-induced alterations adversely affecting renal function.
Topics: Animals; Blood Glucose; Cytoprotection; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Dru | 2015 |
Evaluation of the actions of metformin and taurine, singly and in combination, on metabolic and oxidative alterations caused by diabetes in rat erythrocytes and plasma.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Erythrocytes; Glycated Hemoglobin; Insulin; | 2015 |
Ameliorative Effect of Adjunct Therapy of Metformin with Atorvastatin on Streptozotocin-induced Diabetes Mellitus in Rats.
Topics: Animals; Antioxidants; Atorvastatin; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellit | 2016 |
Metformin suppresses diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-+Leprdb/+Leprdb mice.
Topics: Adipokines; Animals; Animals, Newborn; Carcinogenesis; Diabetes Mellitus, Experimental; Diethylnitro | 2015 |
Vitamin D₃ prevents the increase in ectonucleotidase activities and ameliorates lipid profile in type 1 diabetic rats.
Topics: 5'-Nucleotidase; Adenosine Deaminase; Adenosine Triphosphatases; Animals; Blood Platelets; Cholecalc | 2015 |
Tetrapleura tetraptera spice attenuates high-carbohydrate, high-fat diet-induced obese and type 2 diabetic rats with metabolic syndrome features.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diet, High-Fat; Fruit; Hypoglycemic Agents; | 2015 |
Diabetic silkworms for evaluation of therapeutically effective drugs against type II diabetes.
Topics: Animals; Bombyx; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet; Drug Evaluation, | 2015 |
Metformin attenuates hyperalgesia and allodynia in rats with painful diabetic neuropathy induced by streptozotocin.
Topics: AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Enzy | 2015 |
Metformin Ameliorates Podocyte Damage by Restoring Renal Tissue Podocalyxin Expression in Type 2 Diabetic Rats.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Hypoglycemic Agents; Kidney; Ma | 2015 |
Methanolic extract of Moringa oleifera leaves improves glucose tolerance, glycogen synthesis and lipid metabolism in alloxan-induced diabetic rats.
Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; | 2015 |
Berberine inhibits hepatic gluconeogenesis via the LKB1-AMPK-TORC2 signaling pathway in streptozotocin-induced diabetic rats.
Topics: Active Transport, Cell Nucleus; Aminoimidazole Carboxamide; AMP-Activated Protein Kinase Kinases; AM | 2015 |
Effects of preventative application of metformin on bile acid metabolism in high fat-fed/streptozotocin-diabetic rats.
Topics: Animals; Bile Acids and Salts; Blood Glucose; Diabetes Mellitus, Experimental; Diet, High-Fat; Hypog | 2015 |
Metformin prevents DMH-induced colorectal cancer in diabetic rats by reversing the warburg effect.
Topics: Animals; Biomarkers; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Colorect | 2015 |
Combining metformin therapy with caloric restriction for the management of type 2 diabetes and nonalcoholic fatty liver disease in obese rats.
Topics: Animals; Blotting, Western; Caloric Restriction; Diabetes Mellitus, Experimental; Diabetes Mellitus, | 2015 |
A therapeutic TDS patch of Metformin from a HPMC-PVA blend studied with a biological membrane of fish-swim bladder: An approach for dermal application in NIDDM.
Topics: Administration, Cutaneous; Alloxan; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Typ | 2015 |
Electroacupuncture treatment of insulin resistance in diabetes mellitus.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Electroacupunctu | 2015 |
Metformin improves endothelial function in aortic tissue and microvascular endothelial cells subjected to diabetic hyperglycaemic conditions.
Topics: Adenylate Kinase; Animals; Aorta; Diabetes Mellitus, Experimental; Endothelium, Vascular; Gene Knock | 2015 |
A new Agkistrodon halys venom-purified protein C activator prevents myocardial fibrosis in diabetic rats.
Topics: Agkistrodon; Animals; Blood Glucose; Blotting, Western; Chromatography, Reverse-Phase; Collagen; Cro | 2015 |
Evaluation of the Association Metformin: Plantago ovata Husk in Diabetic Rabbits.
Topics: Administration, Oral; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dietary Fiber; Drug T | 2015 |
Metformin Protects Kidney Cells From Insulin-Mediated Genotoxicity In Vitro and in Male Zucker Diabetic Fatty Rats.
Topics: Animals; Antioxidants; Cells, Cultured; Cytoprotection; Diabetes Mellitus, Experimental; DNA Damage; | 2016 |
Metformin Improves Diabetic Bone Health by Re-Balancing Catabolism and Nitrogen Disposal.
Topics: Animals; Bone and Bones; Bone Density; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Male; M | 2015 |
Beneficial Effect of Metformin on Nerve Regeneration and Functional Recovery After Sciatic Nerve Crush Injury in Diabetic Rats.
Topics: Animals; Axons; Diabetes Mellitus, Experimental; Male; Metformin; Nerve Crush; Nerve Regeneration; N | 2016 |
[Protective effects of metformin on glomerular podocytes of type 2 diabetes model rats].
Topics: Animals; Blood Glucose; Creatinine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet | 2015 |
Comparative Study of the Antioxidant Effects of Metformin, Glibenclamide, and Repaglinide in Alloxan-Induced Diabetic Rats.
Topics: Alloxan; Animals; Antioxidants; Biomarkers; Blood Glucose; Carbamates; Catalase; Diabetes Complicati | 2016 |
Combretum lanceolatum flowers ethanol extract inhibits hepatic gluconeogenesis: an in vivo mechanism study.
Topics: AMP-Activated Protein Kinases; Animals; Biomarkers; Blood Glucose; Combretum; Diabetes Mellitus, Exp | 2016 |
Metformin Induces Cell Cycle Arrest, Reduced Proliferation, Wound Healing Impairment In Vivo and Is Associated to Clinical Outcomes in Diabetic Foot Ulcer Patients.
Topics: Adult; Aged; Animals; Cell Cycle Checkpoints; Cell Line; Diabetes Mellitus, Experimental; Diabetes M | 2016 |
A graphene-based electrochemical device with thermoresponsive microneedles for diabetes monitoring and therapy.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Drug Delivery Systems; Electrochemical Tech | 2016 |
Metformin stimulates IGFBP-2 gene expression through PPARalpha in diabetic states.
Topics: Adenylate Kinase; Aged; Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetes Mellitus | 2016 |
Liver MicroRNA-291b-3p Promotes Hepatic Lipogenesis through Negative Regulation of Adenosine 5'-Monophosphate (AMP)-activated Protein Kinase α1.
