meropenem and Lymphohistiocytosis--Hemophagocytic

Hemophagocytic lymphohistiocytosis (HLH) is a rare condition with high mortality. We report a case of a 74-year-old woman with rheumatoid arthritis who developed HLH secondary to pyelonephritis due to Escherichia coli infection following infliximab treatment. Bone marrow aspiration showed proliferation of histiocytes with hemophagocytosis. The patient died despite treatment with intravenous antibiotics intravenous methylprednisolone and intravenous immunoglobulin. Cytokine levels were measured and are discussed.

Topics: Aged; Anti-Bacterial Agents; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Bone Marrow; Escherichia coli Infections; Fatal Outcome; Female; Histiocytes; Humans; Immunocompromised Host; Immunoglobulins, Intravenous; Immunosuppressive Agents; Infliximab; Lymphohistiocytosis, Hemophagocytic; Meropenem; Methylprednisolone; Pyelonephritis; Thienamycins

In contrast to enteric fever, reports of secondary hemophagocytic lymphohistiocytosis (HLH) in invasive non-typhoidal salmonellosis are scarce. We report a child with ceftriaxone-resistant invasive

Topics: Anti-Bacterial Agents; Ceftriaxone; Child; Drug Resistance, Bacterial; Humans; Lymphohistiocytosis, Hemophagocytic; Male; Meropenem; Salmonella enteritidis; Salmonella Infections; Typhoid Fever

Topics: Adult; Anti-Bacterial Agents; Anti-Inflammatory Agents; Brain Abscess; Combined Modality Therapy; Craniotomy; Dexamethasone; Drug Monitoring; Drug Therapy, Combination; Etoposide; Humans; Infusions, Intravenous; Lymphohistiocytosis, Hemophagocytic; Magnetic Resonance Imaging; Male; Meropenem; Neuroimaging; Neutrophil Infiltration; Topoisomerase II Inhibitors; Treatment Outcome

Topics: Anti-Bacterial Agents; Bone Marrow; Burkholderia pseudomallei; Ceftazidime; Humans; Liver Abscess; Lymphohistiocytosis, Hemophagocytic; Male; Melioidosis; Meropenem; Middle Aged; Thienamycins; Tomography, X-Ray Computed

To describe a case of hemophagocytic lymphohistiocytosis (HLH) with ocular changes prior to the systemic changes.. A 53-year-old man presented with the chief complaint of decreased vision in his right eye. The patient was examined by ocular examination, slit lamp examination, optical coherence tomography, laboratory examination, abdominal ultrasound, and bone marrow biopsy.. Ocular examination revealed uveitis OD and optical coherence tomography revealed macular edema OD. Laboratory examination demonstrated cytopenia in two cell lines, hypofibrinogenemia, and elevated serum ferritin. Abdominal ultrasound findings indicated hepatosplenomegaly. The bone marrow biopsy specimen demonstrated histiocytes and significant hemophagocytosis, leading to a diagnosis of HLH.. Ophthalmic manifestation can be the first sign of HLH and progress to fatal systemic changes.

Topics: Anti-Bacterial Agents; Biopsy; Bone Marrow; Drug Therapy, Combination; Fatal Outcome; Hepatomegaly; Humans; Immunoglobulins, Intravenous; Lymphohistiocytosis, Hemophagocytic; Macular Edema; Male; Meropenem; Methylprednisolone; Middle Aged; Panuveitis; Slit Lamp Microscopy; Splenomegaly; Thienamycins; Tomography, Optical Coherence