mesalamine has been researched along with Sensitivity and Specificity in 26 studies
Mesalamine: An anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the active moiety of SULPHASALAZINE. (From Martindale, The Extra Pharmacopoeia, 30th ed)
mesalamine : A monohydroxybenzoic acid that is salicylic acid substituted by an amino group at the 5-position.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aims of this study were to examine the ability of the antioxidant N-acetylcysteine (NAC) and mesalamine (5-ASA) alone and in combination to affect TNBS-induced colitis in rat." | 7.73 | Antioxidant therapy with N-acetylcysteine plus mesalamine accelerates mucosal healing in a rodent model of colitis. ( Ancha, H; Harty, RF; Lightfoot, S; Siddiqui, A; Stewart, CA; Tedesco, D, 2006) |
| "The aims of this study were to examine the ability of the antioxidant N-acetylcysteine (NAC) and mesalamine (5-ASA) alone and in combination to affect TNBS-induced colitis in rat." | 3.73 | Antioxidant therapy with N-acetylcysteine plus mesalamine accelerates mucosal healing in a rodent model of colitis. ( Ancha, H; Harty, RF; Lightfoot, S; Siddiqui, A; Stewart, CA; Tedesco, D, 2006) |
| "Clinical trials in ulcerative colitis (UC) rely on certain parameters to evaluate responses that are highly subjective or of low sensitivity." | 2.78 | Evaluation of responsive gene expression as a sensitive and specific biomarker in patients with ulcerative colitis. ( Aceituno, M; Balsa, D; Esteller, M; Lozano, JJ; Merlos, M; Panés, J; Planell, N; Pontes, C; Román, J; Salas, A, 2013) |
| " Adverse events requiring the withdrawal of therapy seem to occur less frequently with balsalazide, mesalamine, and olsalazine compared with sulfasalazine." | 2.42 | The short- and long-term safety of 5-aminosalicylate products in the treatment of ulcerative colitis. ( Baker, DE; Kane, S, 2004) |
| "In this study, a new, fast and sensitive HPLC method with fluorometric detection was developed for the determination of mesalazine in human plasma and applied to a pharmacokinetic study." | 1.72 | Development of An HPLC Method for the Determination of Mesalazine in Human Plasma by Fluorimetric Derivatization and Application to A Prototype Pharmacokinetic Study. ( Ceylan, B; Önal, C; Tekkeli, EK, 2022) |
| " This study aimed to obtain the pharmacokinetic profiles, tissue distribution and plasma protein binding of C2 in Wistar Rats." | 1.43 | Pharmacokinetics in Wistar Rats of 5-[(4-Carboxybutanoyl)Amino]-2-Hydroxybenzoic Acid: A Novel Synthetic Derivative of 5-Aminosalicylic Acid (5-ASA) with Possible Anti-Inflammatory Activity. ( Correa-Basurto, J; Gutiérrez-Sánchez, M; Mendieta-Wejebe, JE; Padilla Martínez, II; Romero-Castro, A; Rosales Hernández, MC, 2016) |
| "Mesalamine adherence was quantified by patient self-reports at enrollment and pharmacy refills of mesalamine over 6 months." | 1.39 | A random urine test can identify patients at risk of mesalamine non-adherence: a prospective study. ( Berg, AH; Cheifetz, AS; Gifford, AE; Horowitz, G; Lahiff, C; Moss, AC, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (3.85) | 18.2507 |
| 2000's | 13 (50.00) | 29.6817 |
| 2010's | 10 (38.46) | 24.3611 |