Topics: AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Experimental; Dietary Fats; Enzyme Activa | 2016 |
Effects of addition of a dipeptidyl peptidase IV inhibitor to metformin on sirolimus-induced diabetes mellitus.
Topics: Animals; Apoptosis; Cell Survival; Diabetes Mellitus, Experimental; Dipeptidyl-Peptidase IV Inhibito | 2016 |
Metforminium Decavanadate as a Potential Metallopharmaceutical Drug for the Treatment of Diabetes Mellitus.
Topics: Animals; Diabetes Mellitus, Experimental; Glucose Tolerance Test; Glycated Hemoglobin; Glycogen; Hyp | 2016 |
Saffron with resistance exercise improves diabetic parameters through the GLUT4/AMPK pathway in-vitro and in-vivo.
Topics: AMP-Activated Protein Kinases; Animals; Biological Transport; Blood Glucose; Cell Line; Crocus; Diab | 2016 |
The Effects of Pycnogenol® as Add-on Drug to Metformin Therapy in Diabetic Rats.
Topics: Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Flavonoids; Hypoglycemic Agents; M | 2016 |
Effects of metformin on inflammation and short-term memory in streptozotocin-induced diabetic mice.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Astrocytes; Blood Glucose; Diabetes Mellitus, Exp | 2016 |
Synthesis and Evaluation of 1-Substituted-Biguanide Derivatives as Anti-Diabetic Agents for Type II Diabetes Insulin Resistant.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biguanides; Blood Glucose; Cholesterol; | 2016 |
The functional activity of hypothalamic signaling systems in rats with neonatal diabetes mellitus treated with metformin.
Topics: Adenylyl Cyclases; Animals; Animals, Newborn; Animals, Outbred Strains; Diabetes Mellitus, Experimen | 2016 |
Lycium barbarum Polysaccharide Mediated the Antidiabetic and Antinephritic Effects in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats via Regulation of NF-κB.
Topics: Animals; Anti-Inflammatory Agents; Blood Glucose; Cytokines; Diabetes Mellitus, Experimental; Diabet | 2016 |
Effect of Vanadyl Rosiglitazone, a New Insulin-Mimetic Vanadium Complexes, on Glucose Homeostasis of Diabetic Mice.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Disease Models, Animal; Drinki | 2016 |
Metformin ameliorates podocyte damage by restoring renal tissue nephrin expression in type 2 diabetic rats.
Topics: Albuminuria; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Die | 2017 |
Sodium butyrate reduces insulin-resistance, fat accumulation and dyslipidemia in type-2 diabetic rat: A comparative study with metformin.
Topics: Acetylation; Adipose Tissue; Animals; Blood Glucose; Butyric Acid; Diabetes Mellitus, Experimental; | 2016 |
Metformin and resveratrol inhibit Drp1-mediated mitochondrial fission and prevent ER stress-associated NLRP3 inflammasome activation in the adipose tissue of diabetic mice.
Topics: 3T3-L1 Cells; Adipose Tissue; Animals; Apoptosis; Cell Differentiation; Diabetes Mellitus, Experimen | 2016 |
Metformin improves the angiogenic functions of endothelial progenitor cells via activating AMPK/eNOS pathway in diabetic mice.
Topics: AMP-Activated Protein Kinases; Animals; Cell Movement; Cells, Cultured; Diabetes Mellitus, Experimen | 2016 |
Combined therapy with metformin and insulin attenuates systemic and hepatic alterations in a model of high-fat diet-/streptozotocin-induced diabetes.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diet, High-Fat; Drug Synergism; Insulin; Li | 2016 |
[INFLUENCE OF MEDICINAL PLANT EXTRACTS ON THE FUNCTIONS AND ANTIOXIDANT PROTECTION OF ERYTHROCYTES IN RATS WITH EXPERIMENTAL DIABETES MELLITUS].
Topics: Animals; Animals, Outbred Strains; Arctium; Catalase; Diabetes Mellitus, Experimental; Diet, High-Fa | 2016 |
Effects of the Nrf2 Protein Modulator Salvianolic Acid A Alone or Combined with Metformin on Diabetes-associated Macrovascular and Renal Injury.
Topics: Alkenes; Animals; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diabetic Nephropathies; Gl | 2016 |
The influence of goutweed (Aegopodium podagraria L.) tincture and metformin on the carbohydrate and lipid metabolism in dexamethasone-treated rats.
Topics: Animals; Apiaceae; Blood Glucose; Dexamethasone; Diabetes Mellitus, Experimental; Glucose; Hypoglyce | 2016 |
The paraoxonase 1 (PON1), platelet-activating factor acetylohydrolase (PAF-AH) and dimethylarginine dimethylaminohydrolase (DDAH) activity in the metformin treated normal and diabetic rats.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Amidohydrolases; Animals; Aryldialkylphosphatase; Bo | 2016 |
Influence of Musa sapientum L. on pharmacokinetic of metformin in diabetic gastroparesis.
Topics: Alloxan; Animals; Blood Glucose; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experiment | 2016 |
Antidiabetic, antihyperlipidemic and anti-inflammatory effects of tilianin in streptozotocin-nicotinamide diabetic rats.
Topics: 3T3-L1 Cells; Adipose Tissue; Animals; Anti-Inflammatory Agents; Aorta; Blood Glucose; Diabetes Mell | 2016 |
Anti-inflammatory effect of AMPK signaling pathway in rat model of diabetic neuropathy.
Topics: AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dise | 2016 |
Geniposide reduces development of streptozotocin-induced diabetic nephropathy via regulating nuclear factor-kappa B signaling pathways.
Topics: Animals; Blotting, Western; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Dose-Response R | 2017 |
Effect of canagliflozin and metformin on cortical neurotransmitters in a diabetic rat model.
Topics: Acetylcholinesterase; Amino Acids; Animals; Biogenic Monoamines; Blood Glucose; Canagliflozin; Cereb | 2016 |
The Role of Metformin in Controlling Oxidative Stress in Muscle of Diabetic Rats.
Topics: Animals; Antioxidants; Catalase; Diabetes Mellitus, Experimental; Drug Therapy, Combination; Electro | 2016 |
Sirtuin 1 and 7 mediate resveratrol-induced recovery from hyper-anxiety in high-fructose-fed prediabetic rats.
Topics: Animals; Antioxidants; Anxiety Disorders; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes M | 2016 |
Piracetam Facilitates the Anti-Amnesic but not Anti-Diabetic Activity of Metformin in Experimentally Induced Type-2 Diabetic Encephalopathic Rats.
