mesalamine has been researched along with Colitis in 223 studies
Mesalamine: An anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the active moiety of SULPHASALAZINE. (From Martindale, The Extra Pharmacopoeia, 30th ed)
mesalamine : A monohydroxybenzoic acid that is salicylic acid substituted by an amino group at the 5-position.
Colitis: Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.
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"Pericarditis should be considered in any patient complaining of chest pain and/or dyspnea who is taking a product that contains mesalamine or sulfasalazine." | 8.81 | Possible mesalamine-induced pericarditis: case report and literature review. ( Malinowski, JM; Waite, RA, 2002) |
"Mesalamine and/or cholestyramine may be effective for mild ICI diarrhea and colitis among patients with delayed symptom onset with lower colonic inflammatory burden." | 8.31 | Mesalamine and cholestyramine for immune checkpoint inhibitor-mediated diarrhea and colitis. ( Alasadi, M; Altan, M; Hollander, B; Jacob, JS; Khurana, S; Thomas, AS; Varatharajalu, K; Wang, J; Wang, Y; Zhao, D, 2023) |
"Mesalamine (MES), also known as 5-aminosalicylic acid, is effective in treating mild to moderate ulcerative colitis (UC)." | 8.12 | Mesalamine-Mediated Amelioration of Experimental Colitis in Piglets Involves Gut Microbiota Modulation and Intestinal Immune Cell Infiltration. ( Huang, Y; Liu, H; Wu, M; Xiao, H; Yang, G, 2022) |
"For local treatment of ulcerative colitis, a new azoreductase driven prodrug CDDO-AZO from bardoxolone methyl (CDDO-Me) and 5-aminosalicylate (5-ASA) was designed, synthesized and biologically evaluated." | 8.02 | Identification of a new azoreductase driven prodrug from bardoxolone methyl and 5-aminosalicylate for the treatment of colitis in mice. ( Gong, Y; Huang, ZJ; Mou, Y; Qiao, X; Wen, XD; Zhang, YH, 2021) |
"We examined whether metoclopramide (MCP), a modulator of dopamine and serotonin receptors, alleviated colitis and had synergistic effects when coadministered with 5-aminosalicylic acid (5-ASA) in an experimental model of colitis." | 7.91 | A colon-specific prodrug of metoclopramide ameliorates colitis in an experimental rat model. ( Jeong, S; Jung, Y; Kim, D; Kim, W; Yang, Y; Yoo, JW, 2019) |
" The present study was conducted to make comparison on therapeutic effectiveness of rectally administered FO and mesalazine in rats with trinitrobenzenesulfonic acid (TNBS)-induced colitis." | 7.91 | Therapeutic effectiveness of rectally administered fish oil and mesalazine in trinitrobenzenesulfonic acid-induced colitis. ( Altınay, S; Çelik, DS; Gökmen, ES; Küçük, SH; Şit, D; Yorulmaz, E; Yorulmaz, H; Zengi, O, 2019) |
"The present study developed novel zinc ion cross-linked alginate/N-succinyl-chitosan (NSC) blend microspheres (MS) for co-delivery of zinc and 5-aminosalicylic acid (5-ASA) for synergistic therapy of colitis." | 7.85 | Co-delivery of zinc and 5-aminosalicylic acid from alginate/N-succinyl-chitosan blend microspheres for synergistic therapy of colitis. ( Bai, X; Duan, H; Gao, C; Liu, M; Liu, Z; Lü, S; Qin, H; Wei, Y; Wu, X; Zhang, X, 2017) |
"Mesalamine (5-ASA) is one of the drugs indicated as first line therapy in ulcerative colitis for induction and maintenance of remission." | 7.83 | Discovery and preclinical development of a novel prodrug conjugate of mesalamine with eicosapentaenoic acid and caprylic acid for the treatment of inflammatory bowel diseases. ( Kandula, M; Palanichamy, S; Rampal, A; Sunil Kumar, KB, 2016) |
"Male mice imprinting control regions (ICR) were randomly divided into five groups: normal, TNBS-induced colitis, colitis treated with liquiritigenin at low dose (10 mg/kg) and high dose (20 mg/kg), or mesalazine (10 mg/kg)." | 7.81 | Amelioration of trinitrobenzene sulfonic acid-induced colitis in mice by liquiritigenin. ( Bae, H; Cha, JM; Jang, SE; Kim, DH; Kim, HJ; Lee, CH; Lim, SJ; Min, JK; Park, JW, 2015) |
" in normal gut mucosa and mucosa of animals with TNBS colitis, as well as the influence of Mesalamine (M." | 7.80 | Effect of mesalamine and prednisolone on TNBS experimental colitis, following various doses of orally administered iron. ( Agrogiannis, G; Douvi, G; Gikas, A; Papalois, AE; Patsouris, E; Triantafillidis, JK, 2014) |
" Here, we examined the effects of THSG on experimental mice with colitis induced by acetic acid and whether the underlying mechanisms were associated with the PPAR-γ and NF-κB pathways." | 7.77 | Beneficial effects of THSG on acetic acid-induced experimental colitis: involvement of upregulation of PPAR-γ and inhibition of the Nf-Κb inflammatory pathway. ( Chang, MJ; Wang, JL; Xiao, JH; Zeng, C, 2011) |
" In order to elucidate the pesticide effect and the mechanisms by which paeoniflorin exerts its effect of anti-inflammation and immunoregulation on oxazolone-induced colitic mice, disease activity index (DAI) and histological grading of colitis (HGC) were evaluated in animal model." | 7.76 | [Paeoniflorin increases beta-defensin expression and attenuates lesion in the colonic mucosa from mice with oxazolone-induced colitis]. ( Li, YS; Tao, YW; Wang, H; Zhang, JY; Zhang, ZQ; Zhou, Y, 2010) |
"The aim of the present studies was to examine mechanisms by which the rectally administered combination of N-acetylcysteine (NAC) plus mesalamine (5-ASA) affects inducers of inflammation to promote mucosal healing and reduce tissue inflammation in chemically (trinitrobenzene sulfonic acid, TNBS) induced colitis in rats." | 7.75 | Effects of N-acetylcysteine plus mesalamine on prostaglandin synthesis and nitric oxide generation in TNBS-induced colitis in rats. ( Ancha, HR; Harty, RF; Kurella, RR; Lightfoot, S; McKimmey, CC, 2009) |
"To investigate the effect of balsalazide on intestinal mucosal permeability of experimental colitis induced by dextran sulfate sodium(DSS) in a mouse model and its possible mechanism." | 7.75 | [Effect of balsalazide on intestinal mucosal permeability of dextran sulfate sodium-induced colitis in mice]. ( Hu, J; Liu, XC; Mei, Q; Xu, JM, 2009) |
"An experimental ulcerative colitis model was established by rectal injection of oxazolone into the colon of 40 Wistar rats randomly divided into four groups." | 7.75 | Therapeutic effects of Clostridium butyricum on experimental colitis induced by oxazolone in rats. ( Cui, YL; Ding, TT; Yang, X; Zhang, HQ; Zhang, HX; Zhang, JJ; Zhao, JS, 2009) |
"Previously, we reported that oral administration of taurine conjugated 5-aminosalicylic acid, a colon-specific prodrug of 5-aminosalicylic acid (5-ASA), is effective in ameliorating experimental colitis and taurine elicits an additive anti-inflammatory effect upon cotreatment with 5-ASA." | 7.75 | An anti-inflammatory mechanism of taurine conjugated 5-aminosalicylic acid against experimental colitis: taurine chloramine potentiates inhibitory effect of 5-aminosalicylic acid on IL-1beta-mediated NFkappaB activation. ( Choi, D; Han, J; Hong, S; Joo, K; Jung, Y; Kim, YM; Lee, Y, 2009) |
" The ameliorating effect of the azo conjugate and therapeutic efficacy of the carrier system was evaluated in trinitrobenzenesulfonic acid-induced experimental colitis model." | 7.74 | Colon-specific, mutual azo prodrug of 5-aminosalicylic acid with L-tryptophan: synthesis, kinetic studies and evaluation of its mitigating effect in trinitrobenzenesulfonic acid-induced colitis in rats. ( Bhatt, L; Dhaneshwar, SS; Gairola, N; Kandpal, M; Vadnerkar, G, 2007) |
"Previous experiments in rats with chemically induced colitis have shown that the antioxidant N-acetylcysteine plus mesalamine (5-ASA) exerted a significantly greater therapeutic effect in promoting mucosal healing when compared to either agent alone." | 7.74 | Luminal antioxidants enhance the effects of mesalamine in the treatment of chemically induced colitis in rats. ( Ancha, HR; Harty, RF; Kurella, RR; Lightfoot, S; McKimmey, CC, 2008) |
"We prospectively investigated colonoscopic biopsies from five groups of 20 subjects each: patients with ulcerative or indeterminate colitis treated with azathioprine (group 1), azathioprine and 5-ASA (group 2), 5-ASA (group 3), untreated IBD (group 4), and healthy controls." | 7.74 | Azathioprine and mesalazine-induced effects on the mucosal flora in patients with IBD colitis. ( Bengmark, S; Dörffel, Y; Lochs, H; Loening-Baucke, V; Swidsinski, A, 2007) |
"Mesalamine is the first-line therapy for colitis, but it lacks potency and is only effective for mild-to-moderate forms of this disease." | 7.74 | Enhanced activity of a hydrogen sulphide-releasing derivative of mesalamine (ATB-429) in a mouse model of colitis. ( Caliendo, G; Cirino, G; Distrutti, E; Fiorucci, S; Mencarelli, A; Orlandi, S; Santagada, V; Santucci, L; Wallace, JL, 2007) |
"The aims of this study were to examine the ability of the antioxidant N-acetylcysteine (NAC) and mesalamine (5-ASA) alone and in combination to affect TNBS-induced colitis in rat." | 7.73 | Antioxidant therapy with N-acetylcysteine plus mesalamine accelerates mucosal healing in a rodent model of colitis. ( Ancha, H; Harty, RF; Lightfoot, S; Siddiqui, A; Stewart, CA; Tedesco, D, 2006) |
"Colitis was induced using the iodoacetamide rat model, and rats were divided into different dietary groups of 6 rats each: 1, normal chow diet (control); 2, diet supplemented with iron; 3, iron supplementation and lycopene; 4, iron and Beta-carotene; 5, 5-ASA; 6, 5-ASA and lycopene; 7, 5-ASA and iron; 8, 5-ASA, iron, and lycopene." | 7.72 | 5-ASA and lycopene decrease the oxidative stress and inflammation induced by iron in rats with colitis. ( Bujanover, Y; Matas, Z; Nissenkorn, A; Reifen, R, 2004) |
" The purpose of the present study was to investigate the effects of mesalazine, and metronidazole-gentamicin combination, on bacterial translocation in an animal colitis model." | 7.72 | Effect of mesalazine, metronidazole and gentamicin on bacterial translocation in experimental colitis. ( Aydogan, H; Gulec, B; Kilinc, M; Kozak, O; Ozcan, A; Pekcan, M; Yigit, T; Yigitler, C, 2004) |
"The anti-inflammatory effect of c-phycocyanin extract was studied in acetic acid-induced colitis in rats." | 7.70 | Anti-inflammatory activity of phycocyanin extract in acetic acid-induced colitis in rats. ( Ancheta, O; Armesto, J; González, A; González, R; Merino, N; Remirez, D; Rodríguez, S; Romay, C, 1999) |
"The aim of this study was to investigate the role of 1-glutamine, short chain fatty acid, prednisolone, and mesalazine (5-aminosalicylic acid) enemas on mucosal damage and inflammation in experimental colitis." | 7.70 | L-glutamine enemas attenuate mucosal injury in experimental colitis. ( Bayer, A; Gür, ES; Kaya, E; Ozgüç, H; Tokyay, R, 1999) |
"Ropivacaine, a new, long-acting local anesthetic agent, has been shown to have beneficial effects in the treatment of ulcerative colitis." | 7.70 | Beneficial effects of ropivacaine in rat experimental colitis. ( Hellström, PM; Ljung, T; Martinsson, T; Rubio, C, 1999) |
"Rats with induced colitis were treated with sodium butyrate, mesalamine, sodium butyrate plus mesalamine, or saline enemas." | 7.69 | Butyrate, mesalamine, and factor XIII in experimental colitis in the rat: effects on transglutaminase activity. ( Cosenza, V; D'Argenio, G; D'Armiento, FP; De Ritis, F; Delle Cave, M; Gatto, A; Mazzacca, G; Sorrentini, I, 1994) |
"The effect of intracolonic administration of zileuton (a 5-lipoxygenase inhibitor) on colonic damage and eicosanoid local release was assessed in a rat model of colitis." | 7.69 | Intracolonic administration of zileuton, a selective 5-lipoxygenase inhibitor, accelerates healing in a rat model of chronic colitis. ( Bartolí, R; Bertrán, X; Castellá, E; Esteve, M; Fernández-Bañares, F; Gassull, MA; Mañé, J; Ojanguren, I, 1996) |
"The effect of epidermal growth factor on the rate of healing was examined in a rat model of colitis." | 7.68 | Effect of epidermal growth factor on experimental colitis in the rat. ( Bass, P; Luck, MS, 1993) |
"The efficacy of the leukocyte recruitment inhibitor, N-[9H-2,7-dimethylfluoren-9-ylmethoxy)carbonyl]-L-leucine (NPC 15669) was compared with drugs used to treat inflammatory bowel diseases in a rat model, acetic acid-induced colitis." | 7.68 | NPC 15669, an inhibitor of neutrophil recruitment, is efficacious in acetic acid-induced colitis in rats. ( Burch, RM; Lowe, VC; Muhlhauser, RO; Noronha-Blob, L, 1993) |
