Page last updated: 2024-10-30

mesalamine and Abdominal Pain

mesalamine has been researched along with Abdominal Pain in 30 studies

Mesalamine: An anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the active moiety of SULPHASALAZINE. (From Martindale, The Extra Pharmacopoeia, 30th ed)
mesalamine : A monohydroxybenzoic acid that is salicylic acid substituted by an amino group at the 5-position.

Abdominal Pain: Sensation of discomfort, distress, or agony in the abdominal region.

Research Excerpts

ExcerptRelevanceReference
"Patients who received mesalamine plus the mixture of beta-glucan, inositol and digestive enzymes (group A) reported a reduction in abdominal pain together with reduction in bloating and flatulence after four weeks of treatment."9.24Beta-glucan, inositol and digestive enzymes improve quality of life of patients with inflammatory bowel disease and irritable bowel syndrome. ( Cosco, C; Cosco, V; Doldo, P; Garieri, P; Mancina, RM; Ruggiero, G; Spagnuolo, R, 2017)
"Twenty patients who developed diarrhea-predominant IBS after gastroenteritis were randomized to receive mesalamine (AsacolĀ®) 1."9.16Double-blind placebo-controlled study of mesalamine in post-infective irritable bowel syndrome--a pilot study. ( Al-Suqi, M; Fang, JC; Hale, DC; Stoddard, GJ; Tuteja, AK, 2012)
"Mesalamine suppositories have been used widely for the treatment of distal ulcerative colitis and considered to be safer than systemic administration for its limited systemic absorption."5.40Ulcerative colitis flair induced by mesalamine suppositories hypersensitivity. ( Ding, H; Hu, J; Hu, XY; Liu, XC; Mei, Q; Xu, JM, 2014)
"Patients who received mesalamine plus the mixture of beta-glucan, inositol and digestive enzymes (group A) reported a reduction in abdominal pain together with reduction in bloating and flatulence after four weeks of treatment."5.24Beta-glucan, inositol and digestive enzymes improve quality of life of patients with inflammatory bowel disease and irritable bowel syndrome. ( Cosco, C; Cosco, V; Doldo, P; Garieri, P; Mancina, RM; Ruggiero, G; Spagnuolo, R, 2017)
"Twenty patients who developed diarrhea-predominant IBS after gastroenteritis were randomized to receive mesalamine (AsacolĀ®) 1."5.16Double-blind placebo-controlled study of mesalamine in post-infective irritable bowel syndrome--a pilot study. ( Al-Suqi, M; Fang, JC; Hale, DC; Stoddard, GJ; Tuteja, AK, 2012)
"Although oral mesalamine is the first-choice drug for treating mild-to-moderate ulcerative colitis (UC), some patients show symptoms of intolerance, including exacerbation of diarrhea and abdominal pain."4.02Multicenter survey on mesalamine intolerance in patients with ulcerative colitis. ( Fujiwara, A; Higashi, R; Hiraoka, S; Inokuchi, T; Kato, J; Matsueda, K; Miyaike, J; Moritou, Y; Okada, H; Suzuki, S; Takagi, S; Takahara, M; Toyokawa, T, 2021)
"5-ASA is used as first-line therapy for ulcerative colitis."3.01Significance of 5-Aminosalicylic Acid Intolerance in the Clinical Management of Ulcerative Colitis. ( Kanai, T; Kiyohara, H; Mikami, Y; Mizushima, I; Suzuki, S; Tsunoda, J, 2023)
"Mesalamine is a first-line drug in the treatment of inflammatory bowel diseases, while its intolerance occasionally occurs in clinical practice."2.61The culprit of mesalamine intolerance: case series and literature review. ( Fu, Y; Hong, F; Quan, R; Xie, C; Yan, W; Zou, K, 2019)
"Segmental colitis associated with colonic diverticulosis is a new and emerging entity."2.48Segmental colitis associated with diverticulosis: systematic evaluation of 486 cases with meta-analysis. ( Hoda, KK; Mann, NS, 2012)
"Eosinophilic colitis is a rare mostly self-limiting disease affecting middle-aged adults."1.40Eosinophilic colitis is a sporadic self-limited disease of middle-aged people: a population-based study. ( Alfadda, AA; Shaffer, EA; Storr, MA; Urbanski, SJ, 2014)
"Mesalamine suppositories have been used widely for the treatment of distal ulcerative colitis and considered to be safer than systemic administration for its limited systemic absorption."1.40Ulcerative colitis flair induced by mesalamine suppositories hypersensitivity. ( Ding, H; Hu, J; Hu, XY; Liu, XC; Mei, Q; Xu, JM, 2014)
"Diversion colitis is thought to result from nutritional deficiencies secondary to fecal diversion."1.30Diversion colitis: a cause of abdominal discomfort in spinal cord injury patients with colostomy. ( Chuang, TY; Francisco, GE; Lai, JM; Strayer, JR, 1997)
"Treatment with hydroxyurea was effective in lowering the thrombocyte count."1.30[Clinical decision making in family practice. A patient with abdominal pain and chills]. ( de Meijer, PH; Meinders, AE; Schippers, EF, 1998)

