Page last updated: 2024-10-30

mesalamine and Colitis

mesalamine has been researched along with Colitis in 223 studies

Mesalamine: An anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the active moiety of SULPHASALAZINE. (From Martindale, The Extra Pharmacopoeia, 30th ed)
mesalamine : A monohydroxybenzoic acid that is salicylic acid substituted by an amino group at the 5-position.

Colitis: Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.

Research Excerpts

ExcerptRelevanceReference
"Pericarditis should be considered in any patient complaining of chest pain and/or dyspnea who is taking a product that contains mesalamine or sulfasalazine."8.81Possible mesalamine-induced pericarditis: case report and literature review. ( Malinowski, JM; Waite, RA, 2002)
"Mesalamine and/or cholestyramine may be effective for mild ICI diarrhea and colitis among patients with delayed symptom onset with lower colonic inflammatory burden."8.31Mesalamine and cholestyramine for immune checkpoint inhibitor-mediated diarrhea and colitis. ( Alasadi, M; Altan, M; Hollander, B; Jacob, JS; Khurana, S; Thomas, AS; Varatharajalu, K; Wang, J; Wang, Y; Zhao, D, 2023)
"Mesalamine (MES), also known as 5-aminosalicylic acid, is effective in treating mild to moderate ulcerative colitis (UC)."8.12Mesalamine-Mediated Amelioration of Experimental Colitis in Piglets Involves Gut Microbiota Modulation and Intestinal Immune Cell Infiltration. ( Huang, Y; Liu, H; Wu, M; Xiao, H; Yang, G, 2022)
"For local treatment of ulcerative colitis, a new azoreductase driven prodrug CDDO-AZO from bardoxolone methyl (CDDO-Me) and 5-aminosalicylate (5-ASA) was designed, synthesized and biologically evaluated."8.02Identification of a new azoreductase driven prodrug from bardoxolone methyl and 5-aminosalicylate for the treatment of colitis in mice. ( Gong, Y; Huang, ZJ; Mou, Y; Qiao, X; Wen, XD; Zhang, YH, 2021)
"We examined whether metoclopramide (MCP), a modulator of dopamine and serotonin receptors, alleviated colitis and had synergistic effects when coadministered with 5-aminosalicylic acid (5-ASA) in an experimental model of colitis."7.91A colon-specific prodrug of metoclopramide ameliorates colitis in an experimental rat model. ( Jeong, S; Jung, Y; Kim, D; Kim, W; Yang, Y; Yoo, JW, 2019)
" The present study was conducted to make comparison on therapeutic effectiveness of rectally administered FO and mesalazine in rats with trinitrobenzenesulfonic acid (TNBS)-induced colitis."7.91Therapeutic effectiveness of rectally administered fish oil and mesalazine in trinitrobenzenesulfonic acid-induced colitis. ( Altınay, S; Çelik, DS; Gökmen, ES; Küçük, SH; Şit, D; Yorulmaz, E; Yorulmaz, H; Zengi, O, 2019)
"The present study developed novel zinc ion cross-linked alginate/N-succinyl-chitosan (NSC) blend microspheres (MS) for co-delivery of zinc and 5-aminosalicylic acid (5-ASA) for synergistic therapy of colitis."7.85Co-delivery of zinc and 5-aminosalicylic acid from alginate/N-succinyl-chitosan blend microspheres for synergistic therapy of colitis. ( Bai, X; Duan, H; Gao, C; Liu, M; Liu, Z; Lü, S; Qin, H; Wei, Y; Wu, X; Zhang, X, 2017)
"Mesalamine (5-ASA) is one of the drugs indicated as first line therapy in ulcerative colitis for induction and maintenance of remission."7.83Discovery and preclinical development of a novel prodrug conjugate of mesalamine with eicosapentaenoic acid and caprylic acid for the treatment of inflammatory bowel diseases. ( Kandula, M; Palanichamy, S; Rampal, A; Sunil Kumar, KB, 2016)
"Male mice imprinting control regions (ICR) were randomly divided into five groups: normal, TNBS-induced colitis, colitis treated with liquiritigenin at low dose (10 mg/kg) and high dose (20 mg/kg), or mesalazine (10 mg/kg)."7.81Amelioration of trinitrobenzene sulfonic acid-induced colitis in mice by liquiritigenin. ( Bae, H; Cha, JM; Jang, SE; Kim, DH; Kim, HJ; Lee, CH; Lim, SJ; Min, JK; Park, JW, 2015)
" in normal gut mucosa and mucosa of animals with TNBS colitis, as well as the influence of Mesalamine (M."7.80Effect of mesalamine and prednisolone on TNBS experimental colitis, following various doses of orally administered iron. ( Agrogiannis, G; Douvi, G; Gikas, A; Papalois, AE; Patsouris, E; Triantafillidis, JK, 2014)
" Here, we examined the effects of THSG on experimental mice with colitis induced by acetic acid and whether the underlying mechanisms were associated with the PPAR-γ and NF-κB pathways."7.77Beneficial effects of THSG on acetic acid-induced experimental colitis: involvement of upregulation of PPAR-γ and inhibition of the Nf-Κb inflammatory pathway. ( Chang, MJ; Wang, JL; Xiao, JH; Zeng, C, 2011)
" In order to elucidate the pesticide effect and the mechanisms by which paeoniflorin exerts its effect of anti-inflammation and immunoregulation on oxazolone-induced colitic mice, disease activity index (DAI) and histological grading of colitis (HGC) were evaluated in animal model."7.76[Paeoniflorin increases beta-defensin expression and attenuates lesion in the colonic mucosa from mice with oxazolone-induced colitis]. ( Li, YS; Tao, YW; Wang, H; Zhang, JY; Zhang, ZQ; Zhou, Y, 2010)
"The aim of the present studies was to examine mechanisms by which the rectally administered combination of N-acetylcysteine (NAC) plus mesalamine (5-ASA) affects inducers of inflammation to promote mucosal healing and reduce tissue inflammation in chemically (trinitrobenzene sulfonic acid, TNBS) induced colitis in rats."7.75Effects of N-acetylcysteine plus mesalamine on prostaglandin synthesis and nitric oxide generation in TNBS-induced colitis in rats. ( Ancha, HR; Harty, RF; Kurella, RR; Lightfoot, S; McKimmey, CC, 2009)
"To investigate the effect of balsalazide on intestinal mucosal permeability of experimental colitis induced by dextran sulfate sodium(DSS) in a mouse model and its possible mechanism."7.75[Effect of balsalazide on intestinal mucosal permeability of dextran sulfate sodium-induced colitis in mice]. ( Hu, J; Liu, XC; Mei, Q; Xu, JM, 2009)
"An experimental ulcerative colitis model was established by rectal injection of oxazolone into the colon of 40 Wistar rats randomly divided into four groups."7.75Therapeutic effects of Clostridium butyricum on experimental colitis induced by oxazolone in rats. ( Cui, YL; Ding, TT; Yang, X; Zhang, HQ; Zhang, HX; Zhang, JJ; Zhao, JS, 2009)
"Previously, we reported that oral administration of taurine conjugated 5-aminosalicylic acid, a colon-specific prodrug of 5-aminosalicylic acid (5-ASA), is effective in ameliorating experimental colitis and taurine elicits an additive anti-inflammatory effect upon cotreatment with 5-ASA."7.75An anti-inflammatory mechanism of taurine conjugated 5-aminosalicylic acid against experimental colitis: taurine chloramine potentiates inhibitory effect of 5-aminosalicylic acid on IL-1beta-mediated NFkappaB activation. ( Choi, D; Han, J; Hong, S; Joo, K; Jung, Y; Kim, YM; Lee, Y, 2009)
" The ameliorating effect of the azo conjugate and therapeutic efficacy of the carrier system was evaluated in trinitrobenzenesulfonic acid-induced experimental colitis model."7.74Colon-specific, mutual azo prodrug of 5-aminosalicylic acid with L-tryptophan: synthesis, kinetic studies and evaluation of its mitigating effect in trinitrobenzenesulfonic acid-induced colitis in rats. ( Bhatt, L; Dhaneshwar, SS; Gairola, N; Kandpal, M; Vadnerkar, G, 2007)
"Previous experiments in rats with chemically induced colitis have shown that the antioxidant N-acetylcysteine plus mesalamine (5-ASA) exerted a significantly greater therapeutic effect in promoting mucosal healing when compared to either agent alone."7.74Luminal antioxidants enhance the effects of mesalamine in the treatment of chemically induced colitis in rats. ( Ancha, HR; Harty, RF; Kurella, RR; Lightfoot, S; McKimmey, CC, 2008)
"We prospectively investigated colonoscopic biopsies from five groups of 20 subjects each: patients with ulcerative or indeterminate colitis treated with azathioprine (group 1), azathioprine and 5-ASA (group 2), 5-ASA (group 3), untreated IBD (group 4), and healthy controls."7.74Azathioprine and mesalazine-induced effects on the mucosal flora in patients with IBD colitis. ( Bengmark, S; Dörffel, Y; Lochs, H; Loening-Baucke, V; Swidsinski, A, 2007)
"Mesalamine is the first-line therapy for colitis, but it lacks potency and is only effective for mild-to-moderate forms of this disease."7.74Enhanced activity of a hydrogen sulphide-releasing derivative of mesalamine (ATB-429) in a mouse model of colitis. ( Caliendo, G; Cirino, G; Distrutti, E; Fiorucci, S; Mencarelli, A; Orlandi, S; Santagada, V; Santucci, L; Wallace, JL, 2007)
"The aims of this study were to examine the ability of the antioxidant N-acetylcysteine (NAC) and mesalamine (5-ASA) alone and in combination to affect TNBS-induced colitis in rat."7.73Antioxidant therapy with N-acetylcysteine plus mesalamine accelerates mucosal healing in a rodent model of colitis. ( Ancha, H; Harty, RF; Lightfoot, S; Siddiqui, A; Stewart, CA; Tedesco, D, 2006)
"Colitis was induced using the iodoacetamide rat model, and rats were divided into different dietary groups of 6 rats each: 1, normal chow diet (control); 2, diet supplemented with iron; 3, iron supplementation and lycopene; 4, iron and Beta-carotene; 5, 5-ASA; 6, 5-ASA and lycopene; 7, 5-ASA and iron; 8, 5-ASA, iron, and lycopene."7.725-ASA and lycopene decrease the oxidative stress and inflammation induced by iron in rats with colitis. ( Bujanover, Y; Matas, Z; Nissenkorn, A; Reifen, R, 2004)
" The purpose of the present study was to investigate the effects of mesalazine, and metronidazole-gentamicin combination, on bacterial translocation in an animal colitis model."7.72Effect of mesalazine, metronidazole and gentamicin on bacterial translocation in experimental colitis. ( Aydogan, H; Gulec, B; Kilinc, M; Kozak, O; Ozcan, A; Pekcan, M; Yigit, T; Yigitler, C, 2004)
"The anti-inflammatory effect of c-phycocyanin extract was studied in acetic acid-induced colitis in rats."7.70Anti-inflammatory activity of phycocyanin extract in acetic acid-induced colitis in rats. ( Ancheta, O; Armesto, J; González, A; González, R; Merino, N; Remirez, D; Rodríguez, S; Romay, C, 1999)
"The aim of this study was to investigate the role of 1-glutamine, short chain fatty acid, prednisolone, and mesalazine (5-aminosalicylic acid) enemas on mucosal damage and inflammation in experimental colitis."7.70L-glutamine enemas attenuate mucosal injury in experimental colitis. ( Bayer, A; Gür, ES; Kaya, E; Ozgüç, H; Tokyay, R, 1999)
"Ropivacaine, a new, long-acting local anesthetic agent, has been shown to have beneficial effects in the treatment of ulcerative colitis."7.70Beneficial effects of ropivacaine in rat experimental colitis. ( Hellström, PM; Ljung, T; Martinsson, T; Rubio, C, 1999)
"Rats with induced colitis were treated with sodium butyrate, mesalamine, sodium butyrate plus mesalamine, or saline enemas."7.69Butyrate, mesalamine, and factor XIII in experimental colitis in the rat: effects on transglutaminase activity. ( Cosenza, V; D'Argenio, G; D'Armiento, FP; De Ritis, F; Delle Cave, M; Gatto, A; Mazzacca, G; Sorrentini, I, 1994)
"The effect of intracolonic administration of zileuton (a 5-lipoxygenase inhibitor) on colonic damage and eicosanoid local release was assessed in a rat model of colitis."7.69Intracolonic administration of zileuton, a selective 5-lipoxygenase inhibitor, accelerates healing in a rat model of chronic colitis. ( Bartolí, R; Bertrán, X; Castellá, E; Esteve, M; Fernández-Bañares, F; Gassull, MA; Mañé, J; Ojanguren, I, 1996)
"The effect of epidermal growth factor on the rate of healing was examined in a rat model of colitis."7.68Effect of epidermal growth factor on experimental colitis in the rat. ( Bass, P; Luck, MS, 1993)
"The efficacy of the leukocyte recruitment inhibitor, N-[9H-2,7-dimethylfluoren-9-ylmethoxy)carbonyl]-L-leucine (NPC 15669) was compared with drugs used to treat inflammatory bowel diseases in a rat model, acetic acid-induced colitis."7.68NPC 15669, an inhibitor of neutrophil recruitment, is efficacious in acetic acid-induced colitis in rats. ( Burch, RM; Lowe, VC; Muhlhauser, RO; Noronha-Blob, L, 1993)
"Mesalamine was effective for treatment of chronic diarrhea and moderate nonspecific colitis in HIV patients."6.72Double-blind pilot study of mesalamine vs. placebo for treatment of chronic diarrhea and nonspecific colitis in immunocompetent HIV patients. ( Fernández-Carbia, A; Marxuach-Cuétara, AM; Ríos-Bedoya, CF; Rodríguez-Orengo, JF; Rodríguez-Torres, M; Salgado-Mercado, R, 2006)
"Colitis was induced in mice by intracolonic (i."5.51Evaluation of the effect of liposomes loaded with chlorogenic acid in treatment of 2,4,6-trinitrobenzenesulfonic acid-induced murine colitis. ( Chen, C; Czapor-Irzabek, H; Fichna, J; Gorniak, A; Karolewicz, B; Krajewska, JB; Owczarek, A; Pietruszka, P; Tomczyk, D, 2019)
"Colitis was induced in female swiss mice by adding DSS 3% to the drinking water."5.48Antioxidant and anti-inflammatory effect of plumieride in dextran sulfate sodium-induced colitis in mice. ( Andrade, SF; Boeing, T; Bonomini, TJ; da Silva, LM; de Souza, P; Lucinda, RM; Malheiros, A; Mariano, LNB; Somensi, LB, 2018)
"Colitis was induced by administration of 1 mL AA (4%) via a polyethylene catheter intrarectally."5.39Comparative protective effect of hawthorn berry hydroalcoholic extract, atorvastatin, and mesalamine on experimentally induced colitis in rats. ( Hobbenaghi, R; Malekinejad, H; Moshtaghion, SM; Shafie-Irannejad, V; Tabatabaie, SH, 2013)
"Colitis was induced by intrarectal administration of OXA solution (7."5.32Oxazolone-induced colitis in BALB/C mice: a new method to evaluate the efficacy of therapeutic agents for ulcerative colitis. ( Hatakeyama, S; Kojima, R; Kuroda, S; Nakamaru, K; Ohkishi, T, 2004)
"On day 1 colitis was induced with 50 mg TNBS/50% ethanol in female Sprague-Dawley rats, while controls received a saline enema."5.31Therapeutic role for bismuth compounds in TNBS-induced colitis in the rat. ( Cleary, CE; Malatjalian, DA; Peterson, TC; Shaw, AM; Veldhuyzen van Zanten, SJ, 2000)
"A pharmacokinetic model of colon-specific drug delivery developed in a previous study has been validated by use of 5-aminosalicylic acid (5-ASA) as a model anti-inflammatory drug."5.30Validation of a pharmacokinetic model of colon-specific drug delivery and the therapeutic effects of chitosan capsules containing 5-aminosalicylic acid on 2,4,6-trinitrobenzenesulphonic acid-induced colitis in rats. ( Fujita, T; Muranishi, S; Odoriba, T; Okabe, S; Terabe, A; Tozaki, H; Yamamoto, A, 1999)
"Pericarditis should be considered in any patient complaining of chest pain and/or dyspnea who is taking a product that contains mesalamine or sulfasalazine."4.81Possible mesalamine-induced pericarditis: case report and literature review. ( Malinowski, JM; Waite, RA, 2002)
"Mesalamine and/or cholestyramine may be effective for mild ICI diarrhea and colitis among patients with delayed symptom onset with lower colonic inflammatory burden."4.31Mesalamine and cholestyramine for immune checkpoint inhibitor-mediated diarrhea and colitis. ( Alasadi, M; Altan, M; Hollander, B; Jacob, JS; Khurana, S; Thomas, AS; Varatharajalu, K; Wang, J; Wang, Y; Zhao, D, 2023)
"Mesalamine (MES), also known as 5-aminosalicylic acid, is effective in treating mild to moderate ulcerative colitis (UC)."4.12Mesalamine-Mediated Amelioration of Experimental Colitis in Piglets Involves Gut Microbiota Modulation and Intestinal Immune Cell Infiltration. ( Huang, Y; Liu, H; Wu, M; Xiao, H; Yang, G, 2022)
"For local treatment of ulcerative colitis, a new azoreductase driven prodrug CDDO-AZO from bardoxolone methyl (CDDO-Me) and 5-aminosalicylate (5-ASA) was designed, synthesized and biologically evaluated."4.02Identification of a new azoreductase driven prodrug from bardoxolone methyl and 5-aminosalicylate for the treatment of colitis in mice. ( Gong, Y; Huang, ZJ; Mou, Y; Qiao, X; Wen, XD; Zhang, YH, 2021)
