mesalamine and Acute Disease studies

Mesalamine: An anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the active moiety of SULPHASALAZINE. (From Martindale, The Extra Pharmacopoeia, 30th ed)
mesalamine : A monohydroxybenzoic acid that is salicylic acid substituted by an amino group at the 5-position.

Research Excerpts

Excerpt	Relevance	Reference
"This was a 1-year double-blind, randomized, placebo-controlled study in which patients with computed tomography scan confirmed acute diverticulitis received placebo, mesalamine, or mesalamine+Bifidobacterium infantis 35624 (Align) for 12 weeks and followed for 9 additional months."	9.17	A randomized controlled study of mesalamine after acute diverticulitis: results of the DIVA trial. ( Magowan, S; Quigley, EM; Shanahan, F; Stollman, N, 2013)
"Twenty patients who developed diarrhea-predominant IBS after gastroenteritis were randomized to receive mesalamine (Asacol®) 1."	9.16	Double-blind placebo-controlled study of mesalamine in post-infective irritable bowel syndrome--a pilot study. ( Al-Suqi, M; Fang, JC; Hale, DC; Stoddard, GJ; Tuteja, AK, 2012)
"To evaluate the impact of mesalamine administration on inflammatory response in acute uncomplicated diverticulitis."	7.81	Effect of oral mesalamine on inflammatory response in acute uncomplicated diverticulitis. ( Bernasconi, DP; Gianotti, L; Lo Bianco, G; Nespoli, A; Nespoli, L; Romano, F; Uggeri, F, 2015)
"Drug-induced acute pancreatitis (DIAP) is an often-neglected entity where the disorder is the consequence of the toxic effects of various agents applied to treat potentially life-threatening conditions, such as inflammatory bowel disease."	5.56	Recurrent acute pancreatitis induced by 5-ASA and azathioprine in ulcerative colitis. ( Bajor, J; Faluhelyi, N; Hegyi, P; Hegyi, PJ; Németh, BC; Szakács, Z, 2020)
"AZA-induced acute pancreatitis is always mild."	5.35	Acute pancreatitis in inflammatory bowel disease, with special reference to azathioprine-induced pancreatitis. ( Algaba, A; Bermejo, F; Calvo, M; Carneros, JA; Gisbert, JP; López, P; Lopez-Sanroman, A; Luna, M; Martín-Arranz, MD; Menchén, L; Mendoza, JL; Opio, V; Pérez-Calle, JL; Taxonera, C; Van-Domselaar, M; Vera, I, 2008)
"This was a 1-year double-blind, randomized, placebo-controlled study in which patients with computed tomography scan confirmed acute diverticulitis received placebo, mesalamine, or mesalamine+Bifidobacterium infantis 35624 (Align) for 12 weeks and followed for 9 additional months."	5.17	A randomized controlled study of mesalamine after acute diverticulitis: results of the DIVA trial. ( Magowan, S; Quigley, EM; Shanahan, F; Stollman, N, 2013)
"Twenty patients who developed diarrhea-predominant IBS after gastroenteritis were randomized to receive mesalamine (Asacol®) 1."	5.16	Double-blind placebo-controlled study of mesalamine in post-infective irritable bowel syndrome--a pilot study. ( Al-Suqi, M; Fang, JC; Hale, DC; Stoddard, GJ; Tuteja, AK, 2012)
"Sulfasalazine, consisting of 5-aminosalicylic acid bound to sulfapyridine by a diazo bond, was first used for treatment of ulcerative colitis in the early 1940s and later found effective in placebo-controlled trials for acute disease and for long-term maintenance of remission."	4.81	Role of mesalazine in acute and long-term treatment of ulcerative colitis and its complications. ( Schroeder, KW, 2002)
"To evaluate the impact of mesalamine administration on inflammatory response in acute uncomplicated diverticulitis."	3.81	Effect of oral mesalamine on inflammatory response in acute uncomplicated diverticulitis. ( Bernasconi, DP; Gianotti, L; Lo Bianco, G; Nespoli, A; Nespoli, L; Romano, F; Uggeri, F, 2015)
" In this study, we examined the effects of 2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside (THSG), an active component extracted from Polygonum multiflorum Thunb, on acetic acid-induced acute colitis and mitomycin C-induced chronic colitis."	3.74	Protective effects of 2,3,5,4'-tetrahydroxystilbene-2-O-beta-d-glucoside, an active component of Polygonum multiflorum Thunb, on experimental colitis in mice. ( Chen, S; Han, T; Wang, J; Wang, X; Zhao, L, 2008)
"Acute pancreatitis is a known, although rare, complication of mesalamine treatment."	3.69	Acute pancreatitis after long-term 5-aminosalicylic acid therapy. ( Fernández, J; Feu, F; Navarro, S; Panés, J; Sala, M; Terés, J, 1997)
"Many patients with ulcerative colitis (UC) respond to mesalamine therapy within 8 weeks."	2.74	Effect of extended MMX mesalamine therapy for acute, mild-to-moderate ulcerative colitis. ( Barrett, K; Joseph, R; Kamm, MA; Lees, K; Lichtenstein, GR; Sandborn, WJ; Schreiber, S, 2009)
"Patients with ulcerative colitis have a higher rate of tubular nephropathies."	2.72	[Characterization of proteinuria in patients with ulcerative colitis and therapy with aminosalicylates]. ( Aymaz, S; Buschhausen, L; Krakamp, B; Kruis, W; Weber, M, 2006)
"Balsalazide is a new-generation 5-ASA drug that yields a high concentration of active drug to the distal colon."	2.71	Prevention of acute radiation-induced proctosigmoiditis by balsalazide: a randomized, double-blind, placebo controlled trial in prostate cancer patients. ( Bettenhausen, D; Jahraus, CD; Malik, U; Sellitti, M; St Clair, WH, 2005)
"Balsalazide is a novel azo-bonded 5-aminosalicylic acid treatment for mild-to-moderate ulcerative colitis."	2.70	Balsalazide is superior to mesalamine in the time to improvement of signs and symptoms of acute mild-to-moderate ulcerative colitis. ( Cross, A; Doty, P; Hanson, J; Hardi, R; Johanson, J; Johnson, LK; Koval, G; Pruitt, R; Riff, D; Safdi, M; Winston, B; Wruble, L, 2002)
" No dose-response relation was demonstrated."	2.69	Dose-ranging study of mesalamine (PENTASA) enemas in the treatment of acute ulcerative proctosigmoiditis: results of a multicentered placebo-controlled trial. The U.S. PENTASA Enema Study Group. ( Hanauer, SB, 1998)
"Prednisolone treated patients had significantly fewer days with liquid stools than mesalazine patients, with a median of 0 and 1 days respectively by week 4 (p = 0."	2.68	A randomised trial comparing mesalazine and prednisolone foam enemas in patients with acute distal ulcerative colitis. ( Daniels, S; Grace, RH; Jewell, DP; Keighley, MR; Kingston, RD; Lee, FI; Mani, V; Patterson, J; Record, CO; Smith, K, 1996)
" Patients were randomly assigned to receive 5-ASA at a dosage of either 4."	2.66	Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. ( Ilstrup, DM; Schroeder, KW; Tremaine, WJ, 1987)
"The incidence of diverticulosis and diverticular disease of the colon is increasing worldwide."	2.61	Diverticulosis today. ( Brandimarte, G; Elisei, W; Tursi, A, 2019)
"Here, we report a case of recurrent acute pancreatitis secondary to 5-aminosalicylic acid, with positive unintentional rechallenge."	2.58	5-ASA induces mild acute pancreatitis. Case report and review of the literature. ( Hegyi, P; Meczker, Á; Mikó, A, 2018)
" Only randomized clinical trials (RCTs) (irrespective of language, blinding, or publication status), which compared mesalazine, irrespective of the dosage assumption, with placebo in SUDD were evaluated."	2.58	Mesalazine to treat symptomatic uncomplicated diverticular disease and to prevent acute diverticulitis occurrence. A systematic review with meta-analysis of randomized, placebo-controlled trials. ( Elisei, W; Picchio, M; Tursi, A, 2018)
"Acute severe ulcerative colitis (ASC) is a potentially life-threatening disease."	2.47	Consensus for managing acute severe ulcerative colitis in children: a systematic review and joint statement from ECCO, ESPGHAN, and the Porto IBD Working Group of ESPGHAN. ( Alex, G; Baldassano, RN; Benchimol, EI; Bousvaros, A; Cucchiara, S; Dubinsky, M; Escher, JC; Griffiths, AM; Hyams, JS; Langer, JC; Levine, A; Markowitz, J; Ruemmele, FM; Russell, RK; Shamberger, R; Travis, SP; Turner, D; van Assche, G; Wilson, DC, 2011)
"Although infrequent, acute pancreatitis, and less often chronic pancreatitis, may occur as a result of the disease itself or secondary to the medications used in the treatment."	2.46	Pancreatitis in inflammatory bowel diseases. ( Das, K; Pitchumoni, CS; Rubin, A, 2010)
"The therapy of inflammatory bowel diseases is based on 5-aminosalicylates (5-ASAs) that are the forefront of treatment of mild-to-moderate active disease and maintenance; steroids are used for the treatment of moderate-to-severe active disease; immunosuppressives and sometimes antibiotics in moderate-to-severe disease; maintenance and for the treatment of selected complications."	2.44	[Medical therapy of inflammatory bowel diseases: Crohn's disease]. ( Lakatos, L; Lakatos, PL, 2007)
"Radiation enteritis is a severe problem in patients receiving irradiation of the abdomen or pelvis in the course of cancer treatment."	2.44	Medical prevention and treatment of acute and chronic radiation induced enteritis--is there any proven therapy? a short review. ( Böcker, U; Singer, MV; Wenz, F; Zimmerer, T, 2008)
"The diagnostic work-up of ulcerative colitis at presentation is based on the collection of clinical, microbiological, radiological, endoscopic and histologic data."	2.42	Review article: diagnosis, monitoring and treatment of distal colitis. ( De Franchis, R; Devani, M; Rondonotti, E; Saibeni, S; Vecchi, M, 2003)
"It describes the treatment of ulcerative colitis according to the different groups of patients and the degree of activity."	2.41	[Conservative therapy of inflammatory bowel diseases]. ( Nagy, F, 2002)
"Often, relapse is related to the failure of maintenance therapy."	2.40	Factors influencing the relapse of patients with inflammatory bowel disease. ( Miner, PB, 1997)
"This is the first report of acute pancreatitis developed by oral 5-ASA therapy for the treatment of ulcerative colitis in the literature of Japan."	2.40	Acute pancreatitis secondary to 5-aminosalicylic acid therapy in a patient with ulcerative colitis. ( Adachi, E; Chiba, T; Kawanami, C; Matsushima, Y; Nakamura, T; Nakase, H; Okazaki, K; Seno, H; Uchida, K, 1999)
"Drug-induced acute pancreatitis (DIAP) is an often-neglected entity where the disorder is the consequence of the toxic effects of various agents applied to treat potentially life-threatening conditions, such as inflammatory bowel disease."	1.56	Recurrent acute pancreatitis induced by 5-ASA and azathioprine in ulcerative colitis. ( Bajor, J; Faluhelyi, N; Hegyi, P; Hegyi, PJ; Németh, BC; Szakács, Z, 2020)
"He had been diagnosed as ulcerative colitis (UC) and taking mesalazine for two months."	1.36	[A case of inferior vena cava thrombosis and acute pancreatitis in a patient with ulcerative colitis]. ( Chang, DK; Kim, CH; Kim, KH; Lee, JK; Lee, KH; Lee, KT; Park, SH; Shin, DH, 2010)
"Azathioprine was the most frequent causative factor (three cases in two patients); all the other causative drugs were documented only in single cases: mesalazine, dexamethasone, ramipril, mycophenolate mofetil, cytarabine, and valproate."	1.36	Incidence, severity, and etiology of drug-induced acute pancreatitis. ( Procházka, M; Procházka, V; Urbánek, K; Vinklerová, I, 2010)
"Acute pancreatitis is a serious disease with fatality rate up to 15%."	1.35	[A case of acute pancreatitis induced by multiple drugs in a patient with ulcerative colitis]. ( Choi, HS; Hahm, JS; Han, DS; Joo, YW; Lee, HL; Lee, OY; Son, CN; Yoon, BC, 2008)
"AZA-induced acute pancreatitis is always mild."	1.35	Acute pancreatitis in inflammatory bowel disease, with special reference to azathioprine-induced pancreatitis. ( Algaba, A; Bermejo, F; Calvo, M; Carneros, JA; Gisbert, JP; López, P; Lopez-Sanroman, A; Luna, M; Martín-Arranz, MD; Menchén, L; Mendoza, JL; Opio, V; Pérez-Calle, JL; Taxonera, C; Van-Domselaar, M; Vera, I, 2008)
"A 15-year-old female with ulcerative colitis developed polyuria, polydipsia, vomiting, and fatigue."	1.34	Acute tubular injury associated with mesalazine therapy in an adolescent girl with inflammatory bowel disease. ( Demir, H; Gürakan, F; Saltik-Temizel, IN; Topaloğlu, R; Uslu, N; Yüce, A, 2007)
"Pericarditis is an uncommon extraintestinal manifestation of inflammatory bowel disease (IBD), which may occur at any time during its natural course."	1.34	Parallel manifestation of Crohn's disease and acute pericarditis: a report of two cases. ( Kaziani, A; Mantzaris, G; Roussos, A; Skoutelis, A; Stasinopoulou, P, 2007)
"We recently experienced a case of acute pancreatitis caused by 5-ASA suppositories in a patient with ulcerative colitis."	1.34	[A case of acute pancreatitis caused by 5-aminosalicylic acid suppositories in a patient with ulcerative colitis]. ( Jang, BI; Kim, KH; Kim, TN, 2007)
"Symptomatic recurrence of diverticulitis occurred in 3 patients in group A, while 13 patients showed recurrence of diverticulitis in group B (p < 0."	1.31	Long-term treatment with mesalazine and rifaximin versus rifaximin alone for patients with recurrent attacks of acute diverticulitis of colon. ( Brandimarte, G; Daffinà, R; Tursi, A, 2002)
"Coloscopy demonstrated Crohn's disease of the colon, more marked on the left."	1.31	[Acute pancreatitis--adverse effect of 5-aminosalicylic acid (mesalazine) in various galenic dosage forms]. ( Ramadori, G; Schwörer, H, 2000)
"Severe acute inflammation in ulcerative colitis is often associated with major intestinal blood loss."	1.29	[Substitution of factor XIII concentrate in treatment refractory ulcerative colitis. A prospective pilot study]. ( Born, P; Classen, M; Lorenz, R, 1994)
"Prednisone treatment can sometimes reverse this condition when combined with parenteral nutrition."	1.27	[Acute manifestations in Crohn disease and ulcerative colitis. Conservative treatment of acute situations]. ( Goebell, H, 1988)

