mesalamine has been researched along with Chemical and Drug Induced Liver Injury in 16 studies
Mesalamine: An anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the active moiety of SULPHASALAZINE. (From Martindale, The Extra Pharmacopoeia, 30th ed)
mesalamine : A monohydroxybenzoic acid that is salicylic acid substituted by an amino group at the 5-position.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 42-yr-old man with ulcerative colitis was admitted for investigation of prolonged fever associated with cholestatic liver tests." | 5.30 | Mesalamine-induced granulomatous hepatitis. ( Braun, M; Fraser, GM; Kunin, M; Salamon, F; Tur-Kaspa, R, 1999) |
| "Mesalazine is an aminosalicillic derivative considered as a safe alternative to the relative frequency (5-55%) of adverse effects observed with sulfasalazine." | 2.40 | [Non-immunoallergic hepatotoxicity due to mesalazine]. ( Barroso, N; Gavilán, F; Guil, A; Larrauri, J; Leo, E; Reina, FR; Tirado, C; Zafra, C, 1999) |
| " This case reinforces the possibility of a causal relationship between mesalazine therapy and toxic hepatic injury without systemic hypersensitivity." | 1.62 | "Hepatotoxicity in inflammatory bowel disease: mesalazine, the forgotten drug". ( Garrido, I; Lopes, J; Lopes, S; Macedo, G; Santos, AL, 2021) |
| "5-aminosalicylates are extensively prescribed for the treatment of ulcerative colitis but have a wide range of described adverse effects." | 1.31 | Sulphasalazine and mesalazine: serious adverse reactions re-evaluated on the basis of suspected adverse reaction reports to the Committee on Safety of Medicines. ( Langman, MJ; Ransford, RA, 2002) |
| "A 42-yr-old man with ulcerative colitis was admitted for investigation of prolonged fever associated with cholestatic liver tests." | 1.30 | Mesalamine-induced granulomatous hepatitis. ( Braun, M; Fraser, GM; Kunin, M; Salamon, F; Tur-Kaspa, R, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (12.50) | 18.7374 |
| 1990's | 2 (12.50) | 18.2507 |
| 2000's | 3 (18.75) | 29.6817 |
| 2010's | 8 (50.00) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 2 |
| Warner, DJ | 1 |
| Chen, H | 1 |
| Cantin, LD | 1 |
| Kenna, JG | 1 |
| Stahl, S | 1 |
| Walker, CL | 1 |
| Noeske, T | 1 |
| Chen, M | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Garrido, I | 1 |
| Santos, AL | 1 |
| Lopes, J | 1 |
| Lopes, S | 1 |
| Macedo, G | 1 |
| Domínguez Jiménez, JL | 1 |
| Pelado García, EM | 1 |
| Copado Herrera, R | 1 |
| Stelzer, T | 1 |
| Kohler, S | 1 |
| Marques Maggio, E | 1 |
| Heuss, LT | 1 |
| Andrejic, J | 1 |
| Rojas-Balcazar, J | 1 |
| Dennis, M | 1 |
| Berkelhammer, C | 1 |
| Masuda, H | 1 |
| Takahashi, Y | 1 |
| Nishida, Y | 1 |
| Asai, S | 1 |
| Ransford, RA | 1 |
| Langman, MJ | 1 |
| Soto-Fernández, S | 1 |
| González-Carro, P | 1 |
| De Pedro-Esteban, A | 1 |
| Legaz-Huidobro, ML | 1 |
| Pérez-Roldán, F | 1 |
| Roncero García-Escribano, O | 1 |
| Valbuena-González, M | 1 |
| Ruiz-Carrillo, F | 1 |
| Barroso, N | 1 |
| Leo, E | 1 |
| Guil, A | 1 |
| Larrauri, J | 1 |
| Tirado, C | 1 |
| Zafra, C | 1 |
| Gavilán, F | 1 |
| Reina, FR | 1 |
| Braun, M | 1 |
| Fraser, GM | 1 |
| Kunin, M | 1 |
| Salamon, F | 1 |
| Tur-Kaspa, R | 1 |
| Hartleb, M | 1 |
| Biernat, L | 1 |
| Kochel, A | 1 |
| Pineda, JR | 1 |
| Leal, JC | 1 |
| de la Morena, E | 1 |
| Abreu, L | 1 |
| Burke, DA | 1 |
| Manning, AP | 1 |
| Williamson, JM | 1 |
| Axon, AT | 1 |
3 reviews available for mesalamine and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
[Non-immunoallergic hepatotoxicity due to mesalazine].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Colitis; Diagnosis, | 1999 |
Drug-induced liver damage -- a three-year study of patients from one gastroenterological department.
Topics: Adult; Aged; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anticholesteremic Agent | 2002 |
13 other studies available for mesalamine and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
"Hepatotoxicity in inflammatory bowel disease: mesalazine, the forgotten drug".
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Cholestasis; Coliti | 2021 |
[Mesalazine-induced acute hepatitis].
Topics: Administration, Oral; Alanine Transaminase; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Dr | 2015 |
An unusual cause of febrile hepatitis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Chemical and Drug Induced Liver Injury; Cholestasis | 2015 |
Azathioprine-induced hypersensitivity hepatitis: tolerance to 6-mercaptopurine.
Topics: Acute Disease; Azathioprine; Chemical and Drug Induced Liver Injury; Colitis, Ulcerative; Drug Hyper | 2010 |
Comparison of the effect of mesalazine and sulfasalazine on laboratory parameters: a retrospective observational study.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Cohort Studi | 2012 |
Sulphasalazine and mesalazine: serious adverse reactions re-evaluated on the basis of suspected adverse reaction reports to the Committee on Safety of Medicines.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Inju | 2002 |
[Infliximab-induced hepatitis in a patient with Crohn's disease].
Topics: Acute Disease; Adult; Antibodies, Monoclonal; Azathioprine; Chemical and Drug Induced Liver Injury; | 2006 |
Mesalamine-induced granulomatous hepatitis.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Colitis, Ulc | 1999 |
[Hepatotoxicity: a new side effect of 5-aminosalicylic acid].
Topics: Adult; Aminosalicylic Acids; Chemical and Drug Induced Liver Injury; Humans; Male; Mesalamine | 1989 |
Adverse reactions to sulphasalazine and 5-amino salicylic acid in the same patient.
Topics: Adult; Aminosalicylic Acids; Chemical and Drug Induced Liver Injury; Humans; Male; Mesalamine; Sulfa | 1987 |