metformin has been researched along with Acute Kidney Injury in 142 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Acute Kidney Injury: Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Lactic acidosis is a potential adverse event related to metformin therapy." | 9.41 | [Acute Renal Failure, Lactic Acidosis, and Metformin: Two Case Reports and Literature Review]. ( Cesaro, A; Del Piano, C; Del Piano, D; Diglio, A; Faggian, A; Faggian, G; Faggian, R; Salzano, M; Vitagliano, A, 2023) |
| "Metformin-associated lactic acidosis (MALA) is a rare adverse effect that has significant morbidity and mortality." | 9.05 | Osmolar-gap in the setting of metformin-associated lactic acidosis: Case report and a literature review highlighting an apparently unusual association. ( Alamin, M; Elshafei, MN; Mohamed, MFH, 2020) |
| "The current practice concerning timing, mode, and dose of renal replacement therapy (RRT) in patients with metformin-associated lactic acidosis (MALA) with renal failure remains unknown." | 8.95 | Serum lactate level and mortality in metformin-associated lactic acidosis requiring renal replacement therapy: a systematic review of case reports and case series. ( Kuo, CC; Ting, IW; Tsai, CW; Wu, JY; Yeh, HC, 2017) |
| "In our data, preadmission metformin use is associated with a significantly larger decrease in lactate after admission with sepsis or septic shock and with reduced mortality in septic shock." | 8.31 | New potential for an old kid on the block: Impact of premorbid metformin use on lactate kinetics, kidney injury and mortality in sepsis and septic shock, an observational study. ( De Decker, K; De Neve, N; Tackaert, T; Van Moorter, N; Van Vlem, B, 2023) |
| "Metformin-induced lactic acidosis with acute kidney injury is rare but well known." | 8.31 | Daily dose of metformin caused acute kidney injury with lactic acidosis: a case report. ( Ariga, M; Hagita, J; Kitaichi, K; Oida, Y; Soda, M; Teramachi, H, 2023) |
| " Metabolic acidosis in a patient with a history of metformin intake should suggest the possibility of metformin-associated lactic acidosis, which must be treated immediately, without waiting for the results of other examinations, especially in patients with sudden blindness." | 8.31 | Reversible acute blindness in suspected metformin-associated lactic acidosis: a case report. ( Huang, R; Sun, W, 2023) |
| "BACKGROUND Metformin-associated lactic acidosis (MALA) is a relatively rare adverse effect of metformin therapy." | 8.12 | Transient Complete Blindness Due to Metformin-Associated Lactic Acidosis (MALA) Reversed with Hemodialysis. ( Barusya, C; Charokopos, A; Dumic, I; Knopps, L; Rueda Prada, L; Subramanian, A; Zurob, AS, 2022) |
| "Metformin-associated lactic acidosis (MALA) is a rare but life-threatening condition." | 8.12 | A patient with severe metformin-associated lactic acidosis complicated by acute coronary syndrome: a case report. ( Ahmed, A; Gudowski, C; Mammadova, N; Pliquett, RU; Shkodivskyi, P; Soukup, J, 2022) |
| " Here, we present a case of a diabetic patient with acute kidney injury, metformin-associated lactic acidosis, and COVID-19." | 8.02 | Metformin-associated lactic acidosis and acute kidney injury in the era of COVID-19. ( Kalaitzidis, RG; Koukoulaki, M; Theofilis, P; Vlachopanos, G; Vordoni, A, 2021) |
| "Metformin-associated lactic acidosis (MALA) carries a high mortality rate." | 7.96 | Metformin-associated lactic acidosis: reinforcing learning points. ( Creagh, F; Goonoo, MS; Morris, R; Raithatha, A, 2020) |
| "The choice of the specific modality and treatment duration of renal replacement therapy (RRT) to adopt in metformin-associated lactic acidosis (MALA) is still debated." | 7.91 | Sustained low-efficiency dialysis for metformin-associated lactic acidosis in patients with acute kidney injury. ( Fani, F; Ferioli, E; Fiaccadori, E; Gandolfini, I; Greco, P; Locatelli, C; Maccari, C; Maggiore, U; Parenti, E; Regolisti, G, 2019) |
| "154 patients admitted with acute coronary syndrome during months of January 2014 - December 2014; 67 patients used metformin (100% had diabetes mellitus) whereas 87 were not on metformin (31% had diabetes mellitus)." | 7.91 | Metformin, arterial contrast and acute kidney Injury. ( Kaur, N; Lal, A; Trivedi, N, 2019) |
| "A new diagnostic paradigm has been proposed to better categorize causes of Metformin-Associated Lactic Acidosis (MALA)." | 7.88 | Metformin-Induced Lactic Acidosis (MILA): Review of current diagnostic paradigm. ( Al-Khalisy, H; Kaul, P; Krowl, L, 2018) |
| "Metformin is renally excreted and has been associated with the development of lactic acidosis." | 7.85 | Acute kidney injury, plasma lactate concentrations and lactic acidosis in metformin users: A GoDarts study. ( Connelly, PJ; Donnelly, L; Lonergan, M; Pearson, ER; Soto-Pedre, E; Zhou, K, 2017) |
| "Whether metformin precipitates lactic acidosis in patients with chronic kidney disease (CKD) remains under debate." | 7.85 | Risk of acute kidney injury and survival in patients treated with Metformin: an observational cohort study. ( Bell, S; Colhoun, HM; Farran, B; Leese, GP; Lindsay, R; Looker, H; McCrimmon, RJ; McGurnaghan, S; McKeigue, P; McKnight, J; Petrie, JR; Sattar, N; Wild, S, 2017) |
| "Metformin intoxication with lactic acidosis, a potentially lethal condition, may develop in diabetic patients when the drug dose is inappropriate and/or its clearance is reduced." | 7.85 | Treatment of Metformin Intoxication Complicated by Lactic Acidosis and Acute Kidney Injury: The Role of Prolonged Intermittent Hemodialysis. ( Antoniotti, R; Fani, F; Fiaccadori, E; Greco, P; Regolisti, G, 2017) |
| "Metformin-associated lactic acidosis (MALA) is one of the most important drug toxicities with a high morbidity and mortality rate." | 7.83 | Myocardial injury and acute renal failure associated with lactic acidosis due to suicide attempt with metformin. ( Berber, E; Ordu, O; Ozdemir, A; Ozen, B; Sertbas, M; Sertbas, Y, 2016) |
| "To evaluate the strength of association between lactic acidosis (LA) and well-recognized risk factors for LA, particularly the weight of metformin." | 7.83 | Lactic Acidosis in Diabetic Population: Is Metformin Implicated? Results of a Matched Case-Control Study Performed on the Type 2 Diabetes Population of Grenoble Hospital University. ( Chanoine, S; Giai, J; Lepelley, M; Villier, C; Yahiaoui, N, 2016) |
| "To analyze the association between chronic metformin treatment and the development of contrast-induced acute kidney injury (CI-AKI) after primary percutaneous coronary intervention (PCI) for ST segment elevation myocardial infarction (STEMI)." | 7.83 | Metformin and contrast-induced acute kidney injury in diabetic patients treated with primary percutaneous coronary intervention for ST segment elevation myocardial infarction: Amulticenter study. ( Cottin, Y; Feldman, LJ; Juliard, JM; Labalette-Bart, M; Potier, L; Roussel, R; Steg, PG; Zeller, M, 2016) |
| "Metformin-induced lactic acidosis is a rare but severe disease for the individual patients." | 7.81 | [Metformin-induced lactic acidosis : Severe symptoms with difficult diagnostics]. ( Brenner, T; Decker, SO; Hofer, S; Siegler, BH; Ulrich, A; Wortmann, M, 2015) |
| " All cases of lactic acidosis (pH, ≤ 7." | 7.80 | Metformin accumulation: lactic acidosis and high plasmatic metformin levels in a retrospective case series of 66 patients on chronic therapy. ( Giampreti, A; Locatelli, CA; Lonati, D; Manzo, L; Papa, P; Petrolini, VM; Protti, A; Rocchi, L; Rognoni, C; Rolandi, L; Valli, A; Vecchio, S, 2014) |
| "Two patients with type 2 DM developed acute kidney injury and lactic acidosis following colonoscopy despite withholding metformin." | 7.80 | Acute renal failure and metformin-associated lactic acidosis following colonoscopy. ( Connor, SJ; Depczynski, B; Hall, BM; Hussain, MI, 2014) |
| "Metformin associated lactic acidosis (MALA) is a serious complication occurring especially in elderly patients given high doses of the drug." | 7.79 | Monitoring of metformin-induced lactic acidosis in a diabetic patient with acute kidney failure and effect of hemodialysis. ( Amiel, JB; Laforest, C; Merle, L; Pichon, N; Saint-Marcoux, F, 2013) |
| " Metformin-associated lactic acidosis may sometimes be life-threatening." | 7.78 | Metformin-associated lactic acidosis following acute kidney injury. Efficacious treatment with continuous renal replacement therapy. ( Dahan, E; Dichtwald, S; Ekstein, MP; Sorkine, P; Weinbroum, AA, 2012) |
| "To evaluate the significance of diabetes mellitus and metformin in patients admitted to medical ICU with lactic acidosis." | 7.78 | Lactic acidosis in medical ICU - the role of diabetes mellitus and metformin. ( Charvat, J; Havlin, J; Hloch, O; Masopust, J, 2012) |
| "We describe two cases of severe metformin-related lactic acidosis with underlying acute kidney injury, which were treated with dialysis." | 7.77 | Metformin-related lactic acidosis in patients with acute kidney injury. ( Devetzis, V; Georgoulidou, A; Panagoutsos, S; Passadakis, P; Theodoridis, M; Thodis, E; Vargemezis, V, 2011) |
| "We present an uncommon case of lactic acidosis after concomitant administration of Metformin and Tenofovir." | 7.77 | Lactic acidosis after concomitant treatment with metformin and tenofovir in a patient with HIV infection. ( Alivanis, P; Aperis, G; Arvanitis, A; Paliouras, C; Zervos, A, 2011) |
| "From January 2004 to November 2008, 11 cases of metformin-associated lactic acidosis were seen at a medical center in Taiwan." | 7.75 | Impact of acute kidney injury on metformin-associated lactic acidosis. ( Wen, YK, 2009) |
| "Metformin-associated lactic acidosis (MALA) is a rare but serious clinical entity." | 7.73 | Metformin-associated lactic acidosis precipitated by acute renal failure. ( Shenoy, C, 2006) |
