metformin has been researched along with Adjuvant Arthritis in 9 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Metformin is used for the treatment of type 2 diabetes and was reported to exert therapeutic effects against rheumatoid arthritis and obesity by improving mitochondrial dysfunction via the activation of fibroblast growth factor 21." | 7.96 | Metformin rescues rapamycin-induced mitochondrial dysfunction and attenuates rheumatoid arthritis with metabolic syndrome. ( Cho, ML; Choi, JW; Jung, KA; Kim, DS; Kim, EK; Lee, SY; Min, HK; Na, HS; Park, SH; Ryu, JG, 2020) |
| " Metformin has been reported to have a therapeutic effect on RA and obesity." | 7.88 | Metformin ameliorates experimental-obesity-associated autoimmune arthritis by inducing FGF21 expression and brown adipocyte differentiation. ( Cho, ML; Choi, JY; Jhun, JY; Kim, EK; Kim, JK; Kim, SY; Lee, SH; Lee, SY; Na, HS; Park, SH; Yang, CW, 2018) |
| "Metformin was administered orally every day to rats with OA." | 5.62 | Metformin Attenuates Monosodium-Iodoacetate-Induced Osteoarthritis via Regulation of Pain Mediators and the Autophagy-Lysosomal Pathway. ( Cho, KH; Cho, ML; Choi, JW; Jung, K; Kim, SJ; Kwon, JY; Lee, AR; Lee, DH; Lee, SH; Lee, SY; Min, HK; Na, HS; Park, SH; Woo, JS, 2021) |
| " Metformin is used for the treatment of type 2 diabetes and was reported to exert therapeutic effects against rheumatoid arthritis and obesity by improving mitochondrial dysfunction via the activation of fibroblast growth factor 21." | 3.96 | Metformin rescues rapamycin-induced mitochondrial dysfunction and attenuates rheumatoid arthritis with metabolic syndrome. ( Cho, ML; Choi, JW; Jung, KA; Kim, DS; Kim, EK; Lee, SY; Min, HK; Na, HS; Park, SH; Ryu, JG, 2020) |
| " Metformin has been reported to have a therapeutic effect on RA and obesity." | 3.88 | Metformin ameliorates experimental-obesity-associated autoimmune arthritis by inducing FGF21 expression and brown adipocyte differentiation. ( Cho, ML; Choi, JY; Jhun, JY; Kim, EK; Kim, JK; Kim, SY; Lee, SH; Lee, SY; Na, HS; Park, SH; Yang, CW, 2018) |
| " The results indicated that the bioavailability of metformin was markedly decreased in the CIA rats." | 1.62 | Pharmacokinetics of metformin in collagen-induced arthritis rats. ( Chen, M; Hu, W; Liu, S; Xie, C; Yang, R; Ye, L; You, G; Zheng, Z, 2021) |
| "Metformin was administered orally every day to rats with OA." | 1.62 | Metformin Attenuates Monosodium-Iodoacetate-Induced Osteoarthritis via Regulation of Pain Mediators and the Autophagy-Lysosomal Pathway. ( Cho, KH; Cho, ML; Choi, JW; Jung, K; Kim, SJ; Kwon, JY; Lee, AR; Lee, DH; Lee, SH; Lee, SY; Min, HK; Na, HS; Park, SH; Woo, JS, 2021) |
| "Metformin treatment of normal cells cultured in Th17-differentiation-inducing conditions decreased the number of RORĪ³t-expressing CD4+ cells in a dose-dependent manner and downregulated STAT3 phosphorylation via the AMPK pathway." | 1.39 | Metformin downregulates Th17 cells differentiation and attenuates murine autoimmune arthritis. ( Cho, JH; Ju, JH; Jung, HR; Kang, KY; Kim, HY; Kim, IJ; Kim, J; Kim, YK; Park, SH; Yi, H, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 5 (55.56) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, EK | 4 |
| Min, HK | 2 |
| Lee, SY | 4 |
| Kim, DS | 1 |
| Ryu, JG | 1 |
| Na, HS | 4 |
