metformin has been researched along with Age-Related Memory Disorders in 24 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The mice fed with HFD were dosed with metformin (200 mg/kg) or thymol (20, 40 mg/kg) daily." | 5.46 | Thymol improves high-fat diet-induced cognitive deficits in mice via ameliorating brain insulin resistance and upregulating NRF2/HO-1 pathway. ( Li, H; Li, M; Ma, S; Qin, T, 2017) |
| "Metformin was injected intraperitoneally in dose of 200mg/kg along with alternate-day PTZ." | 5.40 | Metformin protects against seizures, learning and memory impairments and oxidative damage induced by pentylenetetrazole-induced kindling in mice. ( Liu, LM; Wang, WP; Xu, F; Xu, XC; Zhang, WL; Zhao, RR, 2014) |
| "Sixty-two obese patients in treatment with metformin-with prediabetes (n = 41) or newly diagnosed T2DM (n = 21), were studied." | 4.02 | Insulin resistance and NAFLD may influence memory performance in obese patients with prediabetes or newly-diagnosed type 2 diabetes. ( Ciotti, S; Cipollone, F; Consoli, A; Desideri, G; Di Castelnuovo, A; Guagnano, MT; Liani, R; Santilli, F; Simeone, PG; Tartaro, A; Tripaldi, R; Vadini, F, 2021) |
| " However, long-term use of metformin may lead to side-effects such as memory impairment." | 2.72 | Potential mechanisms of metformin-induced memory impairment. ( Alhowail, A, 2021) |
| "Metformin was administrated through drinking water for four months, and we observed tau spreading in the brain of tau-seeded PS19 mice." | 1.91 | Metformin Attenuates Tau Pathology in Tau-Seeded PS19 Mice. ( Chen, Y; Fan, Z; Li, K; Li, Z; Liu, Z; Pu, J; Shen, T; Tian, J; Yan, Y; Yuan, Y; Zhang, B; Zhang, X; Zhao, S, 2023) |
| " This study aimed to evaluate the effects of long-term administration of metformin on age-dependent oxidative stress and cognitive function." | 1.62 | Long-term administration of metformin ameliorates age-dependent oxidative stress and cognitive function in rats. ( Baharvand, F; Gorgich, EAC; Parsaie, H; Sarbishegi, M; Yarmand, S, 2021) |
| "Metformin is a primary treatment for type 2 diabetes mellitus that can pass through the blood-brain barrier." | 1.56 | Metformin alleviates memory and hippocampal neurogenesis decline induced by methotrexate chemotherapy in a rat model. ( Chaisawang, P; Pannangrong, W; Prajit, R; Sirichoat, A; Sritawan, N; Welbat, JU; Wigmore, P, 2020) |
| "Thus, to understand the cognitive impairments caused by this chemotherapeutic agent, a clinically relevant dose to cancer treatment was used in mice to establish the chemobrain models, and the spatial memory of these mice was assessed using multiple behavior tests." | 1.51 | Ameliorative effect of metformin on cyclophosphamide-induced memory impairment in mice. ( Alhowail, AH; Chigurupati, S; Mani, V; Sajid, S, 2019) |
| "Hippocampus-based learning and memory deficits are key symptoms of FASD." | 1.48 | Hippocampus-dependent memory and allele-specific gene expression in adult offspring of alcohol-consuming dams after neonatal treatment with thyroxin or metformin. ( Ferreira, A; Lim, PH; Redei, EE; Tunc-Ozcan, E; Wert, SL, 2018) |
| "Metformin has been reported to have anti-inflammatory efficacy." | 1.48 | Metformin treatment prevents amyloid plaque deposition and memory impairment in APP/PS1 mice. ( Gong, Z; He, X; Huang, J; Kong, X; Li, J; Li, Q; Long, D; Ou, Z; Sun, X; Xu, B; Xu, L; Xuan, A; Zhang, L, 2018) |