| "In type II diabetes treated with metformin, lactic acidosis is a rare but severe complication." | 7.72 | [Metformin-associated lactic acidosis precipitated by acute renal failure]. ( Azoulay, E; Galy-Floc'h, M; Mariot, J; Pertek, JP; Vidal, S, 2003) |
| "We report 4 cases of lactic acidosis in diabetic patients usually treated with metformin." | 7.72 | [Metformin-associated lactic acidosis remains a serious complication of metformin therapy]. ( Giunti, C; Grimaud, D; Ichai, C; Levraut, J; Orban, JC, 2003) |
| "A patient with acute renal failure associated with lactic acidosis as a result of concurrent treatment with metformin is described." | 7.72 | Metformin lactic acidosis, acute renal failure and rofecoxib. ( Price, G, 2003) |
| "Metformin-induced lactic acidosis is a common side effect in patients with renal insufficiency." | 7.71 | [Metformin-associated lactic acidosis with acute renal failure in type 2 diabetes mellitus]. ( Berner, B; Hagenlocher, S; Hummel, KM; Kleine, P; Müller, GA; Ramadori, G; Ritzel, U; Strutz, F, 2002) |
| "To determine the respective role of metformin accumulation and tissue hypoxia in triggering metformin-associated lactic acidosis (MALA), we measured plasma (PM) and red blood cell (RM) metformin concentrations in 14 patients with MALA and in 58 diabetic patients on well-tolerated chronic metformin treatment." | 7.69 | Metformin-associated lactic acidosis in diabetic patients with acute renal failure. A critical analysis of its pathogenesis and prognosis. ( De Cagny, B; Fournier, A; Lacroix, C; Lalau, JD, 1994) |
| "A 69-year-old diabetic woman with diffuse atherosclerosis presented with acute renal failure due to contrast nephropathy and severe metformin-induced lactic acidosis." | 7.69 | Metformin-induced lactic acidosis associated with acute renal failure. ( Ben-Yehuda, A; Dranitzki-Elhalel, M; Popovtzer, M; Safadi, R, 1996) |
| "A 55 year old diabetic women treated with chlorpropamide and metformin for three years presented with acute oliguric renal failure and lactic acidosis from which she died." | 7.67 | Lactic acidosis due to metformin therapy in a low risk patient. ( Leatherdale, BA; Tymms, DJ, 1988) |
| "Metformin was prescribed to 99 patients (61%) ("M+"group) during the hospitalization, 62 patients were in "M-"group." | 5.91 | [Use of metformin in patients with type 2 diabetes and acute myocardial infarction: safety and impact on glycemic control]. ( Korotina, MA; Pochinka, IG; Strongin, LG, 2023) |
| " We report on a case of acute kidney injury in a patient using alectinib for less than 2 weeks and on serum sodium and creatinine during long-term use of alectinib." | 5.72 | Acute kidney injury and long-term renal effects of alectinib in anaplastic lymphoma kinase-positive non-small cell lung carcinoma: a case report. ( Janssen, WMT; Roosma, E; van Londen, M; van Putten, JWG; Vogels, S, 2022) |
| "Despite paucity of data, it is common practice to discontinue metformin before invasive coronary angiography due to an alleged risk of Metformin-Associated Lactic Acidosis (M-ALA)." | 5.69 | Safety of metformin continuation in diabetic patients undergoing invasive coronary angiography: the NO-STOP single arm trial. ( Avvedimento, M; Chiarito, M; Condello, F; Condorelli, G; Diez Gil, JL; Federici, M; Ferrante, G; Garcia-Garcia, HM; Liccardo, G; Maurina, M; Mehran, R; Pagnotta, P; Piccolo, R; Regazzoli, D; Reimers, B; Sanz-Sanchez, J; Stefanini, G, 2023) |
| "Metformin was associated with increased OR (CI) for AKI, 1." | 5.62 | Is metformin associated with acute kidney injury? A case-control study of patients with type 2 diabetes admitted with acute infection. ( Carlson, N; Gerds, TA; Gislason, GH; Hommel, K; Nelveg-Kristensen, KE; Nissen, AB; Schou, M; Schytz, PA; Torp-Pedersen, C, 2021) |
| "We included patients with AKI and type 2 diabetes (T2DM) from the Medical Information Mart for Intensive Care database." | 5.62 | Association between metformin use on admission and outcomes in intensive care unit patients with acute kidney injury and type 2 diabetes: A retrospective cohort study. ( Chen, W; Chen, X; Wen, D; Xiong, X; Yang, Q; Zhang, Z; Zheng, J, 2021) |
| "A 58-year-old female with known type 2 diabetes mellitus continued to take her usual medications, including metformin, an ACE inhibitor and a non-steroidal anti-inflammatory drug, while suffering from diarrhoea and vomiting." | 5.62 | Metformin-associated lactic acidosis. ( Fadden, EJ; Longley, C; Mahambrey, T, 2021) |
| "Pretreatment of metformin could markedly attenuate cisplatin-induced acute kidney injury, tubular cell apoptosis and inflammatory cell accumulation in the kidneys." | 5.43 | Metformin Protects Against Cisplatin-Induced Tubular Cell Apoptosis and Acute Kidney Injury via AMPKα-regulated Autophagy Induction. ( Dai, C; Feng, Y; Gui, Y; He, W; Li, J; Liu, X; Ren, J; Yang, J; Zeng, Z, 2016) |
| "Lactic acidosis is a potential adverse event related to metformin therapy." | 5.41 | [Acute Renal Failure, Lactic Acidosis, and Metformin: Two Case Reports and Literature Review]. ( Cesaro, A; Del Piano, C; Del Piano, D; Diglio, A; Faggian, A; Faggian, G; Faggian, R; Salzano, M; Vitagliano, A, 2023) |
| "A metformin level was 150 μg/mL (therapeutic 1-2 μg/mL)." | 5.37 | Occult metformin toxicity in three patients with profound lactic acidosis. ( Gaieski, D; Perrone, J; Phillips, C, 2011) |
| "Metformin is an antihyperglycemic agent commonly used in diabetic patients." | 5.37 | The nephrologist's role in metformin-induced lactic acidosis. ( Basterrechea, MA; de Arriba, G; Gómez-Navarro, L; Hernández-Sevillano, B; Pérez del Valle, KM; Rodríguez-Palomares, JR; Sánchez-Heras, M; Tallón, S; Torres-Guinea, M, 2011) |
| "Metformin, however, has the potential to increase serumlactate." | 5.33 | [Metformin-associated lactic acidosis in a patient with pre-existing risk factors]. ( Becker, C; Luginbühl, A; Pittl, U; Schlienger, R, 2005) |
| "Metformin is a biguanide commonly used in type 2 diabetes and considered to be a safe drug with minimal side effects." | 5.32 | Metformin induced acute pancreatitis precipitated by renal failure. ( Mallick, S, 2004) |
| "Metformin is an oral hypoglycemic agent belonging to the class of biguanides that are commonly used in the treatment of type II diabetes mellitus." | 5.31 | Metformin-associated lactic acidosis in a low risk patient. ( Ellis, AK; Iliescu, EA, 2001) |
| "The association between metformin use and renal function needs further to be elucidated since data are insufficient whether metformin affects renal function in higher risk populations such as after ST-elevation myocardial infarction (STEMI)." | 5.20 | Effect of Metformin on Renal Function After Primary Percutaneous Coronary Intervention in Patients Without Diabetes Presenting with ST-elevation Myocardial Infarction: Data from the GIPS-III Trial. ( Damman, K; Lexis, CP; Lipsic, E; Nijsten, MW; Posma, RA; Touw, DJ; van der Harst, P; van der Horst, IC; van Veldhuisen, DJ, 2015) |
| "Metformin-associated lactic acidosis (MALA) is a rare adverse effect that has significant morbidity and mortality." | 5.05 | Osmolar-gap in the setting of metformin-associated lactic acidosis: Case report and a literature review highlighting an apparently unusual association. ( Alamin, M; Elshafei, MN; Mohamed, MFH, 2020) |
| "The current practice concerning timing, mode, and dose of renal replacement therapy (RRT) in patients with metformin-associated lactic acidosis (MALA) with renal failure remains unknown." | 4.95 | Serum lactate level and mortality in metformin-associated lactic acidosis requiring renal replacement therapy: a systematic review of case reports and case series. ( Kuo, CC; Ting, IW; Tsai, CW; Wu, JY; Yeh, HC, 2017) |
| "In our data, preadmission metformin use is associated with a significantly larger decrease in lactate after admission with sepsis or septic shock and with reduced mortality in septic shock." | 4.31 | New potential for an old kid on the block: Impact of premorbid metformin use on lactate kinetics, kidney injury and mortality in sepsis and septic shock, an observational study. ( De Decker, K; De Neve, N; Tackaert, T; Van Moorter, N; Van Vlem, B, 2023) |
| "Metformin-induced lactic acidosis with acute kidney injury is rare but well known." | 4.31 | Daily dose of metformin caused acute kidney injury with lactic acidosis: a case report. ( Ariga, M; Hagita, J; Kitaichi, K; Oida, Y; Soda, M; Teramachi, H, 2023) |
| " Metabolic acidosis in a patient with a history of metformin intake should suggest the possibility of metformin-associated lactic acidosis, which must be treated immediately, without waiting for the results of other examinations, especially in patients with sudden blindness." | 4.31 | Reversible acute blindness in suspected metformin-associated lactic acidosis: a case report. ( Huang, R; Sun, W, 2023) |
| "BACKGROUND Metformin-associated lactic acidosis (MALA) is a relatively rare adverse effect of metformin therapy." | 4.12 | Transient Complete Blindness Due to Metformin-Associated Lactic Acidosis (MALA) Reversed with Hemodialysis. ( Barusya, C; Charokopos, A; Dumic, I; Knopps, L; Rueda Prada, L; Subramanian, A; Zurob, AS, 2022) |
| "Metformin-associated lactic acidosis (MALA) is a rare but life-threatening condition." | 4.12 | A patient with severe metformin-associated lactic acidosis complicated by acute coronary syndrome: a case report. ( Ahmed, A; Gudowski, C; Mammadova, N; Pliquett, RU; Shkodivskyi, P; Soukup, J, 2022) |
| "Discontinuation of metformin treatment is a frequently used approach in clinical practice in diabetic ST-segment elevation myocardial infarction patients using metformin in order to reduce the risk of contrast-induced acute kidney injury." | 4.12 | Metformin and CI-AKI Risk in STEMI: Evaluation Using Propensity Score Weighting Method. ( Batgerel, U; Efe, SÇ; Kalkan, S; Karabay, CY; Karagöz, A; Kırma, C; Oduncu, V; Şimşek, B; Sungur, MA; Tanboğa, İH; Yılmaz, F; Yılmaz, MF, 2022) |