"Mesalamine was effective for treatment of chronic diarrhea and moderate nonspecific colitis in HIV patients." | 6.72 | Double-blind pilot study of mesalamine vs. placebo for treatment of chronic diarrhea and nonspecific colitis in immunocompetent HIV patients. ( Fernández-Carbia, A; Marxuach-Cuétara, AM; Ríos-Bedoya, CF; Rodríguez-Orengo, JF; Rodríguez-Torres, M; Salgado-Mercado, R, 2006) |
"Colitis was induced in mice by intracolonic (i." | 5.51 | Evaluation of the effect of liposomes loaded with chlorogenic acid in treatment of 2,4,6-trinitrobenzenesulfonic acid-induced murine colitis. ( Chen, C; Czapor-Irzabek, H; Fichna, J; Gorniak, A; Karolewicz, B; Krajewska, JB; Owczarek, A; Pietruszka, P; Tomczyk, D, 2019) |
"Colitis was induced in female swiss mice by adding DSS 3% to the drinking water." | 5.48 | Antioxidant and anti-inflammatory effect of plumieride in dextran sulfate sodium-induced colitis in mice. ( Andrade, SF; Boeing, T; Bonomini, TJ; da Silva, LM; de Souza, P; Lucinda, RM; Malheiros, A; Mariano, LNB; Somensi, LB, 2018) |
"Colitis was induced by administration of 1 mL AA (4%) via a polyethylene catheter intrarectally." | 5.39 | Comparative protective effect of hawthorn berry hydroalcoholic extract, atorvastatin, and mesalamine on experimentally induced colitis in rats. ( Hobbenaghi, R; Malekinejad, H; Moshtaghion, SM; Shafie-Irannejad, V; Tabatabaie, SH, 2013) |
"Colitis was induced by intrarectal administration of OXA solution (7." | 5.32 | Oxazolone-induced colitis in BALB/C mice: a new method to evaluate the efficacy of therapeutic agents for ulcerative colitis. ( Hatakeyama, S; Kojima, R; Kuroda, S; Nakamaru, K; Ohkishi, T, 2004) |
"On day 1 colitis was induced with 50 mg TNBS/50% ethanol in female Sprague-Dawley rats, while controls received a saline enema." | 5.31 | Therapeutic role for bismuth compounds in TNBS-induced colitis in the rat. ( Cleary, CE; Malatjalian, DA; Peterson, TC; Shaw, AM; Veldhuyzen van Zanten, SJ, 2000) |
"A pharmacokinetic model of colon-specific drug delivery developed in a previous study has been validated by use of 5-aminosalicylic acid (5-ASA) as a model anti-inflammatory drug." | 5.30 | Validation of a pharmacokinetic model of colon-specific drug delivery and the therapeutic effects of chitosan capsules containing 5-aminosalicylic acid on 2,4,6-trinitrobenzenesulphonic acid-induced colitis in rats. ( Fujita, T; Muranishi, S; Odoriba, T; Okabe, S; Terabe, A; Tozaki, H; Yamamoto, A, 1999) |
"Pericarditis should be considered in any patient complaining of chest pain and/or dyspnea who is taking a product that contains mesalamine or sulfasalazine." | 4.81 | Possible mesalamine-induced pericarditis: case report and literature review. ( Malinowski, JM; Waite, RA, 2002) |
"Mesalamine and/or cholestyramine may be effective for mild ICI diarrhea and colitis among patients with delayed symptom onset with lower colonic inflammatory burden." | 4.31 | Mesalamine and cholestyramine for immune checkpoint inhibitor-mediated diarrhea and colitis. ( Alasadi, M; Altan, M; Hollander, B; Jacob, JS; Khurana, S; Thomas, AS; Varatharajalu, K; Wang, J; Wang, Y; Zhao, D, 2023) |
"Mesalamine (MES), also known as 5-aminosalicylic acid, is effective in treating mild to moderate ulcerative colitis (UC)." | 4.12 | Mesalamine-Mediated Amelioration of Experimental Colitis in Piglets Involves Gut Microbiota Modulation and Intestinal Immune Cell Infiltration. ( Huang, Y; Liu, H; Wu, M; Xiao, H; Yang, G, 2022) |
"For local treatment of ulcerative colitis, a new azoreductase driven prodrug CDDO-AZO from bardoxolone methyl (CDDO-Me) and 5-aminosalicylate (5-ASA) was designed, synthesized and biologically evaluated." | 4.02 | Identification of a new azoreductase driven prodrug from bardoxolone methyl and 5-aminosalicylate for the treatment of colitis in mice. ( Gong, Y; Huang, ZJ; Mou, Y; Qiao, X; Wen, XD; Zhang, YH, 2021) |
" The agents tested were: alpha-lactoalbumin (ALAC), a whey protein rich in tryptophan, effective in some animal models of epilepsy and on colon/intestine inflammation, valproic acid (VPA), an effective antiepileptic drug in this seizure model, mesalazine (MSZ) an effective aminosalicylate anti-inflammatory treatment against ulcerative colitis and sodium butyrate (NaB), a short chain fatty acid (SCFA) normally produced in the intestine by gut microbiota, important in maintaining gut health and reducing gut inflammation and oxidative stress." | 3.91 | Intestinal inflammation increases convulsant activity and reduces antiepileptic drug efficacy in a mouse model of epilepsy. ( Avagliano, C; Calignano, A; Citraro, R; Constanti, A; De Caro, C; De Sarro, G; di Cesare Mannelli, L; Ghelardini, C; Leo, A; Mainardi, P; Nesci, V; Russo, E; Striano, P, 2019) |
"We examined whether metoclopramide (MCP), a modulator of dopamine and serotonin receptors, alleviated colitis and had synergistic effects when coadministered with 5-aminosalicylic acid (5-ASA) in an experimental model of colitis." | 3.91 | A colon-specific prodrug of metoclopramide ameliorates colitis in an experimental rat model. ( Jeong, S; Jung, Y; Kim, D; Kim, W; Yang, Y; Yoo, JW, 2019) |
" The present study was conducted to make comparison on therapeutic effectiveness of rectally administered FO and mesalazine in rats with trinitrobenzenesulfonic acid (TNBS)-induced colitis." | 3.91 | Therapeutic effectiveness of rectally administered fish oil and mesalazine in trinitrobenzenesulfonic acid-induced colitis. ( Altınay, S; Çelik, DS; Gökmen, ES; Küçük, SH; Şit, D; Yorulmaz, E; Yorulmaz, H; Zengi, O, 2019) |
" Our aim was to examine local and remote consequences of ASA-Tris administration in 2-,4-,6-trinitrobenzene-sulfonic acid (TNBS)-induced colitis as compared to ASA or mesalamine (5-aminosalicylate) treatment." | 3.88 | Acetylsalicylic acid-tris-hydroxymethyl-aminomethane reduces colon mucosal damage without causing gastric side effects in a rat model of colitis. ( Boros, M; Érces, D; Ghyczy, M; Hartmann, P; Jász, DK; Lajkó, N; Molnár, R; Szűcs, S; Tóth, G; Ugocsai, M; Varga, G, 2018) |
" The strong inhibitory activity of compound 55 against an in vivo colitis model was confirmed by its dose-dependent inhibitory activity in a rat model of 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis, demonstrating compound 55 as a new potential candidate for the development of therapeutics against IBD." | 3.85 | Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease. ( Banskota, S; Bist, G; Gurung, P; Kadayat, TM; Kim, JA; Lee, ES; Shrestha, A; Thapa Magar, TB, 2017) |
"), with that of 5-aminosalicylic acid (5-ASA), a first-line drug in IBD, in a 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis rat model." | 3.85 | Comparison of anti-inflammatory activities of an anthocyanin-rich fraction from Portuguese blueberries (Vaccinium corymbosum L.) and 5-aminosalicylic acid in a TNBS-induced colitis rat model. ( Almeida, LM; Dinis, TC; Figueiredo, I; Freitas, V; Pereira, R; Pereira, SR, 2017) |
"The present study developed novel zinc ion cross-linked alginate/N-succinyl-chitosan (NSC) blend microspheres (MS) for co-delivery of zinc and 5-aminosalicylic acid (5-ASA) for synergistic therapy of colitis." | 3.85 | Co-delivery of zinc and 5-aminosalicylic acid from alginate/N-succinyl-chitosan blend microspheres for synergistic therapy of colitis. ( Bai, X; Duan, H; Gao, C; Liu, M; Liu, Z; Lü, S; Qin, H; Wei, Y; Wu, X; Zhang, X, 2017) |
"This study represents the first evidence that combination therapy with balsalazide and parthenolide could be a new regimen for colorectal cancer treatment." | 3.85 | Combined Parthenolide and Balsalazide Have Enhanced Antitumor Efficacy Through Blockade of NF-κB Activation. ( Jeong, HJ; Kim, EM; Kim, IH; Kim, SH; Kim, SL; Kim, SW; Kim, YN; Lee, SO; Lee, ST; Liu, YC; Park, YR; Seo, SY, 2017) |
" Oral gavage of 5-ASA-azo-PA alleviated 2,4,6-trinitrobenzenesulfonic acid-induced rat colitis." | 3.83 | 5-Aminosalicylic Acid Azo-Linked to Procainamide Acts as an Anticolitic Mutual Prodrug via Additive Inhibition of Nuclear Factor kappaB. ( Jeong, S; Jung, Y; Kim, W; Lee, S; Nam, J, 2016) |
"In this work, thiolated chitosan/alginate composite microparticulates (CMPs) coated by Eudragit S-100 were developed for colon-specific delivery of 5-aminosalicylic acid (5-ASA) and curcumin (CUR), and the use of it as a multi drug delivery system for the treatment of colitis." | 3.83 | Mucoadhesive microparticulates based on polysaccharide for target dual drug delivery of 5-aminosalicylic acid and curcumin to inflamed colon. ( Bai, X; Duan, H; Gao, C; Liu, M; Lü, S; Qin, H; Wei, Y; Wu, X, 2016) |
"Mesalamine (5-ASA) is one of the drugs indicated as first line therapy in ulcerative colitis for induction and maintenance of remission." | 3.83 | Discovery and preclinical development of a novel prodrug conjugate of mesalamine with eicosapentaenoic acid and caprylic acid for the treatment of inflammatory bowel diseases. ( Kandula, M; Palanichamy, S; Rampal, A; Sunil Kumar, KB, 2016) |
"Male mice imprinting control regions (ICR) were randomly divided into five groups: normal, TNBS-induced colitis, colitis treated with liquiritigenin at low dose (10 mg/kg) and high dose (20 mg/kg), or mesalazine (10 mg/kg)." | 3.81 | Amelioration of trinitrobenzene sulfonic acid-induced colitis in mice by liquiritigenin. ( Bae, H; Cha, JM; Jang, SE; Kim, DH; Kim, HJ; Lee, CH; Lim, SJ; Min, JK; Park, JW, 2015) |
" Colonic specificity of 5-ASA tablets (prepared using guar gum and pectin as polymers) was evaluated in vitro using simulated fluids mimicking in vivo environment as well as in vivo method using chemically (2,4,6-trinitrobenzenesulfonic acid and acetic acid)-induced colitis rat model." | 3.81 | In Vivo Evaluation of 5-ASA Colon-Specific Tablets Using Experimental-Induced Colitis Rat Animal Model. ( Bajaj, AN; Deshpande, SG; Nikam, VS; Sawarkar, SP, 2015) |
"To investigate the therapeutic and immunoregulatory effects of 1,25-dihydroxyvitamin D (1,25(OH)D3) on 2,4,6-trinitrobenzenesulfonic acid (TNBS) -induced colitis in rats." | 3.81 | 1,25-hydroxyvitamin D relieves colitis in rats via down-regulation of toll-like receptor 9 expression. ( Dai, ZH; Lv, H; Qian, JM; Tan, B; Wang, O; Yang, H, 2015) |
" in normal gut mucosa and mucosa of animals with TNBS colitis, as well as the influence of Mesalamine (M." | 3.80 | Effect of mesalamine and prednisolone on TNBS experimental colitis, following various doses of orally administered iron. ( Agrogiannis, G; Douvi, G; Gikas, A; Papalois, AE; Patsouris, E; Triantafillidis, JK, 2014) |
" The effects of RNP(O) were determined in mice with dextran sodium sulfate (DSS)-induced colitis and compared with those of low-molecular-weight drugs (4-hydroxyl-2,2,6,6-tetramethylpiperidine-1-oxyl [TEMPOL] or mesalamine)." | 3.78 | An orally administered redox nanoparticle that accumulates in the colonic mucosa and reduces colitis in mice. ( Matsui, H; Nagasaki, Y; Tomita, T; Vong, LB; Yoshitomi, T, 2012) |
" Subsequently, its protective effect in indomethacin and iodoacetamide induced colitis in rats (45, 90, 180, 270 mg/kg) and acetic acid induced colitis in mice (65, 130, 250, 500 mg/kg) was assessed." | 3.77 | Protective effect of aqueous extract of Bombax malabaricum DC on experimental models of inflammatory bowel disease in rats and mice. ( Jagtap, AG; Niphadkar, PV; Phadke, AS, 2011) |
" Here, we examined the effects of THSG on experimental mice with colitis induced by acetic acid and whether the underlying mechanisms were associated with the PPAR-γ and NF-κB pathways." | 3.77 | Beneficial effects of THSG on acetic acid-induced experimental colitis: involvement of upregulation of PPAR-γ and inhibition of the Nf-Κb inflammatory pathway. ( Chang, MJ; Wang, JL; Xiao, JH; Zeng, C, 2011) |
" The in vivo antineoplastic effect of 2-methoxy-5-amino-N-hydroxybenzamide (2-14) was evaluated in a syngenic, CT26-derived xenograft mouse model of CRC and in the azoxymethane/dextran sulfate sodium-induced mouse model of colitis-associated CRC." | 3.76 | Inhibition of colon carcinogenesis by 2-methoxy-5-amino-N-hydroxybenzamide, a novel derivative of mesalamine. ( Caruso, R; Fantini, MC; Fina, D; Macdonald, TT; Monteleone, G; Pallone, F; Palmieri, G; Pellegrini, R; Sarra, M; Stolfi, C, 2010) |
