mesna and Chest-Pain

Mediastinal angiosarcoma is a rare intrathoracic tumour and the therapeutic approach remains poorly codified.. We report the case of a 65-year-old female patient presenting with chest pain. Further exploration revealed an anterior mediastinal mass with pericardial invasion. Transthoracic biopsy gave the diagnosis of angiosarcoma. Multimodal treatment with neoadjuvant chemotherapy (doxorubicin 20 mg/m(2), Ifosfamide 2500 mg/m(2), Uromitexan® 2500 mg/m(2)) and surgery followed by adjuvant radiotherapy has led to remission of the tumour that has persisted for 12 months.. Systematic recording of such conditions in dedicated registries could contribute to enhance the description of the clinical and pathological characteristics, thus helping define the principles of specific management.

Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Chest Pain; Doxorubicin; Dyspnea; Female; Hemangiosarcoma; Humans; Ifosfamide; Magnetic Resonance Imaging; Mediastinal Neoplasms; Mesna; Neoadjuvant Therapy; Neoplasm Invasiveness; Positron-Emission Tomography; Radiotherapy, Adjuvant; Remission Induction; Tachycardia, Sinus; Tomography, X-Ray Computed; Weight Loss