Topics: Amnesia; Animals; Blood Glucose; Brain Diseases; Brain-Derived Neurotrophic Factor; Choline; Diabete | 2017 |
Antidiabetic effects of Cuscuta reflexa Roxb. in streptozotocin induced diabetic rats.
Topics: Animals; Biomarkers; Blood Glucose; Body Weight; Cuscuta; Diabetes Mellitus, Experimental; Dose-Resp | 2016 |
Symplocos cochinchinensis enhances insulin sensitivity via the down regulation of lipogenesis and insulin resistance in high energy diet rat model.
Topics: Animals; Biomarkers; Blood Glucose; Diabetes Mellitus, Experimental; Diet, High-Fat; Dose-Response R | 2016 |
Effects of metformin on hyperglycemia in an experimental model of tacrolimus- and sirolimus-induced diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Humans; Hypoglycemic Agents; Immunosuppressive Agents; Isl | 2017 |
Urinary Metabolomic Profiling in Zucker Diabetic Fatty Rats with Type 2 Diabetes Mellitus Treated with Glimepiride, Metformin, and Their Combination.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Meta | 2016 |
Effect of Cichorium intybus L. seed extract on renal parameters in experimentally induced early and late diabetes type 2 in rats.
Topics: Animals; Blood Glucose; Cichorium intybus; Creatinine; Diabetes Mellitus, Experimental; Diabetic Nep | 2017 |
Metformin improves lipid metabolism disorders through reducing the expression of microsomal triglyceride transfer protein in OLETF rats.
Topics: Animals; Blotting, Western; Carrier Proteins; Diabetes Mellitus, Experimental; Diabetes Mellitus, Ty | 2016 |
Histological evidence that metformin reverses the adverse effects of diabetes on orthodontic tooth movement in rats.
Topics: Alkaline Phosphatase; Animals; Cathepsin K; Diabetes Complications; Diabetes Mellitus, Experimental; | 2017 |
Effect of hydroalcoholic Allium ampeloprasum extract on oxidative stress, diabetes mellitus and dyslipidemia in alloxan-induced diabetic rats.
Topics: Allium; Alloxan; Animals; Antioxidants; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental; | 2017 |
Metformin-loaded alginate nanoparticles as an effective antidiabetic agent for controlled drug release.
Topics: Alginates; Animals; Blood Glucose; Delayed-Action Preparations; Diabetes Mellitus, Experimental; Dru | 2017 |
The Short-term Effects of Insulin, Metformin and Insulin-Metformin Combination on the Liver Morphology in High Fat Diet / Streptozotocin Induced Diabetic Albino Rats.
Topics: Animals; Antibiotics, Antineoplastic; Diabetes Mellitus, Experimental; Diet, High-Fat; Fatty Liver; | 2016 |
Metformin enhancing the antitumor efficacy of carboplatin against Ehrlich solid carcinoma grown in diabetic mice: Effect on IGF-1 and tumoral expression of IGF-1 receptors.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carboplatin; Carcinoma, Ehrlich Tumor; Caspase 3; Cell Li | 2017 |
The Effects of Metformin on Obesity-Induced Dysfunctional Retinas.
Topics: Animals; Blood Glucose; Blotting, Western; Cytokines; Diabetes Mellitus, Experimental; Diabetes Mell | 2017 |
The Influence of Chitosan Cross-linking on the Properties of Alginate Microparticles with Metformin Hydrochloride-In Vitro and In Vivo Evaluation.
Topics: Alginates; Animals; Blood Glucose; Chemistry, Pharmaceutical; Chitosan; Cross-Linking Reagents; Dela | 2017 |
Metformin attenuates hepatic insulin resistance in type-2 diabetic rats through PI3K/Akt/GLUT-4 signalling independent to bicuculline-sensitive GABA
Topics: Androstadienes; Animals; Bicuculline; Calcium; Diabetes Mellitus, Experimental; Diabetes Mellitus, T | 2017 |
Telmisartan attenuates diabetes induced depression in rats.
Topics: Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Benzimidazoles; Benzoates; Brain; Depress | 2017 |
Tacrolimus in the prevention of adverse pregnancy outcomes and diabetes-associated embryopathies in obese and diabetic mice.
Topics: Animals; Bone and Bones; Diabetes Mellitus, Experimental; Diet, High-Fat; Female; Fetal Diseases; Gl | 2017 |
Pharmacological evaluation of aqueous extract of syzigium cumini for its antihyperglycemic and antidyslipidemic properties in diabetic rats fed a high cholesterol diet-Role of PPARγ and PPARα.
Topics: Animal Feed; Animals; Blood Glucose; Cholesterol, Dietary; Diabetes Mellitus, Experimental; Dietary | 2017 |
The effect of combined photobiomodulation and metformin on open skin wound healing in a non-genetic model of type II diabetes.
Topics: Animals; Colony Count, Microbial; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Low-Le | 2017 |
Effects of metformin on QT and QTc interval dispersion of diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Electrocardiography; Hea | 2008 |
Scutellaria baicalensis enhances the anti-diabetic activity of metformin in streptozotocin-induced diabetic Wistar rats.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Drug | 2008 |
Adiponectin receptors: expression in Zucker diabetic rats and effects of fenofibrate and metformin.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Eating; Fatty Acids, Nonesteri | 2008 |
Effect of FeSO4 treatment on glucose metabolism in diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Citric Acid Cycle; Diabetes Mellitus, Experimental; Electron Tr | 2008 |
Metabolic effects of various antidiabetic and hypolipidaemic agents on a high-fat diet and multiple low-dose streptozocin (MLDS) mouse model of diabetes.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dietary Fats; Fe | 2008 |
[Effects of Yuquan pills on pharmacokinetics of metformin hydrochloride in diabetic rats].
Topics: Animals; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experimental; Drug Interactions; D | 2008 |
Amelioration of metformin-induced hypothyroidism by Withania somnifera and Bauhinia purpurea extracts in Type 2 diabetic mice.
Topics: Animals; Bauhinia; Dexamethasone; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Female | 2009 |
db/+ Mice as an alternate model in antidiabetic drug discovery research.
Topics: Animals; Body Weight; Diabetes Mellitus, Experimental; Disease Models, Animal; Drug Discovery; Gluco | 2009 |
Antioxidant activity of chito-oligosaccharides on pancreatic islet cells in streptozotocin-induced diabetes in rats.
