metformin has been researched along with Alcohol Drinking in 11 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Alcohol Drinking: Behaviors associated with the ingesting of ALCOHOLIC BEVERAGES, including social drinking.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We report three cases of prospectively identified laboratory confirmed metformin-associated lactic acidosis admitted to our intensive care unit." | 7.91 | Laboratory-Confirmed Metformin-Associated Lactic Acidosis ( Canavan, C; Coyle, N; Nasim, S; Nestor, C, 2019) |
| " The main risk factors for developing HCC are well known and include hepatitis B and C virus infection, alcohol intake and ingestion of the fungal metabolite aflatoxin B1." | 4.93 | Hepatocellular carcinoma. ( Gores, G; Llovet, JM; Pikarsky, E; Sangro, B; Schwartz, M; Sherman, M; Zucman-Rossi, J, 2016) |
| " We report three cases of prospectively identified laboratory confirmed metformin-associated lactic acidosis admitted to our intensive care unit." | 3.91 | Laboratory-Confirmed Metformin-Associated Lactic Acidosis ( Canavan, C; Coyle, N; Nasim, S; Nestor, C, 2019) |
| "Treatment with metformin was less effective than lifestyle modifications, resulting in an average reduction of risk for development of type 2 diabetes by 31% compared with placebo." | 2.42 | [Progress in the prevention of type 2 diabetes]. ( Schernthaner, G, 2003) |
| "Metformin can cause serum vitamin B12 deficiency, but studies on the influence of its duration and dose are lacking." | 1.51 | Association between metformin dose and vitamin B12 deficiency in patients with type 2 diabetes. ( Ahn, CW; Fang, S; Kim, J; Lee, HS; Park, JS, 2019) |
| "Hippocampus-based learning and memory deficits are key symptoms of FASD." | 1.48 | Hippocampus-dependent memory and allele-specific gene expression in adult offspring of alcohol-consuming dams after neonatal treatment with thyroxin or metformin. ( Ferreira, A; Lim, PH; Redei, EE; Tunc-Ozcan, E; Wert, SL, 2018) |
| "Metformin-treated patients, especially elderly ones, are at a risk of sudden deterioration of renal function, which in turn may increase the risk of lactic acidosis." | 1.39 | Lactic acidosis in patients with diabetes. ( Karnafel, W; Krzymień, J, 2013) |
| "2) In patients with type 2 diabetes age, GFR and the consumption of fruit and vegetables were strong and independent determinants of plasma tHcy levels." | 1.33 | Plasma homocysteine levels in patients with type 2 diabetes in a Mediterranean population: relation with nutritional and other factors. ( Diakoumopoulou, E; Doulgerakis, D; Katsilambros, N; Kirlaki, E; Kitsou, E; Perrea, D; Psallas, M; Tentolouris, N, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (36.36) | 29.6817 |
| 2010's | 6 (54.55) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Nestor, C | 1 |
| Nasim, S | 1 |
| Coyle, N | 1 |
| Canavan, C | 1 |
| Kim, J | 1 |
| Ahn, CW | 1 |
| Fang, S | 1 |
| Lee, HS | 1 |
| Park, JS | 1 |
| Baradaran, Z | 1 |
| Vakilian, A | 1 |
| Zare, M | 1 |
| Hashemzehi, M | 1 |
| Hosseini, M | 1 |
| Dinpanah, H | 1 |
| Beheshti, F | 1 |
| Tunc-Ozcan, E | 1 |
| Wert, SL | 1 |
| Lim, PH | 1 |
| Ferreira, A | 1 |
| Redei, EE | 1 |
| Chao, DT | 1 |
| Shah, NH | 1 |
| Zeh, HJ | 1 |
| Bahary, N | 1 |
| Whitcomb, DC | 1 |
| Brand, RE | 1 |
| Llovet, JM | 1 |
| Zucman-Rossi, J | 1 |
| Pikarsky, E | 1 |
| Sangro, B | 1 |
| Schwartz, M | 1 |
| Sherman, M | 1 |
| Gores, G | 1 |
