metformin has been researched along with Acute Radiation Syndrome in 2 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Acute Radiation Syndrome: A condition caused by a brief whole body exposure to more than one sievert dose equivalent of radiation. Acute radiation syndrome is initially characterized by ANOREXIA; NAUSEA; VOMITING; but can progress to hematological, gastrointestinal, neurological, pulmonary, and other major organ dysfunction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin (250 mg/kg) was effective in protecting splenic cells from a 7 Gy dose in vivo (protection factor = 1." | 1.40 | Metformin exhibits radiation countermeasures efficacy when used alone or in combination with sulfhydryl containing drugs. ( Grdina, DJ; Miller, RC; Murley, JS, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hofer, M | 1 |
| Hoferová, Z | 1 |
| Depeš, D | 1 |
| Falk, M | 1 |
| Miller, RC | 1 |
| Murley, JS | 1 |
| Grdina, DJ | 1 |
1 review available for metformin and Acute Radiation Syndrome
| Article | Year |
|---|---|
Combining Pharmacological Countermeasures to Attenuate the Acute Radiation Syndrome-A Concise Review.
Topics: Acute Radiation Syndrome; Amifostine; Animals; Dinoprostone; Drug Administration Schedule; Drug Comb | 2017 |
1 other study available for metformin and Acute Radiation Syndrome
| Article | Year |
|---|---|
Metformin exhibits radiation countermeasures efficacy when used alone or in combination with sulfhydryl containing drugs.
Topics: Acetylcysteine; Acute Radiation Syndrome; Amifostine; Animals; Captopril; Cell Line, Transformed; Ce | 2014 |