Page last updated: 2024-10-30

mesalamine and Pregnancy

mesalamine has been researched along with Pregnancy in 71 studies

Mesalamine: An anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the active moiety of SULPHASALAZINE. (From Martindale, The Extra Pharmacopoeia, 30th ed)
mesalamine : A monohydroxybenzoic acid that is salicylic acid substituted by an amino group at the 5-position.

Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Research Excerpts

ExcerptRelevanceReference
"The Motherisk Program prospectively enrolled and followed up 165 women exposed to mesalamine during pregnancy, 146 of whom had first trimester exposure."9.08The safety of mesalamine in human pregnancy: a prospective controlled cohort study. ( Bologa, M; Diav-Citrin, O; Koren, G; Park, YH; Pastuszak, A; Polachek, H; Veerasuntharam, G, 1998)
"The Motherisk Program prospectively enrolled and followed up 165 women exposed to mesalamine during pregnancy, 146 of whom had first trimester exposure."5.08The safety of mesalamine in human pregnancy: a prospective controlled cohort study. ( Bologa, M; Diav-Citrin, O; Koren, G; Park, YH; Pastuszak, A; Polachek, H; Veerasuntharam, G, 1998)
" Mesalamine is considered safe in pregnancy, excluding formulations with dibutyl phthalate."5.05Mesalamine in the Initial Therapy of Ulcerative Colitis. ( Chibbar, R; Moss, AC, 2020)
"Non-adherence to mesalamine was underestimated by physicians in pregnant UC patients and contributed to disease relapse and possibly on pregnancy outcomes."4.02Non-adherence to Medications in Pregnant Ulcerative Colitis Patients Contributes to Disease Flares and Adverse Pregnancy Outcomes. ( Esaki, M; Fujii, T; Hibi, T; Hokari, R; Ishihara, S; Kitamura, K; Kobayashi, T; Kuji, N; Kunisaki, R; Miura, S; Nagahori, M; Naganuma, M; Nakamura, S; Sakuraba, A; Suzuki, Y; Takashi, K; Watanabe, C; Yamagami, H; Yokoyama, K; Yonezawa, M; Yoshimura, N, 2021)
" Because the patient was allergic to mesalazine, adalimumab (ADA) was used as maintenance therapy during pregnancy, following prednisolone as remission induction therapy."3.79Maintenance of the remission stage of Crohn's disease with adalimumab therapy during pregnancy. ( Ebi, M; Joh, T; Kamiya, T; Katano, T; Kataoka, H; Mizoshita, T; Mori, Y; Ozeki, K; Tanida, S; Tsukamoto, H, 2013)
"The drug is useful in the treatment of active ulcerative colitis as well as in preventing relapses of the disease in remission."3.75Sulfasalazine. Pharmacology, clinical use, toxicity, and related new drug development. ( Peppercorn, MA, 1984)
" We, therefore, conduct a randomized and controlled trial to evaluate the efficacy and safety of mesalazine enteric-coated tablets combined with Kangfuxin Liquid (KFX) enema for the child-bearing period female with active UC."3.01Effect of Kangfuxin Liquid enema combined with mesalazine on gestational outcomes and quality of life in child-bearing female with active ulcerative colitis: A protocol for randomized, double-blind, controlled trial. ( Li, F; Lu, H; Wang, T; Zhang, Q, 2021)
" As long-term administration of medications is often necessary, the safety of drug therapy during pregnancy and breast-feeding needs to be considered in daily clinical practice."2.50IBD medications during pregnancy and lactation. ( Hendel, J; Maxwell, C; Nielsen, OH, 2014)
"ulcerative colitis and Crohn's disease), for both active disease and the control of remission."2.44Drug insight: aminosalicylates for the treatment of IBD. ( Munck, LK; Nielsen, OH, 2007)
