mesalamine has been researched along with Microsatellite Instability in 2 studies
Mesalamine: An anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the active moiety of SULPHASALAZINE. (From Martindale, The Extra Pharmacopoeia, 30th ed)
mesalamine : A monohydroxybenzoic acid that is salicylic acid substituted by an amino group at the 5-position.
Microsatellite Instability: The occurrence of highly polymorphic mono- and dinucleotide MICROSATELLITE REPEATS in somatic cells. It is a form of genome instability associated with defects in DNA MISMATCH REPAIR.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Lynch syndrome is caused by germline mutations in DNA mismatch repair genes leading to microsatellite instability (MSI) and colorectal cancer." | 1.42 | Mesalazine and thymoquinone attenuate intestinal tumour development in Msh2(loxP/loxP) Villin-Cre mice. ( Campregher, C; Edelmann, W; Evstatiev, R; Gasche, C; Khare, V; Kortüm, B; Kucherlapati, MH; Lang, M; Mittlböck, M; Pinter, M; Scharl, T; Schmid, G, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kortüm, B | 1 |
| Campregher, C | 1 |
| Lang, M | 1 |
| Khare, V | 1 |
| Pinter, M | 1 |
| Evstatiev, R | 2 |
| Schmid, G | 1 |
| Mittlböck, M | 1 |
| Scharl, T | 1 |
| Kucherlapati, MH | 1 |
| Edelmann, W | 1 |
| Gasche, C | 2 |
| Goel, A | 1 |
| Mittal, A | 1 |
| Nemeth, M | 1 |
| Kruis, W | 1 |
| Stolte, M | 1 |
| Boland, CR | 1 |
1 trial available for mesalamine and Microsatellite Instability
| Article | Year |
|---|---|
In vivo effects of mesalazine or E. coli Nissle 1917 on microsatellite instability in ulcerative colitis.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Colitis, Ulcerative; Colon; Double-Bli | 2009 |
1 other study available for mesalamine and Microsatellite Instability
| Article | Year |
|---|---|
Mesalazine and thymoquinone attenuate intestinal tumour development in Msh2(loxP/loxP) Villin-Cre mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoquinones; Cell Proliferation; Colorectal Neop | 2015 |