metallothionein and Lichen-Planus--Oral

metallothionein has been researched along with Lichen-Planus--Oral* in 2 studies

Other Studies

2 other study(ies) available for metallothionein and Lichen-Planus--Oral

Article	Year
Differential metallothionein expression in oral lichen planus and amalgam-associated oral lichenoid lesions. Medicina oral, patologia oral y cirugia bucal, 2018, May-01, Volume: 23, Issue:3 Oral lichen planus (OLP) is a chronic inflammatory disease mediated by T cells, which manifests as reticular (white) or erosive (red) lesions, that are eventually painful. Oral lichenoid lesion (OLL) are distinguished from OLP by the presence of precipitating factors. The aim of this study was to evaluate whether the presence of metallothionein, which is involved in anti-apoptotic pathways and the anti-oxidative response, could serve as a differential diagnostic for OLP and OLL.. We evaluated the expression of metallothionein in 40 cases of OLP and 20 cases of OLL using immunohistochemistry.. White OLP has higher concentrations of metallothionein than red OLP in basal and parabasal layers. Moreover, metallothionein was more frequently observed in the cytoplasm and nuclei of basal cells in OLP patients compared to the same regions of OLL cases. Metallothionein levels are related to OLP severity and may contribute to a differential diagnosis between OLP and OLL. Topics: Adult; Dental Amalgam; Diagnosis, Differential; Female; Humans; Lichen Planus, Oral; Male; Metallothionein; Middle Aged; Mouth Diseases	2018
Metallothionein, a marker of antiapoptosis, is associated with clinical forms of oral lichen planus. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2014, Volume: 43, Issue:10 To investigate the expression of anti- and proapoptosis markers, metallothionein (MT), and caspase-2, in the epithelial and inflammatory cells of oral lichen planus (OLP) patients, and to investigate the association with clinical parameters.. Included were biopsies of 70 OLP patients. The clinical data were collected from patients' charts. The expression of MT and caspase-2 was immunomorphometrically analyzed in the epithelial and inflammatory cells, and the results were correlated with the clinical presentation.. The epithelial and inflammatory cells expressed MT (10.2 ± 5.75 and 0.68 ± 0.86) and caspase-2 (1.54 ± 2.6 and 0.98 ± 1.15) which show a trend toward an inverse expression. The expression of MT in the epithelium was significantly higher in patients presenting with keratotic lichen planus than in patients with the atrophic and erosive forms (P = 0.0008). In the inflammatory cells, the expression of MT was inversely correlated with increasing age (R = 0.34, P = 0.0069).. The pattern of expression of MT and caspase-2 in OLP suggests an extensive antiapoptotic response in the keratotic form of the disease. Symptomatic patients may benefit from therapy targeted to apoptosis in the future. Topics: Adult; Age Factors; Aged; Aged, 80 and over; Apoptosis; Apoptosis Regulatory Proteins; Biopsy; Caspase 2; Cohort Studies; Cysteine Endopeptidases; Double-Blind Method; Epithelial Cells; Female; Follow-Up Studies; Humans; Inflammation; Lichen Planus, Oral; Male; Metallothionein; Middle Aged; Mouth Mucosa; Retrospective Studies	2014

Article

Year

Differential metallothionein expression in oral lichen planus and amalgam-associated oral lichenoid lesions.

Medicina oral, patologia oral y cirugia bucal, 2018, May-01, Volume: 23, Issue:3

Oral lichen planus (OLP) is a chronic inflammatory disease mediated by T cells, which manifests as reticular (white) or erosive (red) lesions, that are eventually painful. Oral lichenoid lesion (OLL) are distinguished from OLP by the presence of precipitating factors. The aim of this study was to evaluate whether the presence of metallothionein, which is involved in anti-apoptotic pathways and the anti-oxidative response, could serve as a differential diagnostic for OLP and OLL.. We evaluated the expression of metallothionein in 40 cases of OLP and 20 cases of OLL using immunohistochemistry.. White OLP has higher concentrations of metallothionein than red OLP in basal and parabasal layers. Moreover, metallothionein was more frequently observed in the cytoplasm and nuclei of basal cells in OLP patients compared to the same regions of OLL cases. Metallothionein levels are related to OLP severity and may contribute to a differential diagnosis between OLP and OLL.

Topics: Adult; Dental Amalgam; Diagnosis, Differential; Female; Humans; Lichen Planus, Oral; Male; Metallothionein; Middle Aged; Mouth Diseases

2018

Metallothionein, a marker of antiapoptosis, is associated with clinical forms of oral lichen planus.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2014, Volume: 43, Issue:10

To investigate the expression of anti- and proapoptosis markers, metallothionein (MT), and caspase-2, in the epithelial and inflammatory cells of oral lichen planus (OLP) patients, and to investigate the association with clinical parameters.. Included were biopsies of 70 OLP patients. The clinical data were collected from patients' charts. The expression of MT and caspase-2 was immunomorphometrically analyzed in the epithelial and inflammatory cells, and the results were correlated with the clinical presentation.. The epithelial and inflammatory cells expressed MT (10.2 ± 5.75 and 0.68 ± 0.86) and caspase-2 (1.54 ± 2.6 and 0.98 ± 1.15) which show a trend toward an inverse expression. The expression of MT in the epithelium was significantly higher in patients presenting with keratotic lichen planus than in patients with the atrophic and erosive forms (P = 0.0008). In the inflammatory cells, the expression of MT was inversely correlated with increasing age (R = 0.34, P = 0.0069).. The pattern of expression of MT and caspase-2 in OLP suggests an extensive antiapoptotic response in the keratotic form of the disease. Symptomatic patients may benefit from therapy targeted to apoptosis in the future.

Topics: Adult; Age Factors; Aged; Aged, 80 and over; Apoptosis; Apoptosis Regulatory Proteins; Biopsy; Caspase 2; Cohort Studies; Cysteine Endopeptidases; Double-Blind Method; Epithelial Cells; Female; Follow-Up Studies; Humans; Inflammation; Lichen Planus, Oral; Male; Metallothionein; Middle Aged; Mouth Mucosa; Retrospective Studies

2014