mesalamine has been researched along with Genetic Predisposition in 13 studies
Mesalamine: An anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the active moiety of SULPHASALAZINE. (From Martindale, The Extra Pharmacopoeia, 30th ed)
mesalamine : A monohydroxybenzoic acid that is salicylic acid substituted by an amino group at the 5-position.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Crohn's disease (CD) and ulcerative colitis (UC) are common and heterogeneous chronic inflammatory bowel disorders of childhood that account for up to 25% of all patients with inflammatory bowel disease (IBD)." | 2.43 | Inflammatory bowel disease in children: a pediatrician's perspective. ( Cuffari, C, 2006) |
| "According to the current paradigm both ulcerative colitis (UC) and Crohn's disease (CD) result from a complex interplay of genetic susceptibility factors, environmental factors, alterations of the physiological intestinal flora and a defective regulation of the intestinal immune system." | 2.42 | Current concept of pathophysiological understanding and natural course of ulcerative colitis. ( Galle, PR; Holtmann, MH, 2004) |
| "Despite NUDT15 variants showing significant association with thiopurine-induced adverse events (AEs) in Asians, it remains unclear which variants of NUDT15 or whether additional genetic variants should be tested to predict AEs." | 1.48 | NUDT15 codon 139 is the best pharmacogenetic marker for predicting thiopurine-induced severe adverse events in Japanese patients with inflammatory bowel disease: a multicenter study. ( Andoh, A; Araki, H; Endo, K; Hanai, H; Hiraoka, S; Hisamatsu, T; Hokari, R; Ikeya, K; Ishiguro, Y; Kakuta, Y; Kawai, Y; Kinouchi, Y; Kobayashi, T; Masamune, A; Matsumoto, T; Miura, M; Mizuno, S; Moroi, R; Motoya, S; Naganuma, M; Nagasaki, M; Naito, T; Nakagawa, S; Nakagawa, T; Nakamura, S; Nakase, H; Nishida, A; Okamoto, D; Onodera, K; Sakuraba, H; Sasaki, M; Shiga, H; Shimosegawa, T; Shinozaki, M; Suzuki, Y; Takagawa, T; Takahara, M; Toyonaga, T; Yanai, S, 2018) |
| "A total of 174 patients with ulcerative colitis, 99 women and 75 men, were included." | 1.40 | IL23R polymorphisms influence phenotype and response to therapy in patients with ulcerative colitis. ( Brito, M; Correia, LA; Cravo, ML; de Deus, JR; Ferreira, PA; Maio, RF; Ministro, P; Moura-Santos, P; Peixe, P; Sousa, P; Tavares, L; Velho, S; Velosa, JF, 2014) |
| "We report a case of the daughter with ulcerative colitis and her mother with Crohn's disease who have a -159C/T promoter polymorphism of CD14 gene for IBD." | 1.36 | [A case of ulcerative colitis found in a patient whose parent has Crohn's disease]. ( Chang, UI; Chung, WC; Jung, SH; Kim, JD; Kwak, JW; Lee, KM; Paik, CN; Yang, JM, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (30.77) | 29.6817 |
| 2010's | 8 (61.54) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Moreno Moraleda, I | 1 |
| Lázaro Sáez, M | 1 |
| Diéguez Castillo, C | 1 |
| Hernández Martínez, Á | 1 |
| Hosseinpour, Z | 1 |
| Salehi, Z | 1 |
| Talesh Sasani, S | 1 |
| Aminian, K | 1 |
| Kakuta, Y | 1 |
| Kawai, Y | 1 |
| Okamoto, D | 1 |
| Takagawa, T | 1 |
| Ikeya, K | 1 |
| Sakuraba, H | 1 |
| Nishida, A | 1 |
| Nakagawa, S | 1 |
| Miura, M | 1 |
| Toyonaga, T | 1 |
| Onodera, K | 1 |
| Shinozaki, M | 1 |
| Ishiguro, Y | 1 |
| Mizuno, S | 1 |
| Takahara, M | 1 |
| Yanai, S | 1 |
| Hokari, R | 1 |
| Nakagawa, T | 1 |
| Araki, H | 1 |
| Motoya, S | 1 |
| Naito, T | 1 |
| Moroi, R | 1 |
| Shiga, H | 1 |
| Endo, K | 1 |
| Kobayashi, T | 1 |
| Naganuma, M | 1 |
| Hiraoka, S | 1 |
| Matsumoto, T | 1 |
| Nakamura, S | 1 |
| Nakase, H | 1 |
| Hisamatsu, T | 1 |
| Sasaki, M | 1 |
| Hanai, H | 1 |
| Andoh, A | 1 |
| Nagasaki, M | 1 |
| Kinouchi, Y | 1 |
| Shimosegawa, T | 1 |
| Masamune, A | 1 |
| Suzuki, Y | 1 |
| Cravo, ML | 1 |
