mesalamine has been researched along with Rheumatoid Arthritis in 23 studies
Mesalamine: An anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the active moiety of SULPHASALAZINE. (From Martindale, The Extra Pharmacopoeia, 30th ed)
mesalamine : A monohydroxybenzoic acid that is salicylic acid substituted by an amino group at the 5-position.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sulfasalazine is now an established 2nd line agent in the treatment of rheumatoid arthritis (RA) but its mode of action is unknown." | 7.67 | Sulfasalazine treatment and lymphocyte function in patients with rheumatoid arthritis. ( Bacon, PA; Farr, M; Salmon, M; Symmons, DP, 1988) |
| "We report a case of ulcerative colitis (UC) that occurred during the course of rheumatoid arthritis (RA)." | 5.32 | Ulcerative colitis occurring in the course of rheumatoid arthritis: a case successfully treated with mesalamine enema. ( Fukaya, E; Honma, F; Iwadate, H; Kobayashi, H; Orikasa, H; Saito, H; Sato, K; Sato, Y; Sekine, H; Shio, K; Shioya, Y; Sugisaki, K; Watanabe, H, 2004) |
| "The effects of sulfasalazine (SASP) and its metabolites sulfapyridine (SP) and 5-aminosalicylic acid (5-ASA) were investigated on release of prostaglandins (PG) and leukotrienes (LT) from synovial tissue of 37 patients with osteoarthritis, chondrocalcinosis and rheumatoid arthritis." | 3.68 | [Effect of sulfasalazine and its metabolites on prostaglandin and leukotriene liberation from human synovial tissue]. ( Kleemeyer, K; Peskar, BA; Peskar, BM; Wittenberg, HR, 1991) |
| "Despite the extensive use of sulfasalazine (SAS) and/or 5-aminosalicylic acid (5-ASA) in patients with inflammatory bowel disease and, more recently, rheumatoid arthritis, their mode of action has not been elucidated so far." | 3.67 | Possible mode of action of 5-aminosalicylic acid. ( Dreyling, KW; Goebell, H; May, B; Peskar, BM; Schaarschmidt, K, 1987) |
| "Sulfasalazine is now an established 2nd line agent in the treatment of rheumatoid arthritis (RA) but its mode of action is unknown." | 3.67 | Sulfasalazine treatment and lymphocyte function in patients with rheumatoid arthritis. ( Bacon, PA; Farr, M; Salmon, M; Symmons, DP, 1988) |
| "We assessed the in vitro effects of sulfasalazine and its 2 main metabolites, sulfapyridine (SP) and 5-aminosalicylic acid (5-ASA) on functional aspects of peripheral blood lymphocytes (PBM) of normal controls and patients with rheumatoid arthritis (RA)." | 3.67 | In vitro immunomodulatory effects of sulfasalazine and its metabolites. ( Comer, SS; Jasin, HE, 1988) |
| "We report a case of ulcerative colitis (UC) that occurred during the course of rheumatoid arthritis (RA)." | 1.32 | Ulcerative colitis occurring in the course of rheumatoid arthritis: a case successfully treated with mesalamine enema. ( Fukaya, E; Honma, F; Iwadate, H; Kobayashi, H; Orikasa, H; Saito, H; Sato, K; Sato, Y; Sekine, H; Shio, K; Shioya, Y; Sugisaki, K; Watanabe, H, 2004) |
| " Synovial tissue explants from RA patients secreted a decreased amount of the chemokines IL-8 and growth-related gene product alpha (GROalpha) when treated with SASP over a broad range of concentrations based on the typical clinical dosage of 2 g/day." | 1.31 | The effect of sulfasalazine on rheumatoid arthritic synovial tissue chemokine production. ( Campbell, PL; Connors, MA; Koch, AE; Volin, MV; Woodruff, DC, 2002) |