Research

Studies (115)

Authors

Clinical Trials (22)

Trial Overview

Trial Outcomes

Change in GSS From Baseline to Week 12 - ITT Population

Timeframe	Studies, this research(%)	All Research%
pre-1990	7 (6.09)	18.7374
1990's	26 (22.61)	18.2507
2000's	47 (40.87)	29.6817
2010's	31 (26.96)	24.3611
2020's	4 (3.48)	2.80

Authors	Studies
Lee, AA	1
Gupta, S	1
Labban, M	1
Cao, FT	1
Trinh, QD	1
McNabb-Baltar, J	1
Hegyi, PJ	1
Szakács, Z	1
Faluhelyi, N	1
Németh, BC	1
Bajor, J	1
Hegyi, P	3
Correia, JP	1
Ponte, AI	1
Silva, JC	1
Gomes, AC	1
Afecto, E	1
Smatlik, N	1
Mortada, N	1
Röcken, M	1
Yazdi, AS	1
Zierhut, M	1
Bartal, C	1
Sagy, I	1
Barski, L	1
Meczker, Á	2
Mikó, A	2
Picchio, M	2
Elisei, W	3
Tursi, A	7
Brandimarte, G	3
Gede, N	1
Szentesi, A	1
Párniczky, A	1
Gódi, S	1
Downton, TD	1
Willcocks, BJ	1
Boutlis, CS	1
Stollman, N	2
Magowan, S	1
Shanahan, F	1
Quigley, EM	1
Sang, LX	1
Chang, B	1
Dai, C	2
Gao, N	1
Liu, WX	1
Jiang, M	2
Russo, L	1
Schneider, G	1
Gardiner, MH	1
Lanes, S	1
Streck, P	1
Rosen, S	1
Ouakaa-Kchaou, A	1
Gargouri, D	1
Kochlef, A	1
Bibani, N	1
Elloumi, H	1
Trad, D	1
Kharrat, J	1
Jaung, R	1
Robertson, J	1
Vather, R	1
Rowbotham, D	1
Bissett, IP	1
Nespoli, L	1
Lo Bianco, G	1
Uggeri, F	1
Romano, F	1
Nespoli, A	1
Bernasconi, DP	1
Gianotti, L	1
Smalley, W	1
Hirano, I	1
Humes, D	2
Spiller, RC	2
Khan, MA	1
Ali, B	1
Lee, WM	1
Howden, CW	1
Sun, MJ	1
Fan, YC	1
Peery, AF	1
Dorofeyev, AE	1
Rassokhina, OA	1
Dorofeyeva, AA	1
Vidon, M	1
Perrod, G	1
Rahmi, G	1
Cellier, C	1
Bermejo, F	1
Lopez-Sanroman, A	1
Taxonera, C	1
Gisbert, JP	2
Pérez-Calle, JL	1
Vera, I	1
Menchén, L	1
Martín-Arranz, MD	1
Opio, V	1
Carneros, JA	1
Van-Domselaar, M	1
Mendoza, JL	1
Luna, M	1
López, P	1
Calvo, M	1
Algaba, A	1
Kamm, MA	2
Lichtenstein, GR	1
Sandborn, WJ	1
Schreiber, S	1
Lees, K	1
Barrett, K	1
Joseph, R	1
MacDermott, RP	1
Green, JA	1
Ashley, CC	1
Bresci, G	1
Parisi, G	1
Mazzoni, A	1
Scatena, F	1
Capria, A	1
Son, CN	1
Lee, HL	1
Joo, YW	1
Lee, OY	1
Han, DS	1
Yoon, BC	1
Choi, HS	1
Hahm, JS	1
Simpson, J	4
Cury, DB	1
Moss, AC	1
Pitchumoni, CS	1
Rubin, A	1
Das, K	1
Ng, SC	1
Plamondon, S	1
Hart, AL	1
Al-Hassi, HO	1
Guenther, T	1
Stagg, AJ	1
Knight, SC	1
Andrejic, J	1
Rojas-Balcazar, J	1
Dennis, M	1
Berkelhammer, C	1
Vinklerová, I	1
Procházka, M	1
Procházka, V	1
Urbánek, K	1
Shin, DH	1
Lee, KH	1
Kim, CH	1
Kim, KH	2
Park, SH	1
Chang, DK	1
Lee, JK	1
Lee, KT	1
Turner, D	1
Travis, SP	1
Griffiths, AM	1
Ruemmele, FM	1
Levine, A	1
Benchimol, EI	1
Dubinsky, M	1
Alex, G	1
Baldassano, RN	1
Langer, JC	1
Shamberger, R	1
Hyams, JS	1
Cucchiara, S	1
Bousvaros, A	1
Escher, JC	1
Markowitz, J	1
Wilson, DC	1
van Assche, G	1
Russell, RK	1
Strate, LL	1
Modi, R	1
Cohen, E	1
Spiegel, BM	1
Tuteja, AK	1
Fang, JC	1
Al-Suqi, M	1
Stoddard, GJ	1
Hale, DC	1
Daffinà, R	1
Schroeder, KW	2
Pruitt, R	1
Hanson, J	1
Safdi, M	1
Wruble, L	1
Hardi, R	1
Johanson, J	1
Koval, G	1
Riff, D	1
Winston, B	1
Cross, A	1
Doty, P	1
Johnson, LK	1
Herrlinger, K	1
Fellermann, K	1
Stange, EF	1
Schölmerich, J	2
Nagy, F	1
Beglinger, Ch	1
Jo, Y	1
Matsumoto, T	1
Yada, S	1
Fujisawa, K	1
Esaki, M	1
Onai, N	1
Matsushima, K	1
Iida, M	1
Vecchi, M	1
Saibeni, S	1
Devani, M	1
Rondonotti, E	1
De Franchis, R	1
Sanguineti, G	1
Franzone, P	1
Marcenaro, M	1
Foppiano, F	1
Vitale, V	1
Toubanakis, C	1
Batziou, E	1
Sipsas, N	1
Galanopoulos, G	1
Tzivras, M	1
Archimandritis, A	1
Regueiro, MD	1
Reissmann, A	1
Bischoff, SC	1
Fleig, W	1
Lucci, E	1
Lattuneddu, A	1
Valpiani, D	1
Ricci, E	1
Dubini, A	1
Garcea, D	1
Spiller, R	3
Tadic, M	1
Grgurevic, I	1
Scukanec-Spoljar, M	1
Bozic, B	1
Marusic, S	1
Horvatic, I	1
Galesic, K	1
Jahraus, CD	1
Bettenhausen, D	1
Malik, U	1
Sellitti, M	1
St Clair, WH	1
Sari, I	1
Birlik, M	1
Cavdar, C	1
Sarioglu, S	1
Akpinar, H	1
Onen, F	1
Akkoc, N	1
Rinas, U	1
Adamek, HE	1
Bergman, R	1
Parkes, M	1
Floch, MH	1
White, JA	1
Soto-Fernández, S	1
González-Carro, P	1
De Pedro-Esteban, A	1
Legaz-Huidobro, ML	1
Pérez-Roldán, F	1
Roncero García-Escribano, O	1
Valbuena-González, M	1
Ruiz-Carrillo, F	1
Tekin, F	1
Ozütemiz, O	1
Ilter, T	1
Cohen, HD	1
Das, KM	1
Buschhausen, L	1
Kruis, W	1
Aymaz, S	1
Weber, M	1
Krakamp, B	1
Giorgetti, GM	1
Aiello, F	1
Uslu, N	1
Demir, H	1
Saltik-Temizel, IN	1
Topaloğlu, R	1
Gürakan, F	1
Yüce, A	1
Stasinopoulou, P	1
Kaziani, A	1
Mantzaris, G	1
Roussos, A	1
Skoutelis, A	1
Lakatos, L	1
Lakatos, PL	1
Safdi, AV	1
Cohen, RD	1
Wang, X	1
Zhao, L	1
Han, T	1
Chen, S	1
Wang, J	1
Kim, TN	1
Jang, BI	1
Zimmerer, T	1
Böcker, U	1
Wenz, F	1
Singer, MV	1
Campieri, M	1
Lanfranchi, GA	1
Brignola, C	1
Bazzocchi, G	1
Minguzzi, MR	1
Calari, MT	1
Austin, CA	1
Cann, PA	1
Jones, TH	1
Holdsworth, CD	1
Lorenz, R	1
Born, P	1
Classen, M	1
Debongnie, JC	1
Dekoninck, X	1
Turunen, U	1
Järvinen, HJ	1
Radke, M	1
Bartolomaeus, G	1
Müller, M	1
Richter, I	1
Lee, FI	1
Jewell, DP	1
Mani, V	1
Keighley, MR	1
Kingston, RD	1
Record, CO	2
Grace, RH	1
Daniels, S	1
Patterson, J	1
Smith, K	1
Lucidarme, D	1
Marteau, P	2
Foucault, M	1
Vautrin, B	1
Filoche, B	1
Resbeut, M	1
Cowen, D	1
Richaud, P	1
Bourdin, S	1
Dubois, JB	1
Mere, P	1
N'Guyen, TD	1
Miner, PB	1
Fernández, J	1
Sala, M	1
Panés, J	1
Feu, F	1
Navarro, S	1
Terés, J	1
Hanauer, SB	2
Gross, V	1
Marí, B	1
Brullet, E	1
Campo, R	1
Bustamante, E	1
Bombardó, J	1
Masutani, M	1
Takahashi, K	1
Matsuda, T	1
Ohira, K	1
Nomura, A	1
Sadaoka, K	1
Douchin, A	1
Suzuki, J	1
Kawakami, Y	1
Cutrufo, C	1
Evangelista, S	1
Cirillo, R	1
Ciucci, A	1
Conte, B	1
Lopez, G	1
Manzini, S	1
Maggi, CA	1
Adachi, E	1
Okazaki, K	1
Matsushima, Y	1
Seno, H	1
Uchida, K	1
Nakase, H	1
Kawanami, C	1
Nakamura, T	1
Chiba, T	1
Gálvez, J	1
Garrido, M	1
Merlos, M	1
Torres, MI	1
Zarzuelo, A	1
Schwörer, H	1
Ramadori, G	1
Fleig, WE	1
Gomollón, F	1
Maté, J	1
Pajares, JM	1
Merino Rivas, JL	1
Arambarri Segura, M	1
Quereda Rodríguez-Navarro, C	1
Dronda Núñez, F	1
