Page last updated: 2024-11-07

metaraminol and Hypertension

metaraminol has been researched along with Hypertension in 55 studies

Metaraminol: A sympathomimetic agent that acts predominantly at alpha-1 adrenergic receptors. It has been used primarily as a vasoconstrictor in the treatment of HYPOTENSION.
metaraminol : A member of the class of phenylethanolamines that is 2-amino-1-phenylethanol substituted by a methyl group at position 2 and a phenolic hydroxy group at position 1. A sympathomimetic agent , it is used in the treatment of hypotension.

Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.

Research Excerpts

ExcerptRelevanceReference
" In 25 patients with either hypertension (8 cases) or ventricular ectopic rhythms (10 cases) or both (7 cases) the blood pressure was reduced by sodium nitroprusside (24 cases) and/or elevated with metaraminol (10 cases) and the signal averaging electrocardiogram was recorded under 2 or 3 pressure values on each patient."3.68Effect of acute blood pressure changes on signal averaged electrocardiogram. ( Kanakakis, J; Luani, K; Moulopoulos, SD; Papamichael, CM; Sideris, DA; Stringli, T; Toumanidis, ST, 1993)
"Mild acute hypertension was induced in rats pharmacologically and non-pharmacologically with metaraminol, angiotensin II or bilateral vagotomy."3.67Hypertension induced changes in cerebral capillary permeability to water are mediated by afferent neuronal connections from the carotid sinus to the brain. ( Clark, HB; Hartman, BK; Ling, RT, 1984)
"Interrelationship between the breakdown of the blood-brain barrier (BBB) to Evans blue and elevations in the regional cerebral blood flow (rCBF) was studied in rabbits subjected to adrenaline- or metaraminol-induced systemic hypertension and also in bicuculline-induced seizures."3.67Regional changes in cerebral blood flow and blood-brain barrier permeability during epileptiform seizures and in acute hypertension in rabbits. ( Fujiwara, K; Klatzo, I; Nitsch, C; Suzuki, R, 1984)
"We assessed the permeability surface area products at the blood-retinal barrier and blood-brain barrier to sucrose (molecular weight, 340) and microperoxidase (molecular weight, 2000) following acute hypertension induced by metaraminol in Wistar-Kyoto rats (controls) and during chronic hypertension in spontaneously hypertensive rats."3.67Assessment of the permeability of the blood-retinal barrier in hypertensive rats. ( Latker, C; Lightman, S; Palestine, A; Rapoport, S; Rechthand, E, 1987)
"Acute hypertension, induced either by intravenous injection of metaraminol bitartrate (Aramine), infusion of isotonic saline into the common carotid artery, or a combination of both procedures did not in the rhesus monkey lead to breakdown of the blood-retinal barrier."3.66Hypertensive breakdown of cerebral but not of retinal blood vessels in rhesus monkey. ( Laties, AM; McGlinn, A; Rapoport, SI, 1979)
"Acute hypertension in rats was produced by intravenous infusion of metaraminol bitartrate (Aramine)."3.65Increased vesicular transfer of horseradish peroxidase across cerebral endothelium, evoked by acute hypertension. ( Brondsted, HE; van Deurs, B; Westergaard, E, 1977)
"Acute hypertension was induced by metaraminol at different time intervals following irradiation in rabbits exposed to unilateral X-ray irradiation against the brain (3000 R) and in control animals."3.65Blood-brain barrier lesions in acute hypertension in rabbits after unilateral X-ray exposure of brain. ( Blomstrand, C; Johansson, B; Rosengren, B, 1975)
"Acute hypertension, experimentally induced by intravenous injection of metaraminol in adult rabbits, rapidly induced a damage of the blood-brain barrier in the cerebral cortex, as visualized by Evans-blue-conjugated albumin and horseradish peroxidase."3.65Ultrastructural studies on cerebrovascular permeability in acute hypertension. ( Blomstrand, C; Hansson, HA; Johansson, B, 1975)
"In 34 comatose patients in the acute phase, the mean hemispheric CBF is lowered as well as the CMRO2, with a quite good relation between these values and the coma level and prognostic so."1.26[Value of brain metabolic studies in post-traumatic coma]. ( Baldy-Moulinier, M; Escuret, E; Frerebeau, P; Roquefeuil, B; Viguie, E, 1977)