Topics: Animals; Antioxidants; Cell Line; Chitin; Chitosan; Diabetes Mellitus, Experimental; Glutathione Per | 2009 |
Diabetic cardiomyopathy: effects of fenofibrate and metformin in an experimental model--the Zucker diabetic rat.
Topics: Animals; Blood Glucose; Cardiomyopathies; Diabetes Mellitus, Experimental; Disease Models, Animal; F | 2009 |
Baicalin improves antioxidant status of streptozotocin-induced diabetic Wistar rats.
Topics: Animals; Antioxidants; Blood Glucose; Catalase; Diabetes Mellitus, Experimental; Flavonoids; Glutath | 2009 |
Lost in translation: modulation of the metabolic-functional relation in the diabetic human heart.
Topics: Animals; Diabetes Complications; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Fatty A | 2009 |
Assessment of genomic instability in normal and diabetic rats treated with metformin.
Topics: Animals; Chromosome Aberrations; Diabetes Mellitus, Experimental; Drug Administration Schedule; Geno | 2009 |
beta cell protecting and immunomodulatory activities of Paecilomyces Hepiali Chen mycelium in STZ induced T1DM mice.
Topics: Animals; Apoptosis; Blood Glucose; CD4-Positive T-Lymphocytes; Cell Proliferation; Diabetes Mellitus | 2009 |
Nonalcoholic hepatic steatosis in Zucker diabetic rats: spontaneous evolution and effects of metformin and fenofibrate.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Disease Models, Animal; Eating | 2009 |
Gastroprotective effects of the insulin sensitizers rosiglitazone and metformin against indomethacin-induced gastric ulcers in Type 2 diabetic rats.
Topics: Animals; Catalase; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dinoprostone; Gastric | 2010 |
Effect of metformin on bone marrow progenitor cell differentiation: in vivo and in vitro studies.
Topics: Animals; Blotting, Western; Bone Marrow Cells; Cell Differentiation; Cells, Cultured; Diabetes Melli | 2010 |
Effects of guggulsterone isolated from Commiphora mukul in high fat diet induced diabetic rats.
Topics: Animals; Anticholesteremic Agents; Blood Glucose; Commiphora; Diabetes Mellitus, Experimental; Diabe | 2009 |
Antidiabetic effects of Artemisia sphaerocephala Krasch. gum, a novel food additive in China, on streptozotocin-induced type 2 diabetic rats.
Topics: Animals; Artemisia; Blood Glucose; China; Cholesterol; Cholesterol, HDL; Diabetes Mellitus, Experime | 2009 |
Baicalin reduces mitochondrial damage in streptozotocin-induced diabetic Wistar rats.
Topics: Animals; Citrate (si)-Synthase; Diabetes Complications; Diabetes Mellitus, Experimental; Flavonoids; | 2009 |
Metformin normalizes type 2 diabetes-induced decrease in cell proliferation and neuroblast differentiation in the rat dentate gyrus.
Topics: Animals; Blood Glucose; Body Weight; Cell Proliferation; Dentate Gyrus; Diabetes Mellitus, Experimen | 2010 |
Genetic deletion or pharmacological inhibition of dipeptidyl peptidase-4 improves cardiovascular outcomes after myocardial infarction in mice.
Topics: Animals; Cardiovascular System; Coronary Vessels; Diabetes Mellitus, Experimental; Dipeptidyl Peptid | 2010 |
Metformin reverses hexokinase and 6-phosphofructo-1-kinase inhibition in skeletal muscle, liver and adipose tissues from streptozotocin-induced diabetic mouse.
Topics: Adipose Tissue; Animals; Biocatalysis; Cell Line; Diabetes Mellitus, Experimental; Drug Design; Glyc | 2010 |
Tectone, a new antihyperglycemic anthraquinone from Tectona grandis leaves.
Topics: Animals; Anthraquinones; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Magnetic Resonance Sp | 2010 |
Antioxidant protective effect of glibenclamide and metformin in combination with honey in pancreas of streptozotocin-induced diabetic rats.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Gene Expression Regulation, Enzymologic; Gly | 2010 |
Pioglitazone versus metformin in two rat models of glucose intolerance and diabetes.
Topics: Animals; Blood Glucose; Carbohydrate Metabolism; Diabetes Mellitus, Experimental; Dietary Fats; Gluc | 2010 |
Influence of metformin on GLUT1 gene and protein expression in rat streptozotocin diabetes mellitus model.
Topics: Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Gene Expression Regulation; Glucos | 2010 |
Antihyperglycemic effects of baicalin on streptozotocin - nicotinamide induced diabetic rats.
Topics: Adiponectin; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Flavonoids; Glycogen; Hexokina | 2011 |
Effect of Cyclea peltata Lam. roots aqueous extract on glucose levels, lipid profile, insulin, TNF-alpha and skeletal muscle glycogen in type 2 diabetic rats.
Topics: Animals; Blood Glucose; Cyclea; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Drug Eva | 2010 |
[Effect of metformin on the formation of hepatic fibrosis in type 2 diabetic rats].
Topics: Actins; Animals; Apoptosis; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetes Me | 2010 |
Polyphenols-rich Vernonia amygdalina shows anti-diabetic effects in streptozotocin-induced diabetic rats.
Topics: Animals; Antioxidants; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental; Dose-Response Re | 2011 |
Effect of metformin on renal microsomal proteins, lipid peroxidation and antioxidant status in dexamethasone-induced type-2 diabetic mice.
Topics: Animals; Catalase; Dexamethasone; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glutat | 2010 |
Insulin and metformin may prevent renal injury in young type 2 diabetic Goto-Kakizaki rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dia | 2011 |
Metformin and atorvastatin combination further protect the liver in type 2 diabetes with hyperlipidaemia.
Topics: Animals; Anticholesteremic Agents; Atorvastatin; Body Weight; C-Reactive Protein; Diabetes Complicat | 2011 |
Protection of cholinergic and antioxidant system contributes to the effect of berberine ameliorating memory dysfunction in rat model of streptozotocin-induced diabetes.
Topics: Acetylcholine; Administration, Oral; Analysis of Variance; Animals; Antioxidants; Ascorbic Acid; Ber | 2011 |
Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer's-like changes.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Line; Cholinesterases; Diabetes Mellitus, Ex | 2011 |
Comparison of antioxidant effects of honey, glibenclamide, metformin, and their combinations in the kidneys of streptozotocin-induced diabetic rats.
Topics: Animals; Antioxidants; Catalase; Diabetes Mellitus, Experimental; Glutathione Peroxidase; Glutathion | 2011 |
Glibenclamide or metformin combined with honey improves glycemic control in streptozotocin-induced diabetic rats.