"Available data on Crohn's disease and pregnancy show that women with Crohn's disease can expect to conceive successfully, carry to term and deliver a healthy baby."2.44Pregnancy and breastfeeding in patients with Crohn's disease. ( Felley, C; Froehlich, F; Gonvers, JJ; Juillerat, P; Michetti, P; Mottet, C; Pittet, V; Vader, JP, 2007)
"The same drugs are used to treat hemorrhagic rectocolitis (HRC) and Crohn's disease (CD), although the aims are very different."2.44[Treatment of chronic inflammatory bowel diseases]. ( Lémann, M, 2007)
"Available data on Crohn's disease and pregnancy show that women with Crohn's disease can expect to conceive successfully, carry to term and deliver a healthy baby."2.43Pregnancy and Crohn's disease. ( Burnand, B; Felley, C; Froehlich, F; Gonvers, JJ; Juillerat, P; Michetti, P; Mottet, C; Vader, JP, 2005)
"Crohn's disease is a chronic inflammatory bowel disorder with a relapsing and remitting course."2.42Maintenance of remission in Crohn's disease: current and emerging therapeutic options. ( Brookes, MJ; Green, JR, 2004)
"Women with ulcerative colitis who are pregnant have many concerns, such as the effect of the gestational period on UC, the effect of UC on the pregnancy, and the safety of drugs used to control the disease."2.40[Ulcerative colitis and pregnancy]. ( Ida, A; Koyama, K, 1999)
"Pentasa-related adverse events were recorded from 1 January 1993 to 31 December 1994."2.39Adverse events in patients treated with 5-aminosalicyclic acid: 1993-1994 pharmacovigilance report for Pentasa in France. ( Devaux, C; Le Lu, M; Marteau, P; Nelet, F, 1996)
"Paternal and maternal use of 5-ASA was safe across offspring outcomes; none of the findings reached statistical significance."1.72The safety of paternal and maternal use of 5-aminosalicylic acid during conception and pregnancy: a nationwide cohort study. ( Friedman, S; Kjeldsen, J; Nielsen, J; Nørgård, BM, 2022)
"A pregnant woman with severe ulcerative colitis was treated with a dose of mesalazine 4,000 mg/day from early gestation to delivery."1.62Maternal mesalazine-induced neonatal gastrointestinal bleeding. ( Kuboi, T; Nii, K; Okada, H; Okazaki, K, 2021)
"Although severe flare of ulcerative colitis (UC) is uncommon, it significantly increases the risk of preterm delivery, low birth weight and other adverse fetal outcomes."1.46Case Report: Acute Flair of Ulcerative Colitis during Pregnancy Is Still a Major Problem. ( Markovic, S; Protic, M; Tarabar, D, 2017)
"Disease relapse was measured at each visit."1.43The Effects of Active IBD During Pregnancy in the Era of Novel IBD Therapies. ( de Lima-Karagiannis, A; van der Woude, CJ; Zelinkova-Detkova, Z, 2016)
"The prevalence rate of Crohn's disease and ulcerative colitis in our male infertile patients was 163 per 100,000 men and 490 per 100,000 men, respectively."1.40Inflammatory bowel disease in subfertile men and the effect of mesalazine on fertility. ( Arai, G; Iwahata, T; Kobori, Y; Okada, H; Shin, T; Soh, S; Suzuki, K; Yagi, H, 2014)
"Moderate-to-severe active extensive ulcerative colitis, unresponsive to mesalazine at 3."1.33Combined oral and topical mesalazine treatment for extensive ulcerative colitis. ( Cheifetz, AS; Moss, AC; Peppercorn, MA, 2006)
"Will pregnancy affect the disease? 4."1.30[Crohn's disease and pregnancy. A case report]. ( Gudiño Molina, FJ; Jinich Brook, H; Montiel-Jarquin, A; Rodríguez Torres, LF, 1998)
"We report the case of a man with ulcerative colitis in whom infertility and a markedly abnormal SPA were demonstrated while he was taking sulfasalazine."1.27Sulfasalazine-induced abnormal sperm penetration assay reversed on changing to 5-aminosalicylic acid enemas. ( Batzer, FR; Chatzinoff, M; Corson, SL; Friedman, LS; Guarino, JM, 1988)

