mesna and Mandibular-Neoplasms

Ewing's Sarcoma (ES) is a malignant tumor, which arises primarily in children. Most commonly found in the long bones and pelvis, it rarely is found in the bones of the face. This is a report of ES of the mandible in a nine-year-old Caucasian female. Treatment for this malignancy included an incisional biopsy, chemotherapy and radiotherapy protocol to the involved area in accordance with St. Christopher's Hospital and the Children's Hospital of Philadelphia. The patient is currently disease-free and has been for approximately five years.

Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Child; Cyclophosphamide; Disease-Free Survival; Doxorubicin; Female; Follow-Up Studies; Humans; Mandibular Neoplasms; Mesna; Neoadjuvant Therapy; Protective Agents; Radiotherapy, Adjuvant; Sarcoma, Ewing; Vincristine

Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cesarean Section; Chemotherapy, Adjuvant; Dacarbazine; Doxorubicin; Female; Histiocytoma, Benign Fibrous; Humans; Ifosfamide; Mandibular Neoplasms; Mesna; Pregnancy; Pregnancy Complications, Neoplastic

A patient underwent mandibular resection for high-grade osteosarcoma with immediate reconstruction with a microvascular fibula free bone graft and simultaneous placement of osseointegrated implants. Following initial healing, she underwent six cycles of chemotherapy and had further revision surgery prior to implant exposure and construction of a prosthesis. The chemotherapy appears to have had no deleterious effects on implant osseointegration or survival.

Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Transplantation; Cisplatin; Dacarbazine; Dental Care for Chronically Ill; Dental Implantation, Endosseous; Dental Implants; Doxorubicin; Female; Fibula; Humans; Ifosfamide; Mandibular Neoplasms; Mesna; Osseointegration; Osteosarcoma