Goebell, H	2
Eigler, FW	1
Erdkamp, F	1
Houben, M	1
Ackerman, E	1
Breed, W	1
van Spreeuwel, J	1
Eckardt, VF	1
Kanzler, G	1
Rieder, H	1
Ewe, K	1
Tran, K	1
Froguel, E	1
Jian, R	1
Lemann, M	1
Modigliani, R	1
Cobden, I	1
al-Mardini, H	1
Zaitoun, A	1
Romero Castro, R	1
Jiménez Sáenz, M	1
Pellicer Bautista, FJ	1
Domínguez Palomo, S	1
Herrerías Gutiérrez, JM	1
Tromm, A	1
May, B	1
Mehta, RP	1
Fiorentini, MT	1
Fracchia, M	1
Galatola, G	1
Barlotta, A	1
de la Pierre, M	1
Sachedina, B	1
Saibil, F	1
Cohen, LB	1
Whittey, J	1
Grimaud, JC	1
Maillot, A	1
Bremondy, A	1
Thervet, L	1
Salducci, J	1
Cappello, M	1
Puleo, A	1
Calabrese, A	1
Cipolla, C	1
Orlando, A	1
Gatto, G	1
Oliva, L	1
Cottone, M	1
Tremaine, WJ	1
Ilstrup, DM	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
A Randomized, Double-blind, Placebo-controlled Study to Assess the Safety and Efficacy of a 12 Week Treatment of Acute Diverticulitis With Asacol® 2.4 g/Day (400 mg Mesalamine Tablet), Followed by a 9 Month Treatment-free Observation Period[NCT00554099]	Phase 2	117 participants (Actual)	Interventional	2007-11-30	Completed
Clinical Trial for the Determination of Advanced Colonic Neoplasia Prevalence and the Need for Colonoscopy in Complicated and Uncomplicated Acute Diverticulitis[NCT03557216]		313 participants (Actual)	Interventional	2018-06-15	Completed
Randomized Multicentric Controlled Clinical Trial of Parallel Groups to Evaluate the Non-therapeutic Inferiority of a Free Diet With a Progressive Diet, in the Treatment of Non-complicated Acute Diverticulitis[NCT03496090]		134 participants (Actual)	Interventional	2018-04-16	Completed
A Phase III, Randomized, Multi-center, Open-label, 12 to 14 Month Extension Study to Evaluate the Safety and Tolerability of SPD476 (Mesalazine) Given Once Daily vs. Twice Daily for the Maintenance of Ulcerative Colitis in Remission.[NCT00151944]	Phase 3	400 participants	Interventional	2003-11-26	Completed
"A Phase 1b/2 Study to Demonstrate the Safety and Efficacy of EXE-346 Live Biotherapeutic to Reduce High Bowel Movement Frequency in Subjects With an Ileal Pouch-Anal Anastomosis (PROF). The PROF Study."[NCT05938465]	Phase 1/Phase 2	50 participants (Anticipated)	Interventional	2023-10-11	Recruiting
Managing Pediatric Acute Severe Colitis According to the 2011 ECCO-ESPGHAN Guidelines: Efficacy of Infliximab as a Rescue Therapy[NCT02170714]		31 participants (Actual)	Observational	2010-05-31	Completed
[NCT02003807]		102 participants (Actual)	Observational	2013-07-31	Completed
Multicentre Controlled, Randomized Clinical Trial to Compare the Efficacy and Safety of Ambulatory Treatment of Mild Acute Diverticulitis Without Antibiotics With the Standard Treatment With Antibiotics[NCT02785549]	Phase 4	480 participants (Actual)	Interventional	2016-11-30	Completed
Hypnotherapy for Prevention of Relapse in Ulcerative Colitis: a Randomised, Single-blind, Controlled Clinical Trial[NCT00553163]		26 participants (Actual)	Interventional	2007-10-31	Terminated (stopped due to Unable to recruit sufficient numbers of patinets in the time available)
An Observational Study of the Immunopathogenesis of and Response to Step-Up Inflammatory Bowel Disease Therapy for Hermansky-Pudlak Syndrome-Associated Colitis[NCT00514982]	Phase 2	0 participants (Actual)	Interventional	2007-08-07	Withdrawn
A Cluster Randomized Controlled Trial of a Care-Path for the Management of Ulcerative Colitis[NCT01882426]	Phase 4	192 participants (Actual)	Interventional	2014-05-31	Terminated
Responsiveness of Endoscopic Evaluation of Ulcerative Colitis Using a Central Reader Based Image Management System[NCT01960439]		194 participants (Actual)	Observational	2013-07-31	Completed
Low Dose IL-2 for the Treatment of Crohn's Disease[NCT04263831]	Phase 1/Phase 2	30 participants (Anticipated)	Interventional	2021-03-11	Recruiting
A Phase I Study of Low Dose Subcutaneous Interleukin-2 (IL-2) For The Treatment of Ulcerative Colitis.[NCT02200445]	Phase 1	26 participants (Actual)	Interventional	2015-02-28	Completed
Phase 3: Randomised Controlled Trial of Rituximab in Active Ulcerative Colitis[NCT00261118]	Phase 2/Phase 3	24 participants (Actual)	Interventional	2004-04-30	Completed
A Randomized, Double-Blind, Comparative Trial of the Safety and Efficacy of Famotidine vs Placebo for the Treatment of Non-Hospitalized Symptomatic Adults With COVID-19[NCT04724720]	Phase 2	56 participants (Actual)	Interventional	2021-01-19	Active, not recruiting
Prevalance of non_ Alcoholic Fatty Liver Diseases in Patient With Inflammatory Bowel Diseases Attending Assiut University Hospitals[NCT04328259]		30 participants (Anticipated)	Observational	2020-10-01	Not yet recruiting
Investigation of the Faecal Loss of Vedolizumab and Its Role in Influencing Serum Drug Levels, Outcomes and Response in Ulcerative Colitis[NCT04006080]	Phase 4	30 participants (Anticipated)	Interventional	2019-07-01	Recruiting
Pharmacokinetics of Infliximab and Tumor Necrosis Factor Concentrations in Serum, Stool, and Colonic Mucosa in Acute Severe Ulcerative Colitis[NCT03765450]		18 participants (Actual)	Observational	2018-12-21	Active, not recruiting
New Insight and Knowledge on Anti-inflammatory Effectiveness of Dietary Phenolics (NIKE)[NCT03000101]		18 participants (Actual)	Interventional	2017-01-19	Active, not recruiting
Confocal Laser Endomicroscopy Findings in Patients With Proctosigmoiditis Before and After Initiation of Treatment[NCT01684514]		29 participants (Actual)	Interventional	2012-10-31	Completed
Pilot Study for the Evaluation of Food Choices and Exclusion of Gluten From the Diet in Patients With Inflammatory Bowel Diseases[NCT05079932]		45 participants (Anticipated)	Observational	2021-04-01	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

