Page last updated: 2024-10-30

metformin and Adenoma

metformin has been researched along with Adenoma in 25 studies

Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.

Adenoma: A benign epithelial tumor with a glandular organization.

Research Excerpts

ExcerptRelevanceReference
" Metformin use was negatively associated with the incidence of colorectal adenoma (RR: 0."9.05Suppressive effects of metformin on colorectal adenoma incidence and malignant progression. ( Deng, M; Huang, D; Lei, S; Wang, H; Wu, Y; Xia, S; Xu, E; Zhang, H, 2020)
"This meta-analysis showed that metformin use significantly reduces colorectal adenoma and cancer incidence and improves colorectal cancer outcomes."9.05Metformin and colorectal cancer: a systematic review, meta-analysis and meta-regression. ( Chong, CS; Jiang, AA; Khoo, CM; Ng, CH; Ng, CW; Ong, ZH; Peng, S; Sundar, R; Tham, HY; Toh, EMS, 2020)
"Although it is known that metformin can reduce risk of colorectal cancer, it is unclear whether it protects against colorectal adenoma."8.95Metformin use and the risk of colorectal adenoma: A systematic review and meta-analysis. ( Eun, CS; Han, DS; Jung, YS; Park, CH; Park, DI, 2017)
"Existing data evaluating the impact of metformin on the colorectal adenoma (CRA) risk in patients suffering from type 2 diabetes (T2D) are limited and controversial."8.95Metformin therapy and the risk of colorectal adenoma in patients with type 2 diabetes: A meta-analysis. ( Fang, JY; Hou, YC; Hu, Q; Huang, J; Xiong, H, 2017)
"Recent evidence indicates that metformin therapy may be associated with a decreased colorectal adenoma/colorectal cancer risk in type 2 diabetes patients."8.95Metformin therapy and risk of colorectal adenomas and colorectal cancer in type 2 diabetes mellitus patients: A systematic review and meta-analysis. ( Chu, Y; Li, X; Liu, F; Liu, Y; Lu, Y; Nie, S; Rui, D; Wang, Z; Xiang, H; Yan, L, 2017)
"We aimed to determine the impact of metformin use on the behavior of colorectal adenomas in a US veteran population."8.12Metformin Use Is Inversely Associated with Prevalent, but Not Incident Colorectal Adenomas. ( Abrams, JA; Araujo, JL; Buitrago, C; Huang, CH; Karkenny, G; Krigel, A; Lebwohl, B; Nguyen, STT; Talukder, N, 2022)
"Existing studies suggest that metformin lowers the risk and mortality of colorectal cancer."7.85The effect of metformin on the recurrence of colorectal adenoma in diabetic patients with previous colorectal adenoma. ( Cheon, JH; Han, MS; Hong, SP; Kim, TI; Kim, WH; Lee, HJ; Park, SJ, 2017)
"Existing literature suggests that metformin, the most commonly used biguanide, may lower colorectal cancer risk."7.81Metformin use and risk of colorectal adenoma after polypectomy in patients with type 2 diabetes mellitus. ( Corley, DA; Doubeni, CA; Jensen, CD; Marks, AR; Pietrofesa, RA; Zebrowski, A, 2015)
"Among 488 consecutive diabetic patients who underwent colonoscopic surveillance after curative resection of colorectal cancer between 1998 and 2008, 240 patients were enrolled in this study and were compared in two groups: 114 patients taking metformin and 126 patients not taking metformin."7.78Metformin use is associated with a decreased incidence of colorectal adenomas in diabetic patients with previous colorectal cancer. ( Cheon, JH; Hong, SP; Jeon, SM; Kim, TI; Kim, WH; Lee, JH, 2012)
