metformin has been researched along with Acidosis in 70 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Acidosis: A pathologic condition of acid accumulation or depletion of base in the body. The two main types are RESPIRATORY ACIDOSIS and metabolic acidosis, due to metabolic acid build up.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin-associated lactic acidosis is a well-described and commonly encountered condition associated with significant morbidity and mortality." | 9.41 | Expanding the evidence for managing metformin poisoning to support decision-making. ( Ghannoum, M; Roberts, DM, 2023) |
| "Metformin-associated lactic acidosis is a well-known metformin treatment complication; however, the development of euglycemic diabetic ketoacidosis (euDKA) has rarely been reported." | 8.31 | Severe lactic acidosis with euglycemic diabetic ketoacidosis due to metformin overdose. ( Fujimaru, T; Hifumi, T; Ito, Y; Kadota, N; Konishi, K; Kuno, H; Nagahama, M; Nakayama, M; Otani, N; Sekiguchi, M; Taki, F; Watanabe, K, 2023) |
| " Metabolic acidosis in a patient with a history of metformin intake should suggest the possibility of metformin-associated lactic acidosis, which must be treated immediately, without waiting for the results of other examinations, especially in patients with sudden blindness." | 8.31 | Reversible acute blindness in suspected metformin-associated lactic acidosis: a case report. ( Huang, R; Sun, W, 2023) |
| "To investigate whether the use of metformin during computed tomography (CT) with radiocontrast agents increases the risk of contrast-induced nephropathy (CIN) and metabolic acidosis after CT in type 2 diabetes patients with mild to moderate renal failure." | 7.91 | Are patients with mild to moderate renal impairment on metformin or other oral anti-hyperglycaemic agents at increased risk of contrast-induced nephropathy and metabolic acidosis after radiocontrast exposure? ( Baek, JH; Cho, HS; Cho, YY; Hahm, JR; Jung, J; Jung, JH; Kim, HS; Kim, KY; Kim, SK, 2019) |
| "Most cases of metabolic and lactic acidosis in the hospital setting occur in patients not taking metformin." | 7.76 | Acidosis in the hospital setting: is metformin a common precipitant? ( Inder, WJ; Martin, JH; Scott, KA, 2010) |
| "Lactic acidosis is a well-recognized side effect of metformin, especially in patients with renal failure." | 7.71 | High anion gap metabolic acidosis in suicide: don't forget metformin intoxication--two patients' experiences. ( Chang, CT; Chen, YC; Fang, JT; Huang, CC, 2002) |
| "A 71 year old hypertensive, non insulin-dependent diabetic patient with moderate renal insufficiency taking 500 mg/d of metformin and 5 mg/d of enalapril, developed metabolic acidosis characterized by fairly elevated anion gap, hyperchloremia, severe hyperkaliemia, normal plasma level of 3-hydroxybutyric acid, absence of ketonuria and high plasma level of lactic acid." | 7.69 | Possible synergistic effect of metformin and enalapril on the development of hyperkaliemic lactic acidosis. ( Elisabetta, Z; Emanuela, M; Franzetti, I; Marco, G; Paolo, D; Renato, U, 1997) |
| "In recent years, lactic acidosis has been described in association with metformin therapy in diabetics." | 7.66 | Lactic acidosis during metformin treatment in an elderly diabetic patient with impaired renal function. ( Casey, C; Hermann, LS; Magnusson, S; Möller, B; Tucker, GT; Woods, HF, 1981) |
| "Although lactic acidosis has been recognized as a potential hazard in biguanide therapy, this complication has been claimed to be extremely rare with dimethylbiguanide (DMBG) (metformin)." | 7.66 | Metformin-induced lactic acidosis: potentiation by ethanol. ( Dubas, TC; Johnson, WJ, 1981) |