| 2020's | 2 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Ceylan, B | 1 |
| Tekkeli, EK | 1 |
| Önal, C | 1 |
| Ohtaki, Y | 1 |
| Uchiyama, K | 1 |
| Kamiya, H | 1 |
| Moriizumi, E | 1 |
| Yamada, M | 1 |
| Aoki, Y | 1 |
| Watanabe, T | 1 |
| Kiryu, S | 1 |
| Suzuki, S | 1 |
| Matsumoto, Y | 1 |
| Ito, Z | 1 |
| Ohkusa, T | 1 |
| Koido, S | 1 |
| Saruta, M | 1 |
| Taxonera, C | 1 |
| Ponferrada, Á | 1 |
| Bermejo, F | 1 |
| Riestra, S | 1 |
| Saro, C | 1 |
| Martín-Arranz, MD | 1 |
| Cabriada, JL | 1 |
| Barreiro-de Acosta, M | 1 |
| de Castro, ML | 1 |
| López-Serrano, P | 1 |
| Barrio, J | 1 |
| Suarez, C | 1 |
| Iglesias, E | 1 |
| Argüelles-Arias, F | 1 |
| Ferrer, I | 1 |
| Marín-Jiménez, I | 1 |
| Hernández-Camba, A | 1 |
| Bastida, G | 1 |
| Van Domselaar, M | 1 |
| Martínez-Montiel, P | 1 |
| Olivares, D | 1 |
| Alba, C | 1 |
| Gisbert, JP | 1 |
| Yuksel, I | 1 |
| Kilincalp, S | 1 |
| Coskun, Y | 1 |
| Akinci, H | 1 |
| Hamamci, M | 1 |
| Alkan, A | 1 |
| Elbashir, AA | 1 |
| Altayib Alasha Abdalla, F | 1 |
| Aboul-Enein, HY | 1 |
| Nigović, B | 1 |
| Sadiković, M | 1 |
| Jurić, S | 1 |
| Romero-Castro, A | 1 |
| Gutiérrez-Sánchez, M | 1 |
| Correa-Basurto, J | 1 |
| Rosales Hernández, MC | 1 |
| Padilla Martínez, II | 1 |
| Mendieta-Wejebe, JE | 1 |
| Moussata, D | 1 |
| Allez, M | 1 |
| Cazals-Hatem, D | 1 |
| Treton, X | 1 |
| Laharie, D | 1 |
| Reimund, JM | 1 |
| Bertheau, P | 1 |
| Bourreille, A | 1 |
| Lavergne-Slove, A | 1 |
| Brixi, H | 1 |
| Branche, J | 1 |
| Gornet, JM | 1 |
| Stefanescu, C | 1 |
| Moreau, J | 1 |
| Marteau, P | 1 |
| Pelletier, AL | 1 |
| Carbonnel, F | 1 |
| Seksik, P | 1 |
| Simon, M | 1 |
| Fléjou, JF | 1 |
| Colombel, JF | 1 |
| Charlois, AL | 1 |
| Roblin, X | 1 |
| Nancey, S | 1 |
| Bouhnik, Y | 1 |
| Berger, F | 1 |
| Flourié, B | 1 |
| Pastorini, E | 1 |
| Locatelli, M | 1 |
| Simoni, P | 1 |
| Roda, G | 1 |
| Roda, E | 1 |
| Roda, A | 1 |
| Gu, GZ | 1 |
| Xia, HM | 1 |
| Pang, ZQ | 1 |
| Liu, ZY | 1 |
| Jiang, XG | 1 |
| Chen, J | 1 |
| Tursi, A | 1 |
| Elisei, W | 1 |
| Giorgetti, G | 1 |
| Aiello, F | 1 |
| Brandimarte, G | 1 |
| Román, J | 1 |
| Planell, N | 1 |
| Lozano, JJ | 1 |
| Aceituno, M | 1 |
| Esteller, M | 1 |
| Pontes, C | 1 |
| Balsa, D | 1 |
| Merlos, M | 1 |
| Panés, J | 1 |
| Salas, A | 1 |
| Gifford, AE | 1 |
| Berg, AH | 1 |
| Lahiff, C | 1 |
| Cheifetz, AS | 1 |
| Horowitz, G | 1 |
| Moss, AC | 1 |
| Annovazzi, A | 1 |
| Biancone, L | 1 |
| Caviglia, R | 1 |
| Chianelli, M | 1 |
| Capriotti, G | 1 |
| Mather, SJ | 1 |
| Caprilli, R | 1 |
| Pallone, F | 1 |
| Scopinaro, F | 1 |
| Signore, A | 1 |
| Teml, A | 1 |
| Kratzer, V | 1 |
| Schneider, B | 1 |
| Lochs, H | 1 |
| Norman, GL | 1 |
| Gangl, A | 1 |
| Vogelsang, H | 1 |
| Reinisch, W | 1 |
| Baker, DE | 1 |
| Kane, S | 1 |
| Allen, L | 1 |
| Weinberger, J | 1 |
| Weinberger, R | 1 |
| Palumbo, G | 1 |
| Bacchi, S | 1 |
| Primavera, L | 1 |
| Palumbo, P | 1 |
| Carlucci, G | 1 |
| Gorgulu, S | 1 |
| Yagci, G | 1 |
| Kaymakcioglu, N | 1 |
| Ozkara, M | 1 |
| Kurt, B | 1 |
| Ozcan, A | 1 |
| Kaya, O | 1 |
| Sadir, S | 1 |
| Tufan, T | 1 |
| Siddiqui, A | 1 |
| Ancha, H | 1 |
| Tedesco, D | 1 |
| Lightfoot, S | 1 |