"Metformin has a potential role in the chemoprevention of colorectal cancer."6.82Metformin for chemoprevention of metachronous colorectal adenoma or polyps in post-polypectomy patients without diabetes: a multicentre double-blind, placebo-controlled, randomised phase 3 trial. ( Arimoto, J; Hata, Y; Hattori, A; Higurashi, T; Hosono, K; Inayama, Y; Kessoku, T; Komiya, Y; Matsuhashi, N; Nagase, H; Nakajima, A; Sakai, E; Taguri, M; Takahashi, H; Taniguchi, L; Uchiyama, S; Uchiyama, T; Umezawa, S; Yamanaka, S, 2016)
"Metformin is an old, inexpensive, and relatively safe anti-diabetic medication that can decrease the risk of several types of cancer in patients with diabetes."5.72The Emerging Role of Metformin in the Prevention and Treatment of Colorectal Cancer: A Game Changer for the Management of Colorectal Cancer. ( Ala, M, 2022)
"Metformin is an anti-hyperglycemic agent used to treat diabetes, and recent evidence suggests it has antitumor efficacy."5.46Metformin inhibits proliferation and growth hormone secretion of GH3 pituitary adenoma cells. ( An, J; Duan, L; He, J; Hu, J; Li, S; Pei, X; Shen, R; Yang, H; Zang, Z; Zhang, W; Zhang, Y; Zheng, X; Zhou, Z; Zhu, F, 2017)
" Metformin use was negatively associated with the incidence of colorectal adenoma (RR: 0."5.05Suppressive effects of metformin on colorectal adenoma incidence and malignant progression. ( Deng, M; Huang, D; Lei, S; Wang, H; Wu, Y; Xia, S; Xu, E; Zhang, H, 2020)
"This meta-analysis showed that metformin use significantly reduces colorectal adenoma and cancer incidence and improves colorectal cancer outcomes."5.05Metformin and colorectal cancer: a systematic review, meta-analysis and meta-regression. ( Chong, CS; Jiang, AA; Khoo, CM; Ng, CH; Ng, CW; Ong, ZH; Peng, S; Sundar, R; Tham, HY; Toh, EMS, 2020)
"Although it is known that metformin can reduce risk of colorectal cancer, it is unclear whether it protects against colorectal adenoma."4.95Metformin use and the risk of colorectal adenoma: A systematic review and meta-analysis. ( Eun, CS; Han, DS; Jung, YS; Park, CH; Park, DI, 2017)
"Existing data evaluating the impact of metformin on the colorectal adenoma (CRA) risk in patients suffering from type 2 diabetes (T2D) are limited and controversial."4.95Metformin therapy and the risk of colorectal adenoma in patients with type 2 diabetes: A meta-analysis. ( Fang, JY; Hou, YC; Hu, Q; Huang, J; Xiong, H, 2017)
"Recent evidence indicates that metformin therapy may be associated with a decreased colorectal adenoma/colorectal cancer risk in type 2 diabetes patients."4.95Metformin therapy and risk of colorectal adenomas and colorectal cancer in type 2 diabetes mellitus patients: A systematic review and meta-analysis. ( Chu, Y; Li, X; Liu, F; Liu, Y; Lu, Y; Nie, S; Rui, D; Wang, Z; Xiang, H; Yan, L, 2017)
"We aimed to determine the impact of metformin use on the behavior of colorectal adenomas in a US veteran population."4.12Metformin Use Is Inversely Associated with Prevalent, but Not Incident Colorectal Adenomas. ( Abrams, JA; Araujo, JL; Buitrago, C; Huang, CH; Karkenny, G; Krigel, A; Lebwohl, B; Nguyen, STT; Talukder, N, 2022)