Research

Studies (71)

TimeframeStudies, this research(%)All Research%
pre-19905 (7.04)18.7374
1990's16 (22.54)18.2507
2000's28 (39.44)29.6817
2010's13 (18.31)24.3611
2020's9 (12.68)2.80

Authors

AuthorsStudies
Nørgård, BM1
Friedman, S2
Kjeldsen, J1
Nielsen, J1
Avni-Biron, I1
Mishael, T1
Zittan, E1
Livne-Margolin, M1
Zinger, A1
Tzadok, R1
Goldenberg, R1
Kopylov, U1
Ron, Y1
Hadar, E1
Helman, S1
Granovsky, SG1
Ollech, JE1
Arazi, A1
Farkash, R1
Pauker, MH1
Yanai, H1
Dotan, I1
Shitrit, AB1
Bennett, A1
Horst, S1
Lee, S1
Seow, CH1
Adhikari, K1
Metcalfe, A1
Watanabe, C1
Nagahori, M1
Fujii, T1
Yokoyama, K1
Yoshimura, N1
Kobayashi, T1
Yamagami, H1
Kitamura, K1
Takashi, K1
Nakamura, S1
Naganuma, M1
Ishihara, S1
Esaki, M1
Yonezawa, M1
Kunisaki, R1
Sakuraba, A1
Kuji, N1
Miura, S1
Hibi, T1
Suzuki, Y1
Hokari, R1
Chibbar, R1
Moss, AC2
Wang, T1
Lu, H1
Li, F1
Zhang, Q1
Céruti, H1
Kayem, G1
Guilbaud, L1
Dussaux, C1
Gervais, A1
Beaufrère, A1
Coffin, B1
Mandelbrot, L1
Maisonneuve, E1
Nii, K1
Okazaki, K1
Okada, H3
Kuboi, T1
Ek, S1
Rosenborg, S1
Mizoshita, T1
Tanida, S1
Tsukamoto, H1
Ozeki, K1
Katano, T1
Ebi, M1
Mori, Y1
Kataoka, H1
Kamiya, T1
Joh, T1
Nielsen, OH2
Maxwell, C1
Hendel, J1
Ban, L1
Tata, LJ1
Fiaschi, L1
Card, T1
Källén, B1
Shin, T1
Kobori, Y1
Suzuki, K2
Iwahata, T1
Yagi, H1
Soh, S1
Arai, G1
D'Ovidio, V1
Meo, D1
Gozer, M1
Bazuro, ME1
Vernia, P1
de Lima-Karagiannis, A1
Zelinkova-Detkova, Z1
van der Woude, CJ1
Protic, M1
Markovic, S1
Tarabar, D1
Moum, B1
Hernández-Díaz, S2
Mitchell, AA2
Kelley, KE2
Calafat, AM2
Hauser, R2
Saha, S1
Esposti, SD1
Mountifield, RE1
Prosser, R1
Bampton, P1
Muller, K1
Andrews, JM1
Ye, BD1
Yang, SK1
Shin, SJ1
Lee, KM1
Jang, BI1
Cheon, JH1
Choi, CH1
Kim, YH1
Lee, H1
Su, YC1
Jang, YW1
Park, YS1
Kim, SH1
Jo, YJ1
Jo, YK1
Ahn, SB1
Seo, YS1
Hong, YO1
Tanaka, H1
Katoh, D1
Shimizu, M1
Ohno, T1
Tanaka, S1
Kanda, Y1
Nørgård, B2
Fonager, K1
Pedersen, L2
Jacobsen, BA1
Sørensen, HT2
Fleig, WE1
Fujimaru, K1
Taneichi, H1
Matsubara, K1
Takebe, N1
Ishida, W1
Kaneko, Y1
Sawada, A1
Fukusima, A1
Syouji, T1
Isurugi, C1
Kawahara, T1
Seki, H1
Oikawa, N1
Brookes, MJ1
Green, JR1
Mottet, C2
Juillerat, P2
Gonvers, JJ2
Froehlich, F2
Burnand, B1
Vader, JP2
Michetti, P3
Felley, C2
Marteau, P6
Seksik, P1
Couve, S1
Jian, R1
Caprilli, R1
Gassull, MA1
Escher, JC1
Moser, G1
Munkholm, P1
Forbes, A1
Hommes, DW1
Lochs, H1
Angelucci, E1
Cocco, A1
Vucelic, B1
Hildebrand, H1
Kolacek, S1
Riis, L1
Lukas, M1
de Franchis, R1
Hamilton, M1
Jantschek, G1
O'Morain, C1
Anwar, MM1
Freitas, JL1
Mouzas, IA1
Baert, F1
Mitchell, R1
Hawkey, CJ1
Cheifetz, AS1
Peppercorn, MA2
Makidono, C1
Takenaka, R1
Hiraoka, S1
Fujiwara, A1
Kato, J1
Kawahara, Y1
Kawamoto, H1
Mizuno, M1
Shiratori, Y1
Menzies, O1
Colls, B1
Munck, LK1
Christensen, LA3
Gottesleben, F1
Moffatt, DC1
Bernstein, CN1
Pittet, V1
Rahimi, R1
Nikfar, S1
Rezaie, A1
Abdollahi, M1
Lémann, M2
Colombel, JF1
Brabant, G1
Gubler, MC1
Locquet, A1
Comes, MC1
Dehennault, M1
Delcroix, M1
Devaux, CB1
Rasmussen, SN2
Hansen, SH2
Trallori, G1
d'Albasio, G1
Bardazzi, G1
Bonanomi, AG1
Amorosi, A1
Del Carlo, P1
Palli, D1
Galli, M1
Pacini, F1
Nelet, F1
Le Lu, M1
Devaux, C1
Cellier, C1
Bell, CM1
Habal, FM1
Diav-Citrin, O1
Park, YH1
Veerasuntharam, G1
Polachek, H1
Bologa, M1
Pastuszak, A1
Koren, G1
Botoman, VA1
Bonner, GF1
Botoman, DA1
Gudiño Molina, FJ1
Jinich Brook, H1
Montiel-Jarquin, A1
Rodríguez Torres, LF1
Tennenbaum, R2
Elefant, E2
Cosnes, J2
Sachar, D1
Saubermann, LJ1
Wolf, JL1
Rambaud, JC1
Modigliani, R1
Gendre, JP1
Cissoko, H1
Jonville-Béra, AP1
Lenain, H1
Rivière, MF1
Saugier, J1
Casanova, JL1
Autret-Leca, E1
Ida, A1
Koyama, K1
Stein, RB1
Hanauer, SB1
Katz, JA1
Pore, G1
Ward, VM1
Dua, S1
Morrison, GA1
Banatwala, N1
Shimamoto, M1
Takewaki, S1
Sakuraoka, S1
Nagasawa, T1
Kuroiwa, K1
Kodama, O1
Akatsuka, T1
Ambrosius Christensen, L1
Bondesen, S1
Hvidberg, EF1
Chatzinoff, M1
Guarino, JM1
Corson, SL1
Batzer, FR1
Friedman, LS1

