metformin has been researched along with Aberrant Crypt Foci in 6 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Aberrant Crypt Foci: Clusters of colonic crypts that appear different from the surrounding mucosa when visualized after staining. They are of interest as putative precursors to colorectal adenomas and potential biomarkers for colorectal carcinoma.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This research was carried out to evaluate the chemopreventive effects of different doses of metformin treatment for 6 months on rectal aberrant crypt foci (ACF) in patients with impaired glucose tolerance (IGT)." | 9.20 | Effects of different doses of metformin treatment for 6 months on aberrant crypt foci in Chinese patients with impaired glucose tolerance. ( Chen, M; Chen, Y; Dai, Y; Li, Y; Wang, Y; Xie, H; Zhao, X, 2015) |
| "The incidence and mortality rates of colorectal cancer (CRC) continue to increase worldwide." | 6.94 | The efficacy of aspirin and metformin combination therapy in patients with rectal aberrant crypt foci: a double-blinded randomized controlled trial. ( Arimoto, J; Ashikari, K; Fuyuki, A; Higurashi, T; Matsuura, T; Misawa, N; Nakajima, A; Ohkubo, H; Takatsu, T; Yoshihara, T, 2020) |
| "This research was carried out to evaluate the chemopreventive effects of different doses of metformin treatment for 6 months on rectal aberrant crypt foci (ACF) in patients with impaired glucose tolerance (IGT)." | 5.20 | Effects of different doses of metformin treatment for 6 months on aberrant crypt foci in Chinese patients with impaired glucose tolerance. ( Chen, M; Chen, Y; Dai, Y; Li, Y; Wang, Y; Xie, H; Zhao, X, 2015) |
| "The incidence and mortality rates of colorectal cancer (CRC) continue to increase worldwide." | 2.94 | The efficacy of aspirin and metformin combination therapy in patients with rectal aberrant crypt foci: a double-blinded randomized controlled trial. ( Arimoto, J; Ashikari, K; Fuyuki, A; Higurashi, T; Matsuura, T; Misawa, N; Nakajima, A; Ohkubo, H; Takatsu, T; Yoshihara, T, 2020) |
| "Colorectal cancer is the third leading cause of cancer death in Japan and the United States and is strongly associated with obesity, especially visceral obesity." | 2.49 | Colon epithelial proliferation and carcinogenesis in diet-induced obesity. ( Endo, H; Hosono, K; Nakajima, A; Takahashi, H, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (83.33) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Higurashi, T | 1 |
| Arimoto, J | 1 |
| Ashikari, K | 1 |
| Takatsu, T | 1 |
| Misawa, N | 1 |
| Yoshihara, T | 1 |
| Matsuura, T | 1 |
| Fuyuki, A | 1 |
| Ohkubo, H | 1 |
| Nakajima, A | 3 |
| Takahashi, H | 2 |
| Hosono, K | 2 |
| Endo, H | 2 |
| Zhao, X | 1 |
| Li, Y | 1 |
| Chen, M | 1 |
| Chen, Y | 1 |
| Dai, Y | 1 |
| Wang, Y | 1 |
| Xie, H | 1 |
| Li, W | 1 |
| Wang, QL | 1 |
| Liu, X | 1 |
| Dong, SH | 1 |
| Li, HX | 1 |
| Li, CY | 1 |
| Guo, LS | 1 |
| Gao, JM | 1 |
| Berger, NA | 1 |
| Li, L | 1 |
| Ma, L | 1 |
| Wu, YJ | 1 |
| Bordini, HP | 1 |
| Kremer, JL | 1 |
| Fagundes, TR | 1 |
| Melo, GP | 1 |
| Conchon-Costa, I | 1 |
| da Silva, SS | 1 |
| Cecchini, AL | 1 |
| Panis, C | 1 |
| Luiz, RC | 1 |
| Sugiyama, M | 1 |
| Sakai, E | 1 |
| Uchiyama, T | 1 |
| Suzuki, K | 1 |
| Iida, H | 1 |
| Sakamoto, Y | 1 |
| Yoneda, K | 1 |
| Koide, T | 1 |
| Tokoro, C | 1 |
| Abe, Y | 1 |
| Inamori, M | 1 |
| Nakagama, H | 1 |
1 review available for metformin and Aberrant Crypt Foci
| Article | Year |
|---|---|
Colon epithelial proliferation and carcinogenesis in diet-induced obesity.
Topics: Aberrant Crypt Foci; Adiponectin; AMP-Activated Protein Kinases; Animals; Cell Proliferation; Cell T | 2013 |
3 trials available for metformin and Aberrant Crypt Foci
| Article | Year |
|---|---|
The efficacy of aspirin and metformin combination therapy in patients with rectal aberrant crypt foci: a double-blinded randomized controlled trial.
Topics: Aberrant Crypt Foci; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colorectal Neoplasms; Double- | 2020 |
Effects of different doses of metformin treatment for 6 months on aberrant crypt foci in Chinese patients with impaired glucose tolerance.
Topics: Aberrant Crypt Foci; Adult; Asian People; Blood Glucose; Diabetes Mellitus, Type 2; Female; Humans; | 2015 |
Metformin suppresses colorectal aberrant crypt foci in a short-term clinical trial.
Topics: Aberrant Crypt Foci; Adenoma; Aged; Antineoplastic Agents; Cell Proliferation; Clinical Trials as To | 2010 |
2 other studies available for metformin and Aberrant Crypt Foci
| Article | Year |
|---|---|
Combined use of vitamin D3 and metformin exhibits synergistic chemopreventive effects on colorectal neoplasia in rats and mice.
Topics: Aberrant Crypt Foci; Animals; Anticarcinogenic Agents; Blotting, Western; Cholecalciferol; Colorecta | 2015 |
Protective effect of metformin in an aberrant crypt foci model induced by 1,2-dimethylhydrazine: Modulation of oxidative stress and inflammatory process.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; AMP-Activated Protein Kinases; Animals; Cell Proliferati | 2017 |