"Existing studies suggest that metformin lowers the risk and mortality of colorectal cancer."3.85The effect of metformin on the recurrence of colorectal adenoma in diabetic patients with previous colorectal adenoma. ( Cheon, JH; Han, MS; Hong, SP; Kim, TI; Kim, WH; Lee, HJ; Park, SJ, 2017)
"Existing literature suggests that metformin, the most commonly used biguanide, may lower colorectal cancer risk."3.81Metformin use and risk of colorectal adenoma after polypectomy in patients with type 2 diabetes mellitus. ( Corley, DA; Doubeni, CA; Jensen, CD; Marks, AR; Pietrofesa, RA; Zebrowski, A, 2015)
"Among 488 consecutive diabetic patients who underwent colonoscopic surveillance after curative resection of colorectal cancer between 1998 and 2008, 240 patients were enrolled in this study and were compared in two groups: 114 patients taking metformin and 126 patients not taking metformin."3.78Metformin use is associated with a decreased incidence of colorectal adenomas in diabetic patients with previous colorectal cancer. ( Cheon, JH; Hong, SP; Jeon, SM; Kim, TI; Kim, WH; Lee, JH, 2012)
"85 g metformin daily for 75 days, urinary retention caused by a prostatic adenoma induced functional renal insufficiency and hyperlactacidemia, rapidly reversed with treatment."3.66[Reversible lactic acidosis in a diabetic on high dose metformin (author's transl)]. ( Beaudot, C; Brohon, J; Lavieuville, M; Merceron, RE; Noël, M; Raymond, JP, 1980)
"Metformin has a potential role in the chemoprevention of colorectal cancer."2.82Metformin for chemoprevention of metachronous colorectal adenoma or polyps in post-polypectomy patients without diabetes: a multicentre double-blind, placebo-controlled, randomised phase 3 trial. ( Arimoto, J; Hata, Y; Hattori, A; Higurashi, T; Hosono, K; Inayama, Y; Kessoku, T; Komiya, Y; Matsuhashi, N; Nagase, H; Nakajima, A; Sakai, E; Taguri, M; Takahashi, H; Taniguchi, L; Uchiyama, S; Uchiyama, T; Umezawa, S; Yamanaka, S, 2016)
"Metformin is an old, inexpensive, and relatively safe anti-diabetic medication that can decrease the risk of several types of cancer in patients with diabetes."1.72The Emerging Role of Metformin in the Prevention and Treatment of Colorectal Cancer: A Game Changer for the Management of Colorectal Cancer. ( Ala, M, 2022)
"Diabetic ketoacidosis has been described as a rare complication of acromegaly and may be observed in 1% of affected patients."1.46Rapid Onset of Diabetic Ketoacidosis After SGLT2 Inhibition in a Patient With Unrecognized Acromegaly. ( Bilz, S; Brändle, M; Fournier, JY; Quarella, M; Walser, D, 2017)
"Metformin is an anti-hyperglycemic agent used to treat diabetes, and recent evidence suggests it has antitumor efficacy."1.46Metformin inhibits proliferation and growth hormone secretion of GH3 pituitary adenoma cells. ( An, J; Duan, L; He, J; Hu, J; Li, S; Pei, X; Shen, R; Yang, H; Zang, Z; Zhang, W; Zhang, Y; Zheng, X; Zhou, Z; Zhu, F, 2017)
"Treatment with metformin alone and in combination with pioglitazone resulted in statistically significant decreases in lung adenoma formation at both early- and late-stage interventions."1.46Fixed-Dose Combinations of Pioglitazone and Metformin for Lung Cancer Prevention. ( Antonides, JD; Clapper, ML; Galbraith, AR; Haynes, AM; Miller, KA; Miller, MS; Miller, WA; O'Sullivan, MG; Ondrey, FG; Seabloom, DE; Steele, VE; Wuertz, BR, 2017)