Clinical Trials (6)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Counseling to Optimize Medication Adherence in Expectant Mothers With Inflammatory Bowel Disease (COACH-IBD)[NCT03091309]220 participants (Anticipated)Interventional2017-10-01Recruiting
Human Exposure to Bisphenol A, Phthalates and Fertility, Pregnancy Outcomes.[NCT00011713]1,474 participants (Actual)Observational1999-10-31Completed
The Effect of Sulfasalazine on CRH Levels in Pregnant Women With a History of Pre-Term Birth: A Randomized Controlled Trial[NCT05703425]Phase 250 participants (Anticipated)Interventional2023-03-01Recruiting
Synbiotic Treatment in Crohn's Disease Patients[NCT00305409]50 participants (Anticipated)Interventional2006-06-30Completed
MeSenteric SpAring Versus High Ligation Ileocolic Resection for the Prevention of REcurrent Crohn's DiseaSe (SPARES)[NCT04578392]181 participants (Anticipated)Interventional2020-07-28Recruiting
A Randomized, Controlled, Open-label Study to Assess the Efficacy of T2 Versus Azathioprine for the Maintenance of Clinical and Endoscopic Remission in Subjects With Crohn's Disease After Surgical Resection[NCT01015391]100 participants (Anticipated)Interventional2009-11-30Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

20 reviews available for mesalamine and Pregnancy

ArticleYear
Mesalamine in the Initial Therapy of Ulcerative Colitis.
    Gastroenterology clinics of North America, 2020, Volume: 49, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Dibutyl Phthalate; Drug Compounding; E

2020
IBD medications during pregnancy and lactation.
    Nature reviews. Gastroenterology & hepatology, 2014, Volume: 11, Issue:2

    Topics: Ciprofloxacin; Female; Glucocorticoids; Humans; Inflammatory Bowel Diseases; Lactation; Mesalamine;

2014
Reproductive issues in inflammatory bowel disease.
    Medicine and health, Rhode Island, 2009, Volume: 92, Issue:4

    Topics: Adaptation, Psychological; Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Azathio

2009
[For treatment decision the age to be taken into account. In Crohn's disease and ulcerative colitis attention to be paid to the age at manifestation].
    MMW Fortschritte der Medizin, 2009, May-07, Volume: 151, Issue:19

    Topics: Adolescent; Adult; Age Factors; Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroi

2009
Maintenance of remission in Crohn's disease: current and emerging therapeutic options.
    Drugs, 2004, Volume: 64, Issue:10

    Topics: Adjuvants, Immunologic; Adrenal Cortex Hormones; Animals; Anti-Bacterial Agents; Anti-Inflammatory A

2004
Pregnancy and Crohn's disease.
    Digestion, 2005, Volume: 71, Issue:1

    Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Crohn Disease; Drug Therapy

2005
Drug insight: aminosalicylates for the treatment of IBD.
    Nature clinical practice. Gastroenterology & hepatology, 2007, Volume: 4, Issue:3

    Topics: Aminosalicylic Acids; Anti-Inflammatory Agents, Non-Steroidal; Chemoprevention; Colitis, Ulcerative;

2007
Drug therapy for inflammatory bowel disease in pregnancy and the puerperium.
    Best practice & research. Clinical gastroenterology, 2007, Volume: 21, Issue:5

    Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antidiarrheals; Fe

2007
Pregnancy and breastfeeding in patients with Crohn's disease.
    Digestion, 2007, Volume: 76, Issue:2

    Topics: Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Breast Feeding; Crohn Disease; Drug

