metformin has been researched along with Abortion, Habitual in 13 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Abortion, Habitual: Three or more consecutive spontaneous abortions.
| Excerpt | Relevance | Reference |
|---|---|---|
| " 'Cases' were women with PCOS who conceived while taking Metformin and it whom it was continued throughout pregnancy." | 9.14 | Continuation of metformin reduces early pregnancy loss in obese Pakistani women with polycystic ovarian syndrome. ( Nawaz, FH; Rizvi, J, 2010) |
| "To report the effect of metformin treatment on a patient with recurrent miscarriage (RM) and polycystic ovary syndrome (PCOS)." | 7.73 | Metformin hydrochloride and recurrent miscarriage in a woman with polycystic ovary syndrome. ( Falbo, A; Orio, F; Palomba, S; Russo, T; Tolino, A; Zullo, F, 2006) |
| " No adverse maternal-fetal side effects were reported on enoxaparin alone or enoxaparin-metformin." | 6.74 | Enoxaparin-metformin and enoxaparin alone may safely reduce pregnancy loss. ( Glueck, CJ; Goldenberg, N; Khan, N; Ramidi, G; Wang, P, 2009) |
| " 'Cases' were women with PCOS who conceived while taking Metformin and it whom it was continued throughout pregnancy." | 5.14 | Continuation of metformin reduces early pregnancy loss in obese Pakistani women with polycystic ovarian syndrome. ( Nawaz, FH; Rizvi, J, 2010) |
| "Continuation of pregnancy beyond the first trimester in all groups and presence or absence of teratogenicity in the delivered baby after metformin therapy." | 5.13 | Relationship between abnormal glucose tolerance test and history of previous recurrent miscarriages, and beneficial effect of metformin in these patients: a prospective clinical study. ( Kazerooni, T; Soveid, M; Taghieh, M; Tavana, Z; Zolghadri, J, 2008) |
| " Combined aspirin and heparin for antiphospholipid syndrome, and screening and treatment of bacterial vaginosis between ten and 22 weeks of pregnancy with clindamycin, are the only interventions proven to be useful in randomised controlled trials (RCTs)." | 4.84 | Non-surgical interventions for threatened and recurrent miscarriages. ( Tan, TY; Tien, JC, 2007) |
| "To report the effect of metformin treatment on a patient with recurrent miscarriage (RM) and polycystic ovary syndrome (PCOS)." | 3.73 | Metformin hydrochloride and recurrent miscarriage in a woman with polycystic ovary syndrome. ( Falbo, A; Orio, F; Palomba, S; Russo, T; Tolino, A; Zullo, F, 2006) |
| "Measures of thrombophilia, hypofibrinolysis, reproductive hormones, and androgenic steroids before and after metformin therapy." | 3.70 | Polycystic ovary syndrome, infertility, familial thrombophilia, familial hypofibrinolysis, recurrent loss of in vitro fertilized embryos, and miscarriage. ( Awadalla, SG; Cameron, D; Fontaine, RN; Glueck, CJ; Phillips, H; Wang, P, 2000) |
| " No adverse maternal-fetal side effects were reported on enoxaparin alone or enoxaparin-metformin." | 2.74 | Enoxaparin-metformin and enoxaparin alone may safely reduce pregnancy loss. ( Glueck, CJ; Goldenberg, N; Khan, N; Ramidi, G; Wang, P, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (61.54) | 29.6817 |
| 2010's | 4 (30.77) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Mahey, R | 1 |
| Gupta, M | 1 |
| Bansiwal, R | 1 |
| Sethi, A | 1 |
| Yan, Y | 1 |
| Bao, S | 1 |
| Sheng, S | 1 |
| Wang, L | 1 |
| Tu, W | 1 |
| Alecsandru, D | 1 |
| Barrio, A | 1 |
| Andia, V | 1 |
| Cruz, E | 1 |
| Aparicio, P | 1 |
| Serna, J | 1 |
| Cruz, M | 1 |
| Pellicer, A | 1 |
| Garcia-Velasco, JA | 1 |
| Ke, RW | 1 |
| Cocksedge, KA | 1 |
| Li, TC | 1 |
| Saravelos, SH | 1 |
| Metwally, M | 1 |
| Ramidi, G | 1 |
| Khan, N | 1 |
| Glueck, CJ | 3 |
| Wang, P | 3 |
| Goldenberg, N | 2 |
| Nawaz, FH | 1 |
| Rizvi, J | 1 |
| Sieve, L | 1 |
| Palomba, S | 1 |
| Falbo, A | 1 |
| Orio, F | 1 |
| Russo, T | 1 |
| Tolino, A | 1 |
| Zullo, F | 1 |
| Manno, M | 1 |
| Tomei, F | 1 |
| Marchesan, E | 1 |
| Zolghadri, J | 1 |
| Tavana, Z | 1 |
| Kazerooni, T | 1 |
| Soveid, M | 1 |
| Taghieh, M | 1 |
| Tien, JC | 1 |
| Tan, TY | 1 |
| Awadalla, SG | 1 |
| Phillips, H | 1 |
| Cameron, D | 1 |
| Fontaine, RN | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Metformin on Healthy Live Birth After In-vitro Fertilization in Women With Prediabetes Mellitus: a Multicenter Double-blind Placebo Controlled Randomized Trial[NCT06064669] | 988 participants (Anticipated) | Interventional | 2023-10-01 | Not yet recruiting | |||
| [NCT01784380] | 1,159 participants (Actual) | Observational | 2006-10-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for metformin and Abortion, Habitual
| Article | Year |
|---|---|
Endocrine basis for recurrent pregnancy loss.
Topics: Abortion, Habitual; Female; Humans; Hyperinsulinism; Hyperprolactinemia; Hypoglycemic Agents; Lutein | 2014 |
Non-surgical interventions for threatened and recurrent miscarriages.
Topics: Abortion, Habitual; Abortion, Threatened; Antiphospholipid Syndrome; Aspirin; Bed Rest; Chorionic Go | 2007 |
4 trials available for metformin and Abortion, Habitual
| Article | Year |
|---|---|
Enoxaparin-metformin and enoxaparin alone may safely reduce pregnancy loss.
Topics: Abortion, Habitual; Abortion, Spontaneous; Adult; Anticoagulants; Blood Coagulation Disorders; Dose- | 2009 |
Continuation of metformin reduces early pregnancy loss in obese Pakistani women with polycystic ovarian syndrome.
Topics: Abortion, Habitual; Adult; Body Mass Index; Case-Control Studies; Diabetes, Gestational; Female; Fet | 2010 |
Pregnancy loss, polycystic ovary syndrome, thrombophilia, hypofibrinolysis, enoxaparin, metformin.
Topics: Abortion, Habitual; Abortion, Spontaneous; Adult; Blood Coagulation Disorders; Case-Control Studies; | 2004 |
Relationship between abnormal glucose tolerance test and history of previous recurrent miscarriages, and beneficial effect of metformin in these patients: a prospective clinical study.
Topics: Abortion, Habitual; Adolescent; Adult; Comorbidity; Female; Glucose Tolerance Test; Humans; Hyperins | 2008 |
Relationship between abnormal glucose tolerance test and history of previous recurrent miscarriages, and beneficial effect of metformin in these patients: a prospective clinical study.
Topics: Abortion, Habitual; Adolescent; Adult; Comorbidity; Female; Glucose Tolerance Test; Humans; Hyperins | 2008 |
Relationship between abnormal glucose tolerance test and history of previous recurrent miscarriages, and beneficial effect of metformin in these patients: a prospective clinical study.
Topics: Abortion, Habitual; Adolescent; Adult; Comorbidity; Female; Glucose Tolerance Test; Humans; Hyperins | 2008 |
Relationship between abnormal glucose tolerance test and history of previous recurrent miscarriages, and beneficial effect of metformin in these patients: a prospective clinical study.
Topics: Abortion, Habitual; Adolescent; Adult; Comorbidity; Female; Glucose Tolerance Test; Humans; Hyperins | 2008 |
7 other studies available for metformin and Abortion, Habitual
| Article | Year |
|---|---|
Successful IVF outcome after repeat laparoscopic ovarian drilling in a case of resistant PCOS.
Topics: Abortion, Habitual; Adult; Female; Fertilization in Vitro; Glucose Metabolism Disorders; Humans; Hyp | 2020 |
Insulin resistance in patients with recurrent pregnancy loss is associated with lymphocyte population aberration.
Topics: Abortion, Habitual; Adult; Body Mass Index; CD3 Complex; CD4 Lymphocyte Count; CD56 Antigen; Fasting | 2017 |
Pancreatic autoimmunity: An unknown etiology on patients with assisted reproductive techniques (ART)-recurrent reproductive failure.
Topics: Abortion, Habitual; Adult; Autoimmunity; Birth Rate; Diabetes Mellitus; Female; Glucose Tolerance Te | 2018 |
A reappraisal of the role of polycystic ovary syndrome in recurrent miscarriage.
Topics: Abortion, Habitual; Androgens; Anovulation; Female; Gonadotropins; Humans; Infertility, Female; Insu | 2008 |
Metformin hydrochloride and recurrent miscarriage in a woman with polycystic ovary syndrome.
Topics: Abortion, Habitual; Adult; Diabetes, Gestational; Female; Humans; Hypoglycemic Agents; Metformin; Po | 2006 |
Polycystic ovary-related miscarriage: should metformin be proposed to such frustrated women?
Topics: Abortion, Habitual; Adult; Female; Humans; Metformin; Polycystic Ovary Syndrome; Pregnancy | 2007 |
Polycystic ovary syndrome, infertility, familial thrombophilia, familial hypofibrinolysis, recurrent loss of in vitro fertilized embryos, and miscarriage.
Topics: Abortion, Habitual; Adult; Amenorrhea; Androstenedione; Embryo Transfer; Female; Fertilization in Vi | 2000 |