| " The mice fed with HFD were dosed with metformin (200 mg/kg) or thymol (20, 40 mg/kg) daily." | 1.46 | Thymol improves high-fat diet-induced cognitive deficits in mice via ameliorating brain insulin resistance and upregulating NRF2/HO-1 pathway. ( Li, H; Li, M; Ma, S; Qin, T, 2017) |
| "Metabolic dysfunction exacerbates Alzheimer's disease (AD) incidence and progression." | 1.42 | Metformin treatment alters memory function in a mouse model of Alzheimer's disease. ( DiTacchio, KA; Dziewczapolski, G; Heinemann, SF, 2015) |
| "Metformin was injected intraperitoneally in dose of 200mg/kg along with alternate-day PTZ." | 1.40 | Metformin protects against seizures, learning and memory impairments and oxidative damage induced by pentylenetetrazole-induced kindling in mice. ( Liu, LM; Wang, WP; Xu, F; Xu, XC; Zhang, WL; Zhao, RR, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 12 (50.00) | 24.3611 |
| 2020's | 12 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sritawan, N | 2 |
| Suwannakot, K | 1 |
| Naewla, S | 1 |
| Chaisawang, P | 2 |
| Aranarochana, A | 1 |
| Sirichoat, A | 2 |
| Pannangrong, W | 2 |
| Wigmore, P | 2 |
| Welbat, JU | 2 |
| Sanati, M | 1 |
| Aminyavari, S | 1 |
| Afshari, AR | 1 |
| Sahebkar, A | 1 |
| Zhao, S | 3 |
| Fan, Z | 3 |
| Zhang, X | 3 |
| Li, Z | 3 |
| Shen, T | 3 |
| Li, K | 3 |
| Yan, Y | 3 |
| Yuan, Y | 3 |
| Pu, J | 3 |
| Tian, J | 3 |
| Liu, Z | 3 |
| Chen, Y | 3 |
| Zhang, B | 3 |
| Shabab, S | 1 |
| Mahmoudabady, M | 1 |
| Hosseini, M | 2 |
| Gholamnezhad, Z | 1 |
| Fouladi, M | 1 |
| Asghari, AA | 1 |
| Ponce-Lopez, T | 1 |
| González Álvarez Tostado, JA | 1 |
| Dias, F | 1 |
| Montiel Maltez, KH | 1 |
| Alhowail, AH | 1 |
| Chigurupati, S | 1 |
| Sajid, S | 1 |
| Mani, V | 1 |
| Li, J | 2 |
| Jiang, Y | 1 |
| Xu, T | 1 |
| Zhang, Y | 1 |
| Xue, J | 1 |
| Gao, X | 1 |
| Yang, X | 1 |
| Wang, X | 1 |
| Jia, X | 1 |
| Cheng, W | 1 |
| Jin, S | 1 |
| Saffari, PM | 1 |
| Alijanpour, S | 1 |
| Takzaree, N | 1 |
| Sahebgharani, M | 1 |
| Etemad-Moghadam, S | 1 |
| Noorbakhsh, F | 1 |
| Partoazar, A | 1 |
| Prajit, R | 1 |
| Gorgich, EAC | 1 |
| Parsaie, H | 1 |
| Yarmand, S | 1 |
| Baharvand, F | 1 |
| Sarbishegi, M | 1 |
| Baradaran, Z | 1 |
| Vakilian, A | 1 |
| Zare, M | 1 |
| Hashemzehi, M | 1 |
| Dinpanah, H | 1 |
| Beheshti, F | 1 |
| Vadini, F | 1 |
| Simeone, PG | 1 |
| Desideri, G | 1 |
| Liani, R | 1 |
| Tripaldi, R | 1 |
| Ciotti, S | 1 |
| Tartaro, A | 1 |
| Guagnano, MT | 1 |
| Di Castelnuovo, A | 1 |
| Cipollone, F | 1 |
| Consoli, A | 1 |
| Santilli, F | 1 |
| Alhowail, A | 1 |
| Areosa Sastre, A | 1 |
| Vernooij, RW | 1 |
| González-Colaço Harmand, M | 1 |
| Martínez, G | 1 |
| Tunc-Ozcan, E | 1 |
| Wert, SL | 1 |
| Lim, PH | 1 |
| Ferreira, A | 1 |
| Redei, EE | 1 |
| Ou, Z | 1 |
| Kong, X | 1 |
| Sun, X | 1 |
| He, X | 1 |
| Zhang, L | 1 |
| Gong, Z | 1 |
| Huang, J | 1 |
| Xu, B | 1 |
| Long, D | 1 |
| Li, Q | 1 |
| Xu, L | 1 |
| Xuan, A | 1 |
| Delkhosh-Kasmaie, F | 1 |
| Farshid, AA | 1 |
| Tamaddonfard, E | 1 |
| Imani, M | 1 |
| Zhao, M | 1 |
| Cheng, X | 1 |
| Lin, X | 1 |
| Han, Y | 1 |
| Zhou, Y | 1 |
| Zhao, T | 1 |
| He, Y | 1 |
| Wu, L | 1 |
| Zhao, Y | 1 |
| Fan, M | 1 |
| Zhu, L | 1 |
| Zhao, RR | 1 |
| Xu, XC | 1 |
| Xu, F | 1 |
| Zhang, WL | 2 |
| Liu, LM | 1 |
| Wang, WP | 1 |
| DiTacchio, KA | 1 |
| Heinemann, SF | 1 |
| Dziewczapolski, G | 1 |
| Mostafa, DK | 1 |
| Ismail, CA | 1 |
| Ghareeb, DA | 1 |
| Hill, JL | 1 |
| Kobori, N | 1 |
| Zhao, J | 1 |
| Rozas, NS | 1 |
| Hylin, MJ | 1 |
| Moore, AN | 1 |
| Dash, PK | 1 |
| Li, H | 1 |
| Qin, T | 1 |
| Li, M | 1 |
| Ma, S | 1 |
