Page last updated: 2024-10-30

mesalamine and Pouchitis

mesalamine has been researched along with Pouchitis in 7 studies

Mesalamine: An anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the active moiety of SULPHASALAZINE. (From Martindale, The Extra Pharmacopoeia, 30th ed)
mesalamine : A monohydroxybenzoic acid that is salicylic acid substituted by an amino group at the 5-position.

Pouchitis: Acute INFLAMMATION in the INTESTINAL MUCOSA of the continent ileal reservoir (or pouch) in patients who have undergone ILEOSTOMY and restorative proctocolectomy (PROCTOCOLECTOMY, RESTORATIVE).

Research Excerpts

ExcerptRelevanceReference
"To test the hypothesis that sulfasalazine (SASP) might have a synergistic beneficial effect in acute pouchitis, by combining the anti-inflammatory activity of 5-aminosalicylic Acid and the bacteriostatic effect of sulphapyridine."9.14Pilot study: the use of sulfasalazine for the treatment of acute pouchitis. ( Belluzzi, A; Bianchi, ML; Castellani, L; Grazia, M; Roda, E; Roda, G; Rosati, G; Serrani, M; Ugolini, G, 2010)
"To test the hypothesis that sulfasalazine (SASP) might have a synergistic beneficial effect in acute pouchitis, by combining the anti-inflammatory activity of 5-aminosalicylic Acid and the bacteriostatic effect of sulphapyridine."5.14Pilot study: the use of sulfasalazine for the treatment of acute pouchitis. ( Belluzzi, A; Bianchi, ML; Castellani, L; Grazia, M; Roda, E; Roda, G; Rosati, G; Serrani, M; Ugolini, G, 2010)
"Treatment of pouchitis is largely empirical and few controlled studies have been carried-out."2.41Review article: treatment of mild to moderate ulcerative colitis and pouchitis. ( Amadini, C; Campieri, M; Gionchetti, P; Rizzello, F; Venturi, A, 2002)
"The incidence of PPI in patients with ulcerative colitis/indeterminate colitis is 5."1.35Incidence and short-term implications of prepouch ileitis following restorative proctocolectomy with ileal pouch-anal anastomosis for ulcerative colitis. ( Bell, AJ; Ciclitira, PJ; Clark, SK; McLaughlin, SD; Nicholls, RJ; Tekkis, PP, 2009)
"Firstly we used ciprofloxacin to treat pouchitis."1.33Diffuse gastroduodenitis and pouchitis associated with ulcerative colitis. ( Hori, K; Ikeuchi, H; Kaibe, N; Nakamura, M; Nakano, H; Nishigami, T; Noda, M; Uchino, M; Yamamura, T; Yanagi, H, 2006)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (71.43)29.6817
2010's2 (28.57)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Andersson, P1
Norblad, R1
Söderholm, JD1
Myrelid, P1
McLaughlin, SD1
Clark, SK1
Bell, AJ1
Tekkis, PP1
Ciclitira, PJ1
Nicholls, RJ1
Belluzzi, A1
Serrani, M1
Roda, G1
Bianchi, ML1
Castellani, L1
Grazia, M1
Rosati, G1
Ugolini, G1
Roda, E1
Matthes, H1
Moser, G1
Jantschek, G1
Böhm, S1
Kruis, W1
Ikeuchi, H1
Hori, K1
Nishigami, T1
Nakano, H1
Uchino, M1
Nakamura, M1
Kaibe, N1
Noda, M1
Yanagi, H1
Yamamura, T1
Gionchetti, P1
Amadini, C1
Rizzello, F1
Venturi, A1
Campieri, M1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Randomized, Double-Blind, Placebo-Controlled Study of VSL#3 Versus Placebo in the Maintenance of Remission in Crohn's Disease[NCT00114465]Phase 438 participants (Actual)Interventional2005-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for mesalamine and Pouchitis

ArticleYear
[Probiotics in chronic inflammatory bowel disease].
    MMW Fortschritte der Medizin, 2006, Aug-31, Volume: 148, Issue:35-36

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Bifidobacterium; Colitis, Ulcerative; Crohn Disease; Escher

2006
Review article: treatment of mild to moderate ulcerative colitis and pouchitis.
    Alimentary pharmacology & therapeutics, 2002, Volume: 16 Suppl 4

    Topics: Administration, Oral; Administration, Rectal; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-

2002

Trials

1 trial available for mesalamine and Pouchitis

ArticleYear
Pilot study: the use of sulfasalazine for the treatment of acute pouchitis.
    Alimentary pharmacology & therapeutics, 2010, Jan-15, Volume: 31, Issue:2

    Topics: Adult; Colonic Pouches; Female; Humans; Intestinal Mucosa; Male; Mesalamine; Middle Aged; Pilot Proj

2010

Other Studies

4 other studies available for mesalamine and Pouchitis

ArticleYear
Ileorectal anastomosis in comparison with ileal pouch anal anastomosis in reconstructive surgery for ulcerative colitis--a single institution experience.
    Journal of Crohn's & colitis, 2014, Volume: 8, Issue:7

    Topics: Abdominal Neoplasms; Adenocarcinoma; Adolescent; Adrenal Cortex Hormones; Adult; Anastomosis, Surgic

2014
Incidence and short-term implications of prepouch ileitis following restorative proctocolectomy with ileal pouch-anal anastomosis for ulcerative colitis.
    Diseases of the colon and rectum, 2009, Volume: 52, Issue:5

    Topics: Adult; Aged; Anti-Infective Agents; Anti-Inflammatory Agents; Budesonide; Ciprofloxacin; Colitis, Ul

2009
[Ulcerative colitis. Complementary therapies].
    Zeitschrift fur Gastroenterologie, 2004, Volume: 42, Issue:9

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Child; Colitis, Ulcerative; Complementary Therapies;

2004
Diffuse gastroduodenitis and pouchitis associated with ulcerative colitis.
    World journal of gastroenterology, 2006, Sep-28, Volume: 12, Issue:36

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Duodenitis; Female; Gastritis;

2006