2007
Pregnancy outcome in women with inflammatory bowel disease following exposure to 5-aminosalicylic acid drugs: a meta-analysis.
    Reproductive toxicology (Elmsford, N.Y.), 2008, Volume: 25, Issue:2

    Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adult; Anti-Inflammatory Agents, Non-Steroidal;

2008
[Treatment of chronic inflammatory bowel diseases].
    Bulletin de l'Academie nationale de medecine, 2007, Volume: 191, Issue:6

    Topics: Adolescent; Adrenal Cortex Hormones; Adult; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Ste

2007
Sulfasalazine. Pharmacology, clinical use, toxicity, and related new drug development.
    Annals of internal medicine, 1984, Volume: 101, Issue:3

    Topics: Aminosalicylic Acids; Animals; Clinical Trials as Topic; Colitis, Ulcerative; Crohn Disease; Drug In

1984
Adverse events in patients treated with 5-aminosalicyclic acid: 1993-1994 pharmacovigilance report for Pentasa in France.
    Alimentary pharmacology & therapeutics, 1996, Volume: 10, Issue:6

    Topics: Aminosalicylic Acids; Anti-Inflammatory Agents, Non-Steroidal; Female; France; Humans; Mesalamine; P

1996
[Side effects of 5-aminosalicylic acid].
    Gastroenterologie clinique et biologique, 1997, Volume: 21, Issue:5

    Topics: Aminosalicylic Acids; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Inflammatory Bowel Di

1997
Management of inflammatory bowel disease.
    American family physician, 1998, Jan-01, Volume: 57, Issue:1

    Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ul

1998
[Ulcerative colitis and pregnancy].
    Nihon rinsho. Japanese journal of clinical medicine, 1999, Volume: 57, Issue:11

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Female; Fertility; Humans; Immu

1999
5-Aminosalicylic acid containing drugs. Delivery, fate, and possible clinical implications in man.
    Danish medical bulletin, 2000, Volume: 47, Issue:1

    Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Feces; Female; Humans; Injections, In

2000
Comparative tolerability of treatments for inflammatory bowel disease.
    Drug safety, 2000, Volume: 23, Issue:5

    Topics: Adrenal Cortex Hormones; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Female; Gas

2000
Inflammatory bowel disease and pregnancy.
    Inflammatory bowel diseases, 2001, Volume: 7, Issue:2

    Topics: Adult; Aminosalicylic Acids; Anti-Bacterial Agents; Colitis, Ulcerative; Crohn Disease; Female; Fert

2001
Salazopyrin and its newer analogues in the treatment of inflammatory bowel disease.
    JPMA. The Journal of the Pakistan Medical Association, 1985, Volume: 35, Issue:3

    Topics: Aminosalicylic Acids; Colitis, Ulcerative; Crohn Disease; Double-Blind Method; Drug Combinations; Dr

1985

Trials

4 trials available for mesalamine and Pregnancy

ArticleYear
Effect of Kangfuxin Liquid enema combined with mesalazine on gestational outcomes and quality of life in child-bearing female with active ulcerative colitis: A protocol for randomized, double-blind, controlled trial.
    Medicine, 2021, Feb-05, Volume: 100, Issue:5

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Double-Blind Method; Enema; Fem

2021
Sulfasalazine. Pharmacology, clinical use, toxicity, and related new drug development.
    Annals of internal medicine, 1984, Volume: 101, Issue:3

    Topics: Aminosalicylic Acids; Animals; Clinical Trials as Topic; Colitis, Ulcerative; Crohn Disease; Drug In

1984
5-Aminosalicylic acid in pregnancy: clinical report.
    The Italian journal of gastroenterology, 1994, Volume: 26, Issue:2

    Topics: Adult; Aminosalicylic Acids; Colitis, Ulcerative; Female; Fetus; Humans; Mesalamine; Pregnancy; Preg

1994
The safety of mesalamine in human pregnancy: a prospective controlled cohort study.
    Gastroenterology, 1998, Volume: 114, Issue:1

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Cohort Studies; Female; Humans; Inflammatory Bowel D

1998

Other Studies

48 other studies available for mesalamine and Pregnancy

ArticleYear
The safety of paternal and maternal use of 5-aminosalicylic acid during conception and pregnancy: a nationwide cohort study.
    Alimentary pharmacology & therapeutics, 2022, Volume: 56, Issue:9

    Topics: Child; Cohort Studies; Colitis, Ulcerative; Crohn Disease; Fathers; Female; Humans; Infant, Newborn;

2022
Ustekinumab during pregnancy in patients with inflammatory bowel disease: a prospective multicentre cohort study.
    Alimentary pharmacology & therapeutics, 2022, Volume: 56, Issue:9