" The agents tested were: alpha-lactoalbumin (ALAC), a whey protein rich in tryptophan, effective in some animal models of epilepsy and on colon/intestine inflammation, valproic acid (VPA), an effective antiepileptic drug in this seizure model, mesalazine (MSZ) an effective aminosalicylate anti-inflammatory treatment against ulcerative colitis and sodium butyrate (NaB), a short chain fatty acid (SCFA) normally produced in the intestine by gut microbiota, important in maintaining gut health and reducing gut inflammation and oxidative stress."3.91Intestinal inflammation increases convulsant activity and reduces antiepileptic drug efficacy in a mouse model of epilepsy. ( Avagliano, C; Calignano, A; Citraro, R; Constanti, A; De Caro, C; De Sarro, G; di Cesare Mannelli, L; Ghelardini, C; Leo, A; Mainardi, P; Nesci, V; Russo, E; Striano, P, 2019)
"We examined whether metoclopramide (MCP), a modulator of dopamine and serotonin receptors, alleviated colitis and had synergistic effects when coadministered with 5-aminosalicylic acid (5-ASA) in an experimental model of colitis."3.91A colon-specific prodrug of metoclopramide ameliorates colitis in an experimental rat model. ( Jeong, S; Jung, Y; Kim, D; Kim, W; Yang, Y; Yoo, JW, 2019)
" The present study was conducted to make comparison on therapeutic effectiveness of rectally administered FO and mesalazine in rats with trinitrobenzenesulfonic acid (TNBS)-induced colitis."3.91Therapeutic effectiveness of rectally administered fish oil and mesalazine in trinitrobenzenesulfonic acid-induced colitis. ( Altınay, S; Çelik, DS; Gökmen, ES; Küçük, SH; Şit, D; Yorulmaz, E; Yorulmaz, H; Zengi, O, 2019)
" Our aim was to examine local and remote consequences of ASA-Tris administration in 2-,4-,6-trinitrobenzene-sulfonic acid (TNBS)-induced colitis as compared to ASA or mesalamine (5-aminosalicylate) treatment."3.88Acetylsalicylic acid-tris-hydroxymethyl-aminomethane reduces colon mucosal damage without causing gastric side effects in a rat model of colitis. ( Boros, M; Érces, D; Ghyczy, M; Hartmann, P; Jász, DK; Lajkó, N; Molnár, R; Szűcs, S; Tóth, G; Ugocsai, M; Varga, G, 2018)
" The strong inhibitory activity of compound 55 against an in vivo colitis model was confirmed by its dose-dependent inhibitory activity in a rat model of 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis, demonstrating compound 55 as a new potential candidate for the development of therapeutics against IBD."3.85Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease. ( Banskota, S; Bist, G; Gurung, P; Kadayat, TM; Kim, JA; Lee, ES; Shrestha, A; Thapa Magar, TB, 2017)
"), with that of 5-aminosalicylic acid (5-ASA), a first-line drug in IBD, in a 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis rat model."3.85Comparison of anti-inflammatory activities of an anthocyanin-rich fraction from Portuguese blueberries (Vaccinium corymbosum L.) and 5-aminosalicylic acid in a TNBS-induced colitis rat model. ( Almeida, LM; Dinis, TC; Figueiredo, I; Freitas, V; Pereira, R; Pereira, SR, 2017)
"The present study developed novel zinc ion cross-linked alginate/N-succinyl-chitosan (NSC) blend microspheres (MS) for co-delivery of zinc and 5-aminosalicylic acid (5-ASA) for synergistic therapy of colitis."3.85Co-delivery of zinc and 5-aminosalicylic acid from alginate/N-succinyl-chitosan blend microspheres for synergistic therapy of colitis. ( Bai, X; Duan, H; Gao, C; Liu, M; Liu, Z; Lü, S; Qin, H; Wei, Y; Wu, X; Zhang, X, 2017)
"This study represents the first evidence that combination therapy with balsalazide and parthenolide could be a new regimen for colorectal cancer treatment."3.85Combined Parthenolide and Balsalazide Have Enhanced Antitumor Efficacy Through Blockade of NF-κB Activation. ( Jeong, HJ; Kim, EM; Kim, IH; Kim, SH; Kim, SL; Kim, SW; Kim, YN; Lee, SO; Lee, ST; Liu, YC; Park, YR; Seo, SY, 2017)
" Oral gavage of 5-ASA-azo-PA alleviated 2,4,6-trinitrobenzenesulfonic acid-induced rat colitis."3.835-Aminosalicylic Acid Azo-Linked to Procainamide Acts as an Anticolitic Mutual Prodrug via Additive Inhibition of Nuclear Factor kappaB. ( Jeong, S; Jung, Y; Kim, W; Lee, S; Nam, J, 2016)
"In this work, thiolated chitosan/alginate composite microparticulates (CMPs) coated by Eudragit S-100 were developed for colon-specific delivery of 5-aminosalicylic acid (5-ASA) and curcumin (CUR), and the use of it as a multi drug delivery system for the treatment of colitis."3.83Mucoadhesive microparticulates based on polysaccharide for target dual drug delivery of 5-aminosalicylic acid and curcumin to inflamed colon. ( Bai, X; Duan, H; Gao, C; Liu, M; Lü, S; Qin, H; Wei, Y; Wu, X, 2016)
"Mesalamine (5-ASA) is one of the drugs indicated as first line therapy in ulcerative colitis for induction and maintenance of remission."3.83Discovery and preclinical development of a novel prodrug conjugate of mesalamine with eicosapentaenoic acid and caprylic acid for the treatment of inflammatory bowel diseases. ( Kandula, M; Palanichamy, S; Rampal, A; Sunil Kumar, KB, 2016)
"Male mice imprinting control regions (ICR) were randomly divided into five groups: normal, TNBS-induced colitis, colitis treated with liquiritigenin at low dose (10 mg/kg) and high dose (20 mg/kg), or mesalazine (10 mg/kg)."3.81Amelioration of trinitrobenzene sulfonic acid-induced colitis in mice by liquiritigenin. ( Bae, H; Cha, JM; Jang, SE; Kim, DH; Kim, HJ; Lee, CH; Lim, SJ; Min, JK; Park, JW, 2015)
" Colonic specificity of 5-ASA tablets (prepared using guar gum and pectin as polymers) was evaluated in vitro using simulated fluids mimicking in vivo environment as well as in vivo method using chemically (2,4,6-trinitrobenzenesulfonic acid and acetic acid)-induced colitis rat model."3.81In Vivo Evaluation of 5-ASA Colon-Specific Tablets Using Experimental-Induced Colitis Rat Animal Model. ( Bajaj, AN; Deshpande, SG; Nikam, VS; Sawarkar, SP, 2015)
"To investigate the therapeutic and immunoregulatory effects of 1,25-dihydroxyvitamin D (1,25(OH)D3) on 2,4,6-trinitrobenzenesulfonic acid (TNBS) -induced colitis in rats."3.811,25-hydroxyvitamin D relieves colitis in rats via down-regulation of toll-like receptor 9 expression. ( Dai, ZH; Lv, H; Qian, JM; Tan, B; Wang, O; Yang, H, 2015)
" in normal gut mucosa and mucosa of animals with TNBS colitis, as well as the influence of Mesalamine (M."3.80Effect of mesalamine and prednisolone on TNBS experimental colitis, following various doses of orally administered iron. ( Agrogiannis, G; Douvi, G; Gikas, A; Papalois, AE; Patsouris, E; Triantafillidis, JK, 2014)
" The effects of RNP(O) were determined in mice with dextran sodium sulfate (DSS)-induced colitis and compared with those of low-molecular-weight drugs (4-hydroxyl-2,2,6,6-tetramethylpiperidine-1-oxyl [TEMPOL] or mesalamine)."3.78An orally administered redox nanoparticle that accumulates in the colonic mucosa and reduces colitis in mice. ( Matsui, H; Nagasaki, Y; Tomita, T; Vong, LB; Yoshitomi, T, 2012)
" Subsequently, its protective effect in indomethacin and iodoacetamide induced colitis in rats (45, 90, 180, 270 mg/kg) and acetic acid induced colitis in mice (65, 130, 250, 500 mg/kg) was assessed."3.77Protective effect of aqueous extract of Bombax malabaricum DC on experimental models of inflammatory bowel disease in rats and mice. ( Jagtap, AG; Niphadkar, PV; Phadke, AS, 2011)
" Here, we examined the effects of THSG on experimental mice with colitis induced by acetic acid and whether the underlying mechanisms were associated with the PPAR-γ and NF-κB pathways."3.77Beneficial effects of THSG on acetic acid-induced experimental colitis: involvement of upregulation of PPAR-γ and inhibition of the Nf-Κb inflammatory pathway. ( Chang, MJ; Wang, JL; Xiao, JH; Zeng, C, 2011)
" The in vivo antineoplastic effect of 2-methoxy-5-amino-N-hydroxybenzamide (2-14) was evaluated in a syngenic, CT26-derived xenograft mouse model of CRC and in the azoxymethane/dextran sulfate sodium-induced mouse model of colitis-associated CRC."3.76Inhibition of colon carcinogenesis by 2-methoxy-5-amino-N-hydroxybenzamide, a novel derivative of mesalamine. ( Caruso, R; Fantini, MC; Fina, D; Macdonald, TT; Monteleone, G; Pallone, F; Palmieri, G; Pellegrini, R; Sarra, M; Stolfi, C, 2010)
" In order to elucidate the pesticide effect and the mechanisms by which paeoniflorin exerts its effect of anti-inflammation and immunoregulation on oxazolone-induced colitic mice, disease activity index (DAI) and histological grading of colitis (HGC) were evaluated in animal model."3.76[Paeoniflorin increases beta-defensin expression and attenuates lesion in the colonic mucosa from mice with oxazolone-induced colitis]. ( Li, YS; Tao, YW; Wang, H; Zhang, JY; Zhang, ZQ; Zhou, Y, 2010)
" The prodrugs exhibited comparable ameliorating effect as that of sulfasalazine on trinitrobenzenesulfonic acid-induced experimental colitis in rats with a better safety profile."3.75Synthesis, kinetic studies and pharmacological evaluation of mutual azo prodrugs of 5-aminosalicylic acid for colon-specific drug delivery in inflammatory bowel disease. ( Bhatt, L; Dhaneshwar, SS; Gairola, N; Kadam, SS; Kandpal, M; Rathi, B; Vadnerkar, G, 2009)
"The aim of the present studies was to examine mechanisms by which the rectally administered combination of N-acetylcysteine (NAC) plus mesalamine (5-ASA) affects inducers of inflammation to promote mucosal healing and reduce tissue inflammation in chemically (trinitrobenzene sulfonic acid, TNBS) induced colitis in rats."3.75Effects of N-acetylcysteine plus mesalamine on prostaglandin synthesis and nitric oxide generation in TNBS-induced colitis in rats. ( Ancha, HR; Harty, RF; Kurella, RR; Lightfoot, S; McKimmey, CC, 2009)
"To investigate the effect of balsalazide on intestinal mucosal permeability of experimental colitis induced by dextran sulfate sodium(DSS) in a mouse model and its possible mechanism."3.75[Effect of balsalazide on intestinal mucosal permeability of dextran sulfate sodium-induced colitis in mice]. ( Hu, J; Liu, XC; Mei, Q; Xu, JM, 2009)
"An experimental ulcerative colitis model was established by rectal injection of oxazolone into the colon of 40 Wistar rats randomly divided into four groups."3.75Therapeutic effects of Clostridium butyricum on experimental colitis induced by oxazolone in rats. ( Cui, YL; Ding, TT; Yang, X; Zhang, HQ; Zhang, HX; Zhang, JJ; Zhao, JS, 2009)
"Previously, we reported that oral administration of taurine conjugated 5-aminosalicylic acid, a colon-specific prodrug of 5-aminosalicylic acid (5-ASA), is effective in ameliorating experimental colitis and taurine elicits an additive anti-inflammatory effect upon cotreatment with 5-ASA."3.75An anti-inflammatory mechanism of taurine conjugated 5-aminosalicylic acid against experimental colitis: taurine chloramine potentiates inhibitory effect of 5-aminosalicylic acid on IL-1beta-mediated NFkappaB activation. ( Choi, D; Han, J; Hong, S; Joo, K; Jung, Y; Kim, YM; Lee, Y, 2009)
" The ameliorating effect of the azo conjugate and therapeutic efficacy of the carrier system was evaluated in trinitrobenzenesulfonic acid-induced experimental colitis model."3.74Colon-specific, mutual azo prodrug of 5-aminosalicylic acid with L-tryptophan: synthesis, kinetic studies and evaluation of its mitigating effect in trinitrobenzenesulfonic acid-induced colitis in rats. ( Bhatt, L; Dhaneshwar, SS; Gairola, N; Kandpal, M; Vadnerkar, G, 2007)
"Previous experiments in rats with chemically induced colitis have shown that the antioxidant N-acetylcysteine plus mesalamine (5-ASA) exerted a significantly greater therapeutic effect in promoting mucosal healing when compared to either agent alone."3.74Luminal antioxidants enhance the effects of mesalamine in the treatment of chemically induced colitis in rats. ( Ancha, HR; Harty, RF; Kurella, RR; Lightfoot, S; McKimmey, CC, 2008)
"We prospectively investigated colonoscopic biopsies from five groups of 20 subjects each: patients with ulcerative or indeterminate colitis treated with azathioprine (group 1), azathioprine and 5-ASA (group 2), 5-ASA (group 3), untreated IBD (group 4), and healthy controls."3.74Azathioprine and mesalazine-induced effects on the mucosal flora in patients with IBD colitis. ( Bengmark, S; Dörffel, Y; Lochs, H; Loening-Baucke, V; Swidsinski, A, 2007)
"Mesalamine is the first-line therapy for colitis, but it lacks potency and is only effective for mild-to-moderate forms of this disease."3.74Enhanced activity of a hydrogen sulphide-releasing derivative of mesalamine (ATB-429) in a mouse model of colitis. ( Caliendo, G; Cirino, G; Distrutti, E; Fiorucci, S; Mencarelli, A; Orlandi, S; Santagada, V; Santucci, L; Wallace, JL, 2007)
" In this study, we examined the effects of 2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside (THSG), an active component extracted from Polygonum multiflorum Thunb, on acetic acid-induced acute colitis and mitomycin C-induced chronic colitis."3.74Protective effects of 2,3,5,4'-tetrahydroxystilbene-2-O-beta-d-glucoside, an active component of Polygonum multiflorum Thunb, on experimental colitis in mice. ( Chen, S; Han, T; Wang, J; Wang, X; Zhao, L, 2008)
"The aims of this study were to examine the ability of the antioxidant N-acetylcysteine (NAC) and mesalamine (5-ASA) alone and in combination to affect TNBS-induced colitis in rat."3.73Antioxidant therapy with N-acetylcysteine plus mesalamine accelerates mucosal healing in a rodent model of colitis. ( Ancha, H; Harty, RF; Lightfoot, S; Siddiqui, A; Stewart, CA; Tedesco, D, 2006)
"Colitis was induced using the iodoacetamide rat model, and rats were divided into different dietary groups of 6 rats each: 1, normal chow diet (control); 2, diet supplemented with iron; 3, iron supplementation and lycopene; 4, iron and Beta-carotene; 5, 5-ASA; 6, 5-ASA and lycopene; 7, 5-ASA and iron; 8, 5-ASA, iron, and lycopene."3.725-ASA and lycopene decrease the oxidative stress and inflammation induced by iron in rats with colitis. ( Bujanover, Y; Matas, Z; Nissenkorn, A; Reifen, R, 2004)
" The purpose of the present study was to investigate the effects of mesalazine, and metronidazole-gentamicin combination, on bacterial translocation in an animal colitis model."3.72Effect of mesalazine, metronidazole and gentamicin on bacterial translocation in experimental colitis. ( Aydogan, H; Gulec, B; Kilinc, M; Kozak, O; Ozcan, A; Pekcan, M; Yigit, T; Yigitler, C, 2004)
"The anti-inflammatory effect of c-phycocyanin extract was studied in acetic acid-induced colitis in rats."3.70Anti-inflammatory activity of phycocyanin extract in acetic acid-induced colitis in rats. ( Ancheta, O; Armesto, J; González, A; González, R; Merino, N; Remirez, D; Rodríguez, S; Romay, C, 1999)
"Effects of an NO-releasing derivative of mesalamine (NCX-456; NO-mesalamine) were compared with those of mesalamine itself and 2 other NO donors in a rat model of colitis."3.70Enhanced anti-inflammatory effects of a nitric oxide-releasing derivative of mesalamine in rats. ( Asfaha, S; Chapman, K; Del Soldato, P; Fiorucci, S; McKnight, W; Morelli, A; Muscará, MN; Vergnolle, N; Wallace, JL, 1999)
"The aim of this study was to investigate the role of 1-glutamine, short chain fatty acid, prednisolone, and mesalazine (5-aminosalicylic acid) enemas on mucosal damage and inflammation in experimental colitis."3.70L-glutamine enemas attenuate mucosal injury in experimental colitis. ( Bayer, A; Gür, ES; Kaya, E; Ozgüç, H; Tokyay, R, 1999)
"Ropivacaine, a new, long-acting local anesthetic agent, has been shown to have beneficial effects in the treatment of ulcerative colitis."3.70Beneficial effects of ropivacaine in rat experimental colitis. ( Hellström, PM; Ljung, T; Martinsson, T; Rubio, C, 1999)