" In order to elucidate the pesticide effect and the mechanisms by which paeoniflorin exerts its effect of anti-inflammation and immunoregulation on oxazolone-induced colitic mice, disease activity index (DAI) and histological grading of colitis (HGC) were evaluated in animal model." | 3.76 | [Paeoniflorin increases beta-defensin expression and attenuates lesion in the colonic mucosa from mice with oxazolone-induced colitis]. ( Li, YS; Tao, YW; Wang, H; Zhang, JY; Zhang, ZQ; Zhou, Y, 2010) |
" The prodrugs exhibited comparable ameliorating effect as that of sulfasalazine on trinitrobenzenesulfonic acid-induced experimental colitis in rats with a better safety profile." | 3.75 | Synthesis, kinetic studies and pharmacological evaluation of mutual azo prodrugs of 5-aminosalicylic acid for colon-specific drug delivery in inflammatory bowel disease. ( Bhatt, L; Dhaneshwar, SS; Gairola, N; Kadam, SS; Kandpal, M; Rathi, B; Vadnerkar, G, 2009) |
"The aim of the present studies was to examine mechanisms by which the rectally administered combination of N-acetylcysteine (NAC) plus mesalamine (5-ASA) affects inducers of inflammation to promote mucosal healing and reduce tissue inflammation in chemically (trinitrobenzene sulfonic acid, TNBS) induced colitis in rats." | 3.75 | Effects of N-acetylcysteine plus mesalamine on prostaglandin synthesis and nitric oxide generation in TNBS-induced colitis in rats. ( Ancha, HR; Harty, RF; Kurella, RR; Lightfoot, S; McKimmey, CC, 2009) |
"To investigate the effect of balsalazide on intestinal mucosal permeability of experimental colitis induced by dextran sulfate sodium(DSS) in a mouse model and its possible mechanism." | 3.75 | [Effect of balsalazide on intestinal mucosal permeability of dextran sulfate sodium-induced colitis in mice]. ( Hu, J; Liu, XC; Mei, Q; Xu, JM, 2009) |
"An experimental ulcerative colitis model was established by rectal injection of oxazolone into the colon of 40 Wistar rats randomly divided into four groups." | 3.75 | Therapeutic effects of Clostridium butyricum on experimental colitis induced by oxazolone in rats. ( Cui, YL; Ding, TT; Yang, X; Zhang, HQ; Zhang, HX; Zhang, JJ; Zhao, JS, 2009) |
"Previously, we reported that oral administration of taurine conjugated 5-aminosalicylic acid, a colon-specific prodrug of 5-aminosalicylic acid (5-ASA), is effective in ameliorating experimental colitis and taurine elicits an additive anti-inflammatory effect upon cotreatment with 5-ASA." | 3.75 | An anti-inflammatory mechanism of taurine conjugated 5-aminosalicylic acid against experimental colitis: taurine chloramine potentiates inhibitory effect of 5-aminosalicylic acid on IL-1beta-mediated NFkappaB activation. ( Choi, D; Han, J; Hong, S; Joo, K; Jung, Y; Kim, YM; Lee, Y, 2009) |
" The ameliorating effect of the azo conjugate and therapeutic efficacy of the carrier system was evaluated in trinitrobenzenesulfonic acid-induced experimental colitis model." | 3.74 | Colon-specific, mutual azo prodrug of 5-aminosalicylic acid with L-tryptophan: synthesis, kinetic studies and evaluation of its mitigating effect in trinitrobenzenesulfonic acid-induced colitis in rats. ( Bhatt, L; Dhaneshwar, SS; Gairola, N; Kandpal, M; Vadnerkar, G, 2007) |
"Previous experiments in rats with chemically induced colitis have shown that the antioxidant N-acetylcysteine plus mesalamine (5-ASA) exerted a significantly greater therapeutic effect in promoting mucosal healing when compared to either agent alone." | 3.74 | Luminal antioxidants enhance the effects of mesalamine in the treatment of chemically induced colitis in rats. ( Ancha, HR; Harty, RF; Kurella, RR; Lightfoot, S; McKimmey, CC, 2008) |
"We prospectively investigated colonoscopic biopsies from five groups of 20 subjects each: patients with ulcerative or indeterminate colitis treated with azathioprine (group 1), azathioprine and 5-ASA (group 2), 5-ASA (group 3), untreated IBD (group 4), and healthy controls." | 3.74 | Azathioprine and mesalazine-induced effects on the mucosal flora in patients with IBD colitis. ( Bengmark, S; Dörffel, Y; Lochs, H; Loening-Baucke, V; Swidsinski, A, 2007) |
"Mesalamine is the first-line therapy for colitis, but it lacks potency and is only effective for mild-to-moderate forms of this disease." | 3.74 | Enhanced activity of a hydrogen sulphide-releasing derivative of mesalamine (ATB-429) in a mouse model of colitis. ( Caliendo, G; Cirino, G; Distrutti, E; Fiorucci, S; Mencarelli, A; Orlandi, S; Santagada, V; Santucci, L; Wallace, JL, 2007) |
" In this study, we examined the effects of 2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside (THSG), an active component extracted from Polygonum multiflorum Thunb, on acetic acid-induced acute colitis and mitomycin C-induced chronic colitis." | 3.74 | Protective effects of 2,3,5,4'-tetrahydroxystilbene-2-O-beta-d-glucoside, an active component of Polygonum multiflorum Thunb, on experimental colitis in mice. ( Chen, S; Han, T; Wang, J; Wang, X; Zhao, L, 2008) |
"The aims of this study were to examine the ability of the antioxidant N-acetylcysteine (NAC) and mesalamine (5-ASA) alone and in combination to affect TNBS-induced colitis in rat." | 3.73 | Antioxidant therapy with N-acetylcysteine plus mesalamine accelerates mucosal healing in a rodent model of colitis. ( Ancha, H; Harty, RF; Lightfoot, S; Siddiqui, A; Stewart, CA; Tedesco, D, 2006) |
"Colitis was induced using the iodoacetamide rat model, and rats were divided into different dietary groups of 6 rats each: 1, normal chow diet (control); 2, diet supplemented with iron; 3, iron supplementation and lycopene; 4, iron and Beta-carotene; 5, 5-ASA; 6, 5-ASA and lycopene; 7, 5-ASA and iron; 8, 5-ASA, iron, and lycopene." | 3.72 | 5-ASA and lycopene decrease the oxidative stress and inflammation induced by iron in rats with colitis. ( Bujanover, Y; Matas, Z; Nissenkorn, A; Reifen, R, 2004) |
" The purpose of the present study was to investigate the effects of mesalazine, and metronidazole-gentamicin combination, on bacterial translocation in an animal colitis model." | 3.72 | Effect of mesalazine, metronidazole and gentamicin on bacterial translocation in experimental colitis. ( Aydogan, H; Gulec, B; Kilinc, M; Kozak, O; Ozcan, A; Pekcan, M; Yigit, T; Yigitler, C, 2004) |
"The anti-inflammatory effect of c-phycocyanin extract was studied in acetic acid-induced colitis in rats." | 3.70 | Anti-inflammatory activity of phycocyanin extract in acetic acid-induced colitis in rats. ( Ancheta, O; Armesto, J; González, A; González, R; Merino, N; Remirez, D; Rodríguez, S; Romay, C, 1999) |
"Effects of an NO-releasing derivative of mesalamine (NCX-456; NO-mesalamine) were compared with those of mesalamine itself and 2 other NO donors in a rat model of colitis." | 3.70 | Enhanced anti-inflammatory effects of a nitric oxide-releasing derivative of mesalamine in rats. ( Asfaha, S; Chapman, K; Del Soldato, P; Fiorucci, S; McKnight, W; Morelli, A; Muscará, MN; Vergnolle, N; Wallace, JL, 1999) |
"The aim of this study was to investigate the role of 1-glutamine, short chain fatty acid, prednisolone, and mesalazine (5-aminosalicylic acid) enemas on mucosal damage and inflammation in experimental colitis." | 3.70 | L-glutamine enemas attenuate mucosal injury in experimental colitis. ( Bayer, A; Gür, ES; Kaya, E; Ozgüç, H; Tokyay, R, 1999) |
"Ropivacaine, a new, long-acting local anesthetic agent, has been shown to have beneficial effects in the treatment of ulcerative colitis." | 3.70 | Beneficial effects of ropivacaine in rat experimental colitis. ( Hellström, PM; Ljung, T; Martinsson, T; Rubio, C, 1999) |
"Rats with induced colitis were treated with sodium butyrate, mesalamine, sodium butyrate plus mesalamine, or saline enemas." | 3.69 | Butyrate, mesalamine, and factor XIII in experimental colitis in the rat: effects on transglutaminase activity. ( Cosenza, V; D'Argenio, G; D'Armiento, FP; De Ritis, F; Delle Cave, M; Gatto, A; Mazzacca, G; Sorrentini, I, 1994) |
"Amplified chemiluminescence was used to measure reactive oxygen species production by colonic biopsy specimens from rats with acetic acid induced colitis and to assess the in vitro effect of conventional antioxidants, standard therapies and proposed novel therapies for inflammatory bowel disease." | 3.69 | Evaluating the antioxidant potential of new treatments for inflammatory bowel disease using a rat model of colitis. ( Blades, S; Blake, DR; Chander, CL; Claxson, AW; Coumbe, A; Millar, AD; Morris, CJ; Panetta, J; Rampton, DS, 1996) |
"The effect of intracolonic administration of zileuton (a 5-lipoxygenase inhibitor) on colonic damage and eicosanoid local release was assessed in a rat model of colitis." | 3.69 | Intracolonic administration of zileuton, a selective 5-lipoxygenase inhibitor, accelerates healing in a rat model of chronic colitis. ( Bartolí, R; Bertrán, X; Castellá, E; Esteve, M; Fernández-Bañares, F; Gassull, MA; Mañé, J; Ojanguren, I, 1996) |
"A rat model of colitis [dextran sulfate (DSS)] was used to study the permeation of Evans blue (EB) from the lumen into the wall of proximal and distal colonic loops after exposure to the dye for 2 hr." | 3.69 | Influence of topical rectal application of drugs on dextran sulfate-induced colitis in rats. ( Ahlman, H; Björck, S; Dahlström, A; Jennische, E, 1997) |
"The effect of epidermal growth factor on the rate of healing was examined in a rat model of colitis." | 3.68 | Effect of epidermal growth factor on experimental colitis in the rat. ( Bass, P; Luck, MS, 1993) |
"The efficacy of the leukocyte recruitment inhibitor, N-[9H-2,7-dimethylfluoren-9-ylmethoxy)carbonyl]-L-leucine (NPC 15669) was compared with drugs used to treat inflammatory bowel diseases in a rat model, acetic acid-induced colitis." | 3.68 | NPC 15669, an inhibitor of neutrophil recruitment, is efficacious in acetic acid-induced colitis in rats. ( Burch, RM; Lowe, VC; Muhlhauser, RO; Noronha-Blob, L, 1993) |
"Mesalamine was effective for treatment of chronic diarrhea and moderate nonspecific colitis in HIV patients." | 2.72 | Double-blind pilot study of mesalamine vs. placebo for treatment of chronic diarrhea and nonspecific colitis in immunocompetent HIV patients. ( Fernández-Carbia, A; Marxuach-Cuétara, AM; Ríos-Bedoya, CF; Rodríguez-Orengo, JF; Rodríguez-Torres, M; Salgado-Mercado, R, 2006) |
"In patients with Crohn's colitis or ileocolitis, or in those with ileitis, no statistically significant differences were noted with respect to the relapse rates between the 5-ASA and the placebo treatment groups." | 2.68 | Mesalazine (Mesasal/Claversal) 1.5 g b.d. vs. placebo in the maintenance of remission of patients with Crohn's disease. ( Adler, M; Bailey, RJ; Rachmilewitz, D; Thomson, AB; Vatn, M; Wilson-Lynch, KA; Wright, JP, 1995) |
"Microscopic colitis is a recently recognized cause of diarrhoea, predominantly affecting older women, but its response to treatment is poorly documented." | 2.67 | Response to treatment of microscopic colitis. ( Fasoli, R; Jewell, DP, 1994) |
"The genetics of isolated colonic Crohn's disease place it approximately midway between Crohn's disease with small intestinal involvement and UC, making a case for considering it as a separate condition." | 2.55 | Recent advances in clinical practice: a systematic review of isolated colonic Crohn's disease: the third IBD? ( Ekbom, A; Rhodes, JM; Subramanian, S, 2017) |
"Individuals with ulcerative colitis face an increased risk of developing colorectal cancer and would benefit from early chemopreventive intervention." | 2.49 | Differential response of flat and polypoid colitis-associated colorectal neoplasias to chemopreventive agents and heterocyclic amines. ( Chang, WC; Clapper, ML; Cooper, HS; Zenser, TV, 2013) |
"Segmental colitis associated with colonic diverticulosis is a new and emerging entity." | 2.48 | Segmental colitis associated with diverticulosis: systematic evaluation of 486 cases with meta-analysis. ( Hoda, KK; Mann, NS, 2012) |
