Page last updated: 2024-10-30

metformin and Acidosis, Diabetic

metformin has been researched along with Acidosis, Diabetic in 47 studies

Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.

Research Excerpts

ExcerptRelevanceReference
"Metformin-associated lactic acidosis is a well-known metformin treatment complication; however, the development of euglycemic diabetic ketoacidosis (euDKA) has rarely been reported."8.31Severe lactic acidosis with euglycemic diabetic ketoacidosis due to metformin overdose. ( Fujimaru, T; Hifumi, T; Ito, Y; Kadota, N; Konishi, K; Kuno, H; Nagahama, M; Nakayama, M; Otani, N; Sekiguchi, M; Taki, F; Watanabe, K, 2023)
"The patient was diagnosed with eu-DKA accompanied by severe hypernatremia (corrected serum Na concentration, 163 mEq/L) and hypokalemia following dapagliflozin re-administration."7.96Dapagliflozin-associated euglycemic diabetic ketoacidosis in a patient with type 2 diabetes mellitus: A case report. ( Ahn, DJ; Lee, IH, 2020)
"This was the first episode of diabetic ketoacidosis (DKA) for this patient."5.46Euglycemic Diabetic Ketoacidosis with Elevated Acetone in a Patient Taking a Sodium-Glucose Cotransporter-2 (SGLT2) Inhibitor. ( Andrews, TJ; Cox, RD; Kolb, J; Parker, C, 2017)
" Metformin and SGLT2 inhibitors should be discontinued in patients with severe forms of COVID-19 owing to the risks of lactic acidosis and ketoacidosis."5.05COVID-19 in diabetic patients: Related risks and specifics of management. ( Hermans, MP; Maiter, D; Orioli, L; Thissen, JP; Vandeleene, B; Yombi, JC, 2020)
"Metformin-associated lactic acidosis is a well-known metformin treatment complication; however, the development of euglycemic diabetic ketoacidosis (euDKA) has rarely been reported."4.31Severe lactic acidosis with euglycemic diabetic ketoacidosis due to metformin overdose. ( Fujimaru, T; Hifumi, T; Ito, Y; Kadota, N; Konishi, K; Kuno, H; Nagahama, M; Nakayama, M; Otani, N; Sekiguchi, M; Taki, F; Watanabe, K, 2023)
" The diagnosis leaned toward latent autoimmune diabetes in adults, and the therapeutic approach involved cessation of preprandial insulin therapy, regulation, and subsequent discontinuation of basal insulin and introduction of metformin."4.12Diabetic ketoacidosis as first presentation of latent autoimmune diabetes in adults in a patient with hashitoxicosis as first presentation of Hashimoto's thyroiditis: a case report. ( Fousteris, E; Lygnos, D; Xenou, M; Zoupas, I, 2022)
"The patient was diagnosed with eu-DKA accompanied by severe hypernatremia (corrected serum Na concentration, 163 mEq/L) and hypokalemia following dapagliflozin re-administration."3.96Dapagliflozin-associated euglycemic diabetic ketoacidosis in a patient with type 2 diabetes mellitus: A case report. ( Ahn, DJ; Lee, IH, 2020)
"Treatment with metformin is occasionally associated with the development of severe lactic acidosis."3.69Contraindications to metformin therapy in patients with NIDDM. ( Bosman, D; Krentz, AJ; Sulkin, TV, 1997)