GSS - Abdominal Pain & Symptom Rating, scale 0-none (better) to 6-severe (worse) for each of the following categories: abdominal pain, abdominal tenderness, nausea/vomiting, bloating, constipation, diarrhea, mucus in stool, feeling urge to evacuate but no bowel movement, painful straining with bowel movement, pain/difficulty urinating. Total minimum score 0 (better), total maximum score 60 (worse). (NCT00554099)
Timeframe: Baseline to Week 12

Change in GSS From Baseline to Week 52 - ITT Population

Intervention	Scores on a Scale (Mean)
Placebo	-16.14
Mesalamine	-17.63
Mesalamine & Probiotic	-16.11

Global Symptom Score (GSS) at Week 12, Primary Efficacy Population

Intervention	Scores on a Scale (Mean)
Placebo	-16.82
Mesalamine	-17.30
Mesalamine & Probiotic	-16.00

Percentage of Responders at Week 12 - ITT Population

Intervention	Scores on a Scale (Mean)
Placebo	7.3
Mesalamine	4.4
Mesalamine & Probiotic	5.9

Responder - patient whose GSS scores for all symptoms were either 0 or 1 GSS - Abdominal Pain & Symptom Rating, scale 0-none (better) to 6-severe (worse) for each of the following categories: abdominal pain, abdominal tenderness, nausea/vomiting, bloating, constipation, diarrhea, mucus in stool, feeling urge to evacuate but no bowel movement, painful straining with bowel movement, pain/difficulty urinating. Total minimum score 0 (better), total maximum score 60 (worse). (NCT00554099)
Timeframe: 12 Weeks

Percentage of Responders at Week 52 - ITT Population

Intervention	Percentage of Participants (Number)
Placebo	41.4
Mesalamine	62.5
Mesalamine & Probiotic	48.1

Recurrent Diverticulitis, Percentage, ITT Population, Week 12

Intervention	Percentage of Participants (Number)
Placebo	50.0
Mesalamine	66.7
Mesalamine & Probiotic	29.2

At least one report of recurrent diverticulitis since the last visit (prior to the Week 12 visit). (NCT00554099)
Timeframe: 12 Weeks

Recurrent Diverticulitis, Percentage, ITT Population, Week 52

Intervention	Percentage of Participants (Number)
Placebo	20.0
Mesalamine	12.5
Mesalamine & Probiotic	11.8

At least one report of recurrent diverticulitis since the last visit (prior to the Week 52 visit). (NCT00554099)
Timeframe: 52 Weeks

Withdrawal Due to Surgery for Diverticulitis, Percentage, ITT Population, Week 12

Hospital Anxiety and Depression Score-Anxiety, (HADSA) at Week 13

Intervention	Percentage of Participants (Number)
Placebo	31.0
Mesalamine	28.1
Mesalamine & Probiotic	37.0

Intervention	Percentage of Participants (Number)
Placebo	2.4
Mesalamine	5.0
Mesalamine & Probiotic	0.0

Measure of anxiety, HADS Hospital anxiety and depression scale. HADS questionnaire consists of a 14 question validated questionnaire, developed to measure anxiety and depression in the hospital setting. Each item is answered by the patient on a four point (0-3) response category so the possible scores range from 0 (minimum) to 21 (maximum) for anxiety and 0 (minimum) to 21 (maximum) for depression. Higher scores indicate worse outcome, (NCT00553163)
Timeframe: 13 weeks

Hospital Anxiety and Depression Score-Depression (HADSD)

Intervention	score on a scale (Median)
UC Patients Given Gut-focussed Hpynotherapy	7
UC Patients Given Control Educational Sessions	10