| " Spironolactone, furosemide, and trimethoprim with sulfamethoxazole are medicines that, in particular, need to be used carefully and monitored closely in patients in the community at risk of acute kidney injury." | 4.12 | Medicine-Induced Acute Kidney Injury Findings from Spontaneous Reporting Systems, Sequence Symmetry Analysis and a Case-Control Study with a Focus on Medicines Used in Primary Care. ( Kassie, GM; Kerr, M; Moffat, A; Pratt, N; Roughead, EE, 2022) |
| " Here, we present a case of a diabetic patient with acute kidney injury, metformin-associated lactic acidosis, and COVID-19." | 4.02 | Metformin-associated lactic acidosis and acute kidney injury in the era of COVID-19. ( Kalaitzidis, RG; Koukoulaki, M; Theofilis, P; Vlachopanos, G; Vordoni, A, 2021) |
| "Metformin-associated lactic acidosis (MALA) carries a high mortality rate." | 3.96 | Metformin-associated lactic acidosis: reinforcing learning points. ( Creagh, F; Goonoo, MS; Morris, R; Raithatha, A, 2020) |
| "The choice of the specific modality and treatment duration of renal replacement therapy (RRT) to adopt in metformin-associated lactic acidosis (MALA) is still debated." | 3.91 | Sustained low-efficiency dialysis for metformin-associated lactic acidosis in patients with acute kidney injury. ( Fani, F; Ferioli, E; Fiaccadori, E; Gandolfini, I; Greco, P; Locatelli, C; Maccari, C; Maggiore, U; Parenti, E; Regolisti, G, 2019) |
| "154 patients admitted with acute coronary syndrome during months of January 2014 - December 2014; 67 patients used metformin (100% had diabetes mellitus) whereas 87 were not on metformin (31% had diabetes mellitus)." | 3.91 | Metformin, arterial contrast and acute kidney Injury. ( Kaur, N; Lal, A; Trivedi, N, 2019) |
| "A new diagnostic paradigm has been proposed to better categorize causes of Metformin-Associated Lactic Acidosis (MALA)." | 3.88 | Metformin-Induced Lactic Acidosis (MILA): Review of current diagnostic paradigm. ( Al-Khalisy, H; Kaul, P; Krowl, L, 2018) |
| "The application of iodinated contrast medium has become a risk factor for metformin-associated lactic acidosis (MALA), which leads to the accumulation of metformin in vivo is one of the principal reasons for MALA." | 3.88 | Involvement of organic cation transporter 2 in the metformin-associated increased lactate levels caused by contrast-induced nephropathy. ( Dai, Y; Huo, X; Liu, K; Liu, Z; Ma, X; Meng, Q; Peng, J; Sun, H; Wang, C; Yang, S, 2018) |
| "Metformin is renally excreted and has been associated with the development of lactic acidosis." | 3.85 | Acute kidney injury, plasma lactate concentrations and lactic acidosis in metformin users: A GoDarts study. ( Connelly, PJ; Donnelly, L; Lonergan, M; Pearson, ER; Soto-Pedre, E; Zhou, K, 2017) |
| "Whether metformin precipitates lactic acidosis in patients with chronic kidney disease (CKD) remains under debate." | 3.85 | Risk of acute kidney injury and survival in patients treated with Metformin: an observational cohort study. ( Bell, S; Colhoun, HM; Farran, B; Leese, GP; Lindsay, R; Looker, H; McCrimmon, RJ; McGurnaghan, S; McKeigue, P; McKnight, J; Petrie, JR; Sattar, N; Wild, S, 2017) |
| "Metformin intoxication with lactic acidosis, a potentially lethal condition, may develop in diabetic patients when the drug dose is inappropriate and/or its clearance is reduced." | 3.85 | Treatment of Metformin Intoxication Complicated by Lactic Acidosis and Acute Kidney Injury: The Role of Prolonged Intermittent Hemodialysis. ( Antoniotti, R; Fani, F; Fiaccadori, E; Greco, P; Regolisti, G, 2017) |
| "Metformin-associated lactic acidosis (MALA) is one of the most important drug toxicities with a high morbidity and mortality rate." | 3.83 | Myocardial injury and acute renal failure associated with lactic acidosis due to suicide attempt with metformin. ( Berber, E; Ordu, O; Ozdemir, A; Ozen, B; Sertbas, M; Sertbas, Y, 2016) |
| "The role of metformin in the development of lactic acidosis (LA) in the setting of acute renal failure (ARF) is debated." | 3.83 | Dose-related effects of metformin on acid-base balance and renal function in patients with diabetes who develop acute renal failure: a cross-sectional study. ( Angelini, C; Badalamenti, S; Calvetta, A; Cucchiari, D; Merizzoli, E; Morenghi, E; Podestà, MA; Ponticelli, C, 2016) |
| "To evaluate the strength of association between lactic acidosis (LA) and well-recognized risk factors for LA, particularly the weight of metformin." | 3.83 | Lactic Acidosis in Diabetic Population: Is Metformin Implicated? Results of a Matched Case-Control Study Performed on the Type 2 Diabetes Population of Grenoble Hospital University. ( Chanoine, S; Giai, J; Lepelley, M; Villier, C; Yahiaoui, N, 2016) |
| "To analyze the association between chronic metformin treatment and the development of contrast-induced acute kidney injury (CI-AKI) after primary percutaneous coronary intervention (PCI) for ST segment elevation myocardial infarction (STEMI)." | 3.83 | Metformin and contrast-induced acute kidney injury in diabetic patients treated with primary percutaneous coronary intervention for ST segment elevation myocardial infarction: Amulticenter study. ( Cottin, Y; Feldman, LJ; Juliard, JM; Labalette-Bart, M; Potier, L; Roussel, R; Steg, PG; Zeller, M, 2016) |
| "Metformin-induced lactic acidosis is a rare but severe disease for the individual patients." | 3.81 | [Metformin-induced lactic acidosis : Severe symptoms with difficult diagnostics]. ( Brenner, T; Decker, SO; Hofer, S; Siegler, BH; Ulrich, A; Wortmann, M, 2015) |
| " All cases of lactic acidosis (pH, ≤ 7." | 3.80 | Metformin accumulation: lactic acidosis and high plasmatic metformin levels in a retrospective case series of 66 patients on chronic therapy. ( Giampreti, A; Locatelli, CA; Lonati, D; Manzo, L; Papa, P; Petrolini, VM; Protti, A; Rocchi, L; Rognoni, C; Rolandi, L; Valli, A; Vecchio, S, 2014) |
| "Two patients with type 2 DM developed acute kidney injury and lactic acidosis following colonoscopy despite withholding metformin." | 3.80 | Acute renal failure and metformin-associated lactic acidosis following colonoscopy. ( Connor, SJ; Depczynski, B; Hall, BM; Hussain, MI, 2014) |
| "Metformin associated lactic acidosis (MALA) is a serious complication occurring especially in elderly patients given high doses of the drug." | 3.79 | Monitoring of metformin-induced lactic acidosis in a diabetic patient with acute kidney failure and effect of hemodialysis. ( Amiel, JB; Laforest, C; Merle, L; Pichon, N; Saint-Marcoux, F, 2013) |
| " Metformin-associated lactic acidosis may sometimes be life-threatening." | 3.78 | Metformin-associated lactic acidosis following acute kidney injury. Efficacious treatment with continuous renal replacement therapy. ( Dahan, E; Dichtwald, S; Ekstein, MP; Sorkine, P; Weinbroum, AA, 2012) |
| "To evaluate the significance of diabetes mellitus and metformin in patients admitted to medical ICU with lactic acidosis." | 3.78 | Lactic acidosis in medical ICU - the role of diabetes mellitus and metformin. ( Charvat, J; Havlin, J; Hloch, O; Masopust, J, 2012) |
| "We describe two cases of severe metformin-related lactic acidosis with underlying acute kidney injury, which were treated with dialysis." | 3.77 | Metformin-related lactic acidosis in patients with acute kidney injury. ( Devetzis, V; Georgoulidou, A; Panagoutsos, S; Passadakis, P; Theodoridis, M; Thodis, E; Vargemezis, V, 2011) |
| "We present an uncommon case of lactic acidosis after concomitant administration of Metformin and Tenofovir." | 3.77 | Lactic acidosis after concomitant treatment with metformin and tenofovir in a patient with HIV infection. ( Alivanis, P; Aperis, G; Arvanitis, A; Paliouras, C; Zervos, A, 2011) |
| "Lactic acidosis is a rare and often lethal complication of metformin therapy." | 3.77 | Prolonged hemodialysis for severe metformin intoxication. ( Juvvadi, R; McFarren, C; Rifkin, SI; Weinstein, SS, 2011) |
| " We present the case of a patient who developed acute renal failure and lactic acidosis while using creatine and metformin simultaneously." | 3.76 | Severe metabolic acidosis secondary to coadministration of creatine and metformin, a case report. ( Mani, M; Saidi, H, 2010) |
| "From January 2004 to November 2008, 11 cases of metformin-associated lactic acidosis were seen at a medical center in Taiwan." | 3.75 | Impact of acute kidney injury on metformin-associated lactic acidosis. ( Wen, YK, 2009) |
| "Metformin is a commonly used oral antidiabetic drug which can cause lactic acidosis." | 3.75 | How to explain a PaO2 of 140 mmHg in a venous line? ( Corno, L; Fichera, M; Landoni, G; Mizzi, A; Nuzzi, M; Zangrillo, A, 2009) |
| "We report a case of severe metabolic acidosis associated with acute renal failure and septicaemia following treatment with maximal therapeutic doses of metformin and diclofenac." | 3.73 | Intensive care treatment of severe mixed metabolic acidosis. ( Akeson, J; Christensson, A; Schmidt, A, 2005) |
| "Metformin-associated lactic acidosis (MALA) is a rare but serious clinical entity." | 3.73 | Metformin-associated lactic acidosis precipitated by acute renal failure. ( Shenoy, C, 2006) |
| "The increasing prevalence of Type 2 diabetes and its treatment with metformin might result in more cases of lactic acidosis." | 3.73 | Severe acidosis in patients taking metformin--rapid reversal and survival despite high APACHE score. ( Grant, I; McKnight, JA; Nyirenda, MJ; Price, G; Sandeep, T, 2006) |
| "In type II diabetes treated with metformin, lactic acidosis is a rare but severe complication." | 3.72 | [Metformin-associated lactic acidosis precipitated by acute renal failure]. ( Azoulay, E; Galy-Floc'h, M; Mariot, J; Pertek, JP; Vidal, S, 2003) |