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (13.33)18.2507
2000's6 (20.00)29.6817
2010's17 (56.67)24.3611
2020's3 (10.00)2.80

Authors

AuthorsStudies
Mikami, Y1
Tsunoda, J1
Suzuki, S2
Mizushima, I1
Kiyohara, H1
Kanai, T1
Hiraoka, S1
Fujiwara, A1
Toyokawa, T1
Higashi, R1
Moritou, Y1
Takagi, S1
Matsueda, K1
Miyaike, J1
Inokuchi, T1
Takahara, M1
Kato, J1
Okada, H1
Senthamizh, T1
Senthamizhselvan, K1
Sahoo, NK1
Kaliaperumal, S1
Spagnuolo, R1
Cosco, C1
Mancina, RM1
Ruggiero, G1
Garieri, P1
Cosco, V1
Doldo, P1
Alamo, RZ1
Quigley, EMM1
Soga, K1
Itani, K1
Xie, C1
Quan, R1
Hong, F1
Zou, K1
Yan, W1
Fu, Y1
Kruis, W1
Meier, E1
Schumacher, M1
Mickisch, O1
Greinwald, R1
Mueller, R1
Mann, NS1
Hoda, KK1
Tursi, A3
Brandimarte, G2
Elisei, W2
Picchio, M2
Forti, G1
Pianese, G1
Rodino, S1
D'Amico, T1
Sacca, N1
Portincasa, P1
Capezzuto, E1
Lattanzio, R1
Spadaccini, A1
Fiorella, S1
Polimeni, F1
Polimeni, N1
Stoppino, V1
Stoppino, G1
Giorgetti, GM1
Aiello, F1
Danese, S1
Alfadda, AA1
Shaffer, EA1
Urbanski, SJ1
Storr, MA1
Snipelisky, DF1
Cable, CA1
Maniaci, MJ1
Ding, H1
Liu, XC1
Mei, Q1
Xu, JM1
Hu, XY1
Hu, J1
Schorr, M1
Vaidya, A1
Schulte, S1
Todd, DJ1
Conant, A1
Di Mario, F1
Scarpignato, C1
Lawlor, G1
Ahmed, A1
Moss, AC1
Strate, LL1
Modi, R1
Cohen, E1
Spiegel, BM1
Tuteja, AK1
Fang, JC1
Al-Suqi, M1
Stoddard, GJ1
Hale, DC1
Leighton, MP1
Lam, C1
Mehta, S1
Spiller, RC1
Hartwich, SA1
Ikeda, M1
Najima, M1
Morizane, C1
Ueno, H1
Okusaka, T1
Freeman, HJ1
Lai, JM1
Chuang, TY1
Francisco, GE1
Strayer, JR1
Oren, R1
Moshkowitz, M1
Odes, S1
Becker, S1
Keter, D1
Pomeranz, I1
Shirin, H1
Shirin, C1
Reisfeld, I1
Broide, E1
Lavy, A1
Fich, A1
Eliakim, R1
Patz, J1
Villa, Y1
Arber, N1
Gilat, T1
Schippers, EF1
de Meijer, PH1
Meinders, AE1
Abdo, AA1
Zetler, PJ1
Halparin, LS1
Iofel, E1
Chawla, A1
Daum, F1
Markowitz, J1
Butt, JH1