"Rats with induced colitis were treated with sodium butyrate, mesalamine, sodium butyrate plus mesalamine, or saline enemas."3.69Butyrate, mesalamine, and factor XIII in experimental colitis in the rat: effects on transglutaminase activity. ( Cosenza, V; D'Argenio, G; D'Armiento, FP; De Ritis, F; Delle Cave, M; Gatto, A; Mazzacca, G; Sorrentini, I, 1994)
"Amplified chemiluminescence was used to measure reactive oxygen species production by colonic biopsy specimens from rats with acetic acid induced colitis and to assess the in vitro effect of conventional antioxidants, standard therapies and proposed novel therapies for inflammatory bowel disease."3.69Evaluating the antioxidant potential of new treatments for inflammatory bowel disease using a rat model of colitis. ( Blades, S; Blake, DR; Chander, CL; Claxson, AW; Coumbe, A; Millar, AD; Morris, CJ; Panetta, J; Rampton, DS, 1996)
"The effect of intracolonic administration of zileuton (a 5-lipoxygenase inhibitor) on colonic damage and eicosanoid local release was assessed in a rat model of colitis."3.69Intracolonic administration of zileuton, a selective 5-lipoxygenase inhibitor, accelerates healing in a rat model of chronic colitis. ( Bartolí, R; Bertrán, X; Castellá, E; Esteve, M; Fernández-Bañares, F; Gassull, MA; Mañé, J; Ojanguren, I, 1996)
"A rat model of colitis [dextran sulfate (DSS)] was used to study the permeation of Evans blue (EB) from the lumen into the wall of proximal and distal colonic loops after exposure to the dye for 2 hr."3.69Influence of topical rectal application of drugs on dextran sulfate-induced colitis in rats. ( Ahlman, H; Björck, S; Dahlström, A; Jennische, E, 1997)
"The effect of epidermal growth factor on the rate of healing was examined in a rat model of colitis."3.68Effect of epidermal growth factor on experimental colitis in the rat. ( Bass, P; Luck, MS, 1993)
"The efficacy of the leukocyte recruitment inhibitor, N-[9H-2,7-dimethylfluoren-9-ylmethoxy)carbonyl]-L-leucine (NPC 15669) was compared with drugs used to treat inflammatory bowel diseases in a rat model, acetic acid-induced colitis."3.68NPC 15669, an inhibitor of neutrophil recruitment, is efficacious in acetic acid-induced colitis in rats. ( Burch, RM; Lowe, VC; Muhlhauser, RO; Noronha-Blob, L, 1993)
"Mesalamine was effective for treatment of chronic diarrhea and moderate nonspecific colitis in HIV patients."2.72Double-blind pilot study of mesalamine vs. placebo for treatment of chronic diarrhea and nonspecific colitis in immunocompetent HIV patients. ( Fernández-Carbia, A; Marxuach-Cuétara, AM; Ríos-Bedoya, CF; Rodríguez-Orengo, JF; Rodríguez-Torres, M; Salgado-Mercado, R, 2006)
"In patients with Crohn's colitis or ileocolitis, or in those with ileitis, no statistically significant differences were noted with respect to the relapse rates between the 5-ASA and the placebo treatment groups."2.68Mesalazine (Mesasal/Claversal) 1.5 g b.d. vs. placebo in the maintenance of remission of patients with Crohn's disease. ( Adler, M; Bailey, RJ; Rachmilewitz, D; Thomson, AB; Vatn, M; Wilson-Lynch, KA; Wright, JP, 1995)
"Microscopic colitis is a recently recognized cause of diarrhoea, predominantly affecting older women, but its response to treatment is poorly documented."2.67Response to treatment of microscopic colitis. ( Fasoli, R; Jewell, DP, 1994)
"The genetics of isolated colonic Crohn's disease place it approximately midway between Crohn's disease with small intestinal involvement and UC, making a case for considering it as a separate condition."2.55Recent advances in clinical practice: a systematic review of isolated colonic Crohn's disease: the third IBD? ( Ekbom, A; Rhodes, JM; Subramanian, S, 2017)
"Individuals with ulcerative colitis face an increased risk of developing colorectal cancer and would benefit from early chemopreventive intervention."2.49Differential response of flat and polypoid colitis-associated colorectal neoplasias to chemopreventive agents and heterocyclic amines. ( Chang, WC; Clapper, ML; Cooper, HS; Zenser, TV, 2013)
"Segmental colitis associated with colonic diverticulosis is a new and emerging entity."2.48Segmental colitis associated with diverticulosis: systematic evaluation of 486 cases with meta-analysis. ( Hoda, KK; Mann, NS, 2012)
"Conventional therapies for ulcerative colitis and Crohn's disease (CD) include aminosalicylates, corticosteroids, thiopurines, methotrexate, and anti-tumor necrosis factor agents."2.47Conventional medical management of inflammatory bowel disease. ( Burger, D; Travis, S, 2011)
"Eosinophilic colitis is an idiopathic inflammation of the alimentary canal and is characterized by infiltration of the intestinal wall by eosinophils, massive submucosal edema, and peripheral eosinophilia."2.47Eosinophilic-Crohn overlap colitis and review of the literature. ( Katsanos, KH; Lambri, E; Tsianos, EV; Zinovieva, E, 2011)
"In familial and sporadic colorectal cancer, aspirin, other nonsteroidal anti-inflammatory drugs and cyclo-oxygenase-2 inhibitors have been tested for their ability to reduce polyp and cancer development in clinical studies."2.42Review article: the chemoprevention of colorectal carcinoma. ( Gasche, C, 2004)
"Whereas the incidence of ulcerative colitis has remained stable at around 8-9/10(5), the incidence of Crohn's disease has increased from below 1 to more than 5/10(5) per year during the last three decades."2.41[Therapeutic principles for chronic inflammatory bowel disease]. ( Binder, V; Munkholm, P, 2001)
"Mesalazine is an aminosalicillic derivative considered as a safe alternative to the relative frequency (5-55%) of adverse effects observed with sulfasalazine."2.40[Non-immunoallergic hepatotoxicity due to mesalazine]. ( Barroso, N; Gavilán, F; Guil, A; Larrauri, J; Leo, E; Reina, FR; Tirado, C; Zafra, C, 1999)
"Because intestinal inflammation affects the gut microbiota and 5-ASA can change the severity of inflammation, assessing the impact of inflammation and 5-ASA on the gut microbiota is not feasible in a clinical study of patients with UC."1.915-Aminosalicylic acid alters the gut microbiota and altered microbiota transmitted vertically to offspring have protective effects against colitis. ( Akimoto, Y; Hibi, N; Hibi, T; Hisamatsu, T; Kobayashi, T; Kuronuma, S; Lee, STM; Matsuura, M; Miyoshi, J; Nishinarita, Y; Oguri, N; Takeuchi, O; Wada, H, 2023)
"Ulcerative colitis is a relapsing and remitting disease that may be associated with flares."1.91Factors contributing to flares of ulcerative colitis in North India- a case-control study. ( Dutta, U; Jearth, V; Mahajan, G; Patil, AN; Rana, VS; Saroch, A; Sekar, A; Sharma, V; Singh, AK; Singh, H, 2023)
"Phycocyanobilin was obtained by solvothermal alcoholysis of phycocyanin and characterized by spectroscopy and mass spectrometry methods."1.72Phycocyanin ameliorates mouse colitis ( Guo, W; Li, S; Qian, Y; Wu, H; Zeng, M; Zhu, S, 2022)
"However, the PPS-treated colitis group showed higher gene expression of IL-35 EBI3 subunit by 1."1.72Pentosan Polysulfate Sodium augments the therapeutic effect of 5-Aminosalicylic Acid in DSS colitis model; the role of IL-35 expression. ( AbdElfattah, AA; Ashour, RH; El-Kady, RA; Elmasry, A; Hazem, NM, 2022)
"Diversion colitis and ulcerative colitis (UC) can be caused by different mechanisms; however, several case reports have described the development of typical UC following diversion colitis."1.72Progression of ulcerative colitis following diversion colitis. ( Araki, K; Inayama, Y; Kimura, H; Kumagai, J; Kunisaki, R; Maeda, S; Matsune, Y; Yaguchi, K, 2022)
"Infliximab is used for ulcerative colitis but could also be effective against severe DC."1.62Novel application of infliximab for diversion colitis. ( Kido, M; Okajima, H; Tamura, R; Yasui, Y, 2021)
"Colitis was induced in mice using 2,4,6-trinitrobenzene-sulfonic acid (TNBS), and mice were subsequently treated with either a PD-1 inhibitor or 5-amino-salicylic acid (ASA) as a positive control."1.62Inhibition of PD-1 Protects against TNBS-Induced Colitis via Alteration of Enteric Microbiota. ( Du, YL; He, J; Huang, HL; Li, YF; Nie, YQ; Xu, HM; Xu, J; Zhao, C; Zhou, YJ; Zhou, YL, 2021)
"Colitis was induced in mice by intracolonic (i."1.51Evaluation of the effect of liposomes loaded with chlorogenic acid in treatment of 2,4,6-trinitrobenzenesulfonic acid-induced murine colitis. ( Chen, C; Czapor-Irzabek, H; Fichna, J; Gorniak, A; Karolewicz, B; Krajewska, JB; Owczarek, A; Pietruszka, P; Tomczyk, D, 2019)
"Colitis was diagnosed by histological analysis and the inflammatory reaction by validated score."1.51Enemas with mesalazine increase the tissue contents of mucins in the colonic mucosa devoid of fecal stream. ( Campos, FG; Goto, EFK; Kanno, DT; Martinez, CAR; Matijascic, GM; Meneses, EC; Pereira, JA, 2019)
"Colitis was induced in female swiss mice by adding DSS 3% to the drinking water."1.48Antioxidant and anti-inflammatory effect of plumieride in dextran sulfate sodium-induced colitis in mice. ( Andrade, SF; Boeing, T; Bonomini, TJ; da Silva, LM; de Souza, P; Lucinda, RM; Malheiros, A; Mariano, LNB; Somensi, LB, 2018)
"At day 3 after the beginning of the treatment, colitis was induced by intrarectal administration of trinitrobenzene sulfonic acid (TNBS)."1.42In vivo efficacy of microbiota-sensitive coatings for colon targeting: a promising tool for IBD therapy. ( Beghyn, T; Deprez, B; Desreumaux, P; Dubreuil, L; Dubuquoy, L; Flament, MP; Guerin-Deremaux, L; Karrout, Y; Moussa, E; Neut, C; Piveteau, C; Siepmann, F; Siepmann, J; Wils, D, 2015)
"As seen in active ulcerative colitis (UC), the formation of crypt abscesses was observed in the biopsy."1.42A case of diverticular colitis with lesions resembling ulcerative colitis and correlation of tumor necrosis factor-alpha staining with clinical manifestations. ( Inui, K; Katano, Y; Kobayashi, T; Kosaka, T; Torii, Y; Wakabayasi, T; Yoshino, J, 2015)
"Eosinophilic colitis is a rare mostly self-limiting disease affecting middle-aged adults."1.40Eosinophilic colitis is a sporadic self-limited disease of middle-aged people: a population-based study. ( Alfadda, AA; Shaffer, EA; Storr, MA; Urbanski, SJ, 2014)
"Colitis was induced by administration of 1 mL AA (4%) via a polyethylene catheter intrarectally."1.39Comparative protective effect of hawthorn berry hydroalcoholic extract, atorvastatin, and mesalamine on experimentally induced colitis in rats. ( Hobbenaghi, R; Malekinejad, H; Moshtaghion, SM; Shafie-Irannejad, V; Tabatabaie, SH, 2013)
"Colitis was induced by intrarectal injection of TNBS while control rats received the vehicle."1.39Adjunct therapy of n-3 fatty acids to 5-ASA ameliorates inflammatory score and decreases NF-κB in rats with TNBS-induced colitis. ( Aziz, M; Bole-Feysot, C; Charpentier, C; Déchelotte, P; Guérin, C; Marion-Letellier, R; Mbodji, K; Querec, C; Savoye, G, 2013)
"Colitis was evaluated by means of the length of the colon, white blood cell count (WBC), tissue myeloperoxidase (MPO) activity, and histological inflammation scores."1.35Oral administration of mesalazine protects against mucosal injury and permeation in dextran sulfate sodium-induced colitis in rats. ( Aoyagi, K; Hayashi, Y; Morita, I; Sakisaka, S; Yamamoto, C, 2009)
"The risk of colorectal cancer is increased in patients with inflammatory bowel diseases, especially those with ulcerative colitis (UC)."1.345-aminosalicylic acid given in the remission stage of colitis suppresses colitis-associated cancer in a mouse colitis model. ( Endo, H; Fujisawa, T; Fujita, K; Ikeda, I; Inamori, M; Kubota, K; Nagashima, Y; Nakagama, H; Nakajima, A; Nozaki, Y; Saito, S; Takahashi, H; Tomimoto, A; Wada, K; Yoneda, M; Yonemitsu, K, 2007)
"Distal colitis was induced in male Wistar rats by colonic administration of TNBS and colonically treated with NaB, 5-ASA, combination of NaB and 5-ASA, and normal saline for 14 consecutive days."1.33Effects of topical treatment of sodium butyrate and 5-aminosalicylic acid on expression of trefoil factor 3, interleukin 1beta, and nuclear factor kappaB in trinitrobenzene sulphonic acid induced colitis in rats. ( Li, J; Song, M; Xia, B, 2006)
"Colitis was induced by intrarectal administration of OXA solution (7."1.32Oxazolone-induced colitis in BALB/C mice: a new method to evaluate the efficacy of therapeutic agents for ulcerative colitis. ( Hatakeyama, S; Kojima, R; Kuroda, S; Nakamaru, K; Ohkishi, T, 2004)
"On day 1 colitis was induced with 50 mg TNBS/50% ethanol in female Sprague-Dawley rats, while controls received a saline enema."1.31Therapeutic role for bismuth compounds in TNBS-induced colitis in the rat. ( Cleary, CE; Malatjalian, DA; Peterson, TC; Shaw, AM; Veldhuyzen van Zanten, SJ, 2000)
"Relapse was defined by CD Activity Index > or = 150, CD Endoscopic Index of Severity > or =4, and by an abnormal increase of C-reactive protein, white blood cell count, and erythrocyte sedimentation rate; moreover, if it was confirmed by x-ray and/or endoscopy."1.31Does the initial location of Crohn's disease have an influence on the time-to-relapse in patients under maintenance treatment with oral mesalamine? ( Bertoni, M; Bresci, G; Capria, A; Masolino, P; Parisi, G; Scatena, F, 2000)
"To investigate the possibility of local treatment of colitis with the adhesive antioxidant enzymes catalase and superoxide dismutase (SOD)."1.31The effect of local attachment of cationized antioxidant enzymes on experimental colitis in the rat. ( Bass, P; Blau, S; Kohen, R; Rubinstein, A, 2000)
"Collagenous colitis is a treatable condition in most patients."1.31Treatment responses in collagenous colitis. ( Fiedler, LM; George, J; Harpaz, N; Janowitz, HD; Kornbluth, AA; Sachar, DB, 2001)
"Diversion colitis is thought to result from nutritional deficiencies secondary to fecal diversion."1.30Diversion colitis: a cause of abdominal discomfort in spinal cord injury patients with colostomy. ( Chuang, TY; Francisco, GE; Lai, JM; Strayer, JR, 1997)
"Will pregnancy affect the disease? 4."1.30[Crohn's disease and pregnancy. A case report]. ( Gudiño Molina, FJ; Jinich Brook, H; Montiel-Jarquin, A; Rodríguez Torres, LF, 1998)
"A pharmacokinetic model of colon-specific drug delivery developed in a previous study has been validated by use of 5-aminosalicylic acid (5-ASA) as a model anti-inflammatory drug."1.30Validation of a pharmacokinetic model of colon-specific drug delivery and the therapeutic effects of chitosan capsules containing 5-aminosalicylic acid on 2,4,6-trinitrobenzenesulphonic acid-induced colitis in rats. ( Fujita, T; Muranishi, S; Odoriba, T; Okabe, S; Terabe, A; Tozaki, H; Yamamoto, A, 1999)
"In Crohn's disease as well as in ulcerative colitis steroids are of major importance in the treatment of active disease."1.29[Current therapeutic possibilities in chronic inflammatory intestinal diseases]. ( Schölmerich, J, 1995)
"A patient with chronic Reiter's syndrome (RS) refractory to nonsteroidal antiinflammatory therapy was prescribed mesalamine (Pentasa) therapy for a 4-month trial."1.29Mesalamine therapy in Reiter's syndrome. ( Inman, RD; McKibbon, C; Thomson, GT, 1994)
"Azathioprine (AZ) has been used in the treatment of refractory inflammatory bowel disease."1.28Azathioprine reduces extravasation and neutrophil trafficking in immune complex-mediated inflammation in the rat colon. ( Anania, T; Clearfield, HR; Murthy, SN, 1991)
"Treatment with prednisone or 5-aminosalicylic acid reduced TXB2 levels in the chronic stage of the inflammatory disease and improved the morphological damage as assessed macroscopically and histologically."1.28Participation of thromboxane and other eicosanoid synthesis in the course of experimental inflammatory colitis. ( Guarner, F; Malagelada, JR; Rodriguez, R; Salas, A; Vilaseca, J, 1990)
"Collagenous colitis is a rare condition characterized clinically by chronic diarrhea and histologically by a thickened subepithelial collagenous band in colonic biopsies in an endoscopically normal colon."1.28Familial occurrence of collagenous colitis. A report of two families. ( Blok, P; Dekker, W; Lam, HG; Meuwissen, SG; Seldenrijk, CA; Stel, HV; van Tilburg, AJ, 1990)