| "We report 4 cases of lactic acidosis in diabetic patients usually treated with metformin." | 3.72 | [Metformin-associated lactic acidosis remains a serious complication of metformin therapy]. ( Giunti, C; Grimaud, D; Ichai, C; Levraut, J; Orban, JC, 2003) |
| "A patient with acute renal failure associated with lactic acidosis as a result of concurrent treatment with metformin is described." | 3.72 | Metformin lactic acidosis, acute renal failure and rofecoxib. ( Price, G, 2003) |
| "Metformin-induced lactic acidosis is a common side effect in patients with renal insufficiency." | 3.71 | [Metformin-associated lactic acidosis with acute renal failure in type 2 diabetes mellitus]. ( Berner, B; Hagenlocher, S; Hummel, KM; Kleine, P; Müller, GA; Ramadori, G; Ritzel, U; Strutz, F, 2002) |
| "To determine the respective role of metformin accumulation and tissue hypoxia in triggering metformin-associated lactic acidosis (MALA), we measured plasma (PM) and red blood cell (RM) metformin concentrations in 14 patients with MALA and in 58 diabetic patients on well-tolerated chronic metformin treatment." | 3.69 | Metformin-associated lactic acidosis in diabetic patients with acute renal failure. A critical analysis of its pathogenesis and prognosis. ( De Cagny, B; Fournier, A; Lacroix, C; Lalau, JD, 1994) |
| "A 69-year-old diabetic woman with diffuse atherosclerosis presented with acute renal failure due to contrast nephropathy and severe metformin-induced lactic acidosis." | 3.69 | Metformin-induced lactic acidosis associated with acute renal failure. ( Ben-Yehuda, A; Dranitzki-Elhalel, M; Popovtzer, M; Safadi, R, 1996) |
| "A 55 year old diabetic women treated with chlorpropamide and metformin for three years presented with acute oliguric renal failure and lactic acidosis from which she died." | 3.67 | Lactic acidosis due to metformin therapy in a low risk patient. ( Leatherdale, BA; Tymms, DJ, 1988) |
| "Nondiabetic patients with LAHNSCC were enrolled in the current study to receive escalating doses of metformin and CRT based on the modified toxicity probability interval design." | 2.94 | Phase 1 dose-finding study of metformin in combination with concurrent cisplatin and radiotherapy in patients with locally advanced head and neck squamous cell cancer. ( Desai, J; Desai, PB; Gulati, S; Gutkind, JS; Jandarov, R; Mierzwa, M; Molinolo, A; Morris, JC; Palackdharry, SM; Riaz, MK; Sadraei, NH; Takiar, V; Wise-Draper, TM; Zhu, Z, 2020) |
| "Diabetes and sepsis are important causes of morbidity and mortality worldwide, and diabetic patients represent the largest population experiencing post-sepsis complications and rising mortality." | 2.72 | Type 2 diabetes mellitus and sepsis: state of the art, certainties and missing evidence. ( Brizzi, MF; Carlin, M; Costantini, E; Porta, M, 2021) |
| "Metformin is a frontline hypoglycemic agent, which is mainly prescribed to manage type 2 diabetes mellitus with obesity." | 2.66 | Metformin: the updated protective property in kidney disease. ( Chen, X; Guo, F; Liao, S; Liu, HF; Lu, X; Pan, Q; Yang, C; Zhao, C, 2020) |
| "Metformin has been shown to exert beneficial effects on the kidney in various clinical trials and experimental studies performed in divergent rodent models representing different types of renal diseases going from AKI to CKD." | 2.58 | Metformin: A Candidate Drug for Renal Diseases. ( Corremans, R; D'Haese, PC; Neven, E; Verhulst, A; Vervaet, BA, 2018) |
| "Metformin was prescribed to 99 patients (61%) ("M+"group) during the hospitalization, 62 patients were in "M-"group." | 1.91 | [Use of metformin in patients with type 2 diabetes and acute myocardial infarction: safety and impact on glycemic control]. ( Korotina, MA; Pochinka, IG; Strongin, LG, 2023) |
| " We report on a case of acute kidney injury in a patient using alectinib for less than 2 weeks and on serum sodium and creatinine during long-term use of alectinib." | 1.72 | Acute kidney injury and long-term renal effects of alectinib in anaplastic lymphoma kinase-positive non-small cell lung carcinoma: a case report. ( Janssen, WMT; Roosma, E; van Londen, M; van Putten, JWG; Vogels, S, 2022) |
| "Metformin was associated with increased OR (CI) for AKI, 1." | 1.62 | Is metformin associated with acute kidney injury? A case-control study of patients with type 2 diabetes admitted with acute infection. ( Carlson, N; Gerds, TA; Gislason, GH; Hommel, K; Nelveg-Kristensen, KE; Nissen, AB; Schou, M; Schytz, PA; Torp-Pedersen, C, 2021) |
| "We included patients with AKI and type 2 diabetes (T2DM) from the Medical Information Mart for Intensive Care database." | 1.62 | Association between metformin use on admission and outcomes in intensive care unit patients with acute kidney injury and type 2 diabetes: A retrospective cohort study. ( Chen, W; Chen, X; Wen, D; Xiong, X; Yang, Q; Zhang, Z; Zheng, J, 2021) |
| "A 58-year-old female with known type 2 diabetes mellitus continued to take her usual medications, including metformin, an ACE inhibitor and a non-steroidal anti-inflammatory drug, while suffering from diarrhoea and vomiting." | 1.62 | Metformin-associated lactic acidosis. ( Fadden, EJ; Longley, C; Mahambrey, T, 2021) |
| "Colchicine led to an increase in inflammatory cells within the renal parenchyma." | 1.56 | Repurposing of metformin and colchicine reveals differential modulation of acute and chronic kidney injury. ( El-Rashid, M; Ghimire, K; Julovi, S; Li, J; Meijles, DN; Minhas, N; Nguyen-Ngo, D; Rogers, NM, 2020) |
| "Metformin was used to delineate the role of AMPK in mitigating the hypertension-induced CV and renal dysfunction." | 1.51 | Metformin attenuates cardiovascular and renal injury in uninephrectomized rats on DOCA-salt: Involvement of AMPK and miRNAs in cardioprotection. ( Amara, VR; Surapaneni, SK; Tikoo, K, 2019) |
| "Gentamicin (GM) is an antibiotic related to aminoglycoside group that is used in treating Gram-negative bacterial infections." | 1.51 | Combinational effect of curcumin and metformin against gentamicin-induced nephrotoxicity: Involvement of antioxidative, anti-inflammatory and antiapoptotic pathway. ( Cao, L; Han, J; Kumar Sah, S; Xie, Y; Zhi, D, 2019) |
| "The latter can provoke an acute renal failure, which may lead to a toxic accumulation of these pharmacological agents and/or increase their nephrotoxicity." | 1.46 | [Importance of stopping some medications in case of gastrointestinal disturbances leading to dehydration]. ( Krzesinski, JM; Scheen, AJ, 2017) |
| "Pretreatment of metformin could markedly attenuate cisplatin-induced acute kidney injury, tubular cell apoptosis and inflammatory cell accumulation in the kidneys." | 1.43 | Metformin Protects Against Cisplatin-Induced Tubular Cell Apoptosis and Acute Kidney Injury via AMPKα-regulated Autophagy Induction. ( Dai, C; Feng, Y; Gui, Y; He, W; Li, J; Liu, X; Ren, J; Yang, J; Zeng, Z, 2016) |
| "Metformin is and has been considered as first-line therapy for type 2 diabetes for over a quarter of a century." | 1.43 | Should Restrictions Be Relaxed for Metformin Use in Chronic Kidney Disease? No, We Should Never Again Compromise Safety! ( Kalantar-Zadeh, K; Kovesdy, CP, 2016) |
| "Metformin is and has been considered as first-line therapy for type 2 diabetes for over a quarter of a century." | 1.43 | Should Restrictions Be Relaxed for Metformin Use in Chronic Kidney Disease? Yes, They Should Be Relaxed! What's the Fuss? ( Bakris, GL; Molitch, ME, 2016) |
| " Thus, this study was designed to investigate whether a Korean red ginseng extract (KRG) prevents renal impairment and pharmacokinetic changes by metformin in rats with renal failure induced by gentamicin." | 1.39 | Effects of Korean red ginseng extract on acute renal failure induced by gentamicin and pharmacokinetic changes by metformin in rats. ( Chin, YW; Choi, YH; Lee, YK, 2013) |
| "Metformin treatment significantly attenuated the increase in malondialdehyde and tROS generation and restores the decrease in both enzymatic and non-enzymatic antioxidants." | 1.39 | Effect of metformin against cisplatin induced acute renal injury in rats: a biochemical and histoarchitectural evaluation. ( Kuncha, M; Putcha, UK; Sahu, BD; Sistla, R, 2013) |
| "A metformin level was 150 μg/mL (therapeutic 1-2 μg/mL)." | 1.37 | Occult metformin toxicity in three patients with profound lactic acidosis. ( Gaieski, D; Perrone, J; Phillips, C, 2011) |
| "Metformin is an antihyperglycemic agent commonly used in diabetic patients." | 1.37 | The nephrologist's role in metformin-induced lactic acidosis. ( Basterrechea, MA; de Arriba, G; Gómez-Navarro, L; Hernández-Sevillano, B; Pérez del Valle, KM; Rodríguez-Palomares, JR; Sánchez-Heras, M; Tallón, S; Torres-Guinea, M, 2011) |
| "Metformin was administered intravenously at a dose of 50mg/kg to control and U-ARF rats." | 1.36 | Slower clearance of intravenous metformin in rats with acute renal failure induced by uranyl nitrate: contribution of slower renal and non-renal clearances. ( Choi, YH; Lee, I; Lee, MG, 2010) |
| "The development of acute renal failure significantly complicates intravascular contrast medium (CM) use and is linked with high morbidity and mortality." | 1.34 | Canadian Association of Radiologists: consensus guidelines for the prevention of contrast-induced nephropathy. ( Barrett, B; Benko, A; Capusten, B; Fraser-Hill, M; Magner, P; Myers, A; Owen, RJ, 2007) |
| "Metformin is a biguanide used in the treatment of obese adults with type 2 diabetes mellitus; metformin decreases mortality by 36% in comparison to conventional treatment." | 1.34 | [Overdose of metformin secondary to acute renal insufficiency: a report of six cases]. ( Ambrós Checa, A; Gómez Grande, L; Martín Rodríguez, C; Ortega Carnicer, J; Portilla Botelho, M; Ruiz Lorenzo, F, 2007) |