Clinical Trials (6)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Double-blind, Randomised, Placebo-controlled, Parallel-group, Multi-centre Phase III Clinical Study on the Efficacy and Tolerability of Mesalazine Pellets vs. Placebo in Diverticular Disease[NCT01627262]Phase 2123 participants (Actual)Interventional2002-05-31Completed
Mesalazine and/or Lactobacillus Casei in Maintaining Remission of Symptomatic Uncomplicated Diverticular Disease of the Colon: a Double-blind, Double-dummy, Placebo-controlled Study[NCT01534754]Phase 4250 participants (Actual)Interventional2009-01-31Completed
[NCT02003807]102 participants (Actual)Observational2013-07-31Completed
Multicentre Controlled, Randomized Clinical Trial to Compare the Efficacy and Safety of Ambulatory Treatment of Mild Acute Diverticulitis Without Antibiotics With the Standard Treatment With Antibiotics[NCT02785549]Phase 4480 participants (Actual)Interventional2016-11-30Completed
Prevalence of Segmental Colitis Associated With Colic Diverticulosis (SCAD): an Observational Study[NCT04279821]50 participants (Anticipated)Observational2020-02-01Recruiting
Risk-stratified Randomized Controlled Trial in Paediatric Crohn Disease:Methotrexate vs Azathioprine or Adalimumab for Maintaining Remission in Patients at Low or High Risk for Aggressive Disease Course, respectively-a Treatment Strategy[NCT02852694]Phase 4312 participants (Anticipated)Interventional2017-02-28Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

8 reviews available for mesalamine and Abdominal Pain

ArticleYear
Significance of 5-Aminosalicylic Acid Intolerance in the Clinical Management of Ulcerative Colitis.
    Digestion, 2023, Volume: 104, Issue:1

    Topics: Abdominal Pain; Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative;

2023
Irritable bowel syndrome and colonic diverticular disease: overlapping symptoms and overlapping therapeutic approaches.
    Current opinion in gastroenterology, 2019, Volume: 35, Issue:1

    Topics: Abdominal Pain; Anti-Inflammatory Agents, Non-Steroidal; Diagnosis, Differential; Diverticulosis, Co

2019
The culprit of mesalamine intolerance: case series and literature review.
    BMC gastroenterology, 2019, Jul-31, Volume: 19, Issue:1

    Topics: Abdominal Pain; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Diarrhea; Drug Eruptio

2019
Segmental colitis associated with diverticulosis: systematic evaluation of 486 cases with meta-analysis.
    Hepato-gastroenterology, 2012, Volume: 59, Issue:119

    Topics: Abdominal Pain; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Biopsy; Colitis; Colonosco

2012
37-year-old man with abdominal pain.
    Mayo Clinic proceedings, 2014, Volume: 89, Issue:4

    Topics: Abdominal Pain; Adult; Colitis, Ulcerative; Colonoscopy; Emergency Service, Hospital; Follow-Up Stud

2014
Diverticular disease as a chronic illness: evolving epidemiologic and clinical insights.
    The American journal of gastroenterology, 2012, Volume: 107, Issue:10

    Topics: Abdominal Pain; Acute Disease; Age Distribution; Anti-Infective Agents; Anti-Inflammatory Agents, No

2012
Diverticular disease as a chronic illness: evolving epidemiologic and clinical insights.
    The American journal of gastroenterology, 2012, Volume: 107, Issue:10