Measure of depression. Each item is answered by the patient on a four point (0-3) response category so the possible scores range from 0 to 21 for anxiety and 0 to 21 for depression. Each item is answered by the patient on a four point (0-3) response category so the possible scores range from 0 (minimum) to 21 (maximum) for anxiety and (minimum) to 21 (maximum) for depression. Higher scores worse outcome. (NCT00553163)
Timeframe: 13 weeks

Inflammatory Bowel Disease Questionnaire (IBDQ) at Week 13

Intervention	units on a scale (Median)
UC Patients Given Gut-focussed Hypnotherapy	1.5
UC Patients Given Control Educational Sessions	4

IBDQ (standard measure of IBD patients' Quality of life (QoL) (Irvine et al 1982 approx). The IBDQ is a validated and reliable tool to measure of health-related quality of life in adult patients with IBD. The questionnaire consists of 32 questions scored in four domains: bowel symptoms, emotional health, systemic systems and social function. Scores range from 1 (poorest QoL) to 7 (best QoL). Higher scores indicate better QoL. Lowest score 7, highest score 224. (NCT00553163)
Timeframe: 13 weeks

Perceived Stress Questionnaire-Recent (PSQ-R)

Intervention	units on a scale (Median)
UC Patients Given Gut-focussed Hypnotherapy	195
UC Patients Given Control Educational Sessions	192

Measure of recent psychological stress. THE PSQ R consists of a 30 question questionnaires: recent, in which the statements used apply to the last month in which used statements apply to the last two years (Appendix 1.3). The score for both recent and general stress levels were stated as the PSQ index ranging from 0 (non-stressed) to 0.99 (highly stressed). Higher scores indicate worse outcome. (NCT00553163)
Timeframe: 13 weeks

Relapse at 1 Year

Intervention	units on a scale (Median)
UC Patients Given Gut-focussed Hypnotherapy	0.3
UC Patients Given Control Educational Sessions	0.4

The number of patients suffering a relapse was compared between the two treatment groups, and was the primary outcome parameter of this study. (NCT00553163)
Timeframe: 1 year

Number of Subjects With Serious and Non-serious Adverse Events.

Intervention	Participants (Count of Participants)
UC Patients Given Gut-focussed Hypnotherapy	8
UC Patients Given Control Educational Sessions	7

Enumeration of the serious and non-serious adverse events seen in the study. Enumeration of any dose limiting toxicity seen in the study. (NCT02200445)
Timeframe: 8 weeks

Intervention	Participants (Count of Participants)
Interleukin-2 Dose A	0
Interleukin-2 Dose B	0
Interleukin-2 Dose C	0

Article	Year
Drug-induced eosinophilic pneumonia: A review of 196 case reports. Medicine, 2018, Volume: 97, Issue:4 Topics: Acute Disease; Adult; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Chronic Diseas	2018
5-ASA induces mild acute pancreatitis. Case report and review of the literature. Journal of gastrointestinal and liver diseases : JGLD, 2018, Volume: 27, Issue:2 Topics: Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Mesalamine; Pancreati	2018
Mesalazine to treat symptomatic uncomplicated diverticular disease and to prevent acute diverticulitis occurrence. A systematic review with meta-analysis of randomized, placebo-controlled trials. Journal of gastrointestinal and liver diseases : JGLD, 2018, Volume: 27, Issue:3 Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Diverticulit	2018
Diverticulosis today. Minerva gastroenterologica e dietologica, 2019, Volume: 65, Issue:1 Topics: Acute Disease; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Dietary Fiber; Divert	2019
Changes in the approach to acute diverticulitis. ANZ journal of surgery, 2015, Volume: 85, Issue:10 Topics: Acute Disease; Anti-Bacterial Agents; Anti-Inflammatory Agents; Diverticulitis; Diverticulitis, Colo	2015
New medical strategies for the management of acute diverticulitis. Expert review of gastroenterology & hepatology, 2015, Volume: 9, Issue:10 Topics: Acute Disease; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Colonoscopy; Dietary	2015
Colonic diverticular disease: medical treatments for acute diverticulitis. BMJ clinical evidence, 2016, Feb-04, Volume: 2016 Topics: Acute Disease; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Diverticulitis; Human	2016
Mesalamine Does Not Help Prevent Recurrent Acute Colonic Diverticulitis: Meta-Analysis of Randomized, Placebo-Controlled Trials. The American journal of gastroenterology, 2016, Volume: 111, Issue:4 Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Diverticulitis, Colonic; Humans; Mesalamine;	2016
Mesalazine in preventing acute diverticulitis occurrence: a meta-analysis of randomized controlled trials. Journal of gastrointestinal and liver diseases : JGLD, 2016, Volume: 25, Issue:3 Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Chi-Square Distribution; Diverticulitis, Col	2016
Therapeutic management of acute uncomplicated diverticulitis. Minerva gastroenterologica e dietologica, 2017, Volume: 63, Issue:2 Topics: Acute Disease; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as To	2017
Colonic diverticular disease. BMJ clinical evidence, 2007, Aug-15, Volume: 2007 Topics: Acute Disease; Diverticulitis; Diverticulitis, Colonic; Diverticulosis, Colonic; Diverticulum; Human	2007
Pancreatitis in inflammatory bowel diseases. Journal of clinical gastroenterology, 2010, Volume: 44, Issue:4 Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Colitis, Ulcerative; Crohn Dis	2010
Consensus for managing acute severe ulcerative colitis in children: a systematic review and joint statement from ECCO, ESPGHAN, and the Porto IBD Working Group of ESPGHAN. The American journal of gastroenterology, 2011, Volume: 106, Issue:4 Topics: Acute Disease; Adrenal Cortex Hormones; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroid	2011
Diverticular disease as a chronic illness: evolving epidemiologic and clinical insights. The American journal of gastroenterology, 2012, Volume: 107, Issue:10 Topics: Abdominal Pain; Acute Disease; Age Distribution; Anti-Infective Agents; Anti-Inflammatory Agents, No	2012
Diverticular disease as a chronic illness: evolving epidemiologic and clinical insights. The American journal of gastroenterology, 2012, Volume: 107, Issue:10 Topics: Abdominal Pain; Acute Disease; Age Distribution; Anti-Infective Agents; Anti-Inflammatory Agents, No	2012
Diverticular disease as a chronic illness: evolving epidemiologic and clinical insights. The American journal of gastroenterology, 2012, Volume: 107, Issue:10 Topics: Abdominal Pain; Acute Disease; Age Distribution; Anti-Infective Agents; Anti-Inflammatory Agents, No	2012
Diverticular disease as a chronic illness: evolving epidemiologic and clinical insights. The American journal of gastroenterology, 2012, Volume: 107, Issue:10 Topics: Abdominal Pain; Acute Disease; Age Distribution; Anti-Infective Agents; Anti-Inflammatory Agents, No	2012
Role of mesalazine in acute and long-term treatment of ulcerative colitis and its complications. Scandinavian journal of gastroenterology. Supplement, 2002, Issue:236 Topics: Acute Disease; Administration, Oral; Administration, Rectal; Aminosalicylic Acids; Anti-Inflammatory	2002
[Standard therapy of ulcerative colitis. Evidence- and consensus-based recommendations]. Der Internist, 2002, Volume: 43, Issue:11 Topics: Acute Disease; Administration, Rectal; Adrenal Cortex Hormones; Colectomy; Colitis, Ulcerative; Croh	2002
[Conservative therapy of inflammatory bowel diseases]. Orvosi hetilap, 2002, Dec-15, Volume: 143, Issue:50 Topics: Acute Disease; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Chro	2002
[Treatment of Crohn's disease]. Therapeutische Umschau. Revue therapeutique, 2003, Volume: 60, Issue:3 Topics: Acute Disease; Adjuvants, Immunologic; Adrenal Cortex Hormones; Algorithms; Aminosalicylic Acids; An	2003
Review article: diagnosis, monitoring and treatment of distal colitis. Alimentary pharmacology & therapeutics, 2003, Volume: 17 Suppl 2 Topics: Acute Disease; Administration, Oral; Administration, Rectal; Anti-Inflammatory Agents, Non-Steroidal	2003
Acute diverticulitis of the colon--current medical therapeutic management. Expert opinion on pharmacotherapy, 2004, Volume: 5, Issue:1 Topics: Acute Disease; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Diverticulitis, Colon	2004
Diagnosis and treatment of ulcerative proctitis. Journal of clinical gastroenterology, 2004, Volume: 38, Issue:9 Topics: Acute Disease; Diagnosis, Differential; Diarrhea; Hemorrhage; Humans; Mesalamine; Proctocolitis; Rec	2004
Colonic diverticular disease. Clinical evidence, 2004, Issue:11 Topics: Acute Disease; Anti-Infective Agents; Dietary Fiber; Diverticulitis, Colonic; Diverticulum, Colon; H	2004
Colonic diverticular disease. Clinical evidence, 2004, Issue:12 Topics: Acute Disease; Anti-Infective Agents; Dietary Fiber; Diverticulitis, Colonic; Diverticulum, Colon; H	2004
[Diverticulosis/diverticulitis? What are conservative therapy possibilities?]. Medizinische Klinik (Munich, Germany : 1983), 2006, Jan-15, Volume: 101, Issue:1 Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-	2006
Systematic review: the use of mesalazine in inflammatory bowel disease. Alimentary pharmacology & therapeutics, 2006, Apr-01, Volume: 23, Issue:7 Topics: Acute Disease; Administration, Oral; Administration, Topical; Anti-Inflammatory Agents, Non-Steroida	2006
Systematic review: the use of mesalazine in inflammatory bowel disease. Alimentary pharmacology & therapeutics, 2006, Apr-01, Volume: 23, Issue:7 Topics: Acute Disease; Administration, Oral; Administration, Topical; Anti-Inflammatory Agents, Non-Steroida	2006
Systematic review: the use of mesalazine in inflammatory bowel disease. Alimentary pharmacology & therapeutics, 2006, Apr-01, Volume: 23, Issue:7 Topics: Acute Disease; Administration, Oral; Administration, Topical; Anti-Inflammatory Agents, Non-Steroida	2006
Systematic review: the use of mesalazine in inflammatory bowel disease. Alimentary pharmacology & therapeutics, 2006, Apr-01, Volume: 23, Issue:7 Topics: Acute Disease; Administration, Oral; Administration, Topical; Anti-Inflammatory Agents, Non-Steroida	2006
Colonic diverticular disease. Clinical evidence, 2005, Issue:14 Topics: Acute Disease; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Dietary Fiber; Divert	2005
Management of diverticular disease is changing. World journal of gastroenterology, 2006, May-28, Volume: 12, Issue:20 Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Diagnosis, Differential; Diverticulitis, Col	2006
The metabolism of mesalamine and its possible use in colonic diverticulitis as an anti-inflammatory agent. Journal of clinical gastroenterology, 2006, Volume: 40 Suppl 3 Topics: Acute Disease; Administration, Oral; Administration, Rectal; Anti-Inflammatory Agents, Non-Steroidal	2006
[Medical therapy of inflammatory bowel diseases: Crohn's disease]. Orvosi hetilap, 2007, Jun-17, Volume: 148, Issue:24 Topics: Acute Disease; Adrenal Cortex Hormones; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Ster	2007
Review article: increasing the dose of oral mesalazine therapy for active ulcerative colitis does not improve remission rates. Alimentary pharmacology & therapeutics, 2007, Nov-01, Volume: 26, Issue:9 Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Delayed-Action Preparat	2007
Medical prevention and treatment of acute and chronic radiation induced enteritis--is there any proven therapy? a short review. Zeitschrift fur Gastroenterologie, 2008, Volume: 46, Issue:5 Topics: Abdominal Neoplasms; Acute Disease; Chronic Disease; Combined Modality Therapy; Controlled Clinical	2008
[The treatment of ulcerative colitis]. Duodecim; laaketieteellinen aikakauskirja, 1993, Volume: 109, Issue:2 Topics: Acute Disease; Adrenal Cortex Hormones; Aminosalicylic Acids; Colitis, Ulcerative; Humans; Mesalamin	1993
[Treatment and recurrence prevention ulcerative colitis]. Der Internist, 1995, Volume: 36, Issue:12 Topics: Acute Disease; Adrenal Cortex Hormones; Aminosalicylic Acids; Anti-Inflammatory Agents, Non-Steroida	1995
Factors influencing the relapse of patients with inflammatory bowel disease. The American journal of gastroenterology, 1997, Volume: 92, Issue:12 Suppl Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Humans; Infections; Inflammatory Bowel Disea	1997
[5-Aminosalicylic acid-induced acute pancreatitis]. Gastroenterologia y hepatologia, 1999, Volume: 22, Issue:1 Topics: Acute Disease; Adult; Colitis, Ulcerative; Female; Humans; Mesalamine; Pancreatitis	1999
[Acute myocarditis due to mesalazine in a patient with ulcerative colitis]. Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 1999, Volume: 96, Issue:5 Topics: Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Humans; Male; Me	1999
Acute pancreatitis secondary to 5-aminosalicylic acid therapy in a patient with ulcerative colitis. International journal of pancreatology : official journal of the International Association of Pancreatology, 1999, Volume: 25, Issue:3 Topics: Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Drug Hypersensit	1999
[Guidelines of the DGVS. Acute process. German Society of Digestive and Metabolic Diseases]. Zeitschrift fur Gastroenterologie, 2001, Volume: 39, Issue:1 Topics: Acute Disease; Administration, Oral; Administration, Rectal; Anti-Inflammatory Agents; Anti-Inflamma	2001
Role of 5-aminosalicylic acid (5-ASA) in treatment of inflammatory bowel disease: a systematic review. Digestive diseases and sciences, 2002, Volume: 47, Issue:3 Topics: Acute Disease; Administration, Oral; Administration, Topical; Anti-Inflammatory Agents, Non-Steroida	2002
[Acute pleuropericarditis in a patient with Crohn's disease controlled with chronic therapy with mesalazine]. Revista clinica espanola, 2002, Volume: 202, Issue:2 Topics: Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Crohn Disease; Female; Humans; Mesala	2002
[Long-term therapy and timing of surgical intervention in ulcerative colitis and Crohn disease]. Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 1992, Volume: 63, Issue:1 Topics: Acute Disease; Aminosalicylic Acids; Colitis, Ulcerative; Combined Modality Therapy; Crohn Disease;	1992