| "Metformin, however, has the potential to increase serumlactate." | 1.33 | [Metformin-associated lactic acidosis in a patient with pre-existing risk factors]. ( Becker, C; Luginbühl, A; Pittl, U; Schlienger, R, 2005) |
| "To analyze, in acute renal failure (ARF) in diabetic rats, how moderate functional ARF would modify metformin (MET) pharmacokinetics and if plasma and renal tissue MET accumulation could aggravate renal insufficiency and/or elicit plasma lactate accumulation." | 1.32 | Mild acute renal failure potentiates metformin accumulation in the diabetic rat kidney without further impairment of renal function. ( Barthelmebs, M; Grima, M; Imbs, JI; Krieger, JP; Radziuk, J; Rapin, JR; Wiernsperger, N, 2003) |
| "A progressively deteriorating haemodynamic state led to an exploratory laparotomy." | 1.32 | [Lactic acidosis and acute abdomen from biguanide intoxication]. ( Barwing, J; Moerer, O; Neumann, P, 2004) |
| "Metformin is a biguanide commonly used in type 2 diabetes and considered to be a safe drug with minimal side effects." | 1.32 | Metformin induced acute pancreatitis precipitated by renal failure. ( Mallick, S, 2004) |
| "Troglitazone is a thiazolidinedione with insulin-sensitizing activities when administered to humans or animals with type 2 diabetes mellitus." | 1.31 | Case of the month. Hepatic and renal failure in a patient taking troglitazone and metformin. ( Chaudhry, MU; Simmons, DL, 2001) |
| "Metformin is an oral hypoglycemic agent belonging to the class of biguanides that are commonly used in the treatment of type II diabetes mellitus." | 1.31 | Metformin-associated lactic acidosis in a low risk patient. ( Ellis, AK; Iliescu, EA, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (3.52) | 18.7374 |
| 1990's | 14 (9.86) | 18.2507 |
| 2000's | 34 (23.94) | 29.6817 |
| 2010's | 56 (39.44) | 24.3611 |
| 2020's | 33 (23.24) | 2.80 |
| Authors | Studies |
|---|---|
| Hayashi, A | 1 |
| Ishimura, T | 1 |
| Sugimoto, H | 1 |
| Suzuki, H | 1 |
| Hamasaki, A | 1 |
| Tsukamoto, T | 1 |
| Vordoni, A | 1 |
| Theofilis, P | 1 |
| Vlachopanos, G | 1 |
| Koukoulaki, M | 1 |
| Kalaitzidis, RG | 1 |
| Rueda Prada, L | 1 |
| Knopps, L | 1 |
| Dumic, I | 1 |
| Barusya, C | 1 |
| Subramanian, A | 1 |
| Charokopos, A | 1 |
| Zurob, AS | 1 |
| Mammadova, N | 1 |
| Soukup, J | 1 |
| Shkodivskyi, P | 1 |
| Gudowski, C | 1 |
| Ahmed, A | 1 |
| Pliquett, RU | 1 |
| Kalkan, S | 1 |
| Karagöz, A | 1 |
| Efe, SÇ | 1 |
| Sungur, MA | 1 |
| Şimşek, B | 1 |
| Yılmaz, MF | 1 |
| Batgerel, U | 1 |
| Yılmaz, F | 1 |
| Tanboğa, İH | 1 |
| Oduncu, V | 1 |
| Karabay, CY | 1 |
| Kırma, C | 1 |
| Harley, G | 1 |
| Katerelos, M | 1 |
| Gleich, K | 1 |
| de Souza, DP | 1 |
| Narayana, VK | 1 |
| Kemp, BE | 1 |
| Power, DA | 1 |
| Mount, PF | 1 |
| Roughead, EE | 1 |
| Kerr, M | 1 |
| Moffat, A | 1 |
| Kassie, GM | 1 |
| Pratt, N | 1 |
| van Londen, M | 1 |
| Roosma, E | 1 |
| Vogels, S | 1 |
| van Putten, JWG | 1 |
| Janssen, WMT | 1 |
| Qiao, H | 1 |
| Li, Y | 6 |
| Xu, B | 1 |
| Lu, Z | 1 |
| Zhang, J | 4 |
| Meng, D | 1 |
| He, S | 1 |
| Huang, J | 2 |
| Van Moorter, N | 3 |
| Tackaert, T | 3 |
| De Decker, K | 3 |
| Van Vlem, B | 3 |
| De Neve, N | 3 |
| Chiarito, M | 1 |
| Sanz-Sanchez, J | 1 |
| Piccolo, R | 1 |
| Condello, F | 1 |
| Liccardo, G | 1 |
| Maurina, M | 1 |
| Avvedimento, M | 1 |
| Regazzoli, D | 1 |
| Pagnotta, P | 1 |
| Garcia-Garcia, HM | 1 |
| Mehran, R | 1 |
| Federici, M | 1 |
| Condorelli, G | 1 |
| Diez Gil, JL | 1 |
| Reimers, B | 1 |
| Ferrante, G | 1 |
| Stefanini, G | 1 |
| Korotina, MA | 1 |
| Pochinka, IG | 1 |
| Strongin, LG | 1 |
| Faggian, G | 1 |
| Cesaro, A | 1 |
| Faggian, R | 1 |
| Vitagliano, A | 1 |
| Del Piano, C | 1 |
| Del Piano, D | 1 |
| Salzano, M | 1 |
| Diglio, A | 1 |
| Faggian, A | 1 |
| Ariga, M | 1 |
| Hagita, J | 1 |
| Soda, M | 1 |
| Oida, Y | 1 |
| Teramachi, H | 1 |
| Kitaichi, K | 1 |
| Huang, R | 1 |
| Sun, W | 1 |
| Gulati, S | 1 |
| Desai, J | 1 |
| Palackdharry, SM | 1 |
| Morris, JC | 1 |
| Zhu, Z | 1 |
| Jandarov, R | 1 |
| Riaz, MK | 1 |
| Takiar, V | 1 |
| Mierzwa, M | 1 |
| Gutkind, JS | 1 |
| Molinolo, A | 1 |
| Desai, PB | 1 |
| Sadraei, NH | 1 |
| Wise-Draper, TM | 1 |
| Corchia, A | 2 |
| Wynckel, A | 2 |
| Djerada, Z | 2 |
| Lalau, JD | 4 |
| Bennis, Y | 2 |
| De Broe, M | 1 |
| Yu, Q | 1 |
| Zhu, JJ | 1 |
| Liu, WX | 1 |
| Pan, Q | 1 |
| Lu, X | 1 |
| Zhao, C | 1 |
| Liao, S | 1 |
| Chen, X | 3 |
| Guo, F | 1 |
| Yang, C | 1 |
| Liu, HF | 1 |
| Nguépy Keubo, FR | 1 |
| Mboua, PC | 1 |
| Djifack Tadongfack, T | 1 |
| Fokouong Tchoffo, E | 1 |
| Tasson Tatang, C | 1 |
| Ide Zeuna, J | 1 |
| Noupoue, EM | 1 |
| Tsoplifack, CB | 1 |
| Folefack, GO | 1 |
| Kettani, M | 1 |
| Bandelier, P | 1 |
| Huo, J | 1 |
| Li, H | 4 |
| Yu, D | 1 |
| Arulsamy, N | 1 |
| AlAbbad, S | 1 |
| Sardot, T | 1 |
| Lekashvili, O | 1 |
| Decato, D | 1 |
| Lelj, F | 1 |
| Alexander Ross, JB | 1 |
| Rosenberg, E | 1 |
| Nazir, H | 1 |
| Muthuswamy, N | 1 |
| Louis, C | 1 |
| Jose, S | 1 |
| Prakash, J | 1 |
| Buan, MEM | 1 |
| Flox, C | 1 |
| Chavan, S | 1 |
| Shi, X | 1 |
| Kauranen, P | 1 |
| Kallio, T | 1 |
| Maia, G | 1 |
| Tammeveski, K | 1 |
| Lymperopoulos, N | 1 |
| Carcadea, E | 1 |
| Veziroglu, E | 1 |
| Iranzo, A | 1 |
| M Kannan, A | 1 |
| Arunamata, A | 1 |
| Tacy, TA | 1 |
| Kache, S | 1 |
| Mainwaring, RD | 1 |
| Ma, M | 1 |
| Maeda, K | 1 |
| Punn, R | 1 |
| Noguchi, S | 1 |
| Hahn, S | 3 |
| Iwasa, Y | 3 |
| Ling, J | 2 |
| Voccio, JP | 2 |
| Kim, Y | 3 |
| Song, J | 3 |
| Bascuñán, J | 2 |
| Chu, Y | 1 |
| Tomita, M | 1 |
| Cazorla, M | 1 |
| Herrera, E | 1 |
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| Hoplock, LB | 1 |
| Lobchuk, MM | 1 |
| Lemoine, J | 1 |
| Li, X | 10 |
| Henson, MA | 1 |
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| Qiu, J | 1 |
| Swaroop, S | 1 |
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| Tsybin, YO | 1 |
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| Alias, A | 1 |
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| Naveed, A | 1 |
| Jilani, K | 1 |
| Siddique, AB | 1 |
| Akbar, M | 1 |
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| Mushtaq, Z | 1 |
| Sikandar, M | 1 |
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| Zhou, B | 1 |
| Zhang, S | 2 |
| Xing, YL | 1 |
| Chen, MA | 1 |
| Sun, Y | 1 |
| Neradilek, MB | 1 |
| Wu, XT | 1 |
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| Huang, W | 1 |
| Cui, Y | 1 |
| Yang, QQ | 1 |
| Li, HW | 1 |
| Zhao, XQ | 1 |
| Hossein Rashidi, B | 1 |
| Tarafdari, A | 1 |
| Ghazimirsaeed, ST | 1 |
| Shahrokh Tehraninezhad, E | 1 |
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| Ghazimirsaeed, SM | 1 |
| Jafarabadi, M | 1 |
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| Rubagumya, F | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Study of Metformin Overdose in Adult Patients Treated at the University Hospital of Nancy: Single-center Descriptive Retrospective Observational Study[NCT04762966] | 50 participants (Anticipated) | Observational | 2021-03-01 | Recruiting | |||
| Assessment of the Effect of Atorvastatin and N-acetyl Cysteine on Prevention of Contrast Induced Nephropathy in Patients Undergoing Coronary Angiography CIN[NCT06139952] | Phase 4 | 120 participants (Anticipated) | Interventional | 2023-12-01 | Not yet recruiting | ||
| Intravenous vs. Oral Hydration to Reduce the Risk of Post-Contrast Acute Kidney Injury After Intravenous Contrast-Enhanced Computed Tomography in Patients With Severe Chronic Kidney Disease (ENRICH): A Randomized Controlled Trial[NCT05283512] | 254 participants (Anticipated) | Interventional | 2022-04-20 | Recruiting | |||
| Effect of the Administration of Melatonin and Metformin on Glycemic Control, Genotoxicity and Cytotoxicity Markers in Patients With Prediabetes: Pilot Study[NCT03848533] | Phase 2 | 42 participants (Anticipated) | Interventional | 2019-08-22 | Recruiting | ||
| Metformin Continuation Versus Interruption Following Coronary Angiography: a Pilot Randomized Controlled Trial[NCT03980990] | Phase 4 | 500 participants (Anticipated) | Interventional | 2019-06-17 | Recruiting | ||
| A Prospective, Randomized Open-Label Phase II Study of the Safety and Tolerability of Metformin in Combination With Standard Antimicrobial Treatment of Pulmonary Tuberculosis in People With TB and Co-infected With HIV[NCT04930744] | Phase 2 | 112 participants (Anticipated) | Interventional | 2021-08-03 | Recruiting | ||
| Prospective, Double Blind, Randomized Trial: Meniscal Repair With or Without Augmentation Utilizing Platelet Rich Plasma.[NCT01991353] | 0 participants (Actual) | Interventional | 2015-07-31 | Withdrawn (stopped due to Lack of funding) | |||
| The Prevention Contrast-Induced Acute Kidney Injury With the Triple Combination of Hydration With Physiological Saline, N-Acetylcysteine and Sodium Bicarbonate[NCT01210456] | Phase 3 | 458 participants (Anticipated) | Interventional | 2009-10-31 | Enrolling by invitation | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
13 reviews available for metformin and Acute Kidney Injury
| Article | Year |
|---|---|
Metformin Can Be Safely Used in Patients Exposed to Contrast Media: A Systematic Review and Meta-Analysis.
Topics: Acute Kidney Injury; Contrast Media; Humans; Incidence; Metformin; Odds Ratio | 2022 |
[Acute Renal Failure, Lactic Acidosis, and Metformin: Two Case Reports and Literature Review].
Topics: Acidosis, Lactic; Acute Kidney Injury; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metfo | 2023 |
Metformin: the updated protective property in kidney disease.
Topics: Acidosis, Lactic; Acute Kidney Injury; AMP-Activated Protein Kinases; Animals; Disease Models, Anima | 2020 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Osmolar-gap in the setting of metformin-associated lactic acidosis: Case report and a literature review highlighting an apparently unusual association.