    Topics: Biological Products; Chronic Disease; Female; Humans; Infant, Newborn; Inflammatory Bowel Diseases;

2022
Editorial: maternal and paternal 5-aminosalicylic acid use-safe in conception and pregnancy.
    Alimentary pharmacology & therapeutics, 2022, Volume: 56, Issue:9

    Topics: Female; Fertilization; Humans; Mesalamine; Pregnancy; Pregnancy Complications

2022
Pregnant women with IBD are more likely to be adherent to biologic therapies than other medications.
    Alimentary pharmacology & therapeutics, 2020, Volume: 51, Issue:5

    Topics: Adult; Biological Factors; Biological Therapy; Canada; Drug Prescriptions; Female; Humans; Inflammat

2020
Non-adherence to Medications in Pregnant Ulcerative Colitis Patients Contributes to Disease Flares and Adverse Pregnancy Outcomes.
    Digestive diseases and sciences, 2021, Volume: 66, Issue:2

    Topics: Abortion, Spontaneous; Adult; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Female;

2021
Intrahepatic cholestasis of pregnancy associated with azathioprine: A case series.
    Journal of gynecology obstetrics and human reproduction, 2021, Volume: 50, Issue:4

    Topics: Adult; Azathioprine; Bile Acids and Salts; Cholagogues and Choleretics; Cholestasis, Intrahepatic; C

2021
Maternal mesalazine-induced neonatal gastrointestinal bleeding.
    BMJ case reports, 2021, Apr-15, Volume: 14, Issue:4

    Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Female; Gast

2021
Mesalazine as a cause of fetal anemia and hydrops fetalis: A case report.
    Medicine, 2017, Volume: 96, Issue:50

    Topics: Anemia; Anti-Inflammatory Agents, Non-Steroidal; Erythrocyte Transfusion; Female; Fetal Diseases; Hu

2017
Maintenance of the remission stage of Crohn's disease with adalimumab therapy during pregnancy.
    Internal medicine (Tokyo, Japan), 2013, Volume: 52, Issue:10

    Topics: Adalimumab; Adult; Antibodies, Monoclonal, Humanized; Blood Component Removal; Colonoscopy; Combined

2013
Limited risks of major congenital anomalies in children of mothers with IBD and effects of medications.
    Gastroenterology, 2014, Volume: 146, Issue:1

    Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aminosalicylic Acids; Azathioprine; Congenital Abnormali

2014
Maternal use of 5-aminosalicylates in early pregnancy and congenital malformation risk in the offspring.
    Scandinavian journal of gastroenterology, 2014, Volume: 49, Issue:4

    Topics: Abnormalities, Drug-Induced; Adult; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Infant,

2014
Inflammatory bowel disease in subfertile men and the effect of mesalazine on fertility.
    Systems biology in reproductive medicine, 2014, Volume: 60, Issue:6

    Topics: Anti-Inflammatory Agents; Colitis, Ulcerative; Crohn Disease; Female; Fertility; Gastrointestinal Ag

2014
Ulcerative colitis and granulocyte-monocyte-apheresis: safety and efficacy of maintenance therapy during pregnancy.
    Journal of clinical apheresis, 2015, Volume: 30, Issue:1

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Combined Modality Therapy; Fema

2015
The Effects of Active IBD During Pregnancy in the Era of Novel IBD Therapies.
    The American journal of gastroenterology, 2016, Volume: 111, Issue:9

    Topics: Abortion, Spontaneous; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cohort Studies; Colitis, Ulce

2016
Case Report: Acute Flair of Ulcerative Colitis during Pregnancy Is Still a Major Problem.
    Digestive diseases (Basel, Switzerland), 2017, Volume: 35, Issue:1-2

    Topics: Adrenal Cortex Hormones; Adult; Colitis, Ulcerative; Disease Progression; Female; Humans; Infliximab

2017
Which are the 5-ASA compound side effects and how is it possible to avoid them?
    Inflammatory bowel diseases, 2008, Volume: 14 Suppl 2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Diarrhea; Dose-Response Relationship, Drug; Female; Humans;

2008
Medications as a potential source of exposure to phthalates in the U.S. population.
    Environmental health perspectives, 2009, Volume: 117, Issue:2

    Topics: Adolescent; Adult; Data Collection; Didanosine; Environmental Exposure; Female; Humans; Male; Mesala

2009
Pregnancy and IBD treatment: this challenging interplay from a patients' perspective.
    Journal of Crohn's & colitis, 2010, Volume: 4, Issue:2

    Topics: Adrenal Cortex Hormones; Adult; Anti-Inflammatory Agents; Azathioprine; Cross-Sectional Studies; Fem

