metformin has been researched along with Adult Periodontitis in 14 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the effect of metformin combined with DPP-4 inhibitor on alveolar bone density in patients with type 2 diabetes mellitus and chronic periodontitis." | 1.91 | [Effect of metformin combined with DPP-4 inhibitor on alveolar bone density in patients with type 2 diabetes mellitus and chronic periodontitis]. ( Ahemaiti, A; Gulinuer, A; Liu, K; Tuernisaguli, K, 2023) |
| "Metformin treatment could partly restore the abundance of several genera in CP-DM, such as Acholeplasma and Comamonas." | 1.62 | Effects of type 2 diabetes and metformin on salivary microbiota in patients with chronic periodontitis. ( Gu, M; Hu, N; Jiang, Z; Jin, C; Wang, P; Xiang, S; Xu, D, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 12 (85.71) | 24.3611 |
| 2020's | 2 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Gu, M | 1 |
| Wang, P | 1 |
| Xiang, S | 1 |
| Xu, D | 1 |
| Jin, C | 1 |
| Jiang, Z | 1 |
| Hu, N | 1 |
| Liu, K | 1 |
| Ahemaiti, A | 1 |
| Tuernisaguli, K | 1 |
| Gulinuer, A | 1 |
| Zúñiga Curz, CA | 1 |
| Calzada Mendoza, CC | 1 |
| Miranda Mondragón, ID | 1 |
| Bustamante Bacame, A | 1 |
| Portilla Robertson, J | 1 |
| Ocharán Hernández, E | 1 |
| Pradeep, AR | 7 |
| Patnaik, K | 3 |
| Nagpal, K | 3 |
| Karvekar, S | 3 |
| Guruprasad, CN | 2 |
| Kumaraswamy, KM | 1 |
| Pankaj, D | 1 |
| Sahu, I | 1 |
| Kurian, IG | 2 |
| Akram, Z | 1 |
| Vohra, F | 1 |
| Javed, F | 1 |
| Dileep, P | 1 |
| Ipshita, S | 1 |
| Nicolini, AC | 1 |
| Grisa, TA | 1 |
| Muniz, FWMG | 1 |
| Rösing, CK | 1 |
| Cavagni, J | 1 |
| Naik, SB | 4 |
| Ramamurthy, BL | 1 |
| Suke, D | 1 |
| Singh, P | 1 |
| Raju, A | 1 |
| Malhotra, A | 1 |
| Han, B | 1 |
| You, L | 1 |
| Rao, NS | 2 |
| Kumari, M | 2 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Local Drug Delivery of 1% Metformin Gel in Moderate and Severe Periodontitis Subjects: a Randomized Controlled Clinical Trial[NCT02274090] | Phase 2/Phase 3 | 70 participants (Actual) | Interventional | 2013-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for metformin and Adult Periodontitis
| Article | Year |
|---|---|
Locally delivered metformin as adjunct to scaling and root planing in the treatment of periodontal defects: A systematic review and meta-analysis.
Topics: Chronic Periodontitis; Databases, Bibliographic; Dental Scaling; Humans; Metformin; Randomized Contr | 2018 |
Effect of adjuvant use of metformin on periodontal treatment: a systematic review and meta-analysis.
Topics: Chronic Periodontitis; Dental Scaling; Humans; Metformin; Randomized Controlled Trials as Topic | 2019 |
6 trials available for metformin and Adult Periodontitis
| Article | Year |
|---|---|
Efficacy of 1% Metformin Gel in Patients With Moderate and Severe Chronic Periodontitis: A Randomized Controlled Clinical Trial.
Topics: Adult; Chronic Periodontitis; Combined Modality Therapy; Dental Scaling; Double-Blind Method; Female | 2017 |
Comparative evaluation of subgingivally delivered 1.2% rosuvastatin and 1% metformin gel in treatment of intrabony defects in chronic periodontitis: A randomized controlled clinical trial.
Topics: Chronic Periodontitis; Combined Modality Therapy; Dental Scaling; Humans; Metformin; Periodontal Ind | 2018 |
Platelet-rich fibrin with 1% metformin for the treatment of intrabony defects in chronic periodontitis: a randomized controlled clinical trial.
Topics: Adult; Alveolar Bone Loss; Blood Platelets; Chronic Periodontitis; Debridement; Dental Plaque Index; | 2015 |
Efficacy of locally-delivered 1% metformin gel in the treatment of intrabony defects in patients with chronic periodontitis: a randomized, controlled clinical trial.
Topics: Adult; Alveolar Bone Loss; Chronic Periodontitis; Combined Modality Therapy; Dental Scaling; Female; | 2016 |
Efficacy of varying concentrations of subgingivally delivered metformin in the treatment of chronic periodontitis: a randomized controlled clinical trial.
Topics: Administration, Topical; Adult; Alveolar Bone Loss; Chromatography, High Pressure Liquid; Chronic Pe | 2013 |
Locally delivered 1% metformin gel in the treatment of smokers with chronic periodontitis: a randomized controlled clinical trial.
Topics: Administration, Topical; Adult; Alveolar Bone Loss; Bone Density Conservation Agents; Chronic Period | 2013 |
6 other studies available for metformin and Adult Periodontitis
| Article | Year |
|---|---|
Effects of type 2 diabetes and metformin on salivary microbiota in patients with chronic periodontitis.
Topics: Chronic Periodontitis; Diabetes Mellitus, Type 2; Humans; Metformin; Microbiota; RNA, Ribosomal, 16S | 2021 |
[Effect of metformin combined with DPP-4 inhibitor on alveolar bone density in patients with type 2 diabetes mellitus and chronic periodontitis].
Topics: Adiponectin; Bone Density; C-Reactive Protein; Chronic Periodontitis; Diabetes Mellitus, Type 2; Dip | 2023 |
[Effect of the management of class I obesity with metformin on metalloproteinase activity in patients with chronic periodontitis].
Topics: Adult; Chronic Periodontitis; Female; Humans; Hypoglycemic Agents; Metalloproteases; Metformin; Obes | 2019 |
Comparative evaluation of subgingivally-delivered 1% metformin and Aloe vera gel in the treatment of intrabony defects in chronic periodontitis patients: A randomized, controlled clinical trial.
Topics: Adult; Alveolar Bone Loss; Chronic Periodontitis; Combined Modality Therapy; Dental Scaling; Female; | 2018 |
Letters to the Editor: Re: Platelet-Rich Fibrin With 1% Metformin for the Treatment of Intrabony Defects in Chronic Periodontitis: A Randomized Controlled Clinical Trial.
Topics: Alveolar Bone Loss; Chronic Periodontitis; Fibrin; Humans; Metformin; Periodontal Attachment Loss; P | 2016 |
[Effect of initial periodontal therapy on diabetic patients with chronic periodontitis].
Topics: Adult; Alveolar Bone Loss; Blood Glucose; Chronic Periodontitis; Dental Scaling; Diabetes Mellitus, | 2010 |