| "A case of lactic acidosis occurring in association with inappropriate and excessive metformin therapy and a high serum metformin concentration is described." | 7.66 | Metformin associated lactic acidosis. ( Clarkson, AR; Gilmore, HR; Phillips, PJ; Scicchitano, R, 1978) |
| "Canagliflozin is a novel drug for diabetes mellitus with the mechanisms of inducing glucosuria through inhibition of the sodium-glucose cotransporter 2 in the kidney independent of insulin activity." | 5.51 | Metabolic Acidosis in Postsurgical Patient on Canagliflozin and Metformin: A Case Report. ( Darwish, AM, 2019) |
| "Metformin-associated lactic acidosis is a well-described and commonly encountered condition associated with significant morbidity and mortality." | 5.41 | Expanding the evidence for managing metformin poisoning to support decision-making. ( Ghannoum, M; Roberts, DM, 2023) |
| "We performed a systematic search on PubMed, applying the following search terms: "acute metabolic acidosis," "lactic acidosis," "metformin" AND "acidosis," "unbalanced solutions" AND "acidosis," "bicarbonate" AND "acidosis" AND "outcome," "acute metabolic acidosis" AND "management," and "acute metabolic acidosis" AND "renal replacement therapy (RRT)/dialysis." | 5.05 | Etiology and Management of Acute Metabolic Acidosis: An Update. ( Matyukhin, I; Patschan, D; Patschan, S; Ritter, O, 2020) |
| " The primary outcomes were mortality, occurrence of lactic acidosis and myocardial infarction (MI) in patients taking metformin during dialysis treatment for ≥12 months (long term)." | 5.01 | Is the use of metformin in patients undergoing dialysis hazardous for life? A systematic review of the safety of metformin in patients undergoing dialysis. ( Abdel Shaheed, C; Carland, JE; Chowdhury, G; Day, RO; Furlong, T; Graham, GG; Greenfield, JR; Hicks, M; Macdonald, P; Smith, FC; Smith, G; Stocker, SL; Williams, KM, 2019) |
| "The paper presents an analysis of clinical symptoms, signs and laboratory data of 330 diabetic patients who developed lactic acidosis after having been treated with biguanides (phenformin, buformin, metformin)." | 4.75 | Lactic acidosis in biguanide-treated diabetics: a review of 330 cases. ( Eggstein, M; Luft, D; Schmülling, RM, 1978) |
| "Metformin-associated lactic acidosis is a well-known metformin treatment complication; however, the development of euglycemic diabetic ketoacidosis (euDKA) has rarely been reported." | 4.31 | Severe lactic acidosis with euglycemic diabetic ketoacidosis due to metformin overdose. ( Fujimaru, T; Hifumi, T; Ito, Y; Kadota, N; Konishi, K; Kuno, H; Nagahama, M; Nakayama, M; Otani, N; Sekiguchi, M; Taki, F; Watanabe, K, 2023) |
| " Metabolic acidosis in a patient with a history of metformin intake should suggest the possibility of metformin-associated lactic acidosis, which must be treated immediately, without waiting for the results of other examinations, especially in patients with sudden blindness." | 4.31 | Reversible acute blindness in suspected metformin-associated lactic acidosis: a case report. ( Huang, R; Sun, W, 2023) |
| "To investigate whether the use of metformin during computed tomography (CT) with radiocontrast agents increases the risk of contrast-induced nephropathy (CIN) and metabolic acidosis after CT in type 2 diabetes patients with mild to moderate renal failure." | 3.91 | Are patients with mild to moderate renal impairment on metformin or other oral anti-hyperglycaemic agents at increased risk of contrast-induced nephropathy and metabolic acidosis after radiocontrast exposure? ( Baek, JH; Cho, HS; Cho, YY; Hahm, JR; Jung, J; Jung, JH; Kim, HS; Kim, KY; Kim, SK, 2019) |