2010
[Guidelines for the management of Crohn's disease].
    The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 2012, Volume: 59, Issue:2

    Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal; Antimetabolites, Antineoplastic; Budesonide; Crohn

2012
Medications as a potential source of exposure to phthalates among women of childbearing age.
    Reproductive toxicology (Elmsford, N.Y.), 2013, Volume: 37

    Topics: Adolescent; Adult; Amitriptyline; Drug Utilization; Environmental Exposure; Female; Humans; Mesalami

2013
[A case of Crohn's disease having normal delivery after infliximab treatment during early pregnancy].
    The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 2013, Jan-25, Volume: 61, Issue:1

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Capsule Endoscopy; Colon, Si

2013
[A case of neonatal severe hypereosinophilia associated with mesalazine administered during pregnancy].
    Arerugi = [Allergy], 2002, Volume: 51, Issue:12

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Female; Humans; Hypereosinophilic Synd

2002
Birth outcome in women exposed to 5-aminosalicylic acid during pregnancy: a Danish cohort study.
    Gut, 2003, Volume: 52, Issue:2

    Topics: Abnormalities, Drug-Induced; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cohort Studies; Colitis

2003
[Maintaining a remission].
    Zeitschrift fur Gastroenterologie, 2003, Volume: 41, Issue:1

    Topics: Administration, Oral; Adult; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti

2003
[Successful delivery in case of pregnancy with type 1 diabetes mellitus complicated by ulcerative colitis ].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2003, Aug-10, Volume: 92, Issue:8

    Topics: Adult; Betamethasone; Colitis, Ulcerative; Diabetes Mellitus, Type 1; Diet, Diabetic; Female; Humans

2003
Safety of high doses of mesalazine during pregnancy.
    The American journal of gastroenterology, 2005, Volume: 100, Issue:8

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Inflammatory Bowel Diseases; Mesalamine; Pr

2005
European evidence based consensus on the diagnosis and management of Crohn's disease: special situations.
    Gut, 2006, Volume: 55 Suppl 1

    Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Bone Diseases, Metabolic;

2006
European evidence based consensus on the diagnosis and management of Crohn's disease: special situations.
    Gut, 2006, Volume: 55 Suppl 1

    Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Bone Diseases, Metabolic;

2006
European evidence based consensus on the diagnosis and management of Crohn's disease: special situations.
    Gut, 2006, Volume: 55 Suppl 1

    Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Bone Diseases, Metabolic;

2006
European evidence based consensus on the diagnosis and management of Crohn's disease: special situations.
    Gut, 2006, Volume: 55 Suppl 1

    Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Bone Diseases, Metabolic;

2006
European evidence based consensus on the diagnosis and management of Crohn's disease: special situations.
    Gut, 2006, Volume: 55 Suppl 1

    Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Bone Diseases, Metabolic;

2006
European evidence based consensus on the diagnosis and management of Crohn's disease: special situations.
    Gut, 2006, Volume: 55 Suppl 1

    Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Bone Diseases, Metabolic;

2006
European evidence based consensus on the diagnosis and management of Crohn's disease: special situations.
    Gut, 2006, Volume: 55 Suppl 1

    Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Bone Diseases, Metabolic;

2006
European evidence based consensus on the diagnosis and management of Crohn's disease: special situations.
    Gut, 2006, Volume: 55 Suppl 1

    Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Bone Diseases, Metabolic;

2006
European evidence based consensus on the diagnosis and management of Crohn's disease: special situations.
    Gut, 2006, Volume: 55 Suppl 1

    Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Bone Diseases, Metabolic;

2006
Combined oral and topical mesalazine treatment for extensive ulcerative colitis.
    Nature clinical practice. Gastroenterology & hepatology, 2006, Volume: 3, Issue:5

    Topics: Administration, Oral; Administration, Topical; Adult; Anti-Inflammatory Agents, Non-Steroidal; Colit

2006
Therapeutic efficacy of leukocytapheresis in a pregnant woman with severe active ulcerative colitis.
    Digestion, 2006, Volume: 74, Issue:1

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Combined Modality Therapy; Fema

2006
Colitis and bronchiolitis obliterans organising pneumonia--the treatment or the disease?
    The New Zealand medical journal, 2006, Sep-08, Volume: 119, Issue:1241

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Bronchiolitis Obliterans; Colitis, Ulcerative; Femal

2006
Therapeutic drug use in women with Crohn's disease and birth outcomes: a Danish nationwide cohort study.
    The American journal of gastroenterology, 2007, Volume: 102, Issue:7

    Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Confidence Intervals; Congenital Abnorma