| "5-aminosalicylates are extensively prescribed for the treatment of ulcerative colitis but have a wide range of described adverse effects." | 1.31 | Sulphasalazine and mesalazine: serious adverse reactions re-evaluated on the basis of suspected adverse reaction reports to the Committee on Safety of Medicines. ( Langman, MJ; Ransford, RA, 2002) |
| "Cells were dosed with each compound for 24 h in the presence or absence of PMA inducer and messenger RNA (mRNA) extracted and subjected to Northern blot analysis." | 1.31 | Effects of sulfasalazine and its metabolites on steady state messenger RNA concentrations for inflammatory cytokines, matrix metalloproteinases, and tissue inhibitors of metalloproteinase in rheumatoid synovial fibroblasts. ( Blackburn, WD; Minghetti, PP, 2000) |
| "Nausea was a frequent problem in patients taking SP." | 1.27 | A study to determine the active moiety of sulphasalazine in rheumatoid arthritis. ( Astbury, C; Bird, HA; Hill, J; Le Gallez, P; Neumann, VC; Taggart, AJ, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (43.48) | 18.7374 |
| 1990's | 6 (26.09) | 18.2507 |
| 2000's | 5 (21.74) | 29.6817 |
| 2010's | 1 (4.35) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Knuckley, B | 1 |
| Luo, Y | 1 |
| Thompson, PR | 1 |
| Bansal, Y | 1 |
| Kaur, M | 1 |
| Silakari, O | 1 |
| Lee, AA | 1 |
| Gupta, S | 1 |
| Labban, M | 1 |
| Cao, FT | 1 |
| Trinh, QD | 1 |
| McNabb-Baltar, J | 1 |
| Volin, MV | 2 |
| Campbell, PL | 2 |
| Connors, MA | 1 |
| Woodruff, DC | 1 |
| Koch, AE | 2 |
| Ransford, RA | 1 |
| Langman, MJ | 1 |
| Sugisaki, K | 1 |
| Honma, F | 1 |
| Iwadate, H | 1 |
| Shio, K | 1 |
| Shioya, Y | 1 |
| Fukaya, E | 1 |
| Sato, K | 1 |
| Saito, H | 1 |
| Sekine, H | 1 |
| Kobayashi, H | 1 |
| Orikasa, H | 1 |
| Watanabe, H | 1 |
| Sato, Y | 1 |
| Sheldon, P | 2 |
| Pell, P | 1 |
| Engelhardt, K | 1 |
| Mohr, K | 1 |
| Harlow, LA | 1 |
| Woods, JM | 1 |
| Amin, MA | 1 |
| Tokuhira, M | 1 |
| Minghetti, PP | 1 |
| Blackburn, WD | 1 |
| Maier, KP | 1 |
| Wittenberg, HR | 1 |
| Kleemeyer, K | 1 |
| Peskar, BM | 2 |
| Peskar, BA | 1 |
| Madhok, R | 1 |
| Wijelath, E | 1 |
| Smith, J | 1 |
| Watson, J | 1 |
| Sturrock, RD | 1 |
| Capell, HA | 2 |
| Pullar, T | 1 |
| Hunter, JA | 1 |
| Dixon, JS | 2 |
| Neumann, VC | 2 |
| Taggart, AJ | 2 |
| Le Gallez, P | 2 |
| Astbury, C | 2 |
| Hill, J | 2 |
| Bird, HA | 1 |
| Lee, EJ | 1 |
| Ang, SB | 1 |
| Dreyling, KW | 1 |
| May, B | 1 |
| Schaarschmidt, K | 1 |
| Goebell, H | 1 |
| Symmons, DP | 1 |
| Salmon, M | 1 |
| Farr, M | 1 |
| Bacon, PA | 1 |
| Comer, SS | 1 |
| Jasin, HE | 1 |
| Webb, C | 1 |
| Grindulis, KA | 1 |
| Situnayake, RD | 1 |
| McConkey, B | 1 |
1 trial available for mesalamine and Rheumatoid Arthritis
| Article | Year |
|---|---|
Which component of sulphasalazine is active in rheumatoid arthritis?
Topics: Adult; Aged; Aminosalicylic Acids; Arthritis, Rheumatoid; Humans; Mesalamine; Middle Aged; Sulfanila | 1985 |
22 other studies available for mesalamine and Rheumatoid Arthritis
| Article | Year |
|---|---|
Profiling Protein Arginine Deiminase 4 (PAD4): a novel screen to identify PAD4 inhibitors.
Topics: Arthritis, Rheumatoid; Chlortetracycline; Combinatorial Chemistry Techniques; Enzyme Inhibitors; Flu | 2008 |
Benzimidazole--ibuprofen/mesalamine conjugates: potential candidates for multifactorial diseases.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Benzimidazoles; Edema; Ibup | 2015 |
Drug-induced acute pancreatitis due to medications used for inflammatory bowel disease: A VigiBase pharmacovigilance database study.