Article	Year
A randomized controlled study of mesalamine after acute diverticulitis: results of the DIVA trial. Journal of clinical gastroenterology, 2013, Volume: 47, Issue:7 Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Bifidobacter	2013
Effect of extended MMX mesalamine therapy for acute, mild-to-moderate ulcerative colitis. Inflammatory bowel diseases, 2009, Volume: 15, Issue:1 Topics: Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Delayed-Action P	2009
Granulocytapheresis versus methylprednisolone in patients with acute ulcerative colitis: 12-month follow up. Journal of gastroenterology and hepatology, 2008, Volume: 23, Issue:11 Topics: Acute Disease; Administration, Oral; Adult; Anti-Inflammatory Agents; Colitis, Ulcerative; Colonosco	2008
Immunosuppressive effects via human intestinal dendritic cells of probiotic bacteria and steroids in the treatment of acute ulcerative colitis. Inflammatory bowel diseases, 2010, Volume: 16, Issue:8 Topics: Acute Disease; Adrenal Cortex Hormones; Adult; Aged; Azathioprine; B7-2 Antigen; CD40 Antigens; Coli	2010
Double-blind placebo-controlled study of mesalamine in post-infective irritable bowel syndrome--a pilot study. Scandinavian journal of gastroenterology, 2012, Volume: 47, Issue:10 Topics: Abdominal Pain; Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Diarrhea; Dou	2012
Balsalazide is superior to mesalamine in the time to improvement of signs and symptoms of acute mild-to-moderate ulcerative colitis. The American journal of gastroenterology, 2002, Volume: 97, Issue:12 Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Aminosalicylic Acids; Anti-Inflammatory A	2002
Sucralfate versus mesalazine versus hydrocortisone in the prevention of acute radiation proctitis during conformal radiotherapy for prostate carcinoma. A randomized study. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2003, Volume: 179, Issue:7 Topics: Acute Disease; Aged; Aged, 80 and over; Contraindications; Data Interpretation, Statistical; Dose Fr	2003
Prevention of acute radiation-induced proctosigmoiditis by balsalazide: a randomized, double-blind, placebo controlled trial in prostate cancer patients. International journal of radiation oncology, biology, physics, 2005, Dec-01, Volume: 63, Issue:5 Topics: Acute Disease; Aged; Aminosalicylic Acids; Anti-Ulcer Agents; Colon, Sigmoid; Double-Blind Method; H	2005
[Characterization of proteinuria in patients with ulcerative colitis and therapy with aminosalicylates]. Medizinische Klinik (Munich, Germany : 1983), 2006, Oct-15, Volume: 101, Issue:10 Topics: Acute Disease; Adolescent; Adult; Aminosalicylic Acids; Anti-Inflammatory Agents, Non-Steroidal; Col	2006
Balsalazide and/or high-potency probiotic mixture (VSL#3) in maintaining remission after attack of acute, uncomplicated diverticulitis of the colon. International journal of colorectal disease, 2007, Volume: 22, Issue:9 Topics: Acute Disease; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Bifidobacterium; Diverticulitis	2007
A randomised trial comparing mesalazine and prednisolone foam enemas in patients with acute distal ulcerative colitis. Gut, 1996, Volume: 38, Issue:2 Topics: Acute Disease; Administration, Rectal; Adolescent; Adult; Aged; Aged, 80 and over; Aminosalicylic Ac	1996
Efficacy and tolerance of mesalazine suppositories vs. hydrocortisone foam in proctitis. Alimentary pharmacology & therapeutics, 1997, Volume: 11, Issue:2 Topics: Acute Disease; Administration, Topical; Adult; Aminosalicylic Acids; Anti-Inflammatory Agents; Anti-	1997
A randomized double blind placebo controlled multicenter study of mesalazine for the prevention of acute radiation enteritis. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 1997, Volume: 44, Issue:1 Topics: Acute Disease; Adult; Aged; Aminosalicylic Acids; Anti-Inflammatory Agents, Non-Steroidal; Diarrhea;	1997
Dose-ranging study of mesalamine (PENTASA) enemas in the treatment of acute ulcerative proctosigmoiditis: results of a multicentered placebo-controlled trial. The U.S. PENTASA Enema Study Group. Inflammatory bowel diseases, 1998, Volume: 4, Issue:2 Topics: Acute Disease; Adult; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcera	1998
Balsalazide led to greater remission rates and tolerance than mesalamine in acute ulcerative colitis. Gut, 1999, Volume: 44, Issue:4 Topics: Acute Disease; Aminosalicylic Acids; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; F	1999
Is topical therapy necessary in acute distal colitis? Double-blind comparison of high-dose oral mesalazine versus steroid enemas in the treatment of active distal ulcerative colitis. Alimentary pharmacology & therapeutics, 1991, Volume: 5, Issue:5 Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Aged; Aminosalicylic Acids; Colitis, Ulcerat	1991
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. The New England journal of medicine, 1987, Dec-24, Volume: 317, Issue:26 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aminosalicylic Acids; Clinical Trials as Topic; Co	1987