| "Massive metformin overdose can cause metabolic acidosis with hyperlactatemia." | 3.88 | 'Massive' metformin overdose. ( Chiew, AL; Dobos, NM; Isbister, GK; McArdle, K; Mostafa, AA; Newth, A; Roberts, MS; Wright, DFB, 2018) |
| "These data indicate the presence of a coexisting risk factor, other than metformin use, associated with metabolic acidosis after contrast medium exposure." | 3.83 | The association between use of metformin and change in serum CO2 level after administration of contrast medium. ( Baek, JH; Hahm, JR; Jung, J; Jung, JH; Kim, KY; Kim, SK, 2016) |
| "Most cases of metabolic and lactic acidosis in the hospital setting occur in patients not taking metformin." | 3.76 | Acidosis in the hospital setting: is metformin a common precipitant? ( Inder, WJ; Martin, JH; Scott, KA, 2010) |
| "A 39-year-old woman with type-2 diabetes mellitus presented with metabolic acidosis due to an attempted suicide with metformin." | 3.74 | [Fatal autointoxication with metformin]. ( Bijleveld, YA; de Pont, AC; Franssen, EJ; Hoekstra, JB; Jansen, ME; Kerver, ED, 2007) |
| "We report a case of severe metabolic acidosis associated with acute renal failure and septicaemia following treatment with maximal therapeutic doses of metformin and diclofenac." | 3.73 | Intensive care treatment of severe mixed metabolic acidosis. ( Akeson, J; Christensson, A; Schmidt, A, 2005) |
| "A 71 year old hypertensive, non insulin-dependent diabetic patient with moderate renal insufficiency taking 500 mg/d of metformin and 5 mg/d of enalapril, developed metabolic acidosis characterized by fairly elevated anion gap, hyperchloremia, severe hyperkaliemia, normal plasma level of 3-hydroxybutyric acid, absence of ketonuria and high plasma level of lactic acid." | 3.69 | Possible synergistic effect of metformin and enalapril on the development of hyperkaliemic lactic acidosis. ( Elisabetta, Z; Emanuela, M; Franzetti, I; Marco, G; Paolo, D; Renato, U, 1997) |
| " There were 42 cases of metformin-associated lactic acidosis (MALA) with 18 deaths (43%); 40 of the MALA cases had documented contra-indications, especially renal impairment, and the remaining two cases were due to drug overdosage, one being a suicide." | 3.67 | Metformin and the sulphonylureas: the comparative risk. ( Campbell, IW, 1985) |
| "During the 1970s two biguanide drugs, phenformin and metformin, were used to control hyperglycemia." | 3.66 | The status of metformin in Canada. ( Lucis, OJ, 1983) |
| "In recent years, lactic acidosis has been described in association with metformin therapy in diabetics." | 3.66 | Lactic acidosis during metformin treatment in an elderly diabetic patient with impaired renal function. ( Casey, C; Hermann, LS; Magnusson, S; Möller, B; Tucker, GT; Woods, HF, 1981) |
| "A case of lactic acidosis occurring in association with inappropriate and excessive metformin therapy and a high serum metformin concentration is described." | 3.66 | Metformin associated lactic acidosis. ( Clarkson, AR; Gilmore, HR; Phillips, PJ; Scicchitano, R, 1978) |
| "Although lactic acidosis has been recognized as a potential hazard in biguanide therapy, this complication has been claimed to be extremely rare with dimethylbiguanide (DMBG) (metformin)." | 3.66 | Metformin-induced lactic acidosis: potentiation by ethanol. ( Dubas, TC; Johnson, WJ, 1981) |
| " In Austria, the association of lactic acidosis with biguanide therapy has led to a cancellation of the registration of buformin and phenformin." | 3.66 | [Biguanides: reasons for withdrawal of drugs and remaining indications]. ( Bolzano, K, 1978) |
| "A survey of the literature leads to the conclusion that lactic acidosis should be considered as a side effect of therapy with biguanides." | 3.65 | [The importance of lactate acidosis as a side effect of biguanide therapy]. ( Förster, H, 1976) |