2007
[Crohn disease, exacerbated during pregnancy].
    Deutsche medizinische Wochenschrift (1946), 2007, Apr-20, Volume: 132, Issue:16

    Topics: Adult; Anti-Inflammatory Agents; Budesonide; Crohn Disease; Diagnosis, Differential; Drug Therapy, C

2007
Renal insufficiency in infant: side-effect of prenatal exposure to mesalazine?
    Lancet (London, England), 1994, Aug-27, Volume: 344, Issue:8922

    Topics: Adult; Aminosalicylic Acids; Crohn Disease; Female; Fetus; Humans; Infant; Kidney Diseases; Male; Me

1994
Mesalazine during pregnancy.
    Lancet (London, England), 1994, Dec-17, Volume: 344, Issue:8938

    Topics: Aminosalicylic Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Infant, Newb

1994
Disposition of 5-aminosalicylic acid and N-acetyl-5-aminosalicylic acid in fetal and maternal body fluids during treatment with different 5-aminosalicylic acid preparations.
    Acta obstetricia et gynecologica Scandinavica, 1994, Volume: 73, Issue:5

    Topics: Aminosalicylic Acids; Drug Monitoring; Female; Fetal Blood; Fetus; Humans; Inflammatory Bowel Diseas

1994
Safety of topical 5-aminosalicylic acid in pregnancy.
    The American journal of gastroenterology, 1997, Volume: 92, Issue:12

    Topics: Abnormalities, Drug-Induced; Administration, Topical; Adult; Anti-Inflammatory Agents, Non-Steroidal

1997
[Crohn's disease and pregnancy. A case report].
    Ginecologia y obstetricia de Mexico, 1998, Volume: 66

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Crohn Disease; Female; Humans; Infant, Newb

1998
Foetal outcome in women with inflammatory bowel disease treated during pregnancy with oral mesalazine microgranules.
    Alimentary pharmacology & therapeutics, 1998, Volume: 12, Issue:11

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Chi-Square Distribution; Drug Administration Schedul

1998
Exposure to mesalamine during pregnancy increased preterm deliveries (but not birth defects) and decreased birth weight.
    Gut, 1998, Volume: 43, Issue:3

    Topics: Abnormalities, Drug-Induced; Adult; Anti-Inflammatory Agents, Non-Steroidal; Birth Weight; Case-Cont

1998
Mesalamine: safe at first look.
    Inflammatory bowel diseases, 1999, Volume: 5, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cohort Studies; Female; Humans; Inflammatory Bowel Diseases

1999
[Pregnancy outcome in inflammatory bowel diseases].
    Gastroenterologie clinique et biologique, 1999, Volume: 23, Issue:5

    Topics: Aminosalicylic Acids; Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Crohn Disease; Female;

1999
[Agranulocytosis and transitory immune deficiency after fetal exposure to azathioprine and mesalazine].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 1999, Volume: 6, Issue:10

    Topics: Adult; Agammaglobulinemia; Agranulocytosis; Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; C

1999
Management of inflammatory bowel disease during pregnancy and nursing.
    Seminars in gastrointestinal disease, 2001, Volume: 12, Issue:4

    Topics: Adult; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Breast Feeding; Ce

2001
Oro-facial granulomatosis: a laryngeal presentation.
    The Journal of laryngology and otology, 2001, Volume: 115, Issue:11

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Colonic Diseases; Female; Granuloma, Laryngeal; Huma

2001
Balsalazide disodium.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2002, Jan-01, Volume: 59, Issue:1

    Topics: Aminosalicylic Acids; Anti-Ulcer Agents; Colitis, Ulcerative; Drug Interactions; Female; Humans; Mal

2002
Use of L-leucyl-3-carboxy-4-hydroxyanilide as substrate for determining the activity of microsomal aminopeptidase in serum.
    Clinical chemistry, 1985, Volume: 31, Issue:10

    Topics: Aminopeptidases; Aminosalicylic Acids; Anilides; Biliary Tract Diseases; CD13 Antigens; Chromogenic

1985
Salazosulfapyridine and metabolites in fetal and maternal body fluids with special reference to 5-aminosalicylic acid.
    Acta obstetricia et gynecologica Scandinavica, 1987, Volume: 66, Issue:5

    Topics: Adult; Aminosalicylic Acids; Body Fluids; Female; Fetus; Humans; Maternal-Fetal Exchange; Mesalamine

1987
Sulfasalazine-induced abnormal sperm penetration assay reversed on changing to 5-aminosalicylic acid enemas.
    Digestive diseases and sciences, 1988, Volume: 33, Issue:1

    Topics: Adult; Aminosalicylic Acids; Colitis, Ulcerative; Enema; Female; Humans; Infant, Newborn; Infertilit

1988