Research

Studies (223)

TimeframeStudies, this research(%)All Research%
pre-199012 (5.38)18.7374
1990's43 (19.28)18.2507
2000's64 (28.70)29.6817
2010's70 (31.39)24.3611
2020's34 (15.25)2.80

Authors

AuthorsStudies
Rousseaux, C2
Lefebvre, B1
Dubuquoy, L2
Lefebvre, P1
Romano, O1
Auwerx, J1
Metzger, D1
Wahli, W1
Desvergne, B1
Naccari, GC1
Chavatte, P3
Farce, A1
Bulois, P1
Cortot, A1
Colombel, JF2
Desreumaux, P4
Dhaneshwar, SS4
Kandpal, M3
Vadnerkar, G4
Rathi, B2
Kadam, SS2
Gairola, N2
Bhatt, L2
Chail, M1
Patil, M1
Naqvi, S1
Andrzejak, V2
Muccioli, GG2
Body-Malapel, M2
El Bakali, J2
Djouina, M2
Renault, N1
Lambert, DM2
Millet, R2
Kim, J1
Kang, S1
Hong, S2
Yum, S1
Kim, YM3
Jung, Y9
Gilleron, P1
Mansouri, R1
Barczyk, A1
Klupsch, F1
Lipka, E1
Furman, C1
Xi, M1
Ge, J1
Wang, X3
Sun, C1
Liu, T1
Fang, L1
Xiao, Q1
Yin, D1
Kadayat, TM2
Banskota, S2
Gurung, P2
Bist, G2
Thapa Magar, TB1
Shrestha, A2
Kim, JA3
Lee, ES2
Magar, TBT1
Tian, X1
Gao, J2
Liu, M3
Lei, Y1
Wang, F1
Chen, J4
Chu, P1
Long, F1
Liang, M1
Long, X1
Chu, H1
Liu, C1
Li, X1
Sun, Q1
Li, G1
Yang, Y6
Karmacharya, U1
Regmi, SC1
Awasthi, BP1
Chaudhary, P1
Kim, YE1
Lee, IH1
Nam, TG1
Jeong, BS1
Kido, M1
Tamura, R1
Yasui, Y1
Okajima, H1
Tian, W1
Xu, X1
Zheng, Z1
Liu, S1
Ying, J1
Zhang, X2
Guo, W2
Zeng, M2
Zhu, S1
Li, S3
Qian, Y1
Wu, H2
Ashour, RH1
Hazem, NM1
AbdElfattah, AA1
El-Kady, RA1
Elmasry, A1
Huang, Y1
Wu, M1
Xiao, H1
Liu, H2
Yang, G1
Huang, L1
Zheng, J1
Sun, G1
Yang, H2
Sun, X1
Yao, X1
Lin, A1
Hollander, B1
Khurana, S1
Jacob, JS1
Altan, M1
Wang, J2
Zhao, D1
Varatharajalu, K1
Alasadi, M1
Thomas, AS1
Wang, Y1
Huang, S2
Xie, X1
Su, Y1
Pan, Z1
Li, Y3
Liang, J2
Zhang, M1
Pan, S1
Xu, B1
Li, L1
Luo, X1
Zhou, L3
Yaguchi, K1
Matsune, Y1
Kunisaki, R1
Araki, K1
Kimura, H1
Inayama, Y1
Kumagai, J1
Maeda, S1
Yuan, N1
Chai, Y1
Song, Y1
Zhao, Y1
Cheng, C1
Hu, J3
Ji, Y1
Lian, Z1
Au, R1
Xu, F1
Li, W1
Shen, H1
Zhu, L1
Tange, K1
Yagi, S1
Takeshita, E1
Abe, M1
Yamamoto, Y1
Tomida, H1
Kawamura, T1
Hanayama, M1
Matsuura, B1
Ikeda, Y1
Hiasa, Y1
Chen, K1
Shang, S1
Yu, S1
Cui, L1
He, N1
Liu, YH2
Rong, ZL2
Zhu, HY2
Li, YT2
You, Y2
Chung, KS1
Park, SE1
Lee, JH1
Kim, SY2
Han, HS1
Lee, YS1
Jung, SH1
Jang, E1
Lee, S3
Lee, KT1
Abdelsameea, AA1
Alsemeh, AE1
Alabassery, N1
Samy, W1
Fawzy, A1
Abbas, NAT1
Yue, LI1
Shuting, W1
Runyuan, Z1
Dongmei, F1
Dike, Z1
Fengbin, L1
Hong, MI1
Fu, W1
Xie, L1
Yu, J1
He, Y1
Zeng, J2
Liu, J1
Liang, K1
Chen, P1
Jiang, L1
Gu, Z1
Kong, B1
Cong, J1
Wang, P1
Gai, H1
Zhou, S1
Zhang, Y1
Zhao, T1
Wada, H1
Miyoshi, J1
Kuronuma, S1
Nishinarita, Y1
Oguri, N1
Hibi, N1
Takeuchi, O1
Akimoto, Y1
Lee, STM1
Matsuura, M1
Kobayashi, T3
Hibi, T1
Hisamatsu, T1
Meunier, M1
Spillmann, A1
Schwamborn, K1
Hanson, M1
Rana, VS1
Mahajan, G1
Patil, AN1
Singh, AK1
Jearth, V1
Sekar, A1
Singh, H1
Saroch, A1
Dutta, U1
Sharma, V1
Do, HJ1
Kim, YS1
Oh, TW1
Krajewska, JB1
Pietruszka, P1
Tomczyk, D1
Chen, C1
Owczarek, A1
Karolewicz, B1
Czapor-Irzabek, H1
Gorniak, A1
Fichna, J1
Li, H1
He, L1
Du, X1
Xiong, Q1
Lai, X1
Hou, S1
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Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Prevalence of Segmental Colitis Associated With Colic Diverticulosis (SCAD): an Observational Study[NCT04279821]50 participants (Anticipated)Observational2020-02-01Recruiting
A Prospective, Randomized, Double-blind, Parallel, Placebo-controlled, Multi-center Study to Investigate the Efficacy and Safety of Apomivir® in Relieving Influenza Symptoms[NCT01677689]Phase 2196 participants (Anticipated)Interventional2018-09-01Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

22 reviews available for mesalamine and Colitis

ArticleYear
Antioxidant and anti-inflammatory protective effects of yellowtail (
    Food & function, 2022, Sep-22, Volume: 13, Issue:18

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Arginine; Caco-2 Cells; Claudin-4; Colitis; Cycloox

2022
Effects of 5-aminosalicylates or thiopurines on the progression of low-grade dysplasia in patients with inflammatory bowel disease: a systematic review and meta-analysis.
    International journal of colorectal disease, 2021, Volume: 36, Issue:1

    Topics: Colitis; Colorectal Neoplasms; Humans; Inflammatory Bowel Diseases; Mesalamine; Risk Factors

2021
New Insights of Oral Colonic Drug Delivery Systems for Inflammatory Bowel Disease Therapy.
    International journal of molecular sciences, 2020, Sep-05, Volume: 21, Issue:18

    Topics: Administration, Oral; Aminosalicylic Acids; Animals; Colitis; Colon; Drug Delivery Systems; Drug Lib

2020
Risk Factors for Vitamin D Deficiency in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.
    The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2021, Volume: 32, Issue:6

    Topics: Biological Products; Colitis; Crohn Disease; Humans; Inflammatory Bowel Diseases; Male; Mesalamine;

2021
Differential response of flat and polypoid colitis-associated colorectal neoplasias to chemopreventive agents and heterocyclic amines.
    Cancer letters, 2013, Jun-28, Volume: 334, Issue:1

    Topics: Amines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Carcinogens; Cell Proliferation

2013
Segmental colitis associated with diverticulosis: systematic evaluation of 486 cases with meta-analysis.
    Hepato-gastroenterology, 2012, Volume: 59, Issue:119

    Topics: Abdominal Pain; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Biopsy; Colitis; Colonosco

2012
Actual Usage and Quality of Experimental Colitis Models in Preclinical Efficacy Testing: A Scoping Review.
    Inflammatory bowel diseases, 2016, Volume: 22, Issue:6

    Topics: Adrenal Cortex Hormones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomedical Research; Coli

2016
Recent advances in clinical practice: a systematic review of isolated colonic Crohn's disease: the third IBD?
    Gut, 2017, Volume: 66, Issue:2

    Topics: Adalimumab; Adrenal Cortex Hormones; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal;

2017
Conventional medical management of inflammatory bowel disease.
    Gastroenterology, 2011, Volume: 140, Issue:6

    Topics: Adrenal Cortex Hormones; Algorithms; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroid

2011
Eosinophilic-Crohn overlap colitis and review of the literature.
    Journal of Crohn's & colitis, 2011, Volume: 5, Issue:3

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Crohn Disease; Eosinophilia; Humans; Male; M

2011
Aminosalicylates.
    Digestive diseases (Basel, Switzerland), 2012, Volume: 30, Issue:1

    Topics: Aminosalicylic Acids; Anti-Inflammatory Agents; Colitis; Diverticulitis, Colonic; Humans; Mesalamine