| "Poisoning is a common problem in the United States." | 2.82 | The Role of the Nephrologist in Management of Poisoning and Intoxication: Core Curriculum 2022. ( Kraut, JA; Mullins, ME, 2022) |
| "Canagliflozin is a novel drug for diabetes mellitus with the mechanisms of inducing glucosuria through inhibition of the sodium-glucose cotransporter 2 in the kidney independent of insulin activity." | 1.51 | Metabolic Acidosis in Postsurgical Patient on Canagliflozin and Metformin: A Case Report. ( Darwish, AM, 2019) |
| "Thirty (39%) patients suffered cardiac arrest before admission." | 1.43 | Prognosis of patients presenting extreme acidosis (pH <7) on admission to intensive care unit. ( Allou, N; Allyn, J; Brulliard, C; Combe, P; Galliot, R; Jabot, J; Martinet, O; Tabatchnik, X; Vandroux, D, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 41 (58.57) | 18.7374 |
| 1990's | 2 (2.86) | 18.2507 |
| 2000's | 6 (8.57) | 29.6817 |
| 2010's | 13 (18.57) | 24.3611 |
| 2020's | 8 (11.43) | 2.80 |
| Authors | Studies |
|---|---|
| Mullins, ME | 1 |
| Kraut, JA | 1 |
| Mehrpour, O | 1 |
| Saeedi, F | 1 |
| Hoyte, C | 1 |
| Hadianfar, A | 1 |
| Nakhaee, S | 1 |
| Brent, J | 1 |
| Kuno, H | 1 |
| Fujimaru, T | 1 |
| Kadota, N | 1 |
| Konishi, K | 1 |
| Sekiguchi, M | 1 |
| Watanabe, K | 1 |
| Ito, Y | 1 |
| Nagahama, M | 1 |
| Taki, F | 1 |
| Hifumi, T | 1 |
| Otani, N | 1 |
| Nakayama, M | 1 |
| Roberts, DM | 1 |
| Ghannoum, M | 1 |
| Huang, R | 1 |
| Sun, W | 1 |
| Abdel Shaheed, C | 1 |
| Carland, JE | 1 |
| Graham, GG | 1 |
| Stocker, SL | 1 |
| Smith, G | 1 |
| Hicks, M | 1 |
| Williams, KM | 1 |
| Furlong, T | 1 |
| Macdonald, P | 1 |
| Greenfield, JR | 1 |
| Smith, FC | 1 |
| Chowdhury, G | 1 |
| Day, RO | 1 |
| Matyukhin, I | 1 |
| Patschan, S | 1 |
| Ritter, O | 1 |
| Patschan, D | 1 |
| Cheng, X | 1 |
| Liu, YM | 1 |
| Li, H | 2 |
| Zhang, X | 1 |
| Lei, F | 1 |
| Qin, JJ | 1 |
| Chen, Z | 1 |
| Deng, KQ | 1 |
| Lin, L | 1 |
| Chen, MM | 1 |
| Song, X | 1 |
| Xia, M | 1 |
| Huang, X | 2 |
| Liu, W | 1 |
| Cai, J | 1 |
| Zhang, XJ | 1 |
| Zhou, F | 1 |
| Zhang, P | 1 |
| Wang, Y | 1 |
| Ma, X | 1 |
| Xu, Q | 1 |
| Yang, J | 1 |
| Ye, P | 1 |
| Mao, W | 1 |
| Xia, J | 1 |
| Zhang, BH | 1 |
| Guo, J | 1 |
| Zhu, L | 1 |
| Lu, Z | 1 |
| Yuan, Y | 1 |
| Wei, X | 1 |
| She, ZG | 1 |
| Ji, YX | 1 |
| Lui, DTW | 1 |
| Tan, KCB | 1 |
| Chiew, AL | 1 |
| Wright, DFB | 1 |
| Dobos, NM | 1 |
| McArdle, K | 1 |
| Mostafa, AA | 1 |
| Newth, A | 1 |
| Roberts, MS | 1 |
| Isbister, GK | 1 |
| Darwish, AM | 1 |
| Leung, AA | 1 |
| Padwal, RS | 1 |
| Krüger, HJ | 1 |
| De Wet, R | 1 |
| Blumberg, LH | 1 |
| Weyer, J | 1 |
| Lemke, FG | 1 |
| Jung, J | 2 |
| Cho, YY | 1 |
| Jung, JH | 2 |
| Kim, KY | 2 |
| Kim, HS | 1 |
| Baek, JH | 2 |
| Hahm, JR | 2 |
| Cho, HS | 1 |
| Kim, SK | 2 |
| Acharya, AP | 1 |
| Rafi, M | 1 |
| Woods, EC | 1 |
| Gardner, AB | 1 |
| Murthy, N | 1 |
| Graham, RE | 1 |
| Cartner, M | 1 |
| Winearls, J | 1 |
| Allyn, J | 1 |
| Vandroux, D | 1 |
| Jabot, J | 1 |
| Brulliard, C | 1 |
| Galliot, R | 1 |
| Tabatchnik, X | 1 |
| Combe, P | 1 |
| Martinet, O | 1 |
| Allou, N | 1 |
| Kuo, CC | 1 |
| Yeh, HC | 1 |
| Chen, B | 1 |
| Tsai, CW | 1 |
| Lin, YS | 1 |
| Huang, CC | 2 |
| Ebrahim, I | 1 |
| Blockman, M | 1 |
| Chang, LC | 1 |
| Hung, SC | 1 |
| Yang, CS | 1 |
| Scott, KA | 1 |
| Martin, JH | 1 |
| Inder, WJ | 1 |
| Chang, CT | 1 |
| Chen, YC | 1 |
| Fang, JT | 1 |
| Schmidt, A | 1 |
| Christensson, A | 1 |
| Akeson, J | 1 |
| de Pont, AC | 1 |
| Kerver, ED | 1 |
| Jansen, ME | 1 |
| Bijleveld, YA | 1 |
| Franssen, EJ | 1 |
| Hoekstra, JB | 1 |
| Aquarius, M | 1 |