Topics: Animals; Bilirubin; Blood Glucose; Body Weight; Creatinine; Diabetes Mellitus, Experimental; Eating; | 2011 |
Metformin attenuates streptozotocin-induced diabetic nephropathy in rats through modulation of oxidative stress genes expression.
Topics: Animals; Blood Glucose; Catalase; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Dose-Resp | 2011 |
A convenient synthesis of novel pyranosyl homo-C-nucleosides and their antidiabetic activities.
Topics: alpha-Glucosidases; Animals; Cyclization; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Glucos | 2011 |
Pectin from Passiflora edulis shows anti-inflammatory action as well as hypoglycemic and hypotriglyceridemic properties in diabetic rats.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases; Biomarkers; Ca | 2011 |
Effect of aspirin on the expression of hepatocyte NF-κB and serum TNF-α in streptozotocin-induced type 2 diabetic rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Glucose; Diabetes Mellitus, Experim | 2011 |
Hypoglycemic effects and biochemical mechanisms of oat products on streptozotocin-induced diabetic mice.
Topics: Animals; Avena; beta-Glucans; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Typ | 2011 |
The effect of metformin on the myocardial tolerance to ischemia-reperfusion injury in the rat model of diabetes mellitus type II.
Topics: Animals; Animals, Newborn; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Disease Mode | 2011 |
Hypoglycemic effects and constituents of the barks of Cyclocarya paliurus and their inhibiting activities to glucosidase and glycogen phosphorylase.
Topics: Animals; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Glucosidases; Glycogen Phosphorylase; H | 2011 |
Bitter melon extracts in diabetic and normal rats favorably influence blood glucose and blood pressure regulation.
Topics: Animals; Blood Glucose; Blood Pressure; Cucurbitaceae; Diabetes Mellitus, Experimental; Fruit; Gluco | 2011 |
Effect of aqueous extract of the leaves of Acalypha wilkesiana 'Godseffiana' Muell Arg (Euphorbiaceae) on the hematology, plasma biochemistry and ocular indices of oxidative stress in alloxan induced diabetic rats.
Topics: Animals; Antioxidants; Aspartate Aminotransferases; Bilirubin; Biomarkers; Blood Cell Count; Blood C | 2011 |
Hypoglycaemic activity and molecular mechanisms of Caesalpinia ferrea Martius bark extract on streptozotocin-induced diabetes in Wistar rats.
Topics: Acetyl-CoA Carboxylase; Administration, Oral; AMP-Activated Protein Kinases; Animals; Blood Glucose; | 2011 |
Role of activation of 5'-adenosine monophosphate-activated protein kinase in gastric ulcer healing in diabetic rats.
Topics: Acetic Acid; Animals; Blood Glucose; Cyclic AMP-Dependent Protein Kinases; Diabetes Mellitus, Experi | 2011 |
Reduction of insulin signaling upregulates angiopoietin-like protein 4 through elevated free fatty acids in diabetic mice.
Topics: 3T3-L1 Cells; Angiopoietin-Like Protein 4; Angiopoietins; Animals; Cell Line, Tumor; Diabetes Mellit | 2012 |
Sirtuin 1-mediated cellular metabolic memory of high glucose via the LKB1/AMPK/ROS pathway and therapeutic effects of metformin.
Topics: Adenylate Kinase; AMP-Activated Protein Kinase Kinases; Animals; bcl-2-Associated X Protein; Blood G | 2012 |
Antihyperglycemic and antihyperlipidemic effect of Santalum album in streptozotocin induced diabetic rats.
Topics: Administration, Oral; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Hypoglycemic Agents; | 2012 |
Antidiabetic effect of total saponins from Entada phaseoloides (L.) Merr. in type 2 diabetic rats.
Topics: Animals; Anti-Inflammatory Agents; Blood Glucose; Diabetes Mellitus, Experimental; Diet, High-Fat; D | 2012 |
Fenugreek attenuation of diabetic nephropathy in alloxan-diabetic rats: attenuation of diabetic nephropathy in rats.
Topics: Alloxan; Animals; Anti-Inflammatory Agents; Antioxidants; Catalase; Diabetes Mellitus, Experimental; | 2012 |
Anti-inflammatory and anti-hyperlipidemic effect of Semecarpus anacardium in a high fat diet: STZ-induced type 2 diabetic rat model.
Topics: Animals; Anti-Inflammatory Agents; C-Reactive Protein; Diabetes Mellitus, Experimental; Diabetes Mel | 2013 |
The effect of metformin on food intake and its potential role in hypothalamic regulation in obese diabetic rats.
Topics: Administration, Oral; Agouti-Related Protein; AMP-Activated Protein Kinases; Animals; Blood Glucose; | 2012 |
Anti-diabetic activities of Acanthopanax senticosus polysaccharide (ASP) in combination with metformin.
Topics: Animals; Bilirubin; Blood Glucose; Body Weight; Creatinine; Diabetes Mellitus, Experimental; Drug In | 2012 |
Pharmacokinetic and pharmacodynamic evaluation of floating microspheres of metformin hydrochloride.
Topics: Analysis of Variance; Animals; Biological Availability; Diabetes Mellitus, Experimental; Glucose Tol | 2013 |
Hypoglycemic effect and mechanism of a proteoglycan from ganoderma lucidum on streptozotocin-induced type 2 diabetic rats.
Topics: Animals; Blood Glucose; Blotting, Western; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type | 2012 |
Antidiabetic and antioxidant effect of Semecarpus anacardium Linn. nut milk extract in a high-fat diet STZ-induced type 2 diabetic rat model.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Diet; Dietary Fats; Flavonoid | 2012 |
Bioassay-guided antidiabetic study of Phaleria macrocarpa fruit extract.
Topics: Animals; Biological Assay; Biological Transport; Blood Glucose; Chemical Fractionation; Diabetes Mel | 2012 |
Potential antidiabetic effect of the Semecarpus anacardium in a type 2 diabetic rat model.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Di | 2013 |
Methazolamide is a new hepatic insulin sensitizer that lowers blood glucose in vivo.
Topics: Animals; Blood Glucose; Carbonic Anhydrase Inhibitors; Diabetes Mellitus, Experimental; Glucose Clam | 2012 |
Glibenclamide-pregnenolone derivative has greater hypoglycemic effects and biodistribution than glibenclamide-OH in alloxan-rats.
Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Drug Combinations; Female; Glyburi | 2012 |
Metformin reverses hexokinase and phosphofructokinase downregulation and intracellular distribution in the heart of diabetic mice.