    Topics: Abdominal Pain; Acute Disease; Age Distribution; Anti-Infective Agents; Anti-Inflammatory Agents, No

2012
Diverticular disease as a chronic illness: evolving epidemiologic and clinical insights.
    The American journal of gastroenterology, 2012, Volume: 107, Issue:10

    Topics: Abdominal Pain; Acute Disease; Age Distribution; Anti-Infective Agents; Anti-Inflammatory Agents, No

2012
Diverticular disease as a chronic illness: evolving epidemiologic and clinical insights.
    The American journal of gastroenterology, 2012, Volume: 107, Issue:10

    Topics: Abdominal Pain; Acute Disease; Age Distribution; Anti-Infective Agents; Anti-Inflammatory Agents, No

2012
[Palliative therapy in patients with biliary tract cancer].
    Nihon rinsho. Japanese journal of clinical medicine, 2006, Volume: 64 Suppl 1

    Topics: Abdominal Pain; Analgesics; Antineoplastic Agents; Back Pain; Biliary Tract Neoplasms; Drainage; Fee

2006
Outpatient management of inflammatory bowel disease. Let's keep it as simple as possible.
    Postgraduate medicine, 1992, Nov-01, Volume: 92, Issue:6

    Topics: Abdominal Pain; Adrenal Cortex Hormones; Ambulatory Care; Aminosalicylic Acids; Anus Diseases; Diarr

1992

Trials

6 trials available for mesalamine and Abdominal Pain

ArticleYear
Beta-glucan, inositol and digestive enzymes improve quality of life of patients with inflammatory bowel disease and irritable bowel syndrome.
    European review for medical and pharmacological sciences, 2017, Volume: 21, Issue:2 Suppl

    Topics: Abdominal Pain; Anti-Inflammatory Agents, Non-Steroidal; beta-Glucans; Biological Factors; Drug Comb

2017
Randomised clinical trial: mesalazine (Salofalk granules) for uncomplicated diverticular disease of the colon--a placebo-controlled study.
    Alimentary pharmacology & therapeutics, 2013, Volume: 37, Issue:7

    Topics: Abdominal Pain; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Diverticulosis, Co

2013
Randomised clinical trial: mesalazine and/or probiotics in maintaining remission of symptomatic uncomplicated diverticular disease--a double-blind, randomised, placebo-controlled study.
    Alimentary pharmacology & therapeutics, 2013, Volume: 38, Issue:7

    Topics: Abdominal Pain; Aged; Anti-Inflammatory Agents, Non-Steroidal; Diverticulum, Colon; Double-Blind Met

2013
Double-blind placebo-controlled study of mesalamine in post-infective irritable bowel syndrome--a pilot study.
    Scandinavian journal of gastroenterology, 2012, Volume: 47, Issue:10

    Topics: Abdominal Pain; Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Diarrhea; Dou

2012
Efficacy and mode of action of mesalazine in the treatment of diarrhoea-predominant irritable bowel syndrome (IBS-D): study protocol for a randomised controlled trial.
    Trials, 2013, Jan-09, Volume: 14

    Topics: Abdominal Pain; Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Clinical Protocols; Defecation; Dia

2013
Methotrexate in chronic active Crohn's disease: a double-blind, randomized, Israeli multicenter trial.
    The American journal of gastroenterology, 1997, Volume: 92, Issue:12

    Topics: Abdominal Pain; Administration, Oral; Adolescent; Adrenal Cortex Hormones; Adult; Aged; Anti-Inflamm

1997

Other Studies

16 other studies available for mesalamine and Abdominal Pain

ArticleYear
Multicenter survey on mesalamine intolerance in patients with ulcerative colitis.
    Journal of gastroenterology and hepatology, 2021, Volume: 36, Issue:1

    Topics: Abdominal Pain; Administration, Oral; Adult; Colitis, Ulcerative; Diarrhea; Disease Progression; Fem