| van Kuijk, WH | 1 |
| Lalau, JD | 1 |
| Debussche, X | 1 |
| Tolani, M | 1 |
| Arlot, S | 1 |
| Quichaud, J | 1 |
| Kühnau, J | 1 |
| Campbell, IW | 2 |
| Chalopin, JM | 1 |
| Tanter, Y | 1 |
| Besancenot, JF | 1 |
| Cabanne, JF | 1 |
| Rifle, G | 1 |
| Ryder, RE | 1 |
| Lucis, OJ | 1 |
| Biron, P | 3 |
| Guérin, JM | 1 |
| Raux, M | 1 |
| Segrestaa, JM | 1 |
| Lamotte, M | 1 |
| Hermann, LS | 1 |
| Magnusson, S | 1 |
| Möller, B | 1 |
| Casey, C | 1 |
| Tucker, GT | 1 |
| Woods, HF | 1 |
| Dubas, TC | 1 |
| Johnson, WJ | 1 |
| Capretti, L | 1 |
| Fici, F | 1 |
| Coscelli, C | 1 |
| Butturini, U | 1 |
| Franzetti, I | 1 |
| Paolo, D | 1 |
| Marco, G | 1 |
| Emanuela, M | 1 |
| Elisabetta, Z | 1 |
| Renato, U | 1 |
| Darwich, MS | 1 |
| Allaf, W | 1 |
| Kotler, DP | 1 |
| Hazard, J | 1 |
| Phillips, PJ | 3 |
| Scicchitano, R | 1 |
| Clarkson, AR | 1 |
| Gilmore, HR | 1 |
| Luft, D | 1 |
| Schmülling, RM | 1 |
| Eggstein, M | 1 |
| Korhonen, T | 2 |
| Idänpään-Heikkilä, J | 2 |
| Aro, A | 3 |
| Irsigler, K | 1 |
| Kritz, H | 1 |
| Regal, H | 1 |
| Foltin, E | 1 |
| Bergman, U | 1 |
| Boman, G | 1 |
| Wiholm, BE | 1 |
| Kimbel, KH | 1 |
| Charbonnel, B | 1 |
| Peltier, P | 1 |
| Ozanne, P | 1 |
| Chupin, M | 1 |
| Beutter, D | 1 |
| Dieterle, C | 1 |
| Bolzano, K | 1 |
| Thomas, DW | 1 |
| Harding, PE | 1 |
| Prinseau, J | 1 |
| Jardin, F | 1 |
| Sanchez, A | 1 |
| Baglin, A | 1 |
| Domart, M | 1 |
| Lubetzki, J | 1 |
| Margairaz, A | 1 |
| Fritel, D | 1 |
| Hunt, JA | 1 |
| Catellier, C | 1 |
| Dupre, J | 1 |
| Gardiner, RJ | 1 |
| McKendry, JB | 1 |
| Toews, CJ | 1 |
| Yip, CC | 1 |
| Förster, H | 1 |
| Berger, W | 1 |
| Mehnert-Aner, S | 1 |
| Mülly, K | 1 |
| Heierli, C | 1 |
| Ritz, R | 1 |
| Bismuth, C | 1 |
| Gaultier, M | 1 |
| Conso, F | 1 |
| Heuclin, C | 1 |
| Assan, R | 1 |
| Perrot, D | 1 |
| Claris, O | 1 |
| Guillaume, C | 1 |
| Bouffard, Y | 1 |
| Delafosse, B | 1 |
| Motin, J | 1 |
| Harding, AP | 1 |
| Walker, RS | 1 |
| Tomkins, AM | 1 |
| Jones, R | 1 |
| Bloom, A | 1 |
| Harris, EL | 1 |
| Pyke, DA | 1 |
| Stowers, JM | 1 |
| Smith, OA | 1 |
5 reviews available for metformin and Acidosis
| Article | Year |
|---|---|
The Role of the Nephrologist in Management of Poisoning and Intoxication: Core Curriculum 2022.
Topics: Acidosis; Curriculum; Drug Overdose; Humans; Metformin; Nephrologists; Poisoning | 2022 |
Expanding the evidence for managing metformin poisoning to support decision-making.
Topics: Acidosis; Acidosis, Lactic; Drug Overdose; Humans; Hypoglycemic Agents; Metformin; Poisoning; Renal | 2023 |
Is the use of metformin in patients undergoing dialysis hazardous for life? A systematic review of the safety of metformin in patients undergoing dialysis.
Topics: Acidosis; Diabetes Mellitus, Type 2; Drug Monitoring; Humans; Hypoglycemic Agents; Kidney; Kidney Di | 2019 |
Etiology and Management of Acute Metabolic Acidosis: An Update.
Topics: Acidosis; Acidosis, Lactic; Acute Disease; Animals; Bicarbonates; Disease Management; Electrolytes; | 2020 |
Lactic acidosis in biguanide-treated diabetics: a review of 330 cases.
Topics: Acidosis; Biguanides; Buformin; Diabetes Complications; Diabetes Mellitus; Humans; Hypoglycemic Agen | 1978 |
1 trial available for metformin and Acidosis
| Article | Year |
|---|---|
[The risk of lacticate acidosis: a comparison of the 3 biguanides in treatment of diabetics (authors' transl)].
Topics: Acidosis; Biguanides; Buformin; Diabetes Mellitus; Exercise Test; Female; Humans; Lactates; Male; Me | 1978 |
64 other studies available for metformin and Acidosis
| Article | Year |
|---|---|
Distinguishing characteristics of exposure to biguanide and sulfonylurea anti-diabetic medications in the United States.