Topics: Animals; Blood Glucose; Cardiotonic Agents; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathi | 2012 |
Antihyperglycemic activity of extracts from Boldoa purpurascens leaves in alloxan-induced diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Inositol; Male; Metfor | 2013 |
Central anti-diabetic action of biguanide and thizolidinediones in D-glucose fed and streptozotocin-treated mouse models.
Topics: Animals; Biguanides; Blood Glucose; Brain; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type | 2012 |
Oral administration of puerh tea polysaccharides lowers blood glucose levels and enhances antioxidant status in alloxan-induced diabetic mice.
Topics: Administration, Oral; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Hypogly | 2012 |
Obestatin induced recovery of myocardial dysfunction in type 1 diabetic rats: underlying mechanisms.
Topics: AMP-Activated Protein Kinases; Animals; Blotting, Western; Cardiotonic Agents; Cell Line; Diabetes M | 2012 |
Gemfibrozil and its combination with metformin on pleiotropic effect on IL-10 and adiponectin and anti-atherogenic treatment in insulin resistant type 2 diabetes mellitus rats.
Topics: Adiponectin; Animals; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Drug | 2013 |
Chronic metformin associated cardioprotection against infarction: not just a glucose lowering phenomenon.
Topics: Aging; AMP-Activated Protein Kinase Kinases; Animals; Blood Glucose; Blotting, Western; Cardiotonic | 2013 |
Sargassum polycystum reduces hyperglycaemia, dyslipidaemia and oxidative stress via increasing insulin sensitivity in a rat model of type 2 diabetes.
Topics: Animals; Cholesterol; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Di | 2013 |
Fenugreek seed mucilage-alginate mucoadhesive beads of metformin HCl: Design, optimization and evaluation.
Topics: Adhesiveness; Administration, Oral; Alginates; Animals; Blood Glucose; Chemistry, Pharmaceutical; Di | 2013 |
Pharmacokinetic-pharmacodynamic analysis of the glucose-lowering effect of metformin in diabetic rats reveals first-pass pharmacodynamic effect.
Topics: Animals; Blood Glucose; Chromatography, High Pressure Liquid; Cross-Over Studies; Diabetes Mellitus, | 2002 |
Increase of insulin sensitivity in diabetic rats received die-huang-wan, a herbal mixture used in Chinese traditional medicine.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Drug Interactions; Drugs, Chinese Herbal; H | 2002 |
Bioadhesive delivery of metformin using prosopis gum with antidiabetic potential.
Topics: Adhesives; Administration, Cutaneous; Animals; Area Under Curve; Biological Availability; Biological | 2003 |
Mild acute renal failure potentiates metformin accumulation in the diabetic rat kidney without further impairment of renal function.
Topics: Acute Kidney Injury; Animals; Blood Pressure; Creatinine; Diabetes Mellitus, Experimental; Hypoglyce | 2003 |
[EFFECTS OF VARIOUS NATURAL ORGANIC SUBSTANCES AND AMINO ACIDS ON THE BLOOD SURGAR LEVEL AND EXPERIMENTAL STUDIES ON ORAL HYPOGLYCEMIC AGENTS].
Topics: Amino Acids; Animals; Bile Acids and Salts; Blood Chemical Analysis; Blood Glucose; Caffeine; Chlorp | 1963 |
Pharmacodynamic-pharmacokinetic profiles of metformin hydrochloride from a mucoadhesive formulation of a polysaccharide with antidiabetic property in streptozotocin-induced diabetic rat models.
Topics: Adhesiveness; Animals; Blood Glucose; Chemistry, Pharmaceutical; Culture Techniques; Diabetes Mellit | 2004 |
[2-year data of large clinical comparative studies. Type 2 diabetes: lasting metabolic control with pioglitazone].
Topics: Animals; Clinical Trials as Topic; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Drug | 2004 |
Effect of N-benzoyl-D-phenylalanine and metformin on carbohydrate metabolic enzymes in neonatal streptozotocin diabetic rats.
Topics: Animals; Animals, Newborn; Blood Glucose; Body Weight; Carbohydrate Metabolism; Diabetes Mellitus, E | 2005 |
Effect of N-benzoyl-D-phenylalanine on streptozotocin-induced changes in the lipid and lipoprotein profile in rats.
Topics: Animals; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental; Drug Therapy, Combination; Fat | 2005 |
Effect of Sanguis draxonis (a Chinese traditional herb) on the formation of insulin resistance in rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Drugs, Chinese Herbal; Hypoglycemic Agents; | 2005 |
Protective effects of metformin treatment on the liver injury of streptozotocin-diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Female; Hypoglycemic Agents; Liver; Liver Function Tests; | 2005 |
Metformin treatment restores the altered microvascular reactivity in neonatal streptozotocin-induced diabetic rats increasing NOS activity, but not NOS expression.
Topics: Animals; Animals, Newborn; Body Weight; Capillaries; Diabetes Mellitus, Experimental; Eating; Glucos | 2005 |
Hypoglycemic effect of Malmea depressa root on streptozotocin diabetic rats.
Topics: Animals; Annonaceae; Blood Glucose; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experim | 2005 |
Effect of N-benzoyl-d-phenylalanine on lipid profile in liver of neonatal streptozotocin diabetic rats.
Topics: Administration, Oral; Animals; Animals, Newborn; Blood Glucose; Diabetes Mellitus, Experimental; Dia | 2005 |
Effect of rosiglitazone and nateglinide on serum glucose and lipid profile alone or in combination with the biguanide metformin in diabetic rats.
Topics: Animals; Blood Glucose; Blood Proteins; Cholesterol; Cyclohexanes; Diabetes Mellitus, Experimental; | 2006 |
Effects of insulin sensitizers on islet transplantation.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Insulin; Insulin Secre | 2005 |
Metformin reduces blood pressure and restores endothelial function in aorta of streptozotocin-induced diabetic rats.
Topics: 4-Aminopyridine; Acetylcholine; Animals; Aorta, Thoracic; Blood Pressure; Diabetes Mellitus, Experim | 2006 |
Novel mechanism for plasma glucose-lowering action of metformin in streptozotocin-induced diabetic rats.
Topics: Adrenalectomy; Animals; beta-Endorphin; Blood Glucose; Diabetes Mellitus, Experimental; Glucose Tran | 2006 |
[Effects of metformin on endothelial dysfunction of the renal circulation resulting from acute hyperglycemia in non-diabetic rabbits].
