metallothionein and Osteoarthritis--Knee

metallothionein has been researched along with Osteoarthritis--Knee* in 1 studies

Other Studies

1 other study(ies) available for metallothionein and Osteoarthritis--Knee

Article	Year
Distinct expression pattern of early- and late-response genes in normal and osteoarthritic human synovial membranes. Osteoarthritis and cartilage, 1993, Volume: 1, Issue:3 The significance of activating proteins (AP-1), c-fos, c-jun and jun B relative to the AP-1 responsive metallothionein, collagenase and stromelysin gene expression in the pathophysiology of osteoarthritis (OA) was investigated. The 'early' c-fos, c-jun and jun-B mRNAs were ubiquitously expressed in normal and OA human knee synovial membranes. There was no strict correlation between expression of these and the AP-1 responsive, collagenase and stromelysin gene expression. Interestingly, the total metallothionein (MT) and the AP-1 responsive, MT-IIA gene-specific mRNAs were greatly diminished in OA compared with normal synovial membranes. The possible role of reduced expression of MT and trace metals in OA pathophysiology is discussed. Collectively, these data demonstrate a discoordinate expression of AP-1 encoding and their target genes in synovium. Topics: Aged; Aged, 80 and over; Collagenases; Female; Gene Expression; Genes, fos; Genes, jun; Humans; Male; Matrix Metalloproteinase 3; Metallothionein; Middle Aged; Osteoarthritis, Knee; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; RNA, Messenger; Synovial Membrane	1993

Article

Year

Distinct expression pattern of early- and late-response genes in normal and osteoarthritic human synovial membranes.

Osteoarthritis and cartilage, 1993, Volume: 1, Issue:3

The significance of activating proteins (AP-1), c-fos, c-jun and jun B relative to the AP-1 responsive metallothionein, collagenase and stromelysin gene expression in the pathophysiology of osteoarthritis (OA) was investigated. The 'early' c-fos, c-jun and jun-B mRNAs were ubiquitously expressed in normal and OA human knee synovial membranes. There was no strict correlation between expression of these and the AP-1 responsive, collagenase and stromelysin gene expression. Interestingly, the total metallothionein (MT) and the AP-1 responsive, MT-IIA gene-specific mRNAs were greatly diminished in OA compared with normal synovial membranes. The possible role of reduced expression of MT and trace metals in OA pathophysiology is discussed. Collectively, these data demonstrate a discoordinate expression of AP-1 encoding and their target genes in synovium.

Topics: Aged; Aged, 80 and over; Collagenases; Female; Gene Expression; Genes, fos; Genes, jun; Humans; Male; Matrix Metalloproteinase 3; Metallothionein; Middle Aged; Osteoarthritis, Knee; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; RNA, Messenger; Synovial Membrane

1993