metformin has been researched along with Alcoholic Liver Diseases in 5 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with metformin attenuated the severity of liver injury, restored AMPK activity and normalized the expression of acetyl-CoA carboxylase and fatty acid synthase." | 5.40 | Involvement of insulin resistance in the protective effect of metformin against alcoholic liver injury. ( Jiang, Z; Nanji, AA; Wang, W; Zhao, C; Zhen, Z; Zhou, D; Zhou, J; Zhu, Z, 2014) |
| " Metformin serves as an AMPK activator and has been shown to have lipids lowering effects in non-alcoholic fatty liver disease (NAFLD), but its role in ALD remains unclear." | 4.12 | Metformin protects against ethanol-induced liver triglyceride accumulation by the LKB1/AMPK/ACC pathway. ( Lv, Y; So, KF; Wang, D; Xiao, J; Xie, F; Zhong, Y, 2022) |
| "Treatment with metformin attenuated the severity of liver injury, restored AMPK activity and normalized the expression of acetyl-CoA carboxylase and fatty acid synthase." | 1.40 | Involvement of insulin resistance in the protective effect of metformin against alcoholic liver injury. ( Jiang, Z; Nanji, AA; Wang, W; Zhao, C; Zhen, Z; Zhou, D; Zhou, J; Zhu, Z, 2014) |
| "Diabetes mellitus is an alarming life style disease in the modern world." | 1.38 | Hepatorenal repercussions of alcoholic exposure in a rat model: a dose-dependent study of metformin intervention. ( Bodhankar, SL; Borole, KD; Dawane, JS; Kanwal, JK, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xie, F | 1 |
| Zhong, Y | 1 |
| Wang, D | 1 |
| So, KF | 1 |
| Xiao, J | 1 |
| Lv, Y | 1 |
| Zhou, DF | 1 |
| Zhou, JY | 1 |
| Dong, RQ | 1 |
| Xing, WL | 1 |
| Zhu, Z | 1 |
| Jiang, Z | 1 |
| Zhou, J | 1 |
| Zhou, D | 1 |
| Wang, W | 1 |
| Zhao, C | 1 |
| Zhen, Z | 1 |
| Nanji, AA | 1 |
| Donadon, V | 1 |
| Balbi, M | 1 |
| Zanette, G | 1 |
| Borole, KD | 1 |
| Bodhankar, SL | 1 |
| Dawane, JS | 1 |
| Kanwal, JK | 1 |
5 other studies available for metformin and Alcoholic Liver Diseases
| Article | Year |
|---|---|
Metformin protects against ethanol-induced liver triglyceride accumulation by the LKB1/AMPK/ACC pathway.
Topics: AMP-Activated Protein Kinases; Animals; Ethanol; Lipid Metabolism; Liver; Liver Diseases, Alcoholic; | 2022 |
[Protective effect and mechanism of metformin in rats with alcoholic liver disease].
Topics: Animals; Insulin Resistance; Liver Diseases, Alcoholic; Male; Metformin; Rats; Rats, Wistar | 2012 |
Involvement of insulin resistance in the protective effect of metformin against alcoholic liver injury.
Topics: Adiponectin; Animals; Dose-Response Relationship, Drug; Ethanol; Hypoglycemic Agents; Insulin Resist | 2014 |
Hyperinsulinemia and risk for hepatocellular carcinoma in patients with chronic liver diseases and Type 2 diabetes mellitus.
Topics: Carcinoma, Hepatocellular; Diabetes Mellitus, Type 2; Female; Hepatitis C, Chronic; Humans; Hyperins | 2009 |
Hepatorenal repercussions of alcoholic exposure in a rat model: a dose-dependent study of metformin intervention.
Topics: Animals; Diabetes Mellitus; Ethanol; Hypoglycemic Agents; Kidney; Liver; Liver Diseases, Alcoholic; | 2012 |