metformin has been researched along with Acute Lung Injury in 5 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Acute Lung Injury: A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study showed that some pathological changes occurring in the lungs of aged rats, such as hemorrhage, edema, and inflammation, improved after metformin treatment; the number of hepatocyte death increased in the AgCLP group, and decreased in the AgMET group." | 8.31 | Effect of metformin on sepsis-associated acute lung injury and gut microbiota in aged rats with sepsis. ( Duo, B; Liu, Y; Lu, Z; Niu, Y; Wan, Y; Wang, S; Zhu, R, 2023) |
| "Treatment with metformin reversed LPS-induced decline of AMPK phosphorylation." | 5.48 | Metformin alleviated endotoxemia-induced acute lung injury via restoring AMPK-dependent suppression of mTOR. ( Dai, J; Huang, J; Jiang, R; Tian, R; Wu, K; Yang, Y; Zhang, L, 2018) |
| "This study showed that some pathological changes occurring in the lungs of aged rats, such as hemorrhage, edema, and inflammation, improved after metformin treatment; the number of hepatocyte death increased in the AgCLP group, and decreased in the AgMET group." | 4.31 | Effect of metformin on sepsis-associated acute lung injury and gut microbiota in aged rats with sepsis. ( Duo, B; Liu, Y; Lu, Z; Niu, Y; Wan, Y; Wang, S; Zhu, R, 2023) |
| "Treatment with metformin reversed LPS-induced decline of AMPK phosphorylation." | 1.48 | Metformin alleviated endotoxemia-induced acute lung injury via restoring AMPK-dependent suppression of mTOR. ( Dai, J; Huang, J; Jiang, R; Tian, R; Wu, K; Yang, Y; Zhang, L, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 2 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wan, Y | 1 |
| Wang, S | 1 |
| Niu, Y | 1 |
| Duo, B | 1 |
| Liu, Y | 1 |
| Lu, Z | 1 |
| Zhu, R | 1 |
| Wang, Y | 2 |
| Chen, H | 1 |
| Sun, C | 1 |
| Shen, H | 1 |
| Cui, X | 1 |
| Wu, K | 1 |
| Tian, R | 1 |
| Huang, J | 1 |
| Yang, Y | 1 |
| Dai, J | 1 |
| Jiang, R | 1 |
| Zhang, L | 1 |
| He, Y | 1 |
| Xu, K | 1 |
| Chao, X | 1 |
| Xu, B | 1 |
| Wu, J | 1 |
| Shen, J | 1 |
| Ren, W | 1 |
| Hu, Y | 1 |
| Vaez, H | 1 |
| Najafi, M | 1 |
| Toutounchi, NS | 1 |
| Barar, J | 1 |
| Barzegari, A | 1 |
| Garjani, A | 1 |
5 other studies available for metformin and Acute Lung Injury
| Article | Year |
|---|---|
Effect of metformin on sepsis-associated acute lung injury and gut microbiota in aged rats with sepsis.
Topics: Acute Lung Injury; Animals; Escherichia coli; Gastrointestinal Microbiome; Inflammation; Interleukin | 2023 |
Metformin attenuates lipopolysaccharide-induced epithelial cell senescence by activating autophagy.
Topics: Acute Lung Injury; Animals; Autophagy; Autophagy-Related Protein 5; Cell Line; Cellular Senescence; | 2021 |
Metformin alleviated endotoxemia-induced acute lung injury via restoring AMPK-dependent suppression of mTOR.
Topics: Acute Lung Injury; AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Cytokines; Endo | 2018 |
AMPK as a potential pharmacological target for alleviating LPS-induced acute lung injury partly via NLRC4 inflammasome pathway inhibition.
Topics: Acute Lung Injury; Age Factors; AMP-Activated Protein Kinases; Animals; Apoptosis Regulatory Protein | 2019 |
Metformin Alleviates Lipopolysaccharide-induced Acute Lung Injury through Suppressing Toll-like Receptor 4 Signaling.
Topics: Acute Lung Injury; AMP-Activated Protein Kinases; Animals; Blotting, Western; Hypoglycemic Agents; L | 2016 |