| Jung, KA | 1 |
| Choi, JW | 2 |
| Park, SH | 6 |
| Cho, ML | 5 |
| Park, YH | 1 |
| Jang, YJ | 1 |
| Choi, Y | 1 |
| Lee, K | 1 |
| Kim, HJ | 1 |
| Cho, O | 1 |
| Lee, HR | 1 |
| Heo, TH | 1 |
| Chen, M | 1 |
| You, G | 1 |
| Xie, C | 1 |
| Yang, R | 1 |
| Hu, W | 1 |
| Zheng, Z | 1 |
| Liu, S | 1 |
| Ye, L | 1 |
| El-Sayyad, SM | 1 |
| Ali, MA | 1 |
| Kandil, LS | 1 |
| Ragab, GM | 1 |
| Abdelhamid Ibrahim, SS | 1 |
| Kwon, JY | 1 |
| Lee, SH | 2 |
| Lee, AR | 1 |
| Woo, JS | 1 |
| Jung, K | 1 |
| Cho, KH | 1 |
| Lee, DH | 1 |
| Kim, SJ | 1 |
| Kim, JK | 2 |
| Jhun, JY | 1 |
| Kim, SY | 2 |
| Choi, JY | 1 |
| Yang, CW | 1 |
| Kang, KY | 1 |
| Kim, YK | 1 |
| Yi, H | 1 |
| Kim, J | 1 |
| Jung, HR | 1 |
| Kim, IJ | 1 |
| Cho, JH | 1 |
| Kim, HY | 1 |
| Ju, JH | 1 |
| Son, HJ | 1 |
| Lee, J | 1 |
| Park, MJ | 1 |
| Kim, KW | 1 |
| Jhun, J | 1 |
| Lee, S | 1 |
| Jeong, JH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Coenzyme Q10 Supplementation on the Clinical Outcome of Juvenile Idiopathic Arthritis Patients[NCT05871086] | Phase 2/Phase 3 | 60 participants (Anticipated) | Interventional | 2023-05-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 other studies available for metformin and Adjuvant Arthritis
| Article | Year |
|---|---|
Metformin rescues rapamycin-induced mitochondrial dysfunction and attenuates rheumatoid arthritis with metabolic syndrome.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Drug Therapy, Combination; Hypoglycemic Age | 2020 |
Combination of LMT-28 and Metformin Improves Beneficial Anti-Inflammatory Effect in Collagen-Induced Arthritis.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Cell Differentiation; Cell Line; Collage | 2021 |
Pharmacokinetics of metformin in collagen-induced arthritis rats.
Topics: Animals; Arthritis, Experimental; Blood Glucose; Female; Hypoglycemic Agents; Metformin; Rats; Rats, | 2021 |
Metformin and omega-3 fish oil elicit anti-inflammatory effects via modulation of some dysregulated micro RNAs expression and signaling pathways in experimental induced arthritis.
Topics: Animals; Anti-Inflammatory Agents; Antimetabolites, Antineoplastic; Arthritis, Experimental; Disease | 2021 |
Metformin Attenuates Monosodium-Iodoacetate-Induced Osteoarthritis via Regulation of Pain Mediators and the Autophagy-Lysosomal Pathway.
Topics: Animals; Arthritis, Experimental; Celecoxib; Chondrocytes; Diabetes Mellitus, Type 2; Disease Models | 2021 |
Metformin ameliorates experimental-obesity-associated autoimmune arthritis by inducing FGF21 expression and brown adipocyte differentiation.
Topics: Adipocytes, Brown; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Arthri | 2018 |
Metformin downregulates Th17 cells differentiation and attenuates murine autoimmune arthritis.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Cell Differentiation; Cytokines; Male; M | 2013 |
Metformin attenuates experimental autoimmune arthritis through reciprocal regulation of Th17/Treg balance and osteoclastogenesis.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Cell Differentiation; Interleukin-17; Male; | 2014 |
Combination therapy with metformin and coenzyme Q10 in murine experimental autoimmune arthritis.
Topics: Animals; Arthritis, Experimental; Cell Differentiation; Cytokines; Drug Therapy, Combination; Gene E | 2016 |