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dose-Response Relationship, Dru | 2005 |
[From cancer to diabetes treatment : the tumor suppressor LKB1 as a new pharmacological target].
Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Animals; Cyclic AMP Response El | 2006 |
Combined n-benzoyl-d-phenylalanine and metformin treatment reverses changes in the fatty acid composition of streptozotocin diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Drug Therapy, Combination; Fatty Acids; Fat | 2006 |
Global gene expression analysis in liver of obese diabetic db/db mice treated with metformin.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Gene Expr | 2006 |
Association of insulin resistance with hyperglycemia in streptozotocin-diabetic pigs: effects of metformin at isoenergetic feeding in a type 2-like diabetic pig model.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Eating; Glucose; Glycosuria; Hy | 2006 |
Metformin-like effect of Salvia officinalis (common sage): is it useful in diabetes prevention?
Topics: Animals; Beverages; Blood Glucose; Cells, Cultured; Diabetes Mellitus, Experimental; Female; Glucago | 2006 |
Effects of glibornuride versus metformin on eye lenses and skin in experimental diabetes.
Topics: Animals; Blood Glucose; Body Weight; Crystallins; Diabetes Mellitus, Experimental; Electrophoresis, | 2006 |
Succinic acid monoethyl ester, a novel insulinotropic agent: effect on lipid composition and lipid peroxidation in streptozotocin-nicotin-amide induced type 2 diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Humans; Hypoglycemic Agents; Insulin; Kidne | 2007 |
A role for AMP-activated protein kinase in diabetes-induced renal hypertrophy.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Carrier Proteins; Cells, Culture | 2007 |
Effect of N-benzoyl-D-phenylalanine and metformin on insulin receptors in neonatal streptozotocin-induced diabetic rats: studies on insulin binding to erythrocytes.
Topics: Animals; Animals, Newborn; Binding, Competitive; Blood Glucose; Diabetes Mellitus, Experimental; Ery | 2006 |
Effect of Sclerocarya birrea (Anacardiaceae) stem bark methylene chloride/methanol extract on streptozotocin-diabetic rats.
Topics: Anacardiaceae; Animals; Blood Glucose; Cameroon; Cholesterol; Diabetes Mellitus, Experimental; Gluco | 2007 |
Anti-diabetic effects of Cichorium intybus in streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Cholesterol; Cichorium intybus; Diabetes Mellitus, Experimental; Drug Evalua | 2007 |
Maternal diabetes adversely affects AMP-activated protein kinase activity and cellular metabolism in murine oocytes.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Acetyl-CoA Carboxylase; Adenosine Monophosphate; Adenosine Triphos | 2007 |
The antidiabetic effects of cysteinyl metformin, a newly synthesized agent, in alloxan- and streptozocin-induced diabetic rats.
Topics: Alloxan; Animals; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental; Hypoglycemic Agents; | 2008 |
Changes in metformin pharmacokinetics after intravenous and oral administration to rats with short-term and long-term diabetes induced by streptozotocin.
Topics: Administration, Oral; Animals; Area Under Curve; Blood Proteins; Chromatography, High Pressure Liqui | 2008 |
Effects of diabetes mellitus induced by alloxan on the pharmacokinetics of metformin in rats: restoration of pharmacokinetic parameters to the control state by insulin treatment.
Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Insulin; Male; Metabolic Clearance Rate; Metformi | 2008 |
Effect of succinic acid monoethyl ester on hemoglobin glycation and tail tendon collagen properties in type 2 diabetic rats.
Topics: Animals; Blood Glucose; Collagen; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glycat | 2008 |
Effect of metformin on hepatocyte insulin receptor binding in normal, streptozotocin diabetic and genetically obese diabetic (ob/ob) mice.
Topics: Animals; Binding Sites; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Insulin; | 1983 |
[Hypoglycemic effects of the blended Chinese traditional medicines in genetically and chemically diabetic mice].
Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glyburide; Hypoglycemic Agents; Ma | 1984 |
Plasma high density lipoprotein cholesterol in streptozotocin diabetic and non-diabetic mice after prolonged administration of glibenclamide, chlorpropamide and metformin.
Topics: Animals; Blood Glucose; Body Weight; Chlorpropamide; Cholesterol; Cholesterol, HDL; Diabetes Mellitu | 1981 |
Changes in hepatic and intestinal cholesterol regulatory enzymes. The influence of metformin.
Topics: Acyltransferases; Animals; Cholesterol; Diabetes Mellitus, Experimental; Hydroxymethylglutaryl CoA R | 1983 |
Pharmacologic effects of metformin in relation to its disposition in alloxan diabetic rats.
Topics: Administration, Oral; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucose Tolerance Tes | 1983 |
[Endocrine pancreatic regeneration in diabetic mouse DBM. An ultrastructural and histoenzymological study (author's transl)].
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Hyperplasia; Insulin; Islets of Lan | 1981 |
Metformin-induced lactic acidosis: potentiation by ethanol.
Topics: Acidosis; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Drug Synergism; Ethanol; Fasting; | 1981 |
Hb AIc measurement in the investigation of hypoglycemic drugs in mice: a study with metformin.
Topics: Age Factors; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Glycosides; Hemoglobin | 1981 |
Action of metformin on glucose transport and glucose transporter GLUT1 and GLUT4 in heart muscle cells from healthy and diabetic rats.
Topics: Animals; Biological Transport; Cells, Cultured; Diabetes Mellitus, Experimental; Drug Interactions; | 1995 |
[An animal model for testing hypoglycemic and hypolipidemic drugs].
Topics: Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Drugs, Chinese Herbal; Hyperlipide | 1994 |
Effects of metformin on glucose and glucagon regulated gluconeogenesis in cultured normal and diabetic hepatocytes.
Topics: Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Glucagon; Gluconeogenesis; Glucose; Liver | 1994 |
Metformin improves cardiac function in isolated streptozotocin-diabetic rat hearts.
Topics: Animals; Blood Glucose; Blood Pressure; Diabetes Mellitus, Experimental; Heart; Heart Rate; In Vitro | 1994 |
Accumulation of metformin by tissues of the normal and diabetic mouse.
Topics: Administration, Oral; Animals; Diabetes Mellitus, Experimental; Digestive System; Injections, Intrav | 1994 |
Antihyperglycemic action of guanidinoalkanoic acids: 3-guanidinopropionic acid ameliorates hyperglycemia in diabetic KKAy and C57BL6Job/ob mice and increases glucose disappearance in rhesus monkeys.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, | 1993 |
Metformin does not increase energy expenditure of brown fat.