2012
[A case of acute phase ulcerative colitis like colitis developed by the interferon-beta therapy for chronic hepatitis C].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 2003, Volume: 100, Issue:6

    Topics: Acute-Phase Reaction; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colitis, Ulcerative; Colonos

2003
Nitric oxide-releasing mesalamine: potential utility for treatment of inflammatory bowel disease.
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2003, Volume: 35 Suppl 2

    Topics: Aminosalicylic Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Colitis; Cytokine

2003
Collagenous colitis evolving into ulcerative colitis: a case report and review of the literature.
    Digestive diseases and sciences, 2003, Volume: 48, Issue:12

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colitis, Ulcerative; Colonoscopy; Diagnosis, Diffe

2003
Review article: the chemoprevention of colorectal carcinoma.
    Alimentary pharmacology & therapeutics, 2004, Volume: 20 Suppl 4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Aspirin; Chemoprevention; Chromosoma

2004
Collagenous and lymphocytic colitis: subject review and therapeutic alternatives.
    The American journal of gastroenterology, 1995, Volume: 90, Issue:9

    Topics: Algorithms; Aminosalicylic Acids; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Colitis;

1995
[The local therapy of distal colitis and ulcerative proctitis].
    Deutsche medizinische Wochenschrift (1946), 1993, May-21, Volume: 118, Issue:20

    Topics: Administration, Rectal; Aminosalicylic Acids; Colitis; Colitis, Ulcerative; Cromolyn Sodium; Fatty A

1993
[Non-immunoallergic hepatotoxicity due to mesalazine].
    Gastroenterologia y hepatologia, 1999, Volume: 22, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Colitis; Diagnosis,

1999
[Therapeutic principles for chronic inflammatory bowel disease].
    Ugeskrift for laeger, 2001, Jan-01, Volume: 163, Issue:1

    Topics: Adjuvants, Immunologic; Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Colectomy; Colitis; C

2001
Possible mesalamine-induced pericarditis: case report and literature review.
    Pharmacotherapy, 2002, Volume: 22, Issue:3

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Chest Pain; Colitis; Female; Humans; Mesalamine; Per

2002
Oral 5-aminosalicyclic acid in children with colonic chronic inflammatory bowel disease: clinical and pharmacokinetic experience.
    Journal of pediatric gastroenterology and nutrition, 1989, Volume: 8, Issue:3

    Topics: Administration, Oral; Adolescent; Aminosalicylic Acids; Chronic Disease; Colitis; Drug Tolerance; Fe

1989
[Management of refractory and fulminating colitis].
    Duodecim; laaketieteellinen aikakauskirja, 1987, Volume: 103, Issue:14

    Topics: Aminosalicylic Acids; Colitis; Crohn Disease; Glucocorticoids; Humans; Mesalamine; Severity of Illne

1987

Trials

8 trials available for mesalamine and Colitis

ArticleYear
Use of the 'nutriceutical', bovine colostrum, for the treatment of distal colitis: results from an initial study.
    Alimentary pharmacology & therapeutics, 2002, Volume: 16, Issue:11

    Topics: Adolescent; Adult; Aged; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cattle; Colitis; Colostru

2002
Double-blind pilot study of mesalamine vs. placebo for treatment of chronic diarrhea and nonspecific colitis in immunocompetent HIV patients.
    Digestive diseases and sciences, 2006, Volume: 51, Issue:1

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Chronic Disease; Colitis; Colonoscopy; Diarr

2006
Response to treatment of microscopic colitis.
    The Italian journal of gastroenterology, 1994, Volume: 26, Issue:5

    Topics: Aminosalicylic Acids; Colitis; Colon; Diarrhea; Drug Therapy, Combination; Eosinophils; Female; Foll

1994
Mesalazine (Mesasal/Claversal) 1.5 g b.d. vs. placebo in the maintenance of remission of patients with Crohn's disease.
    Alimentary pharmacology & therapeutics, 1995, Volume: 9, Issue:6

    Topics: Adult; Aged; Aminosalicylic Acids; Anti-Inflammatory Agents, Non-Steroidal; Canada; Colitis; Crohn D

1995
Mesalazine (5-aminosalicylic acid) suppositories in the treatment of ulcerative proctitis or distal proctosigmoiditis. A randomized controlled trial.
    Scandinavian journal of gastroenterology, 1990, Volume: 25, Issue:7

    Topics: Adult; Aminosalicylic Acids; Colitis; Double-Blind Method; Female; Humans; Male; Mesalamine; Multice

1990
[Effects of corticoids, 5-aminosalycilic acid and sucralfate on the potential difference of the rectum in inflammatory colitis in man].
    Gastroenterologie clinique et biologique, 1989, Volume: 13, Issue:2

    Topics: Action Potentials; Administration, Rectal; Aminosalicylic Acids; Colitis; Female; Humans; Hydrocorti

1989
Proctocolitis unresponsive to conventional therapy. Response to 5-aminosalicylic acid enemas.
    Digestive diseases and sciences, 1987, Volume: 32, Issue:12 Suppl

    Topics: Adult; Aminosalicylic Acids; Clinical Trials as Topic; Colitis; Enema; Female; Follow-Up Studies; Hu

1987
5-Aminosalicylic acid enema in the treatment of distal ulcerative colitis, proctosigmoiditis, and proctitis.
    Gastroenterology, 1987, Volume: 92, Issue:6

    Topics: Adult; Aminosalicylic Acids; Colitis; Colitis, Ulcerative; Enema; Female; Humans; Male; Mesalamine;

1987

Other Studies

193 other studies available for mesalamine and Colitis

ArticleYear
Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma.
    The Journal of experimental medicine, 2005, Apr-18, Volume: 201, Issue:8

    Topics: 3T3-L1 Cells; Animals; Anti-Inflammatory Agents; Colitis; Colon; Gene Expression Regulation; HT29 Ce

2005
Synthesis, kinetic studies and pharmacological evaluation of mutual azo prodrug of 5-aminosalicylic acid for colon-specific drug delivery in inflammatory bowel disease.
    European journal of medicinal chemistry, 2007, Volume: 42, Issue:6

    Topics: Aminosalicylic Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colon; Female; Male

2007
Colon-specific, mutual azo prodrug of 5-aminosalicylic acid with L-tryptophan: synthesis, kinetic studies and evaluation of its mitigating effect in trinitrobenzenesulfonic acid-induced colitis in rats.
    Bioorganic & medicinal chemistry, 2007, Jul-15, Volume: 15, Issue:14

    Topics: Animals; Azo Compounds; Body Weight; Colitis; Kinetics; Mesalamine; Molecular Structure; Organ Size;

2007
Colon-specific mutual amide prodrugs of 4-aminosalicylic acid for their mitigating effect on experimental colitis in rats.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:1

    Topics: Aminosalicylic Acids; Animals; Colitis; Colon; Drug Delivery Systems; Drug Stability; Drug-Related S

2009
Synthesis, kinetic studies and pharmacological evaluation of mutual azo prodrugs of 5-aminosalicylic acid for colon-specific drug delivery in inflammatory bowel disease.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:10

    Topics: Aminosalicylic Acids; Animals; Arthritis; Colitis; Colon; Female; Inflammatory Bowel Diseases; Male;

2009
New FAAH inhibitors based on 3-carboxamido-5-aryl-isoxazole scaffold that protect against experimental colitis.
    Bioorganic & medicinal chemistry, 2011, Jun-15, Volume: 19, Issue:12

    Topics: Amidohydrolases; Animals; Colitis; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Hum

2011
Structure-activity relationship of salicylic acid derivatives on inhibition of TNF-α dependent NFκB activity: Implication on anti-inflammatory effect of N-(5-chlorosalicyloyl)phenethylamine against experimental colitis.
    European journal of medicinal chemistry, 2012, Volume: 48

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Survival; Chemokine CXCL2; Colitis; HCT116 Ce

2012
4-Oxo-1,4-dihydropyridines as selective CB₂ cannabinoid receptor ligands. Part 2: discovery of new agonists endowed with protective effect against experimental colitis.
    Journal of medicinal chemistry, 2012, Oct-25, Volume: 55, Issue:20

    Topics: Adamantane; Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding, Competitive; Blood Proteins;

2012
Development of hydroxy-based sphingosine kinase inhibitors and anti-inflammation in dextran sodium sulfate induced colitis in mice.
    Bioorganic & medicinal chemistry, 2016, 07-15, Volume: 24, Issue:14

    Topics: Animals; Colitis; Dextran Sulfate; Enzyme Inhibitors; HCT116 Cells; Humans; Mice; Phosphotransferase

2016
Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease.
    European journal of medicinal chemistry, 2017, Sep-08, Volume: 137

    Topics: Animals; Benzofurans; Colitis; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Discov

2017
Synthesis and biological evaluation of pyridine-linked indanone derivatives: Potential agents for inflammatory bowel disease.
    Bioorganic & medicinal chemistry letters, 2018, 08-01, Volume: 28, Issue:14

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Adhesion; Colitis; Dise

2018
Small-Molecule Antagonist Targeting Exportin-1 via Rational Structure-Based Discovery.
    Journal of medicinal chemistry, 2020, 04-23, Volume: 63, Issue:8

    Topics: Amino Acid Sequence; Animals; Colitis; Dose-Response Relationship, Drug; Drug Delivery Systems; Drug

2020
Synthesis and activity of N-(5-hydroxy-3,4,6-trimethylpyridin-2-yl)acetamide analogues as anticolitis agents via dual inhibition of TNF-α- and IL-6-induced cell adhesions.
    Bioorganic & medicinal chemistry letters, 2021, 07-01, Volume: 43

    Topics: Acetamides; Animals; Cell Adhesion; Colitis; Dose-Response Relationship, Drug; Interleukin-6; Molecu

2021
Novel application of infliximab for diversion colitis.
    BMJ case reports, 2021, Oct-01, Volume: 14, Issue:10

    Topics: Adult; Colectomy; Colitis; Colitis, Ulcerative; Humans; Infliximab; Male; Mesalamine; Treatment Outc

2021
Effects of jianguiqre decotion combined with mesalazine enteriic-coated tablets and bifid triple capsule dissolving at testines on the efficacy, TCM scores and inflammatory factors of patients with severe chronic colitis.
    Minerva surgery, 2022, Volume: 77, Issue:5

    Topics: Colitis; Colitis, Ulcerative; Humans; Mesalamine; Tablets

2022
Phycocyanin ameliorates mouse colitis
    Food & function, 2022, Mar-21, Volume: 13, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Caco-2 Cells; Colitis; Epithelial Ce

2022
Pentosan Polysulfate Sodium augments the therapeutic effect of 5-Aminosalicylic Acid in DSS colitis model; the role of IL-35 expression.
    International immunopharmacology, 2022, Volume: 106

    Topics: Animals; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Animal; Female; Inter

2022
Mesalamine-Mediated Amelioration of Experimental Colitis in Piglets Involves Gut Microbiota Modulation and Intestinal Immune Cell Infiltration.
    Frontiers in immunology, 2022, Volume: 13

    Topics: Animals; Colitis; Colitis, Ulcerative; Dextran Sulfate; Gastrointestinal Microbiome; Mesalamine; Swi

2022
5-Aminosalicylic acid ameliorates dextran sulfate sodium-induced colitis in mice by modulating gut microbiota and bile acid metabolism.
    Cellular and molecular life sciences : CMLS, 2022, Aug-01, Volume: 79, Issue:8

    Topics: Animals; Bile Acids and Salts; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Gastrointest

2022
Mesalamine and cholestyramine for immune checkpoint inhibitor-mediated diarrhea and colitis.
    Journal of cancer research and clinical oncology, 2023, Volume: 149, Issue:7

    Topics: Adult; Cholestyramine Resin; Colitis; Diarrhea; Female; Humans; Immune Checkpoint Inhibitors; Immuno

2023
Dahuang Mudan decoction repairs intestinal barrier in chronic colitic mice by regulating the function of ILC3.
    Journal of ethnopharmacology, 2022, Dec-05, Volume: 299

    Topics: Animals; Body Weight; Caco-2 Cells; Claudin-1; Colitis; Colitis, Ulcerative; Culture Media, Conditio

2022
Progression of ulcerative colitis following diversion colitis.
    Clinical journal of gastroenterology, 2022, Volume: 15, Issue:6

    Topics: Colitis; Colitis, Ulcerative; Colonoscopy; Diverticulum, Colon; Humans; Male; Mesalamine; Middle Age

2022
Qing-Chang-Hua-Shi granule ameliorates DSS-induced colitis by activating NLRP6 signaling and regulating Th17/Treg balance.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2022, Volume: 107

    Topics: Animals; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Drugs, Chinese Herbal; Inflammasomes;

2022
Oral administration of human carbonic anhydrase I suppresses colitis in a murine inflammatory bowel disease model.
    Scientific reports, 2022, 10-26, Volume: 12, Issue:1

    Topics: Administration, Oral; Animals; Carbonic Anhydrase I; Colitis; Disease Models, Animal; Humans; Inflam

2022
Identification and exploration of pharmacological pyroptosis-related biomarkers of ulcerative colitis.
    Frontiers in immunology, 2022, Volume: 13

    Topics: Animals; Biomarkers, Pharmacological; Colitis; Colitis, Ulcerative; Dextran Sulfate; Mesalamine; Mic

2022
[Mechanism of Shenling Baizhu Powder on treatment of ulcerative colitis based on NLRP3 inflammatory].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2022, Volume: 47, Issue:21

    Topics: Animals; Caspase 1; Colitis; Colitis, Ulcerative; Colon; Cytokines; Dextran Sulfate; Disease Models,

2022
[Mechanism of Shenling Baizhu Powder on treatment of ulcerative colitis based on NLRP3 inflammatory].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2022, Volume: 47, Issue:21

    Topics: Animals; Caspase 1; Colitis; Colitis, Ulcerative; Colon; Cytokines; Dextran Sulfate; Disease Models,

2022
[Mechanism of Shenling Baizhu Powder on treatment of ulcerative colitis based on NLRP3 inflammatory].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2022, Volume: 47, Issue:21

    Topics: Animals; Caspase 1; Colitis; Colitis, Ulcerative; Colon; Cytokines; Dextran Sulfate; Disease Models,

2022
[Mechanism of Shenling Baizhu Powder on treatment of ulcerative colitis based on NLRP3 inflammatory].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2022, Volume: 47, Issue:21

    Topics: Animals; Caspase 1; Colitis; Colitis, Ulcerative; Colon; Cytokines; Dextran Sulfate; Disease Models,

2022
Protective effect of 7-hydroxyl-1-methylindole-3-acetonitrile on the intestinal mucosal damage response to inflammation in mice with DSS-induced colitis.
    Chemico-biological interactions, 2023, Jan-25, Volume: 370

    Topics: Animals; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Animal; Drinking Wate

2023
Icosapent ethyl alleviates acetic acid-induced ulcerative colitis via modulation of SIRT1 signaling pathway in rats.
    International immunopharmacology, 2023, Volume: 115

    Topics: Acetic Acid; Animals; Caspase 3; Colitis; Colitis, Ulcerative; Collagen; Colon; Eicosapentaenoic Aci

2023
Efficacy of active ingredients in Qingdai on ulcerative colitis: a network pharmacology-based evaluation.
    Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2023, Volume: 43, Issue:1

    Topics: Animals; Colitis; Colitis, Ulcerative; Colon; Disease Models, Animal; Glycogen Synthase Kinase 3; Me

2023
    ACS applied materials & interfaces, 2023, Feb-08, Volume: 15, Issue:5

    Topics: Animals; Colitis; Drug Delivery Systems; Mesalamine; Mice; Plants; Zebrafish