| Bhutada, P | 1 |
| Mundhada, Y | 1 |
| Bansod, K | 1 |
| Tawari, S | 1 |
| Patil, S | 1 |
| Dixit, P | 1 |
| Umathe, S | 1 |
| Mundhada, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Gut-Brain-axis: Targets for Improvement of Cognition in the Elderly[NCT04841668] | 136 participants (Anticipated) | Observational | 2021-04-10 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for metformin and Age-Related Memory Disorders
| Article | Year |
|---|---|
Mechanistic insight into the role of metformin in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cognition; Disease Models, Animal; Hippoca | 2022 |
Potential mechanisms of metformin-induced memory impairment.
Topics: Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Memory Disorders; Metformin | 2021 |
Effect of the treatment of Type 2 diabetes mellitus on the development of cognitive impairment and dementia.
Topics: Carbamates; Cause of Death; Cognition Disorders; Diabetes Mellitus, Type 2; Glyburide; Humans; Hypog | 2017 |
21 other studies available for metformin and Age-Related Memory Disorders
| Article | Year |
|---|---|
Effect of metformin treatment on memory and hippocampal neurogenesis decline correlated with oxidative stress induced by methotrexate in rats.
Topics: Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Doublecortin P | 2021 |
Metformin Attenuates Tau Pathology in Tau-Seeded PS19 Mice.
Topics: Alzheimer Disease; Animals; Brain; Disease Models, Animal; Memory Disorders; Metformin; Mice; Mice, | 2023 |
Metformin Attenuates Tau Pathology in Tau-Seeded PS19 Mice.
Topics: Alzheimer Disease; Animals; Brain; Disease Models, Animal; Memory Disorders; Metformin; Mice; Mice, | 2023 |
Metformin Attenuates Tau Pathology in Tau-Seeded PS19 Mice.
Topics: Alzheimer Disease; Animals; Brain; Disease Models, Animal; Memory Disorders; Metformin; Mice; Mice, | 2023 |
Metformin Attenuates Tau Pathology in Tau-Seeded PS19 Mice.
Topics: Alzheimer Disease; Animals; Brain; Disease Models, Animal; Memory Disorders; Metformin; Mice; Mice, | 2023 |
Metformin Attenuates Tau Pathology in Tau-Seeded PS19 Mice.
Topics: Alzheimer Disease; Animals; Brain; Disease Models, Animal; Memory Disorders; Metformin; Mice; Mice, | 2023 |
Metformin Attenuates Tau Pathology in Tau-Seeded PS19 Mice.
Topics: Alzheimer Disease; Animals; Brain; Disease Models, Animal; Memory Disorders; Metformin; Mice; Mice, | 2023 |
Metformin Attenuates Tau Pathology in Tau-Seeded PS19 Mice.
Topics: Alzheimer Disease; Animals; Brain; Disease Models, Animal; Memory Disorders; Metformin; Mice; Mice, | 2023 |
Metformin Attenuates Tau Pathology in Tau-Seeded PS19 Mice.
Topics: Alzheimer Disease; Animals; Brain; Disease Models, Animal; Memory Disorders; Metformin; Mice; Mice, | 2023 |
Metformin Attenuates Tau Pathology in Tau-Seeded PS19 Mice.
Topics: Alzheimer Disease; Animals; Brain; Disease Models, Animal; Memory Disorders; Metformin; Mice; Mice, | 2023 |
The effects of endurance exercise and metformin on memory impairment caused by diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Exercise Therapy; Glucose; Humans; Male; Memory Disorders; | 2023 |
Metformin Prevents NDEA-Induced Memory Impairments Associated with Attenuating Beta-Amyloid, Tumor Necrosis Factor-Alpha, and Interleukin-6 Levels in the Hippocampus of Rats.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Carcinogens; Cytokines; Diethylnitrosamine; Hippo | 2023 |
Ameliorative effect of metformin on cyclophosphamide-induced memory impairment in mice.
