mesalamine has been researched along with Colorectal Neoplasms, Hereditary Nonpolyposis in 1 studies
Mesalamine: An anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the active moiety of SULPHASALAZINE. (From Martindale, The Extra Pharmacopoeia, 30th ed)
mesalamine : A monohydroxybenzoic acid that is salicylic acid substituted by an amino group at the 5-position.
Colorectal Neoplasms, Hereditary Nonpolyposis: A group of autosomal-dominant inherited diseases in which COLON CANCER arises in discrete adenomas. Unlike FAMILIAL POLYPOSIS COLI with hundreds of polyps, hereditary nonpolyposis colorectal neoplasms occur much later, in the fourth and fifth decades. HNPCC has been associated with germline mutations in mismatch repair (MMR) genes. It has been subdivided into Lynch syndrome I or site-specific colonic cancer, and LYNCH SYNDROME II which includes extracolonic cancer.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Lynch syndrome is caused by germline mutations in DNA mismatch repair genes leading to microsatellite instability (MSI) and colorectal cancer." | 1.42 | Mesalazine and thymoquinone attenuate intestinal tumour development in Msh2(loxP/loxP) Villin-Cre mice. ( Campregher, C; Edelmann, W; Evstatiev, R; Gasche, C; Khare, V; Kortüm, B; Kucherlapati, MH; Lang, M; Mittlböck, M; Pinter, M; Scharl, T; Schmid, G, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kortüm, B | 1 |
| Campregher, C | 1 |
| Lang, M | 1 |
| Khare, V | 1 |
| Pinter, M | 1 |
| Evstatiev, R | 1 |
| Schmid, G | 1 |
| Mittlböck, M | 1 |
| Scharl, T | 1 |
| Kucherlapati, MH | 1 |
| Edelmann, W | 1 |
| Gasche, C | 1 |
1 other study available for mesalamine and Colorectal Neoplasms, Hereditary Nonpolyposis
| Article | Year |
|---|---|
Mesalazine and thymoquinone attenuate intestinal tumour development in Msh2(loxP/loxP) Villin-Cre mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoquinones; Cell Proliferation; Colorectal Neop | 2015 |