2023
Effects of compound prebiotics as prophylactic and therapeutic supplementation in a mouse model of acute colitis.
    Applied microbiology and biotechnology, 2023, Volume: 107, Issue:7-8

    Topics: Animals; Colitis; Colon; Disease Models, Animal; Mesalamine; Mice; Mice, Inbred C57BL; Phylogeny; Pr

2023
5-Aminosalicylic acid alters the gut microbiota and altered microbiota transmitted vertically to offspring have protective effects against colitis.
    Scientific reports, 2023, 07-28, Volume: 13, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Mod

2023
An oral cholera vaccine in the prevention and/or treatment of inflammatory bowel disease.
    PloS one, 2023, Volume: 18, Issue:8

    Topics: Animals; Cholera Vaccines; Colitis; Inflammatory Bowel Diseases; Lipopolysaccharides; Mesalamine; Mi

2023
Factors contributing to flares of ulcerative colitis in North India- a case-control study.
    BMC gastroenterology, 2023, Sep-28, Volume: 23, Issue:1

    Topics: Adult; Anti-Bacterial Agents; Case-Control Studies; Colitis; Colitis, Ulcerative; Female; Humans; In

2023
Effect of Polycan, a β-Glucan from
    International journal of molecular sciences, 2023, Sep-30, Volume: 24, Issue:19

    Topics: Animals; beta-Glucans; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Dextrans; Disease Model

2023
Evaluation of the effect of liposomes loaded with chlorogenic acid in treatment of 2,4,6-trinitrobenzenesulfonic acid-induced murine colitis.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2019, Volume: 70, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Chlorogenic Acid; Colitis; Colon; Disease Models, Animal; Inflamm

2019
Dendrobium officinale polysaccharides alleviate colon tumorigenesis via restoring intestinal barrier function and enhancing anti-tumor immune response.
    Pharmacological research, 2019, Volume: 148

    Topics: Animals; Antineoplastic Agents; Carcinogenesis; CD8-Positive T-Lymphocytes; Colitis; Colon; Colorect

2019
Intestinal inflammation increases convulsant activity and reduces antiepileptic drug efficacy in a mouse model of epilepsy.
    Scientific reports, 2019, 09-27, Volume: 9, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Colitis; Convulsants; Dextran Sul

2019
5-Aminosalicylic Acid Azo-Coupled with a GPR109A Agonist Is a Colon-Targeted Anticolitic Codrug with a Reduced Risk of Skin Toxicity.
    Molecular pharmaceutics, 2020, 01-06, Volume: 17, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumor; Chromatography, Liquid; Colitis;

2020
Targeting IL-10, ZO-1 gene expression and IL-6/STAT-3 trans-signalling by a combination of atorvastatin and mesalazine to enhance anti-inflammatory effects and attenuate progression of oxazolone-induced colitis.
    Fundamental & clinical pharmacology, 2021, Volume: 35, Issue:1

    Topics: Anti-Inflammatory Agents; Atorvastatin; Colitis; Gene Expression; Humans; Interleukin-10; Interleuki

2021
5-Aminosalicylic Acid Ameliorates Colitis and Checks Dysbiotic Escherichia coli Expansion by Activating PPAR-γ Signaling in the Intestinal Epithelium.
    mBio, 2021, 01-19, Volume: 12, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colon; Cytochrome b Group; Dextran Sulfat

2021
Inhibition of PD-1 Protects against TNBS-Induced Colitis via Alteration of Enteric Microbiota.
    BioMed research international, 2021, Volume: 2021

    Topics: Animals; Colitis; Colon; Disease Models, Animal; Gastrointestinal Microbiome; Immune Checkpoint Inhi

2021
Thermosensitive polymer hydrogel as a physical shield on colonic mucosa for colitis treatment.
    Journal of materials chemistry. B, 2021, 05-12, Volume: 9, Issue:18

    Topics: Animals; Biocompatible Materials; Colitis; Disease Models, Animal; Drug Carriers; Drug Liberation; H

2021
Identification of a new azoreductase driven prodrug from bardoxolone methyl and 5-aminosalicylate for the treatment of colitis in mice.
    Chinese journal of natural medicines, 2021, Volume: 19, Issue:7

    Topics: Animals; Colitis; Mesalamine; Mice; Nitroreductases; Oleanolic Acid; Prodrugs

2021
Comparison of anti-inflammatory activities of an anthocyanin-rich fraction from Portuguese blueberries (Vaccinium corymbosum L.) and 5-aminosalicylic acid in a TNBS-induced colitis rat model.
    PloS one, 2017, Volume: 12, Issue:3

    Topics: Animals; Anthocyanins; Anti-Inflammatory Agents; Antioxidants; Blueberry Plants; Colitis; Colon; Cyc

2017
Acetylsalicylic acid-tris-hydroxymethyl-aminomethane reduces colon mucosal damage without causing gastric side effects in a rat model of colitis.
    Inflammopharmacology, 2018, Volume: 26, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colitis; Colon; Disease Models, Animal; I

2018
Editorial: evidence is growing for protective effects of 5-aminosalicylates against colitis-associated cancer-authors' reply.
    Alimentary pharmacology & therapeutics, 2017, Volume: 45, Issue:12

    Topics: Colitis; Colitis, Ulcerative; Humans; Mesalamine; Neoplasms

2017
Editorial: evidence is growing for protective effects of 5-aminosalicylates against colitis-associated cancer.
    Alimentary pharmacology & therapeutics, 2017, Volume: 45, Issue:12

    Topics: Colitis; Colitis, Ulcerative; Humans; Mesalamine; Neoplasms

2017
Effect of roxithromycin on mucosal damage, oxidative stress and pro-inflammatory markers in experimental model of colitis.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2018, Volume: 67, Issue:2

    Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Diclofenac; Edema;

2018
Antioxidant and anti-inflammatory effect of plumieride in dextran sulfate sodium-induced colitis in mice.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 99

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apocynaceae; Cell Line; Colitis; Colitis, Ulcerativ

2018
A colon-specific prodrug of metoclopramide ameliorates colitis in an experimental rat model.
    Drug design, development and therapy, 2019, Volume: 13

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Azo Compounds; Benzenesulfon

2019
Mesalamine and azathioprine modulate junctional complexes and restore epithelial barrier function in intestinal inflammation.
    Scientific reports, 2019, 02-26, Volume: 9, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Colitis; Epithelial Cells; Inflammat

2019
Improvement of the therapeutic treatment of inflammatory bowel diseases following rectal administration of mesalazine-loaded chitosan microparticles vs Asamax
    Carbohydrate polymers, 2019, May-15, Volume: 212

    Topics: Administration, Rectal; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caco-2 Cells; Cell Surviva

2019
Mesalazine Activates Adenosine Monophosphate-activated Protein Kinase: Implication in the Anti-inflammatory Activity of this Anti-colitic Drug.
    Current molecular pharmacology, 2019, Volume: 12, Issue:4

    Topics: AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Enzyme Act

2019
Double Drug Delivery Using Capped Mesoporous Silica Microparticles for the Effective Treatment of Inflammatory Bowel Disease.
    Molecular pharmaceutics, 2019, 06-03, Volume: 16, Issue:6

    Topics: Animals; Colitis; Drug Delivery Systems; Hydrocortisone; Inflammatory Bowel Diseases; Male; Mesalami

2019
Enemas with mesalazine increase the tissue contents of mucins in the colonic mucosa devoid of fecal stream.
    Acta cirurgica brasileira, 2019, Apr-29, Volume: 34, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colon; Colostomy; Enema; Feces; Gastroint

2019
Therapeutic effectiveness of rectally administered fish oil and mesalazine in trinitrobenzenesulfonic acid-induced colitis.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 118

    Topics: Animals; Colitis; Cytokines; Fish Oils; Intestinal Mucosa; Mesalamine; Oxidative Stress; Rats, Wista

2019
Comparative protective effect of hawthorn berry hydroalcoholic extract, atorvastatin, and mesalamine on experimentally induced colitis in rats.
    Journal of medicinal food, 2013, Volume: 16, Issue:7

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Atorvastatin; Colitis; Crataegus; Fruit; Heptanoic

2013
[A case of diversion colitis successfully treated with 5-aminosalicylic acid].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 2013, Volume: 110, Issue:8

    Topics: Aged, 80 and over; Colectomy; Colitis; Enema; Humans; Ileostomy; Male; Mesalamine; Postoperative Com

2013
Design and development of novel azo prodrugs using various permutations and combinations of 5- and 4-aminosalicylic acids for inflammatory bowel disease: a colon-targeted approach.
    Inflammation & allergy drug targets, 2013, Volume: 12, Issue:5

    Topics: Aminosalicylic Acid; Animals; Azo Compounds; Colitis; Colon; Drug Design; Female; Humans; Inflammato

2013
Eosinophilic colitis is a sporadic self-limited disease of middle-aged people: a population-based study.
    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, 2014, Volume: 16, Issue:2

    Topics: Abdominal Pain; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Cohort Studies; Colitis; Colon

2014
Heat-killed VSL#3 ameliorates dextran sulfate sodium (DSS)-induced acute experimental colitis in rats.
    International journal of molecular sciences, 2013, Dec-19, Volume: 15, Issue:1

    Topics: Acute Disease; Animals; Colitis; Dextran Sulfate; Disease Models, Animal; Hot Temperature; Interleuk

2013
Acute murine colitis reduces colonic 5-aminosalicylic acid metabolism by regulation of N-acetyltransferase-2.
    American journal of physiology. Gastrointestinal and liver physiology, 2014, Jun-01, Volume: 306, Issue:11

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arylamine N-Acetyltransferase; Colitis; Colon; Dex

2014
Effect of mesalamine and prednisolone on TNBS experimental colitis, following various doses of orally administered iron.
    BioMed research international, 2014, Volume: 2014

    Topics: Administration, Oral; Animals; Colitis; Dietary Supplements; Dose-Response Relationship, Drug; Intes

2014
Arctigenin but not arctiin acts as the major effective constituent of Arctium lappa L. fruit for attenuating colonic inflammatory response induced by dextran sulfate sodium in mice.
    International immunopharmacology, 2014, Volume: 23, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arctium; Colitis; Dextran Sulfate; Dose-Response R

2014
Amelioration of trinitrobenzene sulfonic acid-induced colitis in mice by liquiritigenin.
    Journal of gastroenterology and hepatology, 2015, Volume: 30, Issue:5

    Topics: Animals; Anti-Inflammatory Agents; Colitis; Colon; Cytokines; Disease Models, Animal; Dose-Response

2015
In vivo efficacy of microbiota-sensitive coatings for colon targeting: a promising tool for IBD therapy.
    Journal of controlled release : official journal of the Controlled Release Society, 2015, Jan-10, Volume: 197

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cellulose; Colitis; Colon; Dextrins; Drug Delivery

2015
In Vivo Evaluation of 5-ASA Colon-Specific Tablets Using Experimental-Induced Colitis Rat Animal Model.
    AAPS PharmSciTech, 2015, Volume: 16, Issue:6

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceutical; C

2015
Dextran-5-(4-ethoxycarbonylphenylazo)salicylic acid ester, a polymeric colon-specific prodrug releasing 5-aminosalicylic acid and benzocaine, ameliorates TNBS-induced rat colitis.
    Journal of drug targeting, 2016, Volume: 24, Issue:5

    Topics: Administration, Oral; Animals; Benzocaine; Cecum; Colitis; Colon; Dextrans; Inflammation Mediators;

2016
A case of diverticular colitis with lesions resembling ulcerative colitis and correlation of tumor necrosis factor-alpha staining with clinical manifestations.
    Clinical journal of gastroenterology, 2015, Volume: 8, Issue:6

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colitis, Ulcerative; Colonoscopy; Diverticulum, Co

2015
Suppression of colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway by balsalazide and VSL#3.
    Journal of gastroenterology and hepatology, 2016, Volume: 31, Issue:8

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Azoxymethane; bcl-2-Assoc

2016
1,25-hydroxyvitamin D relieves colitis in rats via down-regulation of toll-like receptor 9 expression.
    Croatian medical journal, 2015, Volume: 56, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Disease Models, Animal; Down-Regulation;

2015
5-Aminosalicylic Acid Azo-Linked to Procainamide Acts as an Anticolitic Mutual Prodrug via Additive Inhibition of Nuclear Factor kappaB.
    Molecular pharmaceutics, 2016, 06-06, Volume: 13, Issue:6

    Topics: Animals; Azo Compounds; Colitis; Colon; Male; Mesalamine; NF-kappa B; Procainamide; Prodrugs; Rats;

2016
Mucoadhesive microparticulates based on polysaccharide for target dual drug delivery of 5-aminosalicylic acid and curcumin to inflamed colon.
    Colloids and surfaces. B, Biointerfaces, 2016, Sep-01, Volume: 145

    Topics: Animals; Chitosan; Colitis; Colon; Curcumin; Drug Carriers; Inflammatory Bowel Diseases; Mesalamine;

2016
Surgical Treatment of Crohn Colitis Involving More Than 2 Colonic Segments: Long-Term Outcomes From a Single Institution.
    Medicine, 2016, Volume: 95, Issue:22

    Topics: Adult; Age of Onset; Colectomy; Colitis; Crohn Disease; Female; Humans; Immunosuppressive Agents; Ma

2016
Discovery and preclinical development of a novel prodrug conjugate of mesalamine with eicosapentaenoic acid and caprylic acid for the treatment of inflammatory bowel diseases.
    International immunopharmacology, 2016, Volume: 40

    Topics: Aminosalicylic Acids; Animals; Caprylates; Colitis; Colon; Dextran Sulfate; Drug Discovery; Drug Eva

2016
Co-delivery of zinc and 5-aminosalicylic acid from alginate/N-succinyl-chitosan blend microspheres for synergistic therapy of colitis.
    International journal of pharmaceutics, 2017, Jan-10, Volume: 516, Issue:1-2

    Topics: Administration, Oral; Alginates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chitosan; Colitis

2017
The effects of aminosalicylates or thiopurines on the risk of colorectal cancer in inflammatory bowel disease.
    Alimentary pharmacology & therapeutics, 2017, Volume: 45, Issue:4

    Topics: Adult; Aged; Aminosalicylic Acids; Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Co

2017
IBD-Like Features in Syndromic Diarrhea/Trichohepatoenteric Syndrome.
    Journal of pediatric gastroenterology and nutrition, 2017, Volume: 64, Issue:1

    Topics: Anti-Inflammatory Agents; Biological Therapy; Colitis; Colon; Diarrhea; Diarrhea, Infantile; Facies;

2017
Combined Parthenolide and Balsalazide Have Enhanced Antitumor Efficacy Through Blockade of NF-κB Activation.
    Molecular cancer research : MCR, 2017, Volume: 15, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Combined Chemotherapy Protocols; Ap

2017
Jianpi Qingchang decoction alleviates ulcerative colitis by inhibiting nuclear factor-κB activation.
    World journal of gastroenterology, 2017, Feb-21, Volume: 23, Issue:7

    Topics: Animals; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Drugs, Chinese Herbal; Inflammation;

2017
Luminal antioxidants enhance the effects of mesalamine in the treatment of chemically induced colitis in rats.
    Experimental biology and medicine (Maywood, N.J.), 2008, Volume: 233, Issue:10

    Topics: Animals; Antioxidants; Ascorbic Acid; Colitis; Cyclic N-Oxides; Disease Models, Animal; Drug Synergi