Topics: Acid-Base Imbalance; Acidosis, Lactic; Acute Kidney Injury; Diabetes Mellitus, Type 2; Humans; Hypog | 2020 |
Type 2 diabetes mellitus and sepsis: state of the art, certainties and missing evidence.
Topics: Acute Kidney Injury; Diabetes Mellitus, Type 2; Humans; Insulin; Metformin; Sepsis | 2021 |
What are the risks and benefits of temporarily discontinuing medications to prevent acute kidney injury? A systematic review and meta-analysis.
Topics: Acute Kidney Injury; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Ant | 2017 |
Serum lactate level and mortality in metformin-associated lactic acidosis requiring renal replacement therapy: a systematic review of case reports and case series.
Topics: Acidosis, Lactic; Acute Kidney Injury; Adult; Aged; Biomarkers; Female; Humans; Hypoglycemic Agents; | 2017 |
Post-contrast acute kidney injury. Part 2: risk stratification, role of hydration and other prophylactic measures, patients taking metformin and chronic dialysis patients : Recommendations for updated ESUR Contrast Medium Safety Committee guidelines.
Topics: Acute Kidney Injury; Adult; Child; Contraindications, Drug; Contrast Media; Drug Substitution; Femal | 2018 |
Post-contrast acute kidney injury. Part 2: risk stratification, role of hydration and other prophylactic measures, patients taking metformin and chronic dialysis patients : Recommendations for updated ESUR Contrast Medium Safety Committee guidelines.
Topics: Acute Kidney Injury; Adult; Child; Contraindications, Drug; Contrast Media; Drug Substitution; Femal | 2018 |
Post-contrast acute kidney injury. Part 2: risk stratification, role of hydration and other prophylactic measures, patients taking metformin and chronic dialysis patients : Recommendations for updated ESUR Contrast Medium Safety Committee guidelines.
Topics: Acute Kidney Injury; Adult; Child; Contraindications, Drug; Contrast Media; Drug Substitution; Femal | 2018 |
Post-contrast acute kidney injury. Part 2: risk stratification, role of hydration and other prophylactic measures, patients taking metformin and chronic dialysis patients : Recommendations for updated ESUR Contrast Medium Safety Committee guidelines.
Topics: Acute Kidney Injury; Adult; Child; Contraindications, Drug; Contrast Media; Drug Substitution; Femal | 2018 |
Drug discontinuation before contrast procedures and the effect on acute kidney injury and other clinical outcomes: a systematic review protocol.
Topics: Acute Kidney Injury; Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents, Non-Steroid | 2018 |
Metformin: A Candidate Drug for Renal Diseases.
Topics: Acidosis, Lactic; Acute Kidney Injury; AMP-Activated Protein Kinases; Animals; Clinical Trials as To | 2018 |
Strategies to reduce the risk of contrast-induced nephropathy.
Topics: Acute Kidney Injury; Consensus Development Conferences as Topic; Contrast Media; Emergencies; Fluid | 2006 |
Prevention of contrast-induced nephropathy: a critical review.
Topics: Acetylcysteine; Acute Kidney Injury; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting | 2007 |
4 trials available for metformin and Acute Kidney Injury
| Article | Year |
|---|---|
Safety of metformin continuation in diabetic patients undergoing invasive coronary angiography: the NO-STOP single arm trial.
Topics: Acidosis, Lactic; Acute Kidney Injury; Coronary Angiography; Diabetes Mellitus; Humans; Hypoglycemic | 2023 |
Phase 1 dose-finding study of metformin in combination with concurrent cisplatin and radiotherapy in patients with locally advanced head and neck squamous cell cancer.
Topics: Acute Kidney Injury; Aged; Anemia; Antineoplastic Combined Chemotherapy Protocols; Chemoradiotherapy | 2020 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Effect of Metformin on Renal Function After Primary Percutaneous Coronary Intervention in Patients Without Diabetes Presenting with ST-elevation Myocardial Infarction: Data from the GIPS-III Trial.
Topics: Acute Kidney Injury; Creatinine; Diabetes Mellitus; Female; Glomerular Filtration Rate; Humans; Hypo | 2015 |
126 other studies available for metformin and Acute Kidney Injury
| Article | Year |
|---|---|
Metformin-associated lactic acidosis exacerbated by acute kidney injury in an overseas traveler.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Angiotensin-Converting Enzyme Inhibitors; Diuretics; Fe | 2022 |
Metformin-associated lactic acidosis and acute kidney injury in the era of COVID-19.
Topics: Acidosis, Lactic; Acute Kidney Injury; COVID-19; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Age | 2021 |
Transient Complete Blindness Due to Metformin-Associated Lactic Acidosis (MALA) Reversed with Hemodialysis.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Blindness; Diabetes Mellitus, Type 2; Diarrhea; Female; | 2022 |
A patient with severe metformin-associated lactic acidosis complicated by acute coronary syndrome: a case report.
Topics: Acidosis, Lactic; Acute Coronary Syndrome; Acute Kidney Injury; Bicarbonates; Diabetes Mellitus, Typ | 2022 |
Metformin and CI-AKI Risk in STEMI: Evaluation Using Propensity Score Weighting Method.
Topics: Acute Kidney Injury; Contrast Media; Creatinine; Diabetes Mellitus; Humans; Metformin; Percutaneous | 2022 |
Blocking AMPK signalling to acetyl-CoA carboxylase increases cisplatin-induced acute kidney injury and suppresses the benefit of metformin.
Topics: Acetyl-CoA Carboxylase; Acute Kidney Injury; AMP-Activated Protein Kinases; Animals; Cisplatin; Fatt | 2022 |
Medicine-Induced Acute Kidney Injury Findings from Spontaneous Reporting Systems, Sequence Symmetry Analysis and a Case-Control Study with a Focus on Medicines Used in Primary Care.
Topics: Acute Kidney Injury; Adverse Drug Reaction Reporting Systems; Amlodipine; Amphotericin B; Australia; | 2022 |
Acute kidney injury and long-term renal effects of alectinib in anaplastic lymphoma kinase-positive non-small cell lung carcinoma: a case report.
Topics: Acute Kidney Injury; Aged; Anaplastic Lymphoma Kinase; Anti-Inflammatory Agents; Antineoplastic Agen | 2022 |
New potential for an old kid on the block: Impact of premorbid metformin use on lactate kinetics, kidney injury and mortality in sepsis and septic shock, an observational study.
Topics: Acute Kidney Injury; Humans; Kidney; Lactic Acid; Metformin; Retrospective Studies; Sepsis; Shock, S | 2023 |
New potential for an old kid on the block: Impact of premorbid metformin use on lactate kinetics, kidney injury and mortality in sepsis and septic shock, an observational study.
Topics: Acute Kidney Injury; Humans; Kidney; Lactic Acid; Metformin; Retrospective Studies; Sepsis; Shock, S | 2023 |
New potential for an old kid on the block: Impact of premorbid metformin use on lactate kinetics, kidney injury and mortality in sepsis and septic shock, an observational study.
Topics: Acute Kidney Injury; Humans; Kidney; Lactic Acid; Metformin; Retrospective Studies; Sepsis; Shock, S | 2023 |
New potential for an old kid on the block: Impact of premorbid metformin use on lactate kinetics, kidney injury and mortality in sepsis and septic shock, an observational study.
Topics: Acute Kidney Injury; Humans; Kidney; Lactic Acid; Metformin; Retrospective Studies; Sepsis; Shock, S | 2023 |
[Use of metformin in patients with type 2 diabetes and acute myocardial infarction: safety and impact on glycemic control].
Topics: Acute Kidney Injury; Diabetes Mellitus, Type 2; Glycemic Control; Humans; Hypoglycemic Agents; Lacti | 2023 |
Daily dose of metformin caused acute kidney injury with lactic acidosis: a case report.
Topics: Acidosis, Lactic; Acute Kidney Injury; Creatinine; Diabetes Mellitus, Type 2; Humans; Kidney Tubular | 2023 |
Reversible acute blindness in suspected metformin-associated lactic acidosis: a case report.
Topics: Acidosis; Acidosis, Lactic; Acute Kidney Injury; Blindness; Diabetes Mellitus, Type 2; Female; Human | 2023 |
Authors' reply to the comment on « Metformin-Related lactic acidosis with acute kidney injury: results of a French observationnal multicenter study ».
Topics: Acidosis, Lactic; Acute Kidney Injury; Humans; Hypoglycemic Agents; Metformin | 2020 |
Comment on 'metformin-related lactic acidosis with acute kidney injury: results of a French observational multicenter study'.
Topics: Acidosis, Lactic; Acute Kidney Injury; Humans; Hypoglycemic Agents; Metformin | 2020 |
Effect of continuous use of metformin on kidney function in diabetes patients with acute myocardial infarction undergoing primary percutaneous coronary intervention.
Topics: Acute Kidney Injury; Aged; Biomarkers; Contrast Media; Creatinine; Diabetes Mellitus, Type 2; Female | 2020 |
Metformin-associated lactic acidosis: reinforcing learning points.
Topics: Acidosis, Lactic; Acute Kidney Injury; Bicarbonates; Continuous Renal Replacement Therapy; Diabetes | 2020 |
Is metformin associated with acute kidney injury? A case-control study of patients with type 2 diabetes admitted with acute infection.
Topics: Acute Kidney Injury; Case-Control Studies; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibi | 2021 |
Is there an association between metformin use and clinical outcomes in diabetes patients with COVID-19?
Topics: Acute Kidney Injury; Adult; Aged; Cardiotonic Agents; COVID-19; Diabetes Mellitus, Type 2; Extracorp | 2021 |
Repurposing of metformin and colchicine reveals differential modulation of acute and chronic kidney injury.
Topics: Acute Kidney Injury; Animals; Colchicine; Drug Repositioning; Humans; Kidney Failure, Chronic; Metfo | 2020 |
Association between metformin use on admission and outcomes in intensive care unit patients with acute kidney injury and type 2 diabetes: A retrospective cohort study.
Topics: Acute Kidney Injury; Critical Care; Diabetes Mellitus, Type 2; Humans; Intensive Care Units; Metform | 2021 |
Case 15-2021: A 76-Year-Old Woman with Nausea, Diarrhea, and Acute Kidney Failure.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Coronary Artery Disease; Creatinine; Diabetes Mellitus, | 2021 |
Metformin-associated lactic acidosis.
Topics: Acidosis, Lactic; Acute Kidney Injury; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agent | 2021 |
Metformin use may be associated with reduced risk-adjusted mortality in patients with AKI and diabetes in the ICU: If associated with lactic acidosis, especially in shocked patients, we need to eliminate it as quickly as possible through RRT!
Topics: Acidosis, Lactic; Acute Kidney Injury; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Inten | 2021 |
Acute kidney injury, plasma lactate concentrations and lactic acidosis in metformin users: A GoDarts study.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Aged, 80 and over; Case-Control Studies; Diabetes Melli | 2017 |
[Importance of stopping some medications in case of gastrointestinal disturbances leading to dehydration].