"Conventional therapies for ulcerative colitis and Crohn's disease (CD) include aminosalicylates, corticosteroids, thiopurines, methotrexate, and anti-tumor necrosis factor agents." | 2.47 | Conventional medical management of inflammatory bowel disease. ( Burger, D; Travis, S, 2011) |
"Eosinophilic colitis is an idiopathic inflammation of the alimentary canal and is characterized by infiltration of the intestinal wall by eosinophils, massive submucosal edema, and peripheral eosinophilia." | 2.47 | Eosinophilic-Crohn overlap colitis and review of the literature. ( Katsanos, KH; Lambri, E; Tsianos, EV; Zinovieva, E, 2011) |
"In familial and sporadic colorectal cancer, aspirin, other nonsteroidal anti-inflammatory drugs and cyclo-oxygenase-2 inhibitors have been tested for their ability to reduce polyp and cancer development in clinical studies." | 2.42 | Review article: the chemoprevention of colorectal carcinoma. ( Gasche, C, 2004) |
"Whereas the incidence of ulcerative colitis has remained stable at around 8-9/10(5), the incidence of Crohn's disease has increased from below 1 to more than 5/10(5) per year during the last three decades." | 2.41 | [Therapeutic principles for chronic inflammatory bowel disease]. ( Binder, V; Munkholm, P, 2001) |
"Mesalazine is an aminosalicillic derivative considered as a safe alternative to the relative frequency (5-55%) of adverse effects observed with sulfasalazine." | 2.40 | [Non-immunoallergic hepatotoxicity due to mesalazine]. ( Barroso, N; Gavilán, F; Guil, A; Larrauri, J; Leo, E; Reina, FR; Tirado, C; Zafra, C, 1999) |
"Because intestinal inflammation affects the gut microbiota and 5-ASA can change the severity of inflammation, assessing the impact of inflammation and 5-ASA on the gut microbiota is not feasible in a clinical study of patients with UC." | 1.91 | 5-Aminosalicylic acid alters the gut microbiota and altered microbiota transmitted vertically to offspring have protective effects against colitis. ( Akimoto, Y; Hibi, N; Hibi, T; Hisamatsu, T; Kobayashi, T; Kuronuma, S; Lee, STM; Matsuura, M; Miyoshi, J; Nishinarita, Y; Oguri, N; Takeuchi, O; Wada, H, 2023) |
"Ulcerative colitis is a relapsing and remitting disease that may be associated with flares." | 1.91 | Factors contributing to flares of ulcerative colitis in North India- a case-control study. ( Dutta, U; Jearth, V; Mahajan, G; Patil, AN; Rana, VS; Saroch, A; Sekar, A; Sharma, V; Singh, AK; Singh, H, 2023) |
"Phycocyanobilin was obtained by solvothermal alcoholysis of phycocyanin and characterized by spectroscopy and mass spectrometry methods." | 1.72 | Phycocyanin ameliorates mouse colitis ( Guo, W; Li, S; Qian, Y; Wu, H; Zeng, M; Zhu, S, 2022) |
"However, the PPS-treated colitis group showed higher gene expression of IL-35 EBI3 subunit by 1." | 1.72 | Pentosan Polysulfate Sodium augments the therapeutic effect of 5-Aminosalicylic Acid in DSS colitis model; the role of IL-35 expression. ( AbdElfattah, AA; Ashour, RH; El-Kady, RA; Elmasry, A; Hazem, NM, 2022) |
"Diversion colitis and ulcerative colitis (UC) can be caused by different mechanisms; however, several case reports have described the development of typical UC following diversion colitis." | 1.72 | Progression of ulcerative colitis following diversion colitis. ( Araki, K; Inayama, Y; Kimura, H; Kumagai, J; Kunisaki, R; Maeda, S; Matsune, Y; Yaguchi, K, 2022) |
"Infliximab is used for ulcerative colitis but could also be effective against severe DC." | 1.62 | Novel application of infliximab for diversion colitis. ( Kido, M; Okajima, H; Tamura, R; Yasui, Y, 2021) |
"Colitis was induced in mice using 2,4,6-trinitrobenzene-sulfonic acid (TNBS), and mice were subsequently treated with either a PD-1 inhibitor or 5-amino-salicylic acid (ASA) as a positive control." | 1.62 | Inhibition of PD-1 Protects against TNBS-Induced Colitis via Alteration of Enteric Microbiota. ( Du, YL; He, J; Huang, HL; Li, YF; Nie, YQ; Xu, HM; Xu, J; Zhao, C; Zhou, YJ; Zhou, YL, 2021) |
"Colitis was induced in mice by intracolonic (i." | 1.51 | Evaluation of the effect of liposomes loaded with chlorogenic acid in treatment of 2,4,6-trinitrobenzenesulfonic acid-induced murine colitis. ( Chen, C; Czapor-Irzabek, H; Fichna, J; Gorniak, A; Karolewicz, B; Krajewska, JB; Owczarek, A; Pietruszka, P; Tomczyk, D, 2019) |
"Colitis was diagnosed by histological analysis and the inflammatory reaction by validated score." | 1.51 | Enemas with mesalazine increase the tissue contents of mucins in the colonic mucosa devoid of fecal stream. ( Campos, FG; Goto, EFK; Kanno, DT; Martinez, CAR; Matijascic, GM; Meneses, EC; Pereira, JA, 2019) |
"Colitis was induced in female swiss mice by adding DSS 3% to the drinking water." | 1.48 | Antioxidant and anti-inflammatory effect of plumieride in dextran sulfate sodium-induced colitis in mice. ( Andrade, SF; Boeing, T; Bonomini, TJ; da Silva, LM; de Souza, P; Lucinda, RM; Malheiros, A; Mariano, LNB; Somensi, LB, 2018) |
"At day 3 after the beginning of the treatment, colitis was induced by intrarectal administration of trinitrobenzene sulfonic acid (TNBS)." | 1.42 | In vivo efficacy of microbiota-sensitive coatings for colon targeting: a promising tool for IBD therapy. ( Beghyn, T; Deprez, B; Desreumaux, P; Dubreuil, L; Dubuquoy, L; Flament, MP; Guerin-Deremaux, L; Karrout, Y; Moussa, E; Neut, C; Piveteau, C; Siepmann, F; Siepmann, J; Wils, D, 2015) |
"As seen in active ulcerative colitis (UC), the formation of crypt abscesses was observed in the biopsy." | 1.42 | A case of diverticular colitis with lesions resembling ulcerative colitis and correlation of tumor necrosis factor-alpha staining with clinical manifestations. ( Inui, K; Katano, Y; Kobayashi, T; Kosaka, T; Torii, Y; Wakabayasi, T; Yoshino, J, 2015) |
"Eosinophilic colitis is a rare mostly self-limiting disease affecting middle-aged adults." | 1.40 | Eosinophilic colitis is a sporadic self-limited disease of middle-aged people: a population-based study. ( Alfadda, AA; Shaffer, EA; Storr, MA; Urbanski, SJ, 2014) |
"Colitis was induced by administration of 1 mL AA (4%) via a polyethylene catheter intrarectally." | 1.39 | Comparative protective effect of hawthorn berry hydroalcoholic extract, atorvastatin, and mesalamine on experimentally induced colitis in rats. ( Hobbenaghi, R; Malekinejad, H; Moshtaghion, SM; Shafie-Irannejad, V; Tabatabaie, SH, 2013) |
"Colitis was induced by intrarectal injection of TNBS while control rats received the vehicle." | 1.39 | Adjunct therapy of n-3 fatty acids to 5-ASA ameliorates inflammatory score and decreases NF-κB in rats with TNBS-induced colitis. ( Aziz, M; Bole-Feysot, C; Charpentier, C; Déchelotte, P; Guérin, C; Marion-Letellier, R; Mbodji, K; Querec, C; Savoye, G, 2013) |
"Colitis was evaluated by means of the length of the colon, white blood cell count (WBC), tissue myeloperoxidase (MPO) activity, and histological inflammation scores." | 1.35 | Oral administration of mesalazine protects against mucosal injury and permeation in dextran sulfate sodium-induced colitis in rats. ( Aoyagi, K; Hayashi, Y; Morita, I; Sakisaka, S; Yamamoto, C, 2009) |
"The risk of colorectal cancer is increased in patients with inflammatory bowel diseases, especially those with ulcerative colitis (UC)." | 1.34 | 5-aminosalicylic acid given in the remission stage of colitis suppresses colitis-associated cancer in a mouse colitis model. ( Endo, H; Fujisawa, T; Fujita, K; Ikeda, I; Inamori, M; Kubota, K; Nagashima, Y; Nakagama, H; Nakajima, A; Nozaki, Y; Saito, S; Takahashi, H; Tomimoto, A; Wada, K; Yoneda, M; Yonemitsu, K, 2007) |
"Distal colitis was induced in male Wistar rats by colonic administration of TNBS and colonically treated with NaB, 5-ASA, combination of NaB and 5-ASA, and normal saline for 14 consecutive days." | 1.33 | Effects of topical treatment of sodium butyrate and 5-aminosalicylic acid on expression of trefoil factor 3, interleukin 1beta, and nuclear factor kappaB in trinitrobenzene sulphonic acid induced colitis in rats. ( Li, J; Song, M; Xia, B, 2006) |
"Colitis was induced by intrarectal administration of OXA solution (7." | 1.32 | Oxazolone-induced colitis in BALB/C mice: a new method to evaluate the efficacy of therapeutic agents for ulcerative colitis. ( Hatakeyama, S; Kojima, R; Kuroda, S; Nakamaru, K; Ohkishi, T, 2004) |
"On day 1 colitis was induced with 50 mg TNBS/50% ethanol in female Sprague-Dawley rats, while controls received a saline enema." | 1.31 | Therapeutic role for bismuth compounds in TNBS-induced colitis in the rat. ( Cleary, CE; Malatjalian, DA; Peterson, TC; Shaw, AM; Veldhuyzen van Zanten, SJ, 2000) |
"Relapse was defined by CD Activity Index > or = 150, CD Endoscopic Index of Severity > or =4, and by an abnormal increase of C-reactive protein, white blood cell count, and erythrocyte sedimentation rate; moreover, if it was confirmed by x-ray and/or endoscopy." | 1.31 | Does the initial location of Crohn's disease have an influence on the time-to-relapse in patients under maintenance treatment with oral mesalamine? ( Bertoni, M; Bresci, G; Capria, A; Masolino, P; Parisi, G; Scatena, F, 2000) |
"To investigate the possibility of local treatment of colitis with the adhesive antioxidant enzymes catalase and superoxide dismutase (SOD)." | 1.31 | The effect of local attachment of cationized antioxidant enzymes on experimental colitis in the rat. ( Bass, P; Blau, S; Kohen, R; Rubinstein, A, 2000) |
"Collagenous colitis is a treatable condition in most patients." | 1.31 | Treatment responses in collagenous colitis. ( Fiedler, LM; George, J; Harpaz, N; Janowitz, HD; Kornbluth, AA; Sachar, DB, 2001) |
"Diversion colitis is thought to result from nutritional deficiencies secondary to fecal diversion." | 1.30 | Diversion colitis: a cause of abdominal discomfort in spinal cord injury patients with colostomy. ( Chuang, TY; Francisco, GE; Lai, JM; Strayer, JR, 1997) |
"Will pregnancy affect the disease? 4." | 1.30 | [Crohn's disease and pregnancy. A case report]. ( Gudiño Molina, FJ; Jinich Brook, H; Montiel-Jarquin, A; Rodríguez Torres, LF, 1998) |
"A pharmacokinetic model of colon-specific drug delivery developed in a previous study has been validated by use of 5-aminosalicylic acid (5-ASA) as a model anti-inflammatory drug." | 1.30 | Validation of a pharmacokinetic model of colon-specific drug delivery and the therapeutic effects of chitosan capsules containing 5-aminosalicylic acid on 2,4,6-trinitrobenzenesulphonic acid-induced colitis in rats. ( Fujita, T; Muranishi, S; Odoriba, T; Okabe, S; Terabe, A; Tozaki, H; Yamamoto, A, 1999) |
"In Crohn's disease as well as in ulcerative colitis steroids are of major importance in the treatment of active disease." | 1.29 | [Current therapeutic possibilities in chronic inflammatory intestinal diseases]. ( Schölmerich, J, 1995) |
"A patient with chronic Reiter's syndrome (RS) refractory to nonsteroidal antiinflammatory therapy was prescribed mesalamine (Pentasa) therapy for a 4-month trial." | 1.29 | Mesalamine therapy in Reiter's syndrome. ( Inman, RD; McKibbon, C; Thomson, GT, 1994) |
"Azathioprine (AZ) has been used in the treatment of refractory inflammatory bowel disease." | 1.28 | Azathioprine reduces extravasation and neutrophil trafficking in immune complex-mediated inflammation in the rat colon. ( Anania, T; Clearfield, HR; Murthy, SN, 1991) |
"Treatment with prednisone or 5-aminosalicylic acid reduced TXB2 levels in the chronic stage of the inflammatory disease and improved the morphological damage as assessed macroscopically and histologically." | 1.28 | Participation of thromboxane and other eicosanoid synthesis in the course of experimental inflammatory colitis. ( Guarner, F; Malagelada, JR; Rodriguez, R; Salas, A; Vilaseca, J, 1990) |
"Collagenous colitis is a rare condition characterized clinically by chronic diarrhea and histologically by a thickened subepithelial collagenous band in colonic biopsies in an endoscopically normal colon." | 1.28 | Familial occurrence of collagenous colitis. A report of two families. ( Blok, P; Dekker, W; Lam, HG; Meuwissen, SG; Seldenrijk, CA; Stel, HV; van Tilburg, AJ, 1990) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 12 (5.38) | 18.7374 |
1990's | 43 (19.28) | 18.2507 |
2000's | 64 (28.70) | 29.6817 |
2010's | 70 (31.39) | 24.3611 |
2020's | 34 (15.25) | 2.80 |
Authors | Studies |
---|---|
Rousseaux, C | 2 |
Lefebvre, B | 1 |
