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metformin and Alcoholic Liver Diseases

metformin has been researched along with Alcoholic Liver Diseases in 5 studies

Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.

Research Excerpts

ExcerptRelevanceReference
"Treatment with metformin attenuated the severity of liver injury, restored AMPK activity and normalized the expression of acetyl-CoA carboxylase and fatty acid synthase."5.40Involvement of insulin resistance in the protective effect of metformin against alcoholic liver injury. ( Jiang, Z; Nanji, AA; Wang, W; Zhao, C; Zhen, Z; Zhou, D; Zhou, J; Zhu, Z, 2014)
" Metformin serves as an AMPK activator and has been shown to have lipids lowering effects in non-alcoholic fatty liver disease (NAFLD), but its role in ALD remains unclear."4.12Metformin protects against ethanol-induced liver triglyceride accumulation by the LKB1/AMPK/ACC pathway. ( Lv, Y; So, KF; Wang, D; Xiao, J; Xie, F; Zhong, Y, 2022)
"Treatment with metformin attenuated the severity of liver injury, restored AMPK activity and normalized the expression of acetyl-CoA carboxylase and fatty acid synthase."1.40Involvement of insulin resistance in the protective effect of metformin against alcoholic liver injury. ( Jiang, Z; Nanji, AA; Wang, W; Zhao, C; Zhen, Z; Zhou, D; Zhou, J; Zhu, Z, 2014)
"Diabetes mellitus is an alarming life style disease in the modern world."1.38Hepatorenal repercussions of alcoholic exposure in a rat model: a dose-dependent study of metformin intervention. ( Bodhankar, SL; Borole, KD; Dawane, JS; Kanwal, JK, 2012)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's3 (60.00)24.3611
2020's1 (20.00)2.80

Authors

AuthorsStudies
Xie, F1
Zhong, Y1
Wang, D1
So, KF1
Xiao, J1
Lv, Y1
Zhou, DF1
Zhou, JY1
Dong, RQ1
Xing, WL1
Zhu, Z1
Jiang, Z1
Zhou, J1
Zhou, D1
Wang, W1
Zhao, C1
Zhen, Z1
Nanji, AA1
Donadon, V1
Balbi, M1
Zanette, G1
Borole, KD1
Bodhankar, SL1
Dawane, JS1
Kanwal, JK1

Other Studies

5 other studies available for metformin and Alcoholic Liver Diseases

ArticleYear
Metformin protects against ethanol-induced liver triglyceride accumulation by the LKB1/AMPK/ACC pathway.
    Molecular biology reports, 2022, Volume: 49, Issue:8

    Topics: AMP-Activated Protein Kinases; Animals; Ethanol; Lipid Metabolism; Liver; Liver Diseases, Alcoholic;

2022
[Protective effect and mechanism of metformin in rats with alcoholic liver disease].
    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2012, Volume: 20, Issue:12

    Topics: Animals; Insulin Resistance; Liver Diseases, Alcoholic; Male; Metformin; Rats; Rats, Wistar

2012
Involvement of insulin resistance in the protective effect of metformin against alcoholic liver injury.
    Alcoholism, clinical and experimental research, 2014, Volume: 38, Issue:6

    Topics: Adiponectin; Animals; Dose-Response Relationship, Drug; Ethanol; Hypoglycemic Agents; Insulin Resist

2014
Hyperinsulinemia and risk for hepatocellular carcinoma in patients with chronic liver diseases and Type 2 diabetes mellitus.
    Expert review of gastroenterology & hepatology, 2009, Volume: 3, Issue:5

    Topics: Carcinoma, Hepatocellular; Diabetes Mellitus, Type 2; Female; Hepatitis C, Chronic; Humans; Hyperins

2009
Hepatorenal repercussions of alcoholic exposure in a rat model: a dose-dependent study of metformin intervention.
    Iranian biomedical journal, 2012, Volume: 16, Issue:2

    Topics: Animals; Diabetes Mellitus; Ethanol; Hypoglycemic Agents; Kidney; Liver; Liver Diseases, Alcoholic;

2012