Topics: Acute Kidney Injury; Anti-Inflammatory Agents, Non-Steroidal; Dehydration; Humans; Hypoglycemic Agen | 2017 |
Risk of acute kidney injury and survival in patients treated with Metformin: an observational cohort study.
Topics: Acidosis, Lactic; Acute Kidney Injury; Age Distribution; Aged; Cohort Studies; Comorbidity; Diabetes | 2017 |
Diabetes mellitus: Complex interplay between metformin, AKI and lactic acidosis.
Topics: Acidosis, Lactic; Acute Kidney Injury; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metfo | 2017 |
Further clarifying the relationship between metformin, acute kidney injury and lactic acidosis.
Topics: Acidosis, Lactic; Acute Kidney Injury; Humans; Hypoglycemic Agents; Metformin | 2017 |
Clarifying the relationship between metformin, acute kidney injury and lactic acidosis.
Topics: Acidosis, Lactic; Acute Kidney Injury; Humans; Hypoglycemic Agents; Metformin | 2017 |
Contrast-induced acute kidney injury/ contrast-induced nephropathy may be related to additional risk factors.
Topics: Acute Kidney Injury; Coronary Angiography; Humans; Metformin; Risk Factors | 2018 |
Metformin-Induced Lactic Acidosis (MILA): Review of current diagnostic paradigm.
Topics: Acidosis, Lactic; Acute Kidney Injury; Creatinine; Diabetes Mellitus, Type 2; Humans; Hypoglycemic A | 2018 |
Alteration of renal excretion pathways in gentamicin-induced renal injury in rats.
Topics: Acute Kidney Injury; Animals; Antiporters; ATP Binding Cassette Transporter, Subfamily G, Member 2; | 2018 |
Metformin-associated lactic acidosis: Are we looking in the right direction?
Topics: Acidosis, Lactic; Acute Kidney Injury; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metfo | 2020 |
Involvement of organic cation transporter 2 in the metformin-associated increased lactate levels caused by contrast-induced nephropathy.
Topics: Acidosis, Lactic; Acute Kidney Injury; Animals; Cell Line; Contrast Media; Disease Models, Animal; H | 2018 |
Metformin attenuates cardiovascular and renal injury in uninephrectomized rats on DOCA-salt: Involvement of AMPK and miRNAs in cardioprotection.
Topics: Acute Kidney Injury; AMP-Activated Protein Kinases; Animals; Desoxycorticosterone Acetate; Hemodynam | 2019 |
Sustained low-efficiency dialysis for metformin-associated lactic acidosis in patients with acute kidney injury.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Female; H | 2019 |
Correlation of metformin with intravenous iodinated contrast media and precautions.
Topics: Acute Kidney Injury; Contrast Media; Creatinine; Diabetes Mellitus; Drug Interactions; Humans; Hypog | 2019 |
Metformin, arterial contrast and acute kidney Injury.
Topics: Acute Kidney Injury; Contrast Media; Coronary Angiography; Diabetes Mellitus; Humans; Metformin; Ret | 2019 |
Combinational effect of curcumin and metformin against gentamicin-induced nephrotoxicity: Involvement of antioxidative, anti-inflammatory and antiapoptotic pathway.
Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents; Apoptosis; Curcumin; Drug Combinations; Gent | 2019 |
Metformin-related lactic acidosis with acute kidney injury: results of a French observational multicenter study.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Aged, 80 and over; Female; Humans; Hydrogen-Ion Concent | 2020 |
Effects of Korean red ginseng extract on acute renal failure induced by gentamicin and pharmacokinetic changes by metformin in rats.
Topics: Acute Kidney Injury; Animals; Anti-Bacterial Agents; Drug Interactions; Gentamicins; Ginsenosides; H | 2013 |
Metformin nephrotoxicity insights: will they change clinical management?
Topics: Acute Kidney Injury; Animals; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Ther | 2014 |
Metformin accumulation: lactic acidosis and high plasmatic metformin levels in a retrospective case series of 66 patients on chronic therapy.
Topics: Acidosis, Lactic; Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Chronic Disease; Creatinine; | 2014 |
Metformin-associated lactic acidosis in an older adult after colonoscopy: an uncommon trigger for a rare complication.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged, 80 and over; Colonoscopy; Female; Humans; Hypoglycemic | 2013 |
Rictor/mTORC2 protects against cisplatin-induced tubular cell death and acute kidney injury.
Topics: Acute Kidney Injury; Animals; Apoptosis; Autophagy; Carrier Proteins; Cell Survival; Cells, Cultured | 2014 |
Acute renal failure and metformin-associated lactic acidosis following colonoscopy.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Colonoscopy; Diabetes Mellitus, Type 2; Female; Humans; | 2014 |
[Metformin-induced lactic acidosis : Severe symptoms with difficult diagnostics].
Topics: Acidosis, Lactic; Acute Kidney Injury; Carbon Dioxide; Diabetes Mellitus, Type 2; Epinephrine; Human | 2015 |
Protective effect of metformin on renal injury of C57BL/6J mouse treated with high fat diet.
Topics: Acute Kidney Injury; Animals; Cyclic AMP-Dependent Protein Kinases; Diet, High-Fat; Hypoglycemic Age | 2014 |
Unexpectedly long half-life of metformin elimination in cases of metformin accumulation.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Algorithms; Blood; Diabetes Mellitus, Type 2; Diabetic | 2016 |
The risks and benefits of patients temporarily discontinuing medications in the event of an intercurrent illness: a systematic review protocol.
Topics: Acute Kidney Injury; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Ant | 2015 |
Myocardial injury and acute renal failure associated with lactic acidosis due to suicide attempt with metformin.
Topics: Acidosis, Lactic; Acute Kidney Injury; Emergency Medical Services; Humans; Hypoglycemic Agents; Male | 2016 |
Dose-related effects of metformin on acid-base balance and renal function in patients with diabetes who develop acute renal failure: a cross-sectional study.
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Acute Kidney Injury; Adult; Aged; Cross-Sectional Studies; | 2016 |
Lactic Acidosis in Diabetic Population: Is Metformin Implicated? Results of a Matched Case-Control Study Performed on the Type 2 Diabetes Population of Grenoble Hospital University.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Aged, 80 and over; Biomarkers; Case-Control Studies; Di | 2016 |
Metformin Protects Against Cisplatin-Induced Tubular Cell Apoptosis and Acute Kidney Injury via AMPKα-regulated Autophagy Induction.
Topics: Acute Kidney Injury; AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Apoptosis; Autop | 2016 |
Should Restrictions Be Relaxed for Metformin Use in Chronic Kidney Disease? No, We Should Never Again Compromise Safety!
Topics: Acidosis, Lactic; Acute Kidney Injury; Creatinine; Diabetes Mellitus, Type 2; Glomerular Filtration | 2016 |
Should Restrictions Be Relaxed for Metformin Use in Chronic Kidney Disease? Yes, They Should Be Relaxed! What's the Fuss?
Topics: Acidosis, Lactic; Acute Kidney Injury; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Metfo | 2016 |
Metformin and contrast-induced acute kidney injury in diabetic patients treated with primary percutaneous coronary intervention for ST segment elevation myocardial infarction: Amulticenter study.
Topics: Acute Kidney Injury; Aged; Contrast Media; Coronary Angiography; Creatinine; Diabetes Mellitus, Type | 2016 |
Metformin-associated risk of acute dialysis in patients with type 2 diabetes: A nationwide cohort study.
Topics: Acute Kidney Injury; Aged; Cohort Studies; Denmark; Diabetes Mellitus, Type 2; Female; Humans; Hypog | 2016 |
Treatment of Metformin Intoxication Complicated by Lactic Acidosis and Acute Kidney Injury: The Role of Prolonged Intermittent Hemodialysis.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Humans; Hypoglycemic Agents; Male; Metformin; Renal Dia | 2017 |
Occult metformin toxicity in three patients with profound lactic acidosis.
Topics: Acidosis, Lactic; Acute Kidney Injury; Adult; Aged; Diabetes Mellitus, Type 2; Emergency Service, Ho | 2011 |
Impact of acute kidney injury on metformin-associated lactic acidosis.
Topics: Academic Medical Centers; Acidosis, Lactic; Acute Kidney Injury; Aged; Anti-Bacterial Agents; Bicarb | 2009 |
Does glucose infusion exacerbate metformin-associated lactate acidosis? A case report.
Topics: Acidosis, Lactic; Acute Kidney Injury; Colectomy; Colitis, Ulcerative; Diabetes Mellitus, Type 2; Fe | 2009 |
Slower clearance of intravenous metformin in rats with acute renal failure induced by uranyl nitrate: contribution of slower renal and non-renal clearances.
Topics: Acute Kidney Injury; Animals; Disease Models, Animal; Injections, Intravenous; Kidney Function Tests | 2010 |
Metformin and lactic acidosis. Metformin: framed again?
Topics: Acidosis, Lactic; Acute Kidney Injury; Glomerular Filtration Rate; Humans; Hypoglycemic Agents; Metf | 2009 |
Severe metabolic acidosis secondary to coadministration of creatine and metformin, a case report.
Topics: Acidosis, Lactic; Acute Kidney Injury; Adult; Creatine; Diagnosis, Differential; Dietary Supplements | 2010 |
How to explain a PaO2 of 140 mmHg in a venous line?
Topics: Acidosis, Lactic; Acute Kidney Injury; Blood Gas Analysis; Cell Respiration; Fatal Outcome; Humans; | 2009 |
Metformin-related lactic acidosis in patients with acute kidney injury.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Contraindications; Diabetes Mellitus, Type 2; Female; H | 2011 |
Lactic acidosis after concomitant treatment with metformin and tenofovir in a patient with HIV infection.
Topics: Acidosis, Lactic; Acute Kidney Injury; Adenine; Aged; Anti-HIV Agents; Diabetes Mellitus, Type 2; Dr | 2011 |
Acute kidney injury associated with metformin.
Topics: Acidosis, Lactic; Acute Kidney Injury; Adult; Aged; Female; Humans; Hypoglycemic Agents; Male; Metfo | 2011 |
Prolonged hemodialysis for severe metformin intoxication.
Topics: Acidosis, Lactic; Acute Kidney Injury; Drug Overdose; Humans; Hypoglycemic Agents; Male; Metformin; | 2011 |
Preactivation of AMPK by metformin may ameliorate the epithelial cell damage caused by renal ischemia.
Topics: Acute Kidney Injury; AMP-Activated Protein Kinases; Animals; Antimetabolites; Antimycin A; Cell Line | 2011 |
The nephrologist's role in metformin-induced lactic acidosis.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibi | 2011 |
Metformin-associated lactic acidosis following acute kidney injury. Efficacious treatment with continuous renal replacement therapy.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Aged, 80 and over; Biomarkers; Creatinine; Female; Huma | 2012 |
Type 2 diabetes, metformin and lactic acidosis-defining the risk and promoting safe practice.
Topics: Acidosis, Lactic; Acute Kidney Injury; Female; Humans; Hypoglycemic Agents; Male; Metformin; Renal D | 2012 |
Rapid recovery from acute kidney injury in a patient with metformin-associated lactic acidosis and hypothermia.