Dubuquoy, L | 2 |
Lefebvre, P | 1 |
Romano, O | 1 |
Auwerx, J | 1 |
Metzger, D | 1 |
Wahli, W | 1 |
Desvergne, B | 1 |
Naccari, GC | 1 |
Chavatte, P | 3 |
Farce, A | 1 |
Bulois, P | 1 |
Cortot, A | 1 |
Colombel, JF | 2 |
Desreumaux, P | 4 |
Dhaneshwar, SS | 4 |
Kandpal, M | 3 |
Vadnerkar, G | 4 |
Rathi, B | 2 |
Kadam, SS | 2 |
Gairola, N | 2 |
Bhatt, L | 2 |
Chail, M | 1 |
Patil, M | 1 |
Naqvi, S | 1 |
Andrzejak, V | 2 |
Muccioli, GG | 2 |
Body-Malapel, M | 2 |
El Bakali, J | 2 |
Djouina, M | 2 |
Renault, N | 1 |
Lambert, DM | 2 |
Millet, R | 2 |
Kim, J | 1 |
Kang, S | 1 |
Hong, S | 2 |
Yum, S | 1 |
Kim, YM | 3 |
Jung, Y | 9 |
Gilleron, P | 1 |
Mansouri, R | 1 |
Barczyk, A | 1 |
Klupsch, F | 1 |
Lipka, E | 1 |
Furman, C | 1 |
Xi, M | 1 |
Ge, J | 1 |
Wang, X | 3 |
Sun, C | 1 |
Liu, T | 1 |
Fang, L | 1 |
Xiao, Q | 1 |
Yin, D | 1 |
Kadayat, TM | 2 |
Banskota, S | 2 |
Gurung, P | 2 |
Bist, G | 2 |
Thapa Magar, TB | 1 |
Shrestha, A | 2 |
Kim, JA | 3 |
Lee, ES | 2 |
Magar, TBT | 1 |
Tian, X | 1 |
Gao, J | 2 |
Liu, M | 3 |
Lei, Y | 1 |
Wang, F | 1 |
Chen, J | 4 |
Chu, P | 1 |
Long, F | 1 |
Liang, M | 1 |
Long, X | 1 |
Chu, H | 1 |
Liu, C | 1 |
Li, X | 1 |
Sun, Q | 1 |
Li, G | 1 |
Yang, Y | 6 |
Karmacharya, U | 1 |
Regmi, SC | 1 |
Awasthi, BP | 1 |
Chaudhary, P | 1 |
Kim, YE | 1 |
Lee, IH | 1 |
Nam, TG | 1 |
Jeong, BS | 1 |
Kido, M | 1 |
Tamura, R | 1 |
Yasui, Y | 1 |
Okajima, H | 1 |
Tian, W | 1 |
Xu, X | 1 |
Zheng, Z | 1 |
Liu, S | 1 |
Ying, J | 1 |
Zhang, X | 2 |
Guo, W | 2 |
Zeng, M | 2 |
Zhu, S | 1 |
Li, S | 3 |
Qian, Y | 1 |
Wu, H | 2 |
Ashour, RH | 1 |
Hazem, NM | 1 |
AbdElfattah, AA | 1 |
El-Kady, RA | 1 |
Elmasry, A | 1 |
Huang, Y | 1 |
Wu, M | 1 |
Xiao, H | 1 |
Liu, H | 2 |
Yang, G | 1 |
Huang, L | 1 |
Zheng, J | 1 |
Sun, G | 1 |
Yang, H | 2 |
Sun, X | 1 |
Yao, X | 1 |
Lin, A | 1 |
Hollander, B | 1 |
Khurana, S | 1 |
Jacob, JS | 1 |
Altan, M | 1 |
Wang, J | 2 |
Zhao, D | 1 |
Varatharajalu, K | 1 |
Alasadi, M | 1 |
Thomas, AS | 1 |
Wang, Y | 1 |
Huang, S | 2 |
Xie, X | 1 |
Su, Y | 1 |
Pan, Z | 1 |
Li, Y | 3 |
Liang, J | 2 |
Zhang, M | 1 |
Pan, S | 1 |
Xu, B | 1 |
Li, L | 1 |
Luo, X | 1 |
Zhou, L | 3 |
Yaguchi, K | 1 |
Matsune, Y | 1 |
Kunisaki, R | 1 |
Araki, K | 1 |
Kimura, H | 1 |
Inayama, Y | 1 |
Kumagai, J | 1 |
Maeda, S | 1 |
Yuan, N | 1 |
Chai, Y | 1 |
Song, Y | 1 |
Zhao, Y | 1 |
Cheng, C | 1 |
Hu, J | 3 |
Ji, Y | 1 |
Lian, Z | 1 |
Au, R | 1 |
Xu, F | 1 |
Li, W | 1 |
Shen, H | 1 |
Zhu, L | 1 |
Tange, K | 1 |
Yagi, S | 1 |
Takeshita, E | 1 |
Abe, M | 1 |
Yamamoto, Y | 1 |
Tomida, H | 1 |
Kawamura, T | 1 |
Hanayama, M | 1 |
Matsuura, B | 1 |
Ikeda, Y | 1 |
Hiasa, Y | 1 |
Chen, K | 1 |
Shang, S | 1 |
Yu, S | 1 |
Cui, L | 1 |
He, N | 1 |
Liu, YH | 2 |
Rong, ZL | 2 |
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Romay, C | 1 |
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Vergnolle, N | 1 |
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Del Soldato, P | 2 |
Morelli, A | 1 |
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Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Prevalence of Segmental Colitis Associated With Colic Diverticulosis (SCAD): an Observational Study[NCT04279821] | 50 participants (Anticipated) | Observational | 2020-02-01 | Recruiting | |||
A Prospective, Randomized, Double-blind, Parallel, Placebo-controlled, Multi-center Study to Investigate the Efficacy and Safety of Apomivir® in Relieving Influenza Symptoms[NCT01677689] | Phase 2 | 196 participants (Anticipated) | Interventional | 2018-09-01 | Not yet recruiting | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
22 reviews available for mesalamine and Colitis
Article | Year |
---|---|
Antioxidant and anti-inflammatory protective effects of yellowtail (
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Arginine; Caco-2 Cells; Claudin-4; Colitis; Cycloox | 2022 |
Effects of 5-aminosalicylates or thiopurines on the progression of low-grade dysplasia in patients with inflammatory bowel disease: a systematic review and meta-analysis.
Topics: Colitis; Colorectal Neoplasms; Humans; Inflammatory Bowel Diseases; Mesalamine; Risk Factors | 2021 |
New Insights of Oral Colonic Drug Delivery Systems for Inflammatory Bowel Disease Therapy.
Topics: Administration, Oral; Aminosalicylic Acids; Animals; Colitis; Colon; Drug Delivery Systems; Drug Lib | 2020 |
Risk Factors for Vitamin D Deficiency in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.
Topics: Biological Products; Colitis; Crohn Disease; Humans; Inflammatory Bowel Diseases; Male; Mesalamine; | 2021 |
Differential response of flat and polypoid colitis-associated colorectal neoplasias to chemopreventive agents and heterocyclic amines.
Topics: Amines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Carcinogens; Cell Proliferation | 2013 |
Segmental colitis associated with diverticulosis: systematic evaluation of 486 cases with meta-analysis.
Topics: Abdominal Pain; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Biopsy; Colitis; Colonosco | 2012 |
Actual Usage and Quality of Experimental Colitis Models in Preclinical Efficacy Testing: A Scoping Review.
Topics: Adrenal Cortex Hormones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomedical Research; Coli | 2016 |
Recent advances in clinical practice: a systematic review of isolated colonic Crohn's disease: the third IBD?
Topics: Adalimumab; Adrenal Cortex Hormones; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; | 2017 |
Conventional medical management of inflammatory bowel disease.
Topics: Adrenal Cortex Hormones; Algorithms; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroid | 2011 |
Eosinophilic-Crohn overlap colitis and review of the literature.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Crohn Disease; Eosinophilia; Humans; Male; M | 2011 |
Aminosalicylates.
Topics: Aminosalicylic Acids; Anti-Inflammatory Agents; Colitis; Diverticulitis, Colonic; Humans; Mesalamine | 2012 |
[A case of acute phase ulcerative colitis like colitis developed by the interferon-beta therapy for chronic hepatitis C].
Topics: Acute-Phase Reaction; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colitis, Ulcerative; Colonos | 2003 |
Nitric oxide-releasing mesalamine: potential utility for treatment of inflammatory bowel disease.
Topics: Aminosalicylic Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Colitis; Cytokine | 2003 |
Collagenous colitis evolving into ulcerative colitis: a case report and review of the literature.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colitis, Ulcerative; Colonoscopy; Diagnosis, Diffe | 2003 |
Review article: the chemoprevention of colorectal carcinoma.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Aspirin; Chemoprevention; Chromosoma | 2004 |
Collagenous and lymphocytic colitis: subject review and therapeutic alternatives.
Topics: Algorithms; Aminosalicylic Acids; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Colitis; | 1995 |
[The local therapy of distal colitis and ulcerative proctitis].
Topics: Administration, Rectal; Aminosalicylic Acids; Colitis; Colitis, Ulcerative; Cromolyn Sodium; Fatty A | 1993 |
[Non-immunoallergic hepatotoxicity due to mesalazine].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Colitis; Diagnosis, | 1999 |
[Therapeutic principles for chronic inflammatory bowel disease].
Topics: Adjuvants, Immunologic; Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Colectomy; Colitis; C | 2001 |
Possible mesalamine-induced pericarditis: case report and literature review.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Chest Pain; Colitis; Female; Humans; Mesalamine; Per | 2002 |
Oral 5-aminosalicyclic acid in children with colonic chronic inflammatory bowel disease: clinical and pharmacokinetic experience.
Topics: Administration, Oral; Adolescent; Aminosalicylic Acids; Chronic Disease; Colitis; Drug Tolerance; Fe | 1989 |
[Management of refractory and fulminating colitis].
Topics: Aminosalicylic Acids; Colitis; Crohn Disease; Glucocorticoids; Humans; Mesalamine; Severity of Illne | 1987 |
8 trials available for mesalamine and Colitis
Article | Year |
---|---|
Use of the 'nutriceutical', bovine colostrum, for the treatment of distal colitis: results from an initial study.
Topics: Adolescent; Adult; Aged; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cattle; Colitis; Colostru | 2002 |
Double-blind pilot study of mesalamine vs. placebo for treatment of chronic diarrhea and nonspecific colitis in immunocompetent HIV patients.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Chronic Disease; Colitis; Colonoscopy; Diarr | 2006 |
Response to treatment of microscopic colitis.
Topics: Aminosalicylic Acids; Colitis; Colon; Diarrhea; Drug Therapy, Combination; Eosinophils; Female; Foll | 1994 |
Mesalazine (Mesasal/Claversal) 1.5 g b.d. vs. placebo in the maintenance of remission of patients with Crohn's disease.
Topics: Adult; Aged; Aminosalicylic Acids; Anti-Inflammatory Agents, Non-Steroidal; Canada; Colitis; Crohn D | 1995 |
Mesalazine (5-aminosalicylic acid) suppositories in the treatment of ulcerative proctitis or distal proctosigmoiditis. A randomized controlled trial.
Topics: Adult; Aminosalicylic Acids; Colitis; Double-Blind Method; Female; Humans; Male; Mesalamine; Multice | 1990 |
[Effects of corticoids, 5-aminosalycilic acid and sucralfate on the potential difference of the rectum in inflammatory colitis in man].
Topics: Action Potentials; Administration, Rectal; Aminosalicylic Acids; Colitis; Female; Humans; Hydrocorti | 1989 |
Proctocolitis unresponsive to conventional therapy. Response to 5-aminosalicylic acid enemas.
Topics: Adult; Aminosalicylic Acids; Clinical Trials as Topic; Colitis; Enema; Female; Follow-Up Studies; Hu | 1987 |
5-Aminosalicylic acid enema in the treatment of distal ulcerative colitis, proctosigmoiditis, and proctitis.
Topics: Adult; Aminosalicylic Acids; Colitis; Colitis, Ulcerative; Enema; Female; Humans; Male; Mesalamine; | 1987 |
193 other studies available for mesalamine and Colitis
Article | Year |
---|---|
Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma.
Topics: 3T3-L1 Cells; Animals; Anti-Inflammatory Agents; Colitis; Colon; Gene Expression Regulation; HT29 Ce | 2005 |
Synthesis, kinetic studies and pharmacological evaluation of mutual azo prodrug of 5-aminosalicylic acid for colon-specific drug delivery in inflammatory bowel disease.
Topics: Aminosalicylic Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colon; Female; Male | 2007 |
Colon-specific, mutual azo prodrug of 5-aminosalicylic acid with L-tryptophan: synthesis, kinetic studies and evaluation of its mitigating effect in trinitrobenzenesulfonic acid-induced colitis in rats.
Topics: Animals; Azo Compounds; Body Weight; Colitis; Kinetics; Mesalamine; Molecular Structure; Organ Size; | 2007 |
Colon-specific mutual amide prodrugs of 4-aminosalicylic acid for their mitigating effect on experimental colitis in rats.
Topics: Aminosalicylic Acids; Animals; Colitis; Colon; Drug Delivery Systems; Drug Stability; Drug-Related S | 2009 |
Synthesis, kinetic studies and pharmacological evaluation of mutual azo prodrugs of 5-aminosalicylic acid for colon-specific drug delivery in inflammatory bowel disease.
Topics: Aminosalicylic Acids; Animals; Arthritis; Colitis; Colon; Female; Inflammatory Bowel Diseases; Male; | 2009 |
New FAAH inhibitors based on 3-carboxamido-5-aryl-isoxazole scaffold that protect against experimental colitis.
Topics: Amidohydrolases; Animals; Colitis; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Hum | 2011 |
Structure-activity relationship of salicylic acid derivatives on inhibition of TNF-α dependent NFκB activity: Implication on anti-inflammatory effect of N-(5-chlorosalicyloyl)phenethylamine against experimental colitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Survival; Chemokine CXCL2; Colitis; HCT116 Ce | 2012 |
4-Oxo-1,4-dihydropyridines as selective CB₂ cannabinoid receptor ligands. Part 2: discovery of new agonists endowed with protective effect against experimental colitis.
Topics: Adamantane; Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding, Competitive; Blood Proteins; | 2012 |
Development of hydroxy-based sphingosine kinase inhibitors and anti-inflammation in dextran sodium sulfate induced colitis in mice.