Article	Year
Drug-induced acute pancreatitis due to medications used for inflammatory bowel disease: A VigiBase pharmacovigilance database study. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2023, Volume: 23, Issue:6 Topics: Acute Disease; Arthritis, Rheumatoid; Biological Products; Colitis, Ulcerative; Crohn Disease; Human	2023
Recurrent acute pancreatitis induced by 5-ASA and azathioprine in ulcerative colitis. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2020, Volume: 20, Issue:8 Topics: Acute Disease; Adult; Azathioprine; Colitis, Ulcerative; Humans; Male; Mesalamine; Pancreatitis; Rec	2020
Mesalazine-induced acute pancreatitis: a rare adverse reaction but with important therapeutic implications in ulcerative colitis. European journal of gastroenterology & hepatology, 2021, 04-01, Volume: 33, Issue:4 Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Humans; Mesalamine; Pan	2021
Mesalazine Suppresses Proinflammatory Cytokines in Patients with Acute Anterior Uveitis Independently of HLA-B27. Ocular immunology and inflammation, 2022, Volume: 30, Issue:6 Topics: Acute Disease; Cytokines; HLA-B27 Antigen; Humans; Mesalamine; Uveitis, Anterior	2022
Retrospective Matched-Cohort Analysis of Acute Pancreatitis Induced by 5-Aminosalicylic Acid-Derived Drugs. Pancreas, 2019, Volume: 48, Issue:4 Topics: Acute Disease; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Child; Female; Humans; Ma	2019
Acute myopericarditis in a patient recently started on mesalazine for Crohn disease. Internal medicine journal, 2019, Volume: 49, Issue:5 Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Crohn Disease; Humans; Male; Mesalamine; Mid	2019
Heat-killed VSL#3 ameliorates dextran sulfate sodium (DSS)-induced acute experimental colitis in rats. International journal of molecular sciences, 2013, Dec-19, Volume: 15, Issue:1 Topics: Acute Disease; Animals; Colitis; Dextran Sulfate; Disease Models, Animal; Hot Temperature; Interleuk	2013
Role of pharmacoepidemiology studies in addressing pharmacovigilance questions: a case example of pancreatitis risk among ulcerative colitis patients using mesalazine. European journal of clinical pharmacology, 2014, Volume: 70, Issue:6 Topics: Acute Disease; Adverse Drug Reaction Reporting Systems; Anti-Inflammatory Agents, Non-Steroidal; Col	2014
Acute pancreatitis secondary to long-term 5- aminosalicylic acid therapy in a patient with ulcerative colitis: a case-report. La Tunisie medicale, 2014, Volume: 92, Issue:6 Topics: Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Humans; Male; Me	2014
[The first oral budesonide: effective in an acute episode]. MMW Fortschritte der Medizin, 2015, Jul-23, Volume: 157, Issue:13 Topics: Acute Disease; Administration, Oral; Administration, Rectal; Budesonide; Colitis, Ulcerative; Drug A	2015
Effect of oral mesalamine on inflammatory response in acute uncomplicated diverticulitis. World journal of gastroenterology, 2015, Jul-21, Volume: 21, Issue:27 Topics: Acute Disease; Administration, Oral; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Bioma	2015
American Gastroenterological Association Institute Guideline on the Management of Acute Diverticulitis. Gastroenterology, 2015, Volume: 149, Issue:7 Topics: Acute Disease; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Colectomy; Colonoscop	2015
American Gastroenterological Association Institute Guideline on the Management of Acute Diverticulitis. Gastroenterology, 2015, Volume: 149, Issue:7 Topics: Acute Disease; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Colectomy; Colonoscop	2015
American Gastroenterological Association Institute Guideline on the Management of Acute Diverticulitis. Gastroenterology, 2015, Volume: 149, Issue:7 Topics: Acute Disease; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Colectomy; Colonoscop	2015
American Gastroenterological Association Institute Guideline on the Management of Acute Diverticulitis. Gastroenterology, 2015, Volume: 149, Issue:7 Topics: Acute Disease; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Colectomy; Colonoscop	2015
Mesalamine in Recurrent Acute Colonic Diverticulitis. The American journal of gastroenterology, 2016, Volume: 111, Issue:11 Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Diverticulitis; Diverticulitis, Colonic; Hum	2016
Late-Onset of Acute Severe Ulcerative Colitis: Clinical Case. Digestive diseases (Basel, Switzerland), 2017, Volume: 35, Issue:1-2 Topics: Acute Disease; Age of Onset; Azathioprine; Colitis, Ulcerative; Humans; Infliximab; Intestinal Mucos	2017
Acute dysphagia in a patient with Crohn disease. Clinics and research in hepatology and gastroenterology, 2017, Volume: 41, Issue:4 Topics: Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Crohn Disease; Deglutition Disorders;	2017
Acute pancreatitis in inflammatory bowel disease, with special reference to azathioprine-induced pancreatitis. Alimentary pharmacology & therapeutics, 2008, Sep-01, Volume: 28, Issue:5 Topics: Acute Disease; Adult; Antimetabolites; Azathioprine; Cohort Studies; Female; Humans; Inflammatory Bo	2008
What is the optimal therapy for severe ulcerative colitis? Inflammatory bowel diseases, 2008, Volume: 14 Suppl 2 Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Colectomy; Colitis,	2008
[A case of acute pancreatitis induced by multiple drugs in a patient with ulcerative colitis]. The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 2008, Volume: 52, Issue:3 Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites; Azathioprine; Colitis, Ulce	2008
Ocular manifestations in a community-based cohort of patients with inflammatory bowel disease. Inflammatory bowel diseases, 2010, Volume: 16, Issue:8 Topics: Acute Disease; Adalimumab; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; A	2010
Azathioprine-induced hypersensitivity hepatitis: tolerance to 6-mercaptopurine. Inflammatory bowel diseases, 2010, Volume: 16, Issue:11 Topics: Acute Disease; Azathioprine; Chemical and Drug Induced Liver Injury; Colitis, Ulcerative; Drug Hyper	2010
Incidence, severity, and etiology of drug-induced acute pancreatitis. Digestive diseases and sciences, 2010, Volume: 55, Issue:10 Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Azathioprine; Child; Child, Preschool; Cr	2010
[A case of inferior vena cava thrombosis and acute pancreatitis in a patient with ulcerative colitis]. The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 2010, Volume: 56, Issue:4 Topics: Acute Disease; Amylases; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Cholangiopancreato	2010
Long-term treatment with mesalazine and rifaximin versus rifaximin alone for patients with recurrent attacks of acute diverticulitis of colon. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2002, Volume: 34, Issue:7 Topics: Acute Disease; Aged; Anti-Inflammatory Agents, Non-Steroidal; Diverticulitis, Colonic; Drug Therapy,	2002
[Acute episode]. Zeitschrift fur Gastroenterologie, 2003, Volume: 41, Issue:1 Topics: Acute Disease; Adult; Age Factors; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal	2003
CCR4 is an up-regulated chemokine receptor of peripheral blood memory CD4+ T cells in Crohn's disease. Clinical and experimental immunology, 2003, Volume: 132, Issue:2 Topics: Acute Disease; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; CD4	2003
Acute pancreatitis after long-term therapy with mesalazine, and hyperamylasaemia associated with azathioprine in a patient with ulcerative colitis. European journal of gastroenterology & hepatology, 2003, Volume: 15, Issue:8 Topics: Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Colitis, Ulcerative; Hu	2003
[Ulcerative colitis. Acute episode]. Zeitschrift fur Gastroenterologie, 2004, Volume: 42, Issue:9 Topics: Acute Disease; Administration, Oral; Adrenal Cortex Hormones; Aminosalicylic Acids; Anti-Inflammator	2004