Topics: Acidosis, Lactic; Acute Kidney Injury; Anti-Bacterial Agents; Comorbidity; Female; Humans; Hypotherm | 2012 |
Patient education on the benefit and risks of medications goes beyond metformin.
Topics: Acidosis, Lactic; Acute Kidney Injury; Female; Humans; Hypoglycemic Agents; Male; Metformin; Renal D | 2012 |
Monitoring of metformin-induced lactic acidosis in a diabetic patient with acute kidney failure and effect of hemodialysis.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic | 2013 |
Lactic acidosis in medical ICU - the role of diabetes mellitus and metformin.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Critical Care; Diabetes Mellitus, Type 2; Female; Hospi | 2012 |
Effect of metformin against cisplatin induced acute renal injury in rats: a biochemical and histoarchitectural evaluation.
Topics: Acute Kidney Injury; Animals; Antineoplastic Agents; Antioxidants; Ascorbic Acid; Cisplatin; Glutath | 2013 |
[Metformin-associated lactic acidosis with acute renal failure in type 2 diabetes mellitus].
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Dose-Resp | 2002 |
[Metformin-associated lactic acidosis with acute renal failure in type 2 diabetes mellitus]].
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Dose-Resp | 2002 |
Mild acute renal failure potentiates metformin accumulation in the diabetic rat kidney without further impairment of renal function.
Topics: Acute Kidney Injury; Animals; Blood Pressure; Creatinine; Diabetes Mellitus, Experimental; Hypoglyce | 2003 |
[Metformin-associated lactic acidosis precipitated by acute renal failure].
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Blood Gas Analysis; Diabetes Mellitus, Type 2; Female; | 2003 |
[Metformin-associated lactic acidosis remains a serious complication of metformin therapy].
Topics: Acidosis, Lactic; Acute Kidney Injury; Adult; Aged; Diabetes Complications; Diabetes Mellitus, Type | 2003 |
Metformin-associated lactic acidosis and acute renal failure in a type 2 diabetic patient.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic | 2003 |
Metformin lactic acidosis, acute renal failure and rofecoxib.
Topics: Acidosis, Lactic; Acute Kidney Injury; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhib | 2003 |
[Lactic acidosis and acute abdomen from biguanide intoxication].
Topics: Abdomen, Acute; Acidosis, Lactic; Acute Kidney Injury; Aged; Diabetes Mellitus, Type 2; Female; Hemo | 2004 |
Metformin induced acute pancreatitis precipitated by renal failure.
Topics: Acidosis, Lactic; Acute Disease; Acute Kidney Injury; Angiotensin-Converting Enzyme Inhibitors; Anti | 2004 |
[Acute kidney failure and severe lactic acidosis caused by metformin successfully treated with hemodialysis].
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Humans; Hypoglycemic Agents; Male; Metformin; Remission | 2004 |
Severe metformin intoxication with lactic acidosis in an adolescent.
Topics: Acidosis, Lactic; Acute Kidney Injury; Adolescent; Drug Overdose; Female; Humans; Metformin; Renal D | 2005 |
Intensive care treatment of severe mixed metabolic acidosis.
Topics: Abdominal Abscess; Acidosis; Acute Kidney Injury; Aged; Anti-Inflammatory Agents, Non-Steroidal; Blo | 2005 |
[Metformin-associated lactic acidosis in a patient with pre-existing risk factors].
Topics: Acidosis, Lactic; Acute Kidney Injury; Contraindications; Diabetes Complications; Diabetes Mellitus, | 2005 |
Metformin-associated lactic acidosis precipitated by acute renal failure.
Topics: Acidosis, Lactic; Acute Kidney Injury; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Male; | 2006 |
Severe acidosis in patients taking metformin--rapid reversal and survival despite high APACHE score.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Aged, 80 and over; APACHE; Diabetes Mellitus, Type 2; E | 2006 |
Metformin-induced pancreatitis: A possible adverse drug effect during acute renal failure.
Topics: Acute Disease; Acute Kidney Injury; Diabetes Mellitus; Female; Humans; Hypoglycemic Agents; Metformi | 2006 |
Acute renal failure from contrast medium: beware patients taking metformin...
Topics: Acute Kidney Injury; Contraindications; Contrast Media; Diabetes Mellitus, Type 2; Humans; Hypoglyce | 2006 |
[Acute pancreatitis, acute kidney failure, metformin intoxication and villous rectal adenoma].
Topics: Acidosis, Lactic; Acute Kidney Injury; Adenoma, Villous; Aged; Colonic Neoplasms; Colonoscopy; Diabe | 2006 |
Canadian Association of Radiologists: consensus guidelines for the prevention of contrast-induced nephropathy.
Topics: Acetylcysteine; Acute Kidney Injury; Adult; Aging; Child; Chronic Disease; Contrast Media; Drug Inte | 2007 |
Canadian Association of Radiologists: consensus guidelines for the prevention of contrast-induced nephropathy.
Topics: Acetylcysteine; Acute Kidney Injury; Adult; Aging; Child; Chronic Disease; Contrast Media; Drug Inte | 2007 |
Canadian Association of Radiologists: consensus guidelines for the prevention of contrast-induced nephropathy.
Topics: Acetylcysteine; Acute Kidney Injury; Adult; Aging; Child; Chronic Disease; Contrast Media; Drug Inte | 2007 |
Canadian Association of Radiologists: consensus guidelines for the prevention of contrast-induced nephropathy.
Topics: Acetylcysteine; Acute Kidney Injury; Adult; Aging; Child; Chronic Disease; Contrast Media; Drug Inte | 2007 |
A case of fatal intoxication from metformin.
Topics: Acidosis, Lactic; Acute Kidney Injury; Diabetes Mellitus, Type 2; Fatal Outcome; Female; Forensic To | 2007 |
[Metformin-associated lactic acidosis and acute renal failure secondary to cardiac catheterism].
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged, 80 and over; Cardiac Catheterization; Humans; Hypoglyce | 2007 |
[Overdose of metformin secondary to acute renal insufficiency: a report of six cases].
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic | 2007 |
Metformin-induced lactic acidosis and acute pancreatitis precipitated by diuretic, celecoxib, and candesartan-associated acute kidney dysfunction.
Topics: Acidosis, Lactic; Acute Disease; Acute Kidney Injury; Angiotensin II Type 1 Receptor Blockers; Benzi | 2008 |
[Metformin should not be used by patients with reduced renal function].
Topics: Acidosis, Lactic; Acute Kidney Injury; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Ag | 2008 |
New contraindication to intravascular iodinated contrast material.
Topics: Acidosis, Lactic; Acute Kidney Injury; Contraindications; Contrast Media; Diabetes Mellitus, Type 2; | 1995 |
New contraindication to intravascular iodinated contrast material.
Topics: Acidosis, Lactic; Acute Kidney Injury; Contraindications; Contrast Media; Diabetes Mellitus, Type 2; | 1995 |
[Withdraw metformin prior to contrast radiography. A warning in the Fass was forgotten, two patients died].
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Angiography; Anuria; Catalogs, Drug as Topic; Contrast | 1995 |
Metformin-associated lactic acidosis in diabetic patients with acute renal failure.
Topics: Acidosis, Lactic; Acute Kidney Injury; Animals; Diabetes Mellitus, Type 2; Diabetic Nephropathies; G | 1995 |
Metformin-associated lactic acidosis in diabetic patients with acute renal failure. A critical analysis of its pathogenesis and prognosis.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Eryt | 1994 |
New contraindication to intravascular contrast material.
Topics: Acidosis, Lactic; Acute Kidney Injury; Contraindications; Contrast Media; Humans; Hypoglycemic Agent | 1996 |
Intravascular injection of iodinated contrast media.
Topics: Acute Kidney Injury; Contraindications; Contrast Media; Drug Interactions; Humans; Hypoglycemic Agen | 1996 |
Metformin-induced lactic acidosis associated with acute renal failure.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Arteriosclerosis; Blood Urea Nitrogen; Contrast Media; | 1996 |
Metformin-associated nonketotic metabolic acidosis.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Diabetes Mellitus, Type 1; Humans; Hypoglycemic Agents; | 1997 |
Guidelines for performing angiography in patients taking metformin. Members of the Laboratory Performance Standards Committee of the Society for Cardiac Angiography and Interventions.
Topics: Acidosis, Lactic; Acute Kidney Injury; Angiography; Contrast Media; Humans; Hypoglycemic Agents; Iod | 1998 |
Non-steroidal anti-inflammatory drugs and metformin: a cause for concern?
Topics: Acidosis, Lactic; Acute Kidney Injury; Anti-Inflammatory Agents, Non-Steroidal; Back Pain; Diabetes | 1998 |
Non-steroidal anti-inflammatory drugs and metformin.
Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents, Non-Steroidal; Guinea Pigs; Hypoglycemic Age | 1998 |
Metformin hydrochloride all right before, but not after, contrast medium administration.
Topics: Acidosis, Lactic; Acute Kidney Injury; Contraindications; Contrast Media; Diabetes Mellitus, Type 2; | 1998 |
[Hemodialysis cured severe lactic acidosis caused by metformin treatment].
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Contraindications; Contrast Media; Diabetes Mellitus, T | 1999 |
Metformin retention independent of renal failure in intestinal occlusion.
Topics: Acute Kidney Injury; Aged; Animals; Blood Glucose; Cecum; Creatinine; Diabetes Mellitus, Type 2; Fem | 2001 |
Case of the month. Hepatic and renal failure in a patient taking troglitazone and metformin.
Topics: Acute Kidney Injury; Chromans; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Liver Failure | 2001 |
Metformin-associated lactic acidosis in a low risk patient.
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Contraindications; Female; Humans; Hypoglycemic Agents; | 2001 |
[Metformin-associated lactic acidosis with acute renal failure in type 2 diabetes mellitus].
Topics: Acidosis, Lactic; Acute Kidney Injury; Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Humans; K | 2002 |
Metformin-induced lactic acidosis in the presence of acute renal failure.
Topics: Acute Kidney Injury; Adult; Aged; Alanine; Blood Glucose; Creatinine; Diabetic Ketoacidosis; Female; | 1977 |
[Acute renal failure after intravenous urography in diabetics. Incidence of lactic acidosis in metformin treatment].
Topics: Acidosis; Acute Kidney Injury; Aged; Contrast Media; Diabetes Complications; Diabetes Mellitus; Fema | 1977 |
Lactic acidosis due to metformin therapy in a low risk patient.
Topics: Acidosis, Lactic; Acute Kidney Injury; Chlorpropamide; Diabetes Mellitus, Type 2; Female; Humans; Me | 1988 |
Metformin and lactic acidosis.
Topics: Acute Kidney Injury; Aged; Diabetes Mellitus; Diabetic Ketoacidosis; Female; Humans; Lactates; Metfo | 1972 |
The treatment of lactic acidosis in the diabetic patient by peritoneal dialysis using sodium acetate. A report of two cases.
Topics: Acetates; Acute Kidney Injury; Aged; Bicarbonates; Blood Glucose; Carbon Dioxide; Chlorides; Diabeti | 1974 |