Topics: Animals; Colitis; Dextran Sulfate; Enzyme Inhibitors; HCT116 Cells; Humans; Mice; Phosphotransferase | 2016 |
Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease.
Topics: Animals; Benzofurans; Colitis; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Discov | 2017 |
Synthesis and biological evaluation of pyridine-linked indanone derivatives: Potential agents for inflammatory bowel disease.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Adhesion; Colitis; Dise | 2018 |
Small-Molecule Antagonist Targeting Exportin-1 via Rational Structure-Based Discovery.
Topics: Amino Acid Sequence; Animals; Colitis; Dose-Response Relationship, Drug; Drug Delivery Systems; Drug | 2020 |
Synthesis and activity of N-(5-hydroxy-3,4,6-trimethylpyridin-2-yl)acetamide analogues as anticolitis agents via dual inhibition of TNF-α- and IL-6-induced cell adhesions.
Topics: Acetamides; Animals; Cell Adhesion; Colitis; Dose-Response Relationship, Drug; Interleukin-6; Molecu | 2021 |
Novel application of infliximab for diversion colitis.
Topics: Adult; Colectomy; Colitis; Colitis, Ulcerative; Humans; Infliximab; Male; Mesalamine; Treatment Outc | 2021 |
Effects of jianguiqre decotion combined with mesalazine enteriic-coated tablets and bifid triple capsule dissolving at testines on the efficacy, TCM scores and inflammatory factors of patients with severe chronic colitis.
Topics: Colitis; Colitis, Ulcerative; Humans; Mesalamine; Tablets | 2022 |
Phycocyanin ameliorates mouse colitis
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Caco-2 Cells; Colitis; Epithelial Ce | 2022 |
Pentosan Polysulfate Sodium augments the therapeutic effect of 5-Aminosalicylic Acid in DSS colitis model; the role of IL-35 expression.
Topics: Animals; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Animal; Female; Inter | 2022 |
Mesalamine-Mediated Amelioration of Experimental Colitis in Piglets Involves Gut Microbiota Modulation and Intestinal Immune Cell Infiltration.
Topics: Animals; Colitis; Colitis, Ulcerative; Dextran Sulfate; Gastrointestinal Microbiome; Mesalamine; Swi | 2022 |
5-Aminosalicylic acid ameliorates dextran sulfate sodium-induced colitis in mice by modulating gut microbiota and bile acid metabolism.
Topics: Animals; Bile Acids and Salts; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Gastrointest | 2022 |
Mesalamine and cholestyramine for immune checkpoint inhibitor-mediated diarrhea and colitis.
Topics: Adult; Cholestyramine Resin; Colitis; Diarrhea; Female; Humans; Immune Checkpoint Inhibitors; Immuno | 2023 |
Dahuang Mudan decoction repairs intestinal barrier in chronic colitic mice by regulating the function of ILC3.
Topics: Animals; Body Weight; Caco-2 Cells; Claudin-1; Colitis; Colitis, Ulcerative; Culture Media, Conditio | 2022 |
Progression of ulcerative colitis following diversion colitis.
Topics: Colitis; Colitis, Ulcerative; Colonoscopy; Diverticulum, Colon; Humans; Male; Mesalamine; Middle Age | 2022 |
Qing-Chang-Hua-Shi granule ameliorates DSS-induced colitis by activating NLRP6 signaling and regulating Th17/Treg balance.
Topics: Animals; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Drugs, Chinese Herbal; Inflammasomes; | 2022 |
Oral administration of human carbonic anhydrase I suppresses colitis in a murine inflammatory bowel disease model.
Topics: Administration, Oral; Animals; Carbonic Anhydrase I; Colitis; Disease Models, Animal; Humans; Inflam | 2022 |
Identification and exploration of pharmacological pyroptosis-related biomarkers of ulcerative colitis.
Topics: Animals; Biomarkers, Pharmacological; Colitis; Colitis, Ulcerative; Dextran Sulfate; Mesalamine; Mic | 2022 |
[Mechanism of Shenling Baizhu Powder on treatment of ulcerative colitis based on NLRP3 inflammatory].
Topics: Animals; Caspase 1; Colitis; Colitis, Ulcerative; Colon; Cytokines; Dextran Sulfate; Disease Models, | 2022 |
[Mechanism of Shenling Baizhu Powder on treatment of ulcerative colitis based on NLRP3 inflammatory].
Topics: Animals; Caspase 1; Colitis; Colitis, Ulcerative; Colon; Cytokines; Dextran Sulfate; Disease Models, | 2022 |
[Mechanism of Shenling Baizhu Powder on treatment of ulcerative colitis based on NLRP3 inflammatory].
Topics: Animals; Caspase 1; Colitis; Colitis, Ulcerative; Colon; Cytokines; Dextran Sulfate; Disease Models, | 2022 |
[Mechanism of Shenling Baizhu Powder on treatment of ulcerative colitis based on NLRP3 inflammatory].
Topics: Animals; Caspase 1; Colitis; Colitis, Ulcerative; Colon; Cytokines; Dextran Sulfate; Disease Models, | 2022 |
Protective effect of 7-hydroxyl-1-methylindole-3-acetonitrile on the intestinal mucosal damage response to inflammation in mice with DSS-induced colitis.
Topics: Animals; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Animal; Drinking Wate | 2023 |
Icosapent ethyl alleviates acetic acid-induced ulcerative colitis via modulation of SIRT1 signaling pathway in rats.
Topics: Acetic Acid; Animals; Caspase 3; Colitis; Colitis, Ulcerative; Collagen; Colon; Eicosapentaenoic Aci | 2023 |
Efficacy of active ingredients in Qingdai on ulcerative colitis: a network pharmacology-based evaluation.
Topics: Animals; Colitis; Colitis, Ulcerative; Colon; Disease Models, Animal; Glycogen Synthase Kinase 3; Me | 2023 |
Topics: Animals; Colitis; Drug Delivery Systems; Mesalamine; Mice; Plants; Zebrafish | 2023 |
Effects of compound prebiotics as prophylactic and therapeutic supplementation in a mouse model of acute colitis.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Mesalamine; Mice; Mice, Inbred C57BL; Phylogeny; Pr | 2023 |
5-Aminosalicylic acid alters the gut microbiota and altered microbiota transmitted vertically to offspring have protective effects against colitis.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Mod | 2023 |
An oral cholera vaccine in the prevention and/or treatment of inflammatory bowel disease.
Topics: Animals; Cholera Vaccines; Colitis; Inflammatory Bowel Diseases; Lipopolysaccharides; Mesalamine; Mi | 2023 |
Factors contributing to flares of ulcerative colitis in North India- a case-control study.
Topics: Adult; Anti-Bacterial Agents; Case-Control Studies; Colitis; Colitis, Ulcerative; Female; Humans; In | 2023 |
Effect of Polycan, a β-Glucan from
Topics: Animals; beta-Glucans; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Dextrans; Disease Model | 2023 |
Evaluation of the effect of liposomes loaded with chlorogenic acid in treatment of 2,4,6-trinitrobenzenesulfonic acid-induced murine colitis.
Topics: Animals; Anti-Inflammatory Agents; Chlorogenic Acid; Colitis; Colon; Disease Models, Animal; Inflamm | 2019 |
Dendrobium officinale polysaccharides alleviate colon tumorigenesis via restoring intestinal barrier function and enhancing anti-tumor immune response.
Topics: Animals; Antineoplastic Agents; Carcinogenesis; CD8-Positive T-Lymphocytes; Colitis; Colon; Colorect | 2019 |
Intestinal inflammation increases convulsant activity and reduces antiepileptic drug efficacy in a mouse model of epilepsy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Colitis; Convulsants; Dextran Sul | 2019 |
5-Aminosalicylic Acid Azo-Coupled with a GPR109A Agonist Is a Colon-Targeted Anticolitic Codrug with a Reduced Risk of Skin Toxicity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumor; Chromatography, Liquid; Colitis; | 2020 |
Targeting IL-10, ZO-1 gene expression and IL-6/STAT-3 trans-signalling by a combination of atorvastatin and mesalazine to enhance anti-inflammatory effects and attenuate progression of oxazolone-induced colitis.
Topics: Anti-Inflammatory Agents; Atorvastatin; Colitis; Gene Expression; Humans; Interleukin-10; Interleuki | 2021 |
5-Aminosalicylic Acid Ameliorates Colitis and Checks Dysbiotic Escherichia coli Expansion by Activating PPAR-γ Signaling in the Intestinal Epithelium.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colon; Cytochrome b Group; Dextran Sulfat | 2021 |
Inhibition of PD-1 Protects against TNBS-Induced Colitis via Alteration of Enteric Microbiota.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Gastrointestinal Microbiome; Immune Checkpoint Inhi | 2021 |
Thermosensitive polymer hydrogel as a physical shield on colonic mucosa for colitis treatment.
Topics: Animals; Biocompatible Materials; Colitis; Disease Models, Animal; Drug Carriers; Drug Liberation; H | 2021 |
Identification of a new azoreductase driven prodrug from bardoxolone methyl and 5-aminosalicylate for the treatment of colitis in mice.
Topics: Animals; Colitis; Mesalamine; Mice; Nitroreductases; Oleanolic Acid; Prodrugs | 2021 |
Comparison of anti-inflammatory activities of an anthocyanin-rich fraction from Portuguese blueberries (Vaccinium corymbosum L.) and 5-aminosalicylic acid in a TNBS-induced colitis rat model.
Topics: Animals; Anthocyanins; Anti-Inflammatory Agents; Antioxidants; Blueberry Plants; Colitis; Colon; Cyc | 2017 |
Acetylsalicylic acid-tris-hydroxymethyl-aminomethane reduces colon mucosal damage without causing gastric side effects in a rat model of colitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colitis; Colon; Disease Models, Animal; I | 2018 |
Editorial: evidence is growing for protective effects of 5-aminosalicylates against colitis-associated cancer-authors' reply.
Topics: Colitis; Colitis, Ulcerative; Humans; Mesalamine; Neoplasms | 2017 |
Editorial: evidence is growing for protective effects of 5-aminosalicylates against colitis-associated cancer.
Topics: Colitis; Colitis, Ulcerative; Humans; Mesalamine; Neoplasms | 2017 |
Effect of roxithromycin on mucosal damage, oxidative stress and pro-inflammatory markers in experimental model of colitis.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Diclofenac; Edema; | 2018 |
Antioxidant and anti-inflammatory effect of plumieride in dextran sulfate sodium-induced colitis in mice.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apocynaceae; Cell Line; Colitis; Colitis, Ulcerativ | 2018 |
A colon-specific prodrug of metoclopramide ameliorates colitis in an experimental rat model.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Azo Compounds; Benzenesulfon | 2019 |
Mesalamine and azathioprine modulate junctional complexes and restore epithelial barrier function in intestinal inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Colitis; Epithelial Cells; Inflammat | 2019 |
Improvement of the therapeutic treatment of inflammatory bowel diseases following rectal administration of mesalazine-loaded chitosan microparticles vs Asamax
Topics: Administration, Rectal; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caco-2 Cells; Cell Surviva | 2019 |
Mesalazine Activates Adenosine Monophosphate-activated Protein Kinase: Implication in the Anti-inflammatory Activity of this Anti-colitic Drug.
Topics: AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Enzyme Act | 2019 |
Double Drug Delivery Using Capped Mesoporous Silica Microparticles for the Effective Treatment of Inflammatory Bowel Disease.
Topics: Animals; Colitis; Drug Delivery Systems; Hydrocortisone; Inflammatory Bowel Diseases; Male; Mesalami | 2019 |
Enemas with mesalazine increase the tissue contents of mucins in the colonic mucosa devoid of fecal stream.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colon; Colostomy; Enema; Feces; Gastroint | 2019 |
Therapeutic effectiveness of rectally administered fish oil and mesalazine in trinitrobenzenesulfonic acid-induced colitis.
Topics: Animals; Colitis; Cytokines; Fish Oils; Intestinal Mucosa; Mesalamine; Oxidative Stress; Rats, Wista | 2019 |
Comparative protective effect of hawthorn berry hydroalcoholic extract, atorvastatin, and mesalamine on experimentally induced colitis in rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Atorvastatin; Colitis; Crataegus; Fruit; Heptanoic | 2013 |
[A case of diversion colitis successfully treated with 5-aminosalicylic acid].
Topics: Aged, 80 and over; Colectomy; Colitis; Enema; Humans; Ileostomy; Male; Mesalamine; Postoperative Com | 2013 |
Design and development of novel azo prodrugs using various permutations and combinations of 5- and 4-aminosalicylic acids for inflammatory bowel disease: a colon-targeted approach.
Topics: Aminosalicylic Acid; Animals; Azo Compounds; Colitis; Colon; Drug Design; Female; Humans; Inflammato | 2013 |
Eosinophilic colitis is a sporadic self-limited disease of middle-aged people: a population-based study.
Topics: Abdominal Pain; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Cohort Studies; Colitis; Colon | 2014 |
Heat-killed VSL#3 ameliorates dextran sulfate sodium (DSS)-induced acute experimental colitis in rats.
Topics: Acute Disease; Animals; Colitis; Dextran Sulfate; Disease Models, Animal; Hot Temperature; Interleuk | 2013 |
Acute murine colitis reduces colonic 5-aminosalicylic acid metabolism by regulation of N-acetyltransferase-2.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arylamine N-Acetyltransferase; Colitis; Colon; Dex | 2014 |
Effect of mesalamine and prednisolone on TNBS experimental colitis, following various doses of orally administered iron.