Research

Studies (55)

TimeframeStudies, this research(%)All Research%
pre-199052 (94.55)18.7374
1990's1 (1.82)18.2507
2000's2 (3.64)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
KELLER, ML1
CHAMBERLIN, RT1
PUTNAM, WS1
FREMONT, RE1
JAGENDORF, B1
SAMMARTINO, WF1
TOOLE, JF1
NYE, ER1
VAAMONDE, CA1
SPORN, IN1
LANCESTREMERE, RG1
BELSKY, JL1
PAPPER, S1
LEHNER, T1
COHEN, MH1
HORLER, AR1
WYNNE, NA1
MASSON, GM1
KAWAKITA, S1
Savage, R1
Beattie, C1
Sicuteri, F4
Del Bene, E4
Anselmi, B1
Del Bianco, PL3
Ling, RT1
Hartman, BK1
Clark, HB1
Brubakk, AM1
Bratlid, D1
Oh, W1
Yao, AC1
Stonestreet, BS1
Suzuki, R1
Nitsch, C1
Fujiwara, K1
Klatzo, I2
Ziylan, YZ1
Tulleken, CA1
van Dieren, A1
ten Veen, J1
Lopes da Silva, FH1
Rapoport, SI4
Fredericks, WR1
Laties, AM2
Sideris, DA3
Toumanidis, ST2
Papamichael, CM1
Stringli, T1
Kanakakis, J1
Luani, K1
Moulopoulos, SD3
Pissarek, M1
Ermert, J1
Oesterreich, G1
Bier, D1
Coenen, HH1
Roquefeuil, B1
Baldy-Moulinier, M1
Frerebeau, P1
Viguie, E1
Escuret, E1
McGlinn, A1
Slotkin, TA1
Green, HO1
Hope, DT1
Branston, NM1
Symon, L1
Brøndsted, HE1
Westergaard, E2
Johansson, B8
van Deurs, B1
Brondsted, HE1
Blomstrand, C2
Rosengren, B1
Hansson, HA1
Bill, A1
Linder, J1
Kontoyannis, DA1
Diakos, A1
Kontoyannis, SA1
Vailly, B1
Rougeron, G1
Weill, A1
Bollack, C1
Harnish, PP1
Hagberg, DJ1
Vardas, PE1
Chrysos, DN1
Michalis, L1
Lightman, S1
Rechthand, E1
Latker, C1
Palestine, A1
Rapoport, S1
Li, CL1
Olsson, Y1
Linder, LE1
Smookler, HH1
Severs, WB1
Kinnard, WJ1
Buckley, JP1
Berkmen, R2
Roguska, J1
Simon, NM1
del Greco, F1
Schmitt, H2
Baïsset, A1
Cotonat, J1
Montastruc, P1
Horwitz, D1
Alexander, RW1
Lovenberg, W1
Keiser, HR1
Hassler, O1
Buffoni, F1
Michelacci, S1
Sherwood, T1
Häggendal, E1
Eisinger, RP1

Reviews

3 reviews available for metaraminol and Hypertension

ArticleYear
Brain barrier pathology in acute arterial hypertension.
    Advances in experimental medicine and biology, 1976, Volume: 69

    Topics: Animals; Aorta, Thoracic; Blood Proteins; Blood-Brain Barrier; Brain; Capillary Permeability; Cats;

1976
[Adrenergic amines and monoaminoxidases in essential arterial hypertension].
    Acta vitaminologica et enzymologica, 1969, Volume: 23, Issue:1

    Topics: Blood Pressure; Brain Chemistry; Catecholamines; Hypertension; Liver; Metaraminol; Models, Biologica

1969
The physiology of intravenous urography.
    The Scientific basis of medicine annual reviews, 1971

    Topics: Angiography; Biological Transport, Active; Contrast Media; Dehydration; Diuresis; Furosemide; Glomer