2021
Panuveitis in a patient with active Crohn's disease.
    BMJ case reports, 2021, Feb-04, Volume: 14, Issue:2

    Topics: Abdominal Pain; Adolescent; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Budes

2021
Hyposensitization trial using salazosulfapyridine in a case of mesalamine intolerance.
    Clinical journal of gastroenterology, 2019, Volume: 12, Issue:6

    Topics: Abdominal Pain; Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative;

2019
Eosinophilic colitis is a sporadic self-limited disease of middle-aged people: a population-based study.
    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, 2014, Volume: 16, Issue:2

    Topics: Abdominal Pain; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Cohort Studies; Colitis; Colon

2014
Ulcerative colitis flair induced by mesalamine suppositories hypersensitivity.
    World journal of gastroenterology, 2014, Apr-07, Volume: 20, Issue:13

    Topics: Abdominal Pain; Adult; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Colonoscopy; Di

2014
Interactive medical case. A man with diarrhea and back pain.
    The New England journal of medicine, 2015, Apr-09, Volume: 372, Issue:15

    Topics: Abdominal Pain; Adult; Anti-Inflammatory Agents; Back Pain; Colitis, Ulcerative; Colon; Colonoscopy;

2015
Prognostic Role of the Endoscopic Classification "DICA".
    Journal of clinical gastroenterology, 2016, Volume: 50 Suppl 1

    Topics: Abdominal Pain; Aged; Anti-Inflammatory Agents, Non-Steroidal; C-Reactive Protein; Colon; Colonoscop

2016
Once-daily mesalamine granules for ulcerative colitis.
    Expert review of clinical immunology, 2010, Volume: 6, Issue:4

    Topics: Abdominal Pain; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Colitis, Ulcerati

2010
Pill impaction mimicking appendicitis in ulcerative colitis.
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2012, Volume: 44, Issue:10

    Topics: Abdominal Pain; Appendicitis; Colitis, Ulcerative; Diagnosis, Differential; Endoscopy, Gastrointesti

2012
You're the flight surgeon. Crohn's disease.
    Aviation, space, and environmental medicine, 2004, Volume: 75, Issue:8

    Topics: Abdominal Pain; Adult; Aerospace Medicine; Anti-Inflammatory Agents, Non-Steroidal; Crohn Disease; D

2004
Natural history and long-term clinical behavior of segmental colitis associated with diverticulosis (SCAD syndrome).
    Digestive diseases and sciences, 2008, Volume: 53, Issue:9

    Topics: Abdominal Pain; Adult; Age Distribution; Aged; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Dia

2008
Diversion colitis: a cause of abdominal discomfort in spinal cord injury patients with colostomy.
    Archives of physical medicine and rehabilitation, 1997, Volume: 78, Issue:6

    Topics: Abdominal Pain; Aminosalicylic Acids; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colostomy; H

1997
[Clinical decision making in family practice. A patient with abdominal pain and chills].
    Nederlands tijdschrift voor geneeskunde, 1998, Jun-27, Volume: 142, Issue:26

    Topics: Abdominal Pain; Aged; Aged, 80 and over; Crohn Disease; Diagnosis, Differential; Drug Therapy, Combi

1998
Familial microscopic colitis.
    Canadian journal of gastroenterology = Journal canadien de gastroenterologie, 2001, Volume: 15, Issue:5

    Topics: Abdominal Pain; Adult; Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Colitis; Colonoscopy; Consti

2001
Oral balsalazide (Colazal) for ulcerative colitis.
    The Medical letter on drugs and therapeutics, 2001, Jul-23, Volume: 43, Issue:1109

    Topics: Abdominal Pain; Administration, Oral; Aminosalicylic Acids; Anti-Ulcer Agents; Colitis, Ulcerative;

2001
Mesalamine intolerance mimics symptoms of active inflammatory bowel disease.
    Journal of pediatric gastroenterology and nutrition, 2002, Volume: 34, Issue:1

    Topics: Abdominal Pain; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Diarrhea; Female; Humans; Infla

2002