Topics: Acute Disease; Arthritis, Rheumatoid; Biological Products; Colitis, Ulcerative; Crohn Disease; Human | 2023 |
The effect of sulfasalazine on rheumatoid arthritic synovial tissue chemokine production.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; C | 2002 |
Sulphasalazine and mesalazine: serious adverse reactions re-evaluated on the basis of suspected adverse reaction reports to the Committee on Safety of Medicines.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Inju | 2002 |
Ulcerative colitis occurring in the course of rheumatoid arthritis: a case successfully treated with mesalamine enema.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Colitis, Ulcerative; Colon; C | 2004 |
Comparison of the effects of sulphasalazine, 5-aminosalicylic acid and sulphapyridine on the humoral response to antigen in vivo.
Topics: Administration, Oral; Aminosalicylic Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibo | 1995 |
[Mesalazine].
Topics: Aminosalicylic Acids; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Colitis, Ulcer | 1995 |
Treatment with sulfasalazine or sulfapyridine, but not 5-aminosalicyclic acid, inhibits basic fibroblast growth factor-induced endothelial cell chemotaxis.
Topics: Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Biocompatible | 1999 |
Effects of sulfasalazine and its metabolites on steady state messenger RNA concentrations for inflammatory cytokines, matrix metalloproteinases, and tissue inhibitors of metalloproteinase in rheumatoid synovial fibroblasts.
Topics: Arthritis, Rheumatoid; Cells, Cultured; Cytokines; Fibroblasts; Homeostasis; Humans; Inflammation Me | 2000 |
[Aminosalicylates in chronic inflammatory intestinal diseases and rheumatoid arthritis].
Topics: Aminosalicylic Acids; Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease; Humans; Mesalamine; | 1992 |
[Effect of sulfasalazine and its metabolites on prostaglandin and leukotriene liberation from human synovial tissue].
Topics: 6-Ketoprostaglandin F1 alpha; Aminosalicylic Acids; Anti-Inflammatory Agents, Non-Steroidal; Arthrit | 1991 |
Is the beneficial effect of sulfasalazine due to inhibition of synovial neovascularization?
Topics: Aminosalicylic Acids; Arthritis, Rheumatoid; Cell Division; Endothelium, Vascular; Humans; Mesalamin | 1991 |
Overlap between non-steroidal anti-inflammatory drugs (NSAIDs) and anti-rheumatoid drugs (ARDs).
Topics: Aminosalicylic Acids; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Auranofin; Aurothioglucose; G | 1985 |
A study to determine the active moiety of sulphasalazine in rheumatoid arthritis.
Topics: Adult; Aged; Aminosalicylic Acids; Arthritis, Rheumatoid; Female; Humans; Male; Mesalamine; Middle A | 1986 |
5-Aminosalicylic acid or sulphapyridine. Which is the active moiety of sulphasalazine in rheumatoid arthritis?
Topics: Adult; Aged; Aminosalicylic Acids; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; F | 1986 |
Simple and sensitive high-performance liquid chromatographic assay for 5-aminosalicylic acid and acetyl-5-aminosalicylic acid in serum.
Topics: Aminosalicylic Acids; Arthritis, Rheumatoid; Chromatography, High Pressure Liquid; Humans; Mesalamin | 1987 |
Possible mode of action of 5-aminosalicylic acid.
Topics: Aminosalicylic Acids; Arachidonic Acid; Arachidonic Acids; Arthritis, Rheumatoid; Colitis, Ulcerativ | 1987 |
Sulfasalazine treatment and lymphocyte function in patients with rheumatoid arthritis.
Topics: Aminosalicylic Acids; Arthritis, Rheumatoid; Cell Survival; Female; Humans; Lectins; Leukocyte Count | 1988 |
In vitro immunomodulatory effects of sulfasalazine and its metabolites.
Topics: Aminosalicylic Acids; Arthritis, Rheumatoid; Cell Division; Cells, Cultured; Humans; Immune System; | 1988 |
Effect of sulphasalazine and its metabolites on mitogen induced transformation of lymphocytes--clues to its clinical action?
Topics: Aminosalicylic Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cells | 1988 |
Resin-coated 5-aminosalicylic acid (Asacol) in rheumatoid arthritis.
Topics: Adult; Aged; Aminosalicylic Acids; Arthritis, Rheumatoid; Female; Humans; Male; Mesalamine; Middle A | 1985 |