1971

Other Studies

52 other studies available for metaraminol and Hypertension

ArticleYear
Vasopressor drugs in the treatment of cardiogenic shock.
    Maryland state medical journal, 1963, Volume: 12

    Topics: Humans; Hypertension; Mephentermine; Metaraminol; Methamphetamine; Myocardial Infarction; Norepineph

1963
PROLONGED CARDIOGENIC SHOCK. REPORT OF A CASE IN WHICH PREVIOUS PROLONGED THERAPY WITH A RESERPINE-LIKE DRUG MAY HAVE PLAYED A ROLE.
    The American journal of medicine, 1963, Volume: 35

    Topics: Humans; Hypertension; Metaraminol; Myocardial Infarction; Norepinephrine; Rauwolfia; Reserpine; Shoc

1963
CLINICAL OBSERVATIONS ON THE EFFICACY OF METARAMINOL IN THE TREATMENT OF SHOCK.
    Current therapeutic research, clinical and experimental, 1964, Volume: 6

    Topics: Cerebrovascular Disorders; Gastrointestinal Hemorrhage; Hemorrhage; Humans; Hypertension; Hypertensi

1964
REVERSED VERTEBRAL ARTERY FLOW. THE EFFECT OF LIMB EXERCISE AND HYPERTENSIVE AGENTS.
    Archives of neurology, 1964, Volume: 10

    Topics: Animals; Blood Circulation; Blood Pressure; Brachiocephalic Trunk; Carotid Arteries; Cerebral Infarc

1964
THE EFFECT OF BLOOD PRESSURE ALTERATION ON THE PULSE WAVE VELOCITY.
    British heart journal, 1964, Volume: 26

    Topics: Aorta; Blood Pressure; Bromides; Cerebrovascular Disorders; Electrocardiography; Femoral Artery; Hea

1964
AUGMENTED NATRIURETIC RESPONSE TO ACUTE SODIUM INFUSION AFTER BLOOD PRESSURE ELEVATION WITH METARAMINOL IN NORMOTENSIVE SUBJECTS.
    The Journal of clinical investigation, 1964, Volume: 43

    Topics: Blood Pressure; Humans; Hypertension; Metaraminol; Natriuresis; Pharmacology; Sodium; Sodium, Dietar

1964
SYSTEMIC CANDIDIASIS AND RENAL INVOLVEMENT.
    Lancet (London, England), 1964, Jun-27, Volume: 2, Issue:7348

    Topics: Anti-Bacterial Agents; Candidiasis; Chemical and Drug Induced Liver Injury; Chloramphenicol; Diagnos

1964
PROLONGED CARDIOGENIC SHOCK WITH RECOVERY.
    The Journal of the American Osteopathic Association, 1964, Volume: 63

    Topics: Angina Pectoris; Coronary Disease; Digoxin; Electrocardiography; Hydrochlorothiazide; Hypercholester

1964
HYPERTENSIVE CRISIS DUE TO PARGYLINE AND METARAMINOL.
    British medical journal, 1965, Aug-21, Volume: 2, Issue:5459

    Topics: Autonomic Nervous System Diseases; Drug Synergism; Drug Therapy; Headache; Hypertension; Metaraminol

1965
Experimental production of renal and vascular lesions with metaraminol.
    Cleveland Clinic quarterly, 1962, Volume: 29

    Topics: Humans; Hypertension; Hypertension, Renal; Kidney; Metaraminol; Sympathomimetics

1962
Inadvertent epidural administration of metaraminol.
    Anaesthesia, 2004, Volume: 59, Issue:6

    Topics: Aged; Humans; Hypertension; Injections, Epidural; Intraoperative Period; Male; Medication Errors; Me

2004
[Monoamine oxidase and essential arterial hypertension].
    Bollettino della Societa italiana di biologia sperimentale, 1967, Sep-15, Volume: 43, Issue:17

    Topics: Catecholamines; Cheese; Humans; Hypertension; Metaraminol; Monoamine Oxidase; Monoamine Oxidase Inhi

1967
Hypertension induced changes in cerebral capillary permeability to water are mediated by afferent neuronal connections from the carotid sinus to the brain.
    Brain research, 1984, Aug-13, Volume: 308, Issue:2