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-19901 (4.00)18.7374
1990's0 (0.00)18.2507
2000's1 (4.00)29.6817
2010's16 (64.00)24.3611
2020's7 (28.00)2.80

Authors

AuthorsStudies
Ala, M1
Krigel, A1
Nguyen, STT1
Talukder, N1
Huang, CH1
Buitrago, C1
Karkenny, G1
Lebwohl, B1
Abrams, JA1
Araujo, JL1
Zaccari, P1
Archibugi, L1
Belfiori, G1
Nista, E1
dell'Anna, G1
Crippa, S1
Schepis, T1
Tacelli, M1
Aleotti, F1
Petrone, MC1
Mariani, A1
Costamagna, G1
Gasbarrini, A1
Larghi, A1
Falconi, M1
Arcidiacono, PG1
Capurso, G1
Elton, AC1
Cedarstrom, V1
Quraishi, A1
Wuertz, B1
Murray, K1
Markowski, TW1
Seabloom, D1
Ondrey, FG2
Luo, Z1
Wang, B1
Luo, F1
Guo, Y1
Jiang, N1
Wei, J1
Wang, X1
Tseng, Y1
Chen, J1
Zhao, B1
Liu, J1
Deng, M1
Lei, S1
Huang, D1
Wang, H1
Xia, S1
Xu, E1
Wu, Y1
Zhang, H1
Ng, CW1
Jiang, AA1
Toh, EMS1
Ng, CH1
Ong, ZH1
Peng, S1
Tham, HY1
Sundar, R1
Chong, CS1
Khoo, CM1
Quarella, M1
Walser, D1
Brändle, M1
Fournier, JY1
Bilz, S1
An, J1
Pei, X1
Zang, Z1
Zhou, Z1
Hu, J1
Zheng, X1
Zhang, Y1
He, J1
Duan, L1
Shen, R1
Zhang, W1
Zhu, F1
Li, S1
Yang, H1
Jung, YS1
Park, CH1
Eun, CS1
Park, DI1
Han, DS1
Popovich, IG1
Piskunova, TS1
Tyndyk, ML1
Anikin, IV1
Zabezhinskiĭ, MA1
Anisimov, VN1
Kuo, SF1
Chuang, WY1
Ng, S1
Chen, CH1
Chang, CN1
Chou, CH1
Weng, WC1
Yeh, CH1
Lin, JD1
Principi, M1
De Censi, A1
Gravitz, L1
Marks, AR1
Pietrofesa, RA1
Jensen, CD1
Zebrowski, A1
Corley, DA1
Doubeni, CA1
Higurashi, T1
Hosono, K2
Takahashi, H2
Komiya, Y1
Umezawa, S1
Sakai, E2
Uchiyama, T2
Taniguchi, L1
Hata, Y1
Uchiyama, S1
Hattori, A1
Nagase, H1
Kessoku, T1
Arimoto, J1
Matsuhashi, N1
Inayama, Y1
Yamanaka, S1
Taguri, M1
Nakajima, A2
Jain, D1
Chhoda, A1
Uribe, J1
Hou, YC1
Hu, Q1
Huang, J1
Fang, JY1
Xiong, H1
Liu, F1
Yan, L1
Wang, Z1
Lu, Y1
Chu, Y1
Li, X1
Liu, Y1
Rui, D1
Nie, S1
Xiang, H1
Seabloom, DE1
Galbraith, AR1
Haynes, AM1
Antonides, JD1
Wuertz, BR1
Miller, WA1
Miller, KA1
Steele, VE1
Miller, MS1
Clapper, ML1
O'Sullivan, MG1
Han, MS1
Lee, HJ1
Park, SJ1
Hong, SP2
Cheon, JH2
Kim, WH2
Kim, TI2
Endo, H1
Sugiyama, M1
Suzuki, K1
Iida, H1
Sakamoto, Y1
Yoneda, K1
Koide, T1
Tokoro, C1
Abe, Y1
Inamori, M1
Nakagama, H1
Lee, JH1
Jeon, SM1
Ali, O1
Banerjee, S1
Kelly, DF1
Lee, PD1
Beaudot, C1
Merceron, RE1
Lavieuville, M1
Noël, M1
Brohon, J1
Raymond, JP1

Reviews

5 reviews available for metformin and Adenoma

ArticleYear
Suppressive effects of metformin on colorectal adenoma incidence and malignant progression.
    Pathology, research and practice, 2020, Volume: 216, Issue:2

    Topics: Adenoma; Asian People; Colorectal Neoplasms; Diabetes Mellitus, Type 2; Disease Progression; Humans;