Topics: Abdominal Pain; Acidosis; Adolescent; Adult; Aged; Child; Creatinine; Diabetes Mellitus; Diarrhea; D | 2022 |
Severe lactic acidosis with euglycemic diabetic ketoacidosis due to metformin overdose.
Topics: Acidosis; Acidosis, Lactic; Diabetes Mellitus, Type 2; Diabetic Ketoacidosis; Female; Humans; Ketone | 2023 |
Reversible acute blindness in suspected metformin-associated lactic acidosis: a case report.
Topics: Acidosis; Acidosis, Lactic; Acute Kidney Injury; Blindness; Diabetes Mellitus, Type 2; Female; Human | 2023 |
Metformin Is Associated with Higher Incidence of Acidosis, but Not Mortality, in Individuals with COVID-19 and Pre-existing Type 2 Diabetes.
Topics: Acidosis; Acidosis, Lactic; Aged; China; Coronavirus Infections; COVID-19; Diabetes Mellitus, Type 2 | 2020 |
Is metformin a miracle or a menace in COVID-19 patients with type 2 diabetes?
Topics: Acidosis; COVID-19; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Incidence; Metformin; SA | 2021 |
'Massive' metformin overdose.
Topics: Acidosis; Drug Overdose; Female; Hemodiafiltration; Humans; Hypoglycemic Agents; Metformin; Middle A | 2018 |
Metabolic Acidosis in Postsurgical Patient on Canagliflozin and Metformin: A Case Report.
Topics: Acidosis; Adult; Canagliflozin; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hypogl | 2019 |
Metformin use was linked to hospitalization for acidosis at 6 y only in patients with eGFR < 30 mL/min/1.73 m2.
Topics: Acidosis; Acidosis, Lactic; Cohort Studies; ErbB Receptors; Hospitalization; Humans; Hypoglycemic Ag | 2018 |
Atypical presentation of Crimean-Congo haemorrhagic fever: Lessons learned.
Topics: Acidosis; Comorbidity; Diabetes Mellitus, Type 2; Diabetic Ketoacidosis; Diagnosis, Differential; Dr | 2019 |
Are patients with mild to moderate renal impairment on metformin or other oral anti-hyperglycaemic agents at increased risk of contrast-induced nephropathy and metabolic acidosis after radiocontrast exposure?
Topics: Acidosis; Administration, Oral; Aged; Contrast Media; Diabetes Mellitus, Type 2; Female; Humans; Hyp | 2019 |
Metabolic engineering of lactate dehydrogenase rescues mice from acidosis.
Topics: Acidosis; Animals; Boronic Acids; Cells, Cultured; Female; Hypoglycemic Agents; Kinetics; L-Lactate | 2014 |
A severe case of vasoplegic shock following metformin overdose successfully treated with methylene blue as a last line therapy.
Topics: Acidosis; Adult; Drug Overdose; Fluid Therapy; Gliclazide; Humans; Male; Metformin; Methylene Blue; | 2015 |
Prognosis of patients presenting extreme acidosis (pH <7) on admission to intensive care unit.
Topics: Acidosis; Acidosis, Lactic; Acidosis, Respiratory; Adult; Aged; Diabetes Mellitus; Extracorporeal Me | 2016 |
Prevalence of Metformin Use and the Associated Risk of Metabolic Acidosis in US Diabetic Adults With CKD: A National Cross-Sectional Study.
Topics: Acidosis; Adult; Aged; Bicarbonates; Chlorides; Cross-Sectional Studies; Diabetes Mellitus; Diet; Fe | 2015 |
The association between use of metformin and change in serum CO2 level after administration of contrast medium.
Topics: Acidosis; Administration, Oral; Aged; Carbon Dioxide; Comorbidity; Contrast Media; Creatinine; Dose- | 2016 |
Metabolic acidosis in a patient with metformin overdose.
Topics: Acidosis; Blood Gas Analysis; Cardiotonic Agents; Drug Overdose; Fatal Outcome; Female; Heart Arrest | 2017 |
The case. A suicidal woman with delayed high anion gap metabolic acidosis.
Topics: Acidosis; Diabetes Mellitus, Type 2; Drug Overdose; Female; Humans; Metformin; Middle Aged; Pyridine | 2009 |
Acidosis in the hospital setting: is metformin a common precipitant?
Topics: Acidosis; Adult; Aged; Aged, 80 and over; Female; Hospital Mortality; Hospitalization; Humans; Male; | 2010 |
High anion gap metabolic acidosis in suicide: don't forget metformin intoxication--two patients' experiences.