Topics: Adipose Tissue, Brown; Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Electron Transport | 1993 |
Studies on pyrazinoylguanidine. 2. Comparative drug and dose effects on glucose and lipid metabolism in streptozotocin-induced diabetic rats.
Topics: Analysis of Variance; Animals; Anti-Bacterial Agents; Blood Glucose; Diabetes Mellitus, Experimental | 1996 |
The effect of metformin on insulin receptors and lipid peroxidation in alloxan and streptozotocin induced diabetes.
Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Insulin; Lipi | 1995 |
Increased alanine uptake and lipid synthesis from alanine in isolated hepatocytes of Wistar-Kyoto fatty rats: an inhibitory effect of biguanides.
Topics: Aging; Alanine; Animals; Body Weight; Buformin; Cells, Cultured; Diabetes Mellitus, Experimental; Di | 1997 |
Effects of insulin and the combination of insulin plus metformin (glucophage) on microvascular reactivity in control and diabetic hamsters.
Topics: Administration, Topical; Animals; Arterioles; Cheek; Cricetinae; Diabetes Mellitus, Experimental; Do | 1997 |
Effect of peroxovanadate compound on phosphoenolpyruvate carboxykinase gene expression and lipid metabolism in diabetic rats.
Topics: Analysis of Variance; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Gene Expression Regul | 1997 |
Nongenetic mouse models of non-insulin-dependent diabetes mellitus.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dietary Fats; Di | 1998 |
The influence of streptozotocin-induced diabetes and the antihyperglycaemic agent metformin on the contractile characteristics and the membrane potential of the rat diaphragm.
Topics: Animals; Diabetes Mellitus, Experimental; Diaphragm; Hypoglycemic Agents; Isometric Contraction; Mal | 1998 |
Effect of masoprocol on carbohydrate and lipid metabolism in a rat model of Type II diabetes.
Topics: Adipocytes; Animals; Antioxidants; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diab | 1999 |
Modifications of citric acid cycle activity and gluconeogenesis in streptozotocin-induced diabetes and effects of metformin.
Topics: Animals; Citric Acid Cycle; Diabetes Mellitus, Experimental; Gluconeogenesis; Glucose; Glutamic Acid | 1999 |
Effect of metformin on advanced glycation endproduct formation and peripheral nerve function in streptozotocin-induced diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Glycation End Products, Advanced; Hypoglycemic Agents; Kid | 1999 |
The influence of streptozotocin diabetes and metformin on erythrocyte volume and on the membrane potential and the contractile characteristics of the extensor digitorum longus and soleus muscles in rats.
Topics: Animals; Diabetes Mellitus, Experimental; Erythrocyte Volume; Hematologic Tests; Hypoglycemic Agents | 1999 |
Vanadyl-biguanide complexes as potential synergistic insulin mimics.
Topics: Animals; Biguanides; Blood Glucose; Diabetes Mellitus, Experimental; Drug Synergism; Humans; Hypogly | 1999 |
Effects of Averrhoa bilimbi leaf extract on blood glucose and lipids in streptozotocin-diabetic rats.
Topics: Animals; Antioxidants; Blood Glucose; Body Water; Cytochrome P-450 Enzyme System; Diabetes Mellitus, | 2000 |
Preparation and characterisation of rose Bengal-loaded surface-modified albumin nanoparticles.
Topics: Administration, Oral; Animals; Area Under Curve; Blood Glucose; Chromatography, High Pressure Liquid | 2001 |
Preclinical evaluation of pharmacokinetic-pharmacodynamic rationale for oral CR metformin formulation.
Topics: Administration, Oral; Animals; Area Under Curve; Blood Glucose; Chromatography, High Pressure Liquid | 2001 |
Anti-diabetic property of ethanolic extract of Andrographis paniculata in streptozotocin-diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Drugs, Chinese Herbal; Glucose Tolerance Te | 2000 |
Metformin-like effects of Quei Fu Di Huang Wan, a Chinese herbal mixture, on streptozotocin-induced diabetic rat.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Drugs, Chinese Herbal; Gene Expression; Hyp | 2001 |
Reversal of diabetes-induced rat graft transplant coronary artery disease by metformin.
Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Coronary Disease; Diabetes Mellitus, Experimental; | 2002 |
DBM mice as a pharmacological model of maturity onset diabetes. Studies with metformin.
Topics: Aging; Animals; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Experimental; Disease Models, A | 1979 |
In vivo glycogen and lipid synthesis by various tissues from normal and metformin-treated KK mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucose; Glycogen; Insulin; Lipids; Male; M | 1992 |
Effect of chronic metformin treatment of hepatic and muscle glycogen metabolism in KK mice.
Topics: Analysis of Variance; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glycogen; Glycogen Sy | 1992 |
Sites of metformin-stimulated glucose metabolism.
Topics: Adipose Tissue; Aerobiosis; Anaerobiosis; Animals; Blood Glucose; Carbon Dioxide; Diabetes Mellitus, | 1990 |
Effect of metformin treatment on insulin action in diabetic rats: in vivo and in vitro correlations.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Eating; Fasting; Glucose; Histones; Insulin | 1990 |
Postreceptor effect of metformin on insulin action in mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Insulin; Iodine Radioisotopes; Liver Glycog | 1985 |
Treatment of streptozotocin-diabetic rats with metformin restores the ability of insulin to inhibit adenylate cyclase activity and demonstrates that insulin does not exert this action through the inhibitory guanine nucleotide regulatory protein Gi.
Topics: Adenylyl Cyclase Inhibitors; Animals; Cell Membrane; Diabetes Mellitus, Experimental; Glucagon; GTP- | 1988 |
Effect of metformin on glucose metabolism in mouse soleus muscle.
Topics: Animals; Diabetes Mellitus, Experimental; Glucose; Male; Metformin; Mice; Muscles; Receptor, Insulin | 1986 |
Studies on the effect of oral hypoglycaemic agents on hepatic glycogenolysis.
Topics: Acetohexamide; Animals; Blood Glucose; Depression, Chemical; Diabetes Mellitus, Experimental; Glucos | 1974 |
Effects of metformin on glucose uptake by isolated diaphragm from normal and diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Diaphragm; Fatty Acids, Nonesterified; Glucose; Glycogen; | 1972 |
Effects of metformin on glucose uptake by the isolated rat diaphragm.
Topics: Animals; Diabetes Mellitus, Experimental; Diaphragm; Fatty Acids, Nonesterified; Glucose; Glycolysis | 1972 |