Skip lesion of the cecum associated with proctitis: an atypical case of ulcerative colitis. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2004, Volume: 36, Issue:12 Topics: Acute Disease; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Cecum; Colectomy; Colitis, Ulcer	2004
Acute interstitial nephritis due to mesalazine. Nephrology (Carlton, Vic.), 2005, Volume: 10, Issue:2 Topics: Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Humans; Male; Me	2005
Mesalazine-associated acute tubulointerstitial nephritis in a patient with spondylarthropathy. The New Zealand medical journal, 2005, Sep-16, Volume: 118, Issue:1222 Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Creatinine; Humans; Inflammatory Bowel Disea	2005
[Infliximab-induced hepatitis in a patient with Crohn's disease]. Gastroenterologia y hepatologia, 2006, Volume: 29, Issue:5 Topics: Acute Disease; Adult; Antibodies, Monoclonal; Azathioprine; Chemical and Drug Induced Liver Injury;	2006
Acute tubulointerstitial nephritis due to 5-aminosalicylic acid in a patient with ulcerative colitis and chronic renal failure. The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2006, Volume: 17, Issue:2 Topics: Acute Disease; Anti-Inflammatory Agents; Colitis, Ulcerative; Creatinine; Humans; Kidney Failure, Ch	2006
Acute tubular injury associated with mesalazine therapy in an adolescent girl with inflammatory bowel disease. Digestive diseases and sciences, 2007, Volume: 52, Issue:11 Topics: Acute Disease; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Diagnosis,	2007
Parallel manifestation of Crohn's disease and acute pericarditis: a report of two cases. International journal of colorectal disease, 2007, Volume: 22, Issue:9 Topics: Acute Disease; Adult; Crohn Disease; Female; Humans; Inflammatory Bowel Diseases; Male; Mesalamine;	2007
Protective effects of 2,3,5,4'-tetrahydroxystilbene-2-O-beta-d-glucoside, an active component of Polygonum multiflorum Thunb, on experimental colitis in mice. European journal of pharmacology, 2008, Jan-14, Volume: 578, Issue:2-3 Topics: Acetic Acid; Acute Disease; Animals; Anti-Inflammatory Agents; Antioxidants; Chronic Disease; Coliti	2008
[A case of acute pancreatitis caused by 5-aminosalicylic acid suppositories in a patient with ulcerative colitis]. The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 2007, Volume: 50, Issue:6 Topics: Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Humans; Male; Me	2007
5-aminosalicylic acid as rectal enema in ulcerative colitis patients unable to take sulphasalazine. Lancet (London, England), 1984, Feb-18, Volume: 1, Issue:8373 Topics: Acute Disease; Adult; Aged; Aminosalicylic Acids; Colitis, Ulcerative; Enema; Female; Humans; Male;	1984
Exacerbation of diarrhoea and pain in patients treated with 5-aminosalicylic acid for ulcerative colitis. Lancet (London, England), 1984, Apr-21, Volume: 1, Issue:8382 Topics: Acute Disease; Adolescent; Adult; Aminosalicylic Acids; Colitis, Ulcerative; Diarrhea; Female; Human	1984
[Substitution of factor XIII concentrate in treatment refractory ulcerative colitis. A prospective pilot study]. Medizinische Klinik (Munich, Germany : 1983), 1994, Oct-15, Volume: 89, Issue:10 Topics: Acute Disease; Aminosalicylic Acids; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; C	1994
Sulfasalazine, 5-ASA and acute pancreatitis in crohn's disease. Journal of clinical gastroenterology, 1994, Volume: 19, Issue:4 Topics: Acute Disease; Adult; Aminosalicylic Acids; Anti-Inflammatory Agents, Non-Steroidal; Crohn Disease;	1994
Acute pancreatitis in Crohn's disease due to 5-ASA therapy. Journal of pediatric gastroenterology and nutrition, 1993, Volume: 16, Issue:3 Topics: Acute Disease; Aminosalicylic Acids; Child; Crohn Disease; Humans; Male; Mesalamine; Pancreatitis; U	1993
Acute pancreatitis after long-term 5-aminosalicylic acid therapy. The American journal of gastroenterology, 1997, Volume: 92, Issue:12 Topics: Acute Disease; Adult; Amylases; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Female	1997
Efficacy of different mesalamine-releasing drugs. Gastroenterology, 1998, Volume: 115, Issue:5 Topics: Acute Disease; Aminosalicylic Acids; Anti-Ulcer Agents; Clinical Trials as Topic; Colitis, Ulcerativ	1998
Effect of MEN 11467, a new tachykinin NK1 receptor antagonist, in acute rectocolitis induced by acetic acid in guinea-pigs. European journal of pharmacology, 1999, Jun-18, Volume: 374, Issue:2 Topics: Acetic Acid; Acute Disease; Administration, Rectal; Animals; Anti-Inflammatory Agents, Non-Steroidal	1999
Intestinal anti-inflammatory activity of UR-12746, a novel 5-ASA conjugate, on acute and chronic experimental colitis in the rat. British journal of pharmacology, 2000, Volume: 130, Issue:8 Topics: Acute Disease; Aminosalicylic Acids; Animals; Anti-Inflammatory Agents; Aza Compounds; Chronic Disea	2000
[Acute pancreatitis--adverse effect of 5-aminosalicylic acid (mesalazine) in various galenic dosage forms]. Deutsche medizinische Wochenschrift (1946), 2000, Nov-03, Volume: 125, Issue:44 Topics: Acute Disease; Administration, Oral; Administration, Rectal; Adult; Anti-Inflammatory Agents, Non-St	2000
Pancreatitis induced by mesalamine. The Netherlands journal of medicine, 1992, Volume: 41, Issue:1-2 Topics: Acute Disease; Adult; Aminosalicylic Acids; Female; Humans; Inflammatory Bowel Diseases; Mesalamine;	1992
[Pancreatitis associated with 5-aminosalicylic acid]. Deutsche medizinische Wochenschrift (1946), 1991, Apr-05, Volume: 116, Issue:14 Topics: Acute Disease; Adult; Aminosalicylic Acids; Amylases; Clinical Enzyme Tests; Colitis, Ulcerative; Cr	1991
Acute pancreatitis induced by mesalazine. Journal of clinical gastroenterology, 1991, Volume: 13, Issue:6 Topics: Acute Disease; Administration, Oral; Adolescent; Aminosalicylic Acids; Enema; Humans; Male; Mesalami	1991
[Acute pancreatitis due to 5-aminosalicylic acid]. Revista espanola de enfermedades digestivas, 1991, Volume: 79, Issue:3 Topics: Acute Disease; Adult; Aminosalicylic Acids; Crohn Disease; Drug Therapy, Combination; Female; Humans	1991
[5-aminosalicylic acid-associated pancreatitis]. Deutsche medizinische Wochenschrift (1946), 1991, Jul-12, Volume: 116, Issue:28-29 Topics: Acute Disease; Aminosalicylic Acids; Humans; Inflammatory Bowel Diseases; Mesalamine; Pancreatitis	1991
Acute interstitial nephritis due to 5-aminosalicylic acid. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 1990, Nov-15, Volume: 143, Issue:10 Topics: Acute Disease; Adult; Aminosalicylic Acids; Colitis, Ulcerative; Humans; Male; Mesalamine; Nephritis	1990
Acute pancreatitis during oral 5-aminosalicylic acid therapy. Digestive diseases and sciences, 1990, Volume: 35, Issue:9 Topics: Acute Disease; Adult; Aminosalicylic Acids; Colitis, Ulcerative; Crohn Disease; Humans; Male; Mesala	1990
Acute pancreatitis due to 5-aminosalicylate. Annals of internal medicine, 1989, Mar-15, Volume: 110, Issue:6 Topics: Abdomen; Acute Disease; Adult; Aminosalicylic Acids; Amylases; Crohn Disease; Female; Humans; Mesala	1989
[Must sulfapyridine always be accused? Apropos of a case of acute pancreatitis caused by mesalazine]. Gastroenterologie clinique et biologique, 1989, Volume: 13, Issue:4 Topics: Acute Disease; Adult; Aminosalicylic Acids; Female; Humans; Mesalamine; Pancreatitis	1989
[5-aminosalicylic acid treatment of ulcerative colitis during the acute phase in patients resistant or intolerant to salazopyrine]. Recenti progressi in medicina, 1987, Volume: 78, Issue:2 Topics: Acute Disease; Adult; Aged; Aminosalicylic Acids; Colitis, Ulcerative; Drug Combinations; Drug Erupt	1987
[Acute manifestations in Crohn disease and ulcerative colitis. Conservative treatment of acute situations]. Langenbecks Archiv fur Chirurgie, 1988, Volume: Suppl 2 Topics: Acute Disease; Aminosalicylic Acids; Colitis, Ulcerative; Combined Modality Therapy; Crohn Disease;	1988

mesalamine and Acute Disease