| Ferreira, PA | 1 |
| Sousa, P | 1 |
| Moura-Santos, P | 1 |
| Velho, S | 1 |
| Tavares, L | 1 |
| de Deus, JR | 1 |
| Ministro, P | 1 |
| Peixe, P | 1 |
| Correia, LA | 1 |
| Velosa, JF | 1 |
| Maio, RF | 1 |
| Brito, M | 1 |
| Galatola, M | 1 |
| Miele, E | 1 |
| Strisciuglio, C | 1 |
| Paparo, L | 1 |
| Rega, D | 1 |
| Delrio, P | 1 |
| Duraturo, F | 1 |
| Martinelli, M | 1 |
| Rossi, GB | 1 |
| Staiano, A | 1 |
| Izzo, P | 1 |
| De Rosa, M | 1 |
| Greenstein, RJ | 1 |
| Cameron, DW | 1 |
| Brown, ST | 1 |
| Pardi, DS | 1 |
| Kwak, JW | 1 |
| Lee, KM | 1 |
| Chung, WC | 1 |
| Paik, CN | 1 |
| Chang, UI | 1 |
| Kim, JD | 1 |
| Jung, SH | 1 |
| Yang, JM | 1 |
| Cheng, SX | 1 |
| Raizner, A | 1 |
| Phatak, UP | 1 |
| Cho, JH | 1 |
| Pashankar, DS | 1 |
| Holtmann, MH | 1 |
| Galle, PR | 1 |
| Cuffari, C | 1 |
| Hausmann, M | 1 |
| Paul, G | 1 |
| Menzel, K | 1 |
| Brunner-Ploss, R | 1 |
| Falk, W | 1 |
| Schölmerich, J | 1 |
| Herfarth, H | 1 |
| Rogler, G | 1 |
| Abdo, AA | 1 |
| Zetler, PJ | 1 |
| Halparin, LS | 1 |
3 reviews available for mesalamine and Genetic Predisposition
| Article | Year |
|---|---|
Diagnosis and Management of Microscopic Colitis.
Topics: Anion Exchange Resins; Anti-Inflammatory Agents, Non-Steroidal; Antidiarrheals; Autoimmunity; Bile A | 2017 |
Current concept of pathophysiological understanding and natural course of ulcerative colitis.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colect | 2004 |
Inflammatory bowel disease in children: a pediatrician's perspective.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites; Child; Colitis, Ulcerative; Environment; G | 2006 |
10 other studies available for mesalamine and Genetic Predisposition
| Article | Year |
|---|---|
Inflammatory bowel disease and inherited colorectal cancer: Is there a genetic link?
Topics: Adenocarcinoma; Adult; Age of Onset; Anti-Inflammatory Agents; Azathioprine; Breast Neoplasms; Colit | 2021 |
p53 and miR-34b/c genetic variation and their impact on ulcerative colitis susceptibility.
Topics: Adult; Alleles; Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Colitis, Ulcerative; | 2018 |
NUDT15 codon 139 is the best pharmacogenetic marker for predicting thiopurine-induced severe adverse events in Japanese patients with inflammatory bowel disease: a multicenter study.
Topics: Alopecia; Antibodies, Monoclonal; Azathioprine; Biomarkers, Pharmacological; Genetic Predisposition | 2018 |
IL23R polymorphisms influence phenotype and response to therapy in patients with ulcerative colitis.
Topics: Adrenal Cortex Hormones; Adult; Age Factors; Anti-Inflammatory Agents; Antibodies, Monoclonal; Azath | 2014 |
Synergistic effect of interleukin-10-receptor variants in a case of early-onset ulcerative colitis.
Topics: Adenomatous Polyposis Coli; Age of Onset; Anti-Infective Agents; Azathioprine; beta Catenin; Biomark | 2013 |
"Add-on" is scientifically more accurate than "placebo control" in multiple inflammatory bowel disease (IBD) trials.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Genetic Predisposition to Disease | 2014 |
[A case of ulcerative colitis found in a patient whose parent has Crohn's disease].
Topics: Colitis, Ulcerative; Colonoscopy; Crohn Disease; Female; Genetic Predisposition to Disease; Humans; | 2010 |
Celiac disease in a child with ulcerative colitis: a possible genetic association.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Celiac Disease; Child; Colitis, Ulcerative; Diet, Gluten-Fr | 2013 |
NAT1 genotypes do not predict response to mesalamine in patients with ulcerative colitis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arylamine N-Acetyltransferase; Colitis, Ulcerative; Genetic | 2008 |
Familial microscopic colitis.
Topics: Abdominal Pain; Adult; Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Colitis; Colonoscopy; Consti | 2001 |