2008
Effects of N-acetylcysteine plus mesalamine on prostaglandin synthesis and nitric oxide generation in TNBS-induced colitis in rats.
    Digestive diseases and sciences, 2009, Volume: 54, Issue:4

    Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colon; Cyclooxygenase 1;

2009
The targeting of surface modified silica nanoparticles to inflamed tissue in experimental colitis.
    Biomaterials, 2008, Volume: 29, Issue:34

    Topics: Animals; Caco-2 Cells; Cell Line; Colitis; Colon; Disease Models, Animal; Drug Carriers; Drug Delive

2008
Poly(ethylene glycol)-mesalazine conjugate for colon specific delivery.
    International journal of pharmaceutics, 2009, Feb-23, Volume: 368, Issue:1-2

    Topics: Administration, Oral; Animals; Cell Line; Colitis; Colon; Delayed-Action Preparations; Dextran Sulfa

2009
Segmental colitis associated with diverticulosis syndrome.
    World journal of gastroenterology, 2008, Nov-14, Volume: 14, Issue:42

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Colitis; Diagnosis, Differential; Disease Progression; Dive

2008
Therapeutic effects of rectal administration of muscovite on experimental colitis in rats.
    Journal of gastroenterology and hepatology, 2009, Volume: 24, Issue:5

    Topics: Administration, Rectal; Aluminum Silicates; Animals; Anti-Inflammatory Agents; Body Weight; Colitis;

2009
[Effect of balsalazide on intestinal mucosal permeability of dextran sulfate sodium-induced colitis in mice].
    Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery, 2009, Volume: 12, Issue:2

    Topics: Animals; Colitis; Dextran Sulfate; Female; Intestinal Mucosa; Male; Mesalamine; Mice; Mice, Inbred C

2009
Therapeutic effects of Clostridium butyricum on experimental colitis induced by oxazolone in rats.
    World journal of gastroenterology, 2009, Apr-21, Volume: 15, Issue:15

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Butyrates; Calcitonin Gene-Related Peptide; Clostr

2009
Infliximab in the treatment of anti-CTLA4 antibody (ipilimumab) induced immune-related colitis.
    Cancer biotherapy & radiopharmaceuticals, 2009, Volume: 24, Issue:3

    Topics: Algorithms; Antibodies, Monoclonal; Antigens, CD; Clinical Trials as Topic; Colitis; CTLA-4 Antigen;

2009
Balsalazine decreases intestinal mucosal permeability of dextran sulfate sodium-induced colitis in mice.
    Acta pharmacologica Sinica, 2009, Volume: 30, Issue:7

    Topics: Animals; Colitis; Dextran Sulfate; Gastrointestinal Agents; Glutathione Peroxidase; Interferon-gamma

2009
An anti-inflammatory mechanism of taurine conjugated 5-aminosalicylic acid against experimental colitis: taurine chloramine potentiates inhibitory effect of 5-aminosalicylic acid on IL-1beta-mediated NFkappaB activation.
    European journal of pharmacology, 2009, Sep-15, Volume: 618, Issue:1-3

    Topics: Animals; Anti-Inflammatory Agents; Cell Line, Tumor; Colitis; Dose-Response Relationship, Drug; Drug

2009
Inhibition of colon carcinogenesis by 2-methoxy-5-amino-N-hydroxybenzamide, a novel derivative of mesalamine.
    Gastroenterology, 2010, Volume: 138, Issue:1

    Topics: Aminosalicylic Acids; Animals; Anticarcinogenic Agents; Azoxymethane; Benzamides; Carcinogens; Cell

2010
Oral administration of mesalazine protects against mucosal injury and permeation in dextran sulfate sodium-induced colitis in rats.
    Scandinavian journal of gastroenterology, 2009, Volume: 44, Issue:11

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Dextran Sulfate; Di

2009
[A case of segmental colitis associated with diverticular disease].
    The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 2010, Volume: 55, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colon, Sigmoid; Colonoscopy; Diverticulitis, Colon

2010
5-aminosalicylic acid (5-ASA) can reduce levels of oxidative DNA damage in cells of colonic mucosa with and without fecal stream.
    Digestive diseases and sciences, 2011, Volume: 56, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colon; DNA Damage; Feces; Hydrogen Peroxi

2011
[Paeoniflorin increases beta-defensin expression and attenuates lesion in the colonic mucosa from mice with oxazolone-induced colitis].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2010, Volume: 45, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoates; beta-Defensins; Bridged-Ring Compounds;

2010
The prevention of colitis-related cancer by 5-aminosalicylates: an appealing hypothesis that remains unproven.
    The American journal of gastroenterology, 2011, Volume: 106, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colorectal Neoplasms; Humans; Mesalamine; Models,

2011
Influence of Shenqing Recipe on morphology and quantity of colonic interstitial cells of Cajal in trinitrobenzene sulfonic acid induced rat colitis.
    Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih, 2011, Volume: 26, Issue:1

    Topics: Animals; Colitis; Colon; Drugs, Chinese Herbal; Interstitial Cells of Cajal; Male; Medicine, Chinese

2011
Protective effect of aqueous extract of Bombax malabaricum DC on experimental models of inflammatory bowel disease in rats and mice.
    Indian journal of experimental biology, 2011, Volume: 49, Issue:5

    Topics: Acetic Acid; Animals; Bombax; Colitis; Disease Models, Animal; Female; India; Indomethacin; Inflamma

2011
N-Succinyl-chitosan systems for 5-aminosalicylic acid colon delivery: in vivo study with TNBS-induced colitis model in rats.
    International journal of pharmaceutics, 2011, Sep-15, Volume: 416, Issue:1

    Topics: Absorption; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chitosan; Colitis; Colon; Disease Mode

2011
Beneficial effects of THSG on acetic acid-induced experimental colitis: involvement of upregulation of PPAR-γ and inhibition of the Nf-Κb inflammatory pathway.
    Molecules (Basel, Switzerland), 2011, Oct-12, Volume: 16, Issue:10

    Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Cyclooxygenase 2; Cyclooxyge

2011
Bioadhesive pellets increase local 5-aminosalicylic acid concentration in experimental colitis.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2012, Volume: 81, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Biopolymers; Chitosan; Colitis; Colon; Drug Delivery Systems; Dru

2012
Mucosal expression of basic fibroblastic growth factor, Syndecan 1 and tumor necrosis factor-alpha in diverticular disease of the colon: a case-control study.
    Neurogastroenterology and motility, 2012, Volume: 24, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Case

2012
Differential diagnosis and management of histologic eosinophilic colitis.
    Journal of Crohn's & colitis, 2013, Volume: 7, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Asthma; Blastocystis hominis; Blastocystis Infections; Coli

2013
An orally administered redox nanoparticle that accumulates in the colonic mucosa and reduces colitis in mice.
    Gastroenterology, 2012, Volume: 143, Issue:4

    Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Colitis; Colon

2012
Adjunct therapy of n-3 fatty acids to 5-ASA ameliorates inflammatory score and decreases NF-κB in rats with TNBS-induced colitis.
    The Journal of nutritional biochemistry, 2013, Volume: 24, Issue:4

    Topics: Animals; Colitis; Fatty Acids, Omega-3; Inflammation; Male; Mesalamine; NF-kappa B; PPAR gamma; Rats

2013
Effect of recombinant Lactobacillus casei expressing interleukin-10 in dextran sulfate sodium-induced colitis mice.
    Journal of digestive diseases, 2013, Volume: 14, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colon; Dextran Sulfate; Female; Interfero

2013
Exploiting the synergistic effect of chitosan-EDTA conjugate with MSA for the early recovery from colitis.
    International journal of biological macromolecules, 2013, Volume: 54

    Topics: Adhesiveness; Animals; Calorimetry, Differential Scanning; Chitosan; Colitis; Colon; Drug Synergism;

2013
Efficacy of drugs used in the treatment of IBD and combinations thereof in acute DSS-induced colitis in mice.
    Life sciences, 2013, Apr-09, Volume: 92, Issue:12

    Topics: Aminosalicylic Acids; Animals; Anti-Inflammatory Agents; Budesonide; Colitis; Colon; Cyclosporine; D

2013
Assessment of orocaecal transit time in different localization of Crohn's disease and its possible influence on clinical response to therapy.
    European journal of gastroenterology & hepatology, 2003, Volume: 15, Issue:1

    Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Breath Tests; Colitis; Crohn Disease; Delayed-

2003
Collagenous and lymphocytic colitis. evaluation of clinical and histological features, response to treatment, and long-term follow-up.
    The American journal of gastroenterology, 2003, Volume: 98, Issue:2

    Topics: Aged; Budesonide; Cholestyramine Resin; Colitis; Collagen; Colon; Female; Follow-Up Studies; Humans;

2003
Successful use of mesalamine in the treatment of chronic segmental lesion in a case of ischemic colitis.
    Journal of gastroenterology and hepatology, 2003, Volume: 18, Issue:7

    Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Colitis; Female;

2003
Collagenous colitis associated with Clostridium difficile: a cause effect?
    Digestive diseases and sciences, 2003, Volume: 48, Issue:7

    Topics: Aged; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Clostridioides difficile; Coli

2003
The intestinal anti-inflammatory activity of UR-12746S on reactivated experimental colitis is mediated through downregulation of cytokine production.
    Inflammatory bowel diseases, 2003, Volume: 9, Issue:6

    Topics: Aminosalicylic Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aza Compounds; Azo Compounds

2003
5-ASA and lycopene decrease the oxidative stress and inflammation induced by iron in rats with colitis.
    Journal of gastroenterology, 2004, Volume: 39, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; beta Carotene; Carotenoids; Colitis;

2004
Effect of mesalazine, metronidazole and gentamicin on bacterial translocation in experimental colitis.
    Journal of gastroenterology and hepatology, 2004, Volume: 19, Issue:10

    Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Bacterial Translocation; Co

2004
Oxazolone-induced colitis in BALB/C mice: a new method to evaluate the efficacy of therapeutic agents for ulcerative colitis.
    Journal of pharmacological sciences, 2004, Volume: 96, Issue:3

    Topics: Animals; Colitis; Colitis, Ulcerative; Dose-Response Relationship, Drug; Drug Evaluation, Preclinica

2004
Lymphtoxin beta receptor-Ig ameliorates TNBS-induced colitis via blocking LIGHT/HVEM signaling.
    Pharmacological research, 2005, Volume: 52, Issue:3

    Topics: Animals; CD4-Positive T-Lymphocytes; Colitis; Colon; Disease Models, Animal; Gene Expression Regulat

2005
Liposomal formulations of inflammatory bowel disease drugs: local versus systemic drug delivery in a rat model.
    Pharmaceutical research, 2005, Volume: 22, Issue:8

    Topics: Algorithms; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Transport, Active; Caco-2 C

2005
Up-regulation of anandamide levels as an endogenous mechanism and a pharmacological strategy to limit colon inflammation.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2006, Volume: 20, Issue:3

    Topics: Adult; Aged; Amidohydrolases; Animals; Arachidonic Acids; Benzenesulfonates; Colitis; Colitis, Ulcer

2006
A molecular mechanism for the anti-inflammatory effect of taurine-conjugated 5-aminosalicylic acid in inflamed colon.
    Molecular pharmacology, 2006, Volume: 69, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Chromatography, High Pressure Liquid; C

2006
Evaluation of 5-aminosalicyltaurine as a colon-specific prodrug of 5-aminosalicylic acid for treatment of experimental colitis.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2006, Volume: 28, Issue:1-2

    Topics: Aminosalicylic Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressur

2006
Effects of topical treatment of sodium butyrate and 5-aminosalicylic acid on expression of trefoil factor 3, interleukin 1beta, and nuclear factor kappaB in trinitrobenzene sulphonic acid induced colitis in rats.
    Postgraduate medical journal, 2006, Volume: 82, Issue:964

    Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Butyrates; Colitis; Inter

2006
Antioxidant therapy with N-acetylcysteine plus mesalamine accelerates mucosal healing in a rodent model of colitis.
    Digestive diseases and sciences, 2006, Volume: 51, Issue:4

    Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Biopsy, Needle; Coli

2006
Herpes simplex virus colitis in ulcerative colitis, simulating malignancy.
    Histopathology, 2006, Volume: 49, Issue:3

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colitis, Ulcerative; Diagnosis, Differentia

2006
[Lymphocitic colitis and celiac disease].
    Revista espanola de enfermedades digestivas, 2006, Volume: 98, Issue:6

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Celiac Disease; Colitis; Female; Humans; Mesalamine

2006
Azathioprine and mesalazine-induced effects on the mucosal flora in patients with IBD colitis.
    Inflammatory bowel diseases, 2007, Volume: 13, Issue:1

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Bacteria; Bacterial Adhesion; Colitis;

2007
Enhanced activity of a hydrogen sulphide-releasing derivative of mesalamine (ATB-429) in a mouse model of colitis.
    British journal of pharmacology, 2007, Volume: 150, Issue:8

    Topics: Animals; Anti-Inflammatory Agents; Chemokines; Colitis; Colon; Cytokines; Disease Models, Animal; Di

2007
Effects of Ginkgo biloba extract on inflammatory mediators (SOD, MDA, TNF-alpha, NF-kappaBp65, IL-6) in TNBS-induced colitis in rats.
    Mediators of inflammation, 2006, Volume: 2006, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Base Sequence; Colitis; Ginkgo bilob

2006
Colon-specific delivery of 5-aminosalicylic acid from chitosan-Ca-alginate microparticles.
    International journal of pharmaceutics, 2007, Sep-05, Volume: 342, Issue:1-2

    Topics: Alginates; Animals; Anti-Inflammatory Agents, Non-Steroidal; B-Lymphocytes; Body Weight; Calcium; Ca

2007
Protective effects of 2,3,5,4'-tetrahydroxystilbene-2-O-beta-d-glucoside, an active component of Polygonum multiflorum Thunb, on experimental colitis in mice.
    European journal of pharmacology, 2008, Jan-14, Volume: 578, Issue:2-3

    Topics: Acetic Acid; Acute Disease; Animals; Anti-Inflammatory Agents; Antioxidants; Chronic Disease; Coliti

2008
5-aminosalicylic acid given in the remission stage of colitis suppresses colitis-associated cancer in a mouse colitis model.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2007, Nov-01, Volume: 13, Issue:21

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Colitis; Colitis, Ulcerative; Disease

2007
Reduction of peroxisome proliferation-activated receptor gamma expression by gamma-irradiation as a mechanism contributing to inflammatory response in rat colon: modulation by the 5-aminosalicylic acid agonist.
    The Journal of pharmacology and experimental therapeutics, 2008, Volume: 324, Issue:3

    Topics: Animals; Colitis; Colon; Gamma Rays; Gene Expression Regulation; Inflammation; Male; Mesalamine; PPA

2008
The involvement of heme oxygenase-1 activity in the therapeutic actions of 5-aminosalicylic acid in rat colitis.
    European journal of pharmacology, 2008, Mar-10, Volume: 581, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Blotting, Western; Colitis; Disease

2008
The effect of propolisis and mesalazine on bacterial translocation in an experimental colitis model.
    Saudi medical journal, 2008, Volume: 29, Issue:3

    Topics: Animals; Anti-Infective Agents; Bacterial Translocation; Colitis; Mesalamine; Propolis; Terminology

2008
Natural history and long-term clinical behavior of segmental colitis associated with diverticulosis (SCAD syndrome).
    Digestive diseases and sciences, 2008, Volume: 53, Issue:9

    Topics: Abdominal Pain; Adult; Age Distribution; Aged; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Dia

2008
5-aminosalicylic acid inhibits colitis-associated colorectal dysplasias in the mouse model of azoxymethane/dextran sulfate sodium-induced colitis.
    Inflammatory bowel diseases, 2008, Volume: 14, Issue:10