Topics: Administration, Oral; Animals; Colitis; Dietary Supplements; Dose-Response Relationship, Drug; Intes | 2014 |
Arctigenin but not arctiin acts as the major effective constituent of Arctium lappa L. fruit for attenuating colonic inflammatory response induced by dextran sulfate sodium in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arctium; Colitis; Dextran Sulfate; Dose-Response R | 2014 |
Amelioration of trinitrobenzene sulfonic acid-induced colitis in mice by liquiritigenin.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Colon; Cytokines; Disease Models, Animal; Dose-Response | 2015 |
In vivo efficacy of microbiota-sensitive coatings for colon targeting: a promising tool for IBD therapy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cellulose; Colitis; Colon; Dextrins; Drug Delivery | 2015 |
In Vivo Evaluation of 5-ASA Colon-Specific Tablets Using Experimental-Induced Colitis Rat Animal Model.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceutical; C | 2015 |
Dextran-5-(4-ethoxycarbonylphenylazo)salicylic acid ester, a polymeric colon-specific prodrug releasing 5-aminosalicylic acid and benzocaine, ameliorates TNBS-induced rat colitis.
Topics: Administration, Oral; Animals; Benzocaine; Cecum; Colitis; Colon; Dextrans; Inflammation Mediators; | 2016 |
A case of diverticular colitis with lesions resembling ulcerative colitis and correlation of tumor necrosis factor-alpha staining with clinical manifestations.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colitis, Ulcerative; Colonoscopy; Diverticulum, Co | 2015 |
Suppression of colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway by balsalazide and VSL#3.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Azoxymethane; bcl-2-Assoc | 2016 |
1,25-hydroxyvitamin D relieves colitis in rats via down-regulation of toll-like receptor 9 expression.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Disease Models, Animal; Down-Regulation; | 2015 |
5-Aminosalicylic Acid Azo-Linked to Procainamide Acts as an Anticolitic Mutual Prodrug via Additive Inhibition of Nuclear Factor kappaB.
Topics: Animals; Azo Compounds; Colitis; Colon; Male; Mesalamine; NF-kappa B; Procainamide; Prodrugs; Rats; | 2016 |
Mucoadhesive microparticulates based on polysaccharide for target dual drug delivery of 5-aminosalicylic acid and curcumin to inflamed colon.
Topics: Animals; Chitosan; Colitis; Colon; Curcumin; Drug Carriers; Inflammatory Bowel Diseases; Mesalamine; | 2016 |
Surgical Treatment of Crohn Colitis Involving More Than 2 Colonic Segments: Long-Term Outcomes From a Single Institution.
Topics: Adult; Age of Onset; Colectomy; Colitis; Crohn Disease; Female; Humans; Immunosuppressive Agents; Ma | 2016 |
Discovery and preclinical development of a novel prodrug conjugate of mesalamine with eicosapentaenoic acid and caprylic acid for the treatment of inflammatory bowel diseases.
Topics: Aminosalicylic Acids; Animals; Caprylates; Colitis; Colon; Dextran Sulfate; Drug Discovery; Drug Eva | 2016 |
Co-delivery of zinc and 5-aminosalicylic acid from alginate/N-succinyl-chitosan blend microspheres for synergistic therapy of colitis.
Topics: Administration, Oral; Alginates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chitosan; Colitis | 2017 |
The effects of aminosalicylates or thiopurines on the risk of colorectal cancer in inflammatory bowel disease.
Topics: Adult; Aged; Aminosalicylic Acids; Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Co | 2017 |
IBD-Like Features in Syndromic Diarrhea/Trichohepatoenteric Syndrome.
Topics: Anti-Inflammatory Agents; Biological Therapy; Colitis; Colon; Diarrhea; Diarrhea, Infantile; Facies; | 2017 |
Combined Parthenolide and Balsalazide Have Enhanced Antitumor Efficacy Through Blockade of NF-κB Activation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Combined Chemotherapy Protocols; Ap | 2017 |
Jianpi Qingchang decoction alleviates ulcerative colitis by inhibiting nuclear factor-κB activation.
Topics: Animals; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Drugs, Chinese Herbal; Inflammation; | 2017 |
Luminal antioxidants enhance the effects of mesalamine in the treatment of chemically induced colitis in rats.
Topics: Animals; Antioxidants; Ascorbic Acid; Colitis; Cyclic N-Oxides; Disease Models, Animal; Drug Synergi | 2008 |
Effects of N-acetylcysteine plus mesalamine on prostaglandin synthesis and nitric oxide generation in TNBS-induced colitis in rats.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colon; Cyclooxygenase 1; | 2009 |
The targeting of surface modified silica nanoparticles to inflamed tissue in experimental colitis.
Topics: Animals; Caco-2 Cells; Cell Line; Colitis; Colon; Disease Models, Animal; Drug Carriers; Drug Delive | 2008 |
Poly(ethylene glycol)-mesalazine conjugate for colon specific delivery.
Topics: Administration, Oral; Animals; Cell Line; Colitis; Colon; Delayed-Action Preparations; Dextran Sulfa | 2009 |
Segmental colitis associated with diverticulosis syndrome.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Colitis; Diagnosis, Differential; Disease Progression; Dive | 2008 |
Therapeutic effects of rectal administration of muscovite on experimental colitis in rats.
Topics: Administration, Rectal; Aluminum Silicates; Animals; Anti-Inflammatory Agents; Body Weight; Colitis; | 2009 |
[Effect of balsalazide on intestinal mucosal permeability of dextran sulfate sodium-induced colitis in mice].
Topics: Animals; Colitis; Dextran Sulfate; Female; Intestinal Mucosa; Male; Mesalamine; Mice; Mice, Inbred C | 2009 |
Therapeutic effects of Clostridium butyricum on experimental colitis induced by oxazolone in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Butyrates; Calcitonin Gene-Related Peptide; Clostr | 2009 |
Infliximab in the treatment of anti-CTLA4 antibody (ipilimumab) induced immune-related colitis.
Topics: Algorithms; Antibodies, Monoclonal; Antigens, CD; Clinical Trials as Topic; Colitis; CTLA-4 Antigen; | 2009 |
Balsalazine decreases intestinal mucosal permeability of dextran sulfate sodium-induced colitis in mice.
Topics: Animals; Colitis; Dextran Sulfate; Gastrointestinal Agents; Glutathione Peroxidase; Interferon-gamma | 2009 |
An anti-inflammatory mechanism of taurine conjugated 5-aminosalicylic acid against experimental colitis: taurine chloramine potentiates inhibitory effect of 5-aminosalicylic acid on IL-1beta-mediated NFkappaB activation.
Topics: Animals; Anti-Inflammatory Agents; Cell Line, Tumor; Colitis; Dose-Response Relationship, Drug; Drug | 2009 |
Inhibition of colon carcinogenesis by 2-methoxy-5-amino-N-hydroxybenzamide, a novel derivative of mesalamine.
Topics: Aminosalicylic Acids; Animals; Anticarcinogenic Agents; Azoxymethane; Benzamides; Carcinogens; Cell | 2010 |
Oral administration of mesalazine protects against mucosal injury and permeation in dextran sulfate sodium-induced colitis in rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Dextran Sulfate; Di | 2009 |
[A case of segmental colitis associated with diverticular disease].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colon, Sigmoid; Colonoscopy; Diverticulitis, Colon | 2010 |
5-aminosalicylic acid (5-ASA) can reduce levels of oxidative DNA damage in cells of colonic mucosa with and without fecal stream.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colon; DNA Damage; Feces; Hydrogen Peroxi | 2011 |
[Paeoniflorin increases beta-defensin expression and attenuates lesion in the colonic mucosa from mice with oxazolone-induced colitis].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoates; beta-Defensins; Bridged-Ring Compounds; | 2010 |
The prevention of colitis-related cancer by 5-aminosalicylates: an appealing hypothesis that remains unproven.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colorectal Neoplasms; Humans; Mesalamine; Models, | 2011 |
Influence of Shenqing Recipe on morphology and quantity of colonic interstitial cells of Cajal in trinitrobenzene sulfonic acid induced rat colitis.
Topics: Animals; Colitis; Colon; Drugs, Chinese Herbal; Interstitial Cells of Cajal; Male; Medicine, Chinese | 2011 |
Protective effect of aqueous extract of Bombax malabaricum DC on experimental models of inflammatory bowel disease in rats and mice.
Topics: Acetic Acid; Animals; Bombax; Colitis; Disease Models, Animal; Female; India; Indomethacin; Inflamma | 2011 |
N-Succinyl-chitosan systems for 5-aminosalicylic acid colon delivery: in vivo study with TNBS-induced colitis model in rats.
Topics: Absorption; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chitosan; Colitis; Colon; Disease Mode | 2011 |
Beneficial effects of THSG on acetic acid-induced experimental colitis: involvement of upregulation of PPAR-γ and inhibition of the Nf-Κb inflammatory pathway.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Cyclooxygenase 2; Cyclooxyge | 2011 |
Bioadhesive pellets increase local 5-aminosalicylic acid concentration in experimental colitis.
Topics: Animals; Anti-Inflammatory Agents; Biopolymers; Chitosan; Colitis; Colon; Drug Delivery Systems; Dru | 2012 |
Mucosal expression of basic fibroblastic growth factor, Syndecan 1 and tumor necrosis factor-alpha in diverticular disease of the colon: a case-control study.
Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Case | 2012 |
Differential diagnosis and management of histologic eosinophilic colitis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Asthma; Blastocystis hominis; Blastocystis Infections; Coli | 2013 |
An orally administered redox nanoparticle that accumulates in the colonic mucosa and reduces colitis in mice.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Colitis; Colon | 2012 |
Adjunct therapy of n-3 fatty acids to 5-ASA ameliorates inflammatory score and decreases NF-κB in rats with TNBS-induced colitis.
Topics: Animals; Colitis; Fatty Acids, Omega-3; Inflammation; Male; Mesalamine; NF-kappa B; PPAR gamma; Rats | 2013 |
Effect of recombinant Lactobacillus casei expressing interleukin-10 in dextran sulfate sodium-induced colitis mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colon; Dextran Sulfate; Female; Interfero | 2013 |
Exploiting the synergistic effect of chitosan-EDTA conjugate with MSA for the early recovery from colitis.
Topics: Adhesiveness; Animals; Calorimetry, Differential Scanning; Chitosan; Colitis; Colon; Drug Synergism; | 2013 |
Efficacy of drugs used in the treatment of IBD and combinations thereof in acute DSS-induced colitis in mice.
Topics: Aminosalicylic Acids; Animals; Anti-Inflammatory Agents; Budesonide; Colitis; Colon; Cyclosporine; D | 2013 |
Assessment of orocaecal transit time in different localization of Crohn's disease and its possible influence on clinical response to therapy.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Breath Tests; Colitis; Crohn Disease; Delayed- | 2003 |
Collagenous and lymphocytic colitis. evaluation of clinical and histological features, response to treatment, and long-term follow-up.
Topics: Aged; Budesonide; Cholestyramine Resin; Colitis; Collagen; Colon; Female; Follow-Up Studies; Humans; | 2003 |
Successful use of mesalamine in the treatment of chronic segmental lesion in a case of ischemic colitis.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Colitis; Female; | 2003 |
Collagenous colitis associated with Clostridium difficile: a cause effect?
Topics: Aged; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Clostridioides difficile; Coli | 2003 |
The intestinal anti-inflammatory activity of UR-12746S on reactivated experimental colitis is mediated through downregulation of cytokine production.
Topics: Aminosalicylic Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aza Compounds; Azo Compounds | 2003 |
5-ASA and lycopene decrease the oxidative stress and inflammation induced by iron in rats with colitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; beta Carotene; Carotenoids; Colitis; | 2004 |
Effect of mesalazine, metronidazole and gentamicin on bacterial translocation in experimental colitis.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Bacterial Translocation; Co | 2004 |
Oxazolone-induced colitis in BALB/C mice: a new method to evaluate the efficacy of therapeutic agents for ulcerative colitis.
Topics: Animals; Colitis; Colitis, Ulcerative; Dose-Response Relationship, Drug; Drug Evaluation, Preclinica | 2004 |
Lymphtoxin beta receptor-Ig ameliorates TNBS-induced colitis via blocking LIGHT/HVEM signaling.
Topics: Animals; CD4-Positive T-Lymphocytes; Colitis; Colon; Disease Models, Animal; Gene Expression Regulat | 2005 |
Liposomal formulations of inflammatory bowel disease drugs: local versus systemic drug delivery in a rat model.
Topics: Algorithms; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Transport, Active; Caco-2 C | 2005 |
Up-regulation of anandamide levels as an endogenous mechanism and a pharmacological strategy to limit colon inflammation.
Topics: Adult; Aged; Amidohydrolases; Animals; Arachidonic Acids; Benzenesulfonates; Colitis; Colitis, Ulcer | 2006 |
A molecular mechanism for the anti-inflammatory effect of taurine-conjugated 5-aminosalicylic acid in inflamed colon.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Chromatography, High Pressure Liquid; C | 2006 |
Evaluation of 5-aminosalicyltaurine as a colon-specific prodrug of 5-aminosalicylic acid for treatment of experimental colitis.
Topics: Aminosalicylic Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressur | 2006 |
Effects of topical treatment of sodium butyrate and 5-aminosalicylic acid on expression of trefoil factor 3, interleukin 1beta, and nuclear factor kappaB in trinitrobenzene sulphonic acid induced colitis in rats.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Butyrates; Colitis; Inter | 2006 |
Antioxidant therapy with N-acetylcysteine plus mesalamine accelerates mucosal healing in a rodent model of colitis.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Biopsy, Needle; Coli | 2006 |
Herpes simplex virus colitis in ulcerative colitis, simulating malignancy.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colitis, Ulcerative; Diagnosis, Differentia | 2006 |
[Lymphocitic colitis and celiac disease].
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Celiac Disease; Colitis; Female; Humans; Mesalamine | 2006 |
Azathioprine and mesalazine-induced effects on the mucosal flora in patients with IBD colitis.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Bacteria; Bacterial Adhesion; Colitis; | 2007 |
Enhanced activity of a hydrogen sulphide-releasing derivative of mesalamine (ATB-429) in a mouse model of colitis.
