mesna and Hemorrhagic-Disorders

mesna has been researched along with Hemorrhagic-Disorders* in 1 studies

Other Studies

1 other study(ies) available for mesna and Hemorrhagic-Disorders

ArticleYear
S-allyl cysteine ameliorates cyclophosphamide-induced downregulation of urothelial uroplakin IIIa with a concomitant effect on expression and release of CCL11and TNF-α in mice.
    Pharmacological reports : PR, 2018, Volume: 70, Issue:4

    The aim of this study was to evaluate the modulatory effect of S-allyl cysteine against cyclophosphamide-induced changes in uroplakin IIIa, CCL11 and TNF-α.. Mice were treated with cyclophosphamide (200mg/kg×7 d, ip). S-allyl cysteine (150mg/kg×7d, ip), and comparator compound mesna (40mg/kg×7d, ip) were administered 1h before and 4h after each cyclophosphamide dose. The urinary bladder was analysed for mRNA and protein changes in uroplakin IIIa (UPIIIa), CCL11 and TNF-α and histopathological findings.. Cyclophosphamide caused hemorrhagic cystitis formation and downregulation of UPIIIa. These changes were accompanied by upregulation of CCL11 and TNF-α. S-allyl cysteine attenuated these changes including protection at histological level. Mesna which was used as a comparator drug also showed protection. However, relatively S-allyl cysteine showed a stronger protective effect than mesna.. These findings highlight a correlation between downregulaion of UPIIIa and enhanced production of inflammatory biomarkers and protective effects of S-allyl cysteine which has been reported to be a potent uroprotective agent. The present study strengthens its role which could be clinically exploited in chemotherapy regimen.

    Topics: Animals; Chemokine CCL11; Cyclophosphamide; Cysteine; Cystitis; Down-Regulation; Hemorrhagic Disorders; Male; Mesna; Mice; Protective Agents; Tumor Necrosis Factor-alpha; Urinary Bladder; Uroplakin III

2018