    Topics: Animals; Azoxymethane; Colitis; Colorectal Neoplasms; Cyclooxygenase 2; Dextran Sulfate; Disease Mod

2008
5-aminosalicylic acid in serum and urine after administration by enema to patients with colitis.
    The Journal of pharmacy and pharmacology, 1983, Volume: 35, Issue:5

    Topics: Adult; Aged; Aminosalicylic Acids; Colitis; Enema; Female; Humans; Male; Mesalamine; Middle Aged

1983
The prophylactic effect of 5-aminosalicylic acid and salazosulphapyridine on degraded-carrageenan-induced colitis in guinea pigs.
    Scandinavian journal of gastroenterology, 1984, Volume: 19, Issue:3

    Topics: Aminosalicylic Acids; Animals; Carrageenan; Cecum; Colitis; Delayed-Action Preparations; Drug Evalua

1984
[Current therapeutic possibilities in chronic inflammatory intestinal diseases].
    Praxis, 1995, Jan-10, Volume: 84, Issue:2

    Topics: Aminosalicylic Acids; Chronic Disease; Colitis; Colitis, Ulcerative; Crohn Disease; Drug Therapy, Co

1995
Production of interleukin-1b and tumor necrosis factor--a by peripheral blood human mononuclear cells in active and inactive stages of ulcerative colitis.
    Zeitschrift fur Gastroenterologie, 1995, Volume: 33, Issue:1

    Topics: Administration, Oral; Adolescent; Adult; Aminosalicylic Acids; Anti-Inflammatory Agents, Non-Steroid

1995
Butyrate, mesalamine, and factor XIII in experimental colitis in the rat: effects on transglutaminase activity.
    Gastroenterology, 1994, Volume: 106, Issue:2

    Topics: Aminosalicylic Acids; Animals; Butyrates; Butyric Acid; Colitis; Factor XIII; Male; Mesalamine; Rats

1994
[Effect of mesalazine microgranules on experimental colitis].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1994, Volume: 104, Issue:4

    Topics: Aminosalicylic Acids; Animals; Carrageenan; Colitis; Delayed-Action Preparations; Guinea Pigs; Male;

1994
Mesalamine therapy in Reiter's syndrome.
    The Journal of rheumatology, 1994, Volume: 21, Issue:3

    Topics: Adult; Aminosalicylic Acids; Arthritis, Reactive; Colitis; Gastroenteritis; Humans; Ileitis; Male; M

1994
[Iatrogenic diffuse interstitial pneumonia linked to 5-aminosalicylate].
    Revue des maladies respiratoires, 1994, Volume: 11, Issue:3

    Topics: Aminosalicylic Acids; Colitis; Drug Therapy, Combination; Female; Gastrointestinal Hemorrhage; Human

1994
Effect of epidermal growth factor on experimental colitis in the rat.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 264, Issue:2

    Topics: Aminosalicylic Acids; Animals; Colitis; Colon; Disease Models, Animal; Eicosanoids; Epidermal Growth

1993
NPC 15669, an inhibitor of neutrophil recruitment, is efficacious in acetic acid-induced colitis in rats.
    Gastroenterology, 1993, Volume: 104, Issue:4

    Topics: Acetates; Acetic Acid; Aminosalicylic Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capil

1993
Distribution and anti-inflammatory effect of mesalazine on carrageenan-induced colitis in the rabbit.
    Clinical and experimental pharmacology & physiology, 1996, Volume: 23, Issue:4

    Topics: Aminosalicylic Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Carrageenan; Co

1996
Regional enteritis complicating malignant lymphoma.
    The Netherlands journal of medicine, 1996, Volume: 49, Issue:2

    Topics: Adult; Aminosalicylic Acids; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti

1996
Evaluating the antioxidant potential of new treatments for inflammatory bowel disease using a rat model of colitis.
    Gut, 1996, Volume: 39, Issue:3

    Topics: Acetic Acid; Aminosalicylic Acids; Animals; Antioxidants; Butylated Hydroxytoluene; Colitis; Colitis

1996
Intracolonic administration of zileuton, a selective 5-lipoxygenase inhibitor, accelerates healing in a rat model of chronic colitis.
    Gut, 1996, Volume: 38, Issue:6

    Topics: Aminosalicylic Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Colitis; Co

1996
Influence of topical rectal application of drugs on dextran sulfate-induced colitis in rats.
    Digestive diseases and sciences, 1997, Volume: 42, Issue:4

    Topics: Administration, Rectal; Aminosalicylic Acids; Anesthetics, Local; Animals; Anti-Inflammatory Agents;

1997
Diversion colitis: a cause of abdominal discomfort in spinal cord injury patients with colostomy.
    Archives of physical medicine and rehabilitation, 1997, Volume: 78, Issue:6

    Topics: Abdominal Pain; Aminosalicylic Acids; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colostomy; H

1997
Safety of topical 5-aminosalicylic acid in pregnancy.
    The American journal of gastroenterology, 1997, Volume: 92, Issue:12

    Topics: Abnormalities, Drug-Induced; Administration, Topical; Adult; Anti-Inflammatory Agents, Non-Steroidal

1997
[Collagenous colitis: presentation of 12 cases].
    Gastroenterologia y hepatologia, 1997, Volume: 20, Issue:10

    Topics: Adult; Aged; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Inflammato

1997
Oxazolone-induced colitis in rats: effects of budesonide, cyclosporin A, and 5-aminosalicylic acid.
    Scandinavian journal of gastroenterology, 1998, Volume: 33, Issue:2

    Topics: Animals; Budesonide; Colitis; Colon; Cyclosporine; Disease Models, Animal; Female; Intestinal Mucosa

1998
[Crohn's disease and pregnancy. A case report].
    Ginecologia y obstetricia de Mexico, 1998, Volume: 66

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Crohn Disease; Female; Humans; Infant, Newb

1998
Antioxidant effects of aminosalicylates and potential new drugs for inflammatory bowel disease: assessment in cell-free systems and inflamed human colorectal biopsies.
    Alimentary pharmacology & therapeutics, 1999, Volume: 13, Issue:3

    Topics: Adrenal Cortex Hormones; Adult; Aged; Aminosalicylic Acid; Aminosalicylic Acids; Anti-Infective Agen

1999
Anti-inflammatory activity of phycocyanin extract in acetic acid-induced colitis in rats.
    Pharmacological research, 1999, Volume: 39, Issue:1

    Topics: Acetic Acid; Animals; Anti-Inflammatory Agents; Colitis; Eukaryota; Male; Mesalamine; Microscopy, El

1999
[56-year-old patient with segmental florid colitis and colonic amyloidosis].
    Der Internist, 1999, Volume: 40, Issue:6

    Topics: Amyloidosis; Azathioprine; Colitis; Colonic Diseases; Colonoscopy; Crohn Disease; Diagnosis, Differe

1999
Enhanced anti-inflammatory effects of a nitric oxide-releasing derivative of mesalamine in rats.
    Gastroenterology, 1999, Volume: 117, Issue:3

    Topics: Aminosalicylic Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caspase 1; Cell Adhesion; Ce

1999
Lack of evidence for fibrosing colonopathy by 5-ASA in humans.
    Digestive diseases and sciences, 1999, Volume: 44, Issue:7

    Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Fibrosis; Humans; Intestinal

1999
L-glutamine enemas attenuate mucosal injury in experimental colitis.
    Diseases of the colon and rectum, 1999, Volume: 42, Issue:9

    Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Enema; Fatty Ac

1999
Beneficial effects of ropivacaine in rat experimental colitis.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 291, Issue:2

    Topics: Acetylcholine; Amides; Anesthetics, Local; Animals; Budesonide; Colitis; Ethanol; Gastrointestinal M

1999
Validation of a pharmacokinetic model of colon-specific drug delivery and the therapeutic effects of chitosan capsules containing 5-aminosalicylic acid on 2,4,6-trinitrobenzenesulphonic acid-induced colitis in rats.
    The Journal of pharmacy and pharmacology, 1999, Volume: 51, Issue:10

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsules; Chitin; Chitosan;

1999
Therapeutic role for bismuth compounds in TNBS-induced colitis in the rat.
    Digestive diseases and sciences, 2000, Volume: 45, Issue:3

    Topics: Animals; Anti-Ulcer Agents; Bismuth; Colitis; Female; Mesalamine; Organometallic Compounds; Rats; Ra

2000
Segmental colitis associated with diverticula: a prospective study. Gruppo di Studio per le Malattie Infiammatorie Intestinali (GSMII).
    The American journal of gastroenterology, 2000, Volume: 95, Issue:4

    Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colonoscopy; Diverticulit

2000
Short- and long-term follow-up of treatment for lymphocytic and collagenous colitis.
    Inflammatory bowel diseases, 2000, Volume: 6, Issue:2

    Topics: Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Collagen; Diarrhea

2000
Intestinal anti-inflammatory activity of UR-12746, a novel 5-ASA conjugate, on acute and chronic experimental colitis in the rat.
    British journal of pharmacology, 2000, Volume: 130, Issue:8

    Topics: Acute Disease; Aminosalicylic Acids; Animals; Anti-Inflammatory Agents; Aza Compounds; Chronic Disea

2000
Does the initial location of Crohn's disease have an influence on the time-to-relapse in patients under maintenance treatment with oral mesalamine?
    Journal of clinical gastroenterology, 2000, Volume: 31, Issue:2

    Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Crohn Disease; Female

2000
The effect of local attachment of cationized antioxidant enzymes on experimental colitis in the rat.
    Pharmaceutical research, 2000, Volume: 17, Issue:9

    Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Betamethas

2000
Treatment responses in collagenous colitis.
    The American journal of gastroenterology, 2001, Volume: 96, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; A

2001
Familial microscopic colitis.
    Canadian journal of gastroenterology = Journal canadien de gastroenterologie, 2001, Volume: 15, Issue:5

    Topics: Abdominal Pain; Adult; Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Colitis; Colonoscopy; Consti

2001
[Collagenous colitis. A study of 11 cases].
    Annales de medecine interne, 2001, Volume: 152, Issue:5

    Topics: Adult; Agammaglobulinemia; Aged; Aged, 80 and over; Anemia; Anti-Inflammatory Agents; Anti-Inflammat

2001
Gut inflammation targeted in UCLA HIV study.
    Women alive (Los Angeles, Calif.), 2000,Spring

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Colitis; HIV Infections; Humans;

2000
Clinical and histological predictors of response to medical therapy in collagenous colitis.
    The American journal of gastroenterology, 2002, Volume: 97, Issue:5

    Topics: Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; An

2002
Induction of colitis in rats by 2-2'-azobis(2-amidinopropane) dihydrochloride.
    Inflammation, 1992, Volume: 16, Issue:1

    Topics: Amidines; Aminosalicylic Acids; Animals; Benzopyrans; Colitis; Inflammation; Intestinal Mucosa; Lipi

1992
Effect of aminophenols (5-ASA and 4-ASA) on colonic interleukin-1 generation.
    Gut, 1992, Volume: 33, Issue:7

    Topics: Aminosalicylic Acid; Aminosalicylic Acids; Animals; Colitis; Colon; Disease Models, Animal; Humans;

1992
Sequential histologic evaluations in collagenous colitis. Correlations with disease behavior and sampling strategy.
    Digestive diseases and sciences, 1992, Volume: 37, Issue:12

    Topics: Adult; Aged; Aminosalicylic Acids; Colitis; Collagen; Colon; Female; Humans; Intestinal Mucosa; Male

1992
A case of diversion colitis treated with 5-aminosalicylic acid enemas.
    The American journal of gastroenterology, 1992, Volume: 87, Issue:5

    Topics: Aged; Aged, 80 and over; Aminosalicylic Acids; Colitis; Colostomy; Diverticulum, Colon; Enema; Femal

1992
Misoprostol therapy following trinitrobenzene sulfonic acid-induced colitis accelerates healing.
    Prostaglandins, leukotrienes, and essential fatty acids, 1992, Volume: 45, Issue:4

    Topics: Aminosalicylic Acids; Animals; Betamethasone; Colitis; Intestinal Absorption; Intestinal Mucosa; Mal

1992
Mesalazine release from coated tablets: effect of dietary fibre.
    British journal of clinical pharmacology, 1991, Volume: 32, Issue:2

    Topics: Adult; Aged; Aminosalicylic Acids; Colitis; Dietary Fiber; Feces; Female; Humans; Hydrogen-Ion Conce

1991
Azathioprine reduces extravasation and neutrophil trafficking in immune complex-mediated inflammation in the rat colon.
    Agents and actions, 1991, Volume: 34, Issue:1-2

    Topics: Aminosalicylic Acids; Animals; Antigen-Antibody Complex; Azathioprine; Colitis; Evans Blue; Male; Me

1991
Treatment of diversion colitis with 5-aminosalicylic acid enemas: comparison with betamethasone enemas.
    The American journal of gastroenterology, 1991, Volume: 86, Issue:10

    Topics: Aminosalicylic Acids; Betamethasone; Colitis; Enema; Female; Humans; Mesalamine; Middle Aged; Postop

1991
Participation of thromboxane and other eicosanoid synthesis in the course of experimental inflammatory colitis.
    Gastroenterology, 1990, Volume: 98, Issue:2

    Topics: 6-Ketoprostaglandin F1 alpha; Aminosalicylic Acids; Animals; Colitis; Dinoprostone; Indomethacin; Le

1990
Familial occurrence of collagenous colitis. A report of two families.
    Journal of clinical gastroenterology, 1990, Volume: 12, Issue:3

    Topics: Adult; Aged; Aminosalicylic Acids; Biopsy; Colitis; Collagen; Diarrhea; Female; Humans; Intestinal M

1990
Coeliac disease and collagenous colitis.
    Postgraduate medical journal, 1990, Volume: 66, Issue:773

    Topics: Adult; Aminosalicylic Acids; Celiac Disease; Colitis; Diarrhea; Humans; Jejunum; Male; Mesalamine; R

1990
Inhibition of leukotriene synthesis markedly accelerates healing in a rat model of inflammatory bowel disease.
    Gastroenterology, 1989, Volume: 96, Issue:1

    Topics: 6-Ketoprostaglandin F1 alpha; Aminosalicylic Acids; Animals; Chronic Disease; Colitis; Colon; Leukot

1989
Enemas for IBD maintenance therapy.
    Digestive diseases and sciences, 1989, Volume: 34, Issue:5

    Topics: Aminosalicylic Acids; Colitis; Enema; Humans; Mesalamine; Proctocolitis

1989
A possible mechanism of action of sulfasalazine and 5-aminosalicylic acid in inflammatory bowel diseases: interaction with oxygen free radicals.
    Gastroenterology, 1985, Volume: 89, Issue:5

    Topics: Aminosalicylic Acids; Animals; Chemical Phenomena; Chemistry; Colitis; Free Radicals; Humans; Indome

1985
Keratoconjunctivitis sicca and the treatment of canine colitis.
    The Veterinary record, 1986, Oct-04, Volume: 119, Issue:14

    Topics: Aminosalicylic Acids; Animals; Colitis; Dog Diseases; Dogs; Female; Keratoconjunctivitis; Keratoconj

1986
High-performance liquid chromatographic assay of 5-aminosalicylic acid and its acetylated metabolite in biological fluids using electrochemical detection.
    Journal of chromatography, 1988, Mar-04, Volume: 425, Issue:1

    Topics: Acetylation; Aminosalicylic Acids; Chromatography, High Pressure Liquid; Colitis; Electrochemistry;

1988