    Topics: Afferent Pathways; Angiotensin II; Animals; Body Water; Brain; Capillary Permeability; Carotid Sinus

1984
Atropine prevents increases in brain blood flow during hypertension in newborn piglets.
    Pediatric research, 1984, Volume: 18, Issue:11

    Topics: Animals; Animals, Newborn; Atropine; Blood Pressure; Cerebrovascular Circulation; Heart Rate; Hypert

1984
Regional changes in cerebral blood flow and blood-brain barrier permeability during epileptiform seizures and in acute hypertension in rabbits.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1984, Volume: 4, Issue:1

    Topics: Acute Disease; Animals; Bicuculline; Blood Pressure; Blood-Brain Barrier; Cerebrovascular Circulatio

1984
Pathophysiology of the opening of the blood-brain and blood-cerebrospinal fluid barriers in acute hypertension.
    Experimental neurology, 1984, Volume: 84, Issue:1

    Topics: Acute Disease; Animals; Blood Physiological Phenomena; Blood-Brain Barrier; Brain; Cerebrospinal Flu

1984
Changes in local cerebral blood flow, local EEG, and flow in the distal stump of the middle cerebral artery in cats with occlusion of the middle cerebral artery.
    Acta neurochirurgica, 1982, Volume: 61, Issue:1-3

    Topics: Animals; Arterial Occlusive Diseases; Cats; Cerebral Arteries; Cerebrovascular Circulation; Electrod

1982
Reversible opening of the retinal pigment epithelium by hypercapnia.
    Experimental eye research, 1980, Volume: 30, Issue:2

    Topics: Animals; Blood Pressure; Fluoresceins; Hypercapnia; Hypertension; Male; Metaraminol; Pigment Epithel

1980
Effect of acute blood pressure changes on signal averaged electrocardiogram.
    Acta cardiologica, 1993, Volume: 48, Issue:2

    Topics: Adult; Aged; Arrhythmias, Cardiac; Blood Pressure; Electrocardiography; Female; Humans; Hypertension

1993
Relative uptake, metabolism, and beta-receptor binding of (1R,2S)-4-(18)F-fluorometaraminol and (123)I-MIBG in normotensive and spontaneously hypertensive rats.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2002, Volume: 43, Issue:3

    Topics: 3-Iodobenzylguanidine; Adrenergic beta-Antagonists; Animals; Autoradiography; Cardiomyopathies; Hear

2002
[Value of brain metabolic studies in post-traumatic coma].
    Neuro-Chirurgie, 1977, Volume: 23, Issue:5

    Topics: Brain; Brain Diseases; Brain Injuries; Carbon Dioxide; Cerebrovascular Circulation; Coma; Female; Ho

1977
Blood-brain barrier opening by isotonic saline infusion in normotensive and hypertensive animals.
    Acta radiologica: diagnosis, 1978, Volume: 19, Issue:6

    Topics: Animals; Blood-Brain Barrier; Body Water; Brain Chemistry; Brain Edema; Carotid Artery, Internal; Co

1978
Hypertensive breakdown of cerebral but not of retinal blood vessels in rhesus monkey.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1979, Volume: 97, Issue:8

    Topics: Animals; Blood-Brain Barrier; Brain; Cerebral Arteries; Disease Models, Animal; Haplorhini; Hyperten

1979
Adrenal medullary storage vesicles of the spontaneously hypertensive rat.
    Biochemical pharmacology, 1975, Jan-15, Volume: 24, Issue:2

    Topics: Adenosine Triphosphate; Adrenal Glands; Adrenal Medulla; Animals; Carbon Radioisotopes; Catecholamin

1975
Restoration of neurological function with induced hypertension in acute experimental cerebral ischaemia.
    Acta neurologica Scandinavica. Supplementum, 1977, Volume: 64

    Topics: Animals; Brain; Cerebral Arteries; Cerebrovascular Circulation; Evoked Potentials; Haplorhini; Hyper

1977
Increased vesicular transport of horseradish peroxidase across the blood-brain barrier after chemical induction of hypertension.
    Advances in neurology, 1978, Volume: 20