2020
Metformin and colorectal cancer: a systematic review, meta-analysis and meta-regression.
    International journal of colorectal disease, 2020, Volume: 35, Issue:8

    Topics: Adenoma; Colorectal Neoplasms; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metformin

2020
Metformin use and the risk of colorectal adenoma: A systematic review and meta-analysis.
    Journal of gastroenterology and hepatology, 2017, Volume: 32, Issue:5

    Topics: Adenoma; Colorectal Neoplasms; Databases, Bibliographic; Diabetes Complications; Diabetes Mellitus;

2017
Metformin therapy and the risk of colorectal adenoma in patients with type 2 diabetes: A meta-analysis.
    Oncotarget, 2017, Jan-31, Volume: 8, Issue:5

    Topics: Adenoma; Aged; Chi-Square Distribution; Colorectal Neoplasms; Diabetes Mellitus, Type 2; Female; Hum

2017
Metformin therapy and risk of colorectal adenomas and colorectal cancer in type 2 diabetes mellitus patients: A systematic review and meta-analysis.
    Oncotarget, 2017, Feb-28, Volume: 8, Issue:9

    Topics: Adenoma; Colorectal Neoplasms; Diabetes Mellitus, Type 2; Humans; Metformin

2017

Trials

2 trials available for metformin and Adenoma

ArticleYear
Metformin for chemoprevention of metachronous colorectal adenoma or polyps in post-polypectomy patients without diabetes: a multicentre double-blind, placebo-controlled, randomised phase 3 trial.
    The Lancet. Oncology, 2016, Volume: 17, Issue:4

    Topics: Adenoma; Adult; Aged; Aged, 80 and over; Chemoprevention; Colonic Polyps; Colonoscopy; Colorectal Ne

2016
Metformin suppresses colorectal aberrant crypt foci in a short-term clinical trial.
    Cancer prevention research (Philadelphia, Pa.), 2010, Volume: 3, Issue:9

    Topics: Aberrant Crypt Foci; Adenoma; Aged; Antineoplastic Agents; Cell Proliferation; Clinical Trials as To

2010

Other Studies

18 other studies available for metformin and Adenoma

ArticleYear
The Emerging Role of Metformin in the Prevention and Treatment of Colorectal Cancer: A Game Changer for the Management of Colorectal Cancer.
    Current diabetes reviews, 2022, Volume: 18, Issue:8

    Topics: Adenoma; Colorectal Neoplasms; Fluorouracil; Humans; Hypoglycemic Agents; Incidence; Metformin

2022
Metformin Use Is Inversely Associated with Prevalent, but Not Incident Colorectal Adenomas.
    Digestive diseases and sciences, 2022, Volume: 67, Issue:10

    Topics: Adenoma; Colonic Polyps; Colonoscopy; Colorectal Neoplasms; Early Detection of Cancer; Humans; Metfo

2022
Risk factors for the occurrence of ampullary tumors: A case-control study.
    United European gastroenterology journal, 2022, Volume: 10, Issue:7

    Topics: Adenoma; Ampulla of Vater; Aspirin; Carcinoma; Case-Control Studies; Common Bile Duct Neoplasms; Duo

2022
Metabolic and Metabolomic Effects of Metformin in Murine Model of Pulmonary Adenoma Formation.
    Nutrition and cancer, 2023, Volume: 75, Issue:3

    Topics: Adenoma; Animals; Disease Models, Animal; Lung Neoplasms; Metformin; Mice; Weight Gain

2023
Establishment of a large-scale patient-derived high-risk colorectal adenoma organoid biobank for high-throughput and high-content drug screening.
    BMC medicine, 2023, 09-04, Volume: 21, Issue:1

    Topics: Adenoma; Biological Specimen Banks; Colorectal Neoplasms; Drug Evaluation, Preclinical; Humans; Metf