"85 g metformin daily for 75 days, urinary retention caused by a prostatic adenoma induced functional renal insufficiency and hyperlactacidemia, rapidly reversed with treatment."3.66[Reversible lactic acidosis in a diabetic on high dose metformin (author's transl)]. ( Beaudot, C; Brohon, J; Lavieuville, M; Merceron, RE; Noël, M; Raymond, JP, 1980)
"The prevalence of type 2 diabetes mellitus (T2D) has risen in the United States and worldwide, with an increase in global prevalence from 4."2.61SGLT2 inhibitors and metformin: Dual antihyperglycemic therapy and the risk of metabolic acidosis in type 2 diabetes. ( Donnan, K; Segar, L, 2019)
"Five of the patients had pre-existing type 2 diabetes mellitus (DM)."1.72COVID-19 and diabetic ketoacidosis: A case series at an urban district hospital in South Africa. ( Dicks, HN; Naidoo, K, 2022)
"To compare the incidence of diabetic ketoacidosis (DKA) among patients with type 2 diabetes mellitus (T2DM) who were new users of sodium glucose co-transporter 2 inhibitors (SGLT2i) versus other classes of antihyperglycemic agents (AHAs)."1.51Diabetic ketoacidosis in patients with type 2 diabetes treated with sodium glucose co-transporter 2 inhibitors versus other antihyperglycemic agents: An observational study of four US administrative claims databases. ( Alba, M; Berlin, JA; DeFalco, F; Freedman, A; Hester, L; Lind, J; Meininger, G; Rosenthal, N; Ryan, PB; Schuemie, MJ; Sun, D; Voss, EA; Wang, L; Weaver, J; Yuan, Z, 2019)
"Severe hypertriglyceridemia was considered to have been a consequence of impaired insulin action and his apolipoprotein E4/2 phenotype."1.51Eruptive xanthomas in a patient with soft-drink diabetic ketosis and apolipoprotein E4/2. ( Aiba, S; Imai, J; Katagiri, H; Kikuchi, K; Kohata, M; Kurosawa, S; Nakajima, T; Satake, C; Sawada, S; Takahashi, K; Takeda, K; Tsuchiya, S, 2019)
"Diabetic ketoacidosis has been described as a rare complication of acromegaly and may be observed in 1% of affected patients."1.46Rapid Onset of Diabetic Ketoacidosis After SGLT2 Inhibition in a Patient With Unrecognized Acromegaly. ( Bilz, S; Brändle, M; Fournier, JY; Quarella, M; Walser, D, 2017)
"The insulin-induced edema is a rare complication of insulin therapy."1.46Insulin-induced edema: an unusual complication in a patient with diabetic ketosis. ( Chaker, F; Chihaoui, M; Rached, A; Slimane, H; Yazid, M, 2017)
"This was the first episode of diabetic ketoacidosis (DKA) for this patient."1.46Euglycemic Diabetic Ketoacidosis with Elevated Acetone in a Patient Taking a Sodium-Glucose Cotransporter-2 (SGLT2) Inhibitor. ( Andrews, TJ; Cox, RD; Kolb, J; Parker, C, 2017)
"Type 2 diabetes can present as diabetic ketoacidosis in obese adolescent subjects."1.32Type 2 diabetes presenting as diabetic ketoacidosis in adolescence. ( Cox, J; Elkeles, RS; Elwig, C; Poulter, C; Valabhji, J; Watson, M, 2003)