Topics: Animals; Anti-Inflammatory Agents; Chemokines; Colitis; Colon; Cytokines; Disease Models, Animal; Di | 2007 |
Effects of Ginkgo biloba extract on inflammatory mediators (SOD, MDA, TNF-alpha, NF-kappaBp65, IL-6) in TNBS-induced colitis in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Base Sequence; Colitis; Ginkgo bilob | 2006 |
Colon-specific delivery of 5-aminosalicylic acid from chitosan-Ca-alginate microparticles.
Topics: Alginates; Animals; Anti-Inflammatory Agents, Non-Steroidal; B-Lymphocytes; Body Weight; Calcium; Ca | 2007 |
Protective effects of 2,3,5,4'-tetrahydroxystilbene-2-O-beta-d-glucoside, an active component of Polygonum multiflorum Thunb, on experimental colitis in mice.
Topics: Acetic Acid; Acute Disease; Animals; Anti-Inflammatory Agents; Antioxidants; Chronic Disease; Coliti | 2008 |
5-aminosalicylic acid given in the remission stage of colitis suppresses colitis-associated cancer in a mouse colitis model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Colitis; Colitis, Ulcerative; Disease | 2007 |
Reduction of peroxisome proliferation-activated receptor gamma expression by gamma-irradiation as a mechanism contributing to inflammatory response in rat colon: modulation by the 5-aminosalicylic acid agonist.
Topics: Animals; Colitis; Colon; Gamma Rays; Gene Expression Regulation; Inflammation; Male; Mesalamine; PPA | 2008 |
The involvement of heme oxygenase-1 activity in the therapeutic actions of 5-aminosalicylic acid in rat colitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Blotting, Western; Colitis; Disease | 2008 |
The effect of propolisis and mesalazine on bacterial translocation in an experimental colitis model.
Topics: Animals; Anti-Infective Agents; Bacterial Translocation; Colitis; Mesalamine; Propolis; Terminology | 2008 |
Natural history and long-term clinical behavior of segmental colitis associated with diverticulosis (SCAD syndrome).
Topics: Abdominal Pain; Adult; Age Distribution; Aged; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Dia | 2008 |
5-aminosalicylic acid inhibits colitis-associated colorectal dysplasias in the mouse model of azoxymethane/dextran sulfate sodium-induced colitis.
Topics: Animals; Azoxymethane; Colitis; Colorectal Neoplasms; Cyclooxygenase 2; Dextran Sulfate; Disease Mod | 2008 |
5-aminosalicylic acid in serum and urine after administration by enema to patients with colitis.
Topics: Adult; Aged; Aminosalicylic Acids; Colitis; Enema; Female; Humans; Male; Mesalamine; Middle Aged | 1983 |
The prophylactic effect of 5-aminosalicylic acid and salazosulphapyridine on degraded-carrageenan-induced colitis in guinea pigs.
Topics: Aminosalicylic Acids; Animals; Carrageenan; Cecum; Colitis; Delayed-Action Preparations; Drug Evalua | 1984 |
[Current therapeutic possibilities in chronic inflammatory intestinal diseases].
Topics: Aminosalicylic Acids; Chronic Disease; Colitis; Colitis, Ulcerative; Crohn Disease; Drug Therapy, Co | 1995 |
Production of interleukin-1b and tumor necrosis factor--a by peripheral blood human mononuclear cells in active and inactive stages of ulcerative colitis.
Topics: Administration, Oral; Adolescent; Adult; Aminosalicylic Acids; Anti-Inflammatory Agents, Non-Steroid | 1995 |
Butyrate, mesalamine, and factor XIII in experimental colitis in the rat: effects on transglutaminase activity.
Topics: Aminosalicylic Acids; Animals; Butyrates; Butyric Acid; Colitis; Factor XIII; Male; Mesalamine; Rats | 1994 |
[Effect of mesalazine microgranules on experimental colitis].
Topics: Aminosalicylic Acids; Animals; Carrageenan; Colitis; Delayed-Action Preparations; Guinea Pigs; Male; | 1994 |
Mesalamine therapy in Reiter's syndrome.
Topics: Adult; Aminosalicylic Acids; Arthritis, Reactive; Colitis; Gastroenteritis; Humans; Ileitis; Male; M | 1994 |
[Iatrogenic diffuse interstitial pneumonia linked to 5-aminosalicylate].
Topics: Aminosalicylic Acids; Colitis; Drug Therapy, Combination; Female; Gastrointestinal Hemorrhage; Human | 1994 |
Effect of epidermal growth factor on experimental colitis in the rat.
Topics: Aminosalicylic Acids; Animals; Colitis; Colon; Disease Models, Animal; Eicosanoids; Epidermal Growth | 1993 |
NPC 15669, an inhibitor of neutrophil recruitment, is efficacious in acetic acid-induced colitis in rats.
Topics: Acetates; Acetic Acid; Aminosalicylic Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capil | 1993 |
Distribution and anti-inflammatory effect of mesalazine on carrageenan-induced colitis in the rabbit.
Topics: Aminosalicylic Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Carrageenan; Co | 1996 |
Regional enteritis complicating malignant lymphoma.
Topics: Adult; Aminosalicylic Acids; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti | 1996 |
Evaluating the antioxidant potential of new treatments for inflammatory bowel disease using a rat model of colitis.
Topics: Acetic Acid; Aminosalicylic Acids; Animals; Antioxidants; Butylated Hydroxytoluene; Colitis; Colitis | 1996 |
Intracolonic administration of zileuton, a selective 5-lipoxygenase inhibitor, accelerates healing in a rat model of chronic colitis.
Topics: Aminosalicylic Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Colitis; Co | 1996 |
Influence of topical rectal application of drugs on dextran sulfate-induced colitis in rats.
Topics: Administration, Rectal; Aminosalicylic Acids; Anesthetics, Local; Animals; Anti-Inflammatory Agents; | 1997 |
Diversion colitis: a cause of abdominal discomfort in spinal cord injury patients with colostomy.
Topics: Abdominal Pain; Aminosalicylic Acids; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colostomy; H | 1997 |
Safety of topical 5-aminosalicylic acid in pregnancy.
Topics: Abnormalities, Drug-Induced; Administration, Topical; Adult; Anti-Inflammatory Agents, Non-Steroidal | 1997 |
[Collagenous colitis: presentation of 12 cases].
Topics: Adult; Aged; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Inflammato | 1997 |
Oxazolone-induced colitis in rats: effects of budesonide, cyclosporin A, and 5-aminosalicylic acid.
Topics: Animals; Budesonide; Colitis; Colon; Cyclosporine; Disease Models, Animal; Female; Intestinal Mucosa | 1998 |
[Crohn's disease and pregnancy. A case report].
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Crohn Disease; Female; Humans; Infant, Newb | 1998 |
Antioxidant effects of aminosalicylates and potential new drugs for inflammatory bowel disease: assessment in cell-free systems and inflamed human colorectal biopsies.
Topics: Adrenal Cortex Hormones; Adult; Aged; Aminosalicylic Acid; Aminosalicylic Acids; Anti-Infective Agen | 1999 |
Anti-inflammatory activity of phycocyanin extract in acetic acid-induced colitis in rats.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents; Colitis; Eukaryota; Male; Mesalamine; Microscopy, El | 1999 |
[56-year-old patient with segmental florid colitis and colonic amyloidosis].
Topics: Amyloidosis; Azathioprine; Colitis; Colonic Diseases; Colonoscopy; Crohn Disease; Diagnosis, Differe | 1999 |
Enhanced anti-inflammatory effects of a nitric oxide-releasing derivative of mesalamine in rats.
Topics: Aminosalicylic Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caspase 1; Cell Adhesion; Ce | 1999 |
Lack of evidence for fibrosing colonopathy by 5-ASA in humans.
Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Fibrosis; Humans; Intestinal | 1999 |
L-glutamine enemas attenuate mucosal injury in experimental colitis.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Enema; Fatty Ac | 1999 |
Beneficial effects of ropivacaine in rat experimental colitis.
Topics: Acetylcholine; Amides; Anesthetics, Local; Animals; Budesonide; Colitis; Ethanol; Gastrointestinal M | 1999 |
Validation of a pharmacokinetic model of colon-specific drug delivery and the therapeutic effects of chitosan capsules containing 5-aminosalicylic acid on 2,4,6-trinitrobenzenesulphonic acid-induced colitis in rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsules; Chitin; Chitosan; | 1999 |
Therapeutic role for bismuth compounds in TNBS-induced colitis in the rat.
Topics: Animals; Anti-Ulcer Agents; Bismuth; Colitis; Female; Mesalamine; Organometallic Compounds; Rats; Ra | 2000 |
Segmental colitis associated with diverticula: a prospective study. Gruppo di Studio per le Malattie Infiammatorie Intestinali (GSMII).
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colonoscopy; Diverticulit | 2000 |
Short- and long-term follow-up of treatment for lymphocytic and collagenous colitis.
Topics: Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Collagen; Diarrhea | 2000 |
Intestinal anti-inflammatory activity of UR-12746, a novel 5-ASA conjugate, on acute and chronic experimental colitis in the rat.
Topics: Acute Disease; Aminosalicylic Acids; Animals; Anti-Inflammatory Agents; Aza Compounds; Chronic Disea | 2000 |
Does the initial location of Crohn's disease have an influence on the time-to-relapse in patients under maintenance treatment with oral mesalamine?
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Crohn Disease; Female | 2000 |
The effect of local attachment of cationized antioxidant enzymes on experimental colitis in the rat.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Betamethas | 2000 |
Treatment responses in collagenous colitis.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; A | 2001 |
Familial microscopic colitis.
Topics: Abdominal Pain; Adult; Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Colitis; Colonoscopy; Consti | 2001 |
[Collagenous colitis. A study of 11 cases].
Topics: Adult; Agammaglobulinemia; Aged; Aged, 80 and over; Anemia; Anti-Inflammatory Agents; Anti-Inflammat | 2001 |
Gut inflammation targeted in UCLA HIV study.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Colitis; HIV Infections; Humans; | 2000 |
Clinical and histological predictors of response to medical therapy in collagenous colitis.
Topics: Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; An | 2002 |
Induction of colitis in rats by 2-2'-azobis(2-amidinopropane) dihydrochloride.
Topics: Amidines; Aminosalicylic Acids; Animals; Benzopyrans; Colitis; Inflammation; Intestinal Mucosa; Lipi | 1992 |
Effect of aminophenols (5-ASA and 4-ASA) on colonic interleukin-1 generation.
Topics: Aminosalicylic Acid; Aminosalicylic Acids; Animals; Colitis; Colon; Disease Models, Animal; Humans; | 1992 |
Sequential histologic evaluations in collagenous colitis. Correlations with disease behavior and sampling strategy.
Topics: Adult; Aged; Aminosalicylic Acids; Colitis; Collagen; Colon; Female; Humans; Intestinal Mucosa; Male | 1992 |
A case of diversion colitis treated with 5-aminosalicylic acid enemas.
Topics: Aged; Aged, 80 and over; Aminosalicylic Acids; Colitis; Colostomy; Diverticulum, Colon; Enema; Femal | 1992 |
Misoprostol therapy following trinitrobenzene sulfonic acid-induced colitis accelerates healing.
Topics: Aminosalicylic Acids; Animals; Betamethasone; Colitis; Intestinal Absorption; Intestinal Mucosa; Mal | 1992 |
Mesalazine release from coated tablets: effect of dietary fibre.
Topics: Adult; Aged; Aminosalicylic Acids; Colitis; Dietary Fiber; Feces; Female; Humans; Hydrogen-Ion Conce | 1991 |
Azathioprine reduces extravasation and neutrophil trafficking in immune complex-mediated inflammation in the rat colon.
Topics: Aminosalicylic Acids; Animals; Antigen-Antibody Complex; Azathioprine; Colitis; Evans Blue; Male; Me | 1991 |
Treatment of diversion colitis with 5-aminosalicylic acid enemas: comparison with betamethasone enemas.
Topics: Aminosalicylic Acids; Betamethasone; Colitis; Enema; Female; Humans; Mesalamine; Middle Aged; Postop | 1991 |
Participation of thromboxane and other eicosanoid synthesis in the course of experimental inflammatory colitis.
Topics: 6-Ketoprostaglandin F1 alpha; Aminosalicylic Acids; Animals; Colitis; Dinoprostone; Indomethacin; Le | 1990 |
Familial occurrence of collagenous colitis. A report of two families.
Topics: Adult; Aged; Aminosalicylic Acids; Biopsy; Colitis; Collagen; Diarrhea; Female; Humans; Intestinal M | 1990 |
Coeliac disease and collagenous colitis.
Topics: Adult; Aminosalicylic Acids; Celiac Disease; Colitis; Diarrhea; Humans; Jejunum; Male; Mesalamine; R | 1990 |
Inhibition of leukotriene synthesis markedly accelerates healing in a rat model of inflammatory bowel disease.
Topics: 6-Ketoprostaglandin F1 alpha; Aminosalicylic Acids; Animals; Chronic Disease; Colitis; Colon; Leukot | 1989 |
Enemas for IBD maintenance therapy.
Topics: Aminosalicylic Acids; Colitis; Enema; Humans; Mesalamine; Proctocolitis | 1989 |
A possible mechanism of action of sulfasalazine and 5-aminosalicylic acid in inflammatory bowel diseases: interaction with oxygen free radicals.
Topics: Aminosalicylic Acids; Animals; Chemical Phenomena; Chemistry; Colitis; Free Radicals; Humans; Indome | 1985 |
Keratoconjunctivitis sicca and the treatment of canine colitis.
Topics: Aminosalicylic Acids; Animals; Colitis; Dog Diseases; Dogs; Female; Keratoconjunctivitis; Keratoconj | 1986 |
High-performance liquid chromatographic assay of 5-aminosalicylic acid and its acetylated metabolite in biological fluids using electrochemical detection.
Topics: Acetylation; Aminosalicylic Acids; Chromatography, High Pressure Liquid; Colitis; Electrochemistry; | 1988 |