2023
Rapid Onset of Diabetic Ketoacidosis After SGLT2 Inhibition in a Patient With Unrecognized Acromegaly.
    The Journal of clinical endocrinology and metabolism, 2017, 05-01, Volume: 102, Issue:5

    Topics: Adenoma; Benzhydryl Compounds; Diabetes Mellitus, Type 2; Diabetic Ketoacidosis; Drug Therapy, Combi

2017
Metformin inhibits proliferation and growth hormone secretion of GH3 pituitary adenoma cells.
    Oncotarget, 2017, Jun-06, Volume: 8, Issue:23

    Topics: Activating Transcription Factor 3; Adenoma; Adult; Aged; Animals; Cell Line, Tumor; Cell Proliferati

2017
[Metformin effect on urethane-induced tumorigenesis in mice].
    Voprosy onkologii, 2012, Volume: 58, Issue:4

    Topics: Adenoma; Administration, Oral; Animals; Anticarcinogenic Agents; Carcinogens; Cell Transformation, N

2012
Pituitary gigantism presenting with depressive mood disorder and diabetic ketoacidosis in an Asian adolescent.
    Journal of pediatric endocrinology & metabolism : JPEM, 2013, Volume: 26, Issue:9-10

    Topics: Adenoma; Adolescent; Adolescent Development; Antineoplastic Agents, Hormonal; Combined Modality Ther

2013
Prevention of colorectal adenomas.
    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, 2015, Volume: 17 Suppl 1

    Topics: Adenoma; Aspirin; Colorectal Neoplasms; Estrogen Receptor alpha; Estrogen Receptor beta; Humans; Lig

2015
Prevention: Tending the gut.
    Nature, 2015, May-14, Volume: 521, Issue:7551

    Topics: Adenoma; Anti-Inflammatory Agents, Non-Steroidal; Cancer Vaccines; Clinical Trials as Topic; Colonic

2015
Metformin use and risk of colorectal adenoma after polypectomy in patients with type 2 diabetes mellitus.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2015, Volume: 24, Issue:11

    Topics: Adenoma; Adult; Aged; Aged, 80 and over; Colon; Colorectal Neoplasms; Diabetes Mellitus, Type 2; Fem

2015
Effect of Insulin and Metformin Combination Treatment on Colon Adenoma and Advanced Adenoma Among DM II.
    Journal of gastrointestinal cancer, 2016, Volume: 47, Issue:4

    Topics: Adenoma; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Diabetes Complication

2016
Fixed-Dose Combinations of Pioglitazone and Metformin for Lung Cancer Prevention.
    Cancer prevention research (Philadelphia, Pa.), 2017, Volume: 10, Issue:2

    Topics: Adenoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Chemoprevention; Dose-Response Rel

2017
The effect of metformin on the recurrence of colorectal adenoma in diabetic patients with previous colorectal adenoma.
    International journal of colorectal disease, 2017, Volume: 32, Issue:8

    Topics: Adenoma; Colorectal Neoplasms; Diabetes Mellitus; Female; Humans; Male; Metformin; Neoplasm Recurren

2017
Metformin use is associated with a decreased incidence of colorectal adenomas in diabetic patients with previous colorectal cancer.
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2012, Volume: 44, Issue:12

    Topics: Adenoma; Adenomatous Polyps; Adult; Aged; Aged, 80 and over; Colonoscopy; Colorectal Neoplasms; Diab

2012
Management of type 2 diabetes mellitus associated with pituitary gigantism.
    Pituitary, 2007, Volume: 10, Issue:4

    Topics: Adenoma; Adolescent; Antineoplastic Agents; Cabergoline; Combined Modality Therapy; Diabetes Mellitu

2007
[Reversible lactic acidosis in a diabetic on high dose metformin (author's transl)].
    Diabete & metabolisme, 1980, Volume: 6, Issue:3

    Topics: Adenoma; Diabetes Complications; Diabetes Mellitus; Diabetic Ketoacidosis; Humans; Lactates; Male; M

1980