Research

Studies (47)

TimeframeStudies, this research(%)All Research%
pre-199016 (34.04)18.7374
1990's4 (8.51)18.2507
2000's4 (8.51)29.6817
2010's13 (27.66)24.3611
2020's10 (21.28)2.80

Authors

AuthorsStudies
Shamchuk, A1
Doulla, M1
Jetha, M1
Xenou, M1
Zoupas, I1
Lygnos, D1
Fousteris, E1
Dicks, HN1
Naidoo, K1
Kuno, H1
Fujimaru, T1
Kadota, N1
Konishi, K1
Sekiguchi, M1
Watanabe, K1
Ito, Y1
Nagahama, M1
Taki, F1
Hifumi, T1
Otani, N1
Nakayama, M1
Wang, L1
Voss, EA1
Weaver, J1
Hester, L1
Yuan, Z1
DeFalco, F1
Schuemie, MJ1
Ryan, PB1
Sun, D1
Freedman, A1
Alba, M1
Lind, J1
Meininger, G1
Berlin, JA1
Rosenthal, N1
Orioli, L1
Hermans, MP1
Thissen, JP1
Maiter, D1
Vandeleene, B1
Yombi, JC1
Lee, IH1
Ahn, DJ1
Koufakis, T1
Metallidis, S1
Zebekakis, P1
Ajjan, RA1
Kotsa, K1
Pauchet, A1
Schwotzer, N1
Lamine, F1
Perrottet, N1
Zanchi, A1
Golshayan, D1
Wojtusciszyn, A1
Chee, YJ1
Tan, SK1
Yeoh, E1
Azapagasi, E1
Yazici, MU1
Korucu, A1
Sarigul, B1
Bozkurt, I1
Tasar, M1
Elmaogullari, S1
Emeksiz, S1
Öcgüder, DA1
Quarella, M1
Walser, D1
Brändle, M1
Fournier, JY1
Bilz, S1
Mesmar, B1
Poola-Kella, S1
Malek, R1
Chaker, F1
Yazid, M1
Chihaoui, M1
Rached, A1
Slimane, H1
Tsuchiya, S1
Sawada, S1
Takeda, K1
Takahashi, K1
Nakajima, T1
Kohata, M1
Kurosawa, S1
Satake, C1
Imai, J1
Kikuchi, K1
Aiba, S1
Katagiri, H1
Donnan, K1
Segar, L1
Krüger, HJ1
De Wet, R1
Blumberg, LH1
Weyer, J1
Lemke, FG1
Mathuram Thiyagarajan, U1
Ponnuswamy, A1
Chung, A1
Kuo, SF1
Chuang, WY1
Ng, S1
Chen, CH1
Chang, CN1
Chou, CH1
Weng, WC1
Yeh, CH1
Lin, JD1
Rashid, O1
Farooq, S1
Kiran, Z1
Islam, N1
Valek, R1
Von der Mark, J1
Vellanki, P1
Smiley, DD1
Stefanovski, D1
Anzola, I1
Duan, W1
Hudson, M1
Peng, L1
Pasquel, FJ1
Umpierrez, GE1
Andrews, TJ1
Cox, RD1
Parker, C1
Kolb, J1
Heine, RJ1
Valabhji, J1
Watson, M1
Cox, J1
Poulter, C1
Elwig, C1
Elkeles, RS1
Bhasin, DK1
Sidhu, RS1
Bhansali, A1
Nagi, B1
Lunetta, M1
Presti, C1
Mughini, MT1
Mughini, L1
Beaudot, C1
Merceron, RE1
Lavieuville, M1
Noël, M1
Brohon, J1
Raymond, JP1
Pond, GD1
Smyth, SH1
Roach, DJ1
Hunter, G1
Pepper, GM1
Schwartz, M1
Sulkin, TV1
Bosman, D1
Krentz, AJ1
Pinhas-Hamiel, O1
Zeitler, P1
Lalau, JD2
Race, JM1
Alexander, WD1
Marples, J1
Assan, R1
Heuclin, C1
Ganeval, D1
Bismuth, C1
George, J1
Girard, JR1
Clarke, BF2
Campbell, IW1
Mirouze, J1
Mion, C1
Beraud, JJ1
Selam, JL1
Andrejak, M1
Morinière, P1
Coevoet, B1
Debussche, X1
Westeel, PF1
Fournier, A1
Quichaud, J1
Lambert, H1
Isnard, F1
Delorme, N1
Claude, D1
Bollaert, PE1
Straczek, J1
Larcan, A1
Yang, DP1
Liang, JZ1
Luo, ZT1
Lebacq, EG1
Tirzmalis, A1
Uvnäs, B1
Hayat, JC1
Duwoos, H1
Bertrand, CM1
Husson, A1
Cramer, J1
Tayot, J1
Debry, G1
Laurent, J1
Walker, RS1
Duncan, LJ1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Ketosis-Prone Diabetes in African Americans: Predictive Markers, Underlying Mechanisms, and Treatment Outcomes: The Effects of Metformin vs. Sitagliptin on Beta-Cell Preservation in Obese Subjects With Ketosis-Prone Type 2 Diabetes Mellitus[NCT01099618]Phase 448 participants (Actual)Interventional2010-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Length of Remission

For those patients that are able to discontinue insulin therapy at or <12 weeks, how long were they able to well controlled with an A1c <7% on the agent that they were randomized to. (NCT01099618)
Timeframe: 3 years

Interventiondays (Median)
Metformin472
Sitagliptin589
Placebo111

Reviews

8 reviews available for metformin and Acidosis, Diabetic

ArticleYear
COVID-19 in diabetic patients: Related risks and specifics of management.
    Annales d'endocrinologie, 2020, Volume: 81, Issue:2-3

    Topics: Acidosis, Lactic; Betacoronavirus; Comorbidity; Coronavirus Infections; COVID-19; Critical Illness;

2020
[Post-transplantation diabetes in kidney transplant: from the diabetologist point of view].
    Revue medicale suisse, 2020, Jun-10, Volume: 16, Issue:697

    Topics: Diabetes Mellitus; Diabetic Ketoacidosis; Dipeptidyl-Peptidase IV Inhibitors; Humans; Hypoglycemic A

2020
Dissecting the interaction between COVID-19 and diabetes mellitus.
    Journal of diabetes investigation, 2020, Volume: 11, Issue:5

    Topics: Antibodies, Monoclonal, Humanized; Antiviral Agents; Blood Glucose; Chloroquine; Comorbidity; COVID-

2020
THE PHYSIOLOGY BEHIND DIABETES MELLITUS IN PATIENTS WITH PHEOCHROMOCYTOMA: A REVIEW OF THE LITERATURE.
    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 2017, Volume: 23, Issue:8

    Topics: Adrenal Gland Neoplasms; Adult; Aged; Blood Glucose; Catecholamines; Diabetes Mellitus; Diabetes Mel

2017
SGLT2 inhibitors and metformin: Dual antihyperglycemic therapy and the risk of metabolic acidosis in type 2 diabetes.
    European journal of pharmacology, 2019, Mar-05, Volume: 846

    Topics: Acidosis, Lactic; Benzhydryl Compounds; Canagliflozin; Diabetes Mellitus, Type 2; Diabetic Ketoacido

2019
[Behavior of lactate and pyruvate in diabetics during ambulatory treatment with biguanides or with a combination of biguanides and sulfonylureas. II].
    La Clinica terapeutica, 1980, Jun-30, Volume: 93, Issue:6

    Topics: Aged; Ambulatory Care; Biguanides; Diabetes Mellitus; Diabetic Ketoacidosis; Drug Combinations; Fema

1980
Metformin and lactic acidosis in diabetic humans.
    Diabetes, obesity & metabolism, 2000, Volume: 2, Issue:3

    Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Diabetic Ketoacidosis; Humans; Hypoglycemic Agents; Met

2000
Advances in the treatment of diabetes mellitus.
    The Practitioner, 1971, Volume: 207, Issue:240

    Topics: Blood Glucose; Chlorpropamide; Clofibrate; Diabetes Mellitus; Diabetic Coma; Diabetic Ketoacidosis;

1971

Trials

1 trial available for metformin and Acidosis, Diabetic

ArticleYear
Randomized Controlled Study of Metformin and Sitagliptin on Long-term Normoglycemia Remission in African American Patients With Hyperglycemic Crises.
    Diabetes care, 2016, Volume: 39, Issue:11

    Topics: Adolescent; Adult; Black or African American; Body Mass Index; Diabetes Mellitus, Type 2; Diabetic K

2016

Other Studies

38 other studies available for metformin and Acidosis, Diabetic

ArticleYear
Possible association between diabetic ketoacidosis and use of sodium-glucose co-transporter 2 inhibitor in a 17-year-old youth with type 2 diabetes.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2021, 09-07, Volume: 193, Issue:35

    Topics: Adolescent; Canagliflozin; Diabetes Mellitus, Type 2; Diabetic Ketoacidosis; Humans; Hypoglycemic Ag

2021
Diabetic ketoacidosis as first presentation of latent autoimmune diabetes in adults in a patient with hashitoxicosis as first presentation of Hashimoto's thyroiditis: a case report.
    Journal of medical case reports, 2022, Aug-03, Volume: 16, Issue:1

    Topics: Adult; Autoantibodies; Diabetes Mellitus, Type 1; Diabetic Ketoacidosis; Hashimoto Disease; Humans;

2022
COVID-19 and diabetic ketoacidosis: A case series at an urban district hospital in South Africa.
    South African family practice : official journal of the South African Academy of Family Practice/Primary Care, 2022, 09-22, Volume: 64, Issue:1

    Topics: Adult; Biphasic Insulins; COVID-19; Diabetes Mellitus, Type 2; Diabetic Ketoacidosis; Female; Glycat

2022
Severe lactic acidosis with euglycemic diabetic ketoacidosis due to metformin overdose.
    CEN case reports, 2023, Volume: 12, Issue:4

    Topics: Acidosis; Acidosis, Lactic; Diabetes Mellitus, Type 2; Diabetic Ketoacidosis; Female; Humans; Ketone

2023
Diabetic ketoacidosis in patients with type 2 diabetes treated with sodium glucose co-transporter 2 inhibitors versus other antihyperglycemic agents: An observational study of four US administrative claims databases.
    Pharmacoepidemiology and drug safety, 2019, Volume: 28, Issue:12

    Topics: Administrative Claims, Healthcare; Aged; Blood Glucose; Databases, Factual; Diabetes Mellitus, Type

2019
Dapagliflozin-associated euglycemic diabetic ketoacidosis in a patient with type 2 diabetes mellitus: A case report.
    Medicine, 2020, May-22, Volume: 99, Issue:21

    Topics: Administration, Intravenous; Aged; Anti-Bacterial Agents; Benzhydryl Compounds; Blood Glucose; Diabe

2020
Sodium-Glucose Cotransporter 2 Inhibitors in the Era of COVID-19 Pandemic: Is the Benefit to Risk Ratio Still Favorable?
    Journal of diabetes science and technology, 2020, Volume: 14, Issue:4

    Topics: Betacoronavirus; Cardiovascular Diseases; Coronavirus Infections; COVID-19; Cytokines; Diabetes Mell

2020
Severe Complication of Diabetic Ketoacidosis and Metformin Intoxication: Bilateral Leg Amputation.
    Klinische Padiatrie, 2021, Volume: 233, Issue:5

    Topics: Amputation, Surgical; Diabetes Mellitus, Type 1; Diabetic Ketoacidosis; Humans; Leg; Metformin

2021
Rapid Onset of Diabetic Ketoacidosis After SGLT2 Inhibition in a Patient With Unrecognized Acromegaly.
    The Journal of clinical endocrinology and metabolism, 2017, 05-01, Volume: 102, Issue:5

    Topics: Adenoma; Benzhydryl Compounds; Diabetes Mellitus, Type 2; Diabetic Ketoacidosis; Drug Therapy, Combi

2017
Insulin-induced edema: an unusual complication in a patient with diabetic ketosis.
    La Tunisie medicale, 2017, Volume: 95, Issue:2

    Topics: Adult; Diabetes Mellitus, Type 2; Diabetic Ketoacidosis; Edema; Humans; Insulin; Male; Metformin

2017
Eruptive xanthomas in a patient with soft-drink diabetic ketosis and apolipoprotein E4/2.
    Endocrine journal, 2019, Jan-28, Volume: 66, Issue:1

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adolescent; Apolipoprotein E2; Apolipoprotein E4; Carbonated B

2019
Atypical presentation of Crimean-Congo haemorrhagic fever: Lessons learned.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 2019, Jan-31, Volume: 109, Issue:2

    Topics: Acidosis; Comorbidity; Diabetes Mellitus, Type 2; Diabetic Ketoacidosis; Diagnosis, Differential; Dr

2019
An enigmatic triad of acute pancreatitis, diabetic ketoacidosis and hypertriglyceridaemia: who is the culprit?
    BMJ case reports, 2019, Jul-10, Volume: 12, Issue:7

    Topics: Adult; Diabetes Mellitus, Type 2; Diabetic Ketoacidosis; Fluid Therapy; Humans; Hydroxymethylglutary

2019
Pituitary gigantism presenting with depressive mood disorder and diabetic ketoacidosis in an Asian adolescent.
    Journal of pediatric endocrinology & metabolism : JPEM, 2013, Volume: 26, Issue:9-10

    Topics: Adenoma; Adolescent; Adolescent Development; Antineoplastic Agents, Hormonal; Combined Modality Ther

2013
Euglycaemic diabetic ketoacidosis in a patient with type 2 diabetes started on empagliflozin.
    BMJ case reports, 2016, May-13, Volume: 2016

    Topics: Adult; Benzhydryl Compounds; Diabetes Mellitus, Type 2; Diabetic Ketoacidosis; Drug Therapy, Combina

2016
[Acidosis without marked hyperglycemia : Euglycemic diabetic ketoacidosis associated with SGLT2-Inhibitors].
    Medizinische Klinik, Intensivmedizin und Notfallmedizin, 2017, Volume: 112, Issue:2

    Topics: Benzhydryl Compounds; Blood Glucose; Combined Modality Therapy; Diabetes Mellitus, Type 2; Diabetic

2017
Euglycemic Diabetic Ketoacidosis with Elevated Acetone in a Patient Taking a Sodium-Glucose Cotransporter-2 (SGLT2) Inhibitor.
    The Journal of emergency medicine, 2017, Volume: 52, Issue:2

    Topics: Acetone; Antihypertensive Agents; Blood Glucose; Canagliflozin; Diabetes Complications; Diabetic Ket

2017
[Does a reduced kidney function (creatinine clearance 10-15 ml/min), without acidosis, increase the risk for the rise of lactic acidosis caused by metformin?].
    Nederlands tijdschrift voor geneeskunde, 2002, Nov-16, Volume: 146, Issue:46

    Topics: Acidosis, Lactic; Contraindications; Diabetes Mellitus, Type 2; Diabetic Ketoacidosis; Diabetic Neph

2002
Type 2 diabetes presenting as diabetic ketoacidosis in adolescence.
    Diabetic medicine : a journal of the British Diabetic Association, 2003, Volume: 20, Issue:5

    Topics: Acanthosis Nigricans; Adolescent; Blood Glucose; Body Weight; C-Peptide; Diabetes Mellitus, Type 2;

2003
Diabetic ketoacidosis in a patient with chronic calcific pancreatitis after minor papilla stent insertion.
    Gastrointestinal endoscopy, 2004, Volume: 59, Issue:3

    Topics: Alcoholism; Calcinosis; Cholangiopancreatography, Endoscopic Retrograde; Chronic Disease; Diabetic K

2004
[Reversible lactic acidosis in a diabetic on high dose metformin (author's transl)].
    Diabete & metabolisme, 1980, Volume: 6, Issue:3

    Topics: Adenoma; Diabetes Complications; Diabetes Mellitus; Diabetic Ketoacidosis; Humans; Lactates; Male; M

1980
Metformin and contrast media: genuine risk or witch hunt?
    Radiology, 1996, Volume: 201, Issue:3

    Topics: Contraindications; Contrast Media; Diabetes Mellitus; Diabetic Ketoacidosis; Diabetic Nephropathies;

1996
Lactic acidosis associated with Glucophage use in a man with normal renal and hepatic function.
    Diabetes care, 1997, Volume: 20, Issue:2

    Topics: Acidosis, Lactic; Diabetes Mellitus, Type 2; Diabetic Ketoacidosis; Drug Therapy, Combination; Human

1997
Contraindications to metformin therapy in patients with NIDDM.
    Diabetes care, 1997, Volume: 20, Issue:6

    Topics: Acidosis, Lactic; Alcoholism; Contraindications; Diabetes Mellitus, Type 2; Diabetic Ketoacidosis; D

1997
Clinical problem-solving. The importance of a name.
    The New England journal of medicine, 1999, May-06, Volume: 340, Issue:18

    Topics: Acanthosis Nigricans; Adolescent; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, T

1999
Biguanides and lacticacidosis.
    Lancet (London, England), 1977, Jan-22, Volume: 1, Issue:8004

    Topics: Diabetes Mellitus; Diabetic Ketoacidosis; Diet, Diabetic; Humans; Lactates; Metformin; Phenformin

1977
Metformin-induced lactic acidosis in the presence of acute renal failure.
    Diabetologia, 1977, Volume: 13, Issue:3

    Topics: Acute Kidney Injury; Adult; Aged; Alanine; Blood Glucose; Creatinine; Diabetic Ketoacidosis; Female;

1977
Treatment of normal-weight diabetics.
    British medical journal, 1978, Feb-25, Volume: 1, Issue:6111

    Topics: Body Weight; Diabetes Mellitus; Diabetic Ketoacidosis; Humans; Metformin

1978
[Letter: Lactic acidosis during renal insufficiency in two diabetic patients treated with metformin].
    La Nouvelle presse medicale, 1976, Apr-10, Volume: 5, Issue:15

    Topics: Aged; Diabetes Mellitus; Diabetic Ketoacidosis; Female; Humans; Kidney Failure, Chronic; Lactates; M

1976
Hemodialysis in the treatment of lactic acidosis in diabetics treated by metformin: a study of metformin elimination.
    International journal of clinical pharmacology, therapy, and toxicology, 1989, Volume: 27, Issue:6

    Topics: Acidosis, Lactic; Chromatography, Gas; Diabetic Ketoacidosis; Humans; Metformin; Renal Dialysis

1989
[Physiopathological approach to pathological hyperlactatemia in the diabetic patient. Value of blood metformin].
    Annales francaises d'anesthesie et de reanimation, 1987, Volume: 6, Issue:2

    Topics: Acidosis, Lactic; Adult; Aged; Diabetes Mellitus, Type 2; Diabetic Ketoacidosis; Female; Humans; Lac

1987
[Alteration of blood lactic acid levels in biguanide therapy in diabetics].
    Sichuan yi xue yuan xue bao = Acta Academiae Medicinae Sichuan, 1985, Volume: 16, Issue:2

    Topics: Biguanides; Blood Glucose; Diabetes Mellitus, Type 2; Diabetic Ketoacidosis; Humans; Lactates; Lacti

1985
Metformin and lactic acidosis.
    Lancet (London, England), 1972, Feb-05, Volume: 1, Issue:7745

    Topics: Acute Kidney Injury; Aged; Diabetes Mellitus; Diabetic Ketoacidosis; Female; Humans; Lactates; Metfo

1972
[Biguanides and lactic acid acidosis].
    Lakartidningen, 1973, Oct-03, Volume: 70, Issue:40

    Topics: Adult; Diabetic Ketoacidosis; Humans; Lactates; Metformin; Middle Aged; Phenformin; Sweden

1973
The treatment of lactic acidosis in the diabetic patient by peritoneal dialysis using sodium acetate. A report of two cases.
    Diabetologia, 1974, Volume: 10, Issue:5

    Topics: Acetates; Acute Kidney Injury; Aged; Bicarbonates; Blood Glucose; Carbon Dioxide; Chlorides; Diabeti

1974
[Reversible hyperlactatemia induced by phenformin with muscular asthenia and cardio-respiratory signs].
    La Presse medicale, 1970, Jan-03, Volume: 78, Issue:1

    Topics: Aged; Animals; Asthenia; Diabetes Complications; Diabetic Ketoacidosis; Dyspnea; Heart Diseases; Hep

1970
[Lactic acidosis and sugar diabetics].
    Helvetica medica acta, 1970, Volume: 35, Issue:5

    Topics: Alcoholism; Diabetic Ketoacidosis; Humans; Hypoxia; Lactates; Metformin; Phenformin; Starvation

1970
Lactic acidosis through medicaments.
    Helvetica medica acta, 1970, Volume: 35, Issue:5

    Topics: Acetates; Acidosis; Animals; Culture Techniques; Diabetes Mellitus; Diabetic Ketoacidosis; Female; G

1970