| Stewart, CA | 1 |
| Harty, RF | 1 |
| Rácz, I | 1 |
| Jánoki, M | 1 |
| Kovács, V | 1 |
| Prantera, C | 1 |
| McCormack, PL | 1 |
| Robinson, DM | 1 |
| Perry, CM | 1 |
| Hussain, FN | 1 |
| Ajjan, RA | 1 |
| Moustafa, M | 1 |
| Anderson, JC | 1 |
| Riley, SA | 1 |
| Bystrowska, B | 1 |
| Nowak, J | 1 |
| Brandys, J | 1 |
| Gotti, R | 1 |
| Pomponio, R | 1 |
| Bertucci, C | 1 |
| Cavrini, V | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Double-blind, Randomised, Placebo and Mesalazine Controlled Phase II Study to Explore the Safety and Activity of Dersalazine in Patients With Mild to Moderate Active Colitis[NCT00808977] | Phase 2 | 80 participants (Anticipated) | Interventional | 2008-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for mesalamine and Sensitivity and Specificity
| Article | Year |
|---|---|
The short- and long-term safety of 5-aminosalicylate products in the treatment of ulcerative colitis.
Topics: Adolescent; Adult; Aminosalicylic Acids; Child; Clinical Trials as Topic; Colitis, Ulcerative; Dose- | 2004 |
Delayed-release Multi Matrix System (MMX) mesalazine in ulcerative colitis: a viewpoint by Cosimo Prantera.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Delayed-Action Preparations; Drug-Rela | 2007 |
Delayed-release Multi Matrix System (MMX) mesalazine: in ulcerative colitis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Delayed-Action Preparations; Drug Tole | 2007 |
4 trials available for mesalamine and Sensitivity and Specificity
| Article | Year |
|---|---|
Are random biopsies still useful for the detection of neoplasia in patients with IBD undergoing surveillance colonoscopy with chromoendoscopy?
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Colitis, Ulcerative; Colonoscopy; Colorectal | 2018 |
Evaluation of responsive gene expression as a sensitive and specific biomarker in patients with ulcerative colitis.
Topics: Adult; Aminosalicylic Acids; Anti-Inflammatory Agents, Non-Steroidal; Antigens, Differentiation; Azo | 2013 |
99mTc-interleukin-2 and (99m)Tc-HMPAO granulocyte scintigraphy in patients with inactive Crohn's disease.
Topics: Crohn Disease; Disease-Free Survival; Female; Granulocytes; Humans; Interleukin-2; Intestines; Male; | 2003 |
Anti-Saccharomyces cerevisiae antibodies: a stable marker for Crohn's disease during steroid and 5-aminosalicylic acid treatment.
Topics: Adolescent; Adult; Antibodies, Fungal; Biomarkers; Child; Crohn Disease; Enzyme-Linked Immunosorbent | 2003 |
19 other studies available for mesalamine and Sensitivity and Specificity
| Article | Year |
|---|---|
Development of An HPLC Method for the Determination of Mesalazine in Human Plasma by Fluorimetric Derivatization and Application to A Prototype Pharmacokinetic Study.
Topics: Chromatography, High Pressure Liquid; Fluorometry; Humans; Mesalamine; Pharmacokinetics; Sensitivity | 2022 |
The insoluble excretion of multi-matrix system mesalazine preparations in patients with ulcerative colitis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Humans; Mesalamine; Retrospective Stud | 2022 |
Early Tuberculin Skin Test for the Diagnosis of Latent Tuberculosis Infection in Patients with Inflammatory Bowel Disease.