    Topics: Animals; Blood-Brain Barrier; Capillary Permeability; Endothelium; Horseradish Peroxidase; Hypertens

1978
Increased vesicular transfer of horseradish peroxidase across cerebral endothelium, evoked by acute hypertension.
    Acta neuropathologica, 1977, Feb-28, Volume: 37, Issue:2

    Topics: Blood Vessels; Blood-Brain Barrier; Brain; Endothelium; Horseradish Peroxidase; Hypertension; Metara

1977
Opening of the blood-brain barrier by acute hypertension.
    Experimental neurology, 1976, Volume: 52, Issue:3

    Topics: Acute Disease; Animals; Blood Pressure; Blood-Brain Barrier; Hypertension; Metaraminol; Papaverine;

1976
Blood-brain barrier lesions in acute hypertension in rabbits after unilateral X-ray exposure of brain.
    Acta neuropathologica, 1975, Volume: 31, Issue:2

    Topics: Acute Disease; Animals; Blood-Brain Barrier; Brain; Capillary Permeability; Cerebral Hemorrhage; Cer

1975
Ultrastructural studies on cerebrovascular permeability in acute hypertension.
    Acta neuropathologica, 1975, Aug-27, Volume: 32, Issue:3

    Topics: Animals; Basement Membrane; Blood-Brain Barrier; Capillaries; Capillary Permeability; Cerebral Corte

1975
Sympathetic control of cerebral blood flow in acute arterial hypertension.
    Acta physiologica Scandinavica, 1976, Volume: 96, Issue:1

    Topics: Acute Disease; Angiotensin II; Animals; Aorta; Aorta, Thoracic; Blood Flow Velocity; Blood Pressure;

1976
Antihypertensive treatment for the management of premature ventricular complexes. Pilot study.
    Acta cardiologica, 1988, Volume: 43, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Amiloride; Antihypertensive Agents; Blood Pressure; Cardiac Complexe

1988
[Epilepsy and hypertensive crisis after intracavernous injection of metaraminol in the treatment of priapism secondary to a papaverine test].
    Presse medicale (Paris, France : 1983), 1989, May-20, Volume: 18, Issue:20

    Topics: Epilepsy; Humans; Hypertension; Male; Metaraminol; Middle Aged; Papaverine; Priapism

1989
Contrast media-induced blood-brain barrier damage. Potentiation by hypertension.
    Investigative radiology, 1988, Volume: 23, Issue:6

    Topics: Animals; Blood-Brain Barrier; Diatrizoate Meglumine; Hypertension; Male; Metaraminol; Rats; Rats, In

1988
An extravascular hydraulic system to control blood pressure by a feedback regulation of the venous return.
    Cardiovascular research, 1987, Volume: 21, Issue:5

    Topics: Animals; Blood Pressure Determination; Dogs; Feedback; Hypertension; Metaraminol; Prostheses and Imp

1987
Assessment of the permeability of the blood-retinal barrier in hypertensive rats.
    Hypertension (Dallas, Tex. : 1979), 1987, Volume: 10, Issue:4

    Topics: Acute Disease; Animals; Blood-Brain Barrier; Blood-Retinal Barrier; Chronic Disease; Hypertension; M

1987
The effect of acute arterial hypertension on the blood-brain barrier to protein tracers.
    Acta neuropathologica, 1970, Volume: 16, Issue:2

    Topics: Animals; Arteries; Blood-Brain Barrier; Brain; Cats; Cerebral Cortex; Electroencephalography; Histoc

1970
Blood-brain barrier dysfunction in acute arterial hypertension induced by clamping of the thoracic aorta.
    Acta neurologica Scandinavica, 1974, Volume: 50, Issue:3

    Topics: Acute Disease; Animals; Aorta, Thoracic; Azo Compounds; Blood-Brain Barrier; Cerebral Cortex; Cerebr

1974
Regional cerebral blood flow in acute experimental hypertension.
    Acta neurologica Scandinavica, 1974, Volume: 50, Issue:3

    Topics: Acute Disease; Animals; Azo Compounds; Blood-Brain Barrier; Cerebrovascular Circulation; Hypertensio