Topics: Acid-Base Equilibrium; Acidosis; Adult; Female; Humans; Hypoglycemic Agents; Metformin; Middle Aged; | 2002 |
Intensive care treatment of severe mixed metabolic acidosis.
Topics: Abdominal Abscess; Acidosis; Acute Kidney Injury; Aged; Anti-Inflammatory Agents, Non-Steroidal; Blo | 2005 |
[Fatal autointoxication with metformin].
Topics: Acidosis; Adult; Diabetes Mellitus, Type 2; Drug Overdose; Fatal Outcome; Female; Humans; Hypoglycem | 2007 |
[Fatal autointoxication with metformin].
Topics: Acidosis; Female; Humans; Hypoglycemic Agents; Metformin; Multiple Organ Failure | 2007 |
[Lactic acidosis in diabetic patients treated with metformin. Value of hemodialysis with a sodium bicarbonate bath].
Topics: Acidosis; Aged; Bicarbonates; Diabetes Mellitus, Type 2; Humans; Lactates; Male; Metformin; Middle A | 1984 |
[Metformin in combination therapy of diabetes mellitus. Advantages and reservations].
Topics: Acidosis; Chemical and Drug Induced Liver Injury; Diabetes Mellitus; Drug Therapy, Combination; Huma | 1983 |
Metformin and glibenclamide: comparative risks.
Topics: Acidosis; Aged; Diabetes Mellitus, Type 2; Glyburide; Humans; Hypoglycemia; Lactates; Metformin; Ris | 1984 |
Treatment of metformin-associated lactic acidosis with closed recirculation bicarbonate-buffered hemodialysis.
Topics: Acidosis; Bicarbonates; Buffers; Female; Humans; Lactates; Metformin; Middle Aged; Renal Dialysis | 1984 |
Lactic acidotic coma with multiple medication including metformin in a patient with normal renal function.
Topics: Acidosis; Adult; Diabetes Mellitus; Humans; Lactates; Male; Metformin | 1984 |
The status of metformin in Canada.
Topics: Acidosis; Canada; Humans; Hyperglycemia; Kinetics; Lactates; Metformin; Risk | 1983 |
[Surveillance of metformin: final report].
Topics: Acidosis; Canada; Diabetes Mellitus; Humans; Lactates; Metformin | 1981 |
[Lactic acidosis associated with metformin treatment. Discussion of the responsibility of the drug].
Topics: Acidosis; Aged; Female; Humans; Lactates; Male; Metformin; Middle Aged | 1980 |
Lactic acidosis during metformin treatment in an elderly diabetic patient with impaired renal function.
Topics: Acidosis; Aged; Diabetes Mellitus; Diabetic Nephropathies; Digitoxin; Female; Humans; Kidney Failure | 1981 |
Metformin-induced lactic acidosis: potentiation by ethanol.
Topics: Acidosis; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Drug Synergism; Ethanol; Fasting; | 1981 |
Pyridoxine-alpha-ketoglutarate in the treatment of experimental lactic acidosis in the rat.
Topics: Acidosis; Animals; Blood Glucose; Lactates; Male; Metformin; Pyridoxine; Rats | 1981 |
Metformin monitoring.
Topics: Acidosis; Canada; Diabetes Mellitus; Humans; Lactates; Metformin; Population Surveillance | 1980 |
Possible synergistic effect of metformin and enalapril on the development of hyperkaliemic lactic acidosis.
Topics: Acidosis; Aged; Antihypertensive Agents; Chlorides; Diabetes Mellitus, Type 2; Drug Synergism; Drug | 1997 |
Metabolic acidosis.
Topics: Acidosis; Female; Humans; Hypoglycemic Agents; Kidney Failure, Chronic; Metformin; Middle Aged | 1998 |
Metabolic alterations in HIV lipodystrophy. IAPAC sessions 2001, July 18-19, 2001 - Chicago.
Topics: Acidosis; Anti-HIV Agents; Bone Diseases, Metabolic; Cost-Benefit Analysis; Glucose; Glucose Intoler | 2001 |
[What is the role of the biguanides in the treatment of diabetes mellitus?].
Topics: Acidosis; Diabetes Mellitus; Drug Evaluation; Gastrointestinal Diseases; Humans; Lactates; Metformin | 1978 |
Metformin associated lactic acidosis.
Topics: Acidosis; Female; Humans; Lactates; Metformin; Middle Aged | 1978 |
Biguanide-induced lactic acidosis in Finland.
Topics: Acidosis; Aged; Biguanides; Finland; Humans; Hypoglycemic Agents; Lactates; Metformin; Middle Aged; | 1979 |
Biguanides and lactic acidosis in diabetics.