Topics: Adult; Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Immunosuppressive Agent | 2017 |
Diagnostic accuracy of intestinal ultrasound and magnetic resonance enterography for the detection of endoscopy-based disease activity in ileocolonic Crohn's disease.
Topics: Adalimumab; Adolescent; Adult; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Az | 2019 |
Host-guest inclusion complex of mesalazine and β-cyclodextrin and spectrofluorometric determination of mesalazine.
Topics: beta-Cyclodextrins; Hydrogen-Ion Concentration; Mesalamine; Reproducibility of Results; Sensitivity | 2015 |
Electrochemical sensing of mesalazine and its N-acetylated metabolite in biological samples using functionalized carbon nanotubes.
Topics: Acetylation; Blood Chemical Analysis; Chromatography, High Pressure Liquid; Humans; Mesalamine; Micr | 2016 |
Pharmacokinetics in Wistar Rats of 5-[(4-Carboxybutanoyl)Amino]-2-Hydroxybenzoic Acid: A Novel Synthetic Derivative of 5-Aminosalicylic Acid (5-ASA) with Possible Anti-Inflammatory Activity.
Topics: Administration, Intravenous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High | 2016 |
Development and validation of a HPLC-ESI-MS/MS method for the determination of 5-aminosalicylic acid and its major metabolite N-acetyl-5-aminosalicylic acid in human plasma.
Topics: Aminosalicylic Acids; Calibration; Chromatography, High Pressure Liquid; Humans; Mesalamine; Referen | 2008 |
Determination of sulphasalazine and its main metabolite sulphapyridine and 5-aminosalicylic acid in human plasma by liquid chromatography/tandem mass spectrometry and its application to a pharmacokinetic study.
Topics: Chromatography, Liquid; Dimenhydrinate; Drug Stability; Humans; Linear Models; Mesalamine; Reproduci | 2011 |
Role of fecal calprotectin in the diagnosis and treatment of segmental colitis associated with diverticulosis.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Case-Control Studies; Colitis, Ulcerative | 2011 |
A random urine test can identify patients at risk of mesalamine non-adherence: a prospective study.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Biomarkers; Chromatography, | 2013 |
Determination of impurities in the drug 5-aminosalicylic acid by micellar electrokinetic capillary chromatography using an electrolyte pH that approaches the isoelectric point of the parent compound.
Topics: Chromatography, High Pressure Liquid; Chromatography, Micellar Electrokinetic Capillary; Electrolyte | 2004 |
A validated HPLC method with electrochemical detection for simultaneous assay of 5-aminosalicylic acid and its metabolite in human plasma.
Topics: Aminosalicylic Acids; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Chromatograp | 2005 |
Hyperbaric oxygen enhances the efficiency of 5-aminosalicylic acid in acetic acid-induced colitis in rats.
Topics: Acetic Acid; Animals; Colitis, Ulcerative; Combined Modality Therapy; Disease Models, Animal; Female | 2006 |
Antioxidant therapy with N-acetylcysteine plus mesalamine accelerates mucosal healing in a rodent model of colitis.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Biopsy, Needle; Coli | 2006 |
Measurement of small-bowel polyp size in patients with Peutz-Jeghers syndrome by using reference granules during video capsule endoscopy.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Capsule Endoscopy; Humans; Image Processing, Computer-Assis | 2007 |
Simple method for the determination of 5-aminosalicylic and N-acetyl-5-aminosalicylic acid in rectal tissue biopsies.
Topics: Aminosalicylic Acids; Anhydrides; Biopsy; Chemical Precipitation; Chromatography, High Pressure Liqu | 1998 |
Validation of a LC method for the determination of 5-aminosalicylic acid and its metabolite in plasma and urine.
Topics: Adult; Chromatography, High Pressure Liquid; Humans; Male; Mesalamine; Reference Values; Reproducibi | 2000 |
Determination of 5-aminosalicylic acid related impurities by micellar electrokinetic chromatography with an ion-pair reagent.
Topics: Chromatography, Micellar Electrokinetic Capillary; Indicators and Reagents; Ions; Mesalamine; Reprod | 2001 |