Topics: Animals; Cognitive Dysfunction; Cyclophosphamide; Disease Models, Animal; Dose-Response Relationship | 2019 |
Wilson Disease With Novel Compound Heterozygote Mutations in the
Topics: Chelating Agents; Chelation Therapy; China; Copper; Copper-Transporting ATPases; Diabetes Mellitus; | 2020 |
Metformin loaded phosphatidylserine nanoliposomes improve memory deficit and reduce neuroinflammation in streptozotocin-induced Alzheimer's disease model.
Topics: Alzheimer Disease; Animals; Cytokines; Disease Models, Animal; Hippocampus; Inflammation; Liposomes; | 2020 |
Metformin alleviates memory and hippocampal neurogenesis decline induced by methotrexate chemotherapy in a rat model.
Topics: Animals; Antimetabolites, Antineoplastic; Disease Models, Animal; Doublecortin Protein; Hippocampus; | 2020 |
Long-term administration of metformin ameliorates age-dependent oxidative stress and cognitive function in rats.
Topics: Aging; Animals; Antioxidants; CA1 Region, Hippocampal; Cognitive Dysfunction; Male; Memory Disorders | 2021 |
Metformin improved memory impairment caused by chronic ethanol consumption during adolescent to adult period of rats: Role of oxidative stress and neuroinflammation.
Topics: Age Factors; Alcohol Drinking; Animals; Brain; Ethanol; Hippocampus; Male; Memory; Memory Disorders; | 2021 |
Insulin resistance and NAFLD may influence memory performance in obese patients with prediabetes or newly-diagnosed type 2 diabetes.
Topics: Age Factors; Blood Glucose; Cognition; Cognitive Dysfunction; Diabetes Mellitus, Type 2; Female; Hum | 2021 |
Hippocampus-dependent memory and allele-specific gene expression in adult offspring of alcohol-consuming dams after neonatal treatment with thyroxin or metformin.
Topics: Alcohol Drinking; Alleles; Animals; Ethanol; Fear; Female; Fetal Alcohol Spectrum Disorders; Hippoca | 2018 |
Metformin treatment prevents amyloid plaque deposition and memory impairment in APP/PS1 mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Hippocampus; Male | 2018 |
The effects of safranal, a constitute of saffron, and metformin on spatial learning and memory impairments in type-1 diabetic rats: behavioral and hippocampal histopathological and biochemical evaluations.
Topics: Animals; Behavior, Animal; Caspase 3; Cell Count; Crocus; Cyclohexenes; Diabetes Mellitus, Experimen | 2018 |
Metformin administration prevents memory impairment induced by hypobaric hypoxia in rats.
Topics: Animals; Apoptosis; Cognition; Hippocampus; Hypoxia; Male; Maze Learning; Memory Disorders; Metformi | 2019 |
Metformin protects against seizures, learning and memory impairments and oxidative damage induced by pentylenetetrazole-induced kindling in mice.
Topics: Animals; Antioxidants; Brain; Convulsants; Glutathione; Kindling, Neurologic; Learning Disabilities; | 2014 |
Metformin treatment alters memory function in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Blood Glucose; Dis | 2015 |
Differential metformin dose-dependent effects on cognition in rats: role of Akt.
Topics: Alzheimer Disease; Analysis of Variance; Animals; Behavior, Animal; Cholinergic Antagonists; Cogniti | 2016 |
Traumatic brain injury decreases AMP-activated protein kinase activity and pharmacological enhancement of its activity improves cognitive outcome.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Brain Injuries, Traumatic; Enzym | 2016 |
Thymol improves high-fat diet-induced cognitive deficits in mice via ameliorating brain insulin resistance and upregulating NRF2/HO-1 pathway.
Topics: Animals; Antioxidants; Cognition Disorders; Cytokines; Diet, High-Fat; Heme Oxygenase-1; Hypoglycemi | 2017 |
Protection of cholinergic and antioxidant system contributes to the effect of berberine ameliorating memory dysfunction in rat model of streptozotocin-induced diabetes.
Topics: Acetylcholine; Administration, Oral; Analysis of Variance; Animals; Antioxidants; Ascorbic Acid; Ber | 2011 |