Topics: Acidosis; Diabetes Mellitus; Humans; Lactates; Metformin; Phenformin | 1977 |
Biguanides and lactic acidosis in diabetics.
Topics: Acidosis; Humans; Lactates; Metformin; Phenformin | 1978 |
Metformin monitoring.
Topics: Acidosis; Diabetes Mellitus; Humans; Lactates; Metformin | 1978 |
[Biguanides and lactic acidosis].
Topics: Acidosis; Biguanides; Buformin; Humans; Lactates; Metformin; Phenformin | 1978 |
Epidemiology of adverse drug reactions to phenformin and metformin.
Topics: Acidosis; Adolescent; Adult; Aged; Drug Prescriptions; Epidemiologic Methods; Female; Humans; Male; | 1978 |
[Biguanides].
Topics: Acidosis; Biguanides; Buformin; Humans; Metformin; Phenformin | 1978 |
[Severe lactic acidosis during acute alcoholic intoxication in a patient without kidney failure treated with metformin].
Topics: Acidosis; Adult; Alcoholic Intoxication; Diabetes Mellitus; Drug Synergism; Humans; Lactates; Male; | 1978 |
[Therapy of diabetes mellitus with oral drugs].
Topics: Acidosis; Body Weight; Diabetes Mellitus; Drug Tolerance; Humans; Metformin; Obesity; Sulfonylurea C | 1978 |
[Lactic acidosis associated with biguanide therapy in Finland 1974-1977].
Topics: Acidosis; Adult; Aged; Female; Humans; Lactates; Male; Metformin; Phenformin | 1978 |
[Biguanides: reasons for withdrawal of drugs and remaining indications].
Topics: Acidosis; Austria; Biguanides; Buformin; Diabetes Mellitus; Humans; Lactates; Legislation, Drug; Met | 1978 |
Oral hypoglycaemic agents--dangers and contraindications.
Topics: Acidosis; Humans; Lactates; Metformin; Phenformin | 1977 |
[Acute renal failure after intravenous urography in diabetics. Incidence of lactic acidosis in metformin treatment].
Topics: Acidosis; Acute Kidney Injury; Aged; Contrast Media; Diabetes Complications; Diabetes Mellitus; Fema | 1977 |
The use of phenformin and metformin.
Topics: Acidosis; Humans; Metformin; Phenformin; Risk | 1977 |
[The importance of lactate acidosis as a side effect of biguanide therapy].
Topics: Acidosis; Biguanides; Buformin; Diabetes Mellitus; Drug Therapy, Combination; Ethanol; Humans; Kidne | 1976 |
[10 cases of lactic acidosis during biguanide therapy (buformin and phenformin)].
Topics: Acidosis; Biguanides; Buformin; Diabetes Mellitus; Glucagon; Humans; Lactates; Liver; Metformin; Phe | 1976 |
[Lactic acidosis induced by excessive ingestion of metformin].
Topics: Acidosis; Adult; Diabetes Mellitus; Humans; Lactates; Male; Metformin | 1976 |
[Metformin and lactic acidosis: value of initial plasma assay of metformin and hemodialysis].
Topics: Acidosis; Humans; Lactates; Metformin; Renal Dialysis | 1986 |
Metformin and the sulphonylureas: the comparative risk.
Topics: Acidosis; Diabetes Mellitus, Type 2; Drug Interactions; Glyburide; Humans; Hypoglycemia; Metformin; | 1985 |
Letter: Lactic acidosis and biguanides.
Topics: Acidosis; Humans; Lactates; Metformin; Phenformin | 1974 |
Lactic acidosis through medicaments.
Topics: Acetates; Acidosis; Animals; Culture Techniques; Diabetes Mellitus; Diabetic Ketoacidosis; Female; G | 1970 |
Lactic acidosis occurring during phenformin therapy.
Topics: Acidosis; Diabetes Mellitus; Female; Humans; Lactates; Metformin; Middle Aged; Phenformin | 1972 |
Adverse reactions to oral antidiabetic agents.
Topics: Acetohexamide; Acidosis; Administration, Oral; Anemia; Chlorpropamide; Drug Antagonism; Drug Synergi | 1971 |
General treatment of diabetes.
Topics: Acidosis; Diabetes Mellitus; Diabetic Coma; Diabetic Nephropathies; Diabetic Retinopathy; Diet, Diab | 1970 |
Vitamin B 12 and metformin.
Topics: Acidosis; Diabetes Mellitus; Folic Acid; Humans; Intestinal Absorption; Lactates; Metformin; Phenfor | 1971 |