1974
Centrally mediated cardiovascular effects of angiotensin II.
    The Journal of pharmacology and experimental therapeutics, 1966, Volume: 153, Issue:3

    Topics: Angiotensin II; Animals; Blood Pressure; Brain; Cardiovascular System; Cats; Cerebral Ventricles; Hy

1966
[The value of the angiotensin infusion test in differential diagnosis].
    Turk Tip Cemiyeti mecmuasi, 1967, Volume: 33, Issue:4

    Topics: Angiotensin II; Glomerulonephritis; Heart Failure; Humans; Hypertension; Liver Cirrhosis; Metaramino

1967
Pressor response to angiotensin II in hypertension. Correlation with plasma renin activity and response to norepinephrine and metaraminol.
    The American journal of cardiology, 1968, Volume: 21, Issue:5

    Topics: Adolescent; Adult; Aged; Angiotensin II; Blood Pressure; Humans; Hypertension; Hypertension, Renal;

1968
[Changes in the hypertensive effects of angiotensin by adrenergic and anti-adrenergic agents].
    Archives internationales de pharmacodynamie et de therapie, 1968, Volume: 171, Issue:1

    Topics: Amphetamine; Angiotensin II; Animals; Blood Pressure; Bretylium Compounds; Cocaine; Desipramine; Dib

1968
[Diagnostic significance of the angiotensin infusion test].
    Revista medica de Chile, 1968, Volume: 96, Issue:10

    Topics: Adolescent; Adult; Aged; Angiotensin II; Child; Diabetic Nephropathies; Female; Glomerulonephritis;

1968
[Influence of hypocapnic gaseous alkalosis on beta effects of sympathomimetics].
    Pathologie-biologie, 1969, Volume: 17, Issue:1

    Topics: Acid-Base Equilibrium; Alkalosis; Anesthesia; Animals; Blood Pressure; Carbon Dioxide; Dogs; Ephedri

1969
Blood-brain barrier dysfunction in acute arterial hypertension after papaverine-induced vasodilatation.
    Acta neurologica Scandinavica, 1974, Volume: 50, Issue:5

    Topics: Albumins; Animals; Antipyrine; Azo Compounds; Blood-Brain Barrier; Brain; Capillary Permeability; Ca

1974
Human serum dopamine- -hydroxylase. Relationship to hypertension and sympathetic activity.
    Circulation research, 1973, Volume: 32, Issue:5

    Topics: Adrenal Gland Neoplasms; Adult; Amphetamine; Blood Flow Velocity; Blood Pressure; Dopamine beta-Hydr

1973
Arterial cell kinetics in experimental hypertension.
    Virchows Archiv. A, Pathological anatomy and histology, 1974, Volume: 362, Issue:4

    Topics: Animals; Aorta; Arteries; Autoradiography; Cell Movement; Female; Hypertension; Hypertension, Renal;

1974
On the pathophysiology of the increased cerebrovascular permeability in acute arterial hypertension in cats.
    Acta neurologica Scandinavica, 1972, Volume: 48, Issue:3

    Topics: Animals; Capillary Permeability; Cats; Cerebral Arteries; Coloring Agents; Hypertension; Metaraminol

1972
Migraine-headache and essential arterial hypertension. A clinical pharmacological approach with the false transmitter metaraminol.
    Research and clinical studies in headache, 1970, Volume: 3

    Topics: Blood Pressure; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Headache;

1970
Augmented natriuretic response to infusion of saline in dogs rendered acutely hypertensive with metaraminol.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1966, Volume: 122, Issue:3

    Topics: Adrenal Cortex Hormones; Aminohippuric Acids; Animals; Desoxycorticosterone; Dogs; Glomerular Filtra

1966
[Monoamine oxidase inhibition and hypertensive paroxysms: importance of the method of administration].
    Bollettino della Societa italiana di biologia sperimentale, 1966, Sep-15, Volume: 42, Issue:17

    Topics: Blood Pressure; Cheese; Humans; Hypertension; Injections, Intramuscular; Injections, Intravenous; Me

1966