| Crandall, JP | 1 |
| Polsky, S | 1 |
| Howard, AA | 1 |
| Perreault, L | 1 |
| Bray, GA | 1 |
| Barrett-Connor, E | 1 |
| Brown-Friday, J | 1 |
| Whittington, T | 1 |
| Foo, S | 1 |
| Ma, Y | 1 |
| Edelstein, SL | 1 |
| Krzymień, J | 1 |
| Karnafel, W | 1 |
| Schernthaner, G | 1 |
| Diakoumopoulou, E | 1 |
| Tentolouris, N | 1 |
| Kirlaki, E | 1 |
| Perrea, D | 1 |
| Kitsou, E | 1 |
| Psallas, M | 1 |
| Doulgerakis, D | 1 |
| Katsilambros, N | 1 |
| Norman, RJ | 1 |
| Homan, G | 1 |
| Moran, L | 1 |
| Noakes, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Diabetes Prevention Program Outcomes Study[NCT00038727] | Phase 3 | 2,779 participants (Actual) | Interventional | 2002-09-30 | Active, not recruiting | ||
| Descriptive, Transversal Study of Evaluation of Cardiovascular Risks Factors and Prevalence of Metabolic Syndrome in the Different Phenotypes of Women With Polycystic Ovary Syndrome[NCT00784615] | 80 participants (Anticipated) | Observational | 2007-12-31 | Recruiting | |||
| Clinical Metabolic and Endocrine Parameters in Response to Metformin and Lifestyle Intervention in Women With Polycystic Ovary Syndrome: A Phase 4 Randomized, Double- Blind and Placebo Control Trial[NCT00679679] | Phase 4 | 30 participants (Actual) | Interventional | 2003-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Primary outcome for years 2002-2008 defined according to American Diabetes Association criteria (fasting plasma glucose level >= 126 mg/dL [7.0 mmol/L] or 2-hour plasma glucose >= 200 mg/dL [11.1 mmol/L], after a 75 gram oral glucose tolerance test (OGTT), and confirmed with a repeat test). (NCT00038727)
Timeframe: Outcomes were assessed from 1996-2008 (approximately 12 years including 6 years of DPP).
| Intervention | diabetes incidence (cases per 100 person (Number) |
|---|---|
| 1 Original Lifestyle | 5.3 |
| 2 Original Metformin | 6.4 |
| 3 Original Placebo | 7.8 |
All cause-mortality through clinic reports and National Death Index search (NCT00038727)
Timeframe: Outcomes were assessed throughout follow-up from 1996 to 2022. National Death Index search conducted in 2019 using early release data as of Dec 2018.
| Intervention | Participants (Count of Participants) |
|---|---|
| 1 Original Lifestyle | 158 |
| 2 Original Metformin | 152 |
| 3 Original Placebo | 143 |
Aggregate microvascular disease is defined as the average prevalence of 3 components: (1) retinopathy measured by photography (ETDRS of 20 or greater); (2) neuropathy detected by Semmes Weinstein 10 gram monofilament, and (3) nephropathy based on estimated glomerular filtration rate (eGFR by chronic kidney disease (CKD-Epi) equation ) (<45 ml/min, confirmed) and albumin-to-creatinine ratio in spot urine (> 30mg/gm, confirmed). (NCT00038727)
Timeframe: Outcomes were assessed from 2012-2013 (approximately 2 years).
| Intervention | average percentage of participants (Number) |
|---|---|
| 1 Original Lifestyle | 11.3 |
| 2 Original Metformin | 13 |
| 3 Original Placebo | 12.4 |
Measured using coronary artery calcification (CAC). (NCT00038727)
Timeframe: Outcomes were assessed from 2012-2013 (approximately 2 years).
| Intervention | CAC geometric mean in AU (Geometric Mean) | |
|---|---|---|
| Men | Women | |
| 1 Original Lifestyle | 70.1 | 6.0 |
| 2 Original Metformin | 40.2 | 6.1 |
| 3 Original Placebo | 63.7 | 5.3 |
3 reviews available for metformin and Alcohol Drinking
| Article | Year |
|---|---|
Hepatocellular carcinoma.
Topics: Aflatoxin B1; Alcohol Drinking; Carcinoma, Hepatocellular; Fibrosis; Hepatitis B; Hepatitis B Vaccin | 2016 |
[Progress in the prevention of type 2 diabetes].
Topics: Acarbose; Adult; Alcohol Drinking; Angiotensin-Converting Enzyme Inhibitors; Blood Glucose; Chromans | 2003 |
Lifestyle choices, diet, and insulin sensitizers in polycystic ovary syndrome.
Topics: Age Factors; Alcohol Drinking; Body Weight; Caffeine; Female; Humans; Hypoglycemic Agents; Infertili | 2006 |
Lifestyle choices, diet, and insulin sensitizers in polycystic ovary syndrome.
Topics: Age Factors; Alcohol Drinking; Body Weight; Caffeine; Female; Humans; Hypoglycemic Agents; Infertili | 2006 |
Lifestyle choices, diet, and insulin sensitizers in polycystic ovary syndrome.
Topics: Age Factors; Alcohol Drinking; Body Weight; Caffeine; Female; Humans; Hypoglycemic Agents; Infertili | 2006 |
Lifestyle choices, diet, and insulin sensitizers in polycystic ovary syndrome.
Topics: Age Factors; Alcohol Drinking; Body Weight; Caffeine; Female; Humans; Hypoglycemic Agents; Infertili | 2006 |
1 trial available for metformin and Alcohol Drinking
| Article | Year |
|---|---|
Alcohol consumption and diabetes risk in the Diabetes Prevention Program.
Topics: Adult; Aged; Aged, 80 and over; Alcohol Drinking; Cholesterol, HDL; Diabetes Mellitus, Type 2; Energ | 2009 |
7 other studies available for metformin and Alcohol Drinking
| Article | Year |
|---|---|
Laboratory-Confirmed Metformin-Associated Lactic Acidosis
Topics: Acidosis, Lactic; Aged; Alcohol Drinking; Continuous Renal Replacement Therapy; Diabetes Mellitus, T | 2019 |
Association between metformin dose and vitamin B12 deficiency in patients with type 2 diabetes.
Topics: Age Factors; Aged; Alcohol Drinking; Anemia; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Dos | 2019 |
Metformin improved memory impairment caused by chronic ethanol consumption during adolescent to adult period of rats: Role of oxidative stress and neuroinflammation.
Topics: Age Factors; Alcohol Drinking; Animals; Brain; Ethanol; Hippocampus; Male; Memory; Memory Disorders; | 2021 |
Hippocampus-dependent memory and allele-specific gene expression in adult offspring of alcohol-consuming dams after neonatal treatment with thyroxin or metformin.
Topics: Alcohol Drinking; Alleles; Animals; Ethanol; Fear; Female; Fetal Alcohol Spectrum Disorders; Hippoca | 2018 |
Increased Serum Insulin Exposure Does Not Affect Age or Stage of Pancreatic Adenocarcinoma Diagnosis in Patients With Diabetes Mellitus.
Topics: Adenocarcinoma; Age of Onset; Aged; Alcohol Drinking; Body Mass Index; Cohort Studies; Diabetes Mell | 2016 |
Lactic acidosis in patients with diabetes.
Topics: Acidosis, Lactic; Adult; Aged; Aged, 80 and over; Alcohol Drinking; Alcoholism; Diabetes Mellitus, T | 2013 |
Plasma homocysteine levels in patients with type 2 diabetes in a Mediterranean population: relation with nutritional and other factors.
Topics: Adult; Aged; Alcohol Drinking; Animals; Blood Glucose; Blood Pressure; Coffee; Diabetes Mellitus, Ty | 2005 |