metformin has been researched along with Abnormalities, Autosome in 6 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The chronic treatment of inbred 129/Sv mice with metformin (100 mg/kg in drinking water) slightly modified the food consumption but failed to influence the dynamics of body weight, decreased by 13." | 7.76 | Gender differences in metformin effect on aging, life span and spontaneous tumorigenesis in 129/Sv mice. ( Anisimov, VN; Berstein, LM; Egormin, PA; Kovalenko, IG; Piskunova, TS; Popovich, IG; Poroshina, TE; Rosenfeld, SV; Semenchenko, AV; Tyndyk, ML; Yurova, MV; Zabezhinski, MA, 2010) |
| " The chronic treatment of inbred 129/Sv mice with metformin (100 mg/kg in drinking water) slightly modified the food consumption but failed to influence the dynamics of body weight, decreased by 13." | 3.76 | Gender differences in metformin effect on aging, life span and spontaneous tumorigenesis in 129/Sv mice. ( Anisimov, VN; Berstein, LM; Egormin, PA; Kovalenko, IG; Piskunova, TS; Popovich, IG; Poroshina, TE; Rosenfeld, SV; Semenchenko, AV; Tyndyk, ML; Yurova, MV; Zabezhinski, MA, 2010) |
| "Metformin is a biguanide drug that is widely used in the treatment of diabetes." | 1.46 | Selective cytotoxicity of the anti-diabetic drug, metformin, in glucose-deprived chicken DT40 cells. ( Ide, H; Ishiai, M; Kadoda, K; Masunaga, SI; Moriwaki, T; Sasanuma, H; Takata, M; Takeda, S; Tano, K; Tsuda, M, 2017) |
| "Metformin is a widely prescribed drug used in the treatment of patients with type 2 diabetes." | 1.43 | The radioprotective effect of metformin against cytotoxicity and genotoxicity induced by ionizing radiation in cultured human blood lymphocytes. ( Bazzaz, JT; Cheki, M; Hosseinimehr, SJ; Mahmoudzadeh, A; Shirazi, A, 2016) |
| "Metformin is a hypoglycemiant drug prescribed for the treatment and control of the type 2 diabetes mellitus." | 1.39 | Metformin's performance in in vitro and in vivo genetic toxicology studies. ( Castro-Prado, MA; Della-Rosa, VA; Franco, CC; Mathias, PC; Prioli, AJ; Rosada, LJ; Sant'Anna, JR; Yajima, JP, 2013) |
| "Treatment with metformin ameliorated these biochemical markers." | 1.35 | Assessment of genomic instability in normal and diabetic rats treated with metformin. ( Alhaider, AA; Attia, SM; Helal, GK, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 5 (83.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kadoda, K | 1 |
| Moriwaki, T | 1 |
| Tsuda, M | 1 |
| Sasanuma, H | 1 |
| Ishiai, M | 1 |
| Takata, M | 1 |
| Ide, H | 1 |
| Masunaga, SI | 1 |
| Takeda, S | 1 |
| Tano, K | 1 |
| Sant'Anna, JR | 1 |
| Yajima, JP | 1 |
| Rosada, LJ | 1 |
| Franco, CC | 1 |
| Prioli, AJ | 1 |
| Della-Rosa, VA | 1 |
| Mathias, PC | 1 |
| Castro-Prado, MA | 1 |
| Cheki, M | 1 |
| Shirazi, A | 1 |
| Mahmoudzadeh, A | 1 |
| Bazzaz, JT | 1 |
| Hosseinimehr, SJ | 1 |
| Attia, SM | 1 |
| Helal, GK | 1 |
| Alhaider, AA | 1 |
| Harris, SE | 1 |
| Maruthini, D | 1 |
| Tang, T | 1 |
| Balen, AH | 1 |
| Picton, HM | 1 |
| Anisimov, VN | 1 |
| Piskunova, TS | 1 |
| Popovich, IG | 1 |
| Zabezhinski, MA | 1 |
| Tyndyk, ML | 1 |
| Egormin, PA | 1 |
| Yurova, MV | 1 |
| Rosenfeld, SV | 1 |
| Semenchenko, AV | 1 |
| Kovalenko, IG | 1 |
| Poroshina, TE | 1 |
| Berstein, LM | 1 |
6 other studies available for metformin and Abnormalities, Autosome
| Article | Year |
|---|---|
Selective cytotoxicity of the anti-diabetic drug, metformin, in glucose-deprived chicken DT40 cells.
Topics: Animals; Cell Line; Cell Survival; Chickens; Chromosome Aberrations; DNA Breaks, Double-Stranded; DN | 2017 |
Metformin's performance in in vitro and in vivo genetic toxicology studies.
Topics: Adult; Aspergillus nidulans; Chromatids; Chromosome Aberrations; Chromosome Segregation; Chromosomes | 2013 |
The radioprotective effect of metformin against cytotoxicity and genotoxicity induced by ionizing radiation in cultured human blood lymphocytes.
Topics: Adult; Apoptosis; Cells, Cultured; Chromosome Aberrations; Cytoprotection; DNA Damage; Dose-Response | 2016 |
Assessment of genomic instability in normal and diabetic rats treated with metformin.
Topics: Animals; Chromosome Aberrations; Diabetes Mellitus, Experimental; Drug Administration Schedule; Geno | 2009 |
Metabolism and karyotype analysis of oocytes from patients with polycystic ovary syndrome.
Topics: Adult; Carbohydrate Metabolism; Cell Differentiation; Cells, Cultured; Chromosome Aberrations; Chrom | 2010 |
Gender differences in metformin effect on aging, life span and spontaneous tumorigenesis in 129/Sv mice.
Topics: Age Factors; Aging; Animals; Blood Glucose; Body Temperature